Result of FASTA (omim) for pF1KA0522
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0522, 1488 aa
  1>>>pF1KA0522 1488 - 1488 aa - 1488 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 17.2425+/-0.000483; mu= -32.4204+/- 0.030
 mean_var=765.0109+/-160.676, 0's: 0 Z-trim(125.1): 160  B-trim: 926 in 1/61
 Lambda= 0.046370
 statistics sampled from 47953 (48146) to 47953 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.8), E-opt: 0.2 (0.565), width:  16
 Scan time: 18.940

The best scores are:                                      opt bits E(85289)
NP_001104595 (OMIM: 300522,300551,309530) IQ motif (1488) 10335 707.9 1.5e-202
XP_016884848 (OMIM: 300522,300551,309530) PREDICTE (1478) 8794 604.8 1.6e-171
XP_006724642 (OMIM: 300522,300551,309530) PREDICTE (1520) 8787 604.3 2.3e-171
XP_011529075 (OMIM: 300522,300551,309530) PREDICTE (1251) 8684 597.4 2.4e-169
XP_006724643 (OMIM: 300522,300551,309530) PREDICTE (1283) 8683 597.3 2.5e-169
XP_016884849 (OMIM: 300522,300551,309530) PREDICTE (1322) 8679 597.1 3.1e-169
XP_011529076 (OMIM: 300522,300551,309530) PREDICTE (1222) 6351 441.3 2.2e-122
XP_006724645 (OMIM: 300522,300551,309530) PREDICTE (1212) 6339 440.5 3.9e-122
XP_006724644 (OMIM: 300522,300551,309530) PREDICTE (1244) 6323 439.4 8.3e-122
XP_006724646 (OMIM: 300522,300551,309530) PREDICTE (1200) 6234 433.5  5e-120
XP_006724647 (OMIM: 300522,300551,309530) PREDICTE (1186) 6223 432.7 8.2e-120
NP_055890 (OMIM: 300522,300551,309530) IQ motif an ( 949) 6119 425.7 8.6e-118
XP_011529079 (OMIM: 300522,300551,309530) PREDICTE (1126) 5849 407.7 2.7e-112
XP_011529078 (OMIM: 300522,300551,309530) PREDICTE (1130) 5844 407.4 3.4e-112
XP_016863070 (OMIM: 610166) PREDICTED: IQ motif an (1212) 2955 214.1 5.4e-54
XP_016863071 (OMIM: 610166) PREDICTED: IQ motif an (1207) 2011 151.0 5.6e-35
XP_011532606 (OMIM: 610166) PREDICTED: IQ motif an (1222) 1960 147.5   6e-34
XP_011532608 (OMIM: 610166) PREDICTED: IQ motif an (1129) 1955 147.2 7.1e-34
XP_011532609 (OMIM: 610166) PREDICTED: IQ motif an (1129) 1942 146.3 1.3e-33
XP_011532607 (OMIM: 610166) PREDICTED: IQ motif an (1132) 1942 146.3 1.3e-33
NP_001127854 (OMIM: 610166) IQ motif and SEC7 doma (1114) 1939 146.1 1.5e-33
XP_011532610 (OMIM: 610166) PREDICTED: IQ motif an (1128) 1937 146.0 1.6e-33
XP_011532614 (OMIM: 610166) PREDICTED: IQ motif an (1006) 1883 142.3 1.8e-32
XP_011532613 (OMIM: 610166) PREDICTED: IQ motif an (1006) 1883 142.3 1.8e-32
XP_011532616 (OMIM: 610166) PREDICTED: IQ motif an (1006) 1883 142.3 1.8e-32
XP_011532615 (OMIM: 610166) PREDICTED: IQ motif an (1006) 1883 142.3 1.8e-32
XP_011532612 (OMIM: 610166) PREDICTED: IQ motif an (1030) 1767 134.6   4e-30
XP_011519263 (OMIM: 612118) PREDICTED: IQ motif an ( 879) 1754 133.7 6.5e-30
NP_001164209 (OMIM: 612118) IQ motif and SEC7 doma (1182) 1754 133.8 8.2e-30
NP_055684 (OMIM: 610166) IQ motif and SEC7 domain- ( 963) 1745 133.1 1.1e-29
NP_056047 (OMIM: 612118) IQ motif and SEC7 domain- ( 759) 1708 130.5 4.8e-29
XP_011519260 (OMIM: 612118) PREDICTED: IQ motif an (1063) 1710 130.8 5.8e-29
XP_016874799 (OMIM: 612118) PREDICTED: IQ motif an (1041) 1708 130.6 6.2e-29
XP_016874800 (OMIM: 612118) PREDICTED: IQ motif an (1041) 1708 130.6 6.2e-29
XP_011519262 (OMIM: 612118) PREDICTED: IQ motif an (1062) 1708 130.6 6.3e-29
XP_011519261 (OMIM: 612118) PREDICTED: IQ motif an (1062) 1708 130.6 6.3e-29
XP_011532617 (OMIM: 610166) PREDICTED: IQ motif an ( 814) 1690 129.4 1.2e-28
NP_001317548 (OMIM: 610166) IQ motif and SEC7 doma ( 814) 1690 129.4 1.2e-28
XP_006723536 (OMIM: 602488) PREDICTED: cytohesin-2 ( 394)  517 50.7 2.8e-05
NP_004219 (OMIM: 602488) cytohesin-2 isoform 2 [Ho ( 399)  517 50.7 2.8e-05
NP_059431 (OMIM: 602488) cytohesin-2 isoform 1 [Ho ( 400)  517 50.7 2.8e-05
XP_006723535 (OMIM: 602488) PREDICTED: cytohesin-2 ( 421)  517 50.7 2.9e-05
XP_011515744 (OMIM: 604141) PREDICTED: brefeldin A (1649)  537 52.4 3.4e-05
XP_005251193 (OMIM: 604141) PREDICTED: brefeldin A (1800)  537 52.5 3.7e-05
XP_005251192 (OMIM: 604141) PREDICTED: brefeldin A (1843)  537 52.5 3.8e-05
NP_006412 (OMIM: 604141) brefeldin A-inhibited gua (1849)  537 52.5 3.8e-05
XP_005251191 (OMIM: 604141) PREDICTED: brefeldin A (1849)  537 52.5 3.8e-05
XP_011523777 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322)  496 49.2 6.2e-05
XP_011523778 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322)  496 49.2 6.2e-05
XP_016880827 (OMIM: 182115) PREDICTED: cytohesin-1 ( 338)  496 49.2 6.5e-05


>>NP_001104595 (OMIM: 300522,300551,309530) IQ motif and  (1488 aa)
 initn: 10335 init1: 10335 opt: 10335  Z-score: 3757.2  bits: 707.9 E(85289): 1.5e-202
Smith-Waterman score: 10335; 100.0% identity (100.0% similar) in 1488 aa overlap (1-1488:1-1488)

               10        20        30        40        50        60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 NSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 ASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 YRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 ARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALN
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 CHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 GRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 DSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 PLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 LREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGF
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA0 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA0 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA0 KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYS
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KA0 FRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESI
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KA0 AEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGAL
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KA0 SSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSN
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KA0 SSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDG
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KA0 QSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KA0 HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPA
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KA0 HKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPL
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480        
pF1KA0 PPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
       ::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
             1450      1460      1470      1480        

>>XP_016884848 (OMIM: 300522,300551,309530) PREDICTED: I  (1478 aa)
 initn: 8673 init1: 8673 opt: 8794  Z-score: 3200.1  bits: 604.8 E(85289): 1.6e-171
Smith-Waterman score: 10239; 99.3% identity (99.3% similar) in 1488 aa overlap (1-1488:1-1478)

               10        20        30        40        50        60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::     
XP_016 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQR-----
              190       200       210       220       230          

              250       260       270       280       290       300
pF1KA0 NSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQP
            .::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -----NVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQP
              240       250       260       270       280       290

              310       320       330       340       350       360
pF1KA0 ASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQ
              300       310       320       330       340       350

              370       380       390       400       410       420
pF1KA0 YRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAG
              360       370       380       390       400       410

              430       440       450       460       470       480
pF1KA0 ARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALN
              420       430       440       450       460       470

              490       500       510       520       530       540
pF1KA0 CHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQ
              480       490       500       510       520       530

              550       560       570       580       590       600
pF1KA0 GRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPS
              540       550       560       570       580       590

              610       620       630       640       650       660
pF1KA0 DSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG
              600       610       620       630       640       650

              670       680       690       700       710       720
pF1KA0 PLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDS
              660       670       680       690       700       710

              730       740       750       760       770       780
pF1KA0 LREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGF
              720       730       740       750       760       770

              790       800       810       820       830       840
pF1KA0 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF
              780       790       800       810       820       830

              850       860       870       880       890       900
pF1KA0 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV
              840       850       860       870       880       890

              910       920       930       940       950       960
pF1KA0 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG
              900       910       920       930       940       950

              970       980       990      1000      1010      1020
pF1KA0 KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYS
              960       970       980       990      1000      1010

             1030      1040      1050      1060      1070      1080
pF1KA0 FRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESI
             1020      1030      1040      1050      1060      1070

             1090      1100      1110      1120      1130      1140
pF1KA0 AEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGAL
             1080      1090      1100      1110      1120      1130

             1150      1160      1170      1180      1190      1200
pF1KA0 SSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSN
             1140      1150      1160      1170      1180      1190

             1210      1220      1230      1240      1250      1260
pF1KA0 SSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDG
             1200      1210      1220      1230      1240      1250

             1270      1280      1290      1300      1310      1320
pF1KA0 QSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR
             1260      1270      1280      1290      1300      1310

             1330      1340      1350      1360      1370      1380
pF1KA0 HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPA
             1320      1330      1340      1350      1360      1370

             1390      1400      1410      1420      1430      1440
pF1KA0 HKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPL
             1380      1390      1400      1410      1420      1430

             1450      1460      1470      1480        
pF1KA0 PPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
       ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
             1440      1450      1460      1470        

>>XP_006724642 (OMIM: 300522,300551,309530) PREDICTED: I  (1520 aa)
 initn: 10321 init1: 8677 opt: 8787  Z-score: 3197.4  bits: 604.3 E(85289): 2.3e-171
Smith-Waterman score: 10261; 97.9% identity (97.9% similar) in 1520 aa overlap (1-1488:1-1520)

               10        20        30        40        50        60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
              190       200       210       220       230       240

                                              250       260        
pF1KA0 NSRTV--------------------------------SVEGDAPGSDLSTAVDSPGSQPP
       :::::                                :::::::::::::::::::::::
XP_006 NSRTVRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGSQPP
              250       260       270       280       290       300

      270       280       290       300       310       320        
pF1KA0 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
              310       320       330       340       350       360

      330       340       350       360       370       380        
pF1KA0 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
              370       380       390       400       410       420

      390       400       410       420       430       440        
pF1KA0 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
              430       440       450       460       470       480

      450       460       470       480       490       500        
pF1KA0 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
              490       500       510       520       530       540

      510       520       530       540       550       560        
pF1KA0 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
              550       560       570       580       590       600

      570       580       590       600       610       620        
pF1KA0 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
              610       620       630       640       650       660

      630       640       650       660       670       680        
pF1KA0 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
              670       680       690       700       710       720

      690       700       710       720       730       740        
pF1KA0 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
              730       740       750       760       770       780

      750       760       770       780       790       800        
pF1KA0 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
              790       800       810       820       830       840

      810       820       830       840       850       860        
pF1KA0 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
              850       860       870       880       890       900

      870       880       890       900       910       920        
pF1KA0 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
              910       920       930       940       950       960

      930       940       950       960       970       980        
pF1KA0 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
              970       980       990      1000      1010      1020

      990      1000      1010      1020      1030      1040        
pF1KA0 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
             1030      1040      1050      1060      1070      1080

     1050      1060      1070      1080      1090      1100        
pF1KA0 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
             1090      1100      1110      1120      1130      1140

     1110      1120      1130      1140      1150      1160        
pF1KA0 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
             1150      1160      1170      1180      1190      1200

     1170      1180      1190      1200      1210      1220        
pF1KA0 SVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQA
             1210      1220      1230      1240      1250      1260

     1230      1240      1250      1260      1270      1280        
pF1KA0 SASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQP
             1270      1280      1290      1300      1310      1320

     1290      1300      1310      1320      1330      1340        
pF1KA0 SLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAG
             1330      1340      1350      1360      1370      1380

     1350      1360      1370      1380      1390      1400        
pF1KA0 GHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGS
             1390      1400      1410      1420      1430      1440

     1410      1420      1430      1440      1450      1460        
pF1KA0 RPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPG
             1450      1460      1470      1480      1490      1500

     1470      1480        
pF1KA0 TANPPSANPKAKPSRISTVV
       ::::::::::::::::::::
XP_006 TANPPSANPKAKPSRISTVV
             1510      1520

>>XP_011529075 (OMIM: 300522,300551,309530) PREDICTED: I  (1251 aa)
 initn: 8684 init1: 8684 opt: 8684  Z-score: 3161.4  bits: 597.4 E(85289): 2.4e-169
Smith-Waterman score: 8684; 99.8% identity (99.9% similar) in 1246 aa overlap (243-1488:6-1251)

            220       230       240       250       260       270  
pF1KA0 SSPGAGGGHSTSTSTSPATTLQRKSDGENSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLS
                                     :. :::::::::::::::::::::::::::
XP_011                          MEPPGRSSSVEGDAPGSDLSTAVDSPGSQPPYRLS
                                        10        20        30     

            280       290       300       310       320       330  
pF1KA0 QLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDK
          40        50        60        70        80        90     

            340       350       360       370       380       390  
pF1KA0 KVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQF
         100       110       120       130       140       150     

            400       410       420       430       440       450  
pF1KA0 SFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGE
         160       170       180       190       200       210     

            460       470       480       490       500       510  
pF1KA0 FSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATS
         220       230       240       250       260       270     

            520       530       540       550       560       570  
pF1KA0 FSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGT
         280       290       300       310       320       330     

            580       590       600       610       620       630  
pF1KA0 RRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTL
         340       350       360       370       380       390     

            640       650       660       670       680       690  
pF1KA0 KHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSD
         400       410       420       430       440       450     

            700       710       720       730       740       750  
pF1KA0 GGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVV
         460       470       480       490       500       510     

            760       770       780       790       800       810  
pF1KA0 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK
         520       530       540       550       560       570     

            820       830       840       850       860       870  
pF1KA0 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV
         580       590       600       610       620       630     

            880       890       900       910       920       930  
pF1KA0 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI
         640       650       660       670       680       690     

            940       950       960       970       980       990  
pF1KA0 YQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGL
         700       710       720       730       740       750     

           1000      1010      1020      1030      1040      1050  
pF1KA0 HQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPG
         760       770       780       790       800       810     

           1060      1070      1080      1090      1100      1110  
pF1KA0 GERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGA
         820       830       840       850       860       870     

           1120      1130      1140      1150      1160      1170  
pF1KA0 KDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVIS
         880       890       900       910       920       930     

           1180      1190      1200      1210      1220      1230  
pF1KA0 SPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASS
         940       950       960       970       980       990     

           1240      1250      1260      1270      1280      1290  
pF1KA0 SSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPP
        1000      1010      1020      1030      1040      1050     

           1300      1310      1320      1330      1340      1350  
pF1KA0 PPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQ
        1060      1070      1080      1090      1100      1110     

           1360      1370      1380      1390      1400      1410  
pF1KA0 FAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPG
        1120      1130      1140      1150      1160      1170     

           1420      1430      1440      1450      1460      1470  
pF1KA0 GSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANP
        1180      1190      1200      1210      1220      1230     

           1480        
pF1KA0 PSANPKAKPSRISTVV
       ::::::::::::::::
XP_011 PSANPKAKPSRISTVV
        1240      1250 

>>XP_006724643 (OMIM: 300522,300551,309530) PREDICTED: I  (1283 aa)
 initn: 8677 init1: 8677 opt: 8683  Z-score: 3160.9  bits: 597.3 E(85289): 2.5e-169
Smith-Waterman score: 8683; 97.7% identity (98.4% similar) in 1280 aa overlap (211-1488:6-1283)

              190       200       210       220       230       240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
                                     :::   :  .:.      :. .:.  .   
XP_006                          MEPPGRSSRSTA--SHTLHQYCCPTQVLDSMKLTP
                                        10          20        30   

                250       260       270       280       290        
pF1KA0 NSRTV--SVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARL
       ..: .  :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SGRLAESSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARL
            40        50        60        70        80        90   

      300       310       320       330       340       350        
pF1KA0 QPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAF
           100       110       120       130       140       150   

      360       370       380       390       400       410        
pF1KA0 RQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAM
           160       170       180       190       200       210   

      420       430       440       450       460       470        
pF1KA0 AGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEA
           220       230       240       250       260       270   

      480       490       500       510       520       530        
pF1KA0 LNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPP
           280       290       300       310       320       330   

      540       550       560       570       580       590        
pF1KA0 PQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEP
           340       350       360       370       380       390   

      600       610       620       630       640       650        
pF1KA0 PSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAP
           400       410       420       430       440       450   

      660       670       680       690       700       710        
pF1KA0 PGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSR
           460       470       480       490       500       510   

      720       730       740       750       760       770        
pF1KA0 DSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIER
           520       530       540       550       560       570   

      780       790       800       810       820       830        
pF1KA0 GFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALR
           580       590       600       610       620       630   

      840       850       860       870       880       890        
pF1KA0 KFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSP
           640       650       660       670       680       690   

      900       910       920       930       940       950        
pF1KA0 SVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMI
           700       710       720       730       740       750   

      960       970       980       990      1000      1010        
pF1KA0 VGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVT
           760       770       780       790       800       810   

     1020      1030      1040      1050      1060      1070        
pF1KA0 YSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRE
           820       830       840       850       860       870   

     1080      1090      1100      1110      1120      1130        
pF1KA0 SIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRG
           880       890       900       910       920       930   

     1140      1150      1160      1170      1180      1190        
pF1KA0 ALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPV
           940       950       960       970       980       990   

     1200      1210      1220      1230      1240      1250        
pF1KA0 SNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLP
          1000      1010      1020      1030      1040      1050   

     1260      1270      1280      1290      1300      1310        
pF1KA0 DGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGP
          1060      1070      1080      1090      1100      1110   

     1320      1330      1340      1350      1360      1370        
pF1KA0 HRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHP
          1120      1130      1140      1150      1160      1170   

     1380      1390      1400      1410      1420      1430        
pF1KA0 PAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYP
          1180      1190      1200      1210      1220      1230   

     1440      1450      1460      1470      1480        
pF1KA0 PLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
          1240      1250      1260      1270      1280   

>>XP_016884849 (OMIM: 300522,300551,309530) PREDICTED: I  (1322 aa)
 initn: 8677 init1: 8677 opt: 8679  Z-score: 3159.3  bits: 597.1 E(85289): 3.1e-169
Smith-Waterman score: 8679; 98.2% identity (98.8% similar) in 1270 aa overlap (221-1488:53-1322)

              200       210       220       230       240          
pF1KA0 AVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGENSRTV--SVE
                                     :.      :. .:.  .   ..: .  :::
XP_016 PPSPTLPLPSLPVSLSVSLCLLLSLRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVE
             30        40        50        60        70        80  

      250       260       270       280       290       300        
pF1KA0 GDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQ
             90       100       110       120       130       140  

      310       320       330       340       350       360        
pF1KA0 EEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFE
            150       160       170       180       190       200  

      370       380       390       400       410       420        
pF1KA0 RLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLER
            210       220       230       240       250       260  

      430       440       450       460       470       480        
pF1KA0 GLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMS
            270       280       290       300       310       320  

      490       500       510       520       530       540        
pF1KA0 EEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAP
            330       340       350       360       370       380  

      550       560       570       580       590       600        
pF1KA0 APLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSD
            390       400       410       420       430       440  

      610       620       630       640       650       660        
pF1KA0 RSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNS
            450       460       470       480       490       500  

      670       680       690       700       710       720        
pF1KA0 GTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATG
            510       520       530       540       550       560  

      730       740       750       760       770       780        
pF1KA0 LCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGV
            570       580       590       600       610       620  

      790       800       810       820       830       840        
pF1KA0 AHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQG
            630       640       650       660       670       680  

      850       860       870       880       890       900        
pF1KA0 EAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKL
            690       700       710       720       730       740  

      910       920       930       940       950       960        
pF1KA0 DDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLP
            750       760       770       780       790       800  

      970       980       990      1000      1010      1020        
pF1KA0 HRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLV
            810       820       830       840       850       860  

     1030      1040      1050      1060      1070      1080        
pF1KA0 EMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEK
            870       880       890       900       910       920  

     1090      1100      1110      1120      1130      1140        
pF1KA0 YRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLS
            930       940       950       960       970       980  

     1150      1160      1170      1180      1190      1200        
pF1KA0 DAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSL
            990      1000      1010      1020      1030      1040  

     1210      1220      1230      1240      1250      1260        
pF1KA0 FGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALH
           1050      1060      1070      1080      1090      1100  

     1270      1280      1290      1300      1310      1320        
pF1KA0 AQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPV
           1110      1120      1130      1140      1150      1160  

     1330      1340      1350      1360      1370      1380        
pF1KA0 PGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHF
           1170      1180      1190      1200      1210      1220  

     1390      1400      1410      1420      1430      1440        
pF1KA0 IFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTP
           1230      1240      1250      1260      1270      1280  

     1450      1460      1470      1480        
pF1KA0 HSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
       ::::::::::::::::::::::::::::::::::::::::
XP_016 HSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
           1290      1300      1310      1320  

>>XP_011529076 (OMIM: 300522,300551,309530) PREDICTED: I  (1222 aa)
 initn: 7864 init1: 6220 opt: 6351  Z-score: 2318.1  bits: 441.3 E(85289): 2.2e-122
Smith-Waterman score: 7825; 96.1% identity (96.6% similar) in 1220 aa overlap (1-1185:1-1220)

               10        20        30        40        50        60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
              190       200       210       220       230       240

                                              250       260        
pF1KA0 NSRTV--------------------------------SVEGDAPGSDLSTAVDSPGSQPP
       :::::                                :::::::::::::::::::::::
XP_011 NSRTVRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGSQPP
              250       260       270       280       290       300

      270       280       290       300       310       320        
pF1KA0 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
              310       320       330       340       350       360

      330       340       350       360       370       380        
pF1KA0 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
              370       380       390       400       410       420

      390       400       410       420       430       440        
pF1KA0 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
              430       440       450       460       470       480

      450       460       470       480       490       500        
pF1KA0 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
              490       500       510       520       530       540

      510       520       530       540       550       560        
pF1KA0 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
              550       560       570       580       590       600

      570       580       590       600       610       620        
pF1KA0 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
              610       620       630       640       650       660

      630       640       650       660       670       680        
pF1KA0 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
              670       680       690       700       710       720

      690       700       710       720       730       740        
pF1KA0 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
              730       740       750       760       770       780

      750       760       770       780       790       800        
pF1KA0 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
              790       800       810       820       830       840

      810       820       830       840       850       860        
pF1KA0 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
              850       860       870       880       890       900

      870       880       890       900       910       920        
pF1KA0 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
              910       920       930       940       950       960

      930       940       950       960       970       980        
pF1KA0 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
              970       980       990      1000      1010      1020

      990      1000      1010      1020      1030      1040        
pF1KA0 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
             1030      1040      1050      1060      1070      1080

     1050      1060      1070      1080      1090      1100        
pF1KA0 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
             1090      1100      1110      1120      1130      1140

     1110      1120      1130      1140      1150      1160        
pF1KA0 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
             1150      1160      1170      1180      1190      1200

     1170         1180      1190      1200      1210      1220     
pF1KA0 SV-ISSPRP--HQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPT
          .. :    :... :: :                                        
XP_011 RRRVGMPLELGHEKLLPPSPAL                                      
             1210      1220                                        

>>XP_006724645 (OMIM: 300522,300551,309530) PREDICTED: I  (1212 aa)
 initn: 7923 init1: 6214 opt: 6339  Z-score: 2313.8  bits: 440.5 E(85289): 3.9e-122
Smith-Waterman score: 7813; 96.5% identity (96.9% similar) in 1212 aa overlap (1-1180:1-1212)

               10        20        30        40        50        60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
              190       200       210       220       230       240

                                              250       260        
pF1KA0 NSRTV--------------------------------SVEGDAPGSDLSTAVDSPGSQPP
       :::::                                :::::::::::::::::::::::
XP_006 NSRTVRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGSQPP
              250       260       270       280       290       300

      270       280       290       300       310       320        
pF1KA0 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
              310       320       330       340       350       360

      330       340       350       360       370       380        
pF1KA0 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
              370       380       390       400       410       420

      390       400       410       420       430       440        
pF1KA0 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
              430       440       450       460       470       480

      450       460       470       480       490       500        
pF1KA0 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
              490       500       510       520       530       540

      510       520       530       540       550       560        
pF1KA0 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
              550       560       570       580       590       600

      570       580       590       600       610       620        
pF1KA0 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
              610       620       630       640       650       660

      630       640       650       660       670       680        
pF1KA0 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
              670       680       690       700       710       720

      690       700       710       720       730       740        
pF1KA0 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
              730       740       750       760       770       780

      750       760       770       780       790       800        
pF1KA0 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
              790       800       810       820       830       840

      810       820       830       840       850       860        
pF1KA0 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
              850       860       870       880       890       900

      870       880       890       900       910       920        
pF1KA0 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
              910       920       930       940       950       960

      930       940       950       960       970       980        
pF1KA0 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
              970       980       990      1000      1010      1020

      990      1000      1010      1020      1030      1040        
pF1KA0 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
             1030      1040      1050      1060      1070      1080

     1050      1060      1070      1080      1090      1100        
pF1KA0 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
             1090      1100      1110      1120      1130      1140

     1110      1120      1130      1140      1150      1160        
pF1KA0 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: 
XP_006 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIED
             1150      1160      1170      1180      1190      1200

     1170      1180      1190      1200      1210      1220        
pF1KA0 SVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQA
       . . .  :..:.                                                
XP_006 GCVWAKGPQRRL                                                
             1210                                                  

>>XP_006724644 (OMIM: 300522,300551,309530) PREDICTED: I  (1244 aa)
 initn: 7922 init1: 6213 opt: 6323  Z-score: 2307.8  bits: 439.4 E(85289): 8.3e-122
Smith-Waterman score: 7797; 97.3% identity (97.3% similar) in 1201 aa overlap (1-1169:1-1201)

               10        20        30        40        50        60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
              190       200       210       220       230       240

                                              250       260        
pF1KA0 NSRTV--------------------------------SVEGDAPGSDLSTAVDSPGSQPP
       :::::                                :::::::::::::::::::::::
XP_006 NSRTVRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGSQPP
              250       260       270       280       290       300

      270       280       290       300       310       320        
pF1KA0 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
              310       320       330       340       350       360

      330       340       350       360       370       380        
pF1KA0 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
              370       380       390       400       410       420

      390       400       410       420       430       440        
pF1KA0 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
              430       440       450       460       470       480

      450       460       470       480       490       500        
pF1KA0 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
              490       500       510       520       530       540

      510       520       530       540       550       560        
pF1KA0 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
              550       560       570       580       590       600

      570       580       590       600       610       620        
pF1KA0 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
              610       620       630       640       650       660

      630       640       650       660       670       680        
pF1KA0 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
              670       680       690       700       710       720

      690       700       710       720       730       740        
pF1KA0 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
              730       740       750       760       770       780

      750       760       770       780       790       800        
pF1KA0 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
              790       800       810       820       830       840

      810       820       830       840       850       860        
pF1KA0 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
              850       860       870       880       890       900

      870       880       890       900       910       920        
pF1KA0 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
              910       920       930       940       950       960

      930       940       950       960       970       980        
pF1KA0 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
              970       980       990      1000      1010      1020

      990      1000      1010      1020      1030      1040        
pF1KA0 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
             1030      1040      1050      1060      1070      1080

     1050      1060      1070      1080      1090      1100        
pF1KA0 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
             1090      1100      1110      1120      1130      1140

     1110      1120      1130      1140      1150      1160        
pF1KA0 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: 
XP_006 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEV
             1150      1160      1170      1180      1190      1200

     1170      1180      1190      1200      1210      1220        
pF1KA0 SVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQA
       :                                                           
XP_006 SQGRQLAKAAAGATYAFDAASWTRLEGLKSLDPQGPESSPINIF                
             1210      1220      1230      1240                    

>>XP_006724646 (OMIM: 300522,300551,309530) PREDICTED: I  (1200 aa)
 initn: 7757 init1: 6113 opt: 6234  Z-score: 2275.9  bits: 433.5 E(85289): 5e-120
Smith-Waterman score: 7708; 96.7% identity (97.0% similar) in 1193 aa overlap (1-1161:1-1193)

               10        20        30        40        50        60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
              190       200       210       220       230       240

                                              250       260        
pF1KA0 NSRTV--------------------------------SVEGDAPGSDLSTAVDSPGSQPP
       :::::                                :::::::::::::::::::::::
XP_006 NSRTVRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGSQPP
              250       260       270       280       290       300

      270       280       290       300       310       320        
pF1KA0 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
              310       320       330       340       350       360

      330       340       350       360       370       380        
pF1KA0 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
              370       380       390       400       410       420

      390       400       410       420       430       440        
pF1KA0 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
              430       440       450       460       470       480

      450       460       470       480       490       500        
pF1KA0 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
              490       500       510       520       530       540

      510       520       530       540       550       560        
pF1KA0 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
              550       560       570       580       590       600

      570       580       590       600       610       620        
pF1KA0 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
              610       620       630       640       650       660

      630       640       650       660       670       680        
pF1KA0 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
              670       680       690       700       710       720

      690       700       710       720       730       740        
pF1KA0 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
              730       740       750       760       770       780

      750       760       770       780       790       800        
pF1KA0 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
              790       800       810       820       830       840

      810       820       830       840       850       860        
pF1KA0 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
              850       860       870       880       890       900

      870       880       890       900       910       920        
pF1KA0 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
              910       920       930       940       950       960

      930       940       950       960       970       980        
pF1KA0 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
              970       980       990      1000      1010      1020

      990      1000      1010      1020      1030      1040        
pF1KA0 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
             1030      1040      1050      1060      1070      1080

     1050      1060      1070      1080      1090      1100        
pF1KA0 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
             1090      1100      1110      1120      1130      1140

     1110      1120      1130      1140      1150      1160        
pF1KA0 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
       :::::::::::::::::::::::::::::::::::::::::::  :. .: .:       
XP_006 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGVPGKTTSKSSSWGHLRI
             1150      1160      1170      1180      1190      1200

     1170      1180      1190      1200      1210      1220        
pF1KA0 SVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQA




1488 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 01:24:04 2016 done: Sat Nov  5 01:24:07 2016
 Total Scan time: 18.940 Total Display time:  0.750

Function used was FASTA [36.3.4 Apr, 2011]
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