Result of FASTA (omim) for pF1KE4276
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE4276, 1261 aa
  1>>>pF1KE4276     1261 - 1261 aa - 1261 aa
Library: /omim/omim.rfq.tfa
  64092750 residues in 91774 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.6989+/-0.000471; mu= 1.7475+/- 0.029
 mean_var=274.2762+/-57.871, 0's: 0 Z-trim(116.6): 227  B-trim: 36 in 1/54
 Lambda= 0.077443
 statistics sampled from 28587 (28851) to 28587 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.314), width:  16
 Scan time:  8.000

The best scores are:                                      opt bits E(91774)
NP_001315593 (OMIM: 610496) rho GTPase-activating  (1261) 8250 936.9       0
XP_011540741 (OMIM: 610496) rho GTPase-activating  (1261) 8250 936.9       0
NP_004806 (OMIM: 610496) rho GTPase-activating pro (1261) 8250 936.9       0
NP_001315594 (OMIM: 610496) rho GTPase-activating  (1197) 7821 889.0       0
NP_001315596 (OMIM: 610496) rho GTPase-activating  (1197) 7821 889.0       0
NP_001315595 (OMIM: 610496) rho GTPase-activating  (1252) 5552 635.5 7.3e-181
XP_016882351 (OMIM: 609694) GEM-interacting protei ( 835) 1170 145.7 1.3e-33
XP_011526350 (OMIM: 609694) GEM-interacting protei ( 849) 1170 145.7 1.3e-33
XP_016882350 (OMIM: 609694) GEM-interacting protei ( 884) 1170 145.8 1.4e-33
NP_057657 (OMIM: 609694) GEM-interacting protein i ( 970) 1170 145.8 1.4e-33
NP_001269263 (OMIM: 601155) rho GTPase-activating  ( 771) 1059 133.3 6.6e-30
XP_024307203 (OMIM: 601155) rho GTPase-activating  ( 821) 1054 132.8   1e-29
XP_005259984 (OMIM: 609694) GEM-interacting protei ( 967) 1048 132.2 1.8e-29
NP_036424 (OMIM: 601155) rho GTPase-activating pro (1136) 1024 129.5 1.3e-28
NP_001308161 (OMIM: 601155) rho GTPase-activating  (1140) 1024 129.5 1.3e-28
NP_001245257 (OMIM: 601155) rho GTPase-activating  (1152) 1024 129.5 1.3e-28
NP_001269264 (OMIM: 601155) rho GTPase-activating  (1019)  986 125.3 2.3e-27
XP_006722776 (OMIM: 601155) rho GTPase-activating  (1164)  975 124.1   6e-27
XP_011526160 (OMIM: 601155) rho GTPase-activating  (1168)  975 124.1   6e-27
NP_001275927 (OMIM: 609694) GEM-interacting protei ( 941)  675 90.5 6.3e-17
NP_001275928 (OMIM: 609694) GEM-interacting protei ( 944)  671 90.0 8.6e-17
XP_011519925 (OMIM: 604875,618198) unconventional  (1737)  276 46.1  0.0026
XP_016877719 (OMIM: 604875,618198) unconventional  (2547)  276 46.3  0.0035
NP_008832 (OMIM: 604875,618198) unconventional myo (2548)  276 46.3  0.0035
XP_016877718 (OMIM: 604875,618198) unconventional  (2566)  276 46.3  0.0035
XP_011519924 (OMIM: 604875,618198) unconventional  (2566)  276 46.3  0.0035
XP_011519923 (OMIM: 604875,618198) unconventional  (2598)  276 46.3  0.0036
XP_011519922 (OMIM: 604875,618198) unconventional  (2618)  276 46.3  0.0036
XP_011519921 (OMIM: 604875,618198) unconventional  (2619)  276 46.3  0.0036
XP_006720602 (OMIM: 604875,618198) unconventional  (2619)  276 46.3  0.0036
XP_011519920 (OMIM: 604875,618198) unconventional  (2620)  276 46.3  0.0036
XP_011519919 (OMIM: 604875,618198) unconventional  (2637)  276 46.3  0.0036
XP_011519918 (OMIM: 604875,618198) unconventional  (2638)  276 46.3  0.0036
XP_011519915 (OMIM: 604875,618198) unconventional  (2638)  276 46.3  0.0036
XP_011519917 (OMIM: 604875,618198) unconventional  (2638)  276 46.3  0.0036
XP_011519916 (OMIM: 604875,618198) unconventional  (2638)  276 46.3  0.0036
NP_001306780 (OMIM: 610576) rho GTPase-activating  ( 420)  250 42.7  0.0068
NP_001354352 (OMIM: 610576) rho GTPase-activating  ( 516)  250 42.8  0.0079
XP_005269142 (OMIM: 610576) rho GTPase-activating  ( 535)  250 42.8  0.0081
XP_005269141 (OMIM: 610576) rho GTPase-activating  ( 535)  250 42.8  0.0081
NP_001073625 (OMIM: 610576) rho GTPase-activating  ( 547)  250 42.8  0.0083
NP_001354355 (OMIM: 610576) rho GTPase-activating  ( 547)  250 42.8  0.0083
NP_001306781 (OMIM: 610576) rho GTPase-activating  ( 566)  250 42.8  0.0085
XP_016875289 (OMIM: 610576) rho GTPase-activating  ( 566)  250 42.8  0.0085
XP_005269140 (OMIM: 610576) rho GTPase-activating  ( 566)  250 42.8  0.0085
XP_016880032 (OMIM: 600365) active breakpoint clus ( 660)  250 42.9  0.0095
XP_016880031 (OMIM: 600365) active breakpoint clus ( 663)  250 42.9  0.0095
XP_011536960 (OMIM: 610576) rho GTPase-activating  ( 700)  250 42.9  0.0099


>>NP_001315593 (OMIM: 610496) rho GTPase-activating prot  (1261 aa)
 initn: 8250 init1: 8250 opt: 8250  Z-score: 4997.7  bits: 936.9 E(91774):    0
Smith-Waterman score: 8250; 100.0% identity (100.0% similar) in 1261 aa overlap (1-1261:1-1261)

               10        20        30        40        50        60
pF1KE4 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE4 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE4 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE4 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE4 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE4 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE4 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE4 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE4 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE4 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE4 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE4 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE4 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE4 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE4 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE4 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
             1210      1220      1230      1240      1250      1260

        
pF1KE4 V
       :
NP_001 V
        

>>XP_011540741 (OMIM: 610496) rho GTPase-activating prot  (1261 aa)
 initn: 8250 init1: 8250 opt: 8250  Z-score: 4997.7  bits: 936.9 E(91774):    0
Smith-Waterman score: 8250; 100.0% identity (100.0% similar) in 1261 aa overlap (1-1261:1-1261)

               10        20        30        40        50        60
pF1KE4 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE4 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE4 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE4 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE4 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE4 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE4 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE4 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE4 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE4 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE4 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE4 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE4 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE4 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE4 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE4 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
             1210      1220      1230      1240      1250      1260

        
pF1KE4 V
       :
XP_011 V
        

>>NP_004806 (OMIM: 610496) rho GTPase-activating protein  (1261 aa)
 initn: 8250 init1: 8250 opt: 8250  Z-score: 4997.7  bits: 936.9 E(91774):    0
Smith-Waterman score: 8250; 100.0% identity (100.0% similar) in 1261 aa overlap (1-1261:1-1261)

               10        20        30        40        50        60
pF1KE4 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE4 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE4 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE4 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE4 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE4 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE4 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE4 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE4 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE4 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE4 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE4 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE4 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE4 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE4 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE4 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
             1210      1220      1230      1240      1250      1260

        
pF1KE4 V
       :
NP_004 V
        

>>NP_001315594 (OMIM: 610496) rho GTPase-activating prot  (1197 aa)
 initn: 7821 init1: 7821 opt: 7821  Z-score: 4738.9  bits: 889.0 E(91774):    0
Smith-Waterman score: 7821; 100.0% identity (100.0% similar) in 1193 aa overlap (69-1261:5-1197)

       40        50        60        70        80        90        
pF1KE4 IFDPDYIKELVNDIRKFSHMLLYLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNS
                                     ::::::::::::::::::::::::::::::
NP_001                           MERRDCFKEVIHIRLEELLRVLKSIMNKHQNLNS
                                         10        20        30    

      100       110       120       130       140       150        
pF1KE4 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
           40        50        60        70        80        90    

      160       170       180       190       200       210        
pF1KE4 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKY
          100       110       120       130       140       150    

      220       230       240       250       260       270        
pF1KE4 TKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQ
          160       170       180       190       200       210    

      280       290       300       310       320       330        
pF1KE4 QTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDE
          220       230       240       250       260       270    

      340       350       360       370       380       390        
pF1KE4 YEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEE
          280       290       300       310       320       330    

      400       410       420       430       440       450        
pF1KE4 RRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYD
          340       350       360       370       380       390    

      460       470       480       490       500       510        
pF1KE4 PGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRC
          400       410       420       430       440       450    

      520       530       540       550       560       570        
pF1KE4 SNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSS
          460       470       480       490       500       510    

      580       590       600       610       620       630        
pF1KE4 ADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVEC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVEC
          520       530       540       550       560       570    

      640       650       660       670       680       690        
pF1KE4 EECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENR
          580       590       600       610       620       630    

      700       710       720       730       740       750        
pF1KE4 ALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFR
          640       650       660       670       680       690    

      760       770       780       790       800       810        
pF1KE4 LYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSL
          700       710       720       730       740       750    

      820       830       840       850       860       870        
pF1KE4 HFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFL
          760       770       780       790       800       810    

      880       890       900       910       920       930        
pF1KE4 ITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSE
          820       830       840       850       860       870    

      940       950       960       970       980       990        
pF1KE4 SESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLK
          880       890       900       910       920       930    

     1000      1010      1020      1030      1040      1050        
pF1KE4 SDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNR
          940       950       960       970       980       990    

     1060      1070      1080      1090      1100      1110        
pF1KE4 KDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHS
         1000      1010      1020      1030      1040      1050    

     1120      1130      1140      1150      1160      1170        
pF1KE4 INATQPSKPYAEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INATQPSKPYAEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRG
         1060      1070      1080      1090      1100      1110    

     1180      1190      1200      1210      1220      1230        
pF1KE4 NEEKPASPSAAVPPGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEEKPASPSAAVPPGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPM
         1120      1130      1140      1150      1160      1170    

     1240      1250      1260 
pF1KE4 CQRPRLKRMQQFEDLEGEIPQFV
       :::::::::::::::::::::::
NP_001 CQRPRLKRMQQFEDLEGEIPQFV
         1180      1190       

>>NP_001315596 (OMIM: 610496) rho GTPase-activating prot  (1197 aa)
 initn: 7821 init1: 7821 opt: 7821  Z-score: 4738.9  bits: 889.0 E(91774):    0
Smith-Waterman score: 7821; 100.0% identity (100.0% similar) in 1193 aa overlap (69-1261:5-1197)

       40        50        60        70        80        90        
pF1KE4 IFDPDYIKELVNDIRKFSHMLLYLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNS
                                     ::::::::::::::::::::::::::::::
NP_001                           MERRDCFKEVIHIRLEELLRVLKSIMNKHQNLNS
                                         10        20        30    

      100       110       120       130       140       150        
pF1KE4 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
           40        50        60        70        80        90    

      160       170       180       190       200       210        
pF1KE4 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKY
          100       110       120       130       140       150    

      220       230       240       250       260       270        
pF1KE4 TKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQ
          160       170       180       190       200       210    

      280       290       300       310       320       330        
pF1KE4 QTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDE
          220       230       240       250       260       270    

      340       350       360       370       380       390        
pF1KE4 YEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEE
          280       290       300       310       320       330    

      400       410       420       430       440       450        
pF1KE4 RRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYD
          340       350       360       370       380       390    

      460       470       480       490       500       510        
pF1KE4 PGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRC
          400       410       420       430       440       450    

      520       530       540       550       560       570        
pF1KE4 SNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSS
          460       470       480       490       500       510    

      580       590       600       610       620       630        
pF1KE4 ADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVEC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVEC
          520       530       540       550       560       570    

      640       650       660       670       680       690        
pF1KE4 EECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENR
          580       590       600       610       620       630    

      700       710       720       730       740       750        
pF1KE4 ALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFR
          640       650       660       670       680       690    

      760       770       780       790       800       810        
pF1KE4 LYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSL
          700       710       720       730       740       750    

      820       830       840       850       860       870        
pF1KE4 HFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFL
          760       770       780       790       800       810    

      880       890       900       910       920       930        
pF1KE4 ITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSE
          820       830       840       850       860       870    

      940       950       960       970       980       990        
pF1KE4 SESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLK
          880       890       900       910       920       930    

     1000      1010      1020      1030      1040      1050        
pF1KE4 SDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNR
          940       950       960       970       980       990    

     1060      1070      1080      1090      1100      1110        
pF1KE4 KDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHS
         1000      1010      1020      1030      1040      1050    

     1120      1130      1140      1150      1160      1170        
pF1KE4 INATQPSKPYAEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INATQPSKPYAEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRG
         1060      1070      1080      1090      1100      1110    

     1180      1190      1200      1210      1220      1230        
pF1KE4 NEEKPASPSAAVPPGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEEKPASPSAAVPPGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPM
         1120      1130      1140      1150      1160      1170    

     1240      1250      1260 
pF1KE4 CQRPRLKRMQQFEDLEGEIPQFV
       :::::::::::::::::::::::
NP_001 CQRPRLKRMQQFEDLEGEIPQFV
         1180      1190       

>>NP_001315595 (OMIM: 610496) rho GTPase-activating prot  (1252 aa)
 initn: 8177 init1: 5524 opt: 5552  Z-score: 3368.6  bits: 635.5 E(91774): 7.3e-181
Smith-Waterman score: 8163; 99.3% identity (99.3% similar) in 1261 aa overlap (1-1261:1-1252)

               10        20        30        40        50        60
pF1KE4 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE4 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE4 CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
       :::::::         ::::::::::::::::::::::::::::::::::::::::::::
NP_001 CDLTLKA---------HLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
                       430       440       450       460       470 

              490       500       510       520       530       540
pF1KE4 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
             480       490       500       510       520       530 

              550       560       570       580       590       600
pF1KE4 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
             540       550       560       570       580       590 

              610       620       630       640       650       660
pF1KE4 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
             600       610       620       630       640       650 

              670       680       690       700       710       720
pF1KE4 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
             660       670       680       690       700       710 

              730       740       750       760       770       780
pF1KE4 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
             720       730       740       750       760       770 

              790       800       810       820       830       840
pF1KE4 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
             780       790       800       810       820       830 

              850       860       870       880       890       900
pF1KE4 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
             840       850       860       870       880       890 

              910       920       930       940       950       960
pF1KE4 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
             900       910       920       930       940       950 

              970       980       990      1000      1010      1020
pF1KE4 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
             960       970       980       990      1000      1010 

             1030      1040      1050      1060      1070      1080
pF1KE4 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
            1020      1030      1040      1050      1060      1070 

             1090      1100      1110      1120      1130      1140
pF1KE4 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
            1080      1090      1100      1110      1120      1130 

             1150      1160      1170      1180      1190      1200
pF1KE4 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
            1140      1150      1160      1170      1180      1190 

             1210      1220      1230      1240      1250      1260
pF1KE4 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
            1200      1210      1220      1230      1240      1250 

        
pF1KE4 V
       :
NP_001 V
        

>>XP_016882351 (OMIM: 609694) GEM-interacting protein is  (835 aa)
 initn: 1596 init1: 527 opt: 1170  Z-score: 725.0  bits: 145.7 E(91774): 1.3e-33
Smith-Waterman score: 1664; 38.8% identity (67.7% similar) in 778 aa overlap (129-893:18-764)

      100       110       120       130       140       150        
pF1KE4 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
                                     ....: :...: ...::.  ..: ::    
XP_016              MDAAEPGLPPGPEGRKRYSDIFRSLDNLEISLGNVTLEMLAGD---P
                            10        20        30        40       

      160       170       180       190          200       210     
pF1KE4 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPL---ELDNVLLKNTDSIELALSYAKTW
        : . :   .: .   ..  :  :.    .  ::   :::  :...  ... :: :::::
XP_016 LLSEDPEPDKTPTATVTNEASCWSGPSPEGPVPLTGEELDLRLIRTKGGVDAALEYAKTW
           50        60        70        80        90       100    

         220       230       240       250       260       270     
pF1KE4 SKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSH
       :.:.:....:.::. . ::: ... .:.::: ...:  :  :::: ..:  : .:.  . 
XP_016 SRYAKELLAWTEKRASYELEFAKSTMKIAEAGKVSIQQQSHMPLQYIYTLFLEHDLSLGT
          110       120       130       140       150       160    

         280       290       300       310       320       330     
pF1KE4 LLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQR
       : ..:.:  :   . ::: ....:.:: :::.:: : .::..: :: .::..:.:  .::
XP_016 LAMETVAQ-QKRDYYQPLAAKRTEIEKWRKEFKEQWMKEQKRMNEAVQALRRAQLQYVQR
          170        180       190       200       210       220   

         340       350       360       370       380       390     
pF1KE4 QDEYEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTN
       ...  .:.:.    .    .: :      .:: :..:: .:::  :..::. ::..:: .
XP_016 SEDL-RARSQGSPEDSAPQASPGP-----SKQQERRRRSREEAQAKAQEAEALYQACVRE
            230       240            250       260       270       

         400       410       420       430       440       450     
pF1KE4 VEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAK
       .. :..::: .:..:....: :::: : .:. ::..:: ..  ::     .. .: .   
XP_016 ANARQQDLEIAKQRIVSHVRKLVFQGDEVLRRVTLSLFGLRGAQAERGPRAFAALAECCA
       280       290       300       310       320       330       

         460       470       480         490       500       510   
pF1KE4 LYDPGQEYSEFVKATNSTEEEKVDG--NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKI
        ..:::.:.:::.:             . .. : : . : .   ..:     ::    ..
XP_016 PFEPGQRYQEFVRALRPEAPPPPPPAFSFQEFLPSLNSSPLDIRKKLSGP--LPP---RL
       340       350       360       370       380         390     

           520       530           540       550       560         
pF1KE4 EEDRCSNSADITGPSFIRSW--TFGMF--SDSESTGGSSESRSLDSESISPGDFHRKLPR
       .:.  .. .    :.    :  : :    :: .:.::.:::::::: . :::   :.: .
XP_016 DENS-AEPGPWEDPGTGWRWQGTPGPTPGSDVDSVGGGSESRSLDSPTSSPGAGTRQLVK
             400       410       420       430       440       450 

     570       580       590       600        610       620        
pF1KE4 TPSSGTMSSADDLDEREPPSPSETGPNSLGT-FKKTLMSKAALTHKFRKLRSPTKCRDCE
       . :.:: :: ::..::.: . ..   :.::. : :  .:.:: ::..:.::.:.:::.::
XP_016 ASSTGTESS-DDFEERDP-DLGDGLENGLGSPFGKWTLSSAAQTHQLRRLRGPAKCRECE
             460         470       480       490       500         

      630       640       650       660       670       680        
pF1KE4 GIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFIL
       ...: .:.:::::.:.::..:::.:.:.:::..::..  :::..: :. .  :. .::..
XP_016 AFMV-SGTECEECFLTCHKRCLETLLILCGHRRLPARTPLFGVDFLQLPRDFPEEVPFVV
     510        520       530       540       550       560        

      690       700       710       720       730       740        
pF1KE4 KICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLR
         :..:::.::: .:::::: :.....:.::::.:::  ::..:  : ::. .::: .:.
XP_016 TKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVELSGNSPHDVSSVLKRFLQ
      570       580       590       600       610       620        

      750       760       770       780       790       800        
pF1KE4 QLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLR
       .: :: : :.::  ::.::: . :..          .:   :.   :. : :   : :: 
XP_016 ELTEPVIPFHLYDAFISLAKTL-HADPG--------DDPGTPSPSPEVIRSL---KTLLV
      630       640       650                660       670         

      810       820       830       840       850          860     
pF1KE4 QLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPR--PTTAP-ITISSL
       ::: ::.:.:. :..:: ::. .  ::::...:::..:::.:.::   : .:  : .. :
XP_016 QLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCL
        680       690       700       710       720       730      

         870       880       890       900       910       920     
pF1KE4 AEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKS
        . ..::.::::::.. ..::  .  ::                                
XP_016 LDSGHQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPAPGPLTTSSQPPPPHLDPDSQ
        740       750       760       770       780       790      

>>XP_011526350 (OMIM: 609694) GEM-interacting protein is  (849 aa)
 initn: 1377 init1: 527 opt: 1170  Z-score: 724.9  bits: 145.7 E(91774): 1.3e-33
Smith-Waterman score: 1461; 37.0% identity (63.3% similar) in 792 aa overlap (257-1029:25-770)

        230       240       250       260       270       280      
pF1KE4 EKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQA
                                     :::: ..:  : .:.  . : ..:.:  : 
XP_011       MPRPGAAMPRNCLPGLKREPAMSHMPLQYIYTLFLEHDLSLGTLAMETVAQ-QK
                     10        20        30        40        50    

        290       300       310       320       330       340      
pF1KE4 NKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSM
         . ::: ....:.:: :::.:: : .::..: :: .::..:.:  .::...  .:.:. 
XP_011 RDYYQPLAAKRTEIEKWRKEFKEQWMKEQKRMNEAVQALRRAQLQYVQRSEDL-RARSQG
            60        70        80        90       100        110  

        350       360       370       380       390       400      
pF1KE4 FRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENT
          .    .: :      .:: :..:: .:::  :..::. ::..:: ... :..::: .
XP_011 SPEDSAPQASPGP-----SKQQERRRRSREEAQAKAQEAEALYQACVREANARQQDLEIA
            120            130       140       150       160       

        410       420       430       440       450       460      
pF1KE4 KREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEF
       :..:....: :::: : .:. ::..:: ..  ::     .. .: .    ..:::.:.::
XP_011 KQRIVSHVRKLVFQGDEVLRRVTLSLFGLRGAQAERGPRAFAALAECCAPFEPGQRYQEF
       170       180       190       200       210       220       

        470       480         490       500       510       520    
pF1KE4 VKATNSTEEEKVDG--NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADI
       :.:             . .. : : . : .   ..:     ::    ...:.  .. .  
XP_011 VRALRPEAPPPPPPAFSFQEFLPSLNSSPLDIRKKLSGP--LPP---RLDENS-AEPGPW
       230       240       250       260            270        280 

          530           540       550       560       570       580
pF1KE4 TGPSFIRSW--TFGMF--SDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSAD
         :.    :  : :    :: .:.::.:::::::: . :::   :.: .. :.:: :: :
XP_011 EDPGTGWRWQGTPGPTPGSDVDSVGGGSESRSLDSPTSSPGAGTRQLVKASSTGTESS-D
             290       300       310       320       330        340

              590       600        610       620       630         
pF1KE4 DLDEREPPSPSETGPNSLGT-FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECE
       :..::.: . ..   :.::. : :  .:.:: ::..:.::.:.:::.::...: .:.:::
XP_011 DFEERDP-DLGDGLENGLGSPFGKWTLSSAAQTHQLRRLRGPAKCRECEAFMV-SGTECE
               350       360       370       380       390         

     640       650       660       670       680       690         
pF1KE4 ECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRA
       ::.:.::..:::.:.:.:::..::..  :::..: :. .  :. .::..  :..:::.::
XP_011 ECFLTCHKRCLETLLILCGHRRLPARTPLFGVDFLQLPRDFPEEVPFVVTKCTAEIEHRA
      400       410       420       430       440       450        

     700       710       720       730       740       750         
pF1KE4 LCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRL
       : .:::::: :.....:.::::.:::  ::..:  : ::. .::: .:..: :: : :.:
XP_011 LDVQGIYRVSGSRVRVERLCQAFENGRALVELSGNSPHDVSSVLKRFLQELTEPVIPFHL
      460       470       480       490       500       510        

     760       770       780       790       800       810         
pF1KE4 YKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLH
       :  ::.::: . :..          .:   :.   :. : :   : :: ::: ::.:.:.
XP_011 YDAFISLAKTL-HADPG--------DDPGTPSPSPEVIRSL---KTLLVQLPDSNYNTLR
      520        530               540       550          560      

     820       830       840       850          860       870      
pF1KE4 FLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPR--PTTAP-ITISSLAEYSNQARLVE
        :..:: ::. .  ::::...:::..:::.:.::   : .:  : .. : . ..::.:::
XP_011 HLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCLLDSGHQAQLVE
        570       580       590       600       610       620      

        880       890       900       910            920       930 
pF1KE4 FLITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLS-----PEERDIERSMKSLFFSSK
       :::.. ..::  .  :: .       :..  : :: .     : . : . .   :  .  
XP_011 FLIVHYEQIFGMDELPQAT--EPPPQDSSPAPGPLTTSSQPPPPHLDPDSQPPVLASDPG
        630       640         650       660       670       680    

              940       950       960       970       980       990
pF1KE4 EDI-HTSESESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGK
        :  : :  :..     : .   .  :           : :.   :  .: .::  ::  
XP_011 PDPQHHSTLEQHPTATPTEIPTPQSDQRE---------DVAEDTKDGGGEVSSQGPED--
          690       700       710                720       730     

             1000      1010         1020      1030      1040       
pF1KE4 TPKPLSLKSDRSTNNVERHT---PRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKF
            :: . .: ..  :.    ::  .:::.  .. : :..                  
XP_011 -----SLLGTQSRGHFSRQPVKYPRGGVRPVTHQLSSLALVASKLCEETPITSVPRGSLR
                740       750       760       770       780        

      1050      1060      1070      1080      1090      1100       
pF1KE4 CKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGV
                                                                   
XP_011 GRGPSPAAASPEGSPLRRTPLPKHFEITQETARLLSKLDSEAVPRATCCPDVQPEEAEDH
      790       800       810       820       830       840        

>>XP_016882350 (OMIM: 609694) GEM-interacting protein is  (884 aa)
 initn: 1596 init1: 527 opt: 1170  Z-score: 724.7  bits: 145.8 E(91774): 1.4e-33
Smith-Waterman score: 1664; 38.8% identity (67.7% similar) in 778 aa overlap (129-893:18-764)

      100       110       120       130       140       150        
pF1KE4 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
                                     ....: :...: ...::.  ..: ::    
XP_016              MDAAEPGLPPGPEGRKRYSDIFRSLDNLEISLGNVTLEMLAGD---P
                            10        20        30        40       

      160       170       180       190          200       210     
pF1KE4 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPL---ELDNVLLKNTDSIELALSYAKTW
        : . :   .: .   ..  :  :.    .  ::   :::  :...  ... :: :::::
XP_016 LLSEDPEPDKTPTATVTNEASCWSGPSPEGPVPLTGEELDLRLIRTKGGVDAALEYAKTW
           50        60        70        80        90       100    

         220       230       240       250       260       270     
pF1KE4 SKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSH
       :.:.:....:.::. . ::: ... .:.::: ...:  :  :::: ..:  : .:.  . 
XP_016 SRYAKELLAWTEKRASYELEFAKSTMKIAEAGKVSIQQQSHMPLQYIYTLFLEHDLSLGT
          110       120       130       140       150       160    

         280       290       300       310       320       330     
pF1KE4 LLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQR
       : ..:.:  :   . ::: ....:.:: :::.:: : .::..: :: .::..:.:  .::
XP_016 LAMETVAQ-QKRDYYQPLAAKRTEIEKWRKEFKEQWMKEQKRMNEAVQALRRAQLQYVQR
          170        180       190       200       210       220   

         340       350       360       370       380       390     
pF1KE4 QDEYEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTN
       ...  .:.:.    .    .: :      .:: :..:: .:::  :..::. ::..:: .
XP_016 SEDL-RARSQGSPEDSAPQASPGP-----SKQQERRRRSREEAQAKAQEAEALYQACVRE
            230       240            250       260       270       

         400       410       420       430       440       450     
pF1KE4 VEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAK
       .. :..::: .:..:....: :::: : .:. ::..:: ..  ::     .. .: .   
XP_016 ANARQQDLEIAKQRIVSHVRKLVFQGDEVLRRVTLSLFGLRGAQAERGPRAFAALAECCA
       280       290       300       310       320       330       

         460       470       480         490       500       510   
pF1KE4 LYDPGQEYSEFVKATNSTEEEKVDG--NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKI
        ..:::.:.:::.:             . .. : : . : .   ..:     ::    ..
XP_016 PFEPGQRYQEFVRALRPEAPPPPPPAFSFQEFLPSLNSSPLDIRKKLSGP--LPP---RL
       340       350       360       370       380         390     

           520       530           540       550       560         
pF1KE4 EEDRCSNSADITGPSFIRSW--TFGMF--SDSESTGGSSESRSLDSESISPGDFHRKLPR
       .:.  .. .    :.    :  : :    :: .:.::.:::::::: . :::   :.: .
XP_016 DENS-AEPGPWEDPGTGWRWQGTPGPTPGSDVDSVGGGSESRSLDSPTSSPGAGTRQLVK
             400       410       420       430       440       450 

     570       580       590       600        610       620        
pF1KE4 TPSSGTMSSADDLDEREPPSPSETGPNSLGT-FKKTLMSKAALTHKFRKLRSPTKCRDCE
       . :.:: :: ::..::.: . ..   :.::. : :  .:.:: ::..:.::.:.:::.::
XP_016 ASSTGTESS-DDFEERDP-DLGDGLENGLGSPFGKWTLSSAAQTHQLRRLRGPAKCRECE
             460         470       480       490       500         

      630       640       650       660       670       680        
pF1KE4 GIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFIL
       ...: .:.:::::.:.::..:::.:.:.:::..::..  :::..: :. .  :. .::..
XP_016 AFMV-SGTECEECFLTCHKRCLETLLILCGHRRLPARTPLFGVDFLQLPRDFPEEVPFVV
     510        520       530       540       550       560        

      690       700       710       720       730       740        
pF1KE4 KICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLR
         :..:::.::: .:::::: :.....:.::::.:::  ::..:  : ::. .::: .:.
XP_016 TKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVELSGNSPHDVSSVLKRFLQ
      570       580       590       600       610       620        

      750       760       770       780       790       800        
pF1KE4 QLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLR
       .: :: : :.::  ::.::: . :..          .:   :.   :. : :   : :: 
XP_016 ELTEPVIPFHLYDAFISLAKTL-HADPG--------DDPGTPSPSPEVIRSL---KTLLV
      630       640       650                660       670         

      810       820       830       840       850          860     
pF1KE4 QLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPR--PTTAP-ITISSL
       ::: ::.:.:. :..:: ::. .  ::::...:::..:::.:.::   : .:  : .. :
XP_016 QLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCL
        680       690       700       710       720       730      

         870       880       890       900       910       920     
pF1KE4 AEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKS
        . ..::.::::::.. ..::  .  ::                                
XP_016 LDSGHQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPAPGPLTTSSQPPPPHLDPDSQ
        740       750       760       770       780       790      

>>NP_057657 (OMIM: 609694) GEM-interacting protein isofo  (970 aa)
 initn: 1596 init1: 527 opt: 1170  Z-score: 724.2  bits: 145.8 E(91774): 1.4e-33
Smith-Waterman score: 1676; 36.2% identity (63.4% similar) in 923 aa overlap (129-1029:18-891)

      100       110       120       130       140       150        
pF1KE4 VDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGND
                                     ....: :...: ...::.  ..: ::    
NP_057              MDAAEPGLPPGPEGRKRYSDIFRSLDNLEISLGNVTLEMLAGD---P
                            10        20        30        40       

      160       170       180       190          200       210     
pF1KE4 SLLRLPVSRETKSFENVSVESVDSSSEKGNFSPL---ELDNVLLKNTDSIELALSYAKTW
        : . :   .: .   ..  :  :.    .  ::   :::  :...  ... :: :::::
NP_057 LLSEDPEPDKTPTATVTNEASCWSGPSPEGPVPLTGEELDLRLIRTKGGVDAALEYAKTW
           50        60        70        80        90       100    

         220       230       240       250       260       270     
pF1KE4 SKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSH
       :.:.:....:.::. . ::: ... .:.::: ...:  :  :::: ..:  : .:.  . 
NP_057 SRYAKELLAWTEKRASYELEFAKSTMKIAEAGKVSIQQQSHMPLQYIYTLFLEHDLSLGT
          110       120       130       140       150       160    

         280       290       300       310       320       330     
pF1KE4 LLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQR
       : ..:.:  :   . ::: ....:.:: :::.:: : .::..: :: .::..:.:  .::
NP_057 LAMETVAQ-QKRDYYQPLAAKRTEIEKWRKEFKEQWMKEQKRMNEAVQALRRAQLQYVQR
          170        180       190       200       210       220   

         340       350       360       370       380       390     
pF1KE4 QDEYEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTN
       ...  .:.:.    .    .: :      .:: :..:: .:::  :..::. ::..:: .
NP_057 SEDL-RARSQGSPEDSAPQASPGP-----SKQQERRRRSREEAQAKAQEAEALYQACVRE
            230       240            250       260       270       

         400       410       420       430       440       450     
pF1KE4 VEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAK
       .. :..::: .:..:....: :::: : .:. ::..:: ..  ::     .. .: .   
NP_057 ANARQQDLEIAKQRIVSHVRKLVFQGDEVLRRVTLSLFGLRGAQAERGPRAFAALAECCA
       280       290       300       310       320       330       

         460       470       480         490       500       510   
pF1KE4 LYDPGQEYSEFVKATNSTEEEKVDG--NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKI
        ..:::.:.:::.:             . .. : : . : .   ..:     ::    ..
NP_057 PFEPGQRYQEFVRALRPEAPPPPPPAFSFQEFLPSLNSSPLDIRKKLSGP--LPP---RL
       340       350       360       370       380         390     

           520       530           540       550       560         
pF1KE4 EEDRCSNSADITGPSFIRSW--TFGMF--SDSESTGGSSESRSLDSESISPGDFHRKLPR
       .:.  .. .    :.    :  : :    :: .:.::.:::::::: . :::   :.: .
NP_057 DENS-AEPGPWEDPGTGWRWQGTPGPTPGSDVDSVGGGSESRSLDSPTSSPGAGTRQLVK
             400       410       420       430       440       450 

     570       580       590       600        610       620        
pF1KE4 TPSSGTMSSADDLDEREPPSPSETGPNSLGT-FKKTLMSKAALTHKFRKLRSPTKCRDCE
       . :.:: :: ::..::.: . ..   :.::. : :  .:.:: ::..:.::.:.:::.::
NP_057 ASSTGTESS-DDFEERDP-DLGDGLENGLGSPFGKWTLSSAAQTHQLRRLRGPAKCRECE
             460         470       480       490       500         

      630       640       650       660       670       680        
pF1KE4 GIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFIL
       ...: .:.:::::.:.::..:::.:.:.:::..::..  :::..: :. .  :. .::..
NP_057 AFMV-SGTECEECFLTCHKRCLETLLILCGHRRLPARTPLFGVDFLQLPRDFPEEVPFVV
     510        520       530       540       550       560        

      690       700       710       720       730       740        
pF1KE4 KICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLR
         :..:::.::: .:::::: :.....:.::::.:::  ::..:  : ::. .::: .:.
NP_057 TKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVELSGNSPHDVSSVLKRFLQ
      570       580       590       600       610       620        

      750       760       770       780       790       800        
pF1KE4 QLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLR
       .: :: : :.::  ::.::: . :..          .:   :.   :. : :   : :: 
NP_057 ELTEPVIPFHLYDAFISLAKTL-HADPG--------DDPGTPSPSPEVIRSL---KTLLV
      630       640       650                660       670         

      810       820       830       840       850          860     
pF1KE4 QLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPR--PTTAP-ITISSL
       ::: ::.:.:. :..:: ::. .  ::::...:::..:::.:.::   : .:  : .. :
NP_057 QLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCL
        680       690       700       710       720       730      

         870       880       890       900       910            920
pF1KE4 AEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLS-----PEERDIE
        . ..::.::::::.. ..::  .  :: .       :..  : :: .     : . : .
NP_057 LDSGHQAQLVEFLIVHYEQIFGMDELPQAT--EPPPQDSSPAPGPLTTSSQPPPPHLDPD
        740       750       760         770       780       790    

              930        940       950       960       970         
pF1KE4 RSMKSLFFSSKEDI-HTSESESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEA
        .   :  .   :  : :  :..     : .   .  :           : :.   :  .
NP_057 SQPPVLASDPGPDPQHHSTLEQHPTATPTEIPTPQSDQRE---------DVAEDTKDGGG
          800       810       820       830                840     

     980       990      1000      1010         1020      1030      
pF1KE4 ESASQKIEDGKTPKPLSLKSDRSTNNVERHT---PRTKIRPVSLPVDRLLLASPPNERNG
       : .::  ::       :: . .: ..  :.    ::  .:::.  .. : :..       
NP_057 EVSSQGPED-------SLLGTQSRGHFSRQPVKYPRGGVRPVTHQLSSLALVASKLCEET
         850              860       870       880       890        

       1040      1050      1060      1070      1080      1090      
pF1KE4 RNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTM
                                                                   
NP_057 PITSVPRGSLRGRGPSPAAASPEGSPLRRTPLPKHFEITQETARLLSKLDSEAVPRATCC
      900       910       920       930       940       950        




1261 residues in 1 query   sequences
64092750 residues in 91774 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Tue Jul 16 15:57:33 2019 done: Tue Jul 16 15:57:34 2019
 Total Scan time:  8.000 Total Display time:  0.320

Function used was FASTA [36.3.4 Apr, 2011]
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