Result of FASTA (omim) for pF1KB6642
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6642, 443 aa
  1>>>pF1KB6642 443 - 443 aa - 443 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.0127+/-0.000362; mu= 7.2144+/- 0.023
 mean_var=230.6623+/-46.688, 0's: 0 Z-trim(122.0): 434  B-trim: 41 in 1/55
 Lambda= 0.084447
 statistics sampled from 39050 (39561) to 39050 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.464), width:  16
 Scan time:  8.970

The best scores are:                                      opt bits E(85289)
NP_058634 (OMIM: 604633,614437) EGF-containing fib ( 443) 3284 412.8 9.1e-115
NP_001034438 (OMIM: 126600,601548) EGF-containing  ( 493) 1551 201.7 3.6e-51
NP_001034437 (OMIM: 126600,601548) EGF-containing  ( 493) 1551 201.7 3.6e-51
NP_006320 (OMIM: 219100,604580,608895,614434) fibu ( 448) 1540 200.3 8.4e-51
XP_005267324 (OMIM: 219100,604580,608895,614434) P ( 465) 1540 200.3 8.6e-51
XP_016876418 (OMIM: 219100,604580,608895,614434) P ( 392) 1525 198.4 2.7e-50
XP_011534659 (OMIM: 219100,604580,608895,614434) P ( 464) 1347 176.8   1e-43
XP_011534658 (OMIM: 219100,604580,608895,614434) P ( 481) 1347 176.8 1.1e-43
XP_011534660 (OMIM: 219100,604580,608895,614434) P ( 408) 1332 174.9 3.4e-43
XP_016859075 (OMIM: 126600,601548) PREDICTED: EGF- ( 413) 1069 142.9 1.5e-33
XP_005264262 (OMIM: 126600,601548) PREDICTED: EGF- ( 543) 1069 143.0 1.8e-33
NP_001157738 (OMIM: 601216,602090,613097) latent-t (1139)  664 94.0 2.1e-18
NP_066548 (OMIM: 601216,602090,613097) latent-tran (1256)  664 94.1 2.3e-18
XP_011543335 (OMIM: 601216,602090,613097) PREDICTE (1265)  664 94.1 2.3e-18
NP_001123616 (OMIM: 601216,602090,613097) latent-t (1303)  664 94.1 2.3e-18
XP_011543334 (OMIM: 601216,602090,613097) PREDICTE (1312)  664 94.1 2.3e-18
XP_011525684 (OMIM: 604710,613177) PREDICTED: late (1554)  638 91.0 2.4e-17
XP_016857926 (OMIM: 603075,608548) PREDICTED: hemi (4976)  620 89.4 2.4e-16
NP_114141 (OMIM: 603075,608548) hemicentin-1 precu (5635)  620 89.4 2.6e-16
XP_016859599 (OMIM: 150390) PREDICTED: latent-tran (1639)  608 87.4 3.1e-16
XP_016859597 (OMIM: 150390) PREDICTED: latent-tran (1681)  608 87.4 3.1e-16
XP_011531158 (OMIM: 150390) PREDICTED: latent-tran (1682)  608 87.4 3.1e-16
XP_011508340 (OMIM: 603075,608548) PREDICTED: hemi (5518)  615 88.8 3.9e-16
XP_011525689 (OMIM: 604710,613177) PREDICTED: late (1421)  596 85.9 7.7e-16
XP_011525688 (OMIM: 604710,613177) PREDICTED: late (1436)  596 85.9 7.7e-16
XP_016882843 (OMIM: 604710,613177) PREDICTED: late (1438)  596 85.9 7.8e-16
XP_011525687 (OMIM: 604710,613177) PREDICTED: late (1478)  596 85.9 7.9e-16
XP_011525686 (OMIM: 604710,613177) PREDICTED: late (1480)  596 85.9 7.9e-16
XP_011525685 (OMIM: 604710,613177) PREDICTED: late (1522)  596 85.9 8.1e-16
XP_016882842 (OMIM: 604710,613177) PREDICTED: late (1549)  596 85.9 8.2e-16
NP_001036010 (OMIM: 604710,613177) latent-transfor (1557)  596 85.9 8.2e-16
NP_003564 (OMIM: 604710,613177) latent-transformin (1587)  596 85.9 8.3e-16
XP_016882841 (OMIM: 604710,613177) PREDICTED: late (1591)  596 85.9 8.3e-16
XP_011525682 (OMIM: 604710,613177) PREDICTED: late (1593)  596 85.9 8.3e-16
XP_011525683 (OMIM: 604710,613177) PREDICTED: late (1593)  596 85.9 8.3e-16
XP_011525681 (OMIM: 604710,613177) PREDICTED: late (1595)  596 85.9 8.3e-16
XP_011525680 (OMIM: 604710,613177) PREDICTED: late (1611)  596 85.9 8.4e-16
NP_001036009 (OMIM: 604710,613177) latent-transfor (1624)  596 85.9 8.4e-16
XP_011525679 (OMIM: 604710,613177) PREDICTED: late (1635)  596 85.9 8.5e-16
XP_011525678 (OMIM: 604710,613177) PREDICTED: late (1662)  596 85.9 8.6e-16
NP_000129 (OMIM: 102370,129600,134797,154700,18490 (2871)  594 85.9 1.5e-15
XP_016864717 (OMIM: 121050,612570,616118) PREDICTE (2861)  572 83.3 9.4e-15
XP_011539190 (OMIM: 604266) PREDICTED: multiple ep (1364)  566 82.2 9.4e-15
NP_001990 (OMIM: 121050,612570,616118) fibrillin-2 (2912)  572 83.3 9.5e-15
NP_001400 (OMIM: 604266) multiple epidermal growth (1541)  566 82.2   1e-14
XP_016856022 (OMIM: 604266) PREDICTED: multiple ep (1559)  566 82.2   1e-14
XP_011539188 (OMIM: 604266) PREDICTED: multiple ep (1560)  566 82.2   1e-14
XP_011539187 (OMIM: 604266) PREDICTED: multiple ep (1603)  566 82.3 1.1e-14
NP_006478 (OMIM: 135820,608180) fibulin-1 isoform  ( 566)  546 79.3 2.8e-14
NP_006476 (OMIM: 135820,608180) fibulin-1 isoform  ( 601)  546 79.4 2.9e-14


>>NP_058634 (OMIM: 604633,614437) EGF-containing fibulin  (443 aa)
 initn: 3284 init1: 3284 opt: 3284  Z-score: 2181.4  bits: 412.8 E(85289): 9.1e-115
Smith-Waterman score: 3284; 99.8% identity (100.0% similar) in 443 aa overlap (1-443:1-443)

               10        20        30        40        50        60
pF1KB6 MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 IPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 IPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 PGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 PGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 CSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTC
       ::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
NP_058 CSDIDECSYSSYLCQYRCINEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 VNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 VNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 FQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 FQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM
              370       380       390       400       410       420

              430       440   
pF1KB6 NSLMSYRASSVLRLTVFVGAYTF
       :::::::::::::::::::::::
NP_058 NSLMSYRASSVLRLTVFVGAYTF
              430       440   

>>NP_001034438 (OMIM: 126600,601548) EGF-containing fibu  (493 aa)
 initn: 1846 init1: 693 opt: 1551  Z-score: 1039.8  bits: 201.7 E(85289): 3.6e-51
Smith-Waterman score: 1774; 50.4% identity (70.8% similar) in 476 aa overlap (29-443:19-493)

               10        20        30        40        50        60
pF1KB6 MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLT
                                   :.::  .::.:::::::::  :.:.:..::  
NP_001           MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDI
                         10        20        30        40        50

               70        80        90                              
pF1KB6 IPEACKGEMKCINHYGGYLCLPRSAAVIND------------------------------
       .:.:::: :::.::::::::::..: .: .                              
NP_001 VPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATS
               60        70        80        90       100       110

                                      100             110       120
pF1KB6 --LHG----------EGPP------------PPVPPAQHP-NP-----CPPGYEPDDQDS
         : :           ::              :. : . : ::     :  ::: .... 
NP_001 GVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNV
              120       130       140       150       160       170

              130       140       150       160       170          
pF1KB6 CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYR-YCQHRCVN
       : :.:::. . :.:: .: : :: ::. : :: ::.: : .:::::::    ::..::::
NP_001 CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVN
              180       190       200       210       220       230

     180       190       200       210       220       230         
pF1KB6 LPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGF
        :::: ::: :::::. :: .:::.:::: .  : :.:.:  :.:.:.:.:::::  : .
NP_001 TPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRL
              240       250       260       270       280       290

     240       250       260       270       280       290         
pF1KB6 SCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQT
       .: :::::  :::::::.::::::.::: ::::::.. .: ::::.:::. ...: : . 
NP_001 NCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET-TNECREDEM
              300       310       320       330       340          

     300       310       320       330       340       350         
pF1KB6 CVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPAD
       : :.:::.::   : : .::: . ::::.::.:: .::: :.:::..::.: :.::::.:
NP_001 CWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSD
     350       360       370       380       390       400         

     360       370       380       390       400       410         
pF1KB6 VFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVT
       .::::::..: .. :.:.:..:: .:.::.:: . :::::::.. ..::::...::::.:
NP_001 IFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLT
     410       420       430       440       450       460         

     420       430       440   
pF1KB6 MNSLMSYRASSVLRLTVFVGAYTF
       ..:. ..:.:::::::..:: ..:
NP_001 VSSIGTFRTSSVLRLTIIVGPFSF
     470       480       490   

>>NP_001034437 (OMIM: 126600,601548) EGF-containing fibu  (493 aa)
 initn: 1846 init1: 693 opt: 1551  Z-score: 1039.8  bits: 201.7 E(85289): 3.6e-51
Smith-Waterman score: 1774; 50.4% identity (70.8% similar) in 476 aa overlap (29-443:19-493)

               10        20        30        40        50        60
pF1KB6 MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLT
                                   :.::  .::.:::::::::  :.:.:..::  
NP_001           MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDI
                         10        20        30        40        50

               70        80        90                              
pF1KB6 IPEACKGEMKCINHYGGYLCLPRSAAVIND------------------------------
       .:.:::: :::.::::::::::..: .: .                              
NP_001 VPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATS
               60        70        80        90       100       110

                                      100             110       120
pF1KB6 --LHG----------EGPP------------PPVPPAQHP-NP-----CPPGYEPDDQDS
         : :           ::              :. : . : ::     :  ::: .... 
NP_001 GVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNV
              120       130       140       150       160       170

              130       140       150       160       170          
pF1KB6 CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYR-YCQHRCVN
       : :.:::. . :.:: .: : :: ::. : :: ::.: : .:::::::    ::..::::
NP_001 CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVN
              180       190       200       210       220       230

     180       190       200       210       220       230         
pF1KB6 LPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGF
        :::: ::: :::::. :: .:::.:::: .  : :.:.:  :.:.:.:.:::::  : .
NP_001 TPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRL
              240       250       260       270       280       290

     240       250       260       270       280       290         
pF1KB6 SCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQT
       .: :::::  :::::::.::::::.::: ::::::.. .: ::::.:::. ...: : . 
NP_001 NCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET-TNECREDEM
              300       310       320       330       340          

     300       310       320       330       340       350         
pF1KB6 CVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPAD
       : :.:::.::   : : .::: . ::::.::.:: .::: :.:::..::.: :.::::.:
NP_001 CWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSD
     350       360       370       380       390       400         

     360       370       380       390       400       410         
pF1KB6 VFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVT
       .::::::..: .. :.:.:..:: .:.::.:: . :::::::.. ..::::...::::.:
NP_001 IFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLT
     410       420       430       440       450       460         

     420       430       440   
pF1KB6 MNSLMSYRASSVLRLTVFVGAYTF
       ..:. ..:.:::::::..:: ..:
NP_001 VSSIGTFRTSSVLRLTIIVGPFSF
     470       480       490   

>>NP_006320 (OMIM: 219100,604580,608895,614434) fibulin-  (448 aa)
 initn: 1703 init1: 791 opt: 1540  Z-score: 1033.0  bits: 200.3 E(85289): 8.4e-51
Smith-Waterman score: 1734; 50.1% identity (72.8% similar) in 453 aa overlap (8-443:1-448)

               10        20        30        40        50        60
pF1KB6 MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLT
              .::   . .. .: :   :: ...     ..::.:.. : .: .: :..:: :
NP_006        MPGIKRILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSGQCLDIDECRT
                      10        20             30        40        

               70        80        90               100            
pF1KB6 IPEACKGEMKCINHYGGYLCLPRSAAVINDLHGE-------GP-PPPVPPAQHPN-P---
       :::::.:.: :.:. :::::.::.  :    ...       :: :  .:: . :: :   
NP_006 IPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTIS
       50        60        70        80        90       100        

          110       120       130       140       150       160    
pF1KB6 ----CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVD
           :  ::. :....::::::::   :.: :.: : :  :.: :.: :::  .  .:.:
NP_006 RPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLD
      110       120       130       140       150       160        

          170       180       190       200       210       220    
pF1KB6 IDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTF
       :::::: :::. :.:.:::. : :.::: :. ..::: :::::    :: : : :.::.:
NP_006 IDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSF
      170       180       190       200       210       220        

          230       240       250       260       270        280   
pF1KB6 LCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLA-TRLCQD
       .:::  ::::..::  :::.::::.: .:::..:::.:: . : :: :: ::  .: :::
NP_006 ICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQD
      230       240       250       260       270       280        

           290       300       310       320       330       340   
pF1KB6 IDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSI
       :.:::   : :.  ::: :..::..:.:  :: :::...:.:::.::: :: ::.:: .:
NP_006 INECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTI
      290       300       310       320       330       340        

           350       360       370       380       390       400   
pF1KB6 VHRYMTITSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLAR
       ..: : ..: ::::::.::.:::. :::::  :::..::   .::.:: . .:: ::..:
NP_006 LYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTR
      350       360       370       380       390       400        

           410       420       430       440   
pF1KB6 PVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF
       :. ::::  :::::.:.:.....:.:::.:: ..:. : :
NP_006 PIKGPREIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF
      410       420       430       440        

>>XP_005267324 (OMIM: 219100,604580,608895,614434) PREDI  (465 aa)
 initn: 1703 init1: 791 opt: 1540  Z-score: 1032.8  bits: 200.3 E(85289): 8.6e-51
Smith-Waterman score: 1725; 50.2% identity (73.2% similar) in 448 aa overlap (13-443:23-465)

                         10        20        30        40        50
pF1KB6           MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQ
                             .. .. .: :   :: ...     ..::.:.. : .: 
XP_005 MFVWDSHRSFKPMRSGNCRQRYMILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSG
               10        20        30        40             50     

               60        70        80        90               100  
pF1KB6 HCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGE-------GP-PPPVPP
       .: :..:: ::::::.:.: :.:. :::::.::.  :    ...       :: :  .::
XP_005 QCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPP
          60        70        80        90       100       110     

                    110       120       130       140       150    
pF1KB6 AQHPN-P-------CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDG
        . :: :       :  ::. :....::::::::   :.: :.: : :  :.: :.: ::
XP_005 LSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDG
         120       130       140       150       160       170     

          160       170       180       190       200       210    
pF1KB6 YRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCE
       :  .  .:.::::::: :::. :.:.:::. : :.::: :. ..::: :::::    :: 
XP_005 YWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCV
         180       190       200       210       220       230     

          220       230       240       250       260       270    
pF1KB6 QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQ
       : : :.::.:.:::  ::::..::  :::.::::.: .:::..:::.:: . : :: :: 
XP_005 QTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYI
         240       250       260       270       280       290     

           280       290       300       310       320       330   
pF1KB6 LLA-TRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASN
       ::  .: ::::.:::   : :.  ::: :..::..:.:  :: :::...:.:::.::: :
XP_005 LLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAEN
         300       310       320       330       340       350     

           340       350       360       370       380       390   
pF1KB6 PLCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQIN
       : ::.:: .:..: : ..: ::::::.::.:::. :::::  :::..::   .::.:: .
XP_005 PGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTG
         360       370       380       390       400       410     

           400       410       420       430       440   
pF1KB6 NVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF
        .:: ::..::. ::::  :::::.:.:.....:.:::.:: ..:. : :
XP_005 PISATLVMTRPIKGPREIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF
         420       430       440       450       460     

>>XP_016876418 (OMIM: 219100,604580,608895,614434) PREDI  (392 aa)
 initn: 1485 init1: 791 opt: 1525  Z-score: 1023.8  bits: 198.4 E(85289): 2.7e-50
Smith-Waterman score: 1581; 52.3% identity (73.7% similar) in 392 aa overlap (69-443:1-392)

       40        50        60        70        80        90        
pF1KB6 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGE----
                                     : :.:. :::::.::.  :    ...    
XP_016                               MMCVNQNGGYLCIPRTNPVYRGPYSNPYST
                                             10        20        30

              100               110       120       130       140  
pF1KB6 ---GP-PPPVPPAQHPN-P-------CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHN
          :: :  .:: . :: :       :  ::. :....::::::::   :.: :.: : :
XP_016 PYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICIN
               40        50        60        70        80        90

            150       160       170       180       190       200  
pF1KB6 LPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCV
         :.: :.: :::  .  .:.::::::: :::. :.:.:::. : :.::: :. ..::: 
XP_016 TEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQ
              100       110       120       130       140       150

            210       220       230       240       250       260  
pF1KB6 DVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEP
       :::::    :: : : :.::.:.:::  ::::..::  :::.::::.: .:::..:::.:
XP_016 DVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQP
              160       170       180       190       200       210

            270        280       290       300       310       320 
pF1KB6 GRFSCHCPQGYQLLA-TRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQ
       : . : :: :: ::  .: ::::.:::   : :.  ::: :..::..:.:  :: :::..
XP_016 GTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLR
              220       230       240       250       260       270

             330       340       350       360       370       380 
pF1KB6 VSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNAFQIRAG
       .:.:::.::: :: ::.:: .:..: : ..: ::::::.::.:::. :::::  :::..:
XP_016 ISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSG
              280       290       300       310       320       330

             390       400       410       420       430       440 
pF1KB6 NSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAY
       :   .::.:: . .:: ::..::. ::::  :::::.:.:.....:.:::.:: ..:. :
XP_016 NEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVINFRGSSVIRLRIYVSQY
              340       350       360       370       380       390

         
pF1KB6 TF
        :
XP_016 PF
         

>>XP_011534659 (OMIM: 219100,604580,608895,614434) PREDI  (464 aa)
 initn: 1507 init1: 791 opt: 1347  Z-score: 905.8  bits: 176.8 E(85289): 1e-43
Smith-Waterman score: 1541; 49.4% identity (71.5% similar) in 407 aa overlap (8-397:1-402)

               10        20        30        40        50        60
pF1KB6 MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLT
              .::   . .. .: :   :: ...     ..::.:.. : .: .: :..:: :
XP_011        MPGIKRILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSGQCLDIDECRT
                      10        20             30        40        

               70        80        90               100            
pF1KB6 IPEACKGEMKCINHYGGYLCLPRSAAVINDLHGE-------GP-PPPVPPAQHPN-P---
       :::::.:.: :.:. :::::.::.  :    ...       :: :  .:: . :: :   
XP_011 IPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTIS
       50        60        70        80        90       100        

          110       120       130       140       150       160    
pF1KB6 ----CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVD
           :  ::. :....::::::::   :.: :.: : :  :.: :.: :::  .  .:.:
XP_011 RPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLD
      110       120       130       140       150       160        

          170       180       190       200       210       220    
pF1KB6 IDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTF
       :::::: :::. :.:.:::. : :.::: :. ..::: :::::    :: : : :.::.:
XP_011 IDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSF
      170       180       190       200       210       220        

          230       240       250       260       270        280   
pF1KB6 LCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLA-TRLCQD
       .:::  ::::..::  :::.::::.: .:::..:::.:: . : :: :: ::  .: :::
XP_011 ICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQD
      230       240       250       260       270       280        

           290       300       310       320       330       340   
pF1KB6 IDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSI
       :.:::   : :.  ::: :..::..:.:  :: :::...:.:::.::: :: ::.:: .:
XP_011 INECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTI
      290       300       310       320       330       340        

           350       360       370       380       390       400   
pF1KB6 VHRYMTITSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLAR
       ..: : ..: ::::::.::.:::. :::::  :::..::   .::.:.  ...:      
XP_011 LYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRRAFSTTAYEASSQ
      350       360       370       380       390       400        

           410       420       430       440                   
pF1KB6 PVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF                
                                                               
XP_011 ALSVEKQTGCGLCPGGTHTHLSGEGENNLANTTQSGDSQVKSRPMGCKRAPSVPPW
      410       420       430       440       450       460    

>>XP_011534658 (OMIM: 219100,604580,608895,614434) PREDI  (481 aa)
 initn: 1507 init1: 791 opt: 1347  Z-score: 905.6  bits: 176.8 E(85289): 1.1e-43
Smith-Waterman score: 1532; 49.5% identity (71.9% similar) in 402 aa overlap (13-397:23-419)

                         10        20        30        40        50
pF1KB6           MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQ
                             .. .. .: :   :: ...     ..::.:.. : .: 
XP_011 MFVWDSHRSFKPMRSGNCRQRYMILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSG
               10        20        30        40             50     

               60        70        80        90               100  
pF1KB6 HCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGE-------GP-PPPVPP
       .: :..:: ::::::.:.: :.:. :::::.::.  :    ...       :: :  .::
XP_011 QCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPP
          60        70        80        90       100       110     

                    110       120       130       140       150    
pF1KB6 AQHPN-P-------CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDG
        . :: :       :  ::. :....::::::::   :.: :.: : :  :.: :.: ::
XP_011 LSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDG
         120       130       140       150       160       170     

          160       170       180       190       200       210    
pF1KB6 YRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCE
       :  .  .:.::::::: :::. :.:.:::. : :.::: :. ..::: :::::    :: 
XP_011 YWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCV
         180       190       200       210       220       230     

          220       230       240       250       260       270    
pF1KB6 QRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQ
       : : :.::.:.:::  ::::..::  :::.::::.: .:::..:::.:: . : :: :: 
XP_011 QTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYI
         240       250       260       270       280       290     

           280       290       300       310       320       330   
pF1KB6 LLA-TRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASN
       ::  .: ::::.:::   : :.  ::: :..::..:.:  :: :::...:.:::.::: :
XP_011 LLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAEN
         300       310       320       330       340       350     

           340       350       360       370       380       390   
pF1KB6 PLCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQIN
       : ::.:: .:..: : ..: ::::::.::.:::. :::::  :::..::   .::.:.  
XP_011 PGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRRAF
         360       370       380       390       400       410     

           400       410       420       430       440             
pF1KB6 NVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF          
       ...:                                                        
XP_011 STTAYEASSQALSVEKQTGCGLCPGGTHTHLSGEGENNLANTTQSGDSQVKSRPMGCKRA
         420       430       440       450       460       470     

>>XP_011534660 (OMIM: 219100,604580,608895,614434) PREDI  (408 aa)
 initn: 1289 init1: 791 opt: 1332  Z-score: 896.6  bits: 174.9 E(85289): 3.4e-43
Smith-Waterman score: 1388; 51.7% identity (72.3% similar) in 346 aa overlap (69-397:1-346)

       40        50        60        70        80        90        
pF1KB6 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGE----
                                     : :.:. :::::.::.  :    ...    
XP_011                               MMCVNQNGGYLCIPRTNPVYRGPYSNPYST
                                             10        20        30

              100               110       120       130       140  
pF1KB6 ---GP-PPPVPPAQHPN-P-------CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHN
          :: :  .:: . :: :       :  ::. :....::::::::   :.: :.: : :
XP_011 PYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICIN
               40        50        60        70        80        90

            150       160       170       180       190       200  
pF1KB6 LPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCV
         :.: :.: :::  .  .:.::::::: :::. :.:.:::. : :.::: :. ..::: 
XP_011 TEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQ
              100       110       120       130       140       150

            210       220       230       240       250       260  
pF1KB6 DVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEP
       :::::    :: : : :.::.:.:::  ::::..::  :::.::::.: .:::..:::.:
XP_011 DVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQP
              160       170       180       190       200       210

            270        280       290       300       310       320 
pF1KB6 GRFSCHCPQGYQLLA-TRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQ
       : . : :: :: ::  .: ::::.:::   : :.  ::: :..::..:.:  :: :::..
XP_011 GTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLR
              220       230       240       250       260       270

             330       340       350       360       370       380 
pF1KB6 VSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNAFQIRAG
       .:.:::.::: :: ::.:: .:..: : ..: ::::::.::.:::. :::::  :::..:
XP_011 ISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSG
              280       290       300       310       320       330

             390       400       410       420       430       440 
pF1KB6 NSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAY
       :   .::.:.  ...:                                            
XP_011 NEGREFYMRRAFSTTAYEASSQALSVEKQTGCGLCPGGTHTHLSGEGENNLANTTQSGDS
              340       350       360       370       380       390

>>XP_016859075 (OMIM: 126600,601548) PREDICTED: EGF-cont  (413 aa)
 initn: 1570 init1: 602 opt: 1069  Z-score: 723.3  bits: 142.9 E(85289): 1.5e-33
Smith-Waterman score: 1376; 45.9% identity (68.8% similar) in 442 aa overlap (13-443:1-413)

               10        20          30        40        50        
pF1KB6 MLPCASCLPGSLLLWALLLLLLGSA--SPQDSEEPDSYTECTDGYEWDPDSQHCRDVNEC
                   .: ::.: .:  :  . ::.::  .::.:::::::::  :.:.:..::
XP_016             MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDEC
                           10        20        30        40        

       60        70        80        90       100       110        
pF1KB6 LTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQ
         .:.:::: :::.::::::::::..: .:  ...: :   . ::.  .    :      
XP_016 DIVPDACKGGMKCVNHYGGYLCLPKTAQII--VNNEQPQQETQPAEGTSGATTGV-----
       50        60        70          80        90       100      

      120       130       140       150       160       170        
pF1KB6 DSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCV
            :   ..:            :::.   .   .    :::   ..  :  .  .:  
XP_016 -----VAASSMATSGV--------LPGGGFVASAAAV--AGPE---MQTGRNNFVIRRNP
                  110               120            130       140   

      180             190       200       210          220         
pF1KB6 NLPG------SFRCQCEPGFQLGPNNRSCVDVNECDMGAP-C--EQRCFNSYGTFLCRCH
         :       : : ::  :.. . .:  : :..::  :.  :  .: :.:  :.: :.: 
XP_016 ADPQRIPSNPSHRIQCAAGYEQSEHN-VCQDIDECTAGTHNCRADQVCINLRGSFACQCP
           150       160        170       180       190       200  

     230       240       250       260       270       280         
pF1KB6 QGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECES
        ::.  . : .: :::::  :::::::.::::::.::: ::::::.. .: ::::.:::.
XP_016 PGYQ--KRGEQCVDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET
              210       220       230       240       250       260

     290       300       310       320       330       340         
pF1KB6 GAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMT
        ...: : . : :.:::.::   : : .::: . ::::.::.:: .::: :.:::..::.
XP_016 -TNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMS
               270       280       290       300       310         

     350       360       370       380       390       400         
pF1KB6 ITSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPR
       : :.::::.:.::::::..: .. :.:.:..:: .:.::.:: . :::::::.. ..:::
XP_016 IRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPR
     320       330       340       350       360       370         

     410       420       430       440   
pF1KB6 EYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF
       :...::::.:..:. ..:.:::::::..:: ..:
XP_016 EHIVDLEMLTVSSIGTFRTSSVLRLTIIVGPFSF
     380       390       400       410   




443 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 11:39:09 2016 done: Sat Nov  5 11:39:10 2016
 Total Scan time:  8.970 Total Display time:  0.060

Function used was FASTA [36.3.4 Apr, 2011]
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