FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0425, 373 aa 1>>>pF1KE0425 373 - 373 aa - 373 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7706+/-0.000423; mu= 19.2773+/- 0.026 mean_var=66.6965+/-13.638, 0's: 0 Z-trim(111.2): 44 B-trim: 22 in 1/52 Lambda= 0.157044 statistics sampled from 19748 (19792) to 19748 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.232), width: 16 Scan time: 7.540 The best scores are: opt bits E(85289) NP_001123237 (OMIM: 300275,300831,308050) sterol-4 ( 373) 2485 572.3 6.3e-163 XP_011529480 (OMIM: 300275,300831,308050) PREDICTE ( 373) 2485 572.3 6.3e-163 NP_057006 (OMIM: 300275,300831,308050) sterol-4-al ( 373) 2485 572.3 6.3e-163 XP_016885053 (OMIM: 300275,300831,308050) PREDICTE ( 389) 2485 572.3 6.5e-163 XP_011521773 (OMIM: 616164) PREDICTED: short-chain ( 390) 514 125.7 1.8e-28 XP_011521774 (OMIM: 616164) PREDICTED: short-chain ( 390) 514 125.7 1.8e-28 XP_005256314 (OMIM: 616164) PREDICTED: short-chain ( 393) 514 125.7 1.8e-28 NP_660151 (OMIM: 616164) short-chain dehydrogenase ( 393) 514 125.7 1.8e-28 NP_001315544 (OMIM: 109715) 3 beta-hydroxysteroid ( 373) 324 82.7 1.5e-15 NP_000853 (OMIM: 109715) 3 beta-hydroxysteroid deh ( 373) 324 82.7 1.5e-15 XP_016856608 (OMIM: 109715) PREDICTED: 3 beta-hydr ( 375) 324 82.7 1.6e-15 NP_000189 (OMIM: 201810,613890) 3 beta-hydroxyster ( 372) 303 77.9 4.2e-14 NP_001159592 (OMIM: 201810,613890) 3 beta-hydroxys ( 372) 303 77.9 4.2e-14 XP_011544262 (OMIM: 607764,607765) PREDICTED: 3 be ( 369) 286 74.1 6e-13 XP_005255658 (OMIM: 607764,607765) PREDICTED: 3 be ( 369) 286 74.1 6e-13 NP_079469 (OMIM: 607764,607765) 3 beta-hydroxyster ( 369) 286 74.1 6e-13 XP_011544263 (OMIM: 607764,607765) PREDICTED: 3 be ( 369) 286 74.1 6e-13 XP_016860499 (OMIM: 609749) PREDICTED: UDP-glucuro ( 357) 210 56.8 8.9e-08 XP_006712838 (OMIM: 609749) PREDICTED: UDP-glucuro ( 362) 210 56.8 9e-08 XP_016860498 (OMIM: 609749) PREDICTED: UDP-glucuro ( 366) 210 56.8 9.1e-08 XP_016860497 (OMIM: 609749) PREDICTED: UDP-glucuro ( 371) 210 56.8 9.2e-08 XP_011510205 (OMIM: 609749) PREDICTED: UDP-glucuro ( 414) 210 56.9 1e-07 XP_011510204 (OMIM: 609749) PREDICTED: UDP-glucuro ( 419) 210 56.9 1e-07 NP_079352 (OMIM: 609749) UDP-glucuronic acid decar ( 420) 210 56.9 1e-07 NP_001240804 (OMIM: 609749) UDP-glucuronic acid de ( 425) 210 56.9 1e-07 XP_011510206 (OMIM: 609749) PREDICTED: UDP-glucuro ( 365) 195 53.4 9.6e-07 XP_016860500 (OMIM: 609749) PREDICTED: UDP-glucuro ( 355) 189 52.1 2.4e-06 XP_016860501 (OMIM: 609749) PREDICTED: UDP-glucuro ( 355) 189 52.1 2.4e-06 XP_016860502 (OMIM: 609749) PREDICTED: UDP-glucuro ( 312) 169 47.5 5e-05 NP_001136249 (OMIM: 607764,607765) 3 beta-hydroxys ( 196) 162 45.7 0.00011 XP_011544264 (OMIM: 607764,607765) PREDICTED: 3 be ( 196) 162 45.7 0.00011 XP_016879221 (OMIM: 607764,607765) PREDICTED: 3 be ( 196) 162 45.7 0.00011 NP_001136250 (OMIM: 607764,607765) 3 beta-hydroxys ( 196) 162 45.7 0.00011 XP_011519367 (OMIM: 616145,616146) PREDICTED: dTDP ( 318) 157 44.8 0.00034 NP_001291359 (OMIM: 616145,616146) dTDP-D-glucose ( 318) 157 44.8 0.00034 XP_011519368 (OMIM: 616145,616146) PREDICTED: dTDP ( 318) 157 44.8 0.00034 XP_016860503 (OMIM: 609749) PREDICTED: UDP-glucuro ( 252) 137 40.2 0.0065 NP_001240805 (OMIM: 609749) UDP-glucuronic acid de ( 252) 137 40.2 0.0065 >>NP_001123237 (OMIM: 300275,300831,308050) sterol-4-alp (373 aa) initn: 2485 init1: 2485 opt: 2485 Z-score: 3046.0 bits: 572.3 E(85289): 6.3e-163 Smith-Waterman score: 2485; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373) 10 20 30 40 50 60 pF1KE0 MEPAVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEPAVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GYAVNVFDIQQGFDNPQVRFFLGDLCSRQDLYPALKGVNTVFHCASPPPSSNNKELFYRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYAVNVFDIQQGFDNPQVRFFLGDLCSRQDLYPALKGVNTVFHCASPPPSSNNKELFYRV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 NYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYAMKPIDYYTETKILQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYAMKPIDYYTETKILQE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 RAVLGANDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAVLGANDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 ENVVHGHILAAEQLSRDSTLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENVVHGHILAAEQLSRDSTLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 YYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAKKAMGYQPLVTMDDAME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAKKAMGYQPLVTMDDAME 310 320 330 340 350 360 370 pF1KE0 RTVQSFRHLRRVK ::::::::::::: NP_001 RTVQSFRHLRRVK 370 >>XP_011529480 (OMIM: 300275,300831,308050) PREDICTED: s (373 aa) initn: 2485 init1: 2485 opt: 2485 Z-score: 3046.0 bits: 572.3 E(85289): 6.3e-163 Smith-Waterman score: 2485; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373) 10 20 30 40 50 60 pF1KE0 MEPAVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEPAVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GYAVNVFDIQQGFDNPQVRFFLGDLCSRQDLYPALKGVNTVFHCASPPPSSNNKELFYRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GYAVNVFDIQQGFDNPQVRFFLGDLCSRQDLYPALKGVNTVFHCASPPPSSNNKELFYRV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 NYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYAMKPIDYYTETKILQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYAMKPIDYYTETKILQE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 RAVLGANDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAVLGANDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 ENVVHGHILAAEQLSRDSTLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENVVHGHILAAEQLSRDSTLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 YYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAKKAMGYQPLVTMDDAME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAKKAMGYQPLVTMDDAME 310 320 330 340 350 360 370 pF1KE0 RTVQSFRHLRRVK ::::::::::::: XP_011 RTVQSFRHLRRVK 370 >>NP_057006 (OMIM: 300275,300831,308050) sterol-4-alpha- (373 aa) initn: 2485 init1: 2485 opt: 2485 Z-score: 3046.0 bits: 572.3 E(85289): 6.3e-163 Smith-Waterman score: 2485; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373) 10 20 30 40 50 60 pF1KE0 MEPAVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MEPAVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GYAVNVFDIQQGFDNPQVRFFLGDLCSRQDLYPALKGVNTVFHCASPPPSSNNKELFYRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GYAVNVFDIQQGFDNPQVRFFLGDLCSRQDLYPALKGVNTVFHCASPPPSSNNKELFYRV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 NYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYAMKPIDYYTETKILQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 NYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYAMKPIDYYTETKILQE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 RAVLGANDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 RAVLGANDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 ENVVHGHILAAEQLSRDSTLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 ENVVHGHILAAEQLSRDSTLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 YYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAKKAMGYQPLVTMDDAME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 YYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAKKAMGYQPLVTMDDAME 310 320 330 340 350 360 370 pF1KE0 RTVQSFRHLRRVK ::::::::::::: NP_057 RTVQSFRHLRRVK 370 >>XP_016885053 (OMIM: 300275,300831,308050) PREDICTED: s (389 aa) initn: 2485 init1: 2485 opt: 2485 Z-score: 3045.8 bits: 572.3 E(85289): 6.5e-163 Smith-Waterman score: 2485; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:17-389) 10 20 30 40 pF1KE0 MEPAVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIG :::::::::::::::::::::::::::::::::::::::::::: XP_016 MRKEKLITNGTIFCFEMEPAVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 GSGFLGQHMVEQLLARGYAVNVFDIQQGFDNPQVRFFLGDLCSRQDLYPALKGVNTVFHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSGFLGQHMVEQLLARGYAVNVFDIQQGFDNPQVRFFLGDLCSRQDLYPALKGVNTVFHC 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 ASPPPSSNNKELFYRVNYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASPPPSSNNKELFYRVNYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPY 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 AMKPIDYYTETKILQERAVLGANDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAARNGKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMKPIDYYTETKILQERAVLGANDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAARNGKM 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE0 KFVIGNGKNLVDFTFVENVVHGHILAAEQLSRDSTLGGKAFHITNDEPIPFWTFLSRILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KFVIGNGKNLVDFTFVENVVHGHILAAEQLSRDSTLGGKAFHITNDEPIPFWTFLSRILT 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE0 GLNYEAPKYHIPYWVAYYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLNYEAPKYHIPYWVAYYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAK 310 320 330 340 350 360 350 360 370 pF1KE0 KAMGYQPLVTMDDAMERTVQSFRHLRRVK ::::::::::::::::::::::::::::: XP_016 KAMGYQPLVTMDDAMERTVQSFRHLRRVK 370 380 >>XP_011521773 (OMIM: 616164) PREDICTED: short-chain deh (390 aa) initn: 447 init1: 171 opt: 514 Z-score: 632.3 bits: 125.7 E(85289): 1.8e-28 Smith-Waterman score: 563; 34.5% identity (66.1% similar) in 319 aa overlap (61-360:29-345) 40 50 60 70 80 pF1KE0 KVNQNQAKRCTVIGGSGFLGQHMVEQLLARGYAVNVFDIQQGFDN-PQ-VRFFLGDLCSR : : .:::.. .. :. ..:. ::. XP_011 MHSEGLRMSQEDLDQPHLDCLGCALNQNGVHVILFDISSPAQTIPEGIKFIQGDIRHL 10 20 30 40 50 90 100 110 120 130 140 pF1KE0 QDLYPALKG--VNTVFHCASPPPSSN---NKELFYRVNYIGTKNVIETCKEAGVQKLILT .:. :.. :. ::: :: :. :..:. .:: :: :....:.. : .:. : XP_011 SDVEKAFQDADVTCVFHIASYGMSGREQLNRNLIKEVNVRGTDNILQVCQRRRVPRLVYT 60 70 80 90 100 110 150 160 170 180 190 pF1KE0 SSASVIFEGVDIKNGTEDLPYA---MKPIDYYTETKILQERAVLGAN----DPEKNFLTT :. .::: : :.:: :.::: ..: :.:..:: . :. :: :: : . : : XP_011 STFNVIFGGQVIRNGDESLPYLPLHLHP-DHYSRTKSIAEQKVLEANATPLDRGDGVLRT 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE0 -AIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFVENVVHGHILAAEQLS :.:: ::.:: . . .: .. ..: .::: :. ..::.:. :.:.:..::::.: : XP_011 CALRPAGIYGPGEQRHLPRIVSYIEKGLFKFVYGDPRSLVEFVHVDNLVQAHILASEALR 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE0 RDS--TLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVAYYLALLLSLLVMV :. .:. . :.. .:. . :. .. ::.: :. ..: ..: .:.: .. .. XP_011 ADKGHIASGQPYFISDGRPVNNFEFFRPLVEGLGYTFPSTRLPLTLVYCFAFLTEMVHFI 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE0 ISPVIQLQPTFTPMRVALAGTFHYYSCERAKKAMGY--QPLVTMDDAMERTVQSFRHLRR .. . ..:: .: .: .:. ::.: :.::: .:: ::. ...:.: XP_011 LGRLYNFQPFLTRTEVYKTGVTHYFSLEKAKKELGYKAQPF-DLQEAVEWFKAHGHGRSS 300 310 320 330 340 350 pF1KE0 VK XP_011 GSRDSECFVWDGLLVFLLIIAVLMWLPSSVILSL 360 370 380 390 >>XP_011521774 (OMIM: 616164) PREDICTED: short-chain deh (390 aa) initn: 447 init1: 171 opt: 514 Z-score: 632.3 bits: 125.7 E(85289): 1.8e-28 Smith-Waterman score: 563; 34.5% identity (66.1% similar) in 319 aa overlap (61-360:29-345) 40 50 60 70 80 pF1KE0 KVNQNQAKRCTVIGGSGFLGQHMVEQLLARGYAVNVFDIQQGFDN-PQ-VRFFLGDLCSR : : .:::.. .. :. ..:. ::. XP_011 MHSEGLRMSQEDLDQPHLDCLGCALNQNGVHVILFDISSPAQTIPEGIKFIQGDIRHL 10 20 30 40 50 90 100 110 120 130 140 pF1KE0 QDLYPALKG--VNTVFHCASPPPSSN---NKELFYRVNYIGTKNVIETCKEAGVQKLILT .:. :.. :. ::: :: :. :..:. .:: :: :....:.. : .:. : XP_011 SDVEKAFQDADVTCVFHIASYGMSGREQLNRNLIKEVNVRGTDNILQVCQRRRVPRLVYT 60 70 80 90 100 110 150 160 170 180 190 pF1KE0 SSASVIFEGVDIKNGTEDLPYA---MKPIDYYTETKILQERAVLGAN----DPEKNFLTT :. .::: : :.:: :.::: ..: :.:..:: . :. :: :: : . : : XP_011 STFNVIFGGQVIRNGDESLPYLPLHLHP-DHYSRTKSIAEQKVLEANATPLDRGDGVLRT 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE0 -AIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFVENVVHGHILAAEQLS :.:: ::.:: . . .: .. ..: .::: :. ..::.:. :.:.:..::::.: : XP_011 CALRPAGIYGPGEQRHLPRIVSYIEKGLFKFVYGDPRSLVEFVHVDNLVQAHILASEALR 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE0 RDS--TLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVAYYLALLLSLLVMV :. .:. . :.. .:. . :. .. ::.: :. ..: ..: .:.: .. .. XP_011 ADKGHIASGQPYFISDGRPVNNFEFFRPLVEGLGYTFPSTRLPLTLVYCFAFLTEMVHFI 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE0 ISPVIQLQPTFTPMRVALAGTFHYYSCERAKKAMGY--QPLVTMDDAMERTVQSFRHLRR .. . ..:: .: .: .:. ::.: :.::: .:: ::. ...:.: XP_011 LGRLYNFQPFLTRTEVYKTGVTHYFSLEKAKKELGYKAQPF-DLQEAVEWFKAHGHGRSS 300 310 320 330 340 350 pF1KE0 VK XP_011 GSRDSECFVWDGLLVFLLIIAVLMWLPSSVILSL 360 370 380 390 >>XP_005256314 (OMIM: 616164) PREDICTED: short-chain deh (393 aa) initn: 503 init1: 171 opt: 514 Z-score: 632.3 bits: 125.7 E(85289): 1.8e-28 Smith-Waterman score: 604; 33.8% identity (65.3% similar) in 346 aa overlap (34-360:5-348) 10 20 30 40 50 60 pF1KE0 AVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLARGYA ..: . . ::::..: .. : : XP_005 MDPKRSQKESVLITGGSGYFGFRLGCALNQNGVH 10 20 30 70 80 90 100 110 pF1KE0 VNVFDIQQGFDN-PQ-VRFFLGDLCSRQDLYPALKG--VNTVFHCASPPPSSN---NKEL : .:::.. .. :. ..:. ::. .:. :.. :. ::: :: :. :..: XP_005 VILFDISSPAQTIPEGIKFIQGDIRHLSDVEKAFQDADVTCVFHIASYGMSGREQLNRNL 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE0 FYRVNYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYA---MKPIDYYT . .:: :: :....:.. : .:. ::. .::: : :.:: :.::: ..: :.:. XP_005 IKEVNVRGTDNILQVCQRRRVPRLVYTSTFNVIFGGQVIRNGDESLPYLPLHLHP-DHYS 100 110 120 130 140 150 180 190 200 210 220 pF1KE0 ETKILQERAVLGAN----DPEKNFLTT-AIRPHGIFGPRDPQLVPILIEAARNGKMKFVI .:: . :. :: :: : . : : :.:: ::.:: . . .: .. ..: .::: XP_005 RTKSIAEQKVLEANATPLDRGDGVLRTCALRPAGIYGPGEQRHLPRIVSYIEKGLFKFVY 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE0 GNGKNLVDFTFVENVVHGHILAAEQLSRDS--TLGGKAFHITNDEPIPFWTFLSRILTGL :. ..::.:. :.:.:..::::.: : :. .:. . :.. .:. . :. .. :: XP_005 GDPRSLVEFVHVDNLVQAHILASEALRADKGHIASGQPYFISDGRPVNNFEFFRPLVEGL 220 230 240 250 260 270 290 300 310 320 330 340 pF1KE0 NYEAPKYHIPYWVAYYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAKKA .: :. ..: ..: .:.: .. .... . ..:: .: .: .:. ::.: :.::: XP_005 GYTFPSTRLPLTLVYCFAFLTEMVHFILGRLYNFQPFLTRTEVYKTGVTHYFSLEKAKKE 280 290 300 310 320 330 350 360 370 pF1KE0 MGY--QPLVTMDDAMERTVQSFRHLRRVK .:: ::. ...:.: XP_005 LGYKAQPF-DLQEAVEWFKAHGHGRSSGSRDSECFVWDGLLVFLLIIAVLMWLPSSVILS 340 350 360 370 380 390 >>NP_660151 (OMIM: 616164) short-chain dehydrogenase/red (393 aa) initn: 503 init1: 171 opt: 514 Z-score: 632.3 bits: 125.7 E(85289): 1.8e-28 Smith-Waterman score: 604; 33.8% identity (65.3% similar) in 346 aa overlap (34-360:5-348) 10 20 30 40 50 60 pF1KE0 AVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLARGYA ..: . . ::::..: .. : : NP_660 MDPKRSQKESVLITGGSGYFGFRLGCALNQNGVH 10 20 30 70 80 90 100 110 pF1KE0 VNVFDIQQGFDN-PQ-VRFFLGDLCSRQDLYPALKG--VNTVFHCASPPPSSN---NKEL : .:::.. .. :. ..:. ::. .:. :.. :. ::: :: :. :..: NP_660 VILFDISSPAQTIPEGIKFIQGDIRHLSDVEKAFQDADVTCVFHIASYGMSGREQLNRNL 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE0 FYRVNYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYA---MKPIDYYT . .:: :: :....:.. : .:. ::. .::: : :.:: :.::: ..: :.:. NP_660 IKEVNVRGTDNILQVCQRRRVPRLVYTSTFNVIFGGQVIRNGDESLPYLPLHLHP-DHYS 100 110 120 130 140 150 180 190 200 210 220 pF1KE0 ETKILQERAVLGAN----DPEKNFLTT-AIRPHGIFGPRDPQLVPILIEAARNGKMKFVI .:: . :. :: :: : . : : :.:: ::.:: . . .: .. ..: .::: NP_660 RTKSIAEQKVLEANATPLDRGDGVLRTCALRPAGIYGPGEQRHLPRIVSYIEKGLFKFVY 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE0 GNGKNLVDFTFVENVVHGHILAAEQLSRDS--TLGGKAFHITNDEPIPFWTFLSRILTGL :. ..::.:. :.:.:..::::.: : :. .:. . :.. .:. . :. .. :: NP_660 GDPRSLVEFVHVDNLVQAHILASEALRADKGHIASGQPYFISDGRPVNNFEFFRPLVEGL 220 230 240 250 260 270 290 300 310 320 330 340 pF1KE0 NYEAPKYHIPYWVAYYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAKKA .: :. ..: ..: .:.: .. .... . ..:: .: .: .:. ::.: :.::: NP_660 GYTFPSTRLPLTLVYCFAFLTEMVHFILGRLYNFQPFLTRTEVYKTGVTHYFSLEKAKKE 280 290 300 310 320 330 350 360 370 pF1KE0 MGY--QPLVTMDDAMERTVQSFRHLRRVK .:: ::. ...:.: NP_660 LGYKAQPF-DLQEAVEWFKAHGHGRSSGSRDSECFVWDGLLVFLLIIAVLMWLPSSVILS 340 350 360 370 380 390 >>NP_001315544 (OMIM: 109715) 3 beta-hydroxysteroid dehy (373 aa) initn: 206 init1: 70 opt: 324 Z-score: 399.9 bits: 82.7 E(85289): 1.5e-15 Smith-Waterman score: 378; 27.2% identity (58.9% similar) in 353 aa overlap (40-364:6-355) 10 20 30 40 50 60 pF1KE0 RDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLARGY--AVNVF : : :..:::::.... :. . . :. NP_001 MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVL 10 20 30 70 80 90 100 110 pF1KE0 D------IQQGFDNPQVRFFL----GDLCSRQDLYPALKGVNTVFH--CASPPPSSNNKE : ... :.. : . : ::. .. : : . :....: : . ...: NP_001 DKAFGPELREEFSKLQNKTKLTVLEGDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRE 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE0 LFYRVNYIGTKNVIETCKEAGVQKLILTSSASVI----FEGVDIKNGTEDLPYAMKPIDY .. :: ::. ..:.: .:.: .: ::: : .. . :.:: :. : NP_001 SIMNVNVKGTQLLLEACVQASVPVFIYTSSIEVAGPNSYKEI-IQNGHEEEPLENTWPAP 100 110 120 130 140 150 180 190 200 210 220 pF1KE0 YTETKILQERAVLGANDPE-KN---FLTTAIRPHGIFGPRDPQLVPILIEAARNGKMKFV : ..: : :.:::.:: . :: . : :.:: :.: . : . :: :. . NP_001 YPHSKKLAEKAVLAANGWNLKNGGTLYTCALRPMYIYGEGSRFLSASINEALNNNGILSS 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE0 IGNGKNLVDFTFVENVVHGHILAAEQLS---RDSTLGGKAFHITNDEPIPFWTFLSRILT .:. .. :. ..: ::. .:::: . :. . .. :. ..:..: : . :. :. NP_001 VGKFST-VNPVYVGNVAWAHILALRALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLS 220 230 240 250 260 270 290 300 310 320 330 340 pF1KE0 ---GLNYEAPKYHIPYWVAYYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCE :: .. .. .: . :....:: .. ... :. .: :. :.:... .: . NP_001 KEFGLRLDS-RWSFPLSLMYWIGFLLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYK 280 290 300 310 320 330 350 360 370 pF1KE0 RAKKAMGYQPLVTMDDAMERTVQSFRHLRRVK .:.. ..:.:: . ..: ..::. NP_001 KAQRDLAYKPLYSWEEAKQKTVEWVGSLVDRHKETLKSKTQ 340 350 360 370 >>NP_000853 (OMIM: 109715) 3 beta-hydroxysteroid dehydro (373 aa) initn: 206 init1: 70 opt: 324 Z-score: 399.9 bits: 82.7 E(85289): 1.5e-15 Smith-Waterman score: 378; 27.2% identity (58.9% similar) in 353 aa overlap (40-364:6-355) 10 20 30 40 50 60 pF1KE0 RDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLARGY--AVNVF : : :..:::::.... :. . . :. NP_000 MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVL 10 20 30 70 80 90 100 110 pF1KE0 D------IQQGFDNPQVRFFL----GDLCSRQDLYPALKGVNTVFH--CASPPPSSNNKE : ... :.. : . : ::. .. : : . :....: : . ...: NP_000 DKAFGPELREEFSKLQNKTKLTVLEGDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRE 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE0 LFYRVNYIGTKNVIETCKEAGVQKLILTSSASVI----FEGVDIKNGTEDLPYAMKPIDY .. :: ::. ..:.: .:.: .: ::: : .. . :.:: :. : NP_000 SIMNVNVKGTQLLLEACVQASVPVFIYTSSIEVAGPNSYKEI-IQNGHEEEPLENTWPAP 100 110 120 130 140 150 180 190 200 210 220 pF1KE0 YTETKILQERAVLGANDPE-KN---FLTTAIRPHGIFGPRDPQLVPILIEAARNGKMKFV : ..: : :.:::.:: . :: . : :.:: :.: . : . :: :. . NP_000 YPHSKKLAEKAVLAANGWNLKNGGTLYTCALRPMYIYGEGSRFLSASINEALNNNGILSS 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE0 IGNGKNLVDFTFVENVVHGHILAAEQLS---RDSTLGGKAFHITNDEPIPFWTFLSRILT .:. .. :. ..: ::. .:::: . :. . .. :. ..:..: : . :. :. NP_000 VGKFST-VNPVYVGNVAWAHILALRALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLS 220 230 240 250 260 270 290 300 310 320 330 340 pF1KE0 ---GLNYEAPKYHIPYWVAYYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCE :: .. .. .: . :....:: .. ... :. .: :. :.:... .: . NP_000 KEFGLRLDS-RWSFPLSLMYWIGFLLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYK 280 290 300 310 320 330 350 360 370 pF1KE0 RAKKAMGYQPLVTMDDAMERTVQSFRHLRRVK .:.. ..:.:: . ..: ..::. NP_000 KAQRDLAYKPLYSWEEAKQKTVEWVGSLVDRHKETLKSKTQ 340 350 360 370 373 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 10:36:41 2016 done: Thu Nov 3 10:36:42 2016 Total Scan time: 7.540 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]