Result of FASTA (omim) for pF1KB3738
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3738, 357 aa
  1>>>pF1KB3738 357 - 357 aa - 357 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.0522+/-0.000345; mu= 17.5757+/- 0.021
 mean_var=68.1203+/-14.116, 0's: 0 Z-trim(113.6): 66  B-trim: 749 in 1/50
 Lambda= 0.155395
 statistics sampled from 23017 (23089) to 23017 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.271), width:  16
 Scan time:  7.570

The best scores are:                                      opt bits E(85289)
NP_003095 (OMIM: 182500) sorbitol dehydrogenase [H ( 357) 2390 544.9  1e-154
NP_000658 (OMIM: 103700) alcohol dehydrogenase 1A  ( 375)  207 55.5 2.2e-07
NP_000659 (OMIM: 103720,103780) alcohol dehydrogen ( 375)  198 53.5 9.1e-07
NP_000660 (OMIM: 103730,103780,168600) alcohol deh ( 375)  197 53.3 1.1e-06
NP_000661 (OMIM: 103740) alcohol dehydrogenase 4 i ( 380)  182 49.9 1.1e-05
XP_016863204 (OMIM: 103740) PREDICTED: alcohol deh ( 387)  182 49.9 1.1e-05
NP_001293101 (OMIM: 103740) alcohol dehydrogenase  ( 399)  182 49.9 1.1e-05
NP_001293100 (OMIM: 103740) alcohol dehydrogenase  ( 399)  182 49.9 1.1e-05
XP_016863203 (OMIM: 103740) PREDICTED: alcohol deh ( 406)  182 49.9 1.2e-05
XP_016863202 (OMIM: 103740) PREDICTED: alcohol deh ( 406)  182 49.9 1.2e-05
NP_000664 (OMIM: 600086) alcohol dehydrogenase cla ( 386)  177 48.8 2.4e-05
NP_001159976 (OMIM: 600086) alcohol dehydrogenase  ( 394)  177 48.8 2.5e-05
XP_011529890 (OMIM: 103730,103780,168600) PREDICTE ( 341)  171 47.4 5.6e-05
NP_001273579 (OMIM: 103720,103780) alcohol dehydro ( 335)  170 47.2 6.4e-05
XP_011529891 (OMIM: 103730,103780,168600) PREDICTE ( 335)  168 46.7 8.8e-05
NP_000663 (OMIM: 103735) alcohol dehydrogenase 6 i ( 368)  159 44.7 0.00038
NP_001095940 (OMIM: 103735) alcohol dehydrogenase  ( 375)  159 44.7 0.00039
NP_000662 (OMIM: 103710) alcohol dehydrogenase cla ( 374)  155 43.8 0.00072
XP_016855857 (OMIM: 123691) PREDICTED: quinone oxi ( 192)  148 42.1  0.0013
NP_001128231 (OMIM: 123691) quinone oxidoreductase ( 192)  148 42.1  0.0013
XP_005270548 (OMIM: 123691) PREDICTED: quinone oxi ( 192)  148 42.1  0.0013
NP_006364 (OMIM: 604631) synaptic vesicle membrane ( 393)  149 42.5  0.0019


>>NP_003095 (OMIM: 182500) sorbitol dehydrogenase [Homo   (357 aa)
 initn: 2390 init1: 2390 opt: 2390  Z-score: 2898.7  bits: 544.9 E(85289): 1e-154
Smith-Waterman score: 2390; 99.7% identity (100.0% similar) in 357 aa overlap (1-357:1-357)

               10        20        30        40        50        60
pF1KB3 MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 IVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 ATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 AGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 GCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRY
       ::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_003 GCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRY
              250       260       270       280       290       300

              310       320       330       340       350       
pF1KB3 CNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
              310       320       330       340       350       

>>NP_000658 (OMIM: 103700) alcohol dehydrogenase 1A [Hom  (375 aa)
 initn: 264 init1: 131 opt: 207  Z-score: 253.4  bits: 55.5 E(85289): 2.2e-07
Smith-Waterman score: 372; 27.9% identity (56.1% similar) in 358 aa overlap (22-348:24-373)

                 10        20        30        40        50        
pF1KB3   MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIG
                              .:.  .  :  .:: ..: .:::::.: :       :
NP_000 MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVS----G
               10        20        30        40        50          

       60        70        80        90           100              
pF1KB3 NFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRV---AIEP-GAPR--ENDE--FC----
       ....  :..:::::.: ::.:: .:  .::::.:   ::   :  :  .: :  .:    
NP_000 TMVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKND
         60        70        80        90       100       110      

           110       120         130          140       150        
pF1KB3 ---KMGRYNLSPSIFFCATPPDDG--NLCRFYKHNAA---FCYKLPDNVTFEEGALIE-P
           .:  . . : : :   :     ..  : .....      :.     .:.  ::   
NP_000 VSNPQGTLQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCG
        120       130       140       150       160       170      

       160        170       180       190       200       210      
pF1KB3 LSVGI-HACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEI
       .:.:   :   . :: :    : : : .:. ...  :: :::.....:..  ...::::.
NP_000 FSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKEL
        180       190       200       210       220       230      

        220         230        240       250       260        270  
pF1KB3 GADLVL--QISKESPQEIARKV-EGQLGCKPEVTIECTGAEASIQAGIYATRSG-GTLVL
       ::   .  :  :.  ::. ... .: .    . ..:  :   ...:..   . . :: :.
NP_000 GATECINPQDYKKPIQEVLKEMTDGGV----DFSFEVIGRLDTMMASLLCCHEACGTSVI
        240       250       260           270       280       290  

               280       290         300       310       320       
pF1KB3 VGL---GSEMTTVPLLHAAIREVD--IKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFP
       ::.   .....  :.:  . :     : : :.  .  :  .. . .:. ..  :.:: .:
NP_000 VGVPPDSQNLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHVLP
            300       310       320       330       340       350  

       330       340       350       
pF1KB3 LEKALEAFETFKKGLGLKIMLKCDPSDQNP
       .::  :.:. ...: ... .:         
NP_000 FEKINEGFDLLHSGKSIRTILMF       
            360       370            

>>NP_000659 (OMIM: 103720,103780) alcohol dehydrogenase   (375 aa)
 initn: 262 init1: 139 opt: 198  Z-score: 242.5  bits: 53.5 E(85289): 9.1e-07
Smith-Waterman score: 362; 27.4% identity (55.6% similar) in 358 aa overlap (22-348:24-373)

                 10        20        30        40        50        
pF1KB3   MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIG
                              .:.  .  :   :: ..: .:::: .: :       :
NP_000 MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICHTDDHVVS----G
               10        20        30        40        50          

       60        70        80        90           100              
pF1KB3 NFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVA--IEP--GAPR--ENDE--FC---K
       :...  :..:::::.: ::.:: .:  .::::.:   . :  :  :  .: :  .:    
NP_000 NLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKND
         60        70        80        90       100       110      

         110         120            130       140       150        
pF1KB3 MG--RYNLSPSI--FFCATPP-----DDGNLCRFYKHNAAFCYKLPDNVTFEEGALIE-P
       .:  : .:. .   : :   :       ... ..   .     :.     .:.  ::   
NP_000 LGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCG
        120       130       140       150       160       170      

       160        170       180       190       200       210      
pF1KB3 LSVGI-HACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEI
       .:.:   :   . :: :    : : : .:. ...  :: :::.....:..  ...::::.
NP_000 FSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKEL
        180       190       200       210       220       230      

        220         230        240       250       260        270  
pF1KB3 GADLVL--QISKESPQEIARKV-EGQLGCKPEVTIECTGAEASIQAGIYATRSG-GTLVL
       ::   .  :  :.  ::. ... .: .    . ..:  :   ...:..   . . :: :.
NP_000 GATECINPQDYKKPIQEVLKEMTDGGV----DFSFEVIGRLDTMMASLLCCHEACGTSVI
        240       250       260           270       280       290  

               280       290         300       310       320       
pF1KB3 VGL---GSEMTTVPLLHAAIREVD--IKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFP
       ::.   .....  :.:  . :     . : :.  .  :  .. . .:. ..  :.:: .:
NP_000 VGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLP
            300       310       320       330       340       350  

       330       340       350       
pF1KB3 LEKALEAFETFKKGLGLKIMLKCDPSDQNP
       .::  :.:. ...: ... .:         
NP_000 FEKINEGFDLLHSGKSIRTVLTF       
            360       370            

>>NP_000660 (OMIM: 103730,103780,168600) alcohol dehydro  (375 aa)
 initn: 260 init1: 139 opt: 197  Z-score: 241.3  bits: 53.3 E(85289): 1.1e-06
Smith-Waterman score: 362; 27.7% identity (57.3% similar) in 358 aa overlap (22-348:24-373)

                 10        20        30        40        50        
pF1KB3   MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIG
                              .:.  .  :  .:: ..: ..::: :: :       :
NP_000 MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVS----G
               10        20        30        40        50          

       60        70        80        90           100              
pF1KB3 NFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVA--IEP--GAPR--ENDE--FC---K
       :...  :..:::::.: ::.:: .:  .::::.:   . :  :  :  .: :  .:    
NP_000 NLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKND
         60        70        80        90       100       110      

         110         120         130          140       150        
pF1KB3 MG--RYNLSPSI--FFCATPPDDG--NLCRFYKHNAA---FCYKLPDNVTFEEGALIE-P
       .:  : .:. .   : :.  :     ..  : .....      :.     .:.  ::   
NP_000 LGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCG
        120       130       140       150       160       170      

       160        170       180       190       200       210      
pF1KB3 LSVGI-HACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEI
       .:.:   : . . :: :    : : : .:. ...  :: :::.....:..  ...::::.
NP_000 FSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKEL
        180       190       200       210       220       230      

        220         230        240       250       260        270  
pF1KB3 GADLVL--QISKESPQEIARKV-EGQLGCKPEVTIECTGAEASIQAGIYATRSG-GTLVL
       ::   .  :  :.  ::. ... .: .    . ..:  :   ...:..   . . :: :.
NP_000 GATECINPQDYKKPIQEVLKEMTDGGV----DFSFEVIGRLDTMMASLLCCHEACGTSVI
        240       250       260           270       280       290  

               280       290         300       310       320       
pF1KB3 VGL---GSEMTTVPLLHAAIREVD--IKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFP
       ::.   .....  :.:  . :     : : :.  .. :  .. . .:. ..  :.:. .:
NP_000 VGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILP
            300       310       320       330       340       350  

       330       340       350       
pF1KB3 LEKALEAFETFKKGLGLKIMLKCDPSDQNP
       .::  :.:. ...: ... .:         
NP_000 FEKINEGFDLLRSGKSIRTVLTF       
            360       370            

>>NP_000661 (OMIM: 103740) alcohol dehydrogenase 4 isofo  (380 aa)
 initn: 255 init1: 134 opt: 182  Z-score: 223.0  bits: 49.9 E(85289): 1.1e-05
Smith-Waterman score: 344; 25.5% identity (55.6% similar) in 369 aa overlap (20-348:22-378)

                 10        20        30        40        50        
pF1KB3   MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIG
                            : .:.  .  :  .:: ... ....: .:.   .    :
NP_000 MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEG
               10        20        30        40        50        60

       60        70        80        90       100       110        
pF1KB3 NFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIF
          .  :...::::.: ::..: .: ..::::.: :   ::     .:.  .. :::   
NP_000 ---LAFPVIVGHEAAGIVESIGPGVTNVKPGDKV-IPLYAP-----LCRKCKFCLSPLTN
                  70        80        90             100       110 

      120                      130             140                 
pF1KB3 FCA------TPPDDGNL---------CR------FYKHNAAFCY---------KLPDNVT
       .:.      .: .: .:         :.      :.  ..   :         :. :...
NP_000 LCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDAN
             120       130       140       150       160       170 

      150        160        170       180       190       200      
pF1KB3 FEEGALIE-PLSVGIHAC-RRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLS
       .:.  :.   .:.:  :    . :: :    : : : .:. ...  :: ::....  :..
NP_000 LERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDIN
             180       190       200       210       220       230 

        210        220        230       240       250       260    
pF1KB3 ATRLSKAKEIGA-DLVLQISKESP-QEIARKVEGQLGCKPEVTIECTGAEASIQAGIYAT
       . .. ::: .:: : .   . ..: ::.   .:   :   . ...:.:.  ...:..  :
NP_000 SEKFVKAKALGATDCLNPRDLHKPIQEVI--IELTKG-GVDFALDCAGGSETMKAALDCT
             240       250       260          270       280        

           270          280       290         300       310        
pF1KB3 RSG-GTLVLVGL--GSE-MTTVPLLHAAIREVD--IKGVFRYCNTWPVAISMLASKSVNV
        .: :. ...:.  ::. .:  :      : ..  . : ..  .. :  ..   .:. :.
NP_000 TAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNL
      290       300       310       320       330       340        

      320       330       340       350       
pF1KB3 KPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
         :::: .:..:  :::. ...: ... .:         
NP_000 DALVTHTLPFDKISEAFDLMNQGKSVRTILIF       
      350       360       370       380       

>>XP_016863204 (OMIM: 103740) PREDICTED: alcohol dehydro  (387 aa)
 initn: 248 init1: 134 opt: 182  Z-score: 222.9  bits: 49.9 E(85289): 1.1e-05
Smith-Waterman score: 337; 25.7% identity (55.2% similar) in 362 aa overlap (20-341:22-371)

                 10        20        30        40        50        
pF1KB3   MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIG
                            : .:.  .  :  .:: ... ....: .:.   .    :
XP_016 MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEG
               10        20        30        40        50        60

       60        70        80        90       100       110        
pF1KB3 NFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIF
          .  :...::::.: ::..: .: ..::::.: :   ::     .:.  .. :::   
XP_016 ---LAFPVIVGHEAAGIVESIGPGVTNVKPGDKV-IPLYAP-----LCRKCKFCLSPLTN
                  70        80        90             100       110 

      120                      130             140                 
pF1KB3 FCA------TPPDDGNL---------CR------FYKHNAAFCY---------KLPDNVT
       .:.      .: .: .:         :.      :.  ..   :         :. :...
XP_016 LCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDAN
             120       130       140       150       160       170 

      150        160        170       180       190       200      
pF1KB3 FEEGALIE-PLSVGIHAC-RRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLS
       .:.  :.   .:.:  :    . :: :    : : : .:. ...  :: ::....  :..
XP_016 LERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDIN
             180       190       200       210       220       230 

        210        220        230       240       250       260    
pF1KB3 ATRLSKAKEIGA-DLVLQISKESP-QEIARKVEGQLGCKPEVTIECTGAEASIQAGIYAT
       . .. ::: .:: : .   . ..: ::.   .:   :   . ...:.:.  ...:..  :
XP_016 SEKFVKAKALGATDCLNPRDLHKPIQEVI--IELTKG-GVDFALDCAGGSETMKAALDCT
             240       250       260          270       280        

           270          280       290         300       310        
pF1KB3 RSG-GTLVLVGL--GSE-MTTVPLLHAAIREVD--IKGVFRYCNTWPVAISMLASKSVNV
        .: :. ...:.  ::. .:  :      : ..  . : ..  .. :  ..   .:. :.
XP_016 TAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNL
      290       300       310       320       330       340        

      320       330       340       350       
pF1KB3 KPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
         :::: .:..:  :::. ...:                
XP_016 DALVTHTLPFDKISEAFDLMNQGKSYRRSENSDYSKTKT
      350       360       370       380       

>>NP_001293101 (OMIM: 103740) alcohol dehydrogenase 4 is  (399 aa)
 initn: 255 init1: 134 opt: 182  Z-score: 222.7  bits: 49.9 E(85289): 1.1e-05
Smith-Waterman score: 344; 25.5% identity (55.6% similar) in 369 aa overlap (20-348:41-397)

                          10        20        30        40         
pF1KB3            MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDV
                                     : .:.  .  :  .:: ... ....: .:.
NP_001 QRCKTHLFSSNYLTQVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDA
               20        30        40        50        60        70

      50        60        70        80        90       100         
pF1KB3 HYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMG
          .    :   .  :...::::.: ::..: .: ..::::.: :   ::     .:.  
NP_001 TVIDSKFEG---LAFPVIVGHEAAGIVESIGPGVTNVKPGDKV-IPLYAP-----LCRKC
                  80        90       100       110             120 

     110       120                      130             140        
pF1KB3 RYNLSPSIFFCA------TPPDDGNL---------CR------FYKHNAAFCY-------
       .. :::   .:.      .: .: .:         :.      :.  ..   :       
NP_001 KFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDIN
             130       140       150       160       170       180 

               150        160        170       180       190       
pF1KB3 --KLPDNVTFEEGALIE-PLSVGIHAC-RRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGA
         :. :....:.  :.   .:.:  :    . :: :    : : : .:. ...  :: ::
NP_001 LAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGA
             190       200       210       220       230       240 

       200       210        220        230       240       250     
pF1KB3 AQVVVTDLSATRLSKAKEIGA-DLVLQISKESP-QEIARKVEGQLGCKPEVTIECTGAEA
       ....  :... .. ::: .:: : .   . ..: ::.   .:   :   . ...:.:.  
NP_001 SRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVI--IELTKG-GVDFALDCAGGSE
             250       260       270         280        290        

         260        270          280       290         300         
pF1KB3 SIQAGIYATRSG-GTLVLVGL--GSE-MTTVPLLHAAIREVD--IKGVFRYCNTWPVAIS
       ...:..  : .: :. ...:.  ::. .:  :      : ..  . : ..  .. :  ..
NP_001 TMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVT
      300       310       320       330       340       350        

     310       320       330       340       350       
pF1KB3 MLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
          .:. :.  :::: .:..:  :::. ...: ... .:         
NP_001 DYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF       
      360       370       380       390                

>>NP_001293100 (OMIM: 103740) alcohol dehydrogenase 4 is  (399 aa)
 initn: 255 init1: 134 opt: 182  Z-score: 222.7  bits: 49.9 E(85289): 1.1e-05
Smith-Waterman score: 344; 25.5% identity (55.6% similar) in 369 aa overlap (20-348:41-397)

                          10        20        30        40         
pF1KB3            MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDV
                                     : .:.  .  :  .:: ... ....: .:.
NP_001 QRCKTHLFSSNYLTQVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDA
               20        30        40        50        60        70

      50        60        70        80        90       100         
pF1KB3 HYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMG
          .    :   .  :...::::.: ::..: .: ..::::.: :   ::     .:.  
NP_001 TVIDSKFEG---LAFPVIVGHEAAGIVESIGPGVTNVKPGDKV-IPLYAP-----LCRKC
                  80        90       100       110             120 

     110       120                      130             140        
pF1KB3 RYNLSPSIFFCA------TPPDDGNL---------CR------FYKHNAAFCY-------
       .. :::   .:.      .: .: .:         :.      :.  ..   :       
NP_001 KFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDIN
             130       140       150       160       170       180 

               150        160        170       180       190       
pF1KB3 --KLPDNVTFEEGALIE-PLSVGIHAC-RRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGA
         :. :....:.  :.   .:.:  :    . :: :    : : : .:. ...  :: ::
NP_001 LAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGA
             190       200       210       220       230       240 

       200       210        220        230       240       250     
pF1KB3 AQVVVTDLSATRLSKAKEIGA-DLVLQISKESP-QEIARKVEGQLGCKPEVTIECTGAEA
       ....  :... .. ::: .:: : .   . ..: ::.   .:   :   . ...:.:.  
NP_001 SRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVI--IELTKG-GVDFALDCAGGSE
             250       260       270         280        290        

         260        270          280       290         300         
pF1KB3 SIQAGIYATRSG-GTLVLVGL--GSE-MTTVPLLHAAIREVD--IKGVFRYCNTWPVAIS
       ...:..  : .: :. ...:.  ::. .:  :      : ..  . : ..  .. :  ..
NP_001 TMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVT
      300       310       320       330       340       350        

     310       320       330       340       350       
pF1KB3 MLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
          .:. :.  :::: .:..:  :::. ...: ... .:         
NP_001 DYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF       
      360       370       380       390                

>>XP_016863203 (OMIM: 103740) PREDICTED: alcohol dehydro  (406 aa)
 initn: 248 init1: 134 opt: 182  Z-score: 222.6  bits: 49.9 E(85289): 1.2e-05
Smith-Waterman score: 337; 25.7% identity (55.2% similar) in 362 aa overlap (20-341:41-390)

                          10        20        30        40         
pF1KB3            MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDV
                                     : .:.  .  :  .:: ... ....: .:.
XP_016 QRCKTHLFSSNYLTQVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDA
               20        30        40        50        60        70

      50        60        70        80        90       100         
pF1KB3 HYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMG
          .    :   .  :...::::.: ::..: .: ..::::.: :   ::     .:.  
XP_016 TVIDSKFEG---LAFPVIVGHEAAGIVESIGPGVTNVKPGDKV-IPLYAP-----LCRKC
                  80        90       100       110             120 

     110       120                      130             140        
pF1KB3 RYNLSPSIFFCA------TPPDDGNL---------CR------FYKHNAAFCY-------
       .. :::   .:.      .: .: .:         :.      :.  ..   :       
XP_016 KFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDIN
             130       140       150       160       170       180 

               150        160        170       180       190       
pF1KB3 --KLPDNVTFEEGALIE-PLSVGIHAC-RRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGA
         :. :....:.  :.   .:.:  :    . :: :    : : : .:. ...  :: ::
XP_016 LAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGA
             190       200       210       220       230       240 

       200       210        220        230       240       250     
pF1KB3 AQVVVTDLSATRLSKAKEIGA-DLVLQISKESP-QEIARKVEGQLGCKPEVTIECTGAEA
       ....  :... .. ::: .:: : .   . ..: ::.   .:   :   . ...:.:.  
XP_016 SRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVI--IELTKG-GVDFALDCAGGSE
             250       260       270         280        290        

         260        270          280       290         300         
pF1KB3 SIQAGIYATRSG-GTLVLVGL--GSE-MTTVPLLHAAIREVD--IKGVFRYCNTWPVAIS
       ...:..  : .: :. ...:.  ::. .:  :      : ..  . : ..  .. :  ..
XP_016 TMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVT
      300       310       320       330       340       350        

     310       320       330       340       350       
pF1KB3 MLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
          .:. :.  :::: .:..:  :::. ...:                
XP_016 DYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSYRRSENSDYSKTKT
      360       370       380       390       400      

>>XP_016863202 (OMIM: 103740) PREDICTED: alcohol dehydro  (406 aa)
 initn: 248 init1: 134 opt: 182  Z-score: 222.6  bits: 49.9 E(85289): 1.2e-05
Smith-Waterman score: 337; 25.7% identity (55.2% similar) in 362 aa overlap (20-341:41-390)

                          10        20        30        40         
pF1KB3            MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDV
                                     : .:.  .  :  .:: ... ....: .:.
XP_016 QRCKTHLFSSNYLTQVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDA
               20        30        40        50        60        70

      50        60        70        80        90       100         
pF1KB3 HYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMG
          .    :   .  :...::::.: ::..: .: ..::::.: :   ::     .:.  
XP_016 TVIDSKFEG---LAFPVIVGHEAAGIVESIGPGVTNVKPGDKV-IPLYAP-----LCRKC
                  80        90       100       110             120 

     110       120                      130             140        
pF1KB3 RYNLSPSIFFCA------TPPDDGNL---------CR------FYKHNAAFCY-------
       .. :::   .:.      .: .: .:         :.      :.  ..   :       
XP_016 KFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDIN
             130       140       150       160       170       180 

               150        160        170       180       190       
pF1KB3 --KLPDNVTFEEGALIE-PLSVGIHAC-RRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGA
         :. :....:.  :.   .:.:  :    . :: :    : : : .:. ...  :: ::
XP_016 LAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGA
             190       200       210       220       230       240 

       200       210        220        230       240       250     
pF1KB3 AQVVVTDLSATRLSKAKEIGA-DLVLQISKESP-QEIARKVEGQLGCKPEVTIECTGAEA
       ....  :... .. ::: .:: : .   . ..: ::.   .:   :   . ...:.:.  
XP_016 SRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVI--IELTKG-GVDFALDCAGGSE
             250       260       270         280        290        

         260        270          280       290         300         
pF1KB3 SIQAGIYATRSG-GTLVLVGL--GSE-MTTVPLLHAAIREVD--IKGVFRYCNTWPVAIS
       ...:..  : .: :. ...:.  ::. .:  :      : ..  . : ..  .. :  ..
XP_016 TMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVT
      300       310       320       330       340       350        

     310       320       330       340       350       
pF1KB3 MLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
          .:. :.  :::: .:..:  :::. ...:                
XP_016 DYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSYRRSENSDYSKTKT
      360       370       380       390       400      




357 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 05:21:07 2016 done: Sat Nov  5 05:21:08 2016
 Total Scan time:  7.570 Total Display time:  0.030

Function used was FASTA [36.3.4 Apr, 2011]
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