Result of FASTA (omim) for pF1KE1022
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE1022, 730 aa
  1>>>pF1KE1022 730 - 730 aa - 730 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.6393+/-0.000362; mu= 1.7751+/- 0.023
 mean_var=247.0370+/-50.803, 0's: 0 Z-trim(122.6): 63  B-trim: 2664 in 2/55
 Lambda= 0.081601
 statistics sampled from 40797 (40871) to 40797 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.775), E-opt: 0.2 (0.479), width:  16
 Scan time: 11.840

The best scores are:                                      opt bits E(85289)
NP_940997 (OMIM: 608252) actin filament-associated ( 730) 4815 580.1 1.1e-164
XP_006713972 (OMIM: 608252) PREDICTED: actin filam ( 751) 4815 580.1 1.1e-164
XP_016864024 (OMIM: 608252) PREDICTED: actin filam ( 748) 3457 420.2 1.5e-116
XP_016864025 (OMIM: 608252) PREDICTED: actin filam ( 555) 3425 416.3 1.6e-115
XP_011511846 (OMIM: 608252) PREDICTED: actin filam ( 814) 3425 416.5 2.2e-115
NP_001128119 (OMIM: 608252) actin filament-associa ( 814) 3425 416.5 2.2e-115
NP_001309991 (OMIM: 614410) actin filament-associa ( 735) 1581 199.4 4.5e-50
XP_011535860 (OMIM: 614410) PREDICTED: actin filam ( 628) 1460 185.1 7.7e-46
XP_016864525 (OMIM: 614410) PREDICTED: actin filam ( 734) 1460 185.1 8.7e-46
NP_689619 (OMIM: 614410) actin filament-associated ( 768) 1460 185.1   9e-46
NP_001139809 (OMIM: 614410) actin filament-associa ( 725) 1459 185.0 9.3e-46
XP_016872317 (OMIM: 612420) PREDICTED: actin filam ( 731)  919 121.4 1.3e-26
XP_016872316 (OMIM: 612420) PREDICTED: actin filam ( 735)  897 118.8 7.8e-26
XP_016872319 (OMIM: 612420) PREDICTED: actin filam ( 679)  890 118.0 1.3e-25
XP_016872313 (OMIM: 612420) PREDICTED: actin filam ( 759)  821 109.9 3.9e-23
XP_016872311 (OMIM: 612420) PREDICTED: actin filam ( 785)  821 109.9   4e-23
XP_016872307 (OMIM: 612420) PREDICTED: actin filam ( 803)  808 108.4 1.2e-22
XP_016872304 (OMIM: 612420) PREDICTED: actin filam ( 829)  808 108.4 1.2e-22
XP_016872312 (OMIM: 612420) PREDICTED: actin filam ( 763)  799 107.3 2.4e-22
XP_016872308 (OMIM: 612420) PREDICTED: actin filam ( 789)  799 107.3 2.4e-22
NP_001309992 (OMIM: 614410) actin filament-associa ( 377)  715 97.2 1.3e-19
XP_016872306 (OMIM: 612420) PREDICTED: actin filam ( 813)  667 91.8 1.2e-17
NP_115939 (OMIM: 612420) actin filament-associated ( 814)  667 91.8 1.2e-17
XP_016872305 (OMIM: 612420) PREDICTED: actin filam ( 817)  667 91.8 1.2e-17
NP_001001936 (OMIM: 612420) actin filament-associa ( 818)  667 91.8 1.2e-17
XP_016872302 (OMIM: 612420) PREDICTED: actin filam ( 831)  667 91.8 1.2e-17
XP_016872301 (OMIM: 612420) PREDICTED: actin filam ( 832)  667 91.8 1.2e-17
XP_016872300 (OMIM: 612420) PREDICTED: actin filam ( 835)  667 91.8 1.2e-17
XP_016872299 (OMIM: 612420) PREDICTED: actin filam ( 836)  667 91.8 1.2e-17
XP_011538592 (OMIM: 612420) PREDICTED: actin filam ( 840)  667 91.8 1.2e-17
XP_016872296 (OMIM: 612420) PREDICTED: actin filam ( 843)  667 91.8 1.2e-17
XP_011538591 (OMIM: 612420) PREDICTED: actin filam ( 844)  667 91.8 1.2e-17
XP_016872293 (OMIM: 612420) PREDICTED: actin filam ( 854)  667 91.8 1.2e-17
XP_005270294 (OMIM: 612420) PREDICTED: actin filam ( 858)  667 91.8 1.2e-17
XP_005270290 (OMIM: 612420) PREDICTED: actin filam ( 876)  667 91.8 1.3e-17
XP_011538588 (OMIM: 612420) PREDICTED: actin filam ( 884)  667 91.8 1.3e-17
XP_016872315 (OMIM: 612420) PREDICTED: actin filam ( 757)  660 90.9   2e-17
XP_016872314 (OMIM: 612420) PREDICTED: actin filam ( 758)  660 90.9   2e-17
XP_005270298 (OMIM: 612420) PREDICTED: actin filam ( 802)  660 91.0 2.1e-17
NP_001274753 (OMIM: 612420) actin filament-associa ( 871)  611 85.2 1.2e-15
XP_016872321 (OMIM: 612420) PREDICTED: actin filam ( 795)  578 81.3 1.7e-14
XP_016872310 (OMIM: 612420) PREDICTED: actin filam ( 785)  569 80.2 3.4e-14
XP_016872309 (OMIM: 612420) PREDICTED: actin filam ( 786)  569 80.2 3.4e-14
XP_016872303 (OMIM: 612420) PREDICTED: actin filam ( 830)  569 80.3 3.6e-14
XP_016872298 (OMIM: 612420) PREDICTED: actin filam ( 841)  569 80.3 3.6e-14
XP_016872297 (OMIM: 612420) PREDICTED: actin filam ( 842)  569 80.3 3.6e-14
XP_016872295 (OMIM: 612420) PREDICTED: actin filam ( 845)  569 80.3 3.6e-14
XP_016872294 (OMIM: 612420) PREDICTED: actin filam ( 846)  569 80.3 3.6e-14
XP_016872292 (OMIM: 612420) PREDICTED: actin filam ( 867)  569 80.3 3.7e-14
XP_016872291 (OMIM: 612420) PREDICTED: actin filam ( 868)  569 80.3 3.7e-14


>>NP_940997 (OMIM: 608252) actin filament-associated pro  (730 aa)
 initn: 4815 init1: 4815 opt: 4815  Z-score: 3077.7  bits: 580.1 E(85289): 1.1e-164
Smith-Waterman score: 4815; 99.9% identity (100.0% similar) in 730 aa overlap (1-730:1-730)

               10        20        30        40        50        60
pF1KE1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE1 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE1 NPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPMASNGVTGKGKTLSSQPKKADPA
       :::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::
NP_940 NPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPVASNGVTGKGKTLSSQPKKADPA
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE1 AVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 AVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIE
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE1 VNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 VNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPK
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE1 SGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAPGSSPCRGHVLRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 SGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAPGSSPCRGHVLRK
              670       680       690       700       710       720

              730
pF1KE1 AKEWELKNGT
       ::::::::::
NP_940 AKEWELKNGT
              730

>>XP_006713972 (OMIM: 608252) PREDICTED: actin filament-  (751 aa)
 initn: 4815 init1: 4815 opt: 4815  Z-score: 3077.5  bits: 580.1 E(85289): 1.1e-164
Smith-Waterman score: 4815; 99.9% identity (100.0% similar) in 730 aa overlap (1-730:22-751)

                                    10        20        30         
pF1KE1                      MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQ
                            :::::::::::::::::::::::::::::::::::::::
XP_006 MRFKQEHPHPRNEAKAVTVRAMEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQ
               10        20        30        40        50        60

      40        50        60        70        80        90         
pF1KE1 SSKGFDVKDHAQKQETANSLPAPPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSKGFDVKDHAQKQETANSLPAPPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVP
               70        80        90       100       110       120

     100       110       120       130       140       150         
pF1KE1 LSPGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSPGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAF
              130       140       150       160       170       180

     160       170       180       190       200       210         
pF1KE1 LLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKI
              190       200       210       220       230       240

     220       230       240       250       260       270         
pF1KE1 TQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSE
              250       260       270       280       290       300

     280       290       300       310       320       330         
pF1KE1 RPSSDGEGVVENGITTCNGKEQVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RPSSDGEGVVENGITTCNGKEQVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE
              310       320       330       340       350       360

     340       350       360       370       380       390         
pF1KE1 QTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIP
              370       380       390       400       410       420

     400       410       420       430       440       450         
pF1KE1 GLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMS
              430       440       450       460       470       480

     460       470       480       490       500       510         
pF1KE1 ASVIQTAKQTFCFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_006 ASVIQTAKQTFCFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPVA
              490       500       510       520       530       540

     520       530       540       550       560       570         
pF1KE1 SNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKE
              550       560       570       580       590       600

     580       590       600       610       620       630         
pF1KE1 ALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEV
              610       620       630       640       650       660

     640       650       660       670       680       690         
pF1KE1 KESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA
              670       680       690       700       710       720

     700       710       720       730
pF1KE1 VLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
       :::::::::::::::::::::::::::::::
XP_006 VLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
              730       740       750 

>>XP_016864024 (OMIM: 608252) PREDICTED: actin filament-  (748 aa)
 initn: 4801 init1: 3423 opt: 3457  Z-score: 2213.5  bits: 420.2 E(85289): 1.5e-116
Smith-Waterman score: 4769; 97.5% identity (97.6% similar) in 748 aa overlap (1-730:1-748)

               10        20        30        40        50        60
pF1KE1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE1 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
              430       440       450       460       470       480

              490       500       510                         520  
pF1KE1 NPYLGGTSNGYAHPSGTALHYDDVPCINGS------------------LKGKKPPMASNG
       ::::::::::::::::::::::::::::::                  :::::::.::::
XP_016 NPYLGGTSNGYAHPSGTALHYDDVPCINGSWEPEDGFPASCSRGLGEELKGKKPPVASNG
              490       500       510       520       530       540

            530       540       550       560       570       580  
pF1KE1 VTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALR
              550       560       570       580       590       600

            590       600       610       620       630       640  
pF1KE1 NRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKES
              610       620       630       640       650       660

            650       660       670       680       690       700  
pF1KE1 LKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLK
              670       680       690       700       710       720

            710       720       730
pF1KE1 KSQAAPGSSPCRGHVLRKAKEWELKNGT
       ::::::::::::::::::::::::::::
XP_016 KSQAAPGSSPCRGHVLRKAKEWELKNGT
              730       740        

>>XP_016864025 (OMIM: 608252) PREDICTED: actin filament-  (555 aa)
 initn: 3423 init1: 3423 opt: 3425  Z-score: 2195.0  bits: 416.3 E(85289): 1.6e-115
Smith-Waterman score: 3425; 97.7% identity (98.3% similar) in 525 aa overlap (1-523:1-525)

               10        20        30        40        50        60
pF1KE1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE1 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
              430       440       450       460       470       480

              490       500       510         520       530        
pF1KE1 NPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKK--PPMASNGVTGKGKTLSSQPKKAD
       :::::::::::::::::::::::::::::: . .   :   : :.               
XP_016 NPYLGGTSNGYAHPSGTALHYDDVPCINGSWEPEDGFPASCSRGLGEEVLYDNAGLSRVK
              490       500       510       520       530       540

      540       550       560       570       580       590        
pF1KE1 PAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAA
                                                                   
XP_016 SPPWRLMGSQEKGRL                                             
              550                                                  

>>XP_011511846 (OMIM: 608252) PREDICTED: actin filament-  (814 aa)
 initn: 3423 init1: 3423 opt: 3425  Z-score: 2192.6  bits: 416.5 E(85289): 2.2e-115
Smith-Waterman score: 4285; 88.8% identity (89.0% similar) in 762 aa overlap (1-678:1-762)

               10        20        30        40        50        60
pF1KE1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE1 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
              430       440       450       460       470       480

              490       500       510                              
pF1KE1 NPYLGGTSNGYAHPSGTALHYDDVPCINGS------------------------------
       ::::::::::::::::::::::::::::::                              
XP_011 NPYLGGTSNGYAHPSGTALHYDDVPCINGSWEPEDGFPASCSRGLGEEVLYDNAGLYDNL
              490       500       510       520       530       540

                                                                   
pF1KE1 ------------------------------------------------------LKGKKP
                                                             ::::::
XP_011 PPPHIFARYSPADRKASRLSADKLSSNHYKYPASAQSVTNTSSVGRASLGLNSQLKGKKP
              550       560       570       580       590       600

        520       530       540       550       560       570      
pF1KE1 PMASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLK
       :.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLK
              610       620       630       640       650       660

        580       590       600       610       620       630      
pF1KE1 RKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELEL
              670       680       690       700       710       720

        640       650       660       670       680       690      
pF1KE1 TEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVN
       ::::::::::::::::::::::::::::::::::::::::::                  
XP_011 TEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVN
              730       740       750       760       770       780

        700       710       720       730
pF1KE1 SAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
                                         
XP_011 SAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
              790       800       810    

>--
 initn: 352 init1: 352 opt: 352  Z-score: 237.5  bits: 54.7 E(85289): 1.7e-06
Smith-Waterman score: 352; 100.0% identity (100.0% similar) in 52 aa overlap (679-730:763-814)

      650       660       670       680       690       700        
pF1KE1 GGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAP
                                     ::::::::::::::::::::::::::::::
XP_011 GGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAP
            740       750       760       770       780       790  

      710       720       730
pF1KE1 GSSPCRGHVLRKAKEWELKNGT
       ::::::::::::::::::::::
XP_011 GSSPCRGHVLRKAKEWELKNGT
            800       810    

>>NP_001128119 (OMIM: 608252) actin filament-associated   (814 aa)
 initn: 3423 init1: 3423 opt: 3425  Z-score: 2192.6  bits: 416.5 E(85289): 2.2e-115
Smith-Waterman score: 4285; 88.8% identity (89.0% similar) in 762 aa overlap (1-678:1-762)

               10        20        30        40        50        60
pF1KE1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE1 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
              430       440       450       460       470       480

              490       500       510                              
pF1KE1 NPYLGGTSNGYAHPSGTALHYDDVPCINGS------------------------------
       ::::::::::::::::::::::::::::::                              
NP_001 NPYLGGTSNGYAHPSGTALHYDDVPCINGSWEPEDGFPASCSRGLGEEVLYDNAGLYDNL
              490       500       510       520       530       540

                                                                   
pF1KE1 ------------------------------------------------------LKGKKP
                                                             ::::::
NP_001 PPPHIFARYSPADRKASRLSADKLSSNHYKYPASAQSVTNTSSVGRASLGLNSQLKGKKP
              550       560       570       580       590       600

        520       530       540       550       560       570      
pF1KE1 PMASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLK
       :.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLK
              610       620       630       640       650       660

        580       590       600       610       620       630      
pF1KE1 RKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELEL
              670       680       690       700       710       720

        640       650       660       670       680       690      
pF1KE1 TEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVN
       ::::::::::::::::::::::::::::::::::::::::::                  
NP_001 TEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVN
              730       740       750       760       770       780

        700       710       720       730
pF1KE1 SAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
                                         
NP_001 SAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
              790       800       810    

>--
 initn: 352 init1: 352 opt: 352  Z-score: 237.5  bits: 54.7 E(85289): 1.7e-06
Smith-Waterman score: 352; 100.0% identity (100.0% similar) in 52 aa overlap (679-730:763-814)

      650       660       670       680       690       700        
pF1KE1 GGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAP
                                     ::::::::::::::::::::::::::::::
NP_001 GGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAP
            740       750       760       770       780       790  

      710       720       730
pF1KE1 GSSPCRGHVLRKAKEWELKNGT
       ::::::::::::::::::::::
NP_001 GSSPCRGHVLRKAKEWELKNGT
            800       810    

>>NP_001309991 (OMIM: 614410) actin filament-associated   (735 aa)
 initn: 1801 init1: 680 opt: 1581  Z-score: 1020.0  bits: 199.4 E(85289): 4.5e-50
Smith-Waterman score: 2075; 46.5% identity (71.7% similar) in 766 aa overlap (1-727:7-733)

                     10        20        30        40        50    
pF1KE1       MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQE
             .:.:. ::  .: :::::::..:. ::: ....::   :: . . .:. .    
NP_001 MDRGQVLEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASIL---QSLQPLPAKEVSYLYV
               10        20        30        40           50       

           60                     70        80                     
pF1KE1 TANSLPAPPQM-------------PLPEIPQPWLPPDSG-----------------PPPL
       .. .: . :..              : ..:.    :..:                 ::::
NP_001 NTADLHSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPL
        60        70        80        90       100       110       

           90       100       110        120       130       140   
pF1KE1 PTSSLPEGYYEEAVPLSPGKAPEYITS-NYDSDAMSSSYESYDEEEEDGKGKKTRHQWPS
       :..  :: :::::.::.:::.::::.: : :::::::::::::::::.::. . ::::::
NP_001 PNKPPPEDYYEEALPLGPGKSPEYISSHNNDSDAMSSSYESYDEEEEEGKSPQPRHQWPS
       120       130       140       150       160       170       

           150       160       170       180       190       200   
pF1KE1 EEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNI
       ::::: ::.. .::::::::::::::.: : ::.. .:::::::::.::...: :. :.:
NP_001 EEASMHLVRECRICAFLLRKKRFGQWAKQLTVIREDQLLCYKSSKDRQPHLRLALDTCSI
       180       190       200       210       220       230       

           210       220       230       240       250       260   
pF1KE1 TYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGPVDSECPPPP
        :.::::..:.:::..:: .:. ::::.::.::::.:::::.:. .  .:    : :  :
NP_001 IYVPKDSRHKRHELRFTQGATEVLVLALQSREQAEEWLKVIREVSKPVGGAEGVEVPRSP
       240       250       260       270       280       290       

           270       280        290       300          310         
pF1KE1 SSPVHKAELEKKLSSERPSSDGEGV-VENGITTCNGKEQV---KRKKSSKSEAKGTVSKV
          . : .:.:.::.:. .::...: : .. .: . .:     : :::: .: ::..:..
NP_001 VL-LCKLDLDKRLSQEKQTSDSDSVGVGDNCSTLGRRETCDHGKGKKSSLAELKGSMSRA
        300       310       320       330       340       350      

     320       330        340       350       360       370        
pF1KE1 TGKKITKIISLGKKKPSTDE-QTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDNKLIFHK
       .:.:::.::...:::  .:. ::::.::.:: ::::::: :. :.:::::.: : : :::
NP_001 AGRKITRIIGFSKKKTLADDLQTSSTEEEVPCCGYLNVLVNQGWKERWCRLKCNTLYFHK
        360       370       380       390       400       410      

      380       390       400       410       420       430        
pF1KE1 DRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLA
       :. ::.::. .: :.:::: ::.  .::..::.::: ::::.:::: :::::::.:.::.
NP_001 DHMDLRTHVNAIALQGCEVAPGFGPRHPFAFRILRNRQEVAILEASCSEDMGRWLGLLLV
        420       430       440       450       460       470      

      440       450       460       470       480       490        
pF1KE1 ETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISANPYLGGTSNGYAHPSGTA
       : :: . ::::::::.:::  .:........:            :  . .: . .:    
NP_001 EMGSRVTPEALHYDYVDVETLTSIVSAGRNSFL-----------YARSCQNQWPEPR---
        480       490       500                  510       520     

      500       510       520        530       540       550       
pF1KE1 LHYDDVPCINGSLKGKKPPMASNG-VTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGK
         :::::    ... ..:   ... :  .... : . ...:: . ::: .:.: ::::::
NP_001 -VYDDVP--YEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGK
               530       540       550       560       570         

       560       570       580       590       600       610       
pF1KE1 NRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQ
       ::.: ::.:  ...:.: :.::..:..:  ::.:...:. ::. . : : .: ::: .  
NP_001 NRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKA-LEEAVAT
     580       590       600       610       620       630         

       620       630       640       650         660       670     
pF1KE1 LEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAI--EPKSGTSSPQSPVFRHRT
       :: .:: :: .:..:::.:. ::: :...:::: .:::..  .:::: ..          
NP_001 LEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGLSVSSKPKSGETA----------
      640       650       660       670       680                  

         680       690       700       710       720       730
pF1KE1 LENSPISSCDTSDTEGPVPVNSAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
         :.: .:      : :.::: .. :.: . .  .:  .:.::.::::::.:   
NP_001 --NKPQNSVP----EQPLPVNCVSELRKRSPSIVASN-QGRVLQKAKEWEMKKT 
        690           700       710        720       730      

>>XP_011535860 (OMIM: 614410) PREDICTED: actin filament-  (628 aa)
 initn: 1699 init1: 679 opt: 1460  Z-score: 944.0  bits: 185.1 E(85289): 7.7e-46
Smith-Waterman score: 1904; 48.4% identity (73.8% similar) in 653 aa overlap (85-727:10-626)

           60        70        80        90       100         110  
pF1KE1 TANSLPAPPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGK--APEYITSN
                                     :. :. .::::.:    :.     :  .: 
XP_011                      MVLGSDGCSPSHSIVDGYYEDADSSYPATRVNGELKSSY
                                    10        20        30         

            120       130       140       150       160       170  
pF1KE1 YDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKL
        :::::::::::::::::.::. . ::::::::::: ::.. .::::::::::::::.: 
XP_011 NDSDAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQ
      40        50        60        70        80        90         

            180       190       200       210       220       230  
pF1KE1 LCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQ
       : ::.. .:::::::::.::...: :. :.: :.::::..:.:::..:: .:. ::::.:
XP_011 LTVIREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQ
     100       110       120       130       140       150         

            240       250       260       270       280        290 
pF1KE1 SKEQAEQWLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGV-VEN
       :.::::.:::::.:. .  .:    : :  :   . : .:.:.::.:. .::...: : .
XP_011 SREQAEEWLKVIREVSKPVGGAEGVEVPRSPVL-LCKLDLDKRLSQEKQTSDSDSVGVGD
     160       170       180       190        200       210        

             300          310       320       330        340       
pF1KE1 GITTCNGKEQV---KRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE-QTSSAEED
       . .: . .:     : :::: .: ::..:...:.:::.::...:::  .:. ::::.::.
XP_011 NCSTLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEE
      220       230       240       250       260       270        

       350       360       370       380       390       400       
pF1KE1 VPTCGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPL
       :: ::::::: :. :.:::::.: : : ::::. ::.::. .: :.:::: ::.  .::.
XP_011 VPCCGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPF
      280       290       300       310       320       330        

       410       420       430       440       450       460       
pF1KE1 TFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAK
       .::.::: ::::.:::: :::::::.:.::.: :: . ::::::::.:::  .:......
XP_011 AFRILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGR
      340       350       360       370       380       390        

       470       480       490       500       510       520       
pF1KE1 QTFCFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPMASNG-VTGK
       ..:            :  . .: . .:      :::::    ... ..:   ... :  .
XP_011 NSFL-----------YARSCQNQWPEPRV----YDDVP--YEKMQDEEPERPTGAQVKRH
      400                  410           420         430       440 

        530       540       550       560       570       580      
pF1KE1 GKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLA
       ... : . ...:: . ::: .:.: ::::::::.: ::.:  ...:.: :.::..:..: 
XP_011 ASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELI
             450       460       470       480       490       500 

        590       600       610       620       630       640      
pF1KE1 QLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKA
        ::.:...:. ::. . : : .: ::: .  :: .:: :: .:..:::.:. ::: :...
XP_011 ALRQEKRELKEAIRSSPGAKLKA-LEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQS
             510       520        530       540       550       560

        650         660       670       680       690       700    
pF1KE1 LAGGVTLGLAI--EPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKS
       :::: .:::..  .:::: ..            :.: .:      : :.::: .. :.: 
XP_011 LAGGPALGLSVSSKPKSGETA------------NKPQNSVP----EQPLPVNCVSELRKR
              570       580                       590       600    

          710       720       730
pF1KE1 QAAPGSSPCRGHVLRKAKEWELKNGT
       . .  .:  .:.::.::::::.:   
XP_011 SPSIVASN-QGRVLQKAKEWEMKKT 
          610        620         

>>XP_016864525 (OMIM: 614410) PREDICTED: actin filament-  (734 aa)
 initn: 1699 init1: 679 opt: 1460  Z-score: 943.0  bits: 185.1 E(85289): 8.7e-46
Smith-Waterman score: 1953; 46.9% identity (71.0% similar) in 710 aa overlap (62-727:59-732)

              40        50        60        70         80          
pF1KE1 TNILLRIQSSKGFDVKDHAQKQETANSLPAPPQMPLPEIPQ-PWLPPDSG-PPPLPTSSL
                                     : .   ::. . : :   .  :::::..  
XP_016 HSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNKPP
       30        40        50        60        70        80        

      90       100       110                                       
pF1KE1 PEGYYEEAVPLSPGKAPEYITSNY----------------------------------DS
       :: :::::.::.:::.::::.:.                                   ::
XP_016 PEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYNDS
       90       100       110       120       130       140        

         120       130       140       150       160       170     
pF1KE1 DAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCV
       :::::::::::::::.::. . ::::::::::: ::.. .::::::::::::::.: : :
XP_016 DAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQLTV
      150       160       170       180       190       200        

         180       190       200       210       220       230     
pF1KE1 IKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKE
       :.. .:::::::::.::...: :. :.: :.::::..:.:::..:: .:. ::::.::.:
XP_016 IREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQSRE
      210       220       230       240       250       260        

         240       250       260       270       280        290    
pF1KE1 QAEQWLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGV-VENGIT
       :::.:::::.:. .  .:    : :  :   . : .:.:.::.:. .::...: : .. .
XP_016 QAEEWLKVIREVSKPVGGAEGVEVPRSPVL-LCKLDLDKRLSQEKQTSDSDSVGVGDNCS
      270       280       290        300       310       320       

          300          310       320       330        340       350
pF1KE1 TCNGKEQV---KRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE-QTSSAEEDVPT
       : . .:     : :::: .: ::..:...:.:::.::...:::  .:. ::::.::.:: 
XP_016 TLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVPC
       330       340       350       360       370       380       

              360       370       380       390       400       410
pF1KE1 CGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFR
       ::::::: :. :.:::::.: : : ::::. ::.::. .: :.:::: ::.  .::..::
XP_016 CGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAFR
       390       400       410       420       430       440       

              420       430       440       450       460       470
pF1KE1 LLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTF
       .::: ::::.:::: :::::::.:.::.: :: . ::::::::.:::  .:........:
XP_016 ILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNSF
       450       460       470       480       490       500       

              480       490       500       510       520          
pF1KE1 CFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPMASNG-VTGKGKT
                   :  . .: . .:      :::::    ... ..:   ... :  ....
XP_016 L-----------YARSCQNQWPEPRV----YDDVP--YEKMQDEEPERPTGAQVKRHASS
                  510       520             530       540       550

     530       540       550       560       570       580         
pF1KE1 LSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLR
        : . ...:: . ::: .:.: ::::::::.: ::.:  ...:.: :.::..:..:  ::
XP_016 CSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALR
              560       570       580       590       600       610

     590       600       610       620       630       640         
pF1KE1 KERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAG
       .:...:. ::. . : : .: ::: .  :: .:: :: .:..:::.:. ::: :...:::
XP_016 QEKRELKEAIRSSPGAKLKA-LEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAG
              620       630        640       650       660         

     650         660       670       680       690       700       
pF1KE1 GVTLGLAI--EPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAA
       : .:::..  .:::: ..            :.: .:      : :.::: .. :.: . .
XP_016 GPALGLSVSSKPKSGETA------------NKPQNSVP----EQPLPVNCVSELRKRSPS
     670       680                   690           700       710   

       710       720       730
pF1KE1 PGSSPCRGHVLRKAKEWELKNGT
         .:  .:.::.::::::.:   
XP_016 IVASN-QGRVLQKAKEWEMKKT 
            720       730     

>>NP_689619 (OMIM: 614410) actin filament-associated pro  (768 aa)
 initn: 1785 init1: 679 opt: 1460  Z-score: 942.8  bits: 185.1 E(85289): 9e-46
Smith-Waterman score: 1953; 46.9% identity (71.0% similar) in 710 aa overlap (62-727:93-766)

              40        50        60        70         80          
pF1KE1 TNILLRIQSSKGFDVKDHAQKQETANSLPAPPQMPLPEIPQ-PWLPPDSG-PPPLPTSSL
                                     : .   ::. . : :   .  :::::..  
NP_689 HSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNKPP
             70        80        90       100       110       120  

      90       100       110                                       
pF1KE1 PEGYYEEAVPLSPGKAPEYITSNY----------------------------------DS
       :: :::::.::.:::.::::.:.                                   ::
NP_689 PEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYNDS
            130       140       150       160       170       180  

         120       130       140       150       160       170     
pF1KE1 DAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCV
       :::::::::::::::.::. . ::::::::::: ::.. .::::::::::::::.: : :
NP_689 DAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQLTV
            190       200       210       220       230       240  

         180       190       200       210       220       230     
pF1KE1 IKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKE
       :.. .:::::::::.::...: :. :.: :.::::..:.:::..:: .:. ::::.::.:
NP_689 IREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQSRE
            250       260       270       280       290       300  

         240       250       260       270       280        290    
pF1KE1 QAEQWLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGV-VENGIT
       :::.:::::.:. .  .:    : :  :   . : .:.:.::.:. .::...: : .. .
NP_689 QAEEWLKVIREVSKPVGGAEGVEVPRSPVL-LCKLDLDKRLSQEKQTSDSDSVGVGDNCS
            310       320       330        340       350       360 

          300          310       320       330        340       350
pF1KE1 TCNGKEQV---KRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE-QTSSAEEDVPT
       : . .:     : :::: .: ::..:...:.:::.::...:::  .:. ::::.::.:: 
NP_689 TLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVPC
             370       380       390       400       410       420 

              360       370       380       390       400       410
pF1KE1 CGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFR
       ::::::: :. :.:::::.: : : ::::. ::.::. .: :.:::: ::.  .::..::
NP_689 CGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAFR
             430       440       450       460       470       480 

              420       430       440       450       460       470
pF1KE1 LLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTF
       .::: ::::.:::: :::::::.:.::.: :: . ::::::::.:::  .:........:
NP_689 ILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNSF
             490       500       510       520       530       540 

              480       490       500       510       520          
pF1KE1 CFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPMASNG-VTGKGKT
                   :  . .: . .:      :::::    ... ..:   ... :  ....
NP_689 L-----------YARSCQNQWPEPRV----YDDVP--YEKMQDEEPERPTGAQVKRHASS
                        550           560         570       580    

     530       540       550       560       570       580         
pF1KE1 LSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLR
        : . ...:: . ::: .:.: ::::::::.: ::.:  ...:.: :.::..:..:  ::
NP_689 CSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALR
          590       600       610       620       630       640    

     590       600       610       620       630       640         
pF1KE1 KERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAG
       .:...:. ::. . : : .: ::: .  :: .:: :: .:..:::.:. ::: :...:::
NP_689 QEKRELKEAIRSSPGAKLKA-LEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAG
          650       660        670       680       690       700   

     650         660       670       680       690       700       
pF1KE1 GVTLGLAI--EPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAA
       : .:::..  .:::: ..            :.: .:      : :.::: .. :.: . .
NP_689 GPALGLSVSSKPKSGETA------------NKPQNSVP----EQPLPVNCVSELRKRSPS
           710       720                       730       740       

       710       720       730
pF1KE1 PGSSPCRGHVLRKAKEWELKNGT
         .:  .:.::.::::::.:   
NP_689 IVASN-QGRVLQKAKEWEMKKT 
       750        760         




730 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 07:25:58 2016 done: Sat Nov  5 07:26:00 2016
 Total Scan time: 11.840 Total Display time:  0.180

Function used was FASTA [36.3.4 Apr, 2011]
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