Result of FASTA (omim) for pF1KE0116
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0116, 390 aa
  1>>>pF1KE0116 390 - 390 aa - 390 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 10.6580+/-0.000524; mu= -7.8907+/- 0.032
 mean_var=387.9551+/-77.402, 0's: 0 Z-trim(117.1): 66  B-trim: 0 in 0/56
 Lambda= 0.065115
 statistics sampled from 28808 (28864) to 28808 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.688), E-opt: 0.2 (0.338), width:  16
 Scan time:  9.400

The best scores are:                                      opt bits E(85289)
NP_064512 (OMIM: 600087) tuftelin isoform 1 [Homo  ( 390) 2501 249.3 1.1e-65
XP_016857712 (OMIM: 600087) PREDICTED: tuftelin is ( 371) 2353 235.4 1.7e-61
NP_001288246 (OMIM: 600087) tuftelin isoform 3 [Ho ( 409) 2353 235.4 1.8e-61
XP_016857713 (OMIM: 600087) PREDICTED: tuftelin is ( 346) 2198 220.8 3.9e-57
NP_001119809 (OMIM: 600087) tuftelin isoform 2 [Ho ( 365) 2198 220.8   4e-57
XP_011508263 (OMIM: 600087) PREDICTED: tuftelin is ( 331) 1991 201.3 2.7e-51
NP_001018110 (OMIM: 614071) myocardial zonula adhe ( 466)  375 49.7 1.7e-05


>>NP_064512 (OMIM: 600087) tuftelin isoform 1 [Homo sapi  (390 aa)
 initn: 2501 init1: 2501 opt: 2501  Z-score: 1299.9  bits: 249.3 E(85289): 1.1e-65
Smith-Waterman score: 2501; 100.0% identity (100.0% similar) in 390 aa overlap (1-390:1-390)

               10        20        30        40        50        60
pF1KE0 MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
              310       320       330       340       350       360

              370       380       390
pF1KE0 ARAKTENPGSIRISKPPSPKPMPVIRVVET
       ::::::::::::::::::::::::::::::
NP_064 ARAKTENPGSIRISKPPSPKPMPVIRVVET
              370       380       390

>>XP_016857712 (OMIM: 600087) PREDICTED: tuftelin isofor  (371 aa)
 initn: 2353 init1: 2353 opt: 2353  Z-score: 1225.1  bits: 235.4 E(85289): 1.7e-61
Smith-Waterman score: 2353; 100.0% identity (100.0% similar) in 370 aa overlap (21-390:2-371)

               10        20        30        40        50        60
pF1KE0 MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAG
                           ::::::::::::::::::::::::::::::::::::::::
XP_016                    MGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAG
                                  10        20        30        40 

               70        80        90       100       110       120
pF1KE0 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
              50        60        70        80        90       100 

              130       140       150       160       170       180
pF1KE0 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
             110       120       130       140       150       160 

              190       200       210       220       230       240
pF1KE0 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
             170       180       190       200       210       220 

              250       260       270       280       290       300
pF1KE0 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
             230       240       250       260       270       280 

              310       320       330       340       350       360
pF1KE0 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
             290       300       310       320       330       340 

              370       380       390
pF1KE0 ARAKTENPGSIRISKPPSPKPMPVIRVVET
       ::::::::::::::::::::::::::::::
XP_016 ARAKTENPGSIRISKPPSPKPMPVIRVVET
             350       360       370 

>>NP_001288246 (OMIM: 600087) tuftelin isoform 3 [Homo s  (409 aa)
 initn: 2353 init1: 2353 opt: 2353  Z-score: 1224.5  bits: 235.4 E(85289): 1.8e-61
Smith-Waterman score: 2353; 100.0% identity (100.0% similar) in 370 aa overlap (21-390:40-409)

                         10        20        30        40        50
pF1KE0           MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKT
                                     ::::::::::::::::::::::::::::::
NP_001 QLEKEECMQCVPCSPRTRVALLELYRAMCQGSVDILRLTLQGELTGDELEHIAQKAGRKT
      10        20        30        40        50        60         

               60        70        80        90       100       110
pF1KE0 YAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEAR
      70        80        90       100       110       120         

              120       130       140       150       160       170
pF1KE0 NCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVE
     130       140       150       160       170       180         

              180       190       200       210       220       230
pF1KE0 SLRKTVQDLLAKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLRKTVQDLLAKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVG
     190       200       210       220       230       240         

              240       250       260       270       280       290
pF1KE0 ELQRRLLGMETEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELQRRLLGMETEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHH
     250       260       270       280       290       300         

              300       310       320       330       340       350
pF1KE0 LDDMLKSQQRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDDMLKSQQRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEK
     310       320       330       340       350       360         

              360       370       380       390
pF1KE0 QISHGNFSTQARAKTENPGSIRISKPPSPKPMPVIRVVET
       ::::::::::::::::::::::::::::::::::::::::
NP_001 QISHGNFSTQARAKTENPGSIRISKPPSPKPMPVIRVVET
     370       380       390       400         

>>XP_016857713 (OMIM: 600087) PREDICTED: tuftelin isofor  (346 aa)
 initn: 2198 init1: 2198 opt: 2198  Z-score: 1146.7  bits: 220.8 E(85289): 3.9e-57
Smith-Waterman score: 2198; 100.0% identity (100.0% similar) in 345 aa overlap (46-390:2-346)

          20        30        40        50        60        70     
pF1KE0 EDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSLASELVESHDGHE
                                     ::::::::::::::::::::::::::::::
XP_016                              MAGRKTYAMVSSHSAGHSLASELVESHDGHE
                                            10        20        30 

          80        90       100       110       120       130     
pF1KE0 EIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQ
              40        50        60        70        80        90 

         140       150       160       170       180       190     
pF1KE0 EIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLLAKLQEAKRQHQSDCV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLLAKLQEAKRQHQSDCV
             100       110       120       130       140       150 

         200       210       220       230       240       250     
pF1KE0 AFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGMETEHQALLAKVREGEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGMETEHQALLAKVREGEV
             160       170       180       190       200       210 

         260       270       280       290       300       310     
pF1KE0 ALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQRKVRQMIEQLQNSKAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQRKVRQMIEQLQNSKAV
             220       230       240       250       260       270 

         320       330       340       350       360       370     
pF1KE0 IQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQARAKTENPGSIRISK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQARAKTENPGSIRISK
             280       290       300       310       320       330 

         380       390
pF1KE0 PPSPKPMPVIRVVET
       :::::::::::::::
XP_016 PPSPKPMPVIRVVET
             340      

>>NP_001119809 (OMIM: 600087) tuftelin isoform 2 [Homo s  (365 aa)
 initn: 2332 init1: 2198 opt: 2198  Z-score: 1146.5  bits: 220.8 E(85289): 4e-57
Smith-Waterman score: 2286; 93.6% identity (93.6% similar) in 390 aa overlap (1-390:1-365)

               10        20        30        40        50        60
pF1KE0 MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAG
       ::::::::::::::::::::                         :::::::::::::::
NP_001 MNGTRNWCTLVDVHPEDQAA-------------------------AGRKTYAMVSSHSAG
               10        20                                 30     

               70        80        90       100       110       120
pF1KE0 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
          40        50        60        70        80        90     

              130       140       150       160       170       180
pF1KE0 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
         100       110       120       130       140       150     

              190       200       210       220       230       240
pF1KE0 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
         160       170       180       190       200       210     

              250       260       270       280       290       300
pF1KE0 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
         220       230       240       250       260       270     

              310       320       330       340       350       360
pF1KE0 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
         280       290       300       310       320       330     

              370       380       390
pF1KE0 ARAKTENPGSIRISKPPSPKPMPVIRVVET
       ::::::::::::::::::::::::::::::
NP_001 ARAKTENPGSIRISKPPSPKPMPVIRVVET
         340       350       360     

>>XP_011508263 (OMIM: 600087) PREDICTED: tuftelin isofor  (331 aa)
 initn: 2117 init1: 1983 opt: 1991  Z-score: 1041.9  bits: 201.3 E(85289): 2.7e-51
Smith-Waterman score: 2003; 84.9% identity (84.9% similar) in 390 aa overlap (1-390:1-331)

               10        20        30        40        50        60
pF1KE0 MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAG
       ::::::::::::::::::::                                        
XP_011 MNGTRNWCTLVDVHPEDQAA----------------------------------------
               10        20                                        

               70        80        90       100       110       120
pF1KE0 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
                          :::::::::::::::::::::::::::::::::::::::::
XP_011 -------------------VYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
                                  30        40        50        60 

              130       140       150       160       170       180
pF1KE0 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
              70        80        90       100       110       120 

              190       200       210       220       230       240
pF1KE0 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
             130       140       150       160       170       180 

              250       260       270       280       290       300
pF1KE0 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
             190       200       210       220       230       240 

              310       320       330       340       350       360
pF1KE0 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
             250       260       270       280       290       300 

              370       380       390
pF1KE0 ARAKTENPGSIRISKPPSPKPMPVIRVVET
       ::::::::::::::::::::::::::::::
XP_011 ARAKTENPGSIRISKPPSPKPMPVIRVVET
             310       320       330 

>>NP_001018110 (OMIM: 614071) myocardial zonula adherens  (466 aa)
 initn: 450 init1: 240 opt: 375  Z-score: 219.6  bits: 49.7 E(85289): 1.7e-05
Smith-Waterman score: 383; 27.1% identity (58.0% similar) in 362 aa overlap (34-389:118-458)

            10        20        30        40        50        60   
pF1KE0 TRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSL
                                     . ::  ... ::  . :  .  ::.  . :
NP_001 VVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGD-YDEMRQKIRQLTQELSVSHAQQEYL
        90       100       110       120        130       140      

            70        80        90       100       110       120   
pF1KE0 ASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSK
        .. ......  . .... .. ..:..  .:.. ..  : . :..    ::.  :   .:
NP_001 ENH-IQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDK
         150       160       170       180       190       200     

           130       140       150       160         170       180 
pF1KE0 LDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDV--ESLRKTVQDLLA
       :          .: :  ::     .:  . : .   : .   : .:  :  .:  ..   
NP_001 L----------REKQRQLE----VAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEE
                   210           220       230       240       250 

             190       200       210       220       230       240 
pF1KE0 KLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGMET
       :::: .:.:...  :.    . . .  :..:  .:  :  .:.:. ..:::.: .  :: 
NP_001 KLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEK
             260       270       280       290       300       310 

             250       260       270       280       290       300 
pF1KE0 EHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQRK
       :.. :  .. : :.   :. .. .:  ...:.   ::.  :.:::.:.:::::.. ::.:
NP_001 ERHQLQLQLLEHET---EMSGELTD--SDKERYQQLEEASASLRERIRHLDDMVHCQQKK
             320          330         340       350       360      

             310       320       330       340       350       360 
pF1KE0 VRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQA
       :.::.:.... :  .:.:.  : .: :::..::.:: :...:...: : : .    . . 
NP_001 VKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREI
        370       380       390       400       410       420      

                 370       380       390       
pF1KE0 RAKTE----NPGSIRISKPPSPKPMPVIRVVET       
        .  .    . :  :    :: .  :  ::.:        
NP_001 GVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT
        430       440       450       460      




390 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 02:24:06 2016 done: Fri Nov  4 02:24:07 2016
 Total Scan time:  9.400 Total Display time:  0.030

Function used was FASTA [36.3.4 Apr, 2011]
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