Result of FASTA (omim) for pF1KE3557
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE3557, 548 aa
  1>>>pF1KE3557     548 - 548 aa - 548 aa
Library: /omim/omim.rfq.tfa
  64369986 residues in 92320 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.4467+/-0.000328; mu= 5.2232+/- 0.021
 mean_var=193.0917+/-39.611, 0's: 0 Z-trim(121.6): 455  B-trim: 256 in 2/57
 Lambda= 0.092298
 statistics sampled from 39402 (39883) to 39402 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.757), E-opt: 0.2 (0.432), width:  16
 Scan time:  5.530

The best scores are:                                      opt bits E(92320)
NP_954976 (OMIM: 610591) rho GTPase-activating pro ( 548) 3738 510.2 7.2e-144
XP_016879801 (OMIM: 610591) rho GTPase-activating  ( 689) 3738 510.3 8.6e-144
NP_001269219 (OMIM: 610591) rho GTPase-activating  ( 889) 3738 510.3 1.1e-143
XP_006721808 (OMIM: 610591) rho GTPase-activating  ( 889) 3738 510.3 1.1e-143
XP_005257185 (OMIM: 610591) rho GTPase-activating  ( 667) 2674 368.6 3.8e-101
XP_006721810 (OMIM: 610591) rho GTPase-activating  ( 867) 2674 368.7 4.6e-101
XP_011522771 (OMIM: 610591) rho GTPase-activating  ( 900) 1913 267.3 1.5e-70
XP_011522776 (OMIM: 610591) rho GTPase-activating  ( 581) 1888 263.9 1.1e-69
XP_016879802 (OMIM: 610591) rho GTPase-activating  ( 629) 1888 263.9 1.2e-69
XP_006721813 (OMIM: 610591) rho GTPase-activating  ( 615) 1887 263.8 1.2e-69
XP_011522774 (OMIM: 610591) rho GTPase-activating  ( 722) 1888 263.9 1.3e-69
XP_011522772 (OMIM: 610591) rho GTPase-activating  ( 870) 1888 264.0 1.5e-69
XP_011522770 (OMIM: 610591) rho GTPase-activating  ( 922) 1888 264.0 1.6e-69
XP_016879800 (OMIM: 610591) rho GTPase-activating  ( 922) 1888 264.0 1.6e-69
XP_011522773 (OMIM: 610591) rho GTPase-activating  ( 865) 1884 263.5 2.1e-69
XP_011522775 (OMIM: 610591) rho GTPase-activating  ( 587) 1678 235.9 2.9e-61
NP_001257624 (OMIM: 610577) rho GTPase-activating  ( 841) 1431 203.1   3e-51
XP_005252701 (OMIM: 610577) rho GTPase-activating  ( 794) 1376 195.8 4.6e-49
NP_001257628 (OMIM: 610577) rho GTPase-activating  ( 794) 1376 195.8 4.6e-49
XP_016872443 (OMIM: 610577) rho GTPase-activating  ( 742) 1332 189.9 2.5e-47
NP_001257627 (OMIM: 610577) rho GTPase-activating  ( 769) 1325 189.0   5e-47
XP_011518063 (OMIM: 610577) rho GTPase-activating  ( 772) 1296 185.1 7.3e-46
NP_001257626 (OMIM: 610577) rho GTPase-activating  ( 799) 1296 185.1 7.5e-46
NP_060757 (OMIM: 610577) rho GTPase-activating pro ( 846) 1296 185.2 7.8e-46
NP_001257625 (OMIM: 610577) rho GTPase-activating  ( 816) 1293 184.8   1e-45
XP_016859989 (OMIM: 610578) rho GTPase-activating  ( 432) 1218 174.6 6.2e-43
NP_060930 (OMIM: 610578) rho GTPase-activating pro ( 475) 1218 174.6 6.7e-43
XP_011509781 (OMIM: 610578) rho GTPase-activating  ( 475) 1218 174.6 6.7e-43
XP_016859988 (OMIM: 610578) rho GTPase-activating  ( 475) 1218 174.6 6.7e-43
XP_011509785 (OMIM: 610578) rho GTPase-activating  ( 397) 1089 157.4 8.6e-38
XP_011509783 (OMIM: 610578) rho GTPase-activating  ( 435) 1054 152.7 2.3e-36
XP_011509784 (OMIM: 610578) rho GTPase-activating  ( 416) 1038 150.6 9.9e-36
XP_024308768 (OMIM: 610578) rho GTPase-activating  ( 241)  944 137.9 3.8e-32
XP_024308769 (OMIM: 610578) rho GTPase-activating  ( 241)  944 137.9 3.8e-32
NP_001073626 (OMIM: 610576) rho GTPase-activating  ( 640)  710 107.0 1.9e-22
XP_011536961 (OMIM: 610576) rho GTPase-activating  ( 640)  710 107.0 1.9e-22
NP_001354353 (OMIM: 610576) rho GTPase-activating  ( 456)  697 105.2 4.9e-22
NP_001354354 (OMIM: 610576) rho GTPase-activating  ( 425)  696 105.0 5.1e-22
XP_011509786 (OMIM: 610578) rho GTPase-activating  ( 342)  672 101.8   4e-21
XP_016859990 (OMIM: 610578) rho GTPase-activating  ( 341)  544 84.7 5.3e-16
NP_001166101 (OMIM: 614902) rho GTPase-activating  (1123)  486 77.4 2.9e-13
NP_443180 (OMIM: 614902) rho GTPase-activating pro (1126)  486 77.4 2.9e-13
XP_011524718 (OMIM: 614902) rho GTPase-activating  (1161)  486 77.4 2.9e-13
NP_001243776 (OMIM: 600365) active breakpoint clus ( 310)  474 75.4 3.2e-13
NP_001353107 (OMIM: 614902) rho GTPase-activating  (1287)  486 77.4 3.2e-13
XP_011524723 (OMIM: 614902) rho GTPase-activating  ( 703)  479 76.3 3.8e-13
XP_016881727 (OMIM: 614902) rho GTPase-activating  ( 711)  479 76.3 3.8e-13
XP_011524720 (OMIM: 614902) rho GTPase-activating  (1134)  479 76.5 5.5e-13
XP_011524719 (OMIM: 614902) rho GTPase-activating  (1152)  479 76.5 5.6e-13
NP_001269078 (OMIM: 600365) active breakpoint clus ( 641)  474 75.6 5.6e-13


>>NP_954976 (OMIM: 610591) rho GTPase-activating protein  (548 aa)
 initn: 3738 init1: 3738 opt: 3738  Z-score: 2704.5  bits: 510.2 E(92320): 7.2e-144
Smith-Waterman score: 3738; 100.0% identity (100.0% similar) in 548 aa overlap (1-548:1-548)

               10        20        30        40        50        60
pF1KE3 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 QDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 QDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE3 KEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 KEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE3 LCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 LCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE3 EDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 EDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDT
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE3 LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQ
              490       500       510       520       530       540

               
pF1KE3 CADIFPPH
       ::::::::
NP_954 CADIFPPH
               

>>XP_016879801 (OMIM: 610591) rho GTPase-activating prot  (689 aa)
 initn: 3738 init1: 3738 opt: 3738  Z-score: 2703.1  bits: 510.3 E(92320): 8.6e-144
Smith-Waterman score: 3738; 100.0% identity (100.0% similar) in 548 aa overlap (1-548:142-689)

                                             10        20        30
pF1KE3                               MQPGLSPGSPGDPRPPTPETDYPESLTSYP
                                     ::::::::::::::::::::::::::::::
XP_016 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
             120       130       140       150       160       170 

               40        50        60        70        80        90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
             180       190       200       210       220       230 

              100       110       120       130       140       150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
             240       250       260       270       280       290 

              160       170       180       190       200       210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
             300       310       320       330       340       350 

              220       230       240       250       260       270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
             360       370       380       390       400       410 

              280       290       300       310       320       330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
             420       430       440       450       460       470 

              340       350       360       370       380       390
pF1KE3 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
             480       490       500       510       520       530 

              400       410       420       430       440       450
pF1KE3 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
             540       550       560       570       580       590 

              460       470       480       490       500       510
pF1KE3 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
             600       610       620       630       640       650 

              520       530       540        
pF1KE3 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
       ::::::::::::::::::::::::::::::::::::::
XP_016 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
             660       670       680         

>>NP_001269219 (OMIM: 610591) rho GTPase-activating prot  (889 aa)
 initn: 3738 init1: 3738 opt: 3738  Z-score: 2701.5  bits: 510.3 E(92320): 1.1e-143
Smith-Waterman score: 3738; 100.0% identity (100.0% similar) in 548 aa overlap (1-548:342-889)

                                             10        20        30
pF1KE3                               MQPGLSPGSPGDPRPPTPETDYPESLTSYP
                                     ::::::::::::::::::::::::::::::
NP_001 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
             320       330       340       350       360       370 

               40        50        60        70        80        90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
             380       390       400       410       420       430 

              100       110       120       130       140       150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
             440       450       460       470       480       490 

              160       170       180       190       200       210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
             500       510       520       530       540       550 

              220       230       240       250       260       270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
             560       570       580       590       600       610 

              280       290       300       310       320       330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
             620       630       640       650       660       670 

              340       350       360       370       380       390
pF1KE3 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
             680       690       700       710       720       730 

              400       410       420       430       440       450
pF1KE3 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
             740       750       760       770       780       790 

              460       470       480       490       500       510
pF1KE3 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
             800       810       820       830       840       850 

              520       530       540        
pF1KE3 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
       ::::::::::::::::::::::::::::::::::::::
NP_001 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
             860       870       880         

>>XP_006721808 (OMIM: 610591) rho GTPase-activating prot  (889 aa)
 initn: 3738 init1: 3738 opt: 3738  Z-score: 2701.5  bits: 510.3 E(92320): 1.1e-143
Smith-Waterman score: 3738; 100.0% identity (100.0% similar) in 548 aa overlap (1-548:342-889)

                                             10        20        30
pF1KE3                               MQPGLSPGSPGDPRPPTPETDYPESLTSYP
                                     ::::::::::::::::::::::::::::::
XP_006 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
             320       330       340       350       360       370 

               40        50        60        70        80        90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
             380       390       400       410       420       430 

              100       110       120       130       140       150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
             440       450       460       470       480       490 

              160       170       180       190       200       210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
             500       510       520       530       540       550 

              220       230       240       250       260       270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
             560       570       580       590       600       610 

              280       290       300       310       320       330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
             620       630       640       650       660       670 

              340       350       360       370       380       390
pF1KE3 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
             680       690       700       710       720       730 

              400       410       420       430       440       450
pF1KE3 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
             740       750       760       770       780       790 

              460       470       480       490       500       510
pF1KE3 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
             800       810       820       830       840       850 

              520       530       540        
pF1KE3 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
       ::::::::::::::::::::::::::::::::::::::
XP_006 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
             860       870       880         

>>XP_005257185 (OMIM: 610591) rho GTPase-activating prot  (667 aa)
 initn: 2702 init1: 2641 opt: 2674  Z-score: 1937.6  bits: 368.6 E(92320): 3.8e-101
Smith-Waterman score: 3542; 96.0% identity (96.0% similar) in 548 aa overlap (1-548:142-667)

                                             10        20        30
pF1KE3                               MQPGLSPGSPGDPRPPTPETDYPESLTSYP
                                     ::::::::::::::::::::::::::::::
XP_005 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
             120       130       140       150       160       170 

               40        50        60        70        80        90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
             180       190       200       210       220       230 

              100       110       120       130       140       150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
       ::::::::::::::::::::::::::::::::::::::::                    
XP_005 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEK--------------------
             240       250       260       270                     

              160       170       180       190       200       210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 --TKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
               280       290       300       310       320         

              220       230       240       250       260       270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
     330       340       350       360       370       380         

              280       290       300       310       320       330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
     390       400       410       420       430       440         

              340       350       360       370       380       390
pF1KE3 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
     450       460       470       480       490       500         

              400       410       420       430       440       450
pF1KE3 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
     510       520       530       540       550       560         

              460       470       480       490       500       510
pF1KE3 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
     570       580       590       600       610       620         

              520       530       540        
pF1KE3 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
       ::::::::::::::::::::::::::::::::::::::
XP_005 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
     630       640       650       660       

>>XP_006721810 (OMIM: 610591) rho GTPase-activating prot  (867 aa)
 initn: 2711 init1: 2641 opt: 2674  Z-score: 1936.0  bits: 368.7 E(92320): 4.6e-101
Smith-Waterman score: 3542; 96.0% identity (96.0% similar) in 548 aa overlap (1-548:342-867)

                                             10        20        30
pF1KE3                               MQPGLSPGSPGDPRPPTPETDYPESLTSYP
                                     ::::::::::::::::::::::::::::::
XP_006 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
             320       330       340       350       360       370 

               40        50        60        70        80        90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
             380       390       400       410       420       430 

              100       110       120       130       140       150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
       ::::::::::::::::::::::::::::::::::::::::                    
XP_006 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEK--------------------
             440       450       460       470                     

              160       170       180       190       200       210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 --TKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
               480       490       500       510       520         

              220       230       240       250       260       270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
     530       540       550       560       570       580         

              280       290       300       310       320       330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
     590       600       610       620       630       640         

              340       350       360       370       380       390
pF1KE3 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL
     650       660       670       680       690       700         

              400       410       420       430       440       450
pF1KE3 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQF
     710       720       730       740       750       760         

              460       470       480       490       500       510
pF1KE3 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFG
     770       780       790       800       810       820         

              520       530       540        
pF1KE3 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
       ::::::::::::::::::::::::::::::::::::::
XP_006 PTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
     830       840       850       860       

>>XP_011522771 (OMIM: 610591) rho GTPase-activating prot  (900 aa)
 initn: 2795 init1: 1851 opt: 1913  Z-score: 1388.1  bits: 267.3 E(92320): 1.5e-70
Smith-Waterman score: 3466; 90.5% identity (90.5% similar) in 581 aa overlap (1-548:342-900)

                                             10        20        30
pF1KE3                               MQPGLSPGSPGDPRPPTPETDYPESLTSYP
                                     ::::::::::::::::::::::::::::::
XP_011 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
             320       330       340       350       360       370 

               40        50        60        70        80        90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
             380       390       400       410       420       430 

              100       110       120       130       140       150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
       ::::::::::::::::::::::::::::::::::::::::                    
XP_011 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEK--------------------
             440       450       460       470                     

              160       170       180       190       200       210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 --TKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
               480       490       500       510       520         

              220       230       240       250       260       270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
     530       540       550       560       570       580         

                                               280       290       
pF1KE3 QEL---------------------------------SAELPPEESESSRVDFGSSERLGS
       :::                                 ::::::::::::::::::::::::
XP_011 QELGSMQLREVNVLRLTGGGPAAGSRPRLSEAMGIQSAELPPEESESSRVDFGSSERLGS
     590       600       610       620       630       640         

       300       310       320       330       340       350       
pF1KE3 WQEKEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WQEKEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCA
     650       660       670       680       690       700         

       360       370       380       390       400       410       
pF1KE3 LAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDD
     710       720       730       740       750       760         

       420       430       440       450       460       470       
pF1KE3 GRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPN
     770       780       790       800       810       820         

       480       490       500       510       520       530       
pF1KE3 HDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELI
     830       840       850       860       870       880         

       540        
pF1KE3 LQQCADIFPPH
       :::::::::::
XP_011 LQQCADIFPPH
     890       900

>>XP_011522776 (OMIM: 610591) rho GTPase-activating prot  (581 aa)
 initn: 1888 init1: 1888 opt: 1888  Z-score: 1372.8  bits: 263.9 E(92320): 1.1e-69
Smith-Waterman score: 3662; 94.3% identity (94.3% similar) in 581 aa overlap (1-548:1-581)

               10        20        30        40        50        60
pF1KE3 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 QDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLE
              190       200       210       220       230       240

              250       260       270                              
pF1KE3 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQEL---------------------------
       :::::::::::::::::::::::::::::::::                           
XP_011 LRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELGSMQLREVNVLRLTGGGPAAGSRPRLS
              250       260       270       280       290       300

                 280       290       300       310       320       
pF1KE3 ------SAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVR
             ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAMGIQSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVR
              310       320       330       340       350       360

       330       340       350       360       370       380       
pF1KE3 HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDI
              370       380       390       400       410       420

       390       400       410       420       430       440       
pF1KE3 DGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHF
              430       440       450       460       470       480

       450       460       470       480       490       500       
pF1KE3 RQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAI
              490       500       510       520       530       540

       510       520       530       540        
pF1KE3 VFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
       :::::::::::::::::::::::::::::::::::::::::
XP_011 VFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
              550       560       570       580 

>>XP_016879802 (OMIM: 610591) rho GTPase-activating prot  (629 aa)
 initn: 1958 init1: 1888 opt: 1888  Z-score: 1372.3  bits: 263.9 E(92320): 1.2e-69
Smith-Waterman score: 1888; 99.6% identity (100.0% similar) in 274 aa overlap (1-274:342-615)

                                             10        20        30
pF1KE3                               MQPGLSPGSPGDPRPPTPETDYPESLTSYP
                                     ::::::::::::::::::::::::::::::
XP_016 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
             320       330       340       350       360       370 

               40        50        60        70        80        90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
             380       390       400       410       420       430 

              100       110       120       130       140       150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
             440       450       460       470       480       490 

              160       170       180       190       200       210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
             500       510       520       530       540       550 

              220       230       240       250       260       270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
             560       570       580       590       600       610 

              280       290       300       310       320       330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
       :::.                                                        
XP_016 QELAHWWRTRSWLKAPPL                                          
             620                                                   

>>XP_006721813 (OMIM: 610591) rho GTPase-activating prot  (615 aa)
 initn: 1887 init1: 1887 opt: 1887  Z-score: 1371.7  bits: 263.8 E(92320): 1.2e-69
Smith-Waterman score: 1887; 100.0% identity (100.0% similar) in 273 aa overlap (1-273:342-614)

                                             10        20        30
pF1KE3                               MQPGLSPGSPGDPRPPTPETDYPESLTSYP
                                     ::::::::::::::::::::::::::::::
XP_006 ESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYP
             320       330       340       350       360       370 

               40        50        60        70        80        90
pF1KE3 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYN
             380       390       400       410       420       430 

              100       110       120       130       140       150
pF1KE3 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAA
             440       450       460       470       480       490 

              160       170       180       190       200       210
pF1KE3 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSK
             500       510       520       530       540       550 

              220       230       240       250       260       270
pF1KE3 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGI
             560       570       580       590       600       610 

              280       290       300       310       320       330
pF1KE3 QELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKL
       :::                                                         
XP_006 QELR                                                        
                                                                   




548 residues in 1 query   sequences
64369986 residues in 92320 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Oct 24 21:33:16 2019 done: Thu Oct 24 21:33:17 2019
 Total Scan time:  5.530 Total Display time:  0.110

Function used was FASTA [36.3.4 Apr, 2011]
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