Result of FASTA (omim) for pF1KE0230
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0230, 177 aa
  1>>>pF1KE0230 177 - 177 aa - 177 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.9949+/-0.000555; mu= 9.8427+/- 0.035
 mean_var=343.1269+/-67.134, 0's: 0 Z-trim(119.0): 164  B-trim: 133 in 1/49
 Lambda= 0.069238
 statistics sampled from 32462 (32634) to 32462 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.383), width:  16
 Scan time:  4.920

The best scores are:                                      opt bits E(85289)
NP_001005922 (OMIM: 148022) keratin-associated pro ( 278)  850 97.8 1.5e-20
NP_005544 (OMIM: 148021) keratin-associated protei ( 169)  724 84.8 7.4e-17
NP_114163 (OMIM: 608822) keratin-associated protei ( 174)  336 46.1 3.5e-05
NP_112228 (OMIM: 608820) keratin-associated protei ( 167)  303 42.8 0.00033
NP_112229 (OMIM: 608819) keratin-associated protei ( 177)  270 39.5  0.0034
NP_000418 (OMIM: 152445,604117) loricrin [Homo sap ( 312)  271 40.0  0.0041
XP_016878164 (OMIM: 612454) PREDICTED: multiple ep ( 854)  275 41.2  0.0051
XP_016878163 (OMIM: 612454) PREDICTED: multiple ep ( 854)  275 41.2  0.0051
XP_016878162 (OMIM: 612454) PREDICTED: multiple ep (1021)  275 41.3  0.0056
XP_016878161 (OMIM: 612454) PREDICTED: multiple ep (1044)  275 41.3  0.0056
NP_115821 (OMIM: 612454) multiple epidermal growth (1044)  275 41.3  0.0056
XP_016878160 (OMIM: 612454) PREDICTED: multiple ep (1092)  275 41.4  0.0058
XP_016878159 (OMIM: 612454) PREDICTED: multiple ep (1097)  275 41.4  0.0058


>>NP_001005922 (OMIM: 148022) keratin-associated protein  (278 aa)
 initn: 1474 init1: 457 opt: 850  Z-score: 489.8  bits: 97.8 E(85289): 1.5e-20
Smith-Waterman score: 902; 64.1% identity (72.8% similar) in 184 aa overlap (1-175:1-170)

               10        20        30        40        50        60
pF1KE0 MGCCGCSRGCGSGCGGCGSSCGGCGSGCGGCGSGRGGCGSGCGGCSSSCGGCGSRCYVPV
       :::::::       :::::::::::::::::::: ::::::::: .:::  :     :::
NP_001 MGCCGCS-------GGCGSSCGGCGSGCGGCGSGCGGCGSGCGGSGSSC--C-----VPV
                      10        20        30        40             

               70             80        90       100       110     
pF1KE0 CCCKPVCSWVPACSCTSCG-----SCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQ
       :::::::  ::.:::.:::     : :::::::::::: :::::::::::::::::: :.
NP_001 CCCKPVCCRVPTCSCSSCGKGGCGSSGGSKGGCGSCGGCKGGCGSCGGSKGGCGSCGGSK
         50        60        70        80        90       100      

         120       130         140         150       160       170 
pF1KE0 SSCCKPCCCSSGCGSSC--CQSSCCKP-CCCQS-SCCVPVCCQSSCCKPCCCQSNCCVPV
       ..: .    ..::::.:  : :::: : :::.   ::::.:  ::: :  : . .:   .
NP_001 GGCGSCGGSKGGCGSGCGGCGSSCCVPVCCCKPMCCCVPACSCSSCGKGGCGSCGCSKGA
        110       120       130       140       150       160      

                                                                   
pF1KE0 CCQCKI                                                      
       : .:                                                        
NP_001 CGSCGGSKGGCGSCGGCKGGCGSCGGSKGGCGSGCGGCGSGCGVPVCCCSCSSCGSCAGS
        170       180       190       200       210       220      

>--
 initn: 746 init1: 365 opt: 569  Z-score: 338.1  bits: 69.7 E(85289): 4.3e-12
Smith-Waterman score: 692; 61.1% identity (69.1% similar) in 149 aa overlap (11-159:171-277)

                                   10        20        30        40
pF1KE0                     MGCCGCSRGCGSGCGGCGSSCGGCGSGCGGCGSGRGGCGS
                                     :.. ::::: :::: .:::.::...:::::
NP_001 CCCVPACSCSSCGKGGCGSCGCSKGACGSCGGSKGGCGS-CGGCKGGCGSCGGSKGGCGS
              150       160       170        180       190         

               50        60        70        80        90       100
pF1KE0 GCGGCSSSCGGCGSRCYVPVCCCKPVCSWVPACSCTSCGSCGGSKGGCGSCGGSKGGCGS
       :::::.:.::       ::::::          ::.:::::.::::::::          
NP_001 GCGGCGSGCG-------VPVCCC----------SCSSCGSCAGSKGGCGS----------
     200              210                 220       230            

              110       120       130       140       150       160
pF1KE0 CGGSKGGCGSCGCSQSSCCKPCCCSSGCGSSCCQSSCCKPCCCQSSCCVPVCCQSSCCKP
                  .::: :::::::::::::::::::::::::: :::::::::::   :: 
NP_001 -----------SCSQCSCCKPCCCSSGCGSSCCQSSCCKPCCSQSSCCVPVCCQ---CKI
                       240       250       260       270           

              170       
pF1KE0 CCCQSNCCVPVCCQCKI

>>NP_005544 (OMIM: 148021) keratin-associated protein 5-  (169 aa)
 initn: 2062 init1: 475 opt: 724  Z-score: 423.7  bits: 84.8 E(85289): 7.4e-17
Smith-Waterman score: 899; 62.8% identity (68.6% similar) in 191 aa overlap (1-177:1-169)

               10        20        30        40        50        60
pF1KE0 MGCCGCSRGCGSGCGGCGSSCGGCGSGCGGCGSGRGGCGSGCGGCSSSCGGCGSRCYVPV
       ::::::: ::::.:::: ::::.::::: :::               ::      : .::
NP_005 MGCCGCSGGCGSSCGGCDSSCGSCGSGCRGCGP--------------SC------C-APV
               10        20        30                              

               70             80        90              100        
pF1KE0 CCCKPVCSWVPACSCTSCG-----SCGGSKGGCGSCGGSKGGC-------GSCGGSKGGC
        ::::::  ::::::.:::     ::::::::::::: :. .:       ..::.:   :
NP_005 YCCKPVCCCVPACSCSSCGKRGCGSCGGSKGGCGSCGCSQCSCCKPCCCSSGCGSSCCQC
      40        50        60        70        80        90         

      110         120       130       140       150       160      
pF1KE0 GSCG--CSQSSCCKPCCCSSGCGSSCCQSSCCKPCCCQSSCCVPVCCQSSCCKPCCCQSN
       . :   ::: ::::::: ::: :::::::::::::: .:: :   ::::::::::: :: 
NP_005 SCCKPYCSQCSCCKPCCSSSGRGSSCCQSSCCKPCC-SSSGCGSSCCQSSCCKPCCSQSR
     100       110       120       130        140       150        

        170       
pF1KE0 CCVPVCCQCKI
       :::::: ::::
NP_005 CCVPVCYQCKI
      160         

>>NP_114163 (OMIM: 608822) keratin-associated protein 1-  (174 aa)
 initn: 464 init1: 259 opt: 336  Z-score: 214.1  bits: 46.1 E(85289): 3.5e-05
Smith-Waterman score: 336; 45.6% identity (65.6% similar) in 90 aa overlap (91-172:9-95)

               70        80        90        100       110         
pF1KE0 CCCKPVCSWVPACSCTSCGSCGGSKGGCGSCG-GSKGGCGSCGGSKGGCGSCGCSQSSCC
                                     ::  : .  :.::.:   : . .: ..:::
NP_114                       MTCCQTSFCGYPSFSISGTCGSS---CCQPSCCETSCC
                                     10        20           30     

     120              130       140       150       160       170  
pF1KE0 KP-CCCSSGCG------SSCCQSSCCKPCCCQSSCCVPVCCQSSCCKPCCCQSNCCVPVC
       .:  : .: ::      :. :.::::.: ::..::: : ::..:::.: ::: . :   :
NP_114 QPRSCQTSFCGFPSFSTSGTCSSSCCQPSCCETSCCQPSCCETSCCQPSCCQISSCGTGC
          40        50        60        70        80        90     

                                                                   
pF1KE0 CQCKI                                                       
                                                                   
NP_114 GIGGGISYGQEGSSGAVSTRIRWCRPDSRVEGTYLPPCCVVSCTPPSCCQLHHAQASCCR
         100       110       120       130       140       150     

>>NP_112228 (OMIM: 608820) keratin-associated protein 1-  (167 aa)
 initn: 675 init1: 200 opt: 303  Z-score: 196.4  bits: 42.8 E(85289): 0.00033
Smith-Waterman score: 329; 50.6% identity (63.6% similar) in 77 aa overlap (110-174:2-77)

      80        90       100       110       120        130        
pF1KE0 SCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQSSCCKPCCCSSG-CGSSCCQSSCC
                                     .: :. : :  : : .:: ::::::: :::
NP_112                              MTC-CQTSFCGYPSCSTSGTCGSSCCQPSCC
                                             10        20        30

      140        150                 160       170                 
pF1KE0 KPCCCQSSCC-VPVC----------CQSSCCKPCCCQSNCCVPVCCQCKI          
       .  ::: ::: .  :          :.::::.: ::...:: : :::             
NP_112 ETSCCQPSCCQTSFCGFPSFSTSGTCSSSCCQPSCCETSCCQPSCCQTSSCGTGCGIGGG
               40        50        60        70        80        90

NP_112 IGYGQEGSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAEASCCRPSYCG
              100       110       120       130       140       150

>>NP_112229 (OMIM: 608819) keratin-associated protein 1-  (177 aa)
 initn: 544 init1: 217 opt: 270  Z-score: 178.4  bits: 39.5 E(85289): 0.0034
Smith-Waterman score: 342; 47.3% identity (62.6% similar) in 91 aa overlap (91-174:4-87)

               70        80        90       100       110       120
pF1KE0 CCCKPVCSWVPACSCTSCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQSSCCK
                                     :  :  :  ::. :    :.::   ::::.
NP_112                            MACCQTSFCGFPSCSTS----GTCG---SSCCQ
                                          10            20         

               130       140        150            160       170   
pF1KE0 PCCC-SSGCGSSCCQSSCCKPCCCQSSCC-VPV-----CCQSSCCKPCCCQSNCCVPVCC
       : :: .:.:   ::..:::.: :::.: :  :       :.::::.: ::...:: : : 
NP_112 PSCCETSSCQPRCCETSCCQPSCCQTSFCGFPSFSTGGTCDSSCCQPSCCETSCCQPSCY
         30        40        50        60        70        80      

                                                                   
pF1KE0 QCKI                                                        
       :                                                           
NP_112 QTSSCGTGCGIGGGIGYGQEGSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPSCCQL
         90       100       110       120       130       140      

>>NP_000418 (OMIM: 152445,604117) loricrin [Homo sapiens  (312 aa)
 initn: 435 init1: 186 opt: 271  Z-score: 176.8  bits: 40.0 E(85289): 0.0041
Smith-Waterman score: 271; 41.6% identity (53.0% similar) in 149 aa overlap (5-141:94-240)

                                         10           20           
pF1KE0                           MGCCGCSRGCGSGC---GGCGSSC---GGCGSGC
                                     : : : ::::   :: ::.:   :: ::. 
NP_000 CGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSG
            70        80        90       100       110       120   

       30           40        50        60        70        80     
pF1KE0 GGCG---SGRGGCGSGCGGCSSSCGGCGSRCYVPVCCCKPVCSWVPACSCTSCGSCGGSK
       :: :   :: :: ..: .:: :: ::  :   :       : :   . . ..: : ::  
NP_000 GGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGG--
           130       140       150       160       170       180   

          90       100       110       120          130       140  
pF1KE0 GGCGSCGGSKGGCGSCGGSKGGCGSCGCSQSSCCKPCCC---SSGCGSSCCQSSCCKPCC
       :: . :: : :: :  :::.:: ::   :...  .  :    : : :::   .:  . : 
NP_000 GGGSVCGYSGGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGCF
             190       200       210       220       230       240 

            150       160       170                                
pF1KE0 CQSSCCVPVCCQSSCCKPCCCQSNCCVPVCCQCKI                         
                                                                   
NP_000 SSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGGSGSGKGVPICHQT
             250       260       270       280       290       300 

>>XP_016878164 (OMIM: 612454) PREDICTED: multiple epider  (854 aa)
 initn: 194 init1: 118 opt: 275  Z-score: 175.1  bits: 41.2 E(85289): 0.0051
Smith-Waterman score: 287; 32.2% identity (50.3% similar) in 199 aa overlap (2-174:81-270)

                                            10        20           
pF1KE0                              MGCCGCSRGCGSGCGGCGSSC--GGCGSGCG
                                     : : :. :  ::   :. ::  :  :.:: 
XP_016 RLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPG-WSG-HHCNESCPVGYYGDGCQ
               60        70        80         90        100        

       30         40        50        60           70        80    
pF1KE0 -GCGSGRGG-CGSGCGGCSSSCGGCGSRCYVPVCCCK---PVCSWVPACSCTSCGSCGGS
         :    :. : :  :::. . :  :  : :  :      : :: .  :::.. :.:.  
XP_016 LPCTCQNGADCHSITGGCTCAPGFMGEVCAVS-CAAGTYGPNCSSI--CSCNNGGTCSPV
      110       120       130       140        150         160     

           90         100          110       120            130    
pF1KE0 KGGCGSCGGSKG-GCG-SC-GGSKG-GCG-SCGCSQSSCCKP----CCCSSG-CGSSC--
        :.:    : .:  :   : .:. : .:. :: :.... :.:    : :. :  :..:  
XP_016 DGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCEL
         170       180       190       200       210       220     

                  140        150       160       170               
pF1KE0 -CQS-----SCCKPC-CCQSSCCVPVCCQSSCCKPCCCQSNCCVPVCCQCKI        
        : .     .: . : : ... : ::   . ::  :    .  .:. :.           
XP_016 PCPDGTFGLNCSEHCDCSHADGCDPVT--GHCC--CLAGWTGNLPLLCHHPGIRCDSTCP
         230       240       250           260       270       280 

XP_016 PGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVH
             290       300       310       320       330       340 

>>XP_016878163 (OMIM: 612454) PREDICTED: multiple epider  (854 aa)
 initn: 194 init1: 118 opt: 275  Z-score: 175.1  bits: 41.2 E(85289): 0.0051
Smith-Waterman score: 287; 32.2% identity (50.3% similar) in 199 aa overlap (2-174:81-270)

                                            10        20           
pF1KE0                              MGCCGCSRGCGSGCGGCGSSC--GGCGSGCG
                                     : : :. :  ::   :. ::  :  :.:: 
XP_016 RLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPG-WSG-HHCNESCPVGYYGDGCQ
               60        70        80         90        100        

       30         40        50        60           70        80    
pF1KE0 -GCGSGRGG-CGSGCGGCSSSCGGCGSRCYVPVCCCK---PVCSWVPACSCTSCGSCGGS
         :    :. : :  :::. . :  :  : :  :      : :: .  :::.. :.:.  
XP_016 LPCTCQNGADCHSITGGCTCAPGFMGEVCAVS-CAAGTYGPNCSSI--CSCNNGGTCSPV
      110       120       130       140        150         160     

           90         100          110       120            130    
pF1KE0 KGGCGSCGGSKG-GCG-SC-GGSKG-GCG-SCGCSQSSCCKP----CCCSSG-CGSSC--
        :.:    : .:  :   : .:. : .:. :: :.... :.:    : :. :  :..:  
XP_016 DGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCEL
         170       180       190       200       210       220     

                  140        150       160       170               
pF1KE0 -CQS-----SCCKPC-CCQSSCCVPVCCQSSCCKPCCCQSNCCVPVCCQCKI        
        : .     .: . : : ... : ::   . ::  :    .  .:. :.           
XP_016 PCPDGTFGLNCSEHCDCSHADGCDPVT--GHCC--CLAGWTGNLPLLCHHPGIRCDSTCP
         230       240       250           260       270       280 

XP_016 PGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVH
             290       300       310       320       330       340 

>>XP_016878162 (OMIM: 612454) PREDICTED: multiple epider  (1021 aa)
 initn: 166 init1: 118 opt: 275  Z-score: 174.5  bits: 41.3 E(85289): 0.0056
Smith-Waterman score: 296; 32.2% identity (47.9% similar) in 211 aa overlap (2-174:377-582)

                                            10        20           
pF1KE0                              MGCCGCSRGCGSGCGGCGSSC--GGCGSGCG
                                     : : :. :  ::   :. ::  :  :.:: 
XP_016 RLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPG-WSG-HHCNESCPVGYYGDGCQ
        350       360       370       380         390       400    

       30         40        50        60           70        80    
pF1KE0 -GCGSGRGG-CGSGCGGCSSSCGGCGSRCYVPVCCCK---PVCSWVPACSCTSCGSCGGS
         :    :. : :  :::. . :  :  : :  :      : :: .  :::.. :.:.  
XP_016 LPCTCQNGADCHSITGGCTCAPGFMGEVCAVS-CAAGTYGPNCSSI--CSCNNGGTCSPV
          410       420       430        440         450       460 

           90         100          110       120            130    
pF1KE0 KGGCGSCGGSKG-GCG-SC-GGSKG-GCG-SCGCSQSSCCKP----CCCSSG-CGSSC--
        :.:    : .:  :   : .:. : .:. :: :.... :.:    : :. :  :..:  
XP_016 DGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCEL
             470       480       490       500       510       520 

                  140        150                   160       170   
pF1KE0 -CQS-----SCCKPC-CCQSSCCVPV----CCQS--------SCCKPCCCQSNCCVPVCC
        : .     .: . : : ... : ::    :: .        : : :     :: :   :
XP_016 PCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSC
             530       540       550       560       570       580 

                                                                   
pF1KE0 QCKI                                                        
       .                                                           
XP_016 ENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICEC
             590       600       610       620       630       640 

>>XP_016878161 (OMIM: 612454) PREDICTED: multiple epider  (1044 aa)
 initn: 166 init1: 118 opt: 275  Z-score: 174.4  bits: 41.3 E(85289): 0.0056
Smith-Waterman score: 296; 32.2% identity (47.9% similar) in 211 aa overlap (2-174:377-582)

                                            10        20           
pF1KE0                              MGCCGCSRGCGSGCGGCGSSC--GGCGSGCG
                                     : : :. :  ::   :. ::  :  :.:: 
XP_016 RLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPG-WSG-HHCNESCPVGYYGDGCQ
        350       360       370       380         390       400    

       30         40        50        60           70        80    
pF1KE0 -GCGSGRGG-CGSGCGGCSSSCGGCGSRCYVPVCCCK---PVCSWVPACSCTSCGSCGGS
         :    :. : :  :::. . :  :  : :  :      : :: .  :::.. :.:.  
XP_016 LPCTCQNGADCHSITGGCTCAPGFMGEVCAVS-CAAGTYGPNCSSI--CSCNNGGTCSPV
          410       420       430        440         450       460 

           90         100          110       120            130    
pF1KE0 KGGCGSCGGSKG-GCG-SC-GGSKG-GCG-SCGCSQSSCCKP----CCCSSG-CGSSC--
        :.:    : .:  :   : .:. : .:. :: :.... :.:    : :. :  :..:  
XP_016 DGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCEL
             470       480       490       500       510       520 

                  140        150                   160       170   
pF1KE0 -CQS-----SCCKPC-CCQSSCCVPV----CCQS--------SCCKPCCCQSNCCVPVCC
        : .     .: . : : ... : ::    :: .        : : :     :: :   :
XP_016 PCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSC
             530       540       550       560       570       580 

                                                                   
pF1KE0 QCKI                                                        
       .                                                           
XP_016 ENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICEC
             590       600       610       620       630       640 




177 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 20:22:23 2016 done: Thu Nov  3 20:22:24 2016
 Total Scan time:  4.920 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]
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