Result of FASTA (omim) for pF1KE9543
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE9543, 496 aa
  1>>>pF1KE9543     496 - 496 aa - 496 aa
Library: /omim/omim.rfq.tfa
  64369986 residues in 92320 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.0390+/-0.000428; mu= 19.3222+/- 0.026
 mean_var=68.6856+/-14.472, 0's: 0 Z-trim(110.9): 310  B-trim: 1458 in 2/51
 Lambda= 0.154754
 statistics sampled from 19806 (20145) to 19806 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.582), E-opt: 0.2 (0.218), width:  16
 Scan time:  4.540

The best scores are:                                      opt bits E(92320)
NP_001186564 (OMIM: 102981) pituitary adenylate cy ( 496) 3427 774.8       0
NP_001186565 (OMIM: 102981) pituitary adenylate cy ( 495) 3410 771.0       0
XP_016867225 (OMIM: 102981) pituitary adenylate cy ( 489) 3356 758.9       0
XP_006715708 (OMIM: 102981) pituitary adenylate cy ( 496) 3214 727.2 2.8e-209
XP_016867227 (OMIM: 102981) pituitary adenylate cy ( 439) 2671 605.9 7.9e-173
XP_016867226 (OMIM: 102981) pituitary adenylate cy ( 475) 2660 603.5 4.6e-172
NP_001109 (OMIM: 102981) pituitary adenylate cycla ( 468) 2443 555.1 1.8e-157
XP_005249675 (OMIM: 102981) pituitary adenylate cy ( 411) 1687 386.2  1e-106
NP_001186566 (OMIM: 102981) pituitary adenylate cy ( 447) 1676 383.8  6e-106
XP_024302684 (OMIM: 601970) vasoactive intestinal  ( 438)  989 230.4 8.8e-60
XP_024302683 (OMIM: 601970) vasoactive intestinal  ( 463)  989 230.4 9.1e-60
XP_024302682 (OMIM: 601970) vasoactive intestinal  ( 463)  989 230.4 9.1e-60
NP_003373 (OMIM: 601970) vasoactive intestinal pol ( 438)  987 230.0 1.2e-59
XP_006716170 (OMIM: 601970) vasoactive intestinal  ( 455)  987 230.0 1.2e-59
XP_005249618 (OMIM: 601970) vasoactive intestinal  ( 463)  987 230.0 1.2e-59
XP_024302685 (OMIM: 601970) vasoactive intestinal  ( 375)  984 229.2 1.7e-59
XP_006716171 (OMIM: 601970) vasoactive intestinal  ( 392)  984 229.3 1.7e-59
NP_001238813 (OMIM: 192321) vasoactive intestinal  ( 409)  927 216.5 1.2e-55
XP_005265494 (OMIM: 192321) vasoactive intestinal  ( 456)  927 216.6 1.3e-55
XP_011532382 (OMIM: 192321) vasoactive intestinal  ( 351)  916 214.0 5.9e-55
XP_005265496 (OMIM: 192321) vasoactive intestinal  ( 410)  916 214.1 6.7e-55
XP_011532381 (OMIM: 192321) vasoactive intestinal  ( 416)  916 214.1 6.8e-55
XP_005265495 (OMIM: 192321) vasoactive intestinal  ( 416)  916 214.1 6.8e-55
NP_001238811 (OMIM: 192321) vasoactive intestinal  ( 416)  916 214.1 6.8e-55
NP_001238814 (OMIM: 192321) vasoactive intestinal  ( 430)  916 214.1   7e-55
XP_024308806 (OMIM: 182098) secretin receptor isof ( 372)  915 213.8 7.3e-55
NP_004615 (OMIM: 192321) vasoactive intestinal pol ( 457)  916 214.1 7.3e-55
NP_002971 (OMIM: 182098) secretin receptor precurs ( 440)  915 213.9 8.3e-55
XP_016860160 (OMIM: 182098) secretin receptor isof ( 409)  900 210.5   8e-54
XP_016860161 (OMIM: 182098) secretin receptor isof ( 377)  895 209.4 1.6e-53
XP_016860159 (OMIM: 182098) secretin receptor isof ( 435)  895 209.4 1.8e-53
XP_011509923 (OMIM: 182098) secretin receptor isof ( 445)  895 209.4 1.8e-53
NP_001295188 (OMIM: 601970) vasoactive intestinal  ( 422)  849 199.1 2.2e-50
XP_011514852 (OMIM: 601970) vasoactive intestinal  ( 439)  849 199.2 2.3e-50
XP_024302686 (OMIM: 601970) vasoactive intestinal  ( 300)  775 182.5 1.6e-45
XP_016868069 (OMIM: 601970) vasoactive intestinal  ( 300)  775 182.5 1.6e-45
NP_000814 (OMIM: 139191,618157) growth hormone-rel ( 423)  756 178.4 3.9e-44
XP_005263787 (OMIM: 182098) secretin receptor isof ( 262)  616 147.0 6.9e-35
NP_001295347 (OMIM: 137241) gastric inhibitory pol ( 430)  611 146.0 2.2e-34
NP_000155 (OMIM: 137241) gastric inhibitory polype ( 466)  611 146.0 2.3e-34
XP_016860162 (OMIM: 182098) secretin receptor isof ( 267)  596 142.5 1.5e-33
NP_001291451 (OMIM: 601970) vasoactive intestinal  ( 358)  556 133.7 9.5e-31
XP_011525013 (OMIM: 137241) gastric inhibitory pol ( 472)  554 133.3 1.6e-30
XP_011525012 (OMIM: 137241) gastric inhibitory pol ( 508)  554 133.3 1.7e-30
XP_011525011 (OMIM: 137241) gastric inhibitory pol ( 508)  554 133.3 1.7e-30
XP_011525016 (OMIM: 137241) gastric inhibitory pol ( 369)  516 124.8 4.7e-28
XP_011525017 (OMIM: 137241) gastric inhibitory pol ( 369)  516 124.8 4.7e-28
NP_001238812 (OMIM: 192321) vasoactive intestinal  ( 247)  454 110.8 5.1e-24
NP_001733 (OMIM: 114131,166710) calcitonin recepto ( 474)  445 109.0 3.4e-23
NP_001158210 (OMIM: 114131,166710) calcitonin rece ( 474)  445 109.0 3.4e-23


>>NP_001186564 (OMIM: 102981) pituitary adenylate cyclas  (496 aa)
 initn: 3427 init1: 3427 opt: 3427  Z-score: 4135.9  bits: 774.8 E(92320):    0
Smith-Waterman score: 3427; 100.0% identity (100.0% similar) in 496 aa overlap (1-496:1-496)

               10        20        30        40        50        60
pF1KE9 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE9 ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE9 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE9 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE9 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE9 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE9 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE9 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
              430       440       450       460       470       480

              490      
pF1KE9 SSQIRMSGLPADNLAT
       ::::::::::::::::
NP_001 SSQIRMSGLPADNLAT
              490      

>>NP_001186565 (OMIM: 102981) pituitary adenylate cyclas  (495 aa)
 initn: 2450 init1: 2450 opt: 3410  Z-score: 4115.4  bits: 771.0 E(92320):    0
Smith-Waterman score: 3410; 99.8% identity (99.8% similar) in 496 aa overlap (1-496:1-495)

               10        20        30        40        50        60
pF1KE9 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE9 ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE9 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE9 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE9 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE9 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
NP_001 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYF-CVQKCYCKPQ
              310       320       330       340        350         

              370       380       390       400       410       420
pF1KE9 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
     360       370       380       390       400       410         

              430       440       450       460       470       480
pF1KE9 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
     420       430       440       450       460       470         

              490      
pF1KE9 SSQIRMSGLPADNLAT
       ::::::::::::::::
NP_001 SSQIRMSGLPADNLAT
     480       490     

>>XP_016867225 (OMIM: 102981) pituitary adenylate cyclas  (489 aa)
 initn: 3366 init1: 2750 opt: 3356  Z-score: 4050.3  bits: 758.9 E(92320):    0
Smith-Waterman score: 3356; 98.6% identity (98.6% similar) in 496 aa overlap (1-496:1-489)

               10        20        30        40        50        60
pF1KE9 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE9 ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
       ::::::::::::::::::::::::::::       :::::::::::::::::::::::::
XP_016 ITCWKPAHVGEMVLVSCPELFRIFNPDQ-------GESDFGDSNSLDLSDMGVVSRNCTE
               70        80               90       100       110   

              130       140       150       160       170       180
pF1KE9 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
           120       130       140       150       160       170   

              190       200       210       220       230       240
pF1KE9 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
           180       190       200       210       220       230   

              250       260       270       280       290       300
pF1KE9 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
           240       250       260       270       280       290   

              310       320       330       340       350       360
pF1KE9 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQ
           300       310       320       330       340       350   

              370       380       390       400       410       420
pF1KE9 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
           360       370       380       390       400       410   

              430       440       450       460       470       480
pF1KE9 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
           420       430       440       450       460       470   

              490      
pF1KE9 SSQIRMSGLPADNLAT
       ::::::::::::::::
XP_016 SSQIRMSGLPADNLAT
           480         

>>XP_006715708 (OMIM: 102981) pituitary adenylate cyclas  (496 aa)
 initn: 3214 init1: 3214 opt: 3214  Z-score: 3878.9  bits: 727.2 E(92320): 2.8e-209
Smith-Waterman score: 3214; 95.0% identity (96.4% similar) in 496 aa overlap (1-496:1-496)

               10        20        30        40        50        60
pF1KE9 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE9 ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE9 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE9 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE9 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE9 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::.. ..    :  
XP_006 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYLTNLSPRVPKKA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE9 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
       : .      .. :   ::::::::::::::::::::::::::::::::::::::::::::
XP_006 REDPLPVPSDQHSLPFLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE9 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
              430       440       450       460       470       480

              490      
pF1KE9 SSQIRMSGLPADNLAT
       ::::::::::::::::
XP_006 SSQIRMSGLPADNLAT
              490      

>>XP_016867227 (OMIM: 102981) pituitary adenylate cyclas  (439 aa)
 initn: 2664 init1: 2664 opt: 2671  Z-score: 3224.4  bits: 605.9 E(92320): 7.9e-173
Smith-Waterman score: 2880; 88.5% identity (88.5% similar) in 496 aa overlap (1-496:1-439)

               10        20        30        40        50        60
pF1KE9 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::        
XP_016 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSP--------
               10        20        30        40        50          

               70        80        90       100       110       120
pF1KE9 ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
                                                        :::::::::::
XP_016 -------------------------------------------------DMGVVSRNCTE
                                                              60   

              130       140       150       160       170       180
pF1KE9 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
            70        80        90       100       110       120   

              190       200       210       220       230       240
pF1KE9 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
           130       140       150       160       170       180   

              250       260       270       280       290       300
pF1KE9 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
           190       200       210       220       230       240   

              310       320       330       340       350       360
pF1KE9 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQ
           250       260       270       280       290       300   

              370       380       390       400       410       420
pF1KE9 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
           310       320       330       340       350       360   

              430       440       450       460       470       480
pF1KE9 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
           370       380       390       400       410       420   

              490      
pF1KE9 SSQIRMSGLPADNLAT
       ::::::::::::::::
XP_016 SSQIRMSGLPADNLAT
           430         

>>XP_016867226 (OMIM: 102981) pituitary adenylate cyclas  (475 aa)
 initn: 3275 init1: 2659 opt: 2660  Z-score: 3210.7  bits: 603.5 E(92320): 4.6e-172
Smith-Waterman score: 3237; 95.8% identity (95.8% similar) in 496 aa overlap (1-496:1-475)

               10        20        30        40        50        60
pF1KE9 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE9 ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
       ::::::::::::::::::::::::::::                     :::::::::::
XP_016 ITCWKPAHVGEMVLVSCPELFRIFNPDQ---------------------DMGVVSRNCTE
               70        80                             90         

              130       140       150       160       170       180
pF1KE9 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
     100       110       120       130       140       150         

              190       200       210       220       230       240
pF1KE9 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
     160       170       180       190       200       210         

              250       260       270       280       290       300
pF1KE9 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
     220       230       240       250       260       270         

              310       320       330       340       350       360
pF1KE9 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQ
     280       290       300       310       320       330         

              370       380       390       400       410       420
pF1KE9 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
     340       350       360       370       380       390         

              430       440       450       460       470       480
pF1KE9 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
     400       410       420       430       440       450         

              490      
pF1KE9 SSQIRMSGLPADNLAT
       ::::::::::::::::
XP_016 SSQIRMSGLPADNLAT
     460       470     

>>NP_001109 (OMIM: 102981) pituitary adenylate cyclase-a  (468 aa)
 initn: 2443 init1: 2443 opt: 2443  Z-score: 2948.9  bits: 555.1 E(92320): 1.8e-157
Smith-Waterman score: 3157; 94.4% identity (94.4% similar) in 496 aa overlap (1-496:1-468)

               10        20        30        40        50        60
pF1KE9 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE9 ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE9 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE9 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE9 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE9 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::            
NP_001 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIY------------
              310       320       330       340                    

              370       380       390       400       410       420
pF1KE9 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
                       ::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----------------LRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
                      350       360       370       380       390  

              430       440       450       460       470       480
pF1KE9 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
            400       410       420       430       440       450  

              490      
pF1KE9 SSQIRMSGLPADNLAT
       ::::::::::::::::
NP_001 SSQIRMSGLPADNLAT
            460        

>>XP_005249675 (OMIM: 102981) pituitary adenylate cyclas  (411 aa)
 initn: 1680 init1: 1680 opt: 1687  Z-score: 2037.5  bits: 386.2 E(92320): 1e-106
Smith-Waterman score: 2610; 82.9% identity (82.9% similar) in 496 aa overlap (1-496:1-411)

               10        20        30        40        50        60
pF1KE9 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::        
XP_005 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSP--------
               10        20        30        40        50          

               70        80        90       100       110       120
pF1KE9 ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
                                                        :::::::::::
XP_005 -------------------------------------------------DMGVVSRNCTE
                                                              60   

              130       140       150       160       170       180
pF1KE9 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
            70        80        90       100       110       120   

              190       200       210       220       230       240
pF1KE9 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
           130       140       150       160       170       180   

              250       260       270       280       290       300
pF1KE9 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
           190       200       210       220       230       240   

              310       320       330       340       350       360
pF1KE9 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::            
XP_005 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIY------------
           250       260       270       280       290             

              370       380       390       400       410       420
pF1KE9 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
                       ::::::::::::::::::::::::::::::::::::::::::::
XP_005 ----------------LRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
                             300       310       320       330     

              430       440       450       460       470       480
pF1KE9 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
         340       350       360       370       380       390     

              490      
pF1KE9 SSQIRMSGLPADNLAT
       ::::::::::::::::
XP_005 SSQIRMSGLPADNLAT
         400       410 

>>NP_001186566 (OMIM: 102981) pituitary adenylate cyclas  (447 aa)
 initn: 2291 init1: 1675 opt: 1676  Z-score: 2023.7  bits: 383.8 E(92320): 6e-106
Smith-Waterman score: 2967; 90.1% identity (90.1% similar) in 496 aa overlap (1-496:1-447)

               10        20        30        40        50        60
pF1KE9 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE9 ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
       ::::::::::::::::::::::::::::                     :::::::::::
NP_001 ITCWKPAHVGEMVLVSCPELFRIFNPDQ---------------------DMGVVSRNCTE
               70        80                             90         

              130       140       150       160       170       180
pF1KE9 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
     100       110       120       130       140       150         

              190       200       210       220       230       240
pF1KE9 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
     160       170       180       190       200       210         

              250       260       270       280       290       300
pF1KE9 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
     220       230       240       250       260       270         

              310       320       330       340       350       360
pF1KE9 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::            
NP_001 DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIY------------
     280       290       300       310       320                   

              370       380       390       400       410       420
pF1KE9 RAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
                       ::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----------------LRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQ
                       330       340       350       360       370 

              430       440       450       460       470       480
pF1KE9 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKS
             380       390       400       410       420       430 

              490      
pF1KE9 SSQIRMSGLPADNLAT
       ::::::::::::::::
NP_001 SSQIRMSGLPADNLAT
             440       

>>XP_024302684 (OMIM: 601970) vasoactive intestinal poly  (438 aa)
 initn: 1230 init1: 463 opt: 989  Z-score: 1194.9  bits: 230.4 E(92320): 8.8e-60
Smith-Waterman score: 1270; 49.1% identity (72.1% similar) in 405 aa overlap (82-482:56-429)

              60        70        80        90        100       110
pF1KE9 PGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETE-TIGESDFGDSNSLDLSD
                                     : : :..  : .   : : .  ...  .. 
XP_024 LPKSLQQFLQQSRYCPSVEFLSSSRVFASERPFFPSKKQEHHFPSGISCYPGGQGTAVAY
          30        40        50        60        70        80     

              120       130       140       150       160       170
pF1KE9 MGVVSRNCTEDGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTT
        : .:.::: ::::: :: . ::::... :.:.  .  .:. :::.::.:::.::..:.:
XP_024 WGNISKNCTSDGWSETFPDFVDACGYSDPEDES--KITFYILVKAIYTLGYSVSLMSLAT
          90       100       110         120       130       140   

              180       190       200       210       220          
pF1KE9 AMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCF---ISTVECK
       . .::: :::::::::.::.:::.::.::::::..:: .::. . . ::     : : ::
XP_024 GSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCK
           150       160       170       180       190       200   

       230       240       250       260       270       280       
pF1KE9 AVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATL
         .::..::...:.:::..::::: :::: ...: :: :  : .:::: ::::. .:.. 
XP_024 LSLVFLQYCIMANFFWLLVEGLYLHTLLV-AMLPPRRCFLAYLLIGWGLPTVCIGAWTAA
           210       220       230        240       250       260  

       290       300       310       320       330       340       
pF1KE9 RLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSI
       :::..:::::: :: .. ::::. :.. ::.:::::::.:: ::.::: :::.:::..: 
XP_024 RLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQ
            270       280       290       300       310       320  

       350       360       370       380       390       400       
pF1KE9 YFSCVQKCYCKPQRAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKR
       :                             :::.::::::::::.:: :::  : ..:..
XP_024 Y----------------------------KRLAKSTLLLIPLFGVHYMVFAVFPISISSK
                                        330       340       350    

       410       420       430       440       450       460       
pF1KE9 ERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSG
        ...::: ::::::.::::::::::.::: :.::::::   .   . :..    :.. .:
XP_024 YQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNG
          360       370       380       390       400       410    

       470       480       490      
pF1KE9 VNGGTQLSILSKSSSQIRMSGLPADNLAT
        .:. :.   :...:              
XP_024 SEGALQFHRGSRAQSFLQTETSVI     
          420       430             




496 residues in 1 query   sequences
64369986 residues in 92320 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Oct 24 21:55:23 2019 done: Thu Oct 24 21:55:24 2019
 Total Scan time:  4.540 Total Display time:  0.070

Function used was FASTA [36.3.4 Apr, 2011]
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