Result of FASTA (omim) for pF1KE2019
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE2019, 596 aa
  1>>>pF1KE2019     596 - 596 aa - 596 aa
Library: /omim/omim.rfq.tfa
  64092750 residues in 91774 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.2055+/-0.00037; mu= 20.4205+/- 0.023
 mean_var=83.2171+/-16.596, 0's: 0 Z-trim(113.4): 53  B-trim: 45 in 1/54
 Lambda= 0.140594
 statistics sampled from 23523 (23572) to 23523 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.623), E-opt: 0.2 (0.257), width:  16
 Scan time:  5.180

The best scores are:                                      opt bits E(91774)
XP_016869077 (OMIM: 605993,608782) pyruvate dehyro ( 591) 3825 786.2       0
NP_001155251 (OMIM: 605993,608782) pyruvate dehyro ( 562) 3818 784.7       0
NP_001155252 (OMIM: 605993,608782) pyruvate dehyro ( 562) 3818 784.7       0
XP_011515437 (OMIM: 605993,608782) pyruvate dehyro ( 555) 3725 765.9       0
NP_060914 (OMIM: 605993,608782) pyruvate dehyrogen ( 537) 3637 748.0  2e-215
NP_001155253 (OMIM: 605993,608782) pyruvate dehyro ( 537) 3637 748.0  2e-215
XP_011515438 (OMIM: 605993,608782) pyruvate dehyro ( 537) 3637 748.0  2e-215
NP_001316862 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_001316863 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_065837 (OMIM: 615499) [Pyruvate dehydrogenase [ ( 529) 1715 358.2 4.4e-98
NP_001316860 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_001316859 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_001316858 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_001316861 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_001316857 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_003611 (OMIM: 114480,605100,617450) protein pho ( 605)  213 53.6 2.5e-06


>>XP_016869077 (OMIM: 605993,608782) pyruvate dehyrogena  (591 aa)
 initn: 3825 init1: 3825 opt: 3825  Z-score: 4194.8  bits: 786.2 E(91774):    0
Smith-Waterman score: 3825; 100.0% identity (100.0% similar) in 563 aa overlap (34-596:29-591)

            10        20        30        40        50        60   
pF1KE2 SALLSMGRCCCRCCCPRGLWMLSAPCCDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAP
                                     ::::::::::::::::::::::::::::::
XP_016   MEGLALGAHPCSRLGPAALGCGFASPAGRMCVCPGPRRIGIPVRSSSLPLFSDAMPAP
                 10        20        30        40        50        

            70        80        90       100       110       120   
pF1KE2 TQLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQ
       60        70        80        90       100       110        

           130       140       150       160       170       180   
pF1KE2 YTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIE
      120       130       140       150       160       170        

           190       200       210       220       230       240   
pF1KE2 DRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGR
      180       190       200       210       220       230        

           250       260       270       280       290       300   
pF1KE2 ALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLD
      240       250       260       270       280       290        

           310       320       330       340       350       360   
pF1KE2 NDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGS
      300       310       320       330       340       350        

           370       380       390       400       410       420   
pF1KE2 WSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDL
      360       370       380       390       400       410        

           430       440       450       460       470       480   
pF1KE2 QKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETM
      420       430       440       450       460       470        

           490       500       510       520       530       540   
pF1KE2 HRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIR
      480       490       500       510       520       530        

           550       560       570       580       590      
pF1KE2 HAVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
       :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
      540       550       560       570       580       590 

>>NP_001155251 (OMIM: 605993,608782) pyruvate dehyrogena  (562 aa)
 initn: 3818 init1: 3818 opt: 3818  Z-score: 4187.4  bits: 784.7 E(91774):    0
Smith-Waterman score: 3818; 100.0% identity (100.0% similar) in 562 aa overlap (35-596:1-562)

           10        20        30        40        50        60    
pF1KE2 ALLSMGRCCCRCCCPRGLWMLSAPCCDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAPT
                                     ::::::::::::::::::::::::::::::
NP_001                               MCVCPGPRRIGIPVRSSSLPLFSDAMPAPT
                                             10        20        30

           70        80        90       100       110       120    
pF1KE2 QLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQY
               40        50        60        70        80        90

          130       140       150       160       170       180    
pF1KE2 TQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIED
              100       110       120       130       140       150

          190       200       210       220       230       240    
pF1KE2 RRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRA
              160       170       180       190       200       210

          250       260       270       280       290       300    
pF1KE2 LLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDN
              220       230       240       250       260       270

          310       320       330       340       350       360    
pF1KE2 DISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSW
              280       290       300       310       320       330

          370       380       390       400       410       420    
pF1KE2 SAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQ
              340       350       360       370       380       390

          430       440       450       460       470       480    
pF1KE2 KRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMH
              400       410       420       430       440       450

          490       500       510       520       530       540    
pF1KE2 RQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRH
              460       470       480       490       500       510

          550       560       570       580       590      
pF1KE2 AVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
              520       530       540       550       560  

>>NP_001155252 (OMIM: 605993,608782) pyruvate dehyrogena  (562 aa)
 initn: 3818 init1: 3818 opt: 3818  Z-score: 4187.4  bits: 784.7 E(91774):    0
Smith-Waterman score: 3818; 100.0% identity (100.0% similar) in 562 aa overlap (35-596:1-562)

           10        20        30        40        50        60    
pF1KE2 ALLSMGRCCCRCCCPRGLWMLSAPCCDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAPT
                                     ::::::::::::::::::::::::::::::
NP_001                               MCVCPGPRRIGIPVRSSSLPLFSDAMPAPT
                                             10        20        30

           70        80        90       100       110       120    
pF1KE2 QLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQY
               40        50        60        70        80        90

          130       140       150       160       170       180    
pF1KE2 TQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIED
              100       110       120       130       140       150

          190       200       210       220       230       240    
pF1KE2 RRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRA
              160       170       180       190       200       210

          250       260       270       280       290       300    
pF1KE2 LLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDN
              220       230       240       250       260       270

          310       320       330       340       350       360    
pF1KE2 DISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSW
              280       290       300       310       320       330

          370       380       390       400       410       420    
pF1KE2 SAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQ
              340       350       360       370       380       390

          430       440       450       460       470       480    
pF1KE2 KRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMH
              400       410       420       430       440       450

          490       500       510       520       530       540    
pF1KE2 RQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRH
              460       470       480       490       500       510

          550       560       570       580       590      
pF1KE2 AVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
              520       530       540       550       560  

>>XP_011515437 (OMIM: 605993,608782) pyruvate dehyrogena  (555 aa)
 initn: 3725 init1: 3725 opt: 3725  Z-score: 4085.5  bits: 765.9 E(91774):    0
Smith-Waterman score: 3725; 100.0% identity (100.0% similar) in 551 aa overlap (46-596:5-555)

          20        30        40        50        60        70     
pF1KE2 CCCPRGLWMLSAPCCDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAPTQLFFPLIRNCE
                                     ::::::::::::::::::::::::::::::
XP_011                           MFERIPVRSSSLPLFSDAMPAPTQLFFPLIRNCE
                                         10        20        30    

          80        90       100       110       120       130     
pF1KE2 LSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQ
           40        50        60        70        80        90    

         140       150       160       170       180       190     
pF1KE2 KFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTR
          100       110       120       130       140       150    

         200       210       220       230       240       250     
pF1KE2 GMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHP
          160       170       180       190       200       210    

         260       270       280       290       300       310     
pF1KE2 NDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDP
          220       230       240       250       260       270    

         320       330       340       350       360       370     
pF1KE2 NSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNA
          280       290       300       310       320       330    

         380       390       400       410       420       430     
pF1KE2 QNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQL
          340       350       360       370       380       390    

         440       450       460       470       480       490     
pF1KE2 NDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEY
          400       410       420       430       440       450    

         500       510       520       530       540       550     
pF1KE2 LTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVD
          460       470       480       490       500       510    

         560       570       580       590      
pF1KE2 HERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
       :::::::::::::::::::::::::::::::::::::::::
XP_011 HERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
          520       530       540       550     

>>NP_060914 (OMIM: 605993,608782) pyruvate dehyrogenase   (537 aa)
 initn: 3637 init1: 3637 opt: 3637  Z-score: 3989.3  bits: 748.0 E(91774): 2e-215
Smith-Waterman score: 3637; 100.0% identity (100.0% similar) in 537 aa overlap (60-596:1-537)

      30        40        50        60        70        80         
pF1KE2 CDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAPTQLFFPLIRNCELSRIYGTACYCHHK
                                     ::::::::::::::::::::::::::::::
NP_060                               MPAPTQLFFPLIRNCELSRIYGTACYCHHK
                                             10        20        30

      90       100       110       120       130       140         
pF1KE2 HLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILK
               40        50        60        70        80        90

     150       160       170       180       190       200         
pF1KE2 ANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCA
              100       110       120       130       140       150

     210       220       230       240       250       260         
pF1KE2 CSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 CSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFN
              160       170       180       190       200       210

     270       280       290       300       310       320         
pF1KE2 SLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFS
              220       230       240       250       260       270

     330       340       350       360       370       380         
pF1KE2 GATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHP
              280       290       300       310       320       330

     390       400       410       420       430       440         
pF1KE2 KSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYH
              340       350       360       370       380       390

     450       460       470       480       490       500         
pF1KE2 TPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 TPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGG
              400       410       420       430       440       450

     510       520       530       540       550       560         
pF1KE2 YKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 YKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEEL
              460       470       480       490       500       510

     570       580       590      
pF1KE2 ARMYRDDITIIVVQFNSHVVGAYQNQE
       :::::::::::::::::::::::::::
NP_060 ARMYRDDITIIVVQFNSHVVGAYQNQE
              520       530       

>>NP_001155253 (OMIM: 605993,608782) pyruvate dehyrogena  (537 aa)
 initn: 3637 init1: 3637 opt: 3637  Z-score: 3989.3  bits: 748.0 E(91774): 2e-215
Smith-Waterman score: 3637; 100.0% identity (100.0% similar) in 537 aa overlap (60-596:1-537)

      30        40        50        60        70        80         
pF1KE2 CDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAPTQLFFPLIRNCELSRIYGTACYCHHK
                                     ::::::::::::::::::::::::::::::
NP_001                               MPAPTQLFFPLIRNCELSRIYGTACYCHHK
                                             10        20        30

      90       100       110       120       130       140         
pF1KE2 HLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILK
               40        50        60        70        80        90

     150       160       170       180       190       200         
pF1KE2 ANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCA
              100       110       120       130       140       150

     210       220       230       240       250       260         
pF1KE2 CSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFN
              160       170       180       190       200       210

     270       280       290       300       310       320         
pF1KE2 SLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFS
              220       230       240       250       260       270

     330       340       350       360       370       380         
pF1KE2 GATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHP
              280       290       300       310       320       330

     390       400       410       420       430       440         
pF1KE2 KSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYH
              340       350       360       370       380       390

     450       460       470       480       490       500         
pF1KE2 TPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGG
              400       410       420       430       440       450

     510       520       530       540       550       560         
pF1KE2 YKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEEL
              460       470       480       490       500       510

     570       580       590      
pF1KE2 ARMYRDDITIIVVQFNSHVVGAYQNQE
       :::::::::::::::::::::::::::
NP_001 ARMYRDDITIIVVQFNSHVVGAYQNQE
              520       530       

>>XP_011515438 (OMIM: 605993,608782) pyruvate dehyrogena  (537 aa)
 initn: 3637 init1: 3637 opt: 3637  Z-score: 3989.3  bits: 748.0 E(91774): 2e-215
Smith-Waterman score: 3637; 100.0% identity (100.0% similar) in 537 aa overlap (60-596:1-537)

      30        40        50        60        70        80         
pF1KE2 CDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAPTQLFFPLIRNCELSRIYGTACYCHHK
                                     ::::::::::::::::::::::::::::::
XP_011                               MPAPTQLFFPLIRNCELSRIYGTACYCHHK
                                             10        20        30

      90       100       110       120       130       140         
pF1KE2 HLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILK
               40        50        60        70        80        90

     150       160       170       180       190       200         
pF1KE2 ANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCA
              100       110       120       130       140       150

     210       220       230       240       250       260         
pF1KE2 CSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFN
              160       170       180       190       200       210

     270       280       290       300       310       320         
pF1KE2 SLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFS
              220       230       240       250       260       270

     330       340       350       360       370       380         
pF1KE2 GATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHP
              280       290       300       310       320       330

     390       400       410       420       430       440         
pF1KE2 KSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYH
              340       350       360       370       380       390

     450       460       470       480       490       500         
pF1KE2 TPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGG
              400       410       420       430       440       450

     510       520       530       540       550       560         
pF1KE2 YKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEEL
              460       470       480       490       500       510

     570       580       590      
pF1KE2 ARMYRDDITIIVVQFNSHVVGAYQNQE
       :::::::::::::::::::::::::::
XP_011 ARMYRDDITIIVVQFNSHVVGAYQNQE
              520       530       

>>NP_001316862 (OMIM: 615499) [Pyruvate dehydrogenase [a  (529 aa)
 initn: 1357 init1: 586 opt: 1715  Z-score: 1882.4  bits: 358.2 E(91774): 4.4e-98
Smith-Waterman score: 1715; 54.4% identity (79.9% similar) in 472 aa overlap (126-592:61-525)

         100       110       120       130          140       150  
pF1KE2 SYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQ---KFYLTPPQVNSILKANE
                                     .. :..:: .   .. :.: :.: .:.:.:
NP_001 VSNRNKLKWRLFSRVPPTLNSSPCGGFTLCKAYRHTSTEEDDFHLQLSPEQINEVLRAGE
               40        50        60        70        80        90

            160       170       180       190       200       210  
pF1KE2 YSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQ
        . :. .....  .:.: :.:::: ::.:.::::..:.:::: :...:.::::.: ::.:
NP_001 TTHKILDLESRVPNSVLRFESNQLAANSPVEDRRGVASCLQTNGLMFGIFDGHGGHACAQ
              100       110       120       130       140       150

            220       230       240       250       260       270  
pF1KE2 AVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLR
       :::::::::.::::. :.:: ..:.:.:: . :::::.: :::.: . :........ ::
NP_001 AVSERLFYYVAVSLMSHQTLEHMEGAMESMKPLLPILHWLKHPGDSIYKDVTSVHLDHLR
              160       170       180       190       200       210

            280       290       300       310       320       330  
pF1KE2 TYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGAT
       .:::::.::.      ....:::. .:.:::.::::: :.   .     : :.:::::::
NP_001 VYWQELLDLHM--EMGLSIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGAT
              220         230       240       250       260        

            340       350       360       370       380       390  
pF1KE2 ACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSE
       ::.:::::. :::::.:: ::.:::::..: :: . :. :::: :. :: ::: :::.::
NP_001 ACMAHVDGIHLHVANAGDCRAILGVQEDNGMWSCLPLTRDHNAWNQAELSRLKREHPESE
      270       280       290       300       310       320        

            400       410       420       430       440       450  
pF1KE2 AKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPP
        .... .:::::.:.: ::::::..::: .::. ..: : .    : : .: ::.:.:::
NP_001 DRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNIY-QFTPPHYYTPP
      330       340       350       360       370        380       

            460       470       480       490        500       510 
pF1KE2 YLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVR-IVGEYLTGMHHQQPIAVGGYK
       :::::::::::::::::::::::.::::. .  .:::: .::.   .  :.  .:     
NP_001 YLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAEADWHKTDLA--QRP
       390       400       410       420       430       440       

             520       530        540       550       560       570
pF1KE2 VTLGQMHGLLTERRTKMSSVFE-DQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEELA
       ..:: :..:: .:  : :.. : ::::::.:::::.::::.: .. :::. ::.:::.::
NP_001 ANLGLMQSLLLQR--KASGLHEADQNAATRLIRHAIGNNEYGEMEAERLAAMLTLPEDLA
         450         460       470       480       490       500   

              580       590      
pF1KE2 RMYRDDITIIVVQFNSHVVGAYQNQE
       ::::::::. :: :::. .:::    
NP_001 RMYRDDITVTVVYFNSESIGAYYKGG
           510       520         

>>NP_001316863 (OMIM: 615499) [Pyruvate dehydrogenase [a  (529 aa)
 initn: 1357 init1: 586 opt: 1715  Z-score: 1882.4  bits: 358.2 E(91774): 4.4e-98
Smith-Waterman score: 1715; 54.4% identity (79.9% similar) in 472 aa overlap (126-592:61-525)

         100       110       120       130          140       150  
pF1KE2 SYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQ---KFYLTPPQVNSILKANE
                                     .. :..:: .   .. :.: :.: .:.:.:
NP_001 VSNRNKLKWRLFSRVPPTLNSSPCGGFTLCKAYRHTSTEEDDFHLQLSPEQINEVLRAGE
               40        50        60        70        80        90

            160       170       180       190       200       210  
pF1KE2 YSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQ
        . :. .....  .:.: :.:::: ::.:.::::..:.:::: :...:.::::.: ::.:
NP_001 TTHKILDLESRVPNSVLRFESNQLAANSPVEDRRGVASCLQTNGLMFGIFDGHGGHACAQ
              100       110       120       130       140       150

            220       230       240       250       260       270  
pF1KE2 AVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLR
       :::::::::.::::. :.:: ..:.:.:: . :::::.: :::.: . :........ ::
NP_001 AVSERLFYYVAVSLMSHQTLEHMEGAMESMKPLLPILHWLKHPGDSIYKDVTSVHLDHLR
              160       170       180       190       200       210

            280       290       300       310       320       330  
pF1KE2 TYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGAT
       .:::::.::.      ....:::. .:.:::.::::: :.   .     : :.:::::::
NP_001 VYWQELLDLHM--EMGLSIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGAT
              220         230       240       250       260        

            340       350       360       370       380       390  
pF1KE2 ACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSE
       ::.:::::. :::::.:: ::.:::::..: :: . :. :::: :. :: ::: :::.::
NP_001 ACMAHVDGIHLHVANAGDCRAILGVQEDNGMWSCLPLTRDHNAWNQAELSRLKREHPESE
      270       280       290       300       310       320        

            400       410       420       430       440       450  
pF1KE2 AKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPP
        .... .:::::.:.: ::::::..::: .::. ..: : .    : : .: ::.:.:::
NP_001 DRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNIY-QFTPPHYYTPP
      330       340       350       360       370        380       

            460       470       480       490        500       510 
pF1KE2 YLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVR-IVGEYLTGMHHQQPIAVGGYK
       :::::::::::::::::::::::.::::. .  .:::: .::.   .  :.  .:     
NP_001 YLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAEADWHKTDLA--QRP
       390       400       410       420       430       440       

             520       530        540       550       560       570
pF1KE2 VTLGQMHGLLTERRTKMSSVFE-DQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEELA
       ..:: :..:: .:  : :.. : ::::::.:::::.::::.: .. :::. ::.:::.::
NP_001 ANLGLMQSLLLQR--KASGLHEADQNAATRLIRHAIGNNEYGEMEAERLAAMLTLPEDLA
         450         460       470       480       490       500   

              580       590      
pF1KE2 RMYRDDITIIVVQFNSHVVGAYQNQE
       ::::::::. :: :::. .:::    
NP_001 RMYRDDITVTVVYFNSESIGAYYKGG
           510       520         

>>NP_065837 (OMIM: 615499) [Pyruvate dehydrogenase [acet  (529 aa)
 initn: 1357 init1: 586 opt: 1715  Z-score: 1882.4  bits: 358.2 E(91774): 4.4e-98
Smith-Waterman score: 1715; 54.4% identity (79.9% similar) in 472 aa overlap (126-592:61-525)

         100       110       120       130          140       150  
pF1KE2 SYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQ---KFYLTPPQVNSILKANE
                                     .. :..:: .   .. :.: :.: .:.:.:
NP_065 VSNRNKLKWRLFSRVPPTLNSSPCGGFTLCKAYRHTSTEEDDFHLQLSPEQINEVLRAGE
               40        50        60        70        80        90

            160       170       180       190       200       210  
pF1KE2 YSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQ
        . :. .....  .:.: :.:::: ::.:.::::..:.:::: :...:.::::.: ::.:
NP_065 TTHKILDLESRVPNSVLRFESNQLAANSPVEDRRGVASCLQTNGLMFGIFDGHGGHACAQ
              100       110       120       130       140       150

            220       230       240       250       260       270  
pF1KE2 AVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLR
       :::::::::.::::. :.:: ..:.:.:: . :::::.: :::.: . :........ ::
NP_065 AVSERLFYYVAVSLMSHQTLEHMEGAMESMKPLLPILHWLKHPGDSIYKDVTSVHLDHLR
              160       170       180       190       200       210

            280       290       300       310       320       330  
pF1KE2 TYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGAT
       .:::::.::.      ....:::. .:.:::.::::: :.   .     : :.:::::::
NP_065 VYWQELLDLHM--EMGLSIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGAT
              220         230       240       250       260        

            340       350       360       370       380       390  
pF1KE2 ACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSE
       ::.:::::. :::::.:: ::.:::::..: :: . :. :::: :. :: ::: :::.::
NP_065 ACMAHVDGIHLHVANAGDCRAILGVQEDNGMWSCLPLTRDHNAWNQAELSRLKREHPESE
      270       280       290       300       310       320        

            400       410       420       430       440       450  
pF1KE2 AKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPP
        .... .:::::.:.: ::::::..::: .::. ..: : .    : : .: ::.:.:::
NP_065 DRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNIY-QFTPPHYYTPP
      330       340       350       360       370        380       

            460       470       480       490        500       510 
pF1KE2 YLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVR-IVGEYLTGMHHQQPIAVGGYK
       :::::::::::::::::::::::.::::. .  .:::: .::.   .  :.  .:     
NP_065 YLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAEADWHKTDLA--QRP
       390       400       410       420       430       440       

             520       530        540       550       560       570
pF1KE2 VTLGQMHGLLTERRTKMSSVFE-DQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEELA
       ..:: :..:: .:  : :.. : ::::::.:::::.::::.: .. :::. ::.:::.::
NP_065 ANLGLMQSLLLQR--KASGLHEADQNAATRLIRHAIGNNEYGEMEAERLAAMLTLPEDLA
         450         460       470       480       490       500   

              580       590      
pF1KE2 RMYRDDITIIVVQFNSHVVGAYQNQE
       ::::::::. :: :::. .:::    
NP_065 RMYRDDITVTVVYFNSESIGAYYKGG
           510       520         




596 residues in 1 query   sequences
64092750 residues in 91774 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Tue Jul 16 15:42:44 2019 done: Tue Jul 16 15:42:45 2019
 Total Scan time:  5.180 Total Display time:  0.110

Function used was FASTA [36.3.4 Apr, 2011]
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