Result of FASTA (omim) for pF1KE0645
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0645, 217 aa
  1>>>pF1KE0645 217 - 217 aa - 217 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.2478+/-0.00057; mu= -0.5441+/- 0.034
 mean_var=423.5044+/-98.908, 0's: 0 Z-trim(115.0): 199  B-trim: 0 in 0/52
 Lambda= 0.062323
 statistics sampled from 25011 (25202) to 25011 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.295), width:  16
 Scan time:  4.800

The best scores are:                                      opt bits E(85289)
NP_006604 (OMIM: 604330) GRB2-related adapter prot ( 217) 1484 147.6 1.5e-35
XP_016879518 (OMIM: 604330) PREDICTED: GRB2-relate ( 217) 1484 147.6 1.5e-35
NP_002077 (OMIM: 108355) growth factor receptor-bo ( 217)  930 97.8 1.5e-20
NP_001317077 (OMIM: 604330) GRB2-related adapter p ( 205)  662 73.7 2.5e-13
NP_004801 (OMIM: 604518) GRB2-related adapter prot ( 330)  542 63.2 5.8e-10
NP_001278754 (OMIM: 604518) GRB2-related adapter p ( 330)  542 63.2 5.8e-10
NP_001278753 (OMIM: 604518) GRB2-related adapter p ( 330)  542 63.2 5.8e-10
XP_006724439 (OMIM: 604518) PREDICTED: GRB2-relate ( 258)  326 43.6 0.00036
NP_001278755 (OMIM: 604518) GRB2-related adapter p ( 258)  326 43.6 0.00036
NP_001129473 (OMIM: 164690) Abelson tyrosine-prote ( 542)  328 44.3 0.00046
NP_005148 (OMIM: 189980) tyrosine-protein kinase A (1130)  332 45.2 0.00052
NP_009297 (OMIM: 189980) tyrosine-protein kinase A (1149)  332 45.2 0.00053
NP_001161711 (OMIM: 164690) Abelson tyrosine-prote (1043)  328 44.8 0.00065
NP_001161710 (OMIM: 164690) Abelson tyrosine-prote (1058)  328 44.8 0.00065
NP_001129472 (OMIM: 164690) Abelson tyrosine-prote (1064)  328 44.8 0.00065
NP_001161709 (OMIM: 164690) Abelson tyrosine-prote (1079)  328 44.8 0.00066
XP_005245145 (OMIM: 164690) PREDICTED: Abelson tyr (1146)  328 44.8 0.00068
NP_001161708 (OMIM: 164690) Abelson tyrosine-prote (1161)  328 44.8 0.00068
NP_005149 (OMIM: 164690) Abelson tyrosine-protein  (1167)  328 44.8 0.00068
NP_009298 (OMIM: 164690) Abelson tyrosine-protein  (1182)  328 44.9 0.00069
XP_016856524 (OMIM: 164690) PREDICTED: Abelson tyr (1182)  328 44.9 0.00069
NP_987102 (OMIM: 108355) growth factor receptor-bo ( 176)  288 39.9  0.0031


>>NP_006604 (OMIM: 604330) GRB2-related adapter protein   (217 aa)
 initn: 1484 init1: 1484 opt: 1484  Z-score: 759.3  bits: 147.6 E(85289): 1.5e-35
Smith-Waterman score: 1484; 100.0% identity (100.0% similar) in 217 aa overlap (1-217:1-217)

               10        20        30        40        50        60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
              130       140       150       160       170       180

              190       200       210       
pF1KE0 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
       :::::::::::::::::::::::::::::::::::::
NP_006 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
              190       200       210       

>>XP_016879518 (OMIM: 604330) PREDICTED: GRB2-related ad  (217 aa)
 initn: 1484 init1: 1484 opt: 1484  Z-score: 759.3  bits: 147.6 E(85289): 1.5e-35
Smith-Waterman score: 1484; 100.0% identity (100.0% similar) in 217 aa overlap (1-217:1-217)

               10        20        30        40        50        60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
              130       140       150       160       170       180

              190       200       210       
pF1KE0 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
       :::::::::::::::::::::::::::::::::::::
XP_016 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
              190       200       210       

>>NP_002077 (OMIM: 108355) growth factor receptor-bound   (217 aa)
 initn: 934 init1: 724 opt: 930  Z-score: 490.1  bits: 97.8 E(85289): 1.5e-20
Smith-Waterman score: 930; 59.7% identity (85.6% similar) in 216 aa overlap (1-216:1-214)

               10        20        30        40        50        60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
       ::..: :.:.:: .:::.:..:: ::.:: : ::::::::: : .::::::::..:::::
NP_002 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
       . :.: :  :::.: :. : ::::::::::.::.::.::..:..::::::::...:::::
NP_002 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
       :  ::::::::::..:.:......:::::: : . ..:   ..:: :::. :. ..:.::
NP_002 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQP--TYVQALFDFDPQEDGELGFR
              130       140       150         160       170        

              190       200       210         
pF1KE0 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL  
       :::.:.:..  ::.::.:   :..:.:::.:: ::.   
NP_002 RGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
      180       190       200       210       

>>NP_001317077 (OMIM: 604330) GRB2-related adapter prote  (205 aa)
 initn: 680 init1: 662 opt: 662  Z-score: 360.1  bits: 73.7 E(85289): 2.5e-13
Smith-Waterman score: 662; 99.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101)

               10        20        30        40        50        60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
       ::::::::::::::::::::::::::::::::::::::::.                   
NP_001 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNHLGPALPRPSLTSQPRTPRS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
                                                                   
NP_001 SASAVATSLRSWSAQTPTGGGAGPAGALASSHGVTCSPCTCEQPGGRSGQRAFLQELRSR
              130       140       150       160       170       180

>>NP_004801 (OMIM: 604518) GRB2-related adapter protein   (330 aa)
 initn: 676 init1: 326 opt: 542  Z-score: 299.9  bits: 63.2 E(85289): 5.8e-10
Smith-Waterman score: 542; 52.7% identity (82.7% similar) in 150 aa overlap (1-150:1-147)

               10        20        30        40        50        60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
       ::.:: ..: :.  :::.:. ::.::::.  ....:.:::: . ::..:::.: ..   :
NP_004 MEAVAKFDFTASGEDELSFHTGDVLKILS--NQEEWFKAELGSQEGYVPKNFIDIQFPKW
               10        20          30        40        50        

               70        80        90       100       110       120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
       .   .::. ::..:: .. .: :.:: :.::::.::.:: . :.::::::.:. .:.:::
NP_004 FHEGLSRHQAENLLMGKE-VGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL
       60        70         80        90       100       110       

              130       140       150       160       170       180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
       : ::: :::.:::.:::..:....::::::                              
NP_004 WTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEE
       120       130       140       150       160       170       

>>NP_001278754 (OMIM: 604518) GRB2-related adapter prote  (330 aa)
 initn: 676 init1: 326 opt: 542  Z-score: 299.9  bits: 63.2 E(85289): 5.8e-10
Smith-Waterman score: 542; 52.7% identity (82.7% similar) in 150 aa overlap (1-150:1-147)

               10        20        30        40        50        60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
       ::.:: ..: :.  :::.:. ::.::::.  ....:.:::: . ::..:::.: ..   :
NP_001 MEAVAKFDFTASGEDELSFHTGDVLKILS--NQEEWFKAELGSQEGYVPKNFIDIQFPKW
               10        20          30        40        50        

               70        80        90       100       110       120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
       .   .::. ::..:: .. .: :.:: :.::::.::.:: . :.::::::.:. .:.:::
NP_001 FHEGLSRHQAENLLMGKE-VGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL
       60        70         80        90       100       110       

              130       140       150       160       170       180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
       : ::: :::.:::.:::..:....::::::                              
NP_001 WTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEE
       120       130       140       150       160       170       

>>NP_001278753 (OMIM: 604518) GRB2-related adapter prote  (330 aa)
 initn: 676 init1: 326 opt: 542  Z-score: 299.9  bits: 63.2 E(85289): 5.8e-10
Smith-Waterman score: 542; 52.7% identity (82.7% similar) in 150 aa overlap (1-150:1-147)

               10        20        30        40        50        60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
       ::.:: ..: :.  :::.:. ::.::::.  ....:.:::: . ::..:::.: ..   :
NP_001 MEAVAKFDFTASGEDELSFHTGDVLKILS--NQEEWFKAELGSQEGYVPKNFIDIQFPKW
               10        20          30        40        50        

               70        80        90       100       110       120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
       .   .::. ::..:: .. .: :.:: :.::::.::.:: . :.::::::.:. .:.:::
NP_001 FHEGLSRHQAENLLMGKE-VGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL
       60        70         80        90       100       110       

              130       140       150       160       170       180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
       : ::: :::.:::.:::..:....::::::                              
NP_001 WTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEE
       120       130       140       150       160       170       

>>XP_006724439 (OMIM: 604518) PREDICTED: GRB2-related ad  (258 aa)
 initn: 481 init1: 326 opt: 326  Z-score: 195.9  bits: 43.6 E(85289): 0.00036
Smith-Waterman score: 326; 63.4% identity (90.1% similar) in 71 aa overlap (80-150:5-75)

      50        60        70        80        90       100         
pF1KE0 KNYIRVKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFK
                                     .: :.:: :.::::.::.:: . :.:::::
XP_006                           MGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFK
                                         10        20        30    

     110       120       130       140       150       160         
pF1KE0 VLREASGKYFLWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDF
       :.:. .:.:::: ::: :::.:::.:::..:....::::::                   
XP_006 VMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQG
           40        50        60        70        80        90    

     170       180       190       200       210                   
pF1KE0 SAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL            
                                                                   
XP_006 GPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHH
          100       110       120       130       140       150    

>>NP_001278755 (OMIM: 604518) GRB2-related adapter prote  (258 aa)
 initn: 481 init1: 326 opt: 326  Z-score: 195.9  bits: 43.6 E(85289): 0.00036
Smith-Waterman score: 326; 63.4% identity (90.1% similar) in 71 aa overlap (80-150:5-75)

      50        60        70        80        90       100         
pF1KE0 KNYIRVKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFK
                                     .: :.:: :.::::.::.:: . :.:::::
NP_001                           MGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFK
                                         10        20        30    

     110       120       130       140       150       160         
pF1KE0 VLREASGKYFLWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDF
       :.:. .:.:::: ::: :::.:::.:::..:....::::::                   
NP_001 VMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQG
           40        50        60        70        80        90    

     170       180       190       200       210                   
pF1KE0 SAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL            
                                                                   
NP_001 GPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHH
          100       110       120       130       140       150    

>>NP_001129473 (OMIM: 164690) Abelson tyrosine-protein k  (542 aa)
 initn: 300 init1: 135 opt: 328  Z-score: 193.9  bits: 44.3 E(85289): 0.00046
Smith-Waterman score: 328; 35.6% identity (68.1% similar) in 160 aa overlap (4-158:92-248)

                                          10        20        30   
pF1KE0                            MESVALYSFQATESDELAFNKGDTLKILNMEDD
                                     ::::.: :. .. :...::. :..:.....
NP_001 DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN
              70        80        90       100       110       120 

            40        50            60        70        80         
pF1KE0 QNWYKAELRGVEGFIPKNYIR----VKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESE
        .: ... .. .:..:.:::     .. : :: : .::. :: .: .  . :.::.::::
NP_001 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESE
             130       140       150       160       170        180

      90       100       110        120       130       140        
pF1KE0 SSPGEFSVSVNYGDQVQHFKVLREASGK-YFLWEEKFNSLNELVDFYRTTTIAKKRQIFL
       ::::..:.:. :  .: :...   :.:: :   : .:..: :::  .  .:.:      :
NP_001 SSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHH--STVADGLVTTL
              190       200       210       220         230        

      150       160       170       180       190       200        
pF1KE0 RDEEPLLKSPGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFP
       .   :  ..:                                                  
NP_001 HYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTL
      240       250       260       270       280       290        




217 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 19:11:32 2016 done: Wed Nov  2 19:11:33 2016
 Total Scan time:  4.800 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
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