Result of FASTA (omim) for pF1KE0524
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0524, 239 aa
  1>>>pF1KE0524 239 - 239 aa - 239 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.0307+/-0.000363; mu= 16.5151+/- 0.022
 mean_var=78.5869+/-16.376, 0's: 0 Z-trim(115.4): 21  B-trim: 1592 in 3/55
 Lambda= 0.144677
 statistics sampled from 25755 (25777) to 25755 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.671), E-opt: 0.2 (0.302), width:  16
 Scan time:  6.800

The best scores are:                                      opt bits E(85289)
NP_001129223 (OMIM: 610305) derlin-3 isoform 1 [Ho ( 239) 1609 345.0 6.8e-95
NP_001002862 (OMIM: 610305) derlin-3 isoform 2 [Ho ( 235) 1402 301.8 6.8e-82
XP_011528808 (OMIM: 610305) PREDICTED: derlin-3 is ( 233) 1391 299.5 3.3e-81
NP_940842 (OMIM: 610305) derlin-3 isoform 3 [Homo  ( 205) 1386 298.4 6.2e-81
XP_011528807 (OMIM: 610305) PREDICTED: derlin-3 is ( 234) 1383 297.8 1.1e-80
XP_016884570 (OMIM: 610305) PREDICTED: derlin-3 is ( 249) 1176 254.6 1.1e-67
NP_057125 (OMIM: 610304) derlin-2 isoform a [Homo  ( 239) 1158 250.9 1.5e-66
NP_001291706 (OMIM: 610304) derlin-2 isoform b [Ho ( 238) 1139 246.9 2.3e-65
XP_016884571 (OMIM: 610305) PREDICTED: derlin-3 is ( 165) 1108 240.3 1.6e-63
XP_016884567 (OMIM: 610305) PREDICTED: derlin-3 is ( 299)  742 164.1 2.4e-40
XP_016884568 (OMIM: 610305) PREDICTED: derlin-3 is ( 298)  723 160.2 3.7e-39
NP_077271 (OMIM: 608813) derlin-1 isoform a [Homo  ( 251)  493 112.1 9.3e-25
NP_001128143 (OMIM: 608813) derlin-1 isoform b [Ho ( 231)  415 95.8   7e-20
XP_016884569 (OMIM: 610305) PREDICTED: derlin-3 is ( 279)  409 94.6 1.9e-19
NP_001291708 (OMIM: 610304) derlin-2 isoform c [Ho (  74)  280 67.1 9.2e-12
NP_001317530 (OMIM: 608813) derlin-1 isoform c [Ho ( 151)  256 62.4   5e-10
XP_006716720 (OMIM: 608813) PREDICTED: derlin-1 is ( 151)  256 62.4   5e-10


>>NP_001129223 (OMIM: 610305) derlin-3 isoform 1 [Homo s  (239 aa)
 initn: 1609 init1: 1609 opt: 1609  Z-score: 1824.6  bits: 345.0 E(85289): 6.8e-95
Smith-Waterman score: 1609; 100.0% identity (100.0% similar) in 239 aa overlap (1-239:1-239)

               10        20        30        40        50        60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
              130       140       150       160       170       180

              190       200       210       220       230         
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
              190       200       210       220       230         

>>NP_001002862 (OMIM: 610305) derlin-3 isoform 2 [Homo s  (235 aa)
 initn: 1453 init1: 1389 opt: 1402  Z-score: 1591.2  bits: 301.8 E(85289): 6.8e-82
Smith-Waterman score: 1402; 92.6% identity (94.3% similar) in 229 aa overlap (1-229:1-228)

               10        20        30        40        50        60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
              130       140       150       160       170       180

              190       200       210       220       230         
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
       ::::::::::::::::::::::::: :  . ::: .   .   . : ::          
NP_001 IYYFLEDVFPNQPGGKRLLQTPGFLKLLLD-APAEDPNYLPLPEEQPGPHLPPPQQ   
              190       200       210        220       230        

>>XP_011528808 (OMIM: 610305) PREDICTED: derlin-3 isofor  (233 aa)
 initn: 1386 init1: 1386 opt: 1391  Z-score: 1578.9  bits: 299.5 E(85289): 3.3e-81
Smith-Waterman score: 1391; 96.7% identity (98.1% similar) in 213 aa overlap (1-213:1-213)

               10        20        30        40        50        60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
              130       140       150       160       170       180

              190       200       210       220       230         
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
       :::::::::::::::::::::::::   ... :                          
XP_011 IYYFLEDVFPNQPGGKRLLQTPGFLLATAQQCPHRTGPSAGDFRAARPQLAVA      
              190       200       210       220       230         

>>NP_940842 (OMIM: 610305) derlin-3 isoform 3 [Homo sapi  (205 aa)
 initn: 1386 init1: 1386 opt: 1386  Z-score: 1574.0  bits: 298.4 E(85289): 6.2e-81
Smith-Waterman score: 1386; 100.0% identity (100.0% similar) in 205 aa overlap (1-205:1-205)

               10        20        30        40        50        60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
              130       140       150       160       170       180

              190       200       210       220       230         
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
       :::::::::::::::::::::::::                                  
NP_940 IYYFLEDVFPNQPGGKRLLQTPGFL                                  
              190       200                                       

>>XP_011528807 (OMIM: 610305) PREDICTED: derlin-3 isofor  (234 aa)
 initn: 1432 init1: 1186 opt: 1383  Z-score: 1569.8  bits: 297.8 E(85289): 1.1e-80
Smith-Waterman score: 1383; 92.1% identity (93.9% similar) in 229 aa overlap (1-229:1-227)

               10        20        30        40        50        60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
       ::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_011 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAV-LELLSPFQLYFNPHLVFRKFQVWRLVTN
               10        20        30         40        50         

               70        80        90       100       110       120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
      60        70        80        90       100       110         

              130       140       150       160       170       180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
     120       130       140       150       160       170         

              190       200       210       220       230         
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
       ::::::::::::::::::::::::: :  . ::: .   .   . : ::          
XP_011 IYYFLEDVFPNQPGGKRLLQTPGFLKLLLD-APAEDPNYLPLPEEQPGPHLPPPQQ   
     180       190       200        210       220       230       

>>XP_016884570 (OMIM: 610305) PREDICTED: derlin-3 isofor  (249 aa)
 initn: 1176 init1: 1176 opt: 1176  Z-score: 1336.0  bits: 254.6 E(85289): 1.1e-67
Smith-Waterman score: 1176; 100.0% identity (100.0% similar) in 175 aa overlap (1-175:1-175)

               10        20        30        40        50        60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::     
XP_016 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGEPPGT
              130       140       150       160       170       180

              190       200       210       220       230          
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS 
                                                                   
XP_016 SSPPQAGHSPQDTLLMPWGPSPILAGVLLTPGSIPIFLPSQLLCSYSPSSQPAHIICIVR
              190       200       210       220       230       240

>>NP_057125 (OMIM: 610304) derlin-2 isoform a [Homo sapi  (239 aa)
 initn: 1158 init1: 1158 opt: 1158  Z-score: 1315.9  bits: 250.9 E(85289): 1.5e-66
Smith-Waterman score: 1158; 79.0% identity (95.1% similar) in 205 aa overlap (1-205:1-205)

               10        20        30        40        50        60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
       ::.:.:  :.::.: :.::::.:::::::::::::..::::::::.:.:..::.:::.::
NP_057 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
       ::::::.::.:.:::.:..:::::::::::::::::::::::::: ::::.::. :: ::
NP_057 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
       :::.  :::::::::.: ::.::::::.::::::::.::::::::::::.::::::::::
NP_057 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
              130       140       150       160       170       180

              190       200       210       220       230         
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
       ::.:::::::::::: :.:.::..:                                  
NP_057 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
              190       200       210       220       230         

>>NP_001291706 (OMIM: 610304) derlin-2 isoform b [Homo s  (238 aa)
 initn: 1016 init1: 1016 opt: 1139  Z-score: 1294.5  bits: 246.9 E(85289): 2.3e-65
Smith-Waterman score: 1139; 78.5% identity (94.6% similar) in 205 aa overlap (1-205:1-204)

               10        20        30        40        50        60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
       ::.:.:  :.::.: :.::::.::::::::: :::..::::::::.:.:..::.:::.::
NP_001 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAV-LELITPFQLYFNPELIFKHFQIWRLITN
               10        20        30         40        50         

               70        80        90       100       110       120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
       ::::::.::.:.:::.:..:::::::::::::::::::::::::: ::::.::. :: ::
NP_001 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
      60        70        80        90       100       110         

              130       140       150       160       170       180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
       :::.  :::::::::.: ::.::::::.::::::::.::::::::::::.::::::::::
NP_001 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
     120       130       140       150       160       170         

              190       200       210       220       230         
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
       ::.:::::::::::: :.:.::..:                                  
NP_001 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
     180       190       200       210       220       230        

>>XP_016884571 (OMIM: 610305) PREDICTED: derlin-3 isofor  (165 aa)
 initn: 1108 init1: 1108 opt: 1108  Z-score: 1261.6  bits: 240.3 E(85289): 1.6e-63
Smith-Waterman score: 1108; 100.0% identity (100.0% similar) in 165 aa overlap (75-239:1-165)

           50        60        70        80        90       100    
pF1KE0 PHLVFRKFQVWRLVTNFLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFG
                                     ::::::::::::::::::::::::::::::
XP_016                               MLFVFRYCRMLEEGSFRGRTADFVFMFLFG
                                             10        20        30

          110       120       130       140       150       160    
pF1KE0 GVLMTLLGLLGSLFFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVLMTLLGLLGSLFFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLL
               40        50        60        70        80        90

          170       180       190       200       210       220    
pF1KE0 LGNSILVDLLGIAVGHIYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGNSILVDLLGIAVGHIYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQ
              100       110       120       130       140       150

          230         
pF1KE0 SQGGPGTAGELAAPS
       :::::::::::::::
XP_016 SQGGPGTAGELAAPS
              160     

>>XP_016884567 (OMIM: 610305) PREDICTED: derlin-3 isofor  (299 aa)
 initn: 792 init1: 742 opt: 742  Z-score: 845.4  bits: 164.1 E(85289): 2.4e-40
Smith-Waterman score: 742; 99.1% identity (100.0% similar) in 110 aa overlap (1-110:1-110)

               10        20        30        40        50        60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
       :::::::::::::::::::::::::::::::::::::::::::::::::.          
XP_016 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTVSFPQALEPRA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
                                                                   
XP_016 RAPRRPACVGPGANTAMPERDTVAVSSLVCVEGPLCAQLQGSGLDLQCCMQNTKPCTKEP
              130       140       150       160       170       180




239 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 01:56:10 2016 done: Thu Nov  3 01:56:11 2016
 Total Scan time:  6.800 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
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