FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1062, 1454 aa 1>>>pF1KE1062 1454 - 1454 aa - 1454 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.4234+/-0.000566; mu= -11.3296+/- 0.035 mean_var=447.5221+/-96.140, 0's: 0 Z-trim(118.4): 515 B-trim: 476 in 2/56 Lambda= 0.060627 statistics sampled from 30763 (31382) to 30763 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.368), width: 16 Scan time: 19.480 The best scores are: opt bits E(85289) XP_016877721 (OMIM: 601907) PREDICTED: neogenin is (1454) 9689 863.8 0 XP_016877724 (OMIM: 601907) PREDICTED: neogenin is (1401) 8261 738.9 6.4e-212 XP_011519934 (OMIM: 601907) PREDICTED: neogenin is (1447) 8119 726.5 3.6e-208 XP_011519932 (OMIM: 601907) PREDICTED: neogenin is (1465) 7064 634.2 2.2e-180 XP_016877723 (OMIM: 601907) PREDICTED: neogenin is (1412) 7049 632.9 5.2e-180 NP_002490 (OMIM: 601907) neogenin isoform 1 precur (1461) 6810 612.0 1.1e-173 NP_001166095 (OMIM: 601907) neogenin isoform 3 pre (1450) 6799 611.0 2e-173 XP_016877720 (OMIM: 601907) PREDICTED: neogenin is (1434) 6714 603.6 3.5e-171 XP_016877726 (OMIM: 601907) PREDICTED: neogenin is (1394) 6677 600.4 3.2e-170 XP_016877722 (OMIM: 601907) PREDICTED: neogenin is (1417) 5637 509.4 7.9e-143 XP_011519931 (OMIM: 601907) PREDICTED: neogenin is (1470) 5623 508.2 1.9e-142 XP_011519935 (OMIM: 601907) PREDICTED: neogenin is (1428) 5618 507.7 2.5e-142 XP_005254465 (OMIM: 601907) PREDICTED: neogenin is (1481) 5618 507.8 2.6e-142 XP_011519930 (OMIM: 601907) PREDICTED: neogenin is (1481) 5618 507.8 2.6e-142 XP_016877725 (OMIM: 601907) PREDICTED: neogenin is (1397) 5400 488.7 1.4e-136 NP_001166094 (OMIM: 601907) neogenin isoform 2 pre (1408) 5393 488.1 2.1e-136 XP_016877727 (OMIM: 601907) PREDICTED: neogenin is (1381) 5286 478.7 1.4e-133 XP_016881058 (OMIM: 114500,120470,133239,157600) P (1427) 2917 271.5 3.3e-71 NP_005206 (OMIM: 114500,120470,133239,157600) netr (1447) 2603 244.0 6.2e-63 XP_016881057 (OMIM: 114500,120470,133239,157600) P (1445) 2600 243.8 7.4e-63 XP_011524145 (OMIM: 114500,120470,133239,157600) P (1443) 2497 234.8 3.8e-60 XP_016881059 (OMIM: 114500,120470,133239,157600) P (1102) 1641 159.8 1.1e-37 XP_011524146 (OMIM: 114500,120470,133239,157600) P (1102) 1641 159.8 1.1e-37 XP_016862494 (OMIM: 602431,610878) PREDICTED: roun (1396) 798 86.1 2e-15 XP_016862493 (OMIM: 602431,610878) PREDICTED: roun (1398) 798 86.1 2e-15 XP_016862486 (OMIM: 602431,610878) PREDICTED: roun (1438) 798 86.2 2.1e-15 XP_016862485 (OMIM: 602431,610878) PREDICTED: roun (1440) 798 86.2 2.1e-15 XP_016862481 (OMIM: 602431,610878) PREDICTED: roun (1489) 798 86.2 2.1e-15 XP_016862479 (OMIM: 602431,610878) PREDICTED: roun (1531) 798 86.2 2.2e-15 XP_016862491 (OMIM: 602431,610878) PREDICTED: roun (1402) 788 85.3 3.7e-15 XP_016862490 (OMIM: 602431,610878) PREDICTED: roun (1403) 788 85.3 3.7e-15 XP_011532287 (OMIM: 602431,610878) PREDICTED: roun (1405) 788 85.3 3.7e-15 XP_016862484 (OMIM: 602431,610878) PREDICTED: roun (1442) 788 85.3 3.8e-15 XP_016862483 (OMIM: 602431,610878) PREDICTED: roun (1445) 788 85.3 3.8e-15 XP_011532286 (OMIM: 602431,610878) PREDICTED: roun (1447) 788 85.3 3.8e-15 XP_016862480 (OMIM: 602431,610878) PREDICTED: roun (1496) 788 85.3 3.9e-15 XP_016862477 (OMIM: 602431,610878) PREDICTED: roun (1536) 788 85.3 4e-15 XP_011532285 (OMIM: 602431,610878) PREDICTED: roun (1538) 788 85.3 4e-15 XP_016862476 (OMIM: 602431,610878) PREDICTED: roun (1554) 788 85.3 4e-15 XP_011532284 (OMIM: 602431,610878) PREDICTED: roun (1557) 788 85.3 4e-15 XP_011532283 (OMIM: 602431,610878) PREDICTED: roun (1597) 788 85.3 4.1e-15 XP_016862495 (OMIM: 602431,610878) PREDICTED: roun (1379) 781 84.7 5.6e-15 NP_001276968 (OMIM: 602431,610878) roundabout homo (1382) 781 84.7 5.6e-15 XP_016862471 (OMIM: 602430) PREDICTED: roundabout (1626) 783 84.9 5.6e-15 XP_016862488 (OMIM: 602431,610878) PREDICTED: roun (1422) 781 84.7 5.7e-15 XP_016862487 (OMIM: 602431,610878) PREDICTED: roun (1424) 781 84.7 5.7e-15 NP_001276969 (OMIM: 602431,610878) roundabout homo (1443) 781 84.7 5.8e-15 XP_016862475 (OMIM: 602431,610878) PREDICTED: roun (1576) 781 84.7 6.2e-15 NP_598334 (OMIM: 602430) roundabout homolog 1 isof (1606) 780 84.6 6.7e-15 XP_011532280 (OMIM: 602430) PREDICTED: roundabout (1645) 780 84.6 6.8e-15 >>XP_016877721 (OMIM: 601907) PREDICTED: neogenin isofor (1454 aa) initn: 9689 init1: 9689 opt: 9689 Z-score: 4600.5 bits: 863.8 E(85289): 0 Smith-Waterman score: 9689; 100.0% identity (100.0% similar) in 1454 aa overlap (1-1454:1-1454) 10 20 30 40 50 60 pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE1 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE1 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE1 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE1 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMS 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE1 GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNG 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE1 SHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSN 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE1 IHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHS 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE1 SSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDP 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE1 EGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQ 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE1 QALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAH 1390 1400 1410 1420 1430 1440 1450 pF1KE1 LEGLMKDLNAITTA :::::::::::::: XP_016 LEGLMKDLNAITTA 1450 >>XP_016877724 (OMIM: 601907) PREDICTED: neogenin isofor (1401 aa) initn: 8596 init1: 8247 opt: 8261 Z-score: 3925.6 bits: 738.9 E(85289): 6.4e-212 Smith-Waterman score: 9191; 96.3% identity (96.4% similar) in 1454 aa overlap (1-1454:1-1401) 10 20 30 40 50 60 pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE1 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE1 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE1 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE1 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMS 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE1 GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNG 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE1 SHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSN 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE1 IHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHS :::::::::::::::::::::::::::::::::::::::: XP_016 IHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQ-------------------- 1210 1220 1230 1240 1270 1280 1290 1300 1310 1320 pF1KE1 SSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDP .:::::::::::::::::::::::::: XP_016 ---------------------------------QSVRNTPSTDTMPASSSQTCCTDHQDP 1250 1260 1330 1340 1350 1360 1370 1380 pF1KE1 EGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQ 1270 1280 1290 1300 1310 1320 1390 1400 1410 1420 1430 1440 pF1KE1 QALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAH 1330 1340 1350 1360 1370 1380 1450 pF1KE1 LEGLMKDLNAITTA :::::::::::::: XP_016 LEGLMKDLNAITTA 1390 1400 >>XP_011519934 (OMIM: 601907) PREDICTED: neogenin isofor (1447 aa) initn: 8137 init1: 5611 opt: 8119 Z-score: 3858.3 bits: 726.5 E(85289): 3.6e-208 Smith-Waterman score: 9431; 97.3% identity (97.3% similar) in 1470 aa overlap (1-1454:1-1447) 10 20 30 40 50 60 pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP 790 800 810 820 830 840 850 860 870 880 pF1KE1 LYESAVTRPHT----------------VPDPTPMMPPVGVQASILSHDTIRITWADNSLP ::::::::::: ::::::::::::::::::::::::::::::::: XP_011 LYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLP 850 860 870 880 890 900 890 900 910 920 930 940 pF1KE1 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KE1 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KE1 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGK ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK------- 1030 1040 1050 1060 1070 1070 1080 1090 1100 1110 1120 pF1KE1 GSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT :::::::::::::::::::::::::::::::::::::::::::: XP_011 ----------------GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT 1080 1090 1100 1110 1130 1140 1150 1160 1170 1180 pF1KE1 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP 1120 1130 1140 1150 1160 1170 1190 1200 1210 1220 1230 1240 pF1KE1 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVIS 1180 1190 1200 1210 1220 1230 1250 1260 1270 1280 1290 1300 pF1KE1 AHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDT 1240 1250 1260 1270 1280 1290 1310 1320 1330 1340 1350 1360 pF1KE1 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG 1300 1310 1320 1330 1340 1350 1370 1380 1390 1400 1410 1420 pF1KE1 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED 1360 1370 1380 1390 1400 1410 1430 1440 1450 pF1KE1 SESSYEPDELTKEMAHLEGLMKDLNAITTA :::::::::::::::::::::::::::::: XP_011 SESSYEPDELTKEMAHLEGLMKDLNAITTA 1420 1430 1440 >>XP_011519932 (OMIM: 601907) PREDICTED: neogenin isofor (1465 aa) initn: 6999 init1: 6999 opt: 7064 Z-score: 3359.5 bits: 634.2 E(85289): 2.2e-180 Smith-Waterman score: 9657; 99.2% identity (99.2% similar) in 1465 aa overlap (1-1454:1-1465) 10 20 30 40 50 60 pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE1 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE1 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE1 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT 970 980 990 1000 1010 1020 1030 1040 1050 1060 pF1KE1 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKA-----------SGSGGKGSRLP :::::::::::::::::::::::::::::::::::::: ::::::::::: XP_011 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLP 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KE1 DLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQK 1090 1100 1110 1120 1130 1140 1130 1140 1150 1160 1170 1180 pF1KE1 KKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQD 1150 1160 1170 1180 1190 1200 1190 1200 1210 1220 1230 1240 pF1KE1 ITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIH 1210 1220 1230 1240 1250 1260 1250 1260 1270 1280 1290 1300 pF1KE1 SLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASS 1270 1280 1290 1300 1310 1320 1310 1320 1330 1340 1350 1360 pF1KE1 SQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYD 1330 1340 1350 1360 1370 1380 1370 1380 1390 1400 1410 1420 pF1KE1 PALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSY 1390 1400 1410 1420 1430 1440 1430 1440 1450 pF1KE1 EPDELTKEMAHLEGLMKDLNAITTA ::::::::::::::::::::::::: XP_011 EPDELTKEMAHLEGLMKDLNAITTA 1450 1460 >>XP_016877723 (OMIM: 601907) PREDICTED: neogenin isofor (1412 aa) initn: 8243 init1: 6999 opt: 7049 Z-score: 3352.7 bits: 632.9 E(85289): 5.2e-180 Smith-Waterman score: 9159; 95.6% identity (95.6% similar) in 1465 aa overlap (1-1454:1-1412) 10 20 30 40 50 60 pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE1 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE1 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE1 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT 970 980 990 1000 1010 1020 1030 1040 1050 1060 pF1KE1 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKA-----------SGSGGKGSRLP :::::::::::::::::::::::::::::::::::::: ::::::::::: XP_016 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLP 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KE1 DLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQK 1090 1100 1110 1120 1130 1140 1130 1140 1150 1160 1170 1180 pF1KE1 KKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQD 1150 1160 1170 1180 1190 1200 1190 1200 1210 1220 1230 1240 pF1KE1 ITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIH ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQ--------- 1210 1220 1230 1240 1250 1250 1260 1270 1280 1290 1300 pF1KE1 SLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASS .::::::::::::::: XP_016 --------------------------------------------QSVRNTPSTDTMPASS 1260 1310 1320 1330 1340 1350 1360 pF1KE1 SQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYD 1270 1280 1290 1300 1310 1320 1370 1380 1390 1400 1410 1420 pF1KE1 PALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSY 1330 1340 1350 1360 1370 1380 1430 1440 1450 pF1KE1 EPDELTKEMAHLEGLMKDLNAITTA ::::::::::::::::::::::::: XP_016 EPDELTKEMAHLEGLMKDLNAITTA 1390 1400 1410 >>NP_002490 (OMIM: 601907) neogenin isoform 1 precursor (1461 aa) initn: 5728 init1: 2852 opt: 6810 Z-score: 3239.5 bits: 612.0 E(85289): 1.1e-173 Smith-Waterman score: 9439; 96.8% identity (96.8% similar) in 1481 aa overlap (1-1454:1-1461) 10 20 30 40 50 60 pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR :::::::::: :::::::::::::::::::::::::::::: NP_002 AGAQLIILEH--------------------APATTGPLPSAPRDVVASLVSTRFIKLTWR 430 440 450 460 490 500 510 520 530 540 pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG 530 540 550 560 570 580 610 620 630 640 650 660 pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD 650 660 670 680 690 700 730 740 750 760 770 780 pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP 710 720 730 740 750 760 790 800 810 820 830 840 pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP 770 780 790 800 810 820 850 860 870 880 pF1KE1 LYESAVTRPHT----------------VPDPTPMMPPVGVQASILSHDTIRITWADNSLP ::::::::::: ::::::::::::::::::::::::::::::::: NP_002 LYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLP 830 840 850 860 870 880 890 900 910 920 930 940 pF1KE1 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST 890 900 910 920 930 940 950 960 970 980 990 1000 pF1KE1 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA 950 960 970 980 990 1000 1010 1020 1030 1040 1050 pF1KE1 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKA------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKM 1010 1020 1030 1040 1050 1060 1060 1070 1080 1090 1100 1110 pF1KE1 -----SGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVV ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVV 1070 1080 1090 1100 1110 1120 1120 1130 1140 1150 1160 1170 pF1KE1 VIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPD 1130 1140 1150 1160 1170 1180 1180 1190 1200 1210 1220 1230 pF1KE1 PNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMP 1190 1200 1210 1220 1230 1240 1240 1250 1260 1270 1280 1290 pF1KE1 FDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANST 1250 1260 1270 1280 1290 1300 1300 1310 1320 1330 1340 1350 pF1KE1 ESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLK 1310 1320 1330 1340 1350 1360 1360 1370 1380 1390 1400 1410 pF1KE1 SFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAP 1370 1380 1390 1400 1410 1420 1420 1430 1440 1450 pF1KE1 EVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA ::::::::::::::::::::::::::::::::::::::::: NP_002 EVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA 1430 1440 1450 1460 >>NP_001166095 (OMIM: 601907) neogenin isoform 3 precurs (1450 aa) initn: 6997 init1: 4078 opt: 6799 Z-score: 3234.3 bits: 611.0 E(85289): 2e-173 Smith-Waterman score: 9471; 97.6% identity (97.6% similar) in 1470 aa overlap (1-1454:1-1450) 10 20 30 40 50 60 pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR :::::::::: :::::::::::::::::::::::::::::: NP_001 AGAQLIILEH--------------------APATTGPLPSAPRDVVASLVSTRFIKLTWR 430 440 450 460 490 500 510 520 530 540 pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG 530 540 550 560 570 580 610 620 630 640 650 660 pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD 650 660 670 680 690 700 730 740 750 760 770 780 pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP 710 720 730 740 750 760 790 800 810 820 830 840 pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP 770 780 790 800 810 820 850 860 870 880 pF1KE1 LYESAVTRPHT----------------VPDPTPMMPPVGVQASILSHDTIRITWADNSLP ::::::::::: ::::::::::::::::::::::::::::::::: NP_001 LYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLP 830 840 850 860 870 880 890 900 910 920 930 940 pF1KE1 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST 890 900 910 920 930 940 950 960 970 980 990 1000 pF1KE1 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 pF1KE1 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGK 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 pF1KE1 GSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 pF1KE1 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP 1130 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KE1 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVIS 1190 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 pF1KE1 AHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDT 1250 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 pF1KE1 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG 1310 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 pF1KE1 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED 1370 1380 1390 1400 1410 1420 1430 1440 1450 pF1KE1 SESSYEPDELTKEMAHLEGLMKDLNAITTA :::::::::::::::::::::::::::::: NP_001 SESSYEPDELTKEMAHLEGLMKDLNAITTA 1430 1440 1450 >>XP_016877720 (OMIM: 601907) PREDICTED: neogenin isofor (1434 aa) initn: 6712 init1: 6712 opt: 6714 Z-score: 3194.2 bits: 603.6 E(85289): 3.5e-171 Smith-Waterman score: 9513; 98.6% identity (98.6% similar) in 1454 aa overlap (1-1454:1-1434) 10 20 30 40 50 60 pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR :::::::::: :::::::::::::::::::::::::::::: XP_016 AGAQLIILEH--------------------APATTGPLPSAPRDVVASLVSTRFIKLTWR 430 440 450 460 490 500 510 520 530 540 pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG 530 540 550 560 570 580 610 620 630 640 650 660 pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD 650 660 670 680 690 700 730 740 750 760 770 780 pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP 710 720 730 740 750 760 790 800 810 820 830 840 pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP 770 780 790 800 810 820 850 860 870 880 890 900 pF1KE1 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK 830 840 850 860 870 880 910 920 930 940 950 960 pF1KE1 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KE1 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 pF1KE1 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMS 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 pF1KE1 GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNG 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 pF1KE1 SHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSN 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 pF1KE1 IHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHS 1190 1200 1210 1220 1230 1240 1270 1280 1290 1300 1310 1320 pF1KE1 SSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDP 1250 1260 1270 1280 1290 1300 1330 1340 1350 1360 1370 1380 pF1KE1 EGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQ 1310 1320 1330 1340 1350 1360 1390 1400 1410 1420 1430 1440 pF1KE1 QALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAH 1370 1380 1390 1400 1410 1420 1450 pF1KE1 LEGLMKDLNAITTA :::::::::::::: XP_016 LEGLMKDLNAITTA 1430 >>XP_016877726 (OMIM: 601907) PREDICTED: neogenin isofor (1394 aa) initn: 8069 init1: 5611 opt: 6677 Z-score: 3176.9 bits: 600.4 E(85289): 3.2e-170 Smith-Waterman score: 8933; 93.7% identity (93.7% similar) in 1470 aa overlap (1-1454:1-1394) 10 20 30 40 50 60 pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP 790 800 810 820 830 840 850 860 870 880 pF1KE1 LYESAVTRPHT----------------VPDPTPMMPPVGVQASILSHDTIRITWADNSLP ::::::::::: ::::::::::::::::::::::::::::::::: XP_016 LYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLP 850 860 870 880 890 900 890 900 910 920 930 940 pF1KE1 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KE1 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KE1 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGK ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK------- 1030 1040 1050 1060 1070 1070 1080 1090 1100 1110 1120 pF1KE1 GSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT :::::::::::::::::::::::::::::::::::::::::::: XP_016 ----------------GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT 1080 1090 1100 1110 1130 1140 1150 1160 1170 1180 pF1KE1 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP 1120 1130 1140 1150 1160 1170 1190 1200 1210 1220 1230 1240 pF1KE1 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQ---- 1180 1190 1200 1210 1220 1230 1250 1260 1270 1280 1290 1300 pF1KE1 AHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDT .:::::::::: XP_016 -------------------------------------------------QSVRNTPSTDT 1240 1310 1320 1330 1340 1350 1360 pF1KE1 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG 1250 1260 1270 1280 1290 1300 1370 1380 1390 1400 1410 1420 pF1KE1 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED 1310 1320 1330 1340 1350 1360 1430 1440 1450 pF1KE1 SESSYEPDELTKEMAHLEGLMKDLNAITTA :::::::::::::::::::::::::::::: XP_016 SESSYEPDELTKEMAHLEGLMKDLNAITTA 1370 1380 1390 >>XP_016877722 (OMIM: 601907) PREDICTED: neogenin isofor (1417 aa) initn: 8233 init1: 5611 opt: 5637 Z-score: 2685.2 bits: 509.4 E(85289): 7.9e-143 Smith-Waterman score: 9149; 95.2% identity (95.3% similar) in 1470 aa overlap (1-1454:1-1417) 10 20 30 40 50 60 pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP 790 800 810 820 830 840 850 860 870 880 pF1KE1 LYESAVTRPHT----------------VPDPTPMMPPVGVQASILSHDTIRITWADNSLP ::::::::::: ::::::::::::::::::::::::::::::::: XP_016 LYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLP 850 860 870 880 890 900 890 900 910 920 930 940 pF1KE1 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KE1 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KE1 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGK 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KE1 GSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT 1090 1100 1110 1120 1130 1140 1130 1140 1150 1160 1170 1180 pF1KE1 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP 1150 1160 1170 1180 1190 1200 1190 1200 1210 1220 1230 1240 pF1KE1 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQ---- 1210 1220 1230 1240 1250 1250 1260 1270 1280 1290 1300 pF1KE1 AHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDT .:::::::::: XP_016 -------------------------------------------------QSVRNTPSTDT 1260 1310 1320 1330 1340 1350 1360 pF1KE1 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG 1270 1280 1290 1300 1310 1320 1370 1380 1390 1400 1410 1420 pF1KE1 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED 1330 1340 1350 1360 1370 1380 1430 1440 1450 pF1KE1 SESSYEPDELTKEMAHLEGLMKDLNAITTA :::::::::::::::::::::::::::::: XP_016 SESSYEPDELTKEMAHLEGLMKDLNAITTA 1390 1400 1410 1454 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 23:42:29 2016 done: Sun Nov 6 23:42:32 2016 Total Scan time: 19.480 Total Display time: 0.840 Function used was FASTA [36.3.4 Apr, 2011]