Result of FASTA (omim) for pF1KB4989
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4989, 261 aa
  1>>>pF1KB4989 261 - 261 aa - 261 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.0055+/-0.000438; mu= 12.3423+/- 0.028
 mean_var=101.1470+/-19.736, 0's: 0 Z-trim(114.0): 103  B-trim: 654 in 2/51
 Lambda= 0.127526
 statistics sampled from 23583 (23688) to 23583 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.634), E-opt: 0.2 (0.278), width:  16
 Scan time:  6.480

The best scores are:                                      opt bits E(85289)
NP_004920 (OMIM: 114050) calbindin [Homo sapiens]  ( 261) 1717 326.2 3.7e-89
NP_001731 (OMIM: 114051) calretinin isoform 1 [Hom ( 271) 1034 200.6 2.5e-51
NP_009019 (OMIM: 114051) calretinin isoform 22k [H ( 192)  642 128.3   1e-29
NP_008929 (OMIM: 609202) secretagogin [Homo sapien ( 276)  561 113.5   4e-25
XP_016865670 (OMIM: 609202) PREDICTED: secretagogi ( 222)  488 100.0 3.8e-21


>>NP_004920 (OMIM: 114050) calbindin [Homo sapiens]       (261 aa)
 initn: 1717 init1: 1717 opt: 1717  Z-score: 1721.7  bits: 326.2 E(85289): 3.7e-89
Smith-Waterman score: 1717; 100.0% identity (100.0% similar) in 261 aa overlap (1-261:1-261)

               10        20        30        40        50        60
pF1KB4 MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQQARKKAGLELSPEMKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQQARKKAGLELSPEMKT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 FVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKYDTDHSGFIET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKYDTDHSGFIET
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 EELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 FQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINNITTYKKNIMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINNITTYKKNIMA
              190       200       210       220       230       240

              250       260 
pF1KB4 LSDGGKLYRTDLALILCAGDN
       :::::::::::::::::::::
NP_004 LSDGGKLYRTDLALILCAGDN
              250       260 

>>NP_001731 (OMIM: 114051) calretinin isoform 1 [Homo sa  (271 aa)
 initn: 1227 init1: 702 opt: 1034  Z-score: 1042.4  bits: 200.6 E(85289): 2.5e-51
Smith-Waterman score: 1034; 58.7% identity (86.9% similar) in 259 aa overlap (5-258:10-267)

                    10        20        30        40        50     
pF1KB4      MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQQARKKAGL---
                .:. . .:::::.::: ::::::.::.:::::.:..:::..::: .:.   
NP_001 MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSK
               10        20        30        40        50        60

               60        70        80        90       100       110
pF1KB4 --ELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKY
         ... .:: :...: . .:::: ..:::..::::::::: :: :.. :  :::..::::
NP_001 SDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFR-QHVGSSAEFMEAWRKY
               70        80        90       100        110         

              120       130       140       150       160       170
pF1KB4 DTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARL
       :::.::.::..:::.::.:::.:::.  :. :: :::. .:..:: :.:::: :.::.::
NP_001 DTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRL
     120       130       140       150       160       170         

              180       190       200       210       220       230
pF1KB4 LPVQENFLLKFQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINN
       :::::::::::::.:. ..:::  : .::.: .:::::.::::::::: ::::....:..
NP_001 LPVQENFLLKFQGMKLTSEEFNAIFTFYDKDRSGYIDEHELDALLKDLYEKNKKEMNIQQ
     180       190       200       210       220       230         

              240       250       260  
pF1KB4 ITTYKKNIMALSDGGKLYRTDLALILCAGDN 
       .:.:.:..:.:...::::: :: ..::.    
NP_001 LTNYRKSVMSLAEAGKLYRKDLEIVLCSEPPM
     240       250       260       270 

>>NP_009019 (OMIM: 114051) calretinin isoform 22k [Homo   (192 aa)
 initn: 644 init1: 310 opt: 642  Z-score: 654.7  bits: 128.3 E(85289): 1e-29
Smith-Waterman score: 642; 56.7% identity (84.8% similar) in 171 aa overlap (5-170:10-179)

                    10        20        30        40        50     
pF1KB4      MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQQARKKAGL---
                .:. . .:::::.::: ::::::.::.:::::.:..:::..::: .:.   
NP_009 MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSK
               10        20        30        40        50        60

               60        70        80        90       100       110
pF1KB4 --ELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKY
         ... .:: :...: . .:::: ..:::..::::::::: :: :.. :  :::..::::
NP_009 SDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFR-QHVGSSAEFMEAWRKY
               70        80        90       100        110         

              120       130       140       150       160       170
pF1KB4 DTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARL
       :::.::.::..:::.::.:::.:::.  :. :: :::. .:..:: :.:::: :.::.:.
NP_009 DTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRI
     120       130       140       150       160       170         

              180       190       200       210       220       230
pF1KB4 LPVQENFLLKFQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINN
                                                                   
NP_009 EAATLTSMSWMPF                                               
     180       190                                                 

>>NP_008929 (OMIM: 609202) secretagogin [Homo sapiens]    (276 aa)
 initn: 352 init1: 352 opt: 561  Z-score: 572.0  bits: 113.5 E(85289): 4e-25
Smith-Waterman score: 561; 37.6% identity (66.5% similar) in 263 aa overlap (11-259:12-271)

                10        20        30            40        50     
pF1KB4  MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQ----NLIQELQQARKKAGLELS
                  . :. :...: .:::: .::.: :::.    .....:         .: 
NP_008 MDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHMLMKLGTDDTVMKANLH
               10        20        30        40        50        60

          60        70        80         90        100       110   
pF1KB4 PEMKTFVDQYGQRDDGKIGIVELAHVLPTE-ENFLLLFRCQQ-LKSCEEFMKTWRKYDTD
          . :.       ::.: . ::: .. .: :::::::: .. : :  :::. :::::.:
NP_008 KVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDAD
               70        80        90       100       110       120

           120       130       140       150       160       170   
pF1KB4 HSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPV
        :::: . ::.:::.::. . .:.....:: :::  :.:.:: :.::.:.:...::.: .
NP_008 SSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILAL
              130       140       150       160       170       180

           180       190            200       210       220        
pF1KB4 QENFLLKFQGIKMCGKE-----FNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDI
       ::::::.:. .  :. :     :.: :  :: . .: ..  :.:...::. :  . ... 
NP_008 QENFLLQFK-MDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISG
               190       200       210       220       230         

      230       240          250       260    
pF1KB4 NNITTYKKNIMALSD---GGKLYRTDLALILCAGDN   
        ..  ... ..   :    ::. ...::  :: :     
NP_008 VDLDKFREILLRHCDVNKDGKIQKSELA--LCLGLKINP
     240       250       260         270      

>>XP_016865670 (OMIM: 609202) PREDICTED: secretagogin is  (222 aa)
 initn: 352 init1: 352 opt: 488  Z-score: 500.7  bits: 100.0 E(85289): 3.8e-21
Smith-Waterman score: 488; 39.8% identity (68.7% similar) in 211 aa overlap (59-259:10-217)

       30        40        50        60        70        80        
pF1KB4 GYLEGKELQNLIQELQQARKKAGLELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTE-EN
                                     . :.       ::.: . ::: .. .: ::
XP_016                      MKANLHKVKQQFMTTQDASKDGRIRMKELAGMFLSEDEN
                                    10        20        30         

        90        100       110       120       130       140      
pF1KB4 FLLLFRCQQ-LKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEY
       :::::: .. : :  :::. :::::.: :::: . ::.:::.::. . .:.....:: ::
XP_016 FLLLFRRENPLDSSVEFMQIWRKYDADSSGFISAAELRNFLRDLFLHHKKAISEAKLEEY
      40        50        60        70        80        90         

        150       160       170       180       190            200 
pF1KB4 TDLMLKLFDSNNDGKLELTEMARLLPVQENFLLKFQGIKMCGKE-----FNKAFELYDQD
       :  :.:.:: :.::.:.:...::.: .::::::.:. .  :. :     :.: :  :: .
XP_016 TGTMMKIFDRNKDGRLDLNDLARILALQENFLLQFK-MDACSTEERKRDFEKIFAYYDVS
     100       110       120       130        140       150        

             210       220       230       240          250        
pF1KB4 GNGYIDENELDALLKDLCEKNKQDLDINNITTYKKNIMALSD---GGKLYRTDLALILCA
        .: ..  :.:...::. :  . ...  ..  ... ..   :    ::. ...::  :: 
XP_016 KTGALEGPEVDGFVKDMMELVQPSISGVDLDKFREILLRHCDVNKDGKIQKSELA--LCL
      160       170       180       190       200       210        

      260    
pF1KB4 GDN   
       :     
XP_016 GLKINP
        220  




261 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 06:11:55 2016 done: Sat Nov  5 06:11:56 2016
 Total Scan time:  6.480 Total Display time: -0.030

Function used was FASTA [36.3.4 Apr, 2011]
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