FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6432, 344 aa 1>>>pF1KB6432 344 - 344 aa - 344 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0667+/-0.000342; mu= 13.2857+/- 0.021 mean_var=86.4471+/-17.068, 0's: 0 Z-trim(116.0): 25 B-trim: 26 in 1/52 Lambda= 0.137943 statistics sampled from 26898 (26922) to 26898 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.694), E-opt: 0.2 (0.316), width: 16 Scan time: 7.600 The best scores are: opt bits E(85289) NP_057670 (OMIM: 609431) MAP3K12-binding inhibitor ( 344) 2243 456.0 5.3e-128 NP_001138363 (OMIM: 609431) MAP3K12-binding inhibi ( 343) 2224 452.2 7.3e-127 XP_005267813 (OMIM: 609431) PREDICTED: MAP3K12-bin ( 281) 1718 351.5 1.3e-96 NP_001295039 (OMIM: 609431) MAP3K12-binding inhibi ( 282) 1718 351.5 1.3e-96 XP_016876856 (OMIM: 609431) PREDICTED: MAP3K12-bin ( 259) 1216 251.6 1.4e-66 XP_005267811 (OMIM: 609431) PREDICTED: MAP3K12-bin ( 322) 1216 251.6 1.7e-66 >>NP_057670 (OMIM: 609431) MAP3K12-binding inhibitory pr (344 aa) initn: 2243 init1: 2243 opt: 2243 Z-score: 2419.0 bits: 456.0 E(85289): 5.3e-128 Smith-Waterman score: 2243; 99.4% identity (99.4% similar) in 344 aa overlap (1-344:1-344) 10 20 30 40 50 60 pF1KB6 MAAATEHNRPSSGDRNLERRCSPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKL :::::: :::::::::::::: :::::::::::::::::::::::::::::::::::::: NP_057 MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 QSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 IGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 IGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 EFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSML 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 RDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSG 250 260 270 280 290 300 310 320 330 340 pF1KB6 KRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP :::::::::::::::::::::::::::::::::::::::::::: NP_057 KRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP 310 320 330 340 >>NP_001138363 (OMIM: 609431) MAP3K12-binding inhibitory (343 aa) initn: 2028 init1: 2028 opt: 2224 Z-score: 2398.6 bits: 452.2 E(85289): 7.3e-127 Smith-Waterman score: 2224; 99.1% identity (99.1% similar) in 344 aa overlap (1-344:1-343) 10 20 30 40 50 60 pF1KB6 MAAATEHNRPSSGDRNLERRCSPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKL :::::: :::::::::::::: :::::::::::::::::::::::::::::::::::::: NP_001 MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 IGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSML 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSG 250 260 270 280 290 300 310 320 330 340 pF1KB6 KRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP ::::::::: :::::::::::::::::::::::::::::::::: NP_001 KRRKVQPPQ-NYSLAELDEKISALKQALLRKSREAESMATHHLP 310 320 330 340 >>XP_005267813 (OMIM: 609431) PREDICTED: MAP3K12-binding (281 aa) initn: 1718 init1: 1718 opt: 1718 Z-score: 1855.7 bits: 351.5 E(85289): 1.3e-96 Smith-Waterman score: 1718; 99.2% identity (99.2% similar) in 263 aa overlap (1-263:1-263) 10 20 30 40 50 60 pF1KB6 MAAATEHNRPSSGDRNLERRCSPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKL :::::: :::::::::::::: :::::::::::::::::::::::::::::::::::::: XP_005 MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 IGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSML 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSG ::::::::::::::::::::::: XP_005 RDCGNQAVEERLQNIEAHLRLQTELFWKKKKSSTTSKLFTG 250 260 270 280 >>NP_001295039 (OMIM: 609431) MAP3K12-binding inhibitory (282 aa) initn: 1718 init1: 1718 opt: 1718 Z-score: 1855.7 bits: 351.5 E(85289): 1.3e-96 Smith-Waterman score: 1718; 99.2% identity (99.2% similar) in 263 aa overlap (1-263:1-263) 10 20 30 40 50 60 pF1KB6 MAAATEHNRPSSGDRNLERRCSPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKL :::::: :::::::::::::: :::::::::::::::::::::::::::::::::::::: NP_001 MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 IGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSML 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSG ::::::::::::::::::::::: NP_001 RDCGNQAVEERLQNIEAHLRLQTELFWKKKKSSTTSTELFTG 250 260 270 280 >>XP_016876856 (OMIM: 609431) PREDICTED: MAP3K12-binding (259 aa) initn: 1216 init1: 1216 opt: 1216 Z-score: 1316.3 bits: 251.6 E(85289): 1.4e-66 Smith-Waterman score: 1509; 90.9% identity (90.9% similar) in 263 aa overlap (1-263:1-241) 10 20 30 40 50 60 pF1KB6 MAAATEHNRPSSGDRNLERRCSPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKL :::::: :::::::::::::: :::::::::::::::::::::::::::::::::::::: XP_016 MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 IGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSML :::::::::: :::::::::::::::::::::::::::: XP_016 EFCNVIDCNQ----------------------VSRVVNTYGPQTRPEGIPGSGHKPNSML 190 200 210 250 260 270 280 290 300 pF1KB6 RDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSG ::::::::::::::::::::::: XP_016 RDCGNQAVEERLQNIEAHLRLQTELFWKKKKSSTTSKLFTG 220 230 240 250 >>XP_005267811 (OMIM: 609431) PREDICTED: MAP3K12-binding (322 aa) initn: 1216 init1: 1216 opt: 1216 Z-score: 1314.9 bits: 251.6 E(85289): 1.7e-66 Smith-Waterman score: 2034; 93.0% identity (93.0% similar) in 344 aa overlap (1-344:1-322) 10 20 30 40 50 60 pF1KB6 MAAATEHNRPSSGDRNLERRCSPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKL :::::: :::::::::::::: :::::::::::::::::::::::::::::::::::::: XP_005 MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 IGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSML :::::::::: :::::::::::::::::::::::::::: XP_005 EFCNVIDCNQ----------------------VSRVVNTYGPQTRPEGIPGSGHKPNSML 190 200 210 250 260 270 280 290 300 pF1KB6 RDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSG 220 230 240 250 260 270 310 320 330 340 pF1KB6 KRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP :::::::::::::::::::::::::::::::::::::::::::: XP_005 KRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP 280 290 300 310 320 344 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:57:47 2016 done: Fri Nov 4 22:57:48 2016 Total Scan time: 7.600 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]