Result of FASTA (omim) for pF1KE1590
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE1590, 1168 aa
  1>>>pF1KE1590 1168 - 1168 aa - 1168 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.6585+/-0.000387; mu= 12.5575+/- 0.024
 mean_var=160.2731+/-33.378, 0's: 0 Z-trim(117.7): 206  B-trim: 1401 in 1/53
 Lambda= 0.101308
 statistics sampled from 29748 (29972) to 29748 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.351), width:  16
 Scan time: 16.860

The best scores are:                                      opt bits E(85289)
NP_055988 (OMIM: 609850) TBC1 domain family member (1168) 7754 1146.3       0
XP_016863410 (OMIM: 609850) PREDICTED: TBC1 domain (1039) 6804 1007.4       0
XP_011511968 (OMIM: 609850) PREDICTED: TBC1 domain (1188) 5801 860.8       0
XP_016863409 (OMIM: 609850) PREDICTED: TBC1 domain (1181) 4567 680.5 1.7e-194
XP_016863408 (OMIM: 609850) PREDICTED: TBC1 domain (1222) 4243 633.1 3.1e-180
NP_001240841 (OMIM: 609850) TBC1 domain family mem (1159) 4238 632.4 4.9e-180
XP_005262704 (OMIM: 609850) PREDICTED: TBC1 domain (1262) 4238 632.4 5.3e-180
XP_005262703 (OMIM: 609850) PREDICTED: TBC1 domain (1275) 4238 632.4 5.3e-180
XP_006714064 (OMIM: 609850) PREDICTED: TBC1 domain ( 546) 3612 540.7 9.6e-153
XP_011511965 (OMIM: 609850) PREDICTED: TBC1 domain (1242) 3568 534.5 1.6e-150
XP_016863407 (OMIM: 609850) PREDICTED: TBC1 domain (1228) 3517 527.0 2.7e-148
XP_011511962 (OMIM: 609850) PREDICTED: TBC1 domain (1282) 3517 527.0 2.8e-148
XP_005262706 (OMIM: 609850) PREDICTED: TBC1 domain (1146) 3288 493.5 3.1e-138
XP_011511961 (OMIM: 609850) PREDICTED: TBC1 domain (1295) 3212 482.5 7.5e-135
XP_011511967 (OMIM: 609850) PREDICTED: TBC1 domain (1201) 3205 481.4 1.4e-134
XP_011511966 (OMIM: 609850) PREDICTED: TBC1 domain (1241) 3205 481.4 1.5e-134
XP_011511964 (OMIM: 609850) PREDICTED: TBC1 domain (1255) 3205 481.4 1.5e-134
XP_011511972 (OMIM: 609850) PREDICTED: TBC1 domain ( 494) 3193 479.4 2.4e-134
XP_016876371 (OMIM: 612465,616087) PREDICTED: TBC1 (1054) 2315 351.3 1.9e-95
NP_001273588 (OMIM: 612465,616087) TBC1 domain fam (1235) 2315 351.4 2.1e-95
XP_016876372 (OMIM: 612465,616087) PREDICTED: TBC1 (1017) 2290 347.6 2.3e-94
XP_011511970 (OMIM: 609850) PREDICTED: TBC1 domain ( 812) 2285 346.8 3.2e-94
XP_016863411 (OMIM: 609850) PREDICTED: TBC1 domain ( 939) 2285 346.9 3.6e-94
XP_005266662 (OMIM: 612465,616087) PREDICTED: TBC1 (1117) 2179 331.4 1.9e-89
XP_006719966 (OMIM: 612465,616087) PREDICTED: TBC1 (1140) 2179 331.4 1.9e-89
XP_011533633 (OMIM: 612465,616087) PREDICTED: TBC1 (1261) 2179 331.5 2.1e-89
XP_005266660 (OMIM: 612465,616087) PREDICTED: TBC1 (1273) 2179 331.5 2.1e-89
NP_055647 (OMIM: 612465,616087) TBC1 domain family (1298) 2179 331.5 2.1e-89
NP_001273587 (OMIM: 612465,616087) TBC1 domain fam (1290) 2175 330.9 3.1e-89
XP_016876373 (OMIM: 612465,616087) PREDICTED: TBC1 ( 487) 2026 308.8 5.3e-83
NP_001240843 (OMIM: 609850) TBC1 domain family mem ( 265) 1701 261.1 6.6e-69
NP_001240842 (OMIM: 609850) TBC1 domain family mem ( 265) 1701 261.1 6.6e-69
NP_001240844 (OMIM: 609850) TBC1 domain family mem ( 180) 1118 175.8 2.2e-43
XP_011516744 (OMIM: 615882) PREDICTED: rab GTPase- ( 900)  732 119.9 7.3e-26
XP_016870059 (OMIM: 615882) PREDICTED: rab GTPase- ( 900)  732 119.9 7.3e-26
XP_016870058 (OMIM: 615882) PREDICTED: rab GTPase- (1069)  732 119.9 8.4e-26
XP_016870056 (OMIM: 615882) PREDICTED: rab GTPase- (1069)  732 119.9 8.4e-26
XP_016870057 (OMIM: 615882) PREDICTED: rab GTPase- (1069)  732 119.9 8.4e-26
XP_011516742 (OMIM: 615882) PREDICTED: rab GTPase- (1069)  732 119.9 8.4e-26
NP_036329 (OMIM: 615882) rab GTPase-activating pro (1069)  732 119.9 8.4e-26
XP_011516743 (OMIM: 615882) PREDICTED: rab GTPase- (1069)  732 119.9 8.4e-26
XP_006711756 (OMIM: 609238) PREDICTED: rab GTPase- ( 985)  681 112.5 1.4e-23
XP_005245738 (OMIM: 609238) PREDICTED: rab GTPase- (1014)  681 112.5 1.4e-23
XP_005245737 (OMIM: 609238) PREDICTED: rab GTPase- (1051)  681 112.5 1.4e-23
XP_011508525 (OMIM: 609238) PREDICTED: rab GTPase- (1051)  681 112.5 1.4e-23
XP_016858483 (OMIM: 609238) PREDICTED: rab GTPase- ( 778)  629 104.8 2.2e-21
NP_055672 (OMIM: 609238) rab GTPase-activating pro ( 815)  629 104.8 2.3e-21
XP_016857771 (OMIM: 602942) PREDICTED: ecotropic v ( 812)  593 99.5 8.8e-20
XP_016857761 (OMIM: 602942) PREDICTED: ecotropic v ( 897)  593 99.6 9.5e-20
XP_016857759 (OMIM: 602942) PREDICTED: ecotropic v ( 927)  593 99.6 9.8e-20


>>NP_055988 (OMIM: 609850) TBC1 domain family member 1 i  (1168 aa)
 initn: 7754 init1: 7754 opt: 7754  Z-score: 6130.4  bits: 1146.3 E(85289):    0
Smith-Waterman score: 7754; 99.9% identity (99.9% similar) in 1168 aa overlap (1-1168:1-1168)

               10        20        30        40        50        60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
       ::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
NP_055 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE1 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE1 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE1 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE1 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGTPVKTRRHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGTPVKTRRHS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE1 WRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSREL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 WRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSREL
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE1 RELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLST
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE1 PGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQ
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE1 LTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGIL
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE1 LLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEI
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE1 GPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLE
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE1 TIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRM
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE1 DKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALL
             1090      1100      1110      1120      1130      1140

             1150      1160        
pF1KE1 QTVEELRRRSAEPSDREPECTQPEPTGD
       ::::::::::::::::::::::::::::
NP_055 QTVEELRRRSAEPSDREPECTQPEPTGD
             1150      1160        

>>XP_016863410 (OMIM: 609850) PREDICTED: TBC1 domain fam  (1039 aa)
 initn: 6804 init1: 6804 opt: 6804  Z-score: 5380.7  bits: 1007.4 E(85289):    0
Smith-Waterman score: 6804; 99.9% identity (99.9% similar) in 1030 aa overlap (139-1168:10-1039)

      110       120       130       140       150       160        
pF1KE1 HDPSYFACLIKEDAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDT
                                     ::::::::::::::::::::::::::::::
XP_016                      MSPLFSWVAKVPEIISSIRQAGKIARQEELHCPSEFDDT
                                    10        20        30         

      170       180       190       200       210       220        
pF1KE1 FSKKFEVLFCGRVTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: 
XP_016 FSKKFEVLFCGRVTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPV
      40        50        60        70        80        90         

      230       240       250       260       270       280        
pF1KE1 RRPMRKSFSQPGLRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRPMRKSFSQPGLRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEEN
     100       110       120       130       140       150         

      290       300       310       320       330       340        
pF1KE1 RTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFV
     160       170       180       190       200       210         

      350       360       370       380       390       400        
pF1KE1 CYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSS
     220       230       240       250       260       270         

      410       420       430       440       450       460        
pF1KE1 KTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGE
     280       290       300       310       320       330         

      470       480       490       500       510       520        
pF1KE1 MKQTSQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKQTSQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISV
     340       350       360       370       380       390         

      530       540       550       560       570       580        
pF1KE1 DLDSSLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDSSLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQ
     400       410       420       430       440       450         

      590       600       610       620       630       640        
pF1KE1 AFRRRANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFRRRANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGD
     460       470       480       490       500       510         

      650       660       670       680       690       700        
pF1KE1 SGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGP
     520       530       540       550       560       570         

      710       720       730       740       750       760        
pF1KE1 PPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLK
     580       590       600       610       620       630         

      770       780       790       800       810       820        
pF1KE1 EVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQ
     640       650       660       670       680       690         

      830       840       850       860       870       880        
pF1KE1 PKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVG
     700       710       720       730       740       750         

      890       900       910       920       930       940        
pF1KE1 YCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYH
     760       770       780       790       800       810         

      950       960       970       980       990      1000        
pF1KE1 RDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGS
     820       830       840       850       860       870         

     1010      1020      1030      1040      1050      1060        
pF1KE1 HKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEEL
     880       890       900       910       920       930         

     1070      1080      1090      1100      1110      1120        
pF1KE1 IDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQA
     940       950       960       970       980       990         

     1130      1140      1150      1160        
pF1KE1 MLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
       ::::::::::::::::::::::::::::::::::::::::
XP_016 MLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
    1000      1010      1020      1030         

>>XP_011511968 (OMIM: 609850) PREDICTED: TBC1 domain fam  (1188 aa)
 initn: 5764 init1: 5764 opt: 5801  Z-score: 4587.6  bits: 860.8 E(85289):    0
Smith-Waterman score: 7704; 98.2% identity (98.2% similar) in 1188 aa overlap (1-1168:1-1188)

               10        20        30        40        50        60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
       ::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_011 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
              190       200       210       220       230       240

              250       260       270       280       290          
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFT------
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::      
XP_011 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTKDKSKR
              250       260       270       280       290       300

                        300       310       320       330       340
pF1KE1 --------------IGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESS
                     ::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPATLCWLKYSSETIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESS
              310       320       330       340       350       360

              350       360       370       380       390       400
pF1KE1 GGGGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGGGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCE
              370       380       390       400       410       420

              410       420       430       440       450       460
pF1KE1 RIEGMNSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIEGMNSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQ
              430       440       450       460       470       480

              470       480       490       500       510       520
pF1KE1 KEHIHIGEMKQTSQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEHIHIGEMKQTSQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARG
              490       500       510       520       530       540

              530       540       550       560       570       580
pF1KE1 LQEHSISVDLDSSLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQEHSISVDLDSSLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEE
              550       560       570       580       590       600

              590       600       610       620       630       640
pF1KE1 PAPLSPQQAFRRRANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAPLSPQQAFRRRANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFE
              610       620       630       640       650       660

              650       660       670       680       690       700
pF1KE1 SKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPV
              670       680       690       700       710       720

              710       720       730       740       750       760
pF1KE1 CEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDY
              730       740       750       760       770       780

              770       780       790       800       810       820
pF1KE1 EEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLK
              790       800       810       820       830       840

              830       840       850       860       870       880
pF1KE1 HQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAY
              850       860       870       880       890       900

              890       900       910       920       930       940
pF1KE1 SLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQL
              910       920       930       940       950       960

              950       960       970       980       990      1000
pF1KE1 SRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFK
              970       980       990      1000      1010      1020

             1010      1020      1030      1040      1050      1060
pF1KE1 VALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVE
             1030      1040      1050      1060      1070      1080

             1070      1080      1090      1100      1110      1120
pF1KE1 YHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLS
             1090      1100      1110      1120      1130      1140

             1130      1140      1150      1160        
pF1KE1 SESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
       ::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
             1150      1160      1170      1180        

>>XP_016863409 (OMIM: 609850) PREDICTED: TBC1 domain fam  (1181 aa)
 initn: 4564 init1: 4564 opt: 4567  Z-score: 3612.9  bits: 680.5 E(85289): 1.7e-194
Smith-Waterman score: 7718; 98.8% identity (98.8% similar) in 1181 aa overlap (1-1168:1-1181)

               10        20        30        40        50        60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
       ::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_016 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE1 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE1 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE1 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE1 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGTPVKTRRHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGTPVKTRRHS
              610       620       630       640       650       660

              670       680                    690       700       
pF1KE1 WRQQIFLRVATPQKACDSSSRYE-------------DYSELGELPPRSPLEPVCEDGPFG
       :::::::::::::::::::::::             ::::::::::::::::::::::::
XP_016 WRQQIFLRVATPQKACDSSSRYEEPHCGSPSLACTEDYSELGELPPRSPLEPVCEDGPFG
              670       680       690       700       710       720

       710       720       730       740       750       760       
pF1KE1 PPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCL
              730       740       750       760       770       780

       770       780       790       800       810       820       
pF1KE1 KEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQ
              790       800       810       820       830       840

       830       840       850       860       870       880       
pF1KE1 QPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEV
              850       860       870       880       890       900

       890       900       910       920       930       940       
pF1KE1 GYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDY
              910       920       930       940       950       960

       950       960       970       980       990      1000       
pF1KE1 HRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLG
              970       980       990      1000      1010      1020

      1010      1020      1030      1040      1050      1060       
pF1KE1 SHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEE
             1030      1040      1050      1060      1070      1080

      1070      1080      1090      1100      1110      1120       
pF1KE1 LIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQ
             1090      1100      1110      1120      1130      1140

      1130      1140      1150      1160        
pF1KE1 AMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
       :::::::::::::::::::::::::::::::::::::::::
XP_016 AMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
             1150      1160      1170      1180 

>>XP_016863408 (OMIM: 609850) PREDICTED: TBC1 domain fam  (1222 aa)
 initn: 4238 init1: 4238 opt: 4243  Z-score: 3356.8  bits: 633.1 E(85289): 3.1e-180
Smith-Waterman score: 7472; 95.3% identity (95.4% similar) in 1200 aa overlap (1-1146:1-1200)

               10        20        30        40        50        60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
       ::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_016 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE1 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE1 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE1 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
              550       560       570       580       590       600

              610       620       630                              
pF1KE1 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHER------------------------
       ::::::::::::::::::::::::::::::::::::                        
XP_016 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESKHRPGQSSAPAPPP
              610       620       630       640       650       660

                                      640       650       660      
pF1KE1 ------------------------------KDFESKANHLGDSGGTPVKTRRHSWRQQIF
                                     .:::::::::::::::::::::::::::::
XP_016 RLNPSASSPNFFKYLKHNSSGEQSGNAVPKRDFESKANHLGDSGGTPVKTRRHSWRQQIF
              670       680       690       700       710       720

        670       680       690       700       710       720      
pF1KE1 LRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQK
              730       740       750       760       770       780

        730       740       750       760       770       780      
pF1KE1 AILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKI
              790       800       810       820       830       840

        790       800       810       820       830       840      
pF1KE1 KFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQH
              850       860       870       880       890       900

        850       860       870       880       890       900      
pF1KE1 AILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSE
              910       920       930       940       950       960

        910       920       930       940       950       960      
pF1KE1 EEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYA
              970       980       990      1000      1010      1020

        970       980       990      1000      1010      1020      
pF1KE1 APWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFI
             1030      1040      1050      1060      1070      1080

       1030      1040      1050      1060      1070      1080      
pF1KE1 KSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKT
             1090      1100      1110      1120      1130      1140

       1090      1100      1110      1120      1130      1140      
pF1KE1 NSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEEL
             1150      1160      1170      1180      1190      1200

       1150      1160        
pF1KE1 RRRSAEPSDREPECTQPEPTGD
                             
XP_016 RRRSAEPSDREPECTQPEPTGD
             1210      1220  

>>NP_001240841 (OMIM: 609850) TBC1 domain family member   (1159 aa)
 initn: 6242 init1: 4238 opt: 4238  Z-score: 3353.1  bits: 632.4 E(85289): 4.9e-180
Smith-Waterman score: 6655; 84.2% identity (84.3% similar) in 1262 aa overlap (1-1168:1-1159)

               10        20        30        40        50        60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
       ::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
NP_001 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE1 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE1 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE1 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
              550       560       570       580       590       600

              610       620       630                              
pF1KE1 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHER------------------------
       ::::::::::::::::::::::::::::::::::::                        
NP_001 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESKHRPGQSSAPAPPP
              610       620       630       640       650       660

                                                                   
pF1KE1 ------------------------------------------------------------
                                                                   
NP_001 RLNPSASSPNFFKYLKHNSSGEQSGNAVPKSISYRNALRKKLHSSSSVPNFLKFLAPVDE
              670       680       690       700       710       720

                  640       650       660       670       680      
pF1KE1 ----------KDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYS
                 .:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NNTSDFMNTKRDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYS
              730       740       750       760       770       780

        690       700       710       720       730       740      
pF1KE1 ELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQA
              790       800       810       820       830       840

        750       760       770       780       790       800      
pF1KE1 SENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHR
              850       860       870       880       890       900

        810       820       830       840       850       860      
pF1KE1 GEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQL
              910       920       930       940       950       960

        870       880       890       900       910       920      
pF1KE1 GAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQY
              970       980       990      1000      1010      1020

        930       940       950       960       970       980      
pF1KE1 RPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARV
       ::::::::                                                    
NP_001 RPDMIILQ----------------------------------------------------
                                                                   

        990      1000      1010      1020      1030      1040      
pF1KE1 FDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVF
                                                          :::::::::
NP_001 ---------------------------------------------------MEKTINQVF
                                                        1030       

       1050      1060      1070      1080      1090      1100      
pF1KE1 EMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANG
      1040      1050      1060      1070      1080      1090       

       1110      1120      1130      1140      1150      1160      
pF1KE1 RIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPT
      1100      1110      1120      1130      1140      1150       

         
pF1KE1 GD
       ::
NP_001 GD
         

>>XP_005262704 (OMIM: 609850) PREDICTED: TBC1 domain fam  (1262 aa)
 initn: 4238 init1: 4238 opt: 4238  Z-score: 3352.6  bits: 632.4 E(85289): 5.3e-180
Smith-Waterman score: 7170; 92.0% identity (92.1% similar) in 1200 aa overlap (1-1106:1-1200)

               10        20        30        40        50        60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
       ::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_005 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE1 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE1 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE1 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
              550       560       570       580       590       600

              610       620       630                              
pF1KE1 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHER------------------------
       ::::::::::::::::::::::::::::::::::::                        
XP_005 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESKHRPGQSSAPAPPP
              610       620       630       640       650       660

                                                                   
pF1KE1 ------------------------------------------------------------
                                                                   
XP_005 RLNPSASSPNFFKYLKHNSSGEQSGNAVPKSISYRNALRKKLHSSSSVPNFLKFLAPVDE
              670       680       690       700       710       720

                  640       650       660       670       680      
pF1KE1 ----------KDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYS
                 .:::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NNTSDFMNTKRDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYS
              730       740       750       760       770       780

        690       700       710       720       730       740      
pF1KE1 ELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQA
              790       800       810       820       830       840

        750       760       770       780       790       800      
pF1KE1 SENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHR
              850       860       870       880       890       900

        810       820       830       840       850       860      
pF1KE1 GEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQL
              910       920       930       940       950       960

        870       880       890       900       910       920      
pF1KE1 GAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQY
              970       980       990      1000      1010      1020

        930       940       950       960       970       980      
pF1KE1 RPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARV
             1030      1040      1050      1060      1070      1080

        990      1000      1010      1020      1030      1040      
pF1KE1 FDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVF
             1090      1100      1110      1120      1130      1140

       1050      1060      1070      1080      1090      1100      
pF1KE1 EMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANG
             1150      1160      1170      1180      1190      1200

       1110      1120      1130      1140      1150      1160      
pF1KE1 RIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPT
                                                                   
XP_005 RIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPT
             1210      1220      1230      1240      1250      1260

>--
 initn: 383 init1: 383 opt: 383  Z-score: 307.6  bits: 69.0 E(85289): 2.2e-10
Smith-Waterman score: 383; 100.0% identity (100.0% similar) in 62 aa overlap (1107-1168:1201-1262)

       1080      1090      1100      1110      1120      1130      
pF1KE1 NQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELER
                                     ::::::::::::::::::::::::::::::
XP_005 NQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELER
             1180      1190      1200      1210      1220      1230

       1140      1150      1160        
pF1KE1 SALLQTVEELRRRSAEPSDREPECTQPEPTGD
       ::::::::::::::::::::::::::::::::
XP_005 SALLQTVEELRRRSAEPSDREPECTQPEPTGD
             1240      1250      1260  

>>XP_005262703 (OMIM: 609850) PREDICTED: TBC1 domain fam  (1275 aa)
 initn: 7422 init1: 4238 opt: 4238  Z-score: 3352.6  bits: 632.4 E(85289): 5.3e-180
Smith-Waterman score: 7054; 90.9% identity (91.0% similar) in 1200 aa overlap (1-1093:1-1200)

               10        20        30        40        50        60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
       ::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_005 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE1 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE1 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE1 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
              550       560       570       580       590       600

              610       620       630                              
pF1KE1 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHER------------------------
       ::::::::::::::::::::::::::::::::::::                        
XP_005 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESKHRPGQSSAPAPPP
              610       620       630       640       650       660

                                                                   
pF1KE1 ------------------------------------------------------------
                                                                   
XP_005 RLNPSASSPNFFKYLKHNSSGEQSGNAVPKSISYRNALRKKLHSSSSVPNFLKFLAPVDE
              670       680       690       700       710       720

                  640       650       660       670       680      
pF1KE1 ----------KDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYE---
                 .::::::::::::::::::::::::::::::::::::::::::::::   
XP_005 NNTSDFMNTKRDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEEPH
              730       740       750       760       770       780

                     690       700       710       720       730   
pF1KE1 ----------DYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQIL
                 ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CGSPSLACTEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQIL
              790       800       810       820       830       840

           740       750       760       770       780       790   
pF1KE1 LLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKM
              850       860       870       880       890       900

           800       810       820       830       840       850   
pF1KE1 HSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLG
              910       920       930       940       950       960

           860       870       880       890       900       910   
pF1KE1 RTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKML
              970       980       990      1000      1010      1020

           920       930       940       950       960       970   
pF1KE1 KFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTM
             1030      1040      1050      1060      1070      1080

           980       990      1000      1010      1020      1030   
pF1KE1 FASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNL
             1090      1100      1110      1120      1130      1140

          1040      1050      1060      1070      1080      1090   
pF1KE1 GLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQ
             1150      1160      1170      1180      1190      1200

          1100      1110      1120      1130      1140      1150   
pF1KE1 NLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEP
                                                                   
XP_005 NLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEP
             1210      1220      1230      1240      1250      1260

>--
 initn: 463 init1: 463 opt: 463  Z-score: 370.7  bits: 80.7 E(85289): 6.6e-14
Smith-Waterman score: 463; 100.0% identity (100.0% similar) in 75 aa overlap (1094-1168:1201-1275)

          1070      1080      1090      1100      1110      1120   
pF1KE1 LQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSES
                                     ::::::::::::::::::::::::::::::
XP_005 LQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSES
             1180      1190      1200      1210      1220      1230

          1130      1140      1150      1160        
pF1KE1 KLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
       :::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
             1240      1250      1260      1270     

>>XP_006714064 (OMIM: 609850) PREDICTED: TBC1 domain fam  (546 aa)
 initn: 3612 init1: 3612 opt: 3612  Z-score: 2863.2  bits: 540.7 E(85289): 9.6e-153
Smith-Waterman score: 3612; 100.0% identity (100.0% similar) in 546 aa overlap (623-1168:1-546)

            600       610       620       630       640       650  
pF1KE1 RANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGT
                                     ::::::::::::::::::::::::::::::
XP_006                               MRYHSVSTETPHERKDFESKANHLGDSGGT
                                             10        20        30

            660       670       680       690       700       710  
pF1KE1 PVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEE
               40        50        60        70        80        90

            720       730       740       750       760       770  
pF1KE1 KKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTT
              100       110       120       130       140       150

            780       790       800       810       820       830  
pF1KE1 VWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDV
              160       170       180       190       200       210

            840       850       860       870       880       890  
pF1KE1 PYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQG
              220       230       240       250       260       270

            900       910       920       930       940       950  
pF1KE1 LSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLY
              280       290       300       310       320       330

            960       970       980       990      1000      1010  
pF1KE1 NHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPL
              340       350       360       370       380       390

           1020      1030      1040      1050      1060      1070  
pF1KE1 ILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSS
              400       410       420       430       440       450

           1080      1090      1100      1110      1120      1130  
pF1KE1 PLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTL
              460       470       480       490       500       510

           1140      1150      1160        
pF1KE1 ELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
       ::::::::::::::::::::::::::::::::::::
XP_006 ELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
              520       530       540      

>>XP_011511965 (OMIM: 609850) PREDICTED: TBC1 domain fam  (1242 aa)
 initn: 5501 init1: 3516 opt: 3568  Z-score: 2823.5  bits: 534.5 E(85289): 1.6e-150
Smith-Waterman score: 7303; 93.7% identity (93.8% similar) in 1200 aa overlap (43-1168:43-1242)

             20        30        40        50        60        70  
pF1KE1 LSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPVTKQVRLCVSPSG
                                     ::::::::::::::::::::::::::::::
XP_011 LSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPVTKQVRLCVSPSG
             20        30        40        50        60        70  

             80        90       100       110       120       130  
pF1KE1 LRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKEDAVHRQSICYVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKEDAVHRQSICYVF
             80        90       100       110       120       130  

            140       150       160       170       180       190  
pF1KE1 KADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGRVTVAHKKAPPAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGRVTVAHKKAPPAL
            140       150       160       170       180       190  

            200       210       220       230       240       250  
pF1KE1 IDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPGLRSLAFRKELQD
       ::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::
XP_011 IDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPGLRSLAFRKELQD
            200       210       220       230       240       250  

            260       270       280       290                      
pF1KE1 GGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFT------------------
       ::::::::::::::::::::::::::::::::::::::::::                  
XP_011 GGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTKDKSKRLPATLCWLKYSS
            260       270       280       290       300       310  

            300       310       320       330       340       350  
pF1KE1 --IGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVF
         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVF
            320       330       340       350       360       370  

            360       370       380       390       400       410  
pF1KE1 QCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKL
            380       390       400       410       420       430  

            420       430       440       450       460       470  
pF1KE1 ELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQT
            440       450       460       470       480       490  

            480       490       500       510       520       530  
pF1KE1 SQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDS
            500       510       520       530       540       550  

            540       550       560       570       580       590  
pF1KE1 SLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRR
            560       570       580       590       600       610  

            600       610       620       630                      
pF1KE1 RANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHER----------------
       ::::::::::::::::::::::::::::::::::::::::::::                
XP_011 RANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESKHRPGQ
            620       630       640       650       660       670  

                                              640       650        
pF1KE1 --------------------------------------KDFESKANHLGDSGGTPVKTRR
                                             .:::::::::::::::::::::
XP_011 SSAPAPPPRLNPSASSPNFFKYLKHNSSGEQSGNAVPKRDFESKANHLGDSGGTPVKTRR
            680       690       700       710       720       730  

      660       670       680       690       700       710        
pF1KE1 HSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSR
            740       750       760       770       780       790  

      720       730       740       750       760       770        
pF1KE1 ELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKML
            800       810       820       830       840       850  

      780       790       800       810       820       830        
pF1KE1 STPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELL
            860       870       880       890       900       910  

      840       850       860       870       880       890        
pF1KE1 KQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAG
            920       930       940       950       960       970  

      900       910       920       930       940       950        
pF1KE1 ILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEH
            980       990      1000      1010      1020      1030  

      960       970       980       990      1000      1010        
pF1KE1 EIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHEN
           1040      1050      1060      1070      1080      1090  

     1020      1030      1040      1050      1060      1070        
pF1KE1 LETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQ
           1100      1110      1120      1130      1140      1150  

     1080      1090      1100      1110      1120      1130        
pF1KE1 RMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSA
           1160      1170      1180      1190      1200      1210  

     1140      1150      1160        
pF1KE1 LLQTVEELRRRSAEPSDREPECTQPEPTGD
       ::::::::::::::::::::::::::::::
XP_011 LLQTVEELRRRSAEPSDREPECTQPEPTGD
           1220      1230      1240  

>--
 initn: 280 init1: 280 opt: 280  Z-score: 226.3  bits: 53.9 E(85289): 7.2e-06
Smith-Waterman score: 280; 100.0% identity (100.0% similar) in 42 aa overlap (1-42:1-42)

               10        20        30        40        50        60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
       ::::::::::::::::::::::::::::::::::::::::::                  
XP_011 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
                                                                   
XP_011 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
               70        80        90       100       110       120




1168 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 19:35:23 2016 done: Sat Nov  5 19:35:25 2016
 Total Scan time: 16.860 Total Display time:  0.520

Function used was FASTA [36.3.4 Apr, 2011]
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