Result of FASTA (omim) for pF1KB3134
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3134, 1230 aa
  1>>>pF1KB3134 1230 - 1230 aa - 1230 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 10.3561+/-0.000531; mu= -1.5741+/- 0.033
 mean_var=271.0442+/-55.201, 0's: 0 Z-trim(115.9): 307  B-trim: 72 in 1/49
 Lambda= 0.077903
 statistics sampled from 26257 (26613) to 26257 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.312), width:  16
 Scan time: 15.460

The best scores are:                                      opt bits E(85289)
NP_004013 (OMIM: 300376,300377,302045,310200) dyst (1230) 8129 928.6       0
XP_006724533 (OMIM: 300376,300377,302045,310200) P (3690) 8135 929.5       0
XP_016884817 (OMIM: 300376,300377,302045,310200) P (3672) 7942 907.8       0
XP_016884820 (OMIM: 300376,300377,302045,310200) P (1761) 6332 726.7 3.2e-208
NP_004004 (OMIM: 300376,300377,302045,310200) dyst (1225) 6326 725.9 3.9e-208
NP_004012 (OMIM: 300376,300377,302045,310200) dyst (1243) 6326 725.9 3.9e-208
XP_006724536 (OMIM: 300376,300377,302045,310200) P (3657) 6332 726.9 5.8e-208
XP_011543769 (OMIM: 300376,300377,302045,310200) P (3662) 6332 726.9 5.8e-208
XP_006724532 (OMIM: 300376,300377,302045,310200) P (3695) 6332 726.9 5.9e-208
XP_006724531 (OMIM: 300376,300377,302045,310200) P (3703) 6332 726.9 5.9e-208
NP_004003 (OMIM: 300376,300377,302045,310200) dyst (2341) 6326 726.1 6.5e-208
NP_004002 (OMIM: 300376,300377,302045,310200) dyst (2344) 6326 726.1 6.5e-208
NP_004001 (OMIM: 300376,300377,302045,310200) dyst (3562) 6326 726.2 9.1e-208
NP_000100 (OMIM: 300376,300377,302045,310200) dyst (3677) 6326 726.2 9.4e-208
NP_004000 (OMIM: 300376,300377,302045,310200) dyst (3681) 6326 726.2 9.4e-208
NP_003997 (OMIM: 300376,300377,302045,310200) dyst (3685) 6326 726.2 9.4e-208
NP_004011 (OMIM: 300376,300377,302045,310200) dyst (1115) 6302 723.2 2.3e-207
NP_004014 (OMIM: 300376,300377,302045,310200) dyst (1133) 6302 723.2 2.3e-207
XP_006724538 (OMIM: 300376,300377,302045,310200) P (3575) 6308 724.2 3.7e-207
XP_006724537 (OMIM: 300376,300377,302045,310200) P (3593) 6308 724.2 3.7e-207
XP_011543770 (OMIM: 300376,300377,302045,310200) P (3295) 5320 613.1 9.3e-174
XP_016866733 (OMIM: 128240) PREDICTED: utrophin is (3456) 4938 570.2 8.1e-161
NP_004005 (OMIM: 300376,300377,302045,310200) dyst ( 956) 4531 524.1 1.7e-147
NP_004009 (OMIM: 300376,300377,302045,310200) dyst ( 622) 4133 479.3 3.5e-134
XP_005267190 (OMIM: 128240) PREDICTED: utrophin is (3424) 4018 466.8 1.1e-129
XP_011534409 (OMIM: 128240) PREDICTED: utrophin is (3424) 4018 466.8 1.1e-129
XP_005267187 (OMIM: 128240) PREDICTED: utrophin is (3433) 4018 466.8 1.1e-129
XP_011534408 (OMIM: 128240) PREDICTED: utrophin is (3433) 4018 466.8 1.1e-129
NP_009055 (OMIM: 128240) utrophin [Homo sapiens]   (3433) 4018 466.8 1.1e-129
XP_005267184 (OMIM: 128240) PREDICTED: utrophin is (3438) 4018 466.8 1.1e-129
XP_016866732 (OMIM: 128240) PREDICTED: utrophin is (3468) 4018 466.8 1.1e-129
XP_011534404 (OMIM: 128240) PREDICTED: utrophin is (3469) 4018 466.8 1.1e-129
XP_011534403 (OMIM: 128240) PREDICTED: utrophin is (3469) 4018 466.8 1.1e-129
NP_004008 (OMIM: 300376,300377,302045,310200) dyst ( 604) 3940 457.6 1.2e-127
XP_006715623 (OMIM: 128240) PREDICTED: utrophin is ( 957) 3312 387.1  3e-106
XP_011534411 (OMIM: 128240) PREDICTED: utrophin is ( 988) 3309 386.8 3.8e-106
NP_001164655 (OMIM: 300052) dystrophin-related pro ( 879) 3290 384.6 1.5e-105
NP_001930 (OMIM: 300052) dystrophin-related protei ( 957) 3290 384.6 1.6e-105
XP_016884823 (OMIM: 300052) PREDICTED: dystrophin- ( 611) 2415 286.2 4.6e-76
NP_004006 (OMIM: 300376,300377,302045,310200) dyst ( 617) 2330 276.6 3.5e-73
NP_004007 (OMIM: 300376,300377,302045,310200) dyst ( 635) 2330 276.6 3.6e-73
NP_004010 (OMIM: 300376,300377,302045,310200) dyst ( 340) 2295 272.5 3.3e-72
XP_016884822 (OMIM: 300052) PREDICTED: dystrophin- ( 932) 2014 241.2 2.4e-62
XP_016866734 (OMIM: 128240) PREDICTED: utrophin is (2675) 1174 147.1 1.5e-33
NP_068707 (OMIM: 602415) dystrobrevin beta isoform ( 627)  687 92.0 1.4e-17
NP_899204 (OMIM: 602415) dystrobrevin beta isoform ( 609)  668 89.8 5.9e-17
NP_001307865 (OMIM: 602415) dystrobrevin beta isof ( 625)  668 89.8   6e-17
NP_149159 (OMIM: 602415) dystrobrevin beta isoform ( 597)  656 88.5 1.5e-16
XP_016881072 (OMIM: 601239,604169) PREDICTED: dyst ( 712)  654 88.3   2e-16
XP_005264239 (OMIM: 602415) PREDICTED: dystrobrevi ( 602)  641 86.8 4.8e-16


>>NP_004013 (OMIM: 300376,300377,302045,310200) dystroph  (1230 aa)
 initn: 8129 init1: 8129 opt: 8129  Z-score: 4952.9  bits: 928.6 E(85289):    0
Smith-Waterman score: 8129; 99.9% identity (100.0% similar) in 1230 aa overlap (1-1230:1-1230)

               10        20        30        40        50        60
pF1KB3 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
NP_004 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPASSPQLSHDDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPASSPQLSHDDT
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 HSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQ
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 ILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSP
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB3 RDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSS
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB3 PSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGH
             1150      1160      1170      1180      1190      1200

             1210      1220      1230
pF1KB3 NVGSLFHMADDLGRAMESLVSVMTDEEGAE
       ::::::::::::::::::::::::::::::
NP_004 NVGSLFHMADDLGRAMESLVSVMTDEEGAE
             1210      1220      1230

>>XP_006724533 (OMIM: 300376,300377,302045,310200) PREDI  (3690 aa)
 initn: 8135 init1: 8135 opt: 8135  Z-score: 4949.6  bits: 929.5 E(85289):    0
Smith-Waterman score: 8135; 100.0% identity (100.0% similar) in 1230 aa overlap (1-1230:2461-3690)

                                             10        20        30
pF1KB3                               MPSSLMLEVPALADFNRAWTELTDWLSLLD
                                     ::::::::::::::::::::::::::::::
XP_006 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
             2440      2450      2460      2470      2480      2490

               40        50        60        70        80        90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
             2500      2510      2520      2530      2540      2550

              100       110       120       130       140       150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
             2560      2570      2580      2590      2600      2610

              160       170       180       190       200       210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
             2620      2630      2640      2650      2660      2670

              220       230       240       250       260       270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
             2680      2690      2700      2710      2720      2730

              280       290       300       310       320       330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
             2740      2750      2760      2770      2780      2790

              340       350       360       370       380       390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
             2800      2810      2820      2830      2840      2850

              400       410       420       430       440       450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
             2860      2870      2880      2890      2900      2910

              460       470       480       490       500       510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
             2920      2930      2940      2950      2960      2970

              520       530       540       550       560       570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
             2980      2990      3000      3010      3020      3030

              580       590       600       610       620       630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
             3040      3050      3060      3070      3080      3090

              640       650       660       670       680       690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
             3100      3110      3120      3130      3140      3150

              700       710       720       730       740       750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
             3160      3170      3180      3190      3200      3210

              760       770       780       790       800       810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
             3220      3230      3240      3250      3260      3270

              820       830       840       850       860       870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
             3280      3290      3300      3310      3320      3330

              880       890       900       910       920       930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
             3340      3350      3360      3370      3380      3390

              940       950       960       970       980       990
pF1KB3 RMGYLPVQTVLEGDNMETPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RMGYLPVQTVLEGDNMETPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNE
             3400      3410      3420      3430      3440      3450

             1000      1010      1020      1030      1040      1050
pF1KB3 SIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAE
             3460      3470      3480      3490      3500      3510

             1060      1070      1080      1090      1100      1110
pF1KB3 YDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHN
             3520      3530      3540      3550      3560      3570

             1120      1130      1140      1150      1160      1170
pF1KB3 KQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEE
             3580      3590      3600      3610      3620      3630

             1180      1190      1200      1210      1220      1230
pF1KB3 DLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE
             3640      3650      3660      3670      3680      3690

>--
 initn: 257 init1: 158 opt: 313  Z-score: 198.5  bits: 50.4 E(85289): 0.00026
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:1985-2426)

                                             10         20         
pF1KB3                               MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
                                     :  .. ::.  . . .    :.... :  .
XP_006 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
         1960      1970      1980      1990      2000      2010    

      30        40        50        60        70        80         
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
       .:....  . . :.::. ..  . :   ..:.:   ... .: . ..   ....   :. 
XP_006 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
         2020      2030      2040      2050       2060      2070   

      90       100       110                 120       130         
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
       . . . ... ::..:..  ..:. ....           .:  .:::    :::: : ..
XP_006 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
          2080      2090      2100      2110      2120         2130

     140       150       160       170       180       190         
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
       .   :.:... :            :.:   . : :: : . :  . ..... :  :.  .
XP_006 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
              2140              2150      2160      2170      2180 

     200       210       220       230       240       250         
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
       .    ..:  :. . :..:.:.  ::: . .:..:  ::..:. :: ::.. :..  .  
XP_006 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
            2190      2200      2210      2220      2230      2240 

     260       270       280       290       300        310        
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
       ....: :  . :: :...    ::       . ..:.:..  .: :   : ..   :. .
XP_006 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
            2250      2260             2270      2280      2290    

      320       330           340       350          360           
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
       : . :..: .. .    :. .:.....  ..  :.:.    .:..::.::. .... :. 
XP_006 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
         2300      2310      2320      2330      2340      2350    

     370             380        390         400       410       420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
        :    : :       ::: :: ::.. ...  .:  ..:. . . . .. . .:   ..
XP_006 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
         2360      2370      2380      2390      2400      2410    

              430       440       450       460       470       480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
       ...: :: :   :.                                              
XP_006 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
           2420      2430      2440      2450      2460      2470  

>>XP_016884817 (OMIM: 300376,300377,302045,310200) PREDI  (3672 aa)
 initn: 8185 init1: 7942 opt: 7942  Z-score: 4832.4  bits: 907.8 E(85289):    0
Smith-Waterman score: 7942; 99.9% identity (100.0% similar) in 1201 aa overlap (1-1201:2461-3661)

                                             10        20        30
pF1KB3                               MPSSLMLEVPALADFNRAWTELTDWLSLLD
                                     ::::::::::::::::::::::::::::::
XP_016 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
             2440      2450      2460      2470      2480      2490

               40        50        60        70        80        90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
             2500      2510      2520      2530      2540      2550

              100       110       120       130       140       150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
             2560      2570      2580      2590      2600      2610

              160       170       180       190       200       210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
             2620      2630      2640      2650      2660      2670

              220       230       240       250       260       270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
             2680      2690      2700      2710      2720      2730

              280       290       300       310       320       330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
             2740      2750      2760      2770      2780      2790

              340       350       360       370       380       390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
             2800      2810      2820      2830      2840      2850

              400       410       420       430       440       450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
             2860      2870      2880      2890      2900      2910

              460       470       480       490       500       510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
             2920      2930      2940      2950      2960      2970

              520       530       540       550       560       570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
             2980      2990      3000      3010      3020      3030

              580       590       600       610       620       630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
             3040      3050      3060      3070      3080      3090

              640       650       660       670       680       690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
             3100      3110      3120      3130      3140      3150

              700       710       720       730       740       750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
             3160      3170      3180      3190      3200      3210

              760       770       780       790       800       810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
             3220      3230      3240      3250      3260      3270

              820       830       840       850       860       870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
             3280      3290      3300      3310      3320      3330

              880       890       900       910       920       930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
             3340      3350      3360      3370      3380      3390

              940       950       960       970       980       990
pF1KB3 RMGYLPVQTVLEGDNMETPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RMGYLPVQTVLEGDNMETPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNE
             3400      3410      3420      3430      3440      3450

             1000      1010      1020      1030      1040      1050
pF1KB3 SIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAE
             3460      3470      3480      3490      3500      3510

             1060      1070      1080      1090      1100      1110
pF1KB3 YDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHN
             3520      3530      3540      3550      3560      3570

             1120      1130      1140      1150      1160      1170
pF1KB3 KQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEE
             3580      3590      3600      3610      3620      3630

             1180      1190      1200      1210      1220      1230
pF1KB3 DLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE
       :::::::::::::::::::::::::::::.:                             
XP_016 DLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM                  
             3640      3650      3660      3670                    

>--
 initn: 257 init1: 158 opt: 313  Z-score: 198.5  bits: 50.4 E(85289): 0.00026
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:1985-2426)

                                             10         20         
pF1KB3                               MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
                                     :  .. ::.  . . .    :.... :  .
XP_016 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
         1960      1970      1980      1990      2000      2010    

      30        40        50        60        70        80         
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
       .:....  . . :.::. ..  . :   ..:.:   ... .: . ..   ....   :. 
XP_016 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
         2020      2030      2040      2050       2060      2070   

      90       100       110                 120       130         
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
       . . . ... ::..:..  ..:. ....           .:  .:::    :::: : ..
XP_016 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
          2080      2090      2100      2110      2120         2130

     140       150       160       170       180       190         
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
       .   :.:... :            :.:   . : :: : . :  . ..... :  :.  .
XP_016 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
              2140              2150      2160      2170      2180 

     200       210       220       230       240       250         
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
       .    ..:  :. . :..:.:.  ::: . .:..:  ::..:. :: ::.. :..  .  
XP_016 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
            2190      2200      2210      2220      2230      2240 

     260       270       280       290       300        310        
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
       ....: :  . :: :...    ::       . ..:.:..  .: :   : ..   :. .
XP_016 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
            2250      2260             2270      2280      2290    

      320       330           340       350          360           
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
       : . :..: .. .    :. .:.....  ..  :.:.    .:..::.::. .... :. 
XP_016 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
         2300      2310      2320      2330      2340      2350    

     370             380        390         400       410       420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
        :    : :       ::: :: ::.. ...  .:  ..:. . . . .. . .:   ..
XP_016 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
         2360      2370      2380      2390      2400      2410    

              430       440       450       460       470       480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
       ...: :: :   :.                                              
XP_016 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
           2420      2430      2440      2450      2460      2470  

>>XP_016884820 (OMIM: 300376,300377,302045,310200) PREDI  (1761 aa)
 initn: 6356 init1: 6309 opt: 6332  Z-score: 3859.1  bits: 726.7 E(85289): 3.2e-208
Smith-Waterman score: 8099; 99.0% identity (99.0% similar) in 1243 aa overlap (1-1230:519-1761)

                                             10        20        30
pF1KB3                               MPSSLMLEVPALADFNRAWTELTDWLSLLD
                                     ::::::::::::::::::::::::::::::
XP_016 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
      490       500       510       520       530       540        

               40        50        60        70        80        90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
      550       560       570       580       590       600        

              100       110       120       130       140       150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
      610       620       630       640       650       660        

              160       170       180       190       200       210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
      670       680       690       700       710       720        

              220       230       240       250       260       270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
      730       740       750       760       770       780        

              280       290       300       310       320       330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
      790       800       810       820       830       840        

              340       350       360       370       380       390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
      850       860       870       880       890       900        

              400       410       420       430       440       450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
      910       920       930       940       950       960        

              460       470       480       490       500       510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
      970       980       990      1000      1010      1020        

              520       530       540       550       560       570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
     1030      1040      1050      1060      1070      1080        

              580       590       600       610       620       630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
     1090      1100      1110      1120      1130      1140        

              640       650       660       670       680       690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
     1150      1160      1170      1180      1190      1200        

              700       710       720       730       740       750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
     1210      1220      1230      1240      1250      1260        

              760       770       780       790       800       810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
     1270      1280      1290      1300      1310      1320        

              820       830       840       850       860       870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
     1330      1340      1350      1360      1370      1380        

              880       890       900       910       920       930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
     1390      1400      1410      1420      1430      1440        

              940                    950       960       970       
pF1KB3 RMGYLPVQTVLEGDNMETP-------------ASSPQLSHDDTHSRIEHYASRLAEMENS
       :::::::::::::::::::             ::::::::::::::::::::::::::::
XP_016 RMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENS
     1450      1460      1470      1480      1490      1500        

       980       990      1000      1010      1020      1030       
pF1KB3 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
     1510      1520      1530      1540      1550      1560        

      1040      1050      1060      1070      1080      1090       
pF1KB3 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
     1570      1580      1590      1600      1610      1620        

      1100      1110      1120      1130      1140      1150       
pF1KB3 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
     1630      1640      1650      1660      1670      1680        

      1160      1170      1180      1190      1200      1210       
pF1KB3 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
     1690      1700      1710      1720      1730      1740        

      1220      1230
pF1KB3 SLVSVMTDEEGAE
       :::::::::::::
XP_016 SLVSVMTDEEGAE
     1750      1760 

>--
 initn: 234 init1: 158 opt: 313  Z-score: 203.1  bits: 50.2 E(85289): 0.00014
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:43-484)

                                             10         20         
pF1KB3                               MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
                                     :  .. ::.  . . .    :.... :  .
XP_016 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
             20        30        40        50        60        70  

      30        40        50        60        70        80         
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
       .:....  . . :.::. ..  . :   ..:.:   ... .: . ..   ....   :. 
XP_016 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
             80        90       100       110        120       130 

      90       100       110                 120       130         
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
       . . . ... ::..:..  ..:. ....           .:  .:::    :::: : ..
XP_016 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
             140       150       160       170          180        

     140       150       160       170       180       190         
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
       .   :.:... :            :.:   . : :: : . :  . ..... :  :.  .
XP_016 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
      190        200               210       220       230         

     200       210       220       230       240       250         
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
       .    ..:  :. . :..:.:.  ::: . .:..:  ::..:. :: ::.. :..  .  
XP_016 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
     240       250       260       270       280       290         

     260       270       280       290       300        310        
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
       ....: :  . :: :...    ::       . ..:.:..  .: :   : ..   :. .
XP_016 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
     300       310       320              330       340       350  

      320       330           340       350          360           
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
       : . :..: .. .    :. .:.....  ..  :.:.    .:..::.::. .... :. 
XP_016 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
            360       370       380       390       400       410  

     370             380        390         400       410       420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
        :    : :       ::: :: ::.. ...  .:  ..:. . . . .. . .:   ..
XP_016 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
            420       430       440       450       460         470

              430       440       450       460       470       480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
       ...: :: :   :.                                              
XP_016 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
              480       490       500       510       520       530

>>NP_004004 (OMIM: 300376,300377,302045,310200) dystroph  (1225 aa)
 initn: 7981 init1: 6303 opt: 6326  Z-score: 3857.8  bits: 725.9 E(85289): 3.9e-208
Smith-Waterman score: 7900; 98.8% identity (98.9% similar) in 1214 aa overlap (1-1201:1-1214)

               10        20        30        40        50        60
pF1KB3 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
NP_004 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
              850       860       870       880       890       900

              910       920       930       940                    
pF1KB3 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETP-----------
       :::::::::::::::::::::::::::::::::::::::::::::::::           
NP_004 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS
              910       920       930       940       950       960

       950       960       970       980       990      1000       
pF1KB3 --ASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
              970       980       990      1000      1010      1020

      1010      1020      1030      1040      1050      1060       
pF1KB3 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
             1030      1040      1050      1060      1070      1080

      1070      1080      1090      1100      1110      1120       
pF1KB3 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
             1090      1100      1110      1120      1130      1140

      1130      1140      1150      1160      1170      1180       
pF1KB3 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
             1150      1160      1170      1180      1190      1200

      1190      1200      1210      1220      1230
pF1KB3 EQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE
       ::::::::::::.:                             
NP_004 EQLNNSFPSSRGRNTPGKPMREDTM                  
             1210      1220                       

>>NP_004012 (OMIM: 300376,300377,302045,310200) dystroph  (1243 aa)
 initn: 6350 init1: 6303 opt: 6326  Z-score: 3857.7  bits: 725.9 E(85289): 3.9e-208
Smith-Waterman score: 8093; 98.9% identity (99.0% similar) in 1243 aa overlap (1-1230:1-1243)

               10        20        30        40        50        60
pF1KB3 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
NP_004 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
              850       860       870       880       890       900

              910       920       930       940                    
pF1KB3 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETP-----------
       :::::::::::::::::::::::::::::::::::::::::::::::::           
NP_004 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS
              910       920       930       940       950       960

       950       960       970       980       990      1000       
pF1KB3 --ASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
              970       980       990      1000      1010      1020

      1010      1020      1030      1040      1050      1060       
pF1KB3 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
             1030      1040      1050      1060      1070      1080

      1070      1080      1090      1100      1110      1120       
pF1KB3 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
             1090      1100      1110      1120      1130      1140

      1130      1140      1150      1160      1170      1180       
pF1KB3 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
             1150      1160      1170      1180      1190      1200

      1190      1200      1210      1220      1230
pF1KB3 EQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE
       :::::::::::::::::::::::::::::::::::::::::::
NP_004 EQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE
             1210      1220      1230      1240   

>>XP_006724536 (OMIM: 300376,300377,302045,310200) PREDI  (3657 aa)
 initn: 6309 init1: 6309 opt: 6332  Z-score: 3854.5  bits: 726.9 E(85289): 5.8e-208
Smith-Waterman score: 8099; 99.0% identity (99.0% similar) in 1243 aa overlap (1-1230:2415-3657)

                                             10        20        30
pF1KB3                               MPSSLMLEVPALADFNRAWTELTDWLSLLD
                                     ::::::::::::::::::::::::::::::
XP_006 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
         2390      2400      2410      2420      2430      2440    

               40        50        60        70        80        90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
         2450      2460      2470      2480      2490      2500    

              100       110       120       130       140       150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
         2510      2520      2530      2540      2550      2560    

              160       170       180       190       200       210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
         2570      2580      2590      2600      2610      2620    

              220       230       240       250       260       270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
         2630      2640      2650      2660      2670      2680    

              280       290       300       310       320       330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
         2690      2700      2710      2720      2730      2740    

              340       350       360       370       380       390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
         2750      2760      2770      2780      2790      2800    

              400       410       420       430       440       450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
         2810      2820      2830      2840      2850      2860    

              460       470       480       490       500       510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
         2870      2880      2890      2900      2910      2920    

              520       530       540       550       560       570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
         2930      2940      2950      2960      2970      2980    

              580       590       600       610       620       630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
         2990      3000      3010      3020      3030      3040    

              640       650       660       670       680       690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
         3050      3060      3070      3080      3090      3100    

              700       710       720       730       740       750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
         3110      3120      3130      3140      3150      3160    

              760       770       780       790       800       810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
         3170      3180      3190      3200      3210      3220    

              820       830       840       850       860       870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
         3230      3240      3250      3260      3270      3280    

              880       890       900       910       920       930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
         3290      3300      3310      3320      3330      3340    

              940                    950       960       970       
pF1KB3 RMGYLPVQTVLEGDNMETP-------------ASSPQLSHDDTHSRIEHYASRLAEMENS
       :::::::::::::::::::             ::::::::::::::::::::::::::::
XP_006 RMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENS
         3350      3360      3370      3380      3390      3400    

       980       990      1000      1010      1020      1030       
pF1KB3 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
         3410      3420      3430      3440      3450      3460    

      1040      1050      1060      1070      1080      1090       
pF1KB3 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
         3470      3480      3490      3500      3510      3520    

      1100      1110      1120      1130      1140      1150       
pF1KB3 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
         3530      3540      3550      3560      3570      3580    

      1160      1170      1180      1190      1200      1210       
pF1KB3 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
         3590      3600      3610      3620      3630      3640    

      1220      1230
pF1KB3 SLVSVMTDEEGAE
       :::::::::::::
XP_006 SLVSVMTDEEGAE
         3650       

>--
 initn: 257 init1: 158 opt: 313  Z-score: 198.5  bits: 50.4 E(85289): 0.00025
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:1939-2380)

                                             10         20         
pF1KB3                               MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
                                     :  .. ::.  . . .    :.... :  .
XP_006 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
     1910      1920      1930      1940      1950      1960        

      30        40        50        60        70        80         
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
       .:....  . . :.::. ..  . :   ..:.:   ... .: . ..   ....   :. 
XP_006 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
     1970      1980      1990      2000       2010      2020       

      90       100       110                 120       130         
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
       . . . ... ::..:..  ..:. ....           .:  .:::    :::: : ..
XP_006 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
      2030      2040      2050      2060      2070         2080    

     140       150       160       170       180       190         
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
       .   :.:... :            :.:   . : :: : . :  . ..... :  :.  .
XP_006 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
          2090              2100      2110      2120      2130     

     200       210       220       230       240       250         
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
       .    ..:  :. . :..:.:.  ::: . .:..:  ::..:. :: ::.. :..  .  
XP_006 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
        2140      2150      2160      2170      2180      2190     

     260       270       280       290       300        310        
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
       ....: :  . :: :...    ::       . ..:.:..  .: :   : ..   :. .
XP_006 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
        2200      2210             2220      2230      2240        

      320       330           340       350          360           
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
       : . :..: .. .    :. .:.....  ..  :.:.    .:..::.::. .... :. 
XP_006 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
     2250      2260      2270      2280      2290      2300        

     370             380        390         400       410       420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
        :    : :       ::: :: ::.. ...  .:  ..:. . . . .. . .:   ..
XP_006 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
     2310      2320      2330      2340      2350      2360        

              430       440       450       460       470       480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
       ...: :: :   :.                                              
XP_006 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
       2370      2380      2390      2400      2410      2420      

>>XP_011543769 (OMIM: 300376,300377,302045,310200) PREDI  (3662 aa)
 initn: 6309 init1: 6309 opt: 6332  Z-score: 3854.5  bits: 726.9 E(85289): 5.8e-208
Smith-Waterman score: 8099; 99.0% identity (99.0% similar) in 1243 aa overlap (1-1230:2420-3662)

                                             10        20        30
pF1KB3                               MPSSLMLEVPALADFNRAWTELTDWLSLLD
                                     ::::::::::::::::::::::::::::::
XP_011 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
    2390      2400      2410      2420      2430      2440         

               40        50        60        70        80        90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
    2450      2460      2470      2480      2490      2500         

              100       110       120       130       140       150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
    2510      2520      2530      2540      2550      2560         

              160       170       180       190       200       210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
    2570      2580      2590      2600      2610      2620         

              220       230       240       250       260       270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
    2630      2640      2650      2660      2670      2680         

              280       290       300       310       320       330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
    2690      2700      2710      2720      2730      2740         

              340       350       360       370       380       390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
    2750      2760      2770      2780      2790      2800         

              400       410       420       430       440       450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
    2810      2820      2830      2840      2850      2860         

              460       470       480       490       500       510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
    2870      2880      2890      2900      2910      2920         

              520       530       540       550       560       570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
    2930      2940      2950      2960      2970      2980         

              580       590       600       610       620       630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
    2990      3000      3010      3020      3030      3040         

              640       650       660       670       680       690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
    3050      3060      3070      3080      3090      3100         

              700       710       720       730       740       750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
    3110      3120      3130      3140      3150      3160         

              760       770       780       790       800       810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
    3170      3180      3190      3200      3210      3220         

              820       830       840       850       860       870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
    3230      3240      3250      3260      3270      3280         

              880       890       900       910       920       930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
    3290      3300      3310      3320      3330      3340         

              940                    950       960       970       
pF1KB3 RMGYLPVQTVLEGDNMETP-------------ASSPQLSHDDTHSRIEHYASRLAEMENS
       :::::::::::::::::::             ::::::::::::::::::::::::::::
XP_011 RMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENS
    3350      3360      3370      3380      3390      3400         

       980       990      1000      1010      1020      1030       
pF1KB3 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
    3410      3420      3430      3440      3450      3460         

      1040      1050      1060      1070      1080      1090       
pF1KB3 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
    3470      3480      3490      3500      3510      3520         

      1100      1110      1120      1130      1140      1150       
pF1KB3 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
    3530      3540      3550      3560      3570      3580         

      1160      1170      1180      1190      1200      1210       
pF1KB3 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
    3590      3600      3610      3620      3630      3640         

      1220      1230
pF1KB3 SLVSVMTDEEGAE
       :::::::::::::
XP_011 SLVSVMTDEEGAE
    3650      3660  

>--
 initn: 257 init1: 158 opt: 313  Z-score: 198.5  bits: 50.4 E(85289): 0.00026
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:1944-2385)

                                             10         20         
pF1KB3                               MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
                                     :  .. ::.  . . .    :.... :  .
XP_011 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
          1920      1930      1940      1950      1960      1970   

      30        40        50        60        70        80         
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
       .:....  . . :.::. ..  . :   ..:.:   ... .: . ..   ....   :. 
XP_011 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
          1980      1990      2000      2010       2020      2030  

      90       100       110                 120       130         
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
       . . . ... ::..:..  ..:. ....           .:  .:::    :::: : ..
XP_011 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
           2040      2050      2060      2070      2080            

     140       150       160       170       180       190         
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
       .   :.:... :            :.:   . : :: : . :  . ..... :  :.  .
XP_011 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
    2090       2100              2110      2120      2130      2140

     200       210       220       230       240       250         
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
       .    ..:  :. . :..:.:.  ::: . .:..:  ::..:. :: ::.. :..  .  
XP_011 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
             2150      2160      2170      2180      2190      2200

     260       270       280       290       300        310        
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
       ....: :  . :: :...    ::       . ..:.:..  .: :   : ..   :. .
XP_011 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
             2210      2220             2230      2240      2250   

      320       330           340       350          360           
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
       : . :..: .. .    :. .:.....  ..  :.:.    .:..::.::. .... :. 
XP_011 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
          2260      2270      2280      2290      2300      2310   

     370             380        390         400       410       420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
        :    : :       ::: :: ::.. ...  .:  ..:. . . . .. . .:   ..
XP_011 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
          2320      2330      2340      2350      2360        2370 

              430       440       450       460       470       480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
       ...: :: :   :.                                              
XP_011 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
            2380      2390      2400      2410      2420      2430 

>>XP_006724532 (OMIM: 300376,300377,302045,310200) PREDI  (3695 aa)
 initn: 6309 init1: 6309 opt: 6332  Z-score: 3854.5  bits: 726.9 E(85289): 5.9e-208
Smith-Waterman score: 8099; 99.0% identity (99.0% similar) in 1243 aa overlap (1-1230:2453-3695)

                                             10        20        30
pF1KB3                               MPSSLMLEVPALADFNRAWTELTDWLSLLD
                                     ::::::::::::::::::::::::::::::
XP_006 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
           2430      2440      2450      2460      2470      2480  

               40        50        60        70        80        90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
           2490      2500      2510      2520      2530      2540  

              100       110       120       130       140       150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
           2550      2560      2570      2580      2590      2600  

              160       170       180       190       200       210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
           2610      2620      2630      2640      2650      2660  

              220       230       240       250       260       270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
           2670      2680      2690      2700      2710      2720  

              280       290       300       310       320       330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
           2730      2740      2750      2760      2770      2780  

              340       350       360       370       380       390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
           2790      2800      2810      2820      2830      2840  

              400       410       420       430       440       450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
           2850      2860      2870      2880      2890      2900  

              460       470       480       490       500       510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
           2910      2920      2930      2940      2950      2960  

              520       530       540       550       560       570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
           2970      2980      2990      3000      3010      3020  

              580       590       600       610       620       630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
           3030      3040      3050      3060      3070      3080  

              640       650       660       670       680       690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
           3090      3100      3110      3120      3130      3140  

              700       710       720       730       740       750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
           3150      3160      3170      3180      3190      3200  

              760       770       780       790       800       810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
           3210      3220      3230      3240      3250      3260  

              820       830       840       850       860       870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
           3270      3280      3290      3300      3310      3320  

              880       890       900       910       920       930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
           3330      3340      3350      3360      3370      3380  

              940                    950       960       970       
pF1KB3 RMGYLPVQTVLEGDNMETP-------------ASSPQLSHDDTHSRIEHYASRLAEMENS
       :::::::::::::::::::             ::::::::::::::::::::::::::::
XP_006 RMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENS
           3390      3400      3410      3420      3430      3440  

       980       990      1000      1010      1020      1030       
pF1KB3 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
           3450      3460      3470      3480      3490      3500  

      1040      1050      1060      1070      1080      1090       
pF1KB3 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
           3510      3520      3530      3540      3550      3560  

      1100      1110      1120      1130      1140      1150       
pF1KB3 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
           3570      3580      3590      3600      3610      3620  

      1160      1170      1180      1190      1200      1210       
pF1KB3 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
           3630      3640      3650      3660      3670      3680  

      1220      1230
pF1KB3 SLVSVMTDEEGAE
       :::::::::::::
XP_006 SLVSVMTDEEGAE
           3690     

>--
 initn: 257 init1: 158 opt: 313  Z-score: 198.5  bits: 50.4 E(85289): 0.00026
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:1977-2418)

                                             10         20         
pF1KB3                               MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
                                     :  .. ::.  . . .    :.... :  .
XP_006 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
       1950      1960      1970      1980      1990      2000      

      30        40        50        60        70        80         
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
       .:....  . . :.::. ..  . :   ..:.:   ... .: . ..   ....   :. 
XP_006 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
       2010      2020      2030      2040       2050      2060     

      90       100       110                 120       130         
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
       . . . ... ::..:..  ..:. ....           .:  .:::    :::: : ..
XP_006 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
        2070      2080      2090      2100      2110         2120  

     140       150       160       170       180       190         
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
       .   :.:... :            :.:   . : :: : . :  . ..... :  :.  .
XP_006 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
            2130              2140      2150      2160      2170   

     200       210       220       230       240       250         
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
       .    ..:  :. . :..:.:.  ::: . .:..:  ::..:. :: ::.. :..  .  
XP_006 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
          2180      2190      2200      2210      2220      2230   

     260       270       280       290       300        310        
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
       ....: :  . :: :...    ::       . ..:.:..  .: :   : ..   :. .
XP_006 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
          2240      2250             2260      2270      2280      

      320       330           340       350          360           
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
       : . :..: .. .    :. .:.....  ..  :.:.    .:..::.::. .... :. 
XP_006 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
       2290      2300      2310      2320      2330      2340      

     370             380        390         400       410       420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
        :    : :       ::: :: ::.. ...  .:  ..:. . . . .. . .:   ..
XP_006 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
       2350      2360      2370      2380      2390      2400      

              430       440       450       460       470       480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
       ...: :: :   :.                                              
XP_006 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
         2410      2420      2430      2440      2450      2460    

>>XP_006724531 (OMIM: 300376,300377,302045,310200) PREDI  (3703 aa)
 initn: 6309 init1: 6309 opt: 6332  Z-score: 3854.5  bits: 726.9 E(85289): 5.9e-208
Smith-Waterman score: 8099; 99.0% identity (99.0% similar) in 1243 aa overlap (1-1230:2461-3703)

                                             10        20        30
pF1KB3                               MPSSLMLEVPALADFNRAWTELTDWLSLLD
                                     ::::::::::::::::::::::::::::::
XP_006 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
             2440      2450      2460      2470      2480      2490

               40        50        60        70        80        90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
             2500      2510      2520      2530      2540      2550

              100       110       120       130       140       150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
             2560      2570      2580      2590      2600      2610

              160       170       180       190       200       210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
             2620      2630      2640      2650      2660      2670

              220       230       240       250       260       270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
             2680      2690      2700      2710      2720      2730

              280       290       300       310       320       330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
             2740      2750      2760      2770      2780      2790

              340       350       360       370       380       390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
             2800      2810      2820      2830      2840      2850

              400       410       420       430       440       450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
             2860      2870      2880      2890      2900      2910

              460       470       480       490       500       510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
             2920      2930      2940      2950      2960      2970

              520       530       540       550       560       570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
             2980      2990      3000      3010      3020      3030

              580       590       600       610       620       630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
             3040      3050      3060      3070      3080      3090

              640       650       660       670       680       690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
             3100      3110      3120      3130      3140      3150

              700       710       720       730       740       750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
             3160      3170      3180      3190      3200      3210

              760       770       780       790       800       810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
             3220      3230      3240      3250      3260      3270

              820       830       840       850       860       870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
             3280      3290      3300      3310      3320      3330

              880       890       900       910       920       930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
             3340      3350      3360      3370      3380      3390

              940                    950       960       970       
pF1KB3 RMGYLPVQTVLEGDNMETP-------------ASSPQLSHDDTHSRIEHYASRLAEMENS
       :::::::::::::::::::             ::::::::::::::::::::::::::::
XP_006 RMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENS
             3400      3410      3420      3430      3440      3450

       980       990      1000      1010      1020      1030       
pF1KB3 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
             3460      3470      3480      3490      3500      3510

      1040      1050      1060      1070      1080      1090       
pF1KB3 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
             3520      3530      3540      3550      3560      3570

      1100      1110      1120      1130      1140      1150       
pF1KB3 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
             3580      3590      3600      3610      3620      3630

      1160      1170      1180      1190      1200      1210       
pF1KB3 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
             3640      3650      3660      3670      3680      3690

      1220      1230
pF1KB3 SLVSVMTDEEGAE
       :::::::::::::
XP_006 SLVSVMTDEEGAE
             3700   

>--
 initn: 257 init1: 158 opt: 313  Z-score: 198.5  bits: 50.4 E(85289): 0.00026
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:1985-2426)

                                             10         20         
pF1KB3                               MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
                                     :  .. ::.  . . .    :.... :  .
XP_006 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
         1960      1970      1980      1990      2000      2010    

      30        40        50        60        70        80         
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
       .:....  . . :.::. ..  . :   ..:.:   ... .: . ..   ....   :. 
XP_006 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
         2020      2030      2040      2050       2060      2070   

      90       100       110                 120       130         
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
       . . . ... ::..:..  ..:. ....           .:  .:::    :::: : ..
XP_006 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
          2080      2090      2100      2110      2120         2130

     140       150       160       170       180       190         
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
       .   :.:... :            :.:   . : :: : . :  . ..... :  :.  .
XP_006 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
              2140              2150      2160      2170      2180 

     200       210       220       230       240       250         
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
       .    ..:  :. . :..:.:.  ::: . .:..:  ::..:. :: ::.. :..  .  
XP_006 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
            2190      2200      2210      2220      2230      2240 

     260       270       280       290       300        310        
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
       ....: :  . :: :...    ::       . ..:.:..  .: :   : ..   :. .
XP_006 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
            2250      2260             2270      2280      2290    

      320       330           340       350          360           
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
       : . :..: .. .    :. .:.....  ..  :.:.    .:..::.::. .... :. 
XP_006 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
         2300      2310      2320      2330      2340      2350    

     370             380        390         400       410       420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
        :    : :       ::: :: ::.. ...  .:  ..:. . . . .. . .:   ..
XP_006 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
         2360      2370      2380      2390      2400      2410    

              430       440       450       460       470       480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
       ...: :: :   :.                                              
XP_006 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
           2420      2430      2440      2450      2460      2470  




1230 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 23:17:58 2016 done: Fri Nov  4 23:18:00 2016
 Total Scan time: 15.460 Total Display time:  0.670

Function used was FASTA [36.3.4 Apr, 2011]
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