FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2751, 272 aa 1>>>pF1KE2751 272 - 272 aa - 272 aa Library: human.CCDS.faa 18921897 residues in 33420 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1277+/-0.000901; mu= 8.5637+/- 0.054 mean_var=173.1605+/-32.344, 0's: 0 Z-trim(113.0): 35 B-trim: 52 in 1/49 Lambda= 0.097465 statistics sampled from 13876 (13906) to 13876 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.754), E-opt: 0.2 (0.416), width: 16 Scan time: 1.150 The best scores are: opt bits E(33420) CCDS5135.1 RSPO3 gene_id:84870|Hs109|chr6 ( 272) 1951 285.8 2.3e-77 CCDS41304.1 RSPO1 gene_id:284654|Hs109|chr1 ( 263) 885 135.9 3e-32 CCDS55591.1 RSPO1 gene_id:284654|Hs109|chr1 ( 236) 842 129.8 1.8e-30 CCDS6307.1 RSPO2 gene_id:340419|Hs109|chr8 ( 243) 825 127.4 9.8e-30 CCDS42846.1 RSPO4 gene_id:343637|Hs109|chr20 ( 234) 667 105.2 4.7e-23 CCDS83314.1 RSPO2 gene_id:340419|Hs109|chr8 ( 176) 645 102.0 3.3e-22 CCDS55590.1 RSPO1 gene_id:284654|Hs109|chr1 ( 200) 565 90.8 8.7e-19 CCDS64953.1 RSPO2 gene_id:340419|Hs109|chr8 ( 179) 494 80.7 8.1e-16 CCDS42845.1 RSPO4 gene_id:343637|Hs109|chr20 ( 172) 448 74.2 7e-14 >>CCDS5135.1 RSPO3 gene_id:84870|Hs109|chr6 (272 aa) initn: 1951 init1: 1951 opt: 1951 Z-score: 1502.6 bits: 285.8 E(33420): 2.3e-77 Smith-Waterman score: 1951; 100.0% identity (100.0% similar) in 272 aa overlap (1-272:1-272) 10 20 30 40 50 60 pF1KE2 MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS51 MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS51 LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS51 HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS51 QHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLES 190 200 210 220 230 240 250 260 270 pF1KE2 SKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH :::::::::::::::::::::::::::::::: CCDS51 SKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH 250 260 270 >>CCDS41304.1 RSPO1 gene_id:284654|Hs109|chr1 (263 aa) initn: 881 init1: 508 opt: 885 Z-score: 692.7 bits: 135.9 E(33420): 3e-32 Smith-Waterman score: 885; 46.0% identity (72.2% similar) in 252 aa overlap (11-257:10-251) 10 20 30 40 50 60 pF1KE2 MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR ..:.. . :. . .:.::::. . ::.: :: ::. ::::.:.:. CCDS41 MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPK 10 20 30 40 50 70 80 90 100 110 pF1KE2 LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKAD-CDTCFNKNFCTKCKSGFY ::. ::: ..:.:::: ::: ::. .: ::.::: ::: . :..::..::::::: :.: CCDS41 LFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLY 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 LHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREI :: :.: :::: : : :::: : ..::.:::.::.::.:: . :::.::.: :.:.. CCDS41 LHKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 IQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKG----ESKEAIPDS .. : . : :.:::.:::.: : .:.. .:: . .:.. :.. ::::: : CCDS41 LHAPVGDHAACSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLARKESKEAGAGS 180 190 200 210 220 230 240 250 260 270 pF1KE2 KSLESSKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH . .:...:::... CCDS41 R----------RRKGQQQQQQQGTVGPLTSAGPA 240 250 260 >>CCDS55591.1 RSPO1 gene_id:284654|Hs109|chr1 (236 aa) initn: 857 init1: 508 opt: 842 Z-score: 660.6 bits: 129.8 E(33420): 1.8e-30 Smith-Waterman score: 842; 47.6% identity (72.3% similar) in 231 aa overlap (32-257:4-224) 10 20 30 40 50 60 pF1KE2 HLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRL :. . ::.: :: ::. ::::.:.:.: CCDS55 MIFRVSAEGSQACAKGCELCSEVNGCLKCSPKL 10 20 30 70 80 90 100 110 120 pF1KE2 FFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKAD-CDTCFNKNFCTKCKSGFYL :. ::: ..:.:::: ::: ::. .: ::.::: ::: . :..::..::::::: :.:: CCDS55 FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII : :.: :::: : : :::: : ..::.:::.::.::.:: . :::.::.: :.:... CCDS55 HKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVL 100 110 120 130 140 150 190 200 210 220 230 pF1KE2 QHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKG----ESKEAIPDSK . : . : :.:::.:::.: : .:.. .:: . .:.. :.. ::::: :. CCDS55 HAPVGDHAACSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLARKESKEAGAGSR 160 170 180 190 200 210 240 250 260 270 pF1KE2 SLESSKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH .:...:::... CCDS55 ----------RRKGQQQQQQQGTVGPLTSAGPA 220 230 >>CCDS6307.1 RSPO2 gene_id:340419|Hs109|chr8 (243 aa) initn: 598 init1: 280 opt: 825 Z-score: 647.5 bits: 127.4 E(33420): 9.8e-30 Smith-Waterman score: 825; 47.3% identity (73.5% similar) in 226 aa overlap (1-225:1-222) 10 20 30 40 50 60 pF1KE2 MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR :..::.:. .:::: :.: :. .: ::..: . :.: : .:: ::: :. . CCDS63 MQFRLFSFALIILNCMDYSHCQG-NRWRRSKRASYVSNPICKG-CLSCSKDNGCSRCQQK 10 20 30 40 50 70 80 90 100 110 pF1KE2 LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKAD-CDTCFNKNFCTKCKSGFY ::: :.: ::.: : :: :::::::: : ::.:.:..:. . ::.::.:.:::::: ::: CCDS63 LFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFY 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 LHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREI :: :.:.:.::.:. ..::::: :::..:. :. :.....::::: : :::.:.: CCDS63 LHRGRCFDECPDGFAPLEETMECVE--GCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 IQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLE ...: ::: :.:.: . ..: :.: :..:.. :: .. CCDS63 VKKPVKDTILCPTIAESRRCKMTMRHCPGGKRTPKAKEKRNKKKKRKLIERAQEQHSVFL 180 190 200 210 220 230 240 250 260 270 pF1KE2 SSKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH CCDS63 ATDRANQ 240 >>CCDS42846.1 RSPO4 gene_id:343637|Hs109|chr20 (234 aa) initn: 619 init1: 431 opt: 667 Z-score: 527.7 bits: 105.2 E(33420): 4.7e-23 Smith-Waterman score: 667; 43.3% identity (69.2% similar) in 201 aa overlap (28-225:22-217) 10 20 30 40 50 60 pF1KE2 MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR ::.... ... .: : : ::. ::: .:. : CCDS42 MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTG-CIICSEENGCSTCQQR 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL ::. ..: :..: : :: .:: ::.: : ..:.: :: : :..::...:: .:: ::: CCDS42 LFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII . :::: .:: : :...: :: . .::.. :. :::::..::::: : :.:::: CCDS42 YKGKCLPTCPPGTLAHQNTRECQG--ECELGPWGGWSPCTHNGKTCGSAWGLESRVREAG 120 130 140 150 160 170 190 200 210 220 230 pF1KE2 QHPSAKGNLCPPTNETRKCTVQRKKCQKGERG---KKGRERKRKKPNKGESKEAIPDSKS . .. : .:.::: .:: : :::. ::::. .: . .. CCDS42 RAGHEEAATCQVLSESRKCPIQRP-CP-GERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQ 180 190 200 210 220 240 250 260 270 pF1KE2 LESSKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH CCDS42 PGLQP 230 >>CCDS83314.1 RSPO2 gene_id:340419|Hs109|chr8 (176 aa) initn: 549 init1: 270 opt: 645 Z-score: 512.5 bits: 102.0 E(33420): 3.3e-22 Smith-Waterman score: 645; 49.0% identity (76.4% similar) in 157 aa overlap (70-225:1-155) 40 50 60 70 80 90 pF1KE2 GCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCK :.: : :: :::::::: : ::.:.:..:. CCDS83 MRQYGECLHSCPSGYYGHRAPDMNRCARCR 10 20 30 100 110 120 130 140 150 pF1KE2 AD-CDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSP . ::.::.:.:::::: ::::: :.:.:.::.:. ..::::: :::..:. :. CCDS83 IENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVE--GCEVGHWSEWGT 40 50 60 70 80 160 170 180 190 200 210 pF1KE2 CTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRER :.....::::: : :::.:.:...: ::: :.:.: . ..: :.: :..:. CCDS83 CSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCKMTMRHCPGGKRTPKAKEK 90 100 110 120 130 140 220 230 240 250 260 270 pF1KE2 KRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH . :: .. CCDS83 RNKKKKRKLIERAQEQHSVFLATDRANQ 150 160 170 >>CCDS55590.1 RSPO1 gene_id:284654|Hs109|chr1 (200 aa) initn: 572 init1: 336 opt: 565 Z-score: 451.0 bits: 90.8 E(33420): 8.7e-19 Smith-Waterman score: 565; 52.6% identity (74.8% similar) in 135 aa overlap (11-144:10-144) 10 20 30 40 50 60 pF1KE2 MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR ..:.. . :. . .:.::::. . ::.: :: ::. ::::.:.:. CCDS55 MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPK 10 20 30 40 50 70 80 90 100 110 pF1KE2 LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKAD-CDTCFNKNFCTKCKSGFY ::. ::: ..:.:::: ::: ::. .: ::.::: ::: . :..::..::::::: :.: CCDS55 LFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLY 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 LHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREI :: :.: :::: : : :::: : CCDS55 LHKGRCYPACPEGSSAANGTMECSSPGQKRRKGGQGRRENANRNLARKESKEAGAGSRRR 120 130 140 150 160 170 >>CCDS64953.1 RSPO2 gene_id:340419|Hs109|chr8 (179 aa) initn: 600 init1: 270 opt: 494 Z-score: 397.6 bits: 80.7 E(33420): 8.1e-16 Smith-Waterman score: 494; 45.7% identity (76.0% similar) in 129 aa overlap (98-225:33-158) 70 80 90 100 110 120 pF1KE2 IGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKAD-CDTCFNKNFCTKCKSGFYLHLGKCL :. . ::.::.:.:::::: ::::: :.:. CCDS64 FRLFSFALIILNCMDYSHCQGNRWRRSKRGCRIENCDSCFSKDFCTKCKVGFYLHRGRCF 10 20 30 40 50 60 130 140 150 160 170 180 pF1KE2 DNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAK :.::.:. ..:::::. :::..:. :. :.....::::: : :::.:.:...: CCDS64 DECPDGFAPLEETMECVG---CEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKD 70 80 90 100 110 190 200 210 220 230 240 pF1KE2 GNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPE ::: :.:.: . ..: :.: :..:.. :: .. CCDS64 TILCPTIAESRRCKMTMRHCPGGKRTPKAKEKRNKKKKRKLIERAQEQHSVFLATDRANQ 120 130 140 150 160 170 250 260 270 pF1KE2 QRENKQQQKKRKVQDKQKSVSVSTVH >>CCDS42845.1 RSPO4 gene_id:343637|Hs109|chr20 (172 aa) initn: 451 init1: 431 opt: 448 Z-score: 362.9 bits: 74.2 E(33420): 7e-14 Smith-Waterman score: 448; 45.2% identity (73.0% similar) in 115 aa overlap (28-142:22-135) 10 20 30 40 50 60 pF1KE2 MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR ::.... ... .: : : ::. ::: .:. : CCDS42 MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTG-CIICSEENGCSTCQQR 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL ::. ..: :..: : :: .:: ::.: : ..:.: :: : :..::...:: .:: ::: CCDS42 LFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII . :::: .:: : :...: :: CCDS42 YKGKCLPTCPPGTLAHQNTRECQERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP 120 130 140 150 160 170 272 residues in 1 query sequences 18921897 residues in 33420 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Jun 30 14:57:09 2019 done: Sun Jun 30 14:57:09 2019 Total Scan time: 1.150 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]