Result of FASTA (omim) for pF1KE0809
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0809, 335 aa
  1>>>pF1KE0809 335 - 335 aa - 335 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 3.7903+/-0.000432; mu= 25.1546+/- 0.027
 mean_var=108.0256+/-31.504, 0's: 0 Z-trim(110.8): 467  B-trim: 1130 in 1/51
 Lambda= 0.123399
 statistics sampled from 18606 (19263) to 18606 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.594), E-opt: 0.2 (0.226), width:  16
 Scan time:  7.120

The best scores are:                                      opt bits E(85289)
NP_848566 (OMIM: 300513) glucose-dependent insulin ( 335) 2192 401.6 1.2e-111
NP_000665 (OMIM: 102775) adenosine receptor A1 [Ho ( 326)  317 67.8 3.7e-11
NP_001041695 (OMIM: 102775) adenosine receptor A1  ( 326)  317 67.8 3.7e-11
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359)  316 67.7 4.4e-11
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362)  316 67.7 4.4e-11
NP_001124527 (OMIM: 142703) histamine H2 receptor  ( 397)  316 67.7 4.6e-11
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422)  316 67.8 4.7e-11
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422)  316 67.8 4.7e-11
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422)  316 67.8 4.7e-11
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422)  316 67.8 4.7e-11
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422)  316 67.8 4.7e-11
NP_778227 (OMIM: 608282) trace amine-associated re ( 348)  293 63.5 7.4e-10
NP_001307659 (OMIM: 601974) sphingosine 1-phosphat ( 382)  284 62.0 2.3e-09
NP_001391 (OMIM: 601974) sphingosine 1-phosphate r ( 382)  284 62.0 2.3e-09
NP_001265616 (OMIM: 182453) somatostatin receptor  ( 418)  281 61.5 3.5e-09
XP_016884413 (OMIM: 182453) PREDICTED: somatostati ( 418)  281 61.5 3.5e-09
XP_005261778 (OMIM: 182453) PREDICTED: somatostati ( 418)  281 61.5 3.5e-09
XP_011528651 (OMIM: 182453) PREDICTED: somatostati ( 418)  281 61.5 3.5e-09
XP_016884412 (OMIM: 182453) PREDICTED: somatostati ( 418)  281 61.5 3.5e-09
NP_001042 (OMIM: 182453) somatostatin receptor typ ( 418)  281 61.5 3.5e-09
XP_006724374 (OMIM: 182453) PREDICTED: somatostati ( 418)  281 61.5 3.5e-09
NP_778237 (OMIM: 608923) trace amine-associated re ( 345)  267 58.9 1.8e-08
NP_000668 (OMIM: 600445) adenosine receptor A3 iso ( 318)  266 58.7   2e-08
NP_005675 (OMIM: 604106) probable G-protein couple ( 361)  266 58.8 2.1e-08
NP_001041 (OMIM: 182452) somatostatin receptor typ ( 369)  262 58.1 3.5e-08
NP_000904 (OMIM: 602548) nociceptin receptor isofo ( 370)  257 57.2 6.5e-08
XP_016883343 (OMIM: 602548) PREDICTED: nociceptin  ( 370)  257 57.2 6.5e-08
NP_872588 (OMIM: 602548) nociceptin receptor isofo ( 370)  257 57.2 6.5e-08
NP_001186948 (OMIM: 602548) nociceptin receptor is ( 370)  257 57.2 6.5e-08
XP_016883341 (OMIM: 602548) PREDICTED: nociceptin  ( 388)  257 57.2 6.6e-08
XP_016883342 (OMIM: 602548) PREDICTED: nociceptin  ( 388)  257 57.2 6.6e-08
XP_011527130 (OMIM: 602548) PREDICTED: nociceptin  ( 388)  257 57.2 6.6e-08
NP_001305782 (OMIM: 602548) nociceptin receptor is ( 399)  257 57.2 6.7e-08
NP_001159687 (OMIM: 605146) sphingosine 1-phosphat ( 398)  256 57.1 7.6e-08
NP_110387 (OMIM: 605146) sphingosine 1-phosphate r ( 398)  256 57.1 7.6e-08
XP_005251990 (OMIM: 601909) PREDICTED: probable G- ( 349)  254 56.6 9.1e-08
NP_005285 (OMIM: 601909) probable G-protein couple ( 349)  254 56.6 9.1e-08
XP_016872446 (OMIM: 606665) PREDICTED: melanopsin  ( 405)  252 56.4 1.2e-07
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440)  252 56.4 1.3e-07
NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478)  252 56.5 1.3e-07
NP_001025186 (OMIM: 606665) melanopsin isoform 2 [ ( 489)  252 56.5 1.4e-07
XP_016872445 (OMIM: 606665) PREDICTED: melanopsin  ( 528)  252 56.6 1.4e-07
XP_016872444 (OMIM: 606665) PREDICTED: melanopsin  ( 539)  252 56.6 1.4e-07
NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380)  249 55.8 1.8e-07
NP_001040 (OMIM: 182451) somatostatin receptor typ ( 391)  249 55.8 1.8e-07
NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409)  249 55.8 1.8e-07
XP_016883344 (OMIM: 602548) PREDICTED: nociceptin  ( 365)  248 55.6 1.9e-07
NP_001305783 (OMIM: 602548) nociceptin receptor is ( 365)  248 55.6 1.9e-07
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic  ( 477)  249 56.0   2e-07
NP_001091682 (OMIM: 600167) histamine H1 receptor  ( 487)  249 56.0   2e-07


>>NP_848566 (OMIM: 300513) glucose-dependent insulinotro  (335 aa)
 initn: 2192 init1: 2192 opt: 2192  Z-score: 2125.2  bits: 401.6 E(85289): 1.2e-111
Smith-Waterman score: 2192; 100.0% identity (100.0% similar) in 335 aa overlap (1-335:1-335)

               10        20        30        40        50        60
pF1KE0 MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_848 MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 LLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_848 LLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 VAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_848 VAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 FVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_848 FVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 FLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_848 FLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKV
              250       260       270       280       290       300

              310       320       330     
pF1KE0 LTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
       :::::::::::::::::::::::::::::::::::
NP_848 LTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
              310       320       330     

>>NP_000665 (OMIM: 102775) adenosine receptor A1 [Homo s  (326 aa)
 initn: 316 init1: 147 opt: 317  Z-score: 321.3  bits: 67.8 E(85289): 3.7e-11
Smith-Waterman score: 347; 26.5% identity (57.5% similar) in 306 aa overlap (3-293:6-302)

                  10          20        30        40        50     
pF1KE0    MESSFSFGVI-LAVLASLI-IATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIG
            :.:. . : . :: .:. .  :.::  :: .     :. ..:: ..:::::. .:
NP_000 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDA-TFCFIVSLAVADVAVG
               10        20        30        40         50         

          60        70        80        90       100       110     
pF1KE0 VAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLK
       . .  :    : . .  :    : .    :   . .:.:... :. :::: .: :.::  
NP_000 ALVIPLAI--LINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKM
      60          70        80        90       100       110       

         120       130       140            150              160   
pF1KE0 IMSGFVAGACIAGLWLVSYLIGFLPL----GIPMFQQT-AYKG-------QCSFFAVFHP
       ...   :.. ::: :..:...:. :.    ..   ... : .:       .: :  :.  
NP_000 VVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISM
       120       130       140       150       160       170       

           170        180       190       200       210       220  
pF1KE0 HFVLTLSC-VGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFK
       .... ..  :  .: .::.:..:   :..  .  .:. :   :..   :  .    ...:
NP_000 EYMVYFNFFVWVLPPLLLMVLIY---LEVFYLIRKQLNKKVSASS---GDPQKYYGKELK
       180       190       200          210          220       230 

            230       240       250       260       270       280  
pF1KE0 ALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYW
         .......  ::::: :. : . . . :  ::   .:     .:  ::: .::..::. 
NP_000 IAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFR
             240       250       260       270       280       290 

            290       300       310       320       330     
pF1KE0 QKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
        .. :. . ..                                          
NP_000 IQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD                  
             300       310       320                        

>>NP_001041695 (OMIM: 102775) adenosine receptor A1 [Hom  (326 aa)
 initn: 316 init1: 147 opt: 317  Z-score: 321.3  bits: 67.8 E(85289): 3.7e-11
Smith-Waterman score: 347; 26.5% identity (57.5% similar) in 306 aa overlap (3-293:6-302)

                  10          20        30        40        50     
pF1KE0    MESSFSFGVI-LAVLASLI-IATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIG
            :.:. . : . :: .:. .  :.::  :: .     :. ..:: ..:::::. .:
NP_001 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDA-TFCFIVSLAVADVAVG
               10        20        30        40         50         

          60        70        80        90       100       110     
pF1KE0 VAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLK
       . .  :    : . .  :    : .    :   . .:.:... :. :::: .: :.::  
NP_001 ALVIPLAI--LINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKM
      60          70        80        90       100       110       

         120       130       140            150              160   
pF1KE0 IMSGFVAGACIAGLWLVSYLIGFLPL----GIPMFQQT-AYKG-------QCSFFAVFHP
       ...   :.. ::: :..:...:. :.    ..   ... : .:       .: :  :.  
NP_001 VVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISM
       120       130       140       150       160       170       

           170        180       190       200       210       220  
pF1KE0 HFVLTLSC-VGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFK
       .... ..  :  .: .::.:..:   :..  .  .:. :   :..   :  .    ...:
NP_001 EYMVYFNFFVWVLPPLLLMVLIY---LEVFYLIRKQLNKKVSASS---GDPQKYYGKELK
       180       190       200          210          220       230 

            230       240       250       260       270       280  
pF1KE0 ALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYW
         .......  ::::: :. : . . . :  ::   .:     .:  ::: .::..::. 
NP_001 IAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFR
             240       250       260       270       280       290 

            290       300       310       320       330     
pF1KE0 QKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
        .. :. . ..                                          
NP_001 IQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD                  
             300       310       320                        

>>NP_071640 (OMIM: 142703) histamine H2 receptor isoform  (359 aa)
 initn: 228 init1: 164 opt: 316  Z-score: 320.0  bits: 67.7 E(85289): 4.4e-11
Smith-Waterman score: 316; 25.2% identity (60.1% similar) in 286 aa overlap (9-287:23-296)

                             10        20        30        40      
pF1KE0               MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLN
                             :.::::  . .: :..: .:: :  ..  ... :: ..
NP_071 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGL-NRRLRNLTNCFIVS
               10        20        30        40         50         

         50        60        70        80        90       100      
pF1KE0 LAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLA
       ::..: :.:. .  . .    : .    :..:..  .. .   .::.:....:..::: :
NP_071 LAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCA
      60        70        80        90       100       110         

        110       120       130       140         150              
pF1KE0 IKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLP--LGIPMFQQTAYKG-----QCSFFA
       . .:.::  ...   ..  .. .:..:  ..::   ::    ..:. ::     .:.  .
NP_071 VMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS-KGNHTTSKCK--V
     120       130       140       150       160        170        

     160       170       180       190       200       210         
pF1KE0 VFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPS
         .  . :. . : :.  .:.. . :  ..:.:    .: ....: ..  ..     :  
NP_071 QVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVAR---DQAKRINHISSWKAA-----TIR
        180       190       200       210          220             

     220       230       240       250       260       270         
pF1KE0 DFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIY
       . ::  :.....:.: . : :.. . . .    .  .  :::  .  :: .:: :::..:
NP_071 EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILY
      230       240       250       260       270       280        

     280       290       300       310       320       330         
pF1KE0 AYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG    
       :  ... :                                                    
NP_071 AALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGT
      290       300       310       320       330       340        

>>XP_006714928 (OMIM: 142703) PREDICTED: histamine H2 re  (362 aa)
 initn: 228 init1: 164 opt: 316  Z-score: 319.9  bits: 67.7 E(85289): 4.4e-11
Smith-Waterman score: 316; 25.2% identity (60.1% similar) in 286 aa overlap (9-287:23-296)

                             10        20        30        40      
pF1KE0               MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLN
                             :.::::  . .: :..: .:: :  ..  ... :: ..
XP_006 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGL-NRRLRNLTNCFIVS
               10        20        30        40         50         

         50        60        70        80        90       100      
pF1KE0 LAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLA
       ::..: :.:. .  . .    : .    :..:..  .. .   .::.:....:..::: :
XP_006 LAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCA
      60        70        80        90       100       110         

        110       120       130       140         150              
pF1KE0 IKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLP--LGIPMFQQTAYKG-----QCSFFA
       . .:.::  ...   ..  .. .:..:  ..::   ::    ..:. ::     .:.  .
XP_006 VMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS-KGNHTTSKCK--V
     120       130       140       150       160        170        

     160       170       180       190       200       210         
pF1KE0 VFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPS
         .  . :. . : :.  .:.. . :  ..:.:    .: ....: ..  ..     :  
XP_006 QVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVAR---DQAKRINHISSWKAA-----TIR
        180       190       200       210          220             

     220       230       240       250       260       270         
pF1KE0 DFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIY
       . ::  :.....:.: . : :.. . . .    .  .  :::  .  :: .:: :::..:
XP_006 EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILY
      230       240       250       260       270       280        

     280       290       300       310       320       330         
pF1KE0 AYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG    
       :  ... :                                                    
XP_006 AALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGT
      290       300       310       320       330       340        

>>NP_001124527 (OMIM: 142703) histamine H2 receptor isof  (397 aa)
 initn: 228 init1: 164 opt: 316  Z-score: 319.6  bits: 67.7 E(85289): 4.6e-11
Smith-Waterman score: 316; 25.2% identity (60.1% similar) in 286 aa overlap (9-287:23-296)

                             10        20        30        40      
pF1KE0               MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLN
                             :.::::  . .: :..: .:: :  ..  ... :: ..
NP_001 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGL-NRRLRNLTNCFIVS
               10        20        30        40         50         

         50        60        70        80        90       100      
pF1KE0 LAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLA
       ::..: :.:. .  . .    : .    :..:..  .. .   .::.:....:..::: :
NP_001 LAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCA
      60        70        80        90       100       110         

        110       120       130       140         150              
pF1KE0 IKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLP--LGIPMFQQTAYKG-----QCSFFA
       . .:.::  ...   ..  .. .:..:  ..::   ::    ..:. ::     .:.  .
NP_001 VMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS-KGNHTTSKCK--V
     120       130       140       150       160        170        

     160       170       180       190       200       210         
pF1KE0 VFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPS
         .  . :. . : :.  .:.. . :  ..:.:    .: ....: ..  ..     :  
NP_001 QVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVAR---DQAKRINHISSWKAA-----TIR
        180       190       200       210          220             

     220       230       240       250       260       270         
pF1KE0 DFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIY
       . ::  :.....:.: . : :.. . . .    .  .  :::  .  :: .:: :::..:
NP_001 EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILY
      230       240       250       260       270       280        

     280       290       300       310       320       330         
pF1KE0 AYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG    
       :  ... :                                                    
NP_001 AALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGT
      290       300       310       320       330       340        

>>XP_006714927 (OMIM: 142703) PREDICTED: histamine H2 re  (422 aa)
 initn: 228 init1: 164 opt: 316  Z-score: 319.4  bits: 67.8 E(85289): 4.7e-11
Smith-Waterman score: 316; 25.2% identity (60.1% similar) in 286 aa overlap (9-287:23-296)

                             10        20        30        40      
pF1KE0               MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLN
                             :.::::  . .: :..: .:: :  ..  ... :: ..
XP_006 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGL-NRRLRNLTNCFIVS
               10        20        30        40         50         

         50        60        70        80        90       100      
pF1KE0 LAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLA
       ::..: :.:. .  . .    : .    :..:..  .. .   .::.:....:..::: :
XP_006 LAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCA
      60        70        80        90       100       110         

        110       120       130       140         150              
pF1KE0 IKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLP--LGIPMFQQTAYKG-----QCSFFA
       . .:.::  ...   ..  .. .:..:  ..::   ::    ..:. ::     .:.  .
XP_006 VMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS-KGNHTTSKCK--V
     120       130       140       150       160        170        

     160       170       180       190       200       210         
pF1KE0 VFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPS
         .  . :. . : :.  .:.. . :  ..:.:    .: ....: ..  ..     :  
XP_006 QVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVAR---DQAKRINHISSWKAA-----TIR
        180       190       200       210          220             

     220       230       240       250       260       270         
pF1KE0 DFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIY
       . ::  :.....:.: . : :.. . . .    .  .  :::  .  :: .:: :::..:
XP_006 EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILY
      230       240       250       260       270       280        

     280       290       300       310       320       330         
pF1KE0 AYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG    
       :  ... :                                                    
XP_006 AALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGT
      290       300       310       320       330       340        

>>XP_011532851 (OMIM: 142703) PREDICTED: histamine H2 re  (422 aa)
 initn: 228 init1: 164 opt: 316  Z-score: 319.4  bits: 67.8 E(85289): 4.7e-11
Smith-Waterman score: 316; 25.2% identity (60.1% similar) in 286 aa overlap (9-287:23-296)

                             10        20        30        40      
pF1KE0               MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLN
                             :.::::  . .: :..: .:: :  ..  ... :: ..
XP_011 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGL-NRRLRNLTNCFIVS
               10        20        30        40         50         

         50        60        70        80        90       100      
pF1KE0 LAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLA
       ::..: :.:. .  . .    : .    :..:..  .. .   .::.:....:..::: :
XP_011 LAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCA
      60        70        80        90       100       110         

        110       120       130       140         150              
pF1KE0 IKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLP--LGIPMFQQTAYKG-----QCSFFA
       . .:.::  ...   ..  .. .:..:  ..::   ::    ..:. ::     .:.  .
XP_011 VMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS-KGNHTTSKCK--V
     120       130       140       150       160        170        

     160       170       180       190       200       210         
pF1KE0 VFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPS
         .  . :. . : :.  .:.. . :  ..:.:    .: ....: ..  ..     :  
XP_011 QVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVAR---DQAKRINHISSWKAA-----TIR
        180       190       200       210          220             

     220       230       240       250       260       270         
pF1KE0 DFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIY
       . ::  :.....:.: . : :.. . . .    .  .  :::  .  :: .:: :::..:
XP_011 EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILY
      230       240       250       260       270       280        

     280       290       300       310       320       330         
pF1KE0 AYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG    
       :  ... :                                                    
XP_011 AALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGT
      290       300       310       320       330       340        

>>XP_016864915 (OMIM: 142703) PREDICTED: histamine H2 re  (422 aa)
 initn: 228 init1: 164 opt: 316  Z-score: 319.4  bits: 67.8 E(85289): 4.7e-11
Smith-Waterman score: 316; 25.2% identity (60.1% similar) in 286 aa overlap (9-287:23-296)

                             10        20        30        40      
pF1KE0               MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLN
                             :.::::  . .: :..: .:: :  ..  ... :: ..
XP_016 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGL-NRRLRNLTNCFIVS
               10        20        30        40         50         

         50        60        70        80        90       100      
pF1KE0 LAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLA
       ::..: :.:. .  . .    : .    :..:..  .. .   .::.:....:..::: :
XP_016 LAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCA
      60        70        80        90       100       110         

        110       120       130       140         150              
pF1KE0 IKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLP--LGIPMFQQTAYKG-----QCSFFA
       . .:.::  ...   ..  .. .:..:  ..::   ::    ..:. ::     .:.  .
XP_016 VMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS-KGNHTTSKCK--V
     120       130       140       150       160        170        

     160       170       180       190       200       210         
pF1KE0 VFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPS
         .  . :. . : :.  .:.. . :  ..:.:    .: ....: ..  ..     :  
XP_016 QVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVAR---DQAKRINHISSWKAA-----TIR
        180       190       200       210          220             

     220       230       240       250       260       270         
pF1KE0 DFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIY
       . ::  :.....:.: . : :.. . . .    .  .  :::  .  :: .:: :::..:
XP_016 EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILY
      230       240       250       260       270       280        

     280       290       300       310       320       330         
pF1KE0 AYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG    
       :  ... :                                                    
XP_016 AALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGT
      290       300       310       320       330       340        

>>XP_005265961 (OMIM: 142703) PREDICTED: histamine H2 re  (422 aa)
 initn: 228 init1: 164 opt: 316  Z-score: 319.4  bits: 67.8 E(85289): 4.7e-11
Smith-Waterman score: 316; 25.2% identity (60.1% similar) in 286 aa overlap (9-287:23-296)

                             10        20        30        40      
pF1KE0               MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLN
                             :.::::  . .: :..: .:: :  ..  ... :: ..
XP_005 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGL-NRRLRNLTNCFIVS
               10        20        30        40         50         

         50        60        70        80        90       100      
pF1KE0 LAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLA
       ::..: :.:. .  . .    : .    :..:..  .. .   .::.:....:..::: :
XP_005 LAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCA
      60        70        80        90       100       110         

        110       120       130       140         150              
pF1KE0 IKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLP--LGIPMFQQTAYKG-----QCSFFA
       . .:.::  ...   ..  .. .:..:  ..::   ::    ..:. ::     .:.  .
XP_005 VMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS-KGNHTTSKCK--V
     120       130       140       150       160        170        

     160       170       180       190       200       210         
pF1KE0 VFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPS
         .  . :. . : :.  .:.. . :  ..:.:    .: ....: ..  ..     :  
XP_005 QVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVAR---DQAKRINHISSWKAA-----TIR
        180       190       200       210          220             

     220       230       240       250       260       270         
pF1KE0 DFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIY
       . ::  :.....:.: . : :.. . . .    .  .  :::  .  :: .:: :::..:
XP_005 EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILY
      230       240       250       260       270       280        

     280       290       300       310       320       330         
pF1KE0 AYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG    
       :  ... :                                                    
XP_005 AALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGT
      290       300       310       320       330       340        




335 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 03:16:39 2016 done: Sat Nov  5 03:16:40 2016
 Total Scan time:  7.120 Total Display time:  0.020

Function used was FASTA [36.3.4 Apr, 2011]
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