Result of FASTA (omim) for pF1KB5316
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5316, 450 aa
  1>>>pF1KB5316 450 - 450 aa - 450 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.0805+/-0.000469; mu= 14.9605+/- 0.030
 mean_var=97.2154+/-19.172, 0's: 0 Z-trim(110.8): 52  B-trim: 163 in 2/51
 Lambda= 0.130079
 statistics sampled from 19245 (19289) to 19245 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.583), E-opt: 0.2 (0.226), width:  16
 Scan time:  7.820

The best scores are:                                      opt bits E(85289)
NP_001137359 (OMIM: 604508) COP9 signalosome compl ( 450) 2944 563.3 4.6e-160
NP_004227 (OMIM: 604508) COP9 signalosome complex  ( 443) 2867 548.9  1e-155
NP_002806 (OMIM: 604449) 26S proteasome non-ATPase ( 422)  386 83.2 1.4e-15
NP_001257411 (OMIM: 604449) 26S proteasome non-ATP ( 422)  386 83.2 1.4e-15


>>NP_001137359 (OMIM: 604508) COP9 signalosome complex s  (450 aa)
 initn: 2944 init1: 2944 opt: 2944  Z-score: 2994.6  bits: 563.3 E(85289): 4.6e-160
Smith-Waterman score: 2944; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450)

               10        20        30        40        50        60
pF1KB5 MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLEL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 EGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYIS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 TSKQNSDFLCQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSKQNSDFLCQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 QLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 MGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 FDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 IRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDH
              370       380       390       400       410       420

              430       440       450
pF1KB5 QKRGGARYTALDKWTNQLNSLNQAVVSKLA
       ::::::::::::::::::::::::::::::
NP_001 QKRGGARYTALDKWTNQLNSLNQAVVSKLA
              430       440       450

>>NP_004227 (OMIM: 604508) COP9 signalosome complex subu  (443 aa)
 initn: 2089 init1: 2089 opt: 2867  Z-score: 2916.6  bits: 548.9 E(85289): 1e-155
Smith-Waterman score: 2867; 98.4% identity (98.4% similar) in 450 aa overlap (1-450:1-443)

               10        20        30        40        50        60
pF1KB5 MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLEL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 EGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYIS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 TSKQNSDFLCQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILR
       ::::       :::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TSKQ-------MDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILR
                     130       140       150       160       170   

              190       200       210       220       230       240
pF1KB5 QLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLI
           180       190       200       210       220       230   

              250       260       270       280       290       300
pF1KB5 MGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINP
           240       250       260       270       280       290   

              310       320       330       340       350       360
pF1KB5 FDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRN
           300       310       320       330       340       350   

              370       380       390       400       410       420
pF1KB5 IRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDH
           360       370       380       390       400       410   

              430       440       450
pF1KB5 QKRGGARYTALDKWTNQLNSLNQAVVSKLA
       ::::::::::::::::::::::::::::::
NP_004 QKRGGARYTALDKWTNQLNSLNQAVVSKLA
           420       430       440   

>>NP_002806 (OMIM: 604449) 26S proteasome non-ATPase reg  (422 aa)
 initn: 302 init1: 229 opt: 386  Z-score: 400.6  bits: 83.2 E(85289): 1.4e-15
Smith-Waterman score: 396; 26.5% identity (57.7% similar) in 388 aa overlap (49-411:4-380)

       20        30        40        50        60        70        
pF1KB5 EYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKI
                                     ::.  ::..  : .   : ..  :....: 
NP_002                            MAAAAVVEFQRAQSLLSTDREASIDILHSIVKR
                                          10        20        30   

       80        90       100       110            120       130   
pF1KB5 NFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYI-----STSKQNSDFLCQ--
       ...  :  : ..  .: .  . : .... .   ....: :.     : :: ..  : .  
NP_002 DIQ-ENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSL
             40        50        60        70        80        90  

                    140       150          160       170       180 
pF1KB5 MDLLQEF-------YETTLEALKDAKNDRLWF---KTNTKLGKLYLEREEYGKLQKILRQ
       .::. ..        :  :: .. ::...  :     ...: .::.. ..: .  ..  :
NP_002 LDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQ
            100       110       120       130       140       150  

             190       200       210       220       230           
pF1KB5 LHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAI--PHPL
       : .  .  : .      . :.:.  :: . : : .:  : .:   ..    .::  : : 
NP_002 LLRELKKMDDK------ALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCP-PK
            160             170       180       190       200      

     240       250        260       270       280       290        
pF1KB5 IMGVIRECGGKMHL-REGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGI
       .....   .: .:  .: ... :.. :.:::..::   ::.  : :::..: ......  
NP_002 LQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNT--
         210       220       230       240       250       260     

      300       310            320       330       340       350   
pF1KB5 NPFDSQEAKPYK-----NDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREH
        : : :     :        .  :.  ...: .: ....::: :   .... :::.:  :
NP_002 -PEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTH
            270       280       290       300       310       320  

           360       370       380       390       400       410   
pF1KB5 IEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVN
       . .:  :.  : ::..:.:..:..:  ::. .... ::::  : : :::. .:: .::  
NP_002 LAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGE
            330       340       350       360       370       380  

           420       430       440       450   
pF1KB5 QLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA   
                                               
NP_002 GVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT
            390       400       410       420  

>>NP_001257411 (OMIM: 604449) 26S proteasome non-ATPase   (422 aa)
 initn: 302 init1: 229 opt: 386  Z-score: 400.6  bits: 83.2 E(85289): 1.4e-15
Smith-Waterman score: 396; 26.5% identity (57.7% similar) in 388 aa overlap (49-411:4-380)

       20        30        40        50        60        70        
pF1KB5 EYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKI
                                     ::.  ::..  : .   : ..  :....: 
NP_001                            MAAAAVVEFQRAQSLLSTDREASIDILHSIVKR
                                          10        20        30   

       80        90       100       110            120       130   
pF1KB5 NFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYI-----STSKQNSDFLCQ--
       ...  :  : ..  .: .  . : .... .   ....: :.     : :: ..  : .  
NP_001 DIQ-ENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSL
             40        50        60        70        80        90  

                    140       150          160       170       180 
pF1KB5 MDLLQEF-------YETTLEALKDAKNDRLWF---KTNTKLGKLYLEREEYGKLQKILRQ
       .::. ..        :  :: .. ::...  :     ...: .::.. ..: .  ..  :
NP_001 LDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQ
            100       110       120       130       140       150  

             190       200       210       220       230           
pF1KB5 LHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAI--PHPL
       : .  .  : .      . :.:.  :: . : : .:  : .:   ..    .::  : : 
NP_001 LLRELKKMDDK------ALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCP-PK
            160             170       180       190       200      

     240       250        260       270       280       290        
pF1KB5 IMGVIRECGGKMHL-REGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGI
       .....   .: .:  .: ... :.. :.:::..::   ::.  : :::..: ......  
NP_001 LQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNT--
         210       220       230       240       250       260     

      300       310            320       330       340       350   
pF1KB5 NPFDSQEAKPYK-----NDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREH
        : : :     :        .  :.  ...: .: ....::: :   .... :::.:  :
NP_001 -PEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTH
            270       280       290       300       310       320  

           360       370       380       390       400       410   
pF1KB5 IEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVN
       . .:  :.  : ::..:.:..:..:  ::. .... ::::  : : :::. .:: .::  
NP_001 LAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGE
            330       340       350       360       370       380  

           420       430       440       450   
pF1KB5 QLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA   
                                               
NP_001 GVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT
            390       400       410       420  




450 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 00:57:44 2016 done: Sat Nov  5 00:57:45 2016
 Total Scan time:  7.820 Total Display time:  0.010

Function used was FASTA [36.3.4 Apr, 2011]
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