FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0311, 1265 aa 1>>>pF1KE0311 1265 - 1265 aa - 1265 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.5127+/-0.000576; mu= 7.4671+/- 0.036 mean_var=160.3473+/-31.969, 0's: 0 Z-trim(109.8): 92 B-trim: 106 in 1/53 Lambda= 0.101285 statistics sampled from 18004 (18090) to 18004 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.536), E-opt: 0.2 (0.212), width: 16 Scan time: 11.590 The best scores are: opt bits E(85289) NP_689737 (OMIM: 612425) shugoshin 2 isoform 1 [Ho (1265) 8145 1203.9 0 XP_005246402 (OMIM: 612425) PREDICTED: shugoshin-l (1265) 8145 1203.9 0 XP_011509036 (OMIM: 612425) PREDICTED: shugoshin-l (1265) 8145 1203.9 0 XP_005246401 (OMIM: 612425) PREDICTED: shugoshin-l (1280) 8145 1203.9 0 XP_016858942 (OMIM: 612425) PREDICTED: shugoshin-l (1295) 8145 1203.9 0 XP_016858941 (OMIM: 612425) PREDICTED: shugoshin-l (1295) 8145 1203.9 0 NP_001153518 (OMIM: 612425) shugoshin 2 isoform 3 (1261) 8112 1199.1 0 XP_016858943 (OMIM: 612425) PREDICTED: shugoshin-l (1291) 8112 1199.1 0 NP_001153505 (OMIM: 612425) shugoshin 2 isoform 2 (1260) 7782 1150.8 0 NP_001242982 (OMIM: 188000,610855) ankyrin repeat (1709) 222 46.2 0.0023 NP_055730 (OMIM: 188000,610855) ankyrin repeat dom (1710) 222 46.2 0.0023 XP_016871421 (OMIM: 188000,610855) PREDICTED: anky (2031) 222 46.2 0.0026 XP_006717488 (OMIM: 188000,610855) PREDICTED: anky (2031) 222 46.2 0.0026 XP_016871419 (OMIM: 188000,610855) PREDICTED: anky (2062) 222 46.2 0.0027 XP_011517718 (OMIM: 188000,610855) PREDICTED: anky (2062) 222 46.2 0.0027 XP_016871420 (OMIM: 188000,610855) PREDICTED: anky (2062) 222 46.2 0.0027 XP_006717486 (OMIM: 188000,610855) PREDICTED: anky (2072) 222 46.2 0.0027 XP_016871418 (OMIM: 188000,610855) PREDICTED: anky (2108) 222 46.2 0.0027 XP_016871417 (OMIM: 188000,610855) PREDICTED: anky (2112) 222 46.2 0.0027 >>NP_689737 (OMIM: 612425) shugoshin 2 isoform 1 [Homo s (1265 aa) initn: 8145 init1: 8145 opt: 8145 Z-score: 6440.4 bits: 1203.9 E(85289): 0 Smith-Waterman score: 8145; 99.7% identity (99.9% similar) in 1265 aa overlap (1-1265:1-1265) 10 20 30 40 50 60 pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 ATEMSSLSEFHQSSFLLSASKKKRVSKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI : ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: NP_689 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 SSPELNCNNEINAHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: NP_689 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 YDADMDLTASEVSKIVAVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: NP_689 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE0 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE0 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE0 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE0 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE0 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE0 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE0 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE0 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE0 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE0 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR 1210 1220 1230 1240 1250 1260 pF1KE0 DKMRR ::::: NP_689 DKMRR >>XP_005246402 (OMIM: 612425) PREDICTED: shugoshin-like (1265 aa) initn: 8145 init1: 8145 opt: 8145 Z-score: 6440.4 bits: 1203.9 E(85289): 0 Smith-Waterman score: 8145; 99.7% identity (99.9% similar) in 1265 aa overlap (1-1265:1-1265) 10 20 30 40 50 60 pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 ATEMSSLSEFHQSSFLLSASKKKRVSKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI : ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: XP_005 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 SSPELNCNNEINAHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 YDADMDLTASEVSKIVAVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: XP_005 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE0 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE0 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE0 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE0 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE0 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE0 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE0 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE0 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE0 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE0 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR 1210 1220 1230 1240 1250 1260 pF1KE0 DKMRR ::::: XP_005 DKMRR >>XP_011509036 (OMIM: 612425) PREDICTED: shugoshin-like (1265 aa) initn: 8145 init1: 8145 opt: 8145 Z-score: 6440.4 bits: 1203.9 E(85289): 0 Smith-Waterman score: 8145; 99.7% identity (99.9% similar) in 1265 aa overlap (1-1265:1-1265) 10 20 30 40 50 60 pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 ATEMSSLSEFHQSSFLLSASKKKRVSKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI : ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: XP_011 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 SSPELNCNNEINAHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 YDADMDLTASEVSKIVAVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: XP_011 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE0 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE0 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE0 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE0 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE0 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE0 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE0 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE0 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE0 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE0 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR 1210 1220 1230 1240 1250 1260 pF1KE0 DKMRR ::::: XP_011 DKMRR >>XP_005246401 (OMIM: 612425) PREDICTED: shugoshin-like (1280 aa) initn: 8145 init1: 8145 opt: 8145 Z-score: 6440.3 bits: 1203.9 E(85289): 0 Smith-Waterman score: 8145; 99.7% identity (99.9% similar) in 1265 aa overlap (1-1265:16-1280) 10 20 30 40 pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILN ::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEARRLGKEMEAWGVMECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILN 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 NSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNK 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 KLIDIEALMNNNLITATEMSSLSEFHQSSFLLSASKKKRVSKQCKLMRLPFARVPLTSND :::::::::::::::: ::::::::::::::::::::::.:::::::::::::::::::: XP_005 KLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSND 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 DEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHI 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE0 SSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE0 SADTPCATVLDKQHISSPELNCNNEINAHTNETNTEMQRNKQDLPGLSSESAREPNAECM :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: XP_005 SADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECM 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE0 NQIEDNDDFQLQKTVYDADMDLTASEVSKIVAVSTGIKKKSNKKTNEHGMKTFRKVKDSS :::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::: XP_005 NQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSS 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE0 SEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLA 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE0 QVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNS 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE0 LTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYG 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE0 THNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 THNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGN 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE0 FFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNE 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE0 SKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFE 730 740 750 760 770 780 770 780 790 800 810 820 pF1KE0 TPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQI 790 800 810 820 830 840 830 840 850 860 870 880 pF1KE0 YENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILE 850 860 870 880 890 900 890 900 910 920 930 940 pF1KE0 LKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKV 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KE0 NKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKL 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KE0 ASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEG 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KE0 ECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMV 1090 1100 1110 1120 1130 1140 1130 1140 1150 1160 1170 1180 pF1KE0 KNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQ 1150 1160 1170 1180 1190 1200 1190 1200 1210 1220 1230 1240 pF1KE0 VSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSR 1210 1220 1230 1240 1250 1260 1250 1260 pF1KE0 RRRCTPFYFKEPSLRDKMRR :::::::::::::::::::: XP_005 RRRCTPFYFKEPSLRDKMRR 1270 1280 >>XP_016858942 (OMIM: 612425) PREDICTED: shugoshin-like (1295 aa) initn: 8145 init1: 8145 opt: 8145 Z-score: 6440.2 bits: 1203.9 E(85289): 0 Smith-Waterman score: 8145; 99.7% identity (99.9% similar) in 1265 aa overlap (1-1265:31-1295) 10 20 30 pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTK :::::::::::::::::::::::::::::: XP_016 MWLHHSCLCCLLSLQMEARRLGKEMEAWGVMECPVMETGSLFTSGIKRHLKDKRISKTTK 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE0 LNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLN 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE0 FENTFLRLKLNNLNKKLIDIEALMNNNLITATEMSSLSEFHQSSFLLSASKKKRVSKQCK ::::::::::::::::::::::::::::::: ::::::::::::::::::::::.::::: XP_016 FENTFLRLKLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQCK 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 LMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLK 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE0 TERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINAHTNETNTEMQRNKQDLP ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: XP_016 TERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLP 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE0 GLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVAVSTGIKKKSNKKT ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_016 GLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKT 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE0 NEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE0 IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSS 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE0 GKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE0 ANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMY 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE0 EDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLG 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE0 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE0 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE0 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE0 DNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKD 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE0 AHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKES 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE0 SCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTT 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE0 LNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVS 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KE0 EQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNV 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KE0 IIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAE 1210 1220 1230 1240 1250 1260 1240 1250 1260 pF1KE0 SENKSEDLSSERTSRRRRCTPFYFKEPSLRDKMRR ::::::::::::::::::::::::::::::::::: XP_016 SENKSEDLSSERTSRRRRCTPFYFKEPSLRDKMRR 1270 1280 1290 >>XP_016858941 (OMIM: 612425) PREDICTED: shugoshin-like (1295 aa) initn: 8145 init1: 8145 opt: 8145 Z-score: 6440.2 bits: 1203.9 E(85289): 0 Smith-Waterman score: 8145; 99.7% identity (99.9% similar) in 1265 aa overlap (1-1265:31-1295) 10 20 30 pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTK :::::::::::::::::::::::::::::: XP_016 MWLHHSCLCCLLSLQMEARRLGKEMEAWGVMECPVMETGSLFTSGIKRHLKDKRISKTTK 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE0 LNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLN 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE0 FENTFLRLKLNNLNKKLIDIEALMNNNLITATEMSSLSEFHQSSFLLSASKKKRVSKQCK ::::::::::::::::::::::::::::::: ::::::::::::::::::::::.::::: XP_016 FENTFLRLKLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQCK 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 LMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLK 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE0 TERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINAHTNETNTEMQRNKQDLP ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: XP_016 TERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLP 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE0 GLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVAVSTGIKKKSNKKT ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_016 GLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKT 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE0 NEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE0 IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSS 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE0 GKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE0 ANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMY 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE0 EDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLG 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE0 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE0 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE0 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE0 DNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKD 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE0 AHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKES 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE0 SCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTT 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE0 LNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVS 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KE0 EQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNV 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KE0 IIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAE 1210 1220 1230 1240 1250 1260 1240 1250 1260 pF1KE0 SENKSEDLSSERTSRRRRCTPFYFKEPSLRDKMRR ::::::::::::::::::::::::::::::::::: XP_016 SENKSEDLSSERTSRRRRCTPFYFKEPSLRDKMRR 1270 1280 1290 >>NP_001153518 (OMIM: 612425) shugoshin 2 isoform 3 [Hom (1261 aa) initn: 8676 init1: 8112 opt: 8112 Z-score: 6414.3 bits: 1199.1 E(85289): 0 Smith-Waterman score: 8112; 99.6% identity (99.9% similar) in 1261 aa overlap (1-1261:1-1261) 10 20 30 40 50 60 pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 ATEMSSLSEFHQSSFLLSASKKKRVSKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI : ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: NP_001 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 SSPELNCNNEINAHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 YDADMDLTASEVSKIVAVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: NP_001 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE0 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE0 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE0 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE0 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE0 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE0 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE0 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE0 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE0 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE0 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR 1210 1220 1230 1240 1250 1260 pF1KE0 DKMRR . NP_001 E >>XP_016858943 (OMIM: 612425) PREDICTED: shugoshin-like (1291 aa) initn: 8676 init1: 8112 opt: 8112 Z-score: 6414.2 bits: 1199.1 E(85289): 0 Smith-Waterman score: 8112; 99.6% identity (99.9% similar) in 1261 aa overlap (1-1261:31-1291) 10 20 30 pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTK :::::::::::::::::::::::::::::: XP_016 MWLHHSCLCCLLSLQMEARRLGKEMEAWGVMECPVMETGSLFTSGIKRHLKDKRISKTTK 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE0 LNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLN 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE0 FENTFLRLKLNNLNKKLIDIEALMNNNLITATEMSSLSEFHQSSFLLSASKKKRVSKQCK ::::::::::::::::::::::::::::::: ::::::::::::::::::::::.::::: XP_016 FENTFLRLKLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQCK 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 LMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLK 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE0 TERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINAHTNETNTEMQRNKQDLP ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: XP_016 TERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLP 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE0 GLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVAVSTGIKKKSNKKT ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_016 GLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKT 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE0 NEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE0 IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSS 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE0 GKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE0 ANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMY 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE0 EDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLG 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE0 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE0 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE0 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE0 DNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKD 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE0 AHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKES 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE0 SCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTT 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE0 LNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVS 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KE0 EQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNV 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KE0 IIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAE 1210 1220 1230 1240 1250 1260 1240 1250 1260 pF1KE0 SENKSEDLSSERTSRRRRCTPFYFKEPSLRDKMRR ::::::::::::::::::::::::::::::. XP_016 SENKSEDLSSERTSRRRRCTPFYFKEPSLRE 1270 1280 1290 >>NP_001153505 (OMIM: 612425) shugoshin 2 isoform 2 [Hom (1260 aa) initn: 7782 init1: 7782 opt: 7782 Z-score: 6153.7 bits: 1150.8 E(85289): 0 Smith-Waterman score: 7782; 99.7% identity (99.9% similar) in 1210 aa overlap (1-1210:1-1210) 10 20 30 40 50 60 pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 ATEMSSLSEFHQSSFLLSASKKKRVSKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI : ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: NP_001 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 SSPELNCNNEINAHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 YDADMDLTASEVSKIVAVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: NP_001 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE0 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE0 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE0 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE0 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE0 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE0 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE0 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE0 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE0 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE0 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR :::::::::: NP_001 VNRRTQKSGIDHYRTCQIPVLFQITLLNLKISQKIYLQNGQAEEEGVLLSILKSQASETR 1210 1220 1230 1240 1250 1260 >>NP_001242982 (OMIM: 188000,610855) ankyrin repeat doma (1709 aa) initn: 57 init1: 57 opt: 222 Z-score: 181.5 bits: 46.2 E(85289): 0.0023 Smith-Waterman score: 259; 19.6% identity (56.2% similar) in 904 aa overlap (63-927:813-1658) 40 50 60 70 80 90 pF1KE0 VSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLNFE . : :..:. :. . :. :. .. :..: NP_001 WERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEME 790 800 810 820 830 840 100 110 120 130 pF1KE0 NTFLRLKLNNLNKKLIDIE--------ALMNNNLITATEMSSLSEFHQSSFLL------S .. .::.. .. : . : : .. : ....:. .:..... . : NP_001 LRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHS 850 860 870 880 890 900 140 150 160 170 180 190 pF1KE0 ASKKKRVSKQCKLMRLPFA--RVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQ ..: .:.. .... .: :. . . .....::: .: ...: . .. : NP_001 HEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEK-KCFEDLKI-----VKEKNEDLQ 910 920 930 940 950 200 210 220 230 240 250 pF1KE0 PLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQ . ..: :.: .:.. . . . .. .:. .....:: : .:... . NP_001 K-TIKQNEETL-----TQTISQYNGRLSVLT-AENAMLNSKLENEKQSKERLEAEVESYH 960 970 980 990 1000 260 270 280 290 300 310 pF1KE0 SIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINAHTN : : . .: .:: : : :. . ::.... .:. :::: .. . NP_001 S--RLAAAIHDRDQSETSKR--ELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQ-Q 1010 1020 1030 1040 1050 1060 320 330 340 350 360 370 pF1KE0 ETNTEMQRNKQDLPGLSSESAREPNAECMNQIE-DNDDFQLQKTVYDADMDLTASEVSKI .:: . :. .. ...: . .. ..... : .. : : .. .. .:.: NP_001 LFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKY 1070 1080 1090 1100 1110 1120 380 390 400 410 420 430 pF1KE0 VAVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVD-IGEKIENRTE .. . ..... .. .:. . .:. :.. .: .. : .. ... : .:.. ..: NP_001 IGKQESVEERLSQLQSENML--LRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESE 1130 1140 1150 1160 1170 1180 440 450 460 470 480 pF1KE0 RSDVLDGKRGAEDPGFI--FNNEQLAQMNEQLAQ---VNELKKMTLQTGFEQGDRENVLC ....: .:. : . ....: ::. . : .:.. .: .:. : : NP_001 KQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLE 1190 1200 1210 1220 1230 1240 490 500 510 520 530 540 pF1KE0 NKKEKRITNEQEETYSLSQSSGKFH---QESKFDKGQNSLTCNKSKASRQTFVIHKLEKD .. :: : ..:: .:... :... ::.. :. ... : .. ... .::::: NP_001 VTSRYRI-NLEDETQDLKKKLGQIRNQLQEAQ-DRHTEAVRCAEKMQDHK----QKLEKD 1250 1260 1270 1280 1290 550 560 570 580 590 600 pF1KE0 NLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQN- : : :::. ...: .:.. : :.:: . : :. . .. .:. NP_001 N----AKLKVTVKKQMDKIEELQKNLL----NANLSE-------DEKEQLKKLMELKQSL 1300 1310 1320 1330 1340 610 620 630 640 650 660 pF1KE0 ESNINK-LRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVS : :... ..:.:. . :: .:.... . . : . . ..:.: :. . . .:... NP_001 ECNLDQEMKKNVELEREI-TGFKNLLKMTRKKL-NEYENGEFSFHGDLKTSQFEMDIQIN 1350 1360 1370 1380 1390 670 680 690 700 710 720 pF1KE0 K-ELQIPALSTRDNE--NQCDY-RTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT : . .: :... . ..: . :.: . ::... .: ::.. :..:. ..:... NP_001 KLKHKIDDLTAELETAGSKCLHLDTKNQI-LQEELLSMKTVQKKCEKLQKN-KKKLEQ-- 1400 1410 1420 1430 1440 1450 730 740 750 760 770 780 pF1KE0 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS :.:. .:.. . ::... . .. .. : .:.. . : .... :: . NP_001 EVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQE--NLEQF 1460 1470 1480 1490 1500 1510 790 800 810 820 830 pF1KE0 EIQNVLGVKHGHDMQPACQNDSKIGK-KPRLNVCQKSEIIPETNQIYENDNKGVHDLE-- . .: ..: ... . .:...: : . .:.:. . .:.: .. : ..: NP_001 RENNFASMKSQMELRIK-DLESELSKIKTSQEDFNKTEL-EKYKQLYLEELKVRKSLSSK 1520 1530 1540 1550 1560 1570 840 850 860 870 880 890 pF1KE0 --KDNFFSLTPKDKETISENLQVTNEFQTVDL--LIKDNGNLCDYDTQNILELKKYVTDR : : :. . . . :. : . : :. ... : . .: :.:.. . : NP_001 LTKTNE-RLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPP---CVGNLNNSLDLNRKLIPR 1580 1590 1600 1610 1620 900 910 920 930 940 950 pF1KE0 KSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLE .. . :. : . : . .:.:.: : : NP_001 ENLVISTSNP---RASNNSMENYLSKMQQELEKNITRELKEAAAELESGSIASPLGSTDE 1630 1640 1650 1660 1670 1680 960 970 980 990 1000 1010 pF1KE0 CQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESS NP_001 SNLNQDLVWKASREYVQVLKKNYMI 1690 1700 1265 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 16:18:05 2016 done: Thu Nov 3 16:18:06 2016 Total Scan time: 11.590 Total Display time: 0.630 Function used was FASTA [36.3.4 Apr, 2011]