Result of FASTA (omim) for pF1KB6862
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6862, 195 aa
  1>>>pF1KB6862 195 - 195 aa - 195 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.2953+/-0.000295; mu= 14.5113+/- 0.019
 mean_var=74.8026+/-15.374, 0's: 0 Z-trim(117.9): 66  B-trim: 111 in 1/54
 Lambda= 0.148291
 statistics sampled from 30268 (30354) to 30268 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.728), E-opt: 0.2 (0.356), width:  16
 Scan time:  5.550

The best scores are:                                      opt bits E(85289)
NP_037390 (OMIM: 606838) apoptosis-associated spec ( 195) 1264 278.9 3.6e-75
NP_660183 (OMIM: 606838) apoptosis-associated spec ( 176)  580 132.5 3.8e-31
NP_690865 (OMIM: 615700) pyrin domain-containing p (  89)  344 81.8 3.5e-16
NP_127500 (OMIM: 606579,606636,615225) NACHT, LRR  (1399)  332 80.1 1.8e-14
NP_055737 (OMIM: 606579,606636,615225) NACHT, LRR  (1429)  332 80.1 1.8e-14
NP_127499 (OMIM: 606579,606636,615225) NACHT, LRR  (1443)  332 80.1 1.8e-14
NP_127497 (OMIM: 606579,606636,615225) NACHT, LRR  (1473)  332 80.1 1.9e-14
NP_001185465 (OMIM: 134610,249100,608107) pyrin is ( 445)  182 47.7 3.3e-05
XP_011518233 (OMIM: 609650) PREDICTED: NACHT, LRR  ( 703)  165 44.2  0.0006
XP_016872741 (OMIM: 609650) PREDICTED: NACHT, LRR  ( 771)  165 44.2 0.00064
NP_001263629 (OMIM: 609650) NACHT, LRR and PYD dom ( 891)  165 44.2 0.00072
NP_612202 (OMIM: 609650) NACHT, LRR and PYD domain ( 892)  165 44.2 0.00072
XP_016878725 (OMIM: 134610,249100,608107) PREDICTE ( 780)  161 43.3  0.0012
NP_000234 (OMIM: 134610,249100,608107) pyrin isofo ( 781)  161 43.3  0.0012


>>NP_037390 (OMIM: 606838) apoptosis-associated speck-li  (195 aa)
 initn: 1264 init1: 1264 opt: 1264  Z-score: 1470.5  bits: 278.9 E(85289): 3.6e-75
Smith-Waterman score: 1264; 100.0% identity (100.0% similar) in 195 aa overlap (1-195:1-195)

               10        20        30        40        50        60
pF1KB6 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
              130       140       150       160       170       180

              190     
pF1KB6 LRESQSYLVEDLERS
       :::::::::::::::
NP_037 LRESQSYLVEDLERS
              190     

>>NP_660183 (OMIM: 606838) apoptosis-associated speck-li  (176 aa)
 initn: 579 init1: 579 opt: 580  Z-score: 680.2  bits: 132.5 E(85289): 3.8e-31
Smith-Waterman score: 1087; 90.3% identity (90.3% similar) in 195 aa overlap (1-195:1-176)

               10        20        30        40        50        60
pF1KB6 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA
       ::::::::::::::::::::::::::::::::                   :::::::::
NP_660 LETYGAELTANVLRDMGLQEMAGQLQAATHQG-------------------LHFIDQHRA
               70        80        90                          100 

              130       140       150       160       170       180
pF1KB6 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
             110       120       130       140       150       160 

              190     
pF1KB6 LRESQSYLVEDLERS
       :::::::::::::::
NP_660 LRESQSYLVEDLERS
             170      

>>NP_690865 (OMIM: 615700) pyrin domain-containing prote  (89 aa)
 initn: 344 init1: 344 opt: 344  Z-score: 411.5  bits: 81.8 E(85289): 3.5e-16
Smith-Waterman score: 344; 64.8% identity (81.8% similar) in 88 aa overlap (1-88:1-88)

               10        20        30        40        50        60
pF1KB6 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
       ::  :.::: .::::: :::::::.:: .::::::. ::::::: ..: .:::::::. :
NP_690 MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA
        : :.:::.. ::::: . : :..:: :                                
NP_690 YEDYAAELVVAVLRDMRMLEEAARLQRAA                               
               70        80                                        

>>NP_127500 (OMIM: 606579,606636,615225) NACHT, LRR and   (1399 aa)
 initn: 412 init1: 328 opt: 332  Z-score: 380.8  bits: 80.1 E(85289): 1.8e-14
Smith-Waterman score: 332; 44.5% identity (65.1% similar) in 146 aa overlap (54-192:1243-1385)

            30        40        50         60        70          80
pF1KB6 KLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVS-FYLETYGAELTANVL--RDMGLQE
                                     :.: : ::.   :. .  .:   .:  :  
NP_127 PEEVTFHLYLIPSDCSIRKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVW
           1220      1230      1240      1250      1260      1270  

                   90       100       110       120       130      
pF1KB6 MA----GQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDAL
        :    :.:. ::   .   :: : .:    :   :::.::.:  ::::::.:: .:: :
NP_127 EALVKPGDLMPAT---TLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKL
           1280         1290      1300      1310      1320         

        140       150       160       170       180       190      
pF1KB6 YGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS 
       .:.::..:::. : :: : ::.::::::.. .:.  ::: : :::.:.. .:. .:    
NP_127 HGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKG
    1330      1340      1350      1360      1370      1380         

NP_127 SKKGLLPLSS
    1390         

>>NP_055737 (OMIM: 606579,606636,615225) NACHT, LRR and   (1429 aa)
 initn: 412 init1: 328 opt: 332  Z-score: 380.7  bits: 80.1 E(85289): 1.8e-14
Smith-Waterman score: 332; 44.5% identity (65.1% similar) in 146 aa overlap (54-192:1273-1415)

            30        40        50         60        70          80
pF1KB6 KLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVS-FYLETYGAELTANVL--RDMGLQE
                                     :.: : ::.   :. .  .:   .:  :  
NP_055 PEEVTFHLYLIPSDCSIRKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVW
           1250      1260      1270      1280      1290      1300  

                   90       100       110       120       130      
pF1KB6 MA----GQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDAL
        :    :.:. ::   .   :: : .:    :   :::.::.:  ::::::.:: .:: :
NP_055 EALVKPGDLMPAT---TLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKL
           1310         1320      1330      1340      1350         

        140       150       160       170       180       190      
pF1KB6 YGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS 
       .:.::..:::. : :: : ::.::::::.. .:.  ::: : :::.:.. .:. .:    
NP_055 HGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKG
    1360      1370      1380      1390      1400      1410         

NP_055 SKKGLLPLSS
    1420         

>>NP_127499 (OMIM: 606579,606636,615225) NACHT, LRR and   (1443 aa)
 initn: 412 init1: 328 opt: 332  Z-score: 380.6  bits: 80.1 E(85289): 1.8e-14
Smith-Waterman score: 332; 44.5% identity (65.1% similar) in 146 aa overlap (54-192:1287-1429)

            30        40        50         60        70          80
pF1KB6 KLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVS-FYLETYGAELTANVL--RDMGLQE
                                     :.: : ::.   :. .  .:   .:  :  
NP_127 GCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVW
       1260      1270      1280      1290      1300      1310      

                   90       100       110       120       130      
pF1KB6 MA----GQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDAL
        :    :.:. ::   .   :: : .:    :   :::.::.:  ::::::.:: .:: :
NP_127 EALVKPGDLMPAT---TLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKL
       1320         1330      1340      1350      1360      1370   

        140       150       160       170       180       190      
pF1KB6 YGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS 
       .:.::..:::. : :: : ::.::::::.. .:.  ::: : :::.:.. .:. .:    
NP_127 HGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKG
          1380      1390      1400      1410      1420      1430   

NP_127 SKKGLLPLSS
          1440   

>>NP_127497 (OMIM: 606579,606636,615225) NACHT, LRR and   (1473 aa)
 initn: 412 init1: 328 opt: 332  Z-score: 380.5  bits: 80.1 E(85289): 1.9e-14
Smith-Waterman score: 332; 44.5% identity (65.1% similar) in 146 aa overlap (54-192:1317-1459)

            30        40        50         60        70          80
pF1KB6 KLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVS-FYLETYGAELTANVL--RDMGLQE
                                     :.: : ::.   :. .  .:   .:  :  
NP_127 GCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVW
       1290      1300      1310      1320      1330      1340      

                   90       100       110       120       130      
pF1KB6 MA----GQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDAL
        :    :.:. ::   .   :: : .:    :   :::.::.:  ::::::.:: .:: :
NP_127 EALVKPGDLMPAT---TLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKL
       1350         1360      1370      1380      1390      1400   

        140       150       160       170       180       190      
pF1KB6 YGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS 
       .:.::..:::. : :: : ::.::::::.. .:.  ::: : :::.:.. .:. .:    
NP_127 HGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKG
          1410      1420      1430      1440      1450      1460   

NP_127 SKKGLLPLSS
          1470   

>>NP_001185465 (OMIM: 134610,249100,608107) pyrin isofor  (445 aa)
 initn: 223 init1: 167 opt: 182  Z-score: 214.4  bits: 47.7 E(85289): 3.3e-05
Smith-Waterman score: 185; 32.4% identity (66.7% similar) in 108 aa overlap (6-113:7-105)

                10        20        30        40        50         
pF1KB6  MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSF
             : .:..::.:.  ...:::.:: .. ... ..::::. .     . ..  ::..
NP_001 MAKTPSDHLLSTLEELVPYDFEKFKFKLQNTSVQKEHSRIPRSQIQRARPVKMATLLVTY
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB6 YLETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHR
       : : :...:: .::: .. . .: .:. :. ::          ::..::.:  :      
NP_001 YGEEYAVQLTLQVLRAINQRLLAEELHRAAIQGR---------PPDTAASPRCHAQEGDP
               70        80        90                100       110 

     120       130       140       150       160       170         
pF1KB6 AALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQ
                                                                   
NP_001 VDGTCVRDSCSFPEAVSGHPQASGSRSPGCPRCQDSHERKSPGSLSPQPLPQCKRHLKQV
             120       130       140       150       160       170 

>>XP_011518233 (OMIM: 609650) PREDICTED: NACHT, LRR and   (703 aa)
 initn: 162 init1:  94 opt: 165  Z-score: 191.9  bits: 44.2 E(85289): 0.0006
Smith-Waterman score: 165; 32.8% identity (61.2% similar) in 116 aa overlap (4-118:18-130)

                             10        20        30         40     
pF1KB6               MGRARDAILDALENLTAEELKKFKLKLLSV-PLREGYGRIPRGALL
                        ::. .: :::.:. :.::.:. :: .: :  .: . :: : : 
XP_011 MDQPEAPCSSTGPRLAVARELLLAALEELSQEQLKRFRHKLRDVGP--DGRS-IPWGRLE
               10        20        30        40          50        

          50        60        70        80        90       100     
pF1KB6 SMDALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQ
         ::.::...:..::    . :.. ..:.    ...:.:::    :  : . . . .  .
XP_011 RADAVDLAEQLAQFYGPEPALEVARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSE
        60        70        80        90       100       110       

         110       120       130       140       150       160     
pF1KB6 SAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSF
          :   : .. :                                               
XP_011 YKKKYREHVLQLHARVKERNARSVKITKRFTKLLIAPESAAPEEAMGPAEEPEPGRARRS
       120       130       140       150       160       170       

>>XP_016872741 (OMIM: 609650) PREDICTED: NACHT, LRR and   (771 aa)
 initn: 162 init1:  94 opt: 165  Z-score: 191.4  bits: 44.2 E(85289): 0.00064
Smith-Waterman score: 165; 32.8% identity (61.2% similar) in 116 aa overlap (4-118:18-130)

                             10        20        30         40     
pF1KB6               MGRARDAILDALENLTAEELKKFKLKLLSV-PLREGYGRIPRGALL
                        ::. .: :::.:. :.::.:. :: .: :  .: . :: : : 
XP_016 MDQPEAPCSSTGPRLAVARELLLAALEELSQEQLKRFRHKLRDVGP--DGRS-IPWGRLE
               10        20        30        40          50        

          50        60        70        80        90       100     
pF1KB6 SMDALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQ
         ::.::...:..::    . :.. ..:.    ...:.:::    :  : . . . .  .
XP_016 RADAVDLAEQLAQFYGPEPALEVARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSE
        60        70        80        90       100       110       

         110       120       130       140       150       160     
pF1KB6 SAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSF
          :   : .. :                                               
XP_016 YKKKYREHVLQLHARVKERNARSVKITKRFTKLLIAPESAAPEEAMGPAEEPEPGRARRS
       120       130       140       150       160       170       




195 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 00:06:27 2016 done: Sat Nov  5 00:06:28 2016
 Total Scan time:  5.550 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
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