Result of FASTA (omim) for pF1KB8877
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8877, 168 aa
  1>>>pF1KB8877 168 - 168 aa - 168 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.3775+/-0.000517; mu= 5.8609+/- 0.031
 mean_var=170.3860+/-37.100, 0's: 0 Z-trim(113.0): 703  B-trim: 650 in 1/51
 Lambda= 0.098256
 statistics sampled from 21193 (22130) to 21193 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.651), E-opt: 0.2 (0.259), width:  16
 Scan time:  4.270

The best scores are:                                      opt bits E(85289)
NP_523240 (OMIM: 603369) cyclin-dependent kinase 4 ( 168) 1092 166.9 1.4e-41
NP_001253 (OMIM: 603369) cyclin-dependent kinase 4 ( 168) 1092 166.9 1.4e-41
NP_524145 (OMIM: 600927) cyclin-dependent kinase 4 ( 166)  437 74.0 1.2e-13
NP_001791 (OMIM: 600927) cyclin-dependent kinase 4 ( 166)  437 74.0 1.2e-13
NP_001182061 (OMIM: 155601,155755,600160,606719) c ( 167)  314 56.6 2.2e-08
NP_000068 (OMIM: 155601,155755,600160,606719) cycl ( 156)  311 56.1 2.8e-08
XP_011515978 (OMIM: 155601,155755,600160,606719) P ( 172)  311 56.2   3e-08
XP_011515977 (OMIM: 155601,155755,600160,606719) P ( 184)  311 56.2 3.1e-08
NP_004927 (OMIM: 600431) cyclin-dependent kinase 4 ( 138)  298 54.2 9.3e-08
NP_065082 (OMIM: 610734) ankyrin repeat domain-con ( 360)  257 48.9 9.5e-06
NP_001278147 (OMIM: 610734) ankyrin repeat domain- ( 446)  257 49.1 1.1e-05
NP_065815 (OMIM: 612184) caskin-1 [Homo sapiens]   (1431)  259 50.0 1.9e-05
NP_002805 (OMIM: 300880) 26S proteasome non-ATPase ( 226)  239 46.1 4.2e-05
NP_001123453 (OMIM: 610734) ankyrin repeat domain- ( 327)  240 46.5 4.8e-05
NP_001278148 (OMIM: 610734) ankyrin repeat domain- ( 413)  240 46.6 5.5e-05
XP_006719577 (OMIM: 607815) PREDICTED: ankyrin rep (1184)  245 47.9 6.5e-05
XP_016875147 (OMIM: 607815) PREDICTED: ankyrin rep (1188)  245 47.9 6.6e-05
XP_006719576 (OMIM: 607815) PREDICTED: ankyrin rep (1199)  245 47.9 6.6e-05
XP_006719575 (OMIM: 607815) PREDICTED: ankyrin rep (1200)  245 47.9 6.6e-05
XP_016875146 (OMIM: 607815) PREDICTED: ankyrin rep (1226)  245 47.9 6.7e-05
XP_006719573 (OMIM: 607815) PREDICTED: ankyrin rep (1235)  245 47.9 6.7e-05
NP_690001 (OMIM: 607815) ankyrin repeat and steril (1248)  245 47.9 6.8e-05
XP_016875145 (OMIM: 607815) PREDICTED: ankyrin rep (1250)  245 47.9 6.8e-05
XP_011536873 (OMIM: 607815) PREDICTED: ankyrin rep (1251)  245 47.9 6.8e-05
XP_005269086 (OMIM: 607815) PREDICTED: ankyrin rep (1256)  245 47.9 6.8e-05
XP_016875144 (OMIM: 607815) PREDICTED: ankyrin rep (1259)  245 47.9 6.8e-05
XP_006719572 (OMIM: 607815) PREDICTED: ankyrin rep (1259)  245 47.9 6.8e-05
XP_005269085 (OMIM: 607815) PREDICTED: ankyrin rep (1260)  245 47.9 6.8e-05
XP_006719571 (OMIM: 607815) PREDICTED: ankyrin rep (1260)  245 47.9 6.8e-05
XP_016875143 (OMIM: 607815) PREDICTED: ankyrin rep (1268)  245 47.9 6.8e-05
XP_016875142 (OMIM: 607815) PREDICTED: ankyrin rep (1272)  245 47.9 6.8e-05
XP_006719570 (OMIM: 607815) PREDICTED: ankyrin rep (1273)  245 47.9 6.8e-05
XP_016875141 (OMIM: 607815) PREDICTED: ankyrin rep (1281)  245 47.9 6.9e-05
XP_006719569 (OMIM: 607815) PREDICTED: ankyrin rep (1283)  245 47.9 6.9e-05
XP_006719567 (OMIM: 607815) PREDICTED: ankyrin rep (1284)  245 47.9 6.9e-05
XP_006719568 (OMIM: 607815) PREDICTED: ankyrin rep (1284)  245 47.9 6.9e-05
XP_016875140 (OMIM: 607815) PREDICTED: ankyrin rep (1285)  245 47.9 6.9e-05
NP_057062 (OMIM: 613932,616117) serine/threonine-p ( 835)  238 46.7  0.0001
XP_016871638 (OMIM: 600465,615493) PREDICTED: anky (1720)  242 47.7 0.00011
XP_016871637 (OMIM: 600465,615493) PREDICTED: anky (1725)  242 47.7 0.00011
XP_016871636 (OMIM: 600465,615493) PREDICTED: anky (1735)  242 47.7 0.00011
XP_016871635 (OMIM: 600465,615493) PREDICTED: anky (1737)  242 47.7 0.00011
XP_016871634 (OMIM: 600465,615493) PREDICTED: anky (1738)  242 47.7 0.00011
XP_016871633 (OMIM: 600465,615493) PREDICTED: anky (1741)  242 47.7 0.00011
XP_016871632 (OMIM: 600465,615493) PREDICTED: anky (1742)  242 47.7 0.00011
XP_016871631 (OMIM: 600465,615493) PREDICTED: anky (1747)  242 47.7 0.00011
XP_016871630 (OMIM: 600465,615493) PREDICTED: anky (1751)  242 47.7 0.00011
XP_016871629 (OMIM: 600465,615493) PREDICTED: anky (1763)  242 47.7 0.00011
XP_016871628 (OMIM: 600465,615493) PREDICTED: anky (1764)  242 47.7 0.00011
XP_016871627 (OMIM: 600465,615493) PREDICTED: anky (1785)  242 47.7 0.00011


>>NP_523240 (OMIM: 603369) cyclin-dependent kinase 4 inh  (168 aa)
 initn: 1092 init1: 1092 opt: 1092  Z-score: 867.6  bits: 166.9 E(85289): 1.4e-41
Smith-Waterman score: 1092; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:1-168)

               10        20        30        40        50        60
pF1KB8 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_523 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_523 ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE
               70        80        90       100       110       120

              130       140       150       160        
pF1KB8 FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::
NP_523 FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
              130       140       150       160        

>>NP_001253 (OMIM: 603369) cyclin-dependent kinase 4 inh  (168 aa)
 initn: 1092 init1: 1092 opt: 1092  Z-score: 867.6  bits: 166.9 E(85289): 1.4e-41
Smith-Waterman score: 1092; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:1-168)

               10        20        30        40        50        60
pF1KB8 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE
               70        80        90       100       110       120

              130       140       150       160        
pF1KB8 FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
              130       140       150       160        

>>NP_524145 (OMIM: 600927) cyclin-dependent kinase 4 inh  (166 aa)
 initn: 494 init1: 330 opt: 437  Z-score: 365.8  bits: 74.0 E(85289): 1.2e-13
Smith-Waterman score: 437; 45.8% identity (77.4% similar) in 155 aa overlap (6-159:9-161)

                  10        20         30        40        50      
pF1KB8    MAEPWGNELASAAARGDLEQLTSLLQNN-VNVNAQNGFGRTALQVMKLGNPEIARRL
               :..:..::::::....  ::. . :. .: : ::.:::::: .:.  :: .:
NP_524 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
               10        20        30        40        50        60

         60        70        80        90       100       110      
pF1KB8 LLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHL
       : .::.:...: .: . .:::::.::::::..:.:  ::::. :. : ::.:::..::: 
NP_524 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
               70        80        90       100       110       120

        120       130       140       150       160        
pF1KB8 RVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
        :: ::. .  :.. .:. .: :  .::   : ...:...:..         
NP_524 AVVSFLAAE--SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL    
                130       140       150       160          

>>NP_001791 (OMIM: 600927) cyclin-dependent kinase 4 inh  (166 aa)
 initn: 494 init1: 330 opt: 437  Z-score: 365.8  bits: 74.0 E(85289): 1.2e-13
Smith-Waterman score: 437; 45.8% identity (77.4% similar) in 155 aa overlap (6-159:9-161)

                  10        20         30        40        50      
pF1KB8    MAEPWGNELASAAARGDLEQLTSLLQNN-VNVNAQNGFGRTALQVMKLGNPEIARRL
               :..:..::::::....  ::. . :. .: : ::.:::::: .:.  :: .:
NP_001 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
               10        20        30        40        50        60

         60        70        80        90       100       110      
pF1KB8 LLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHL
       : .::.:...: .: . .:::::.::::::..:.:  ::::. :. : ::.:::..::: 
NP_001 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
               70        80        90       100       110       120

        120       130       140       150       160        
pF1KB8 RVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
        :: ::. .  :.. .:. .: :  .::   : ...:...:..         
NP_001 AVVSFLAAE--SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL    
                130       140       150       160          

>>NP_001182061 (OMIM: 155601,155755,600160,606719) cycli  (167 aa)
 initn: 312 init1: 181 opt: 314  Z-score: 271.6  bits: 56.6 E(85289): 2.2e-08
Smith-Waterman score: 314; 38.1% identity (69.4% similar) in 147 aa overlap (3-148:10-156)

                      10        20        30        40        50   
pF1KB8        MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIA
                :: .. ::.::::: .:.. .::. ..  :: :..::  .::: .:. ..:
NP_001 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVA
               10        20        30        40        50        60

            60        70         80        90       100       110  
pF1KB8 RRLLLRGANPDLKDRTGFAV-IHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAK
       . :::.::.:.  : . ..  .::::: :::::: .: .  : ....:  : ::. :: .
NP_001 ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE
               70        80        90       100       110       120

            120       130       140       150       160        
pF1KB8 EGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
        ::  :...:   .... :  . . :.:   ... :                    
NP_001 LGHRDVARYLRAAAGGTRGSNHARIDAAEGPSEMIGNHLWVCRSRHA         
              130       140       150       160                

>>NP_000068 (OMIM: 155601,155755,600160,606719) cyclin-d  (156 aa)
 initn: 312 init1: 181 opt: 311  Z-score: 269.6  bits: 56.1 E(85289): 2.8e-08
Smith-Waterman score: 311; 39.6% identity (70.5% similar) in 139 aa overlap (3-140:10-148)

                      10        20        30        40        50   
pF1KB8        MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIA
                :: .. ::.::::: .:.. .::. ..  :: :..::  .::: .:. ..:
NP_000 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVA
               10        20        30        40        50        60

            60        70         80        90       100       110  
pF1KB8 RRLLLRGANPDLKDRTGFAV-IHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAK
       . :::.::.:.  : . ..  .::::: :::::: .: .  : ....:  : ::. :: .
NP_000 ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE
               70        80        90       100       110       120

            120       130       140       150       160        
pF1KB8 EGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
        ::  :...:   .... :  . . :.:                            
NP_000 LGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD                    
              130       140       150                          

>>XP_011515978 (OMIM: 155601,155755,600160,606719) PREDI  (172 aa)
 initn: 312 init1: 181 opt: 311  Z-score: 269.1  bits: 56.2 E(85289): 3e-08
Smith-Waterman score: 311; 39.6% identity (70.5% similar) in 139 aa overlap (3-140:10-148)

                      10        20        30        40        50   
pF1KB8        MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIA
                :: .. ::.::::: .:.. .::. ..  :: :..::  .::: .:. ..:
XP_011 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVA
               10        20        30        40        50        60

            60        70         80        90       100       110  
pF1KB8 RRLLLRGANPDLKDRTGFAV-IHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAK
       . :::.::.:.  : . ..  .::::: :::::: .: .  : ....:  : ::. :: .
XP_011 ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE
               70        80        90       100       110       120

            120       130       140       150       160        
pF1KB8 EGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
        ::  :...:   .... :  . . :.:                            
XP_011 LGHRDVARYLRAAAGGTRGSNHARIDAAEGPSVTASIQVPGGEEGDFGSSYS    
              130       140       150       160       170      

>>XP_011515977 (OMIM: 155601,155755,600160,606719) PREDI  (184 aa)
 initn: 299 init1: 181 opt: 311  Z-score: 268.8  bits: 56.2 E(85289): 3.1e-08
Smith-Waterman score: 311; 39.6% identity (70.5% similar) in 139 aa overlap (3-140:10-148)

                      10        20        30        40        50   
pF1KB8        MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIA
                :: .. ::.::::: .:.. .::. ..  :: :..::  .::: .:. ..:
XP_011 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVA
               10        20        30        40        50        60

            60        70         80        90       100       110  
pF1KB8 RRLLLRGANPDLKDRTGFAV-IHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAK
       . :::.::.:.  : . ..  .::::: :::::: .: .  : ....:  : ::. :: .
XP_011 ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE
               70        80        90       100       110       120

            120       130       140       150       160            
pF1KB8 EGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ    
        ::  :...:   .... :  . . :.:                                
XP_011 LGHRDVARYLRAAAGGTRGSNHARIDAAEGPSAGWTNLRISKPNCAWHHLEISRSRLFCT
              130       140       150       160       170       180

>>NP_004927 (OMIM: 600431) cyclin-dependent kinase 4 inh  (138 aa)
 initn: 310 init1: 176 opt: 298  Z-score: 260.3  bits: 54.2 E(85289): 9.3e-08
Smith-Waterman score: 298; 45.2% identity (73.9% similar) in 115 aa overlap (9-122:18-132)

                        10        20        30        40        50 
pF1KB8          MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPE
                        :::::::: .:.. .::. ... :. : ::: :.::: .:. .
NP_004 MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSAR
               10        20        30        40        50        60

              60        70         80        90       100       110
pF1KB8 IARRLLLRGANPDLKDRTGFAV-IHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLA
       .:. :::.::.:.  : . ..  .::::: :::::: .: .  : ....:  : ::. ::
NP_004 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA
               70        80        90       100       110       120

              120       130       140       150       160        
pF1KB8 AKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
        ..::  :. .:                                              
NP_004 EERGHRDVAGYLRTATGD                                        
              130                                                

>>NP_065082 (OMIM: 610734) ankyrin repeat domain-contain  (360 aa)
 initn: 239 init1: 172 opt: 257  Z-score: 224.2  bits: 48.9 E(85289): 9.5e-06
Smith-Waterman score: 257; 32.2% identity (71.7% similar) in 152 aa overlap (12-161:155-304)

                                  10        20        30        40 
pF1KB8                    MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTA
                                     ::..: .. . ..: .. .... . : :::
NP_065 KKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTA
          130       140       150       160       170       180    

               50        60        70        80        90       100
pF1KB8 LQVMKL-GNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIED
       :.  .: :. :: ..::  ::. :..::   ...: : :.: :.... :    ::.:..:
NP_065 LHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRD
          190       200       210       220       230       240    

              110       120       130       140        150         
pF1KB8 NEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTAC-DLARLYGRNEVVSLMQAN
       .  . :::.:.. :....:: ...  . ... :...::::  : .:: .: ....:.  .
NP_065 KLLSTPLHVAVRTGQVEIVEHFLS-LGLEINARDREGDTALHDAVRL-NRYKIIKLLLLH
          250       260        270       280       290        300  

     160                                                         
pF1KB8 GAGGATNLQ                                                 
       ::                                                        
NP_065 GADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ
            310       320       330       340       350       360




168 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 19:57:21 2016 done: Sat Nov  5 19:57:21 2016
 Total Scan time:  4.270 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
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