Result of FASTA (omim) for pF1KB4017
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4017, 464 aa
  1>>>pF1KB4017 464 - 464 aa - 464 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.8880+/-0.000375; mu= 14.9115+/- 0.023
 mean_var=81.5269+/-15.722, 0's: 0 Z-trim(114.5): 40  B-trim: 0 in 0/54
 Lambda= 0.142044
 statistics sampled from 24385 (24423) to 24385 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.671), E-opt: 0.2 (0.286), width:  16
 Scan time:  9.450

The best scores are:                                      opt bits E(85289)
XP_006716390 (OMIM: 601956) PREDICTED: GDNF family ( 464) 3198 665.2  1e-190
NP_001486 (OMIM: 601956) GDNF family receptor alph ( 464) 3198 665.2  1e-190
XP_011542786 (OMIM: 601956) PREDICTED: GDNF family ( 464) 3198 665.2  1e-190
NP_001158510 (OMIM: 601956) GDNF family receptor a ( 359) 2372 495.9 7.4e-140
NP_001158511 (OMIM: 601956) GDNF family receptor a ( 331) 2204 461.5 1.6e-129
NP_005255 (OMIM: 601496) GDNF family receptor alph ( 465) 1443 305.6 1.9e-82
XP_005269753 (OMIM: 601496) PREDICTED: GDNF family ( 465) 1443 305.6 1.9e-82
XP_011537936 (OMIM: 601496) PREDICTED: GDNF family ( 465) 1443 305.6 1.9e-82
NP_665736 (OMIM: 601496) GDNF family receptor alph ( 460) 1436 304.2   5e-82
NP_001138925 (OMIM: 601496) GDNF family receptor a ( 460) 1436 304.2   5e-82
NP_001487 (OMIM: 605710) GDNF family receptor alph ( 400)  574 127.5 6.7e-29


>>XP_006716390 (OMIM: 601956) PREDICTED: GDNF family rec  (464 aa)
 initn: 3198 init1: 3198 opt: 3198  Z-score: 3545.0  bits: 665.2 E(85289): 1e-190
Smith-Waterman score: 3198; 100.0% identity (100.0% similar) in 464 aa overlap (1-464:1-464)

               10        20        30        40        50        60
pF1KB4 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM
              370       380       390       400       410       420

              430       440       450       460    
pF1KB4 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
       ::::::::::::::::::::::::::::::::::::::::::::
XP_006 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
              430       440       450       460    

>>NP_001486 (OMIM: 601956) GDNF family receptor alpha-2   (464 aa)
 initn: 3198 init1: 3198 opt: 3198  Z-score: 3545.0  bits: 665.2 E(85289): 1e-190
Smith-Waterman score: 3198; 100.0% identity (100.0% similar) in 464 aa overlap (1-464:1-464)

               10        20        30        40        50        60
pF1KB4 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM
              370       380       390       400       410       420

              430       440       450       460    
pF1KB4 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
       ::::::::::::::::::::::::::::::::::::::::::::
NP_001 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
              430       440       450       460    

>>XP_011542786 (OMIM: 601956) PREDICTED: GDNF family rec  (464 aa)
 initn: 3198 init1: 3198 opt: 3198  Z-score: 3545.0  bits: 665.2 E(85289): 1e-190
Smith-Waterman score: 3198; 100.0% identity (100.0% similar) in 464 aa overlap (1-464:1-464)

               10        20        30        40        50        60
pF1KB4 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM
              370       380       390       400       410       420

              430       440       450       460    
pF1KB4 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
       ::::::::::::::::::::::::::::::::::::::::::::
XP_011 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
              430       440       450       460    

>>NP_001158510 (OMIM: 601956) GDNF family receptor alpha  (359 aa)
 initn: 2372 init1: 2372 opt: 2372  Z-score: 2631.9  bits: 495.9 E(85289): 7.4e-140
Smith-Waterman score: 2372; 100.0% identity (100.0% similar) in 346 aa overlap (119-464:14-359)

       90       100       110       120       130       140        
pF1KB4 PLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGT
                                     ::::::::::::::::::::::::::::::
NP_001                  MILANVFCLFFFLGEEFYEASPYEPVTSRLSDIFRLASIFSGT
                                10        20        30        40   

      150       160       170       180       190       200        
pF1KB4 GADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFF
            50        60        70        80        90       100   

      210       220       230       240       250       260        
pF1KB4 DRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRL
           110       120       130       140       150       160   

      270       280       290       300       310       320        
pF1KB4 ADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGS
           170       180       190       200       210       220   

      330       340       350       360       370       380        
pF1KB4 GNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDL
           230       240       250       260       270       280   

      390       400       410       420       430       440        
pF1KB4 SDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARP
           290       300       310       320       330       340   

      450       460    
pF1KB4 SAALTVLSVLMLKLAL
       ::::::::::::::::
NP_001 SAALTVLSVLMLKLAL
           350         

>>NP_001158511 (OMIM: 601956) GDNF family receptor alpha  (331 aa)
 initn: 2198 init1: 2198 opt: 2204  Z-score: 2446.4  bits: 461.5 E(85289): 1.6e-129
Smith-Waterman score: 2204; 97.6% identity (98.8% similar) in 330 aa overlap (135-464:3-331)

          110       120       130       140       150       160    
pF1KB4 CLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDA
                                     :...: :  .: ::::::::::::::::::
NP_001                             MILANVFCLF-FFLGTGADPVVSAKSNHCLDA
                                           10         20        30 

          170       180       190       200       210       220    
pF1KB4 AKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSC
              40        50        60        70        80        90 

          230       240       250       260       270       280    
pF1KB4 QDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTS
             100       110       120       130       140       150 

          290       300       310       320       330       340    
pF1KB4 CPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTE
             160       170       180       190       200       210 

          350       360       370       380       390       400    
pF1KB4 NPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTS
             220       230       240       250       260       270 

          410       420       430       440       450       460    
pF1KB4 VQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
             280       290       300       310       320       330 

>>NP_005255 (OMIM: 601496) GDNF family receptor alpha-1   (465 aa)
 initn: 1379 init1: 612 opt: 1443  Z-score: 1601.3  bits: 305.6 E(85289): 1.9e-82
Smith-Waterman score: 1443; 49.8% identity (75.2% similar) in 436 aa overlap (38-460:27-452)

        10        20        30        40        50        60       
pF1KB4 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR
                                     .:::.:.. :  :..::..:::::::.::.
NP_005     MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK
                   10        20        30        40        50      

        70             80        90       100       110       120  
pF1KB4 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF
       . :  ::.      ::..:.:.:... ::.:::::::::: .::.::::.. .: .:...
NP_005 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL
         60        70        80        90       100       110      

            130       140       150       160       170       180  
pF1KB4 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI
        : ::::::.::::::::.. ..: .  .     :.:.::::::::::.: ::: ::.::
NP_005 LEDSPYEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYI
         120       130       140       150       160       170     

            190       200       210       220       230       240  
pF1KB4 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS
       . :.  .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: ::
NP_005 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS
         180        190       200       210       220       230    

            250       260       270       280       290       300  
pF1KB4 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG
       ::..::::::.:.  :.:...:::::::: .::.   ..:.::  .::  :: .:.:.::
NP_005 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG
          240       250       260       270       280       290    

            310       320       330       340       350       360  
pF1KB4 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN
         :::::.:::  .. :.:::.: .:::  ::: :::  : .: ::.:::::::::.::.
NP_005 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT
          300         310       320       330       340       350  

                 370       380       390       400       410       
pF1KB4 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE
       : .:  :    .  .: : ::.. :  :   .. . . : :.  :...: : ::.: : .
NP_005 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN
            360       370       380         390       400       410

       420          430       440       450       460             
pF1KB4 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL         
         .:... .    ..  .:. . :  ..:    :: .:. : ::..             
NP_005 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS
              420       430           440       450       460     

>>XP_005269753 (OMIM: 601496) PREDICTED: GDNF family rec  (465 aa)
 initn: 1379 init1: 612 opt: 1443  Z-score: 1601.3  bits: 305.6 E(85289): 1.9e-82
Smith-Waterman score: 1443; 49.8% identity (75.2% similar) in 436 aa overlap (38-460:27-452)

        10        20        30        40        50        60       
pF1KB4 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR
                                     .:::.:.. :  :..::..:::::::.::.
XP_005     MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK
                   10        20        30        40        50      

        70             80        90       100       110       120  
pF1KB4 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF
       . :  ::.      ::..:.:.:... ::.:::::::::: .::.::::.. .: .:...
XP_005 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL
         60        70        80        90       100       110      

            130       140       150       160       170       180  
pF1KB4 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI
        : ::::::.::::::::.. ..: .  .     :.:.::::::::::.: ::: ::.::
XP_005 LEDSPYEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYI
         120       130       140       150       160       170     

            190       200       210       220       230       240  
pF1KB4 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS
       . :.  .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: ::
XP_005 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS
         180        190       200       210       220       230    

            250       260       270       280       290       300  
pF1KB4 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG
       ::..::::::.:.  :.:...:::::::: .::.   ..:.::  .::  :: .:.:.::
XP_005 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG
          240       250       260       270       280       290    

            310       320       330       340       350       360  
pF1KB4 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN
         :::::.:::  .. :.:::.: .:::  ::: :::  : .: ::.:::::::::.::.
XP_005 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT
          300         310       320       330       340       350  

                 370       380       390       400       410       
pF1KB4 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE
       : .:  :    .  .: : ::.. :  :   .. . . : :.  :...: : ::.: : .
XP_005 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN
            360       370       380         390       400       410

       420          430       440       450       460             
pF1KB4 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL         
         .:... .    ..  .:. . :  ..:    :: .:. : ::..             
XP_005 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS
              420       430           440       450       460     

>>XP_011537936 (OMIM: 601496) PREDICTED: GDNF family rec  (465 aa)
 initn: 1379 init1: 612 opt: 1443  Z-score: 1601.3  bits: 305.6 E(85289): 1.9e-82
Smith-Waterman score: 1443; 49.8% identity (75.2% similar) in 436 aa overlap (38-460:27-452)

        10        20        30        40        50        60       
pF1KB4 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR
                                     .:::.:.. :  :..::..:::::::.::.
XP_011     MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK
                   10        20        30        40        50      

        70             80        90       100       110       120  
pF1KB4 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF
       . :  ::.      ::..:.:.:... ::.:::::::::: .::.::::.. .: .:...
XP_011 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL
         60        70        80        90       100       110      

            130       140       150       160       170       180  
pF1KB4 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI
        : ::::::.::::::::.. ..: .  .     :.:.::::::::::.: ::: ::.::
XP_011 LEDSPYEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYI
         120       130       140       150       160       170     

            190       200       210       220       230       240  
pF1KB4 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS
       . :.  .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: ::
XP_011 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS
         180        190       200       210       220       230    

            250       260       270       280       290       300  
pF1KB4 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG
       ::..::::::.:.  :.:...:::::::: .::.   ..:.::  .::  :: .:.:.::
XP_011 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG
          240       250       260       270       280       290    

            310       320       330       340       350       360  
pF1KB4 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN
         :::::.:::  .. :.:::.: .:::  ::: :::  : .: ::.:::::::::.::.
XP_011 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT
          300         310       320       330       340       350  

                 370       380       390       400       410       
pF1KB4 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE
       : .:  :    .  .: : ::.. :  :   .. . . : :.  :...: : ::.: : .
XP_011 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN
            360       370       380         390       400       410

       420          430       440       450       460             
pF1KB4 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL         
         .:... .    ..  .:. . :  ..:    :: .:. : ::..             
XP_011 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS
              420       430           440       450       460     

>>NP_665736 (OMIM: 601496) GDNF family receptor alpha-1   (460 aa)
 initn: 1385 init1: 612 opt: 1436  Z-score: 1593.6  bits: 304.2 E(85289): 5e-82
Smith-Waterman score: 1436; 49.8% identity (75.5% similar) in 436 aa overlap (38-460:27-447)

        10        20        30        40        50        60       
pF1KB4 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR
                                     .:::.:.. :  :..::..:::::::.::.
NP_665     MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK
                   10        20        30        40        50      

        70             80        90       100       110       120  
pF1KB4 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF
       . :  ::.      ::..:.:.:... ::.:::::::::: .::.::::.. .: .:...
NP_665 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL
         60        70        80        90       100       110      

            130       140       150       160       170       180  
pF1KB4 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI
        : ::::::.::::::::.. ..:   .. .   :.:.::::::::::.: ::: ::.::
NP_665 LEDSPYEPVNSRLSDIFRVVPFIS---VEHI--PKGNNCLDAAKACNLDDICKKYRSAYI
         120       130          140         150       160       170

            190       200       210       220       230       240  
pF1KB4 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS
       . :.  .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: ::
NP_665 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS
               180       190       200       210       220         

            250       260       270       280       290       300  
pF1KB4 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG
       ::..::::::.:.  :.:...:::::::: .::.   ..:.::  .::  :: .:.:.::
NP_665 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG
     230       240       250       260       270       280         

            310       320       330       340       350       360  
pF1KB4 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN
         :::::.:::  .. :.:::.: .:::  ::: :::  : .: ::.:::::::::.::.
NP_665 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT
     290       300         310       320       330       340       

                 370       380       390       400       410       
pF1KB4 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE
       : .:  :    .  .: : ::.. :  :   .. . . : :.  :...: : ::.: : .
NP_665 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN
       350       360       370         380       390       400     

       420          430       440       450       460             
pF1KB4 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL         
         .:... .    ..  .:. . :  ..:    :: .:. : ::..             
NP_665 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS
         410       420       430           440       450       460

>>NP_001138925 (OMIM: 601496) GDNF family receptor alpha  (460 aa)
 initn: 1385 init1: 612 opt: 1436  Z-score: 1593.6  bits: 304.2 E(85289): 5e-82
Smith-Waterman score: 1436; 49.8% identity (75.5% similar) in 436 aa overlap (38-460:27-447)

        10        20        30        40        50        60       
pF1KB4 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR
                                     .:::.:.. :  :..::..:::::::.::.
NP_001     MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK
                   10        20        30        40        50      

        70             80        90       100       110       120  
pF1KB4 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF
       . :  ::.      ::..:.:.:... ::.:::::::::: .::.::::.. .: .:...
NP_001 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL
         60        70        80        90       100       110      

            130       140       150       160       170       180  
pF1KB4 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI
        : ::::::.::::::::.. ..:   .. .   :.:.::::::::::.: ::: ::.::
NP_001 LEDSPYEPVNSRLSDIFRVVPFIS---VEHI--PKGNNCLDAAKACNLDDICKKYRSAYI
         120       130          140         150       160       170

            190       200       210       220       230       240  
pF1KB4 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS
       . :.  .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: ::
NP_001 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS
               180       190       200       210       220         

            250       260       270       280       290       300  
pF1KB4 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG
       ::..::::::.:.  :.:...:::::::: .::.   ..:.::  .::  :: .:.:.::
NP_001 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG
     230       240       250       260       270       280         

            310       320       330       340       350       360  
pF1KB4 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN
         :::::.:::  .. :.:::.: .:::  ::: :::  : .: ::.:::::::::.::.
NP_001 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT
     290       300         310       320       330       340       

                 370       380       390       400       410       
pF1KB4 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE
       : .:  :    .  .: : ::.. :  :   .. . . : :.  :...: : ::.: : .
NP_001 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN
       350       360       370         380       390       400     

       420          430       440       450       460             
pF1KB4 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL         
         .:... .    ..  .:. . :  ..:    :: .:. : ::..             
NP_001 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS
         410       420       430           440       450       460




464 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 05:32:40 2016 done: Sat Nov  5 05:32:41 2016
 Total Scan time:  9.450 Total Display time:  0.080

Function used was FASTA [36.3.4 Apr, 2011]
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