Result of FASTA (omim) for pF1KB6688
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6688, 458 aa
  1>>>pF1KB6688 458 - 458 aa - 458 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.9420+/-0.000424; mu= 19.9821+/- 0.027
 mean_var=100.2974+/-24.247, 0's: 0 Z-trim(110.9): 628  B-trim: 1891 in 2/48
 Lambda= 0.128065
 statistics sampled from 18525 (19307) to 18525 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.576), E-opt: 0.2 (0.226), width:  16
 Scan time:  7.560

The best scores are:                                      opt bits E(85289)
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 3011 567.7 2.3e-161
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 3011 567.7 2.3e-161
NP_001243690 (OMIM: 312861) 5-hydroxytryptamine re ( 248)  988 193.6 5.1e-49
NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471)  939 184.9 4.1e-46
NP_001307687 (OMIM: 601122) 5-hydroxytryptamine re ( 439)  790 157.3 7.6e-38
XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 456)  790 157.3 7.8e-38
NP_000858 (OMIM: 601122) 5-hydroxytryptamine recep ( 481)  790 157.4 8.1e-38
NP_001159419 (OMIM: 103780,164230,181500,182135,60 ( 387)  677 136.4 1.4e-31
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377)  623 126.4 1.3e-28
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572)  600 122.3 3.3e-27
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390)  574 117.3 7.3e-26
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic  ( 408)  544 111.8 3.5e-24
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328)  531 109.3 1.6e-23
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331)  531 109.3 1.6e-23
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366)  531 109.4 1.7e-23
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389)  531 109.4 1.8e-23
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402)  531 109.4 1.8e-23
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520)  532 109.7 1.9e-23
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556)  531 109.6 2.2e-23
NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365)  519 107.1   8e-23
XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365)  519 107.1   8e-23
NP_387512 (OMIM: 126451,181500,190300) D(3) dopami ( 367)  519 107.1   8e-23
XP_005246577 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 362)  508 105.1 3.3e-22
NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414)  487 101.3 5.2e-21
NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443)  487 101.3 5.4e-21
XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443)  487 101.3 5.4e-21
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446)  467 97.6 7.1e-20
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic  ( 477)  462 96.7 1.4e-19
NP_000789 (OMIM: 126453,143465,606798) D(1B) dopam ( 477)  457 95.8 2.7e-19
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308)  450 94.3 4.9e-19
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317)  450 94.3   5e-19
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324)  450 94.3 5.1e-19
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342)  450 94.4 5.3e-19
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370)  450 94.4 5.5e-19
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372)  450 94.4 5.6e-19
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429)  450 94.5 6.1e-19
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429)  450 94.5 6.1e-19
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455)  450 94.5 6.3e-19
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466)  450 94.5 6.4e-19
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475)  450 94.5 6.5e-19
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475)  450 94.5 6.5e-19
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475)  450 94.5 6.5e-19
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475)  450 94.5 6.5e-19
NP_001269492 (OMIM: 126451,181500,190300) D(3) dop ( 400)  431 90.9 6.6e-18
NP_000787 (OMIM: 126451,181500,190300) D(3) dopami ( 400)  431 90.9 6.6e-18
XP_016861318 (OMIM: 126451,181500,190300) PREDICTE ( 400)  431 90.9 6.6e-18
NP_001277738 (OMIM: 126451,181500,190300) D(3) dop ( 400)  431 90.9 6.6e-18
NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450)  419 88.8 3.3e-17
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359)  410 87.0 9.1e-17
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362)  410 87.0 9.2e-17


>>NP_000859 (OMIM: 312861) 5-hydroxytryptamine receptor   (458 aa)
 initn: 3011 init1: 3011 opt: 3011  Z-score: 3017.9  bits: 567.7 E(85289): 2.3e-161
Smith-Waterman score: 3011; 99.8% identity (99.8% similar) in 458 aa overlap (1-458:1-458)

               10        20        30        40        50        60
pF1KB6 MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
       :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
NP_000 MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
              370       380       390       400       410       420

              430       440       450        
pF1KB6 EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
       ::::::::::::::::::::::::::::::::::::::
NP_000 EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
              430       440       450        

>>NP_001243689 (OMIM: 312861) 5-hydroxytryptamine recept  (458 aa)
 initn: 3011 init1: 3011 opt: 3011  Z-score: 3017.9  bits: 567.7 E(85289): 2.3e-161
Smith-Waterman score: 3011; 99.8% identity (99.8% similar) in 458 aa overlap (1-458:1-458)

               10        20        30        40        50        60
pF1KB6 MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
       :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
NP_001 MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
              370       380       390       400       410       420

              430       440       450        
pF1KB6 EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
       ::::::::::::::::::::::::::::::::::::::
NP_001 EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
              430       440       450        

>>NP_001243690 (OMIM: 312861) 5-hydroxytryptamine recept  (248 aa)
 initn: 988 init1: 988 opt: 988  Z-score: 1001.0  bits: 193.6 E(85289): 5.1e-49
Smith-Waterman score: 988; 97.4% identity (98.7% similar) in 155 aa overlap (1-155:1-155)

               10        20        30        40        50        60
pF1KB6 MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
       :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
NP_001 MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
       :::::::::::::::::::::::::::::::: ..                         
NP_001 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRCISSYPCDWTEGRRKGVREQHDVRAQRP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
                                                                   
NP_001 KFRSYWVLRSFLHTADDYGDYVLPDHLRSAPTSFDVTARPHRGTAWTKSGFPEVLQEEYG
              190       200       210       220       230       240

>>NP_000612 (OMIM: 103780,164230,181500,182135,606788,60  (471 aa)
 initn: 1240 init1: 769 opt: 939  Z-score: 948.9  bits: 184.9 E(85289): 4.1e-46
Smith-Waterman score: 1413; 55.0% identity (78.0% similar) in 409 aa overlap (53-458:74-471)

             30        40        50        60        70        80  
pF1KB6 SDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEK
                                     .:: ::  ...::.::.::::::::::.::
NP_000 NWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEK
            50        60        70        80        90       100   

             90       100       110       120       130       140  
pF1KB6 KLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASI
       ::.::::::::::::::::.:.::::.:.:.::: : ::::  :: ::: ::::::::::
NP_000 KLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASI
           110       120       130       140       150       160   

            150       160       170       180       190       200  
pF1KB6 MHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFV
       ::::::::::::::.:::.::::::::::..::  ::.::.:.:.::::.::.:. ::: 
NP_000 MHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVF-
           170       180       190       200       210       220   

            210       220       230       240       250       260  
pF1KB6 NNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLD
       .. .:.: : :::::::::.:::::::::::: :::  :...: . .     .    :..
NP_000 KEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFS
            230       240       250       260       270       280  

            270       280       290       300       310       320  
pF1KB6 FLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLI
       ::         . . .. .  : . .:.      : :::.:.::.:: ::::::::.:..
NP_000 FLP--------QSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVV
                    290       300       310       320       330    

            330       340       350       360       370       380  
pF1KB6 MWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY
       ::::::::::..:.:..:::. ..  ::::::::::. :..:::::::::: :: ::: :
NP_000 MWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY
          340       350       360       370       380       390    

            390        400       410       420       430           
pF1KB6 LRCNYKVEKKP-PVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEM--QVE
       ..:.:: .:::  .  .  . : : .. .:...  ..... .  :..::. ..    . .
NP_000 IQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDA--KTTDNDCSMVALGKQH
          400       410       420       430         440       450  

     440       450        
pF1KB6 NLELPVNPSSVVSERISSV
       . :   . :. :.:..: :
NP_000 SEEASKDNSDGVNEKVSCV
            460       470 

>>NP_001307687 (OMIM: 601122) 5-hydroxytryptamine recept  (439 aa)
 initn: 1236 init1: 640 opt: 790  Z-score: 800.4  bits: 157.3 E(85289): 7.6e-38
Smith-Waterman score: 1208; 52.4% identity (78.5% similar) in 353 aa overlap (54-391:13-361)

            30        40        50        60        70        80   
pF1KB6 DISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKK
                                     .: :: :...:: ::::: :::.:::.:::
NP_001                   MKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK
                                 10        20        30        40  

            90       100       110       120       130       140   
pF1KB6 LHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIM
       :. ::::::::::.::.::::.:::..::.:... .::::  :::.:. :::::::::::
NP_001 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM
             50        60        70        80        90       100  

           150       160       170       180       190       200   
pF1KB6 HLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVN
       ::::::.:::.::..::. ...:::. :..::..:: ::::...:.:. :.. .     :
NP_001 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDN-PN
            110       120       130       140       150        160 

           210          220       230       240       250       260
pF1KB6 NTTCVLNDP---NFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLS
       : ::::.     .:.:.::..::: ::.::..:: :::..:...: .. .   ..   :.
NP_001 NITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLT
             170       180       190       200       210       220 

                    270            280        290       300        
pF1KB6 L------DFLKCCKRNTAE-----EENSANPNQ-DQNARRRKKKERRPRGTMQAINNERK
       .      :   : . . .      ....: ::. :..  :: .     . ..:.:.::..
NP_001 VSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTI--GKKSVQTISNEQR
             230       240       250       260         270         

      310       320       330       340       350       360        
pF1KB6 ASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVY
       ::::::::::.::.::::::::::  :::. ::::  .. ::..::::::: ::.:::::
NP_001 ASKVLGIVFFLFLLMWCPFFITNITLVLCD-SCNQTTLQMLLEIFVWIGYVSSGVNPLVY
     280       290       300        310       320       330        

      370       380       390       400       410       420        
pF1KB6 TLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKAS
       ::::: .: ::. :. :::.. :                                     
NP_001 TLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPA
      340       350       360       370       380       390        

>>XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytrypta  (456 aa)
 initn: 1236 init1: 640 opt: 790  Z-score: 800.2  bits: 157.3 E(85289): 7.8e-38
Smith-Waterman score: 1208; 52.4% identity (78.5% similar) in 353 aa overlap (54-391:30-378)

            30        40        50        60        70        80   
pF1KB6 DISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKK
                                     .: :: :...:: ::::: :::.:::.:::
XP_006  MLSKITTKPETESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK
                10        20        30        40        50         

            90       100       110       120       130       140   
pF1KB6 LHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIM
       :. ::::::::::.::.::::.:::..::.:... .::::  :::.:. :::::::::::
XP_006 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM
      60        70        80        90       100       110         

           150       160       170       180       190       200   
pF1KB6 HLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVN
       ::::::.:::.::..::. ...:::. :..::..:: ::::...:.:. :.. .     :
XP_006 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDN-PN
     120       130       140       150       160       170         

           210          220       230       240       250       260
pF1KB6 NTTCVLNDP---NFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLS
       : ::::.     .:.:.::..::: ::.::..:: :::..:...: .. .   ..   :.
XP_006 NITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLT
      180       190       200       210       220       230        

                    270            280        290       300        
pF1KB6 L------DFLKCCKRNTAE-----EENSANPNQ-DQNARRRKKKERRPRGTMQAINNERK
       .      :   : . . .      ....: ::. :..  :: .     . ..:.:.::..
XP_006 VSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTI--GKKSVQTISNEQR
      240       250       260       270       280         290      

      310       320       330       340       350       360        
pF1KB6 ASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVY
       ::::::::::.::.::::::::::  :::. ::::  .. ::..::::::: ::.:::::
XP_006 ASKVLGIVFFLFLLMWCPFFITNITLVLCD-SCNQTTLQMLLEIFVWIGYVSSGVNPLVY
        300       310       320        330       340       350     

      370       380       390       400       410       420        
pF1KB6 TLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKAS
       ::::: .: ::. :. :::.. :                                     
XP_006 TLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPA
         360       370       380       390       400       410     

>>NP_000858 (OMIM: 601122) 5-hydroxytryptamine receptor   (481 aa)
 initn: 1236 init1: 640 opt: 790  Z-score: 800.0  bits: 157.4 E(85289): 8.1e-38
Smith-Waterman score: 1208; 52.4% identity (78.5% similar) in 353 aa overlap (54-391:55-403)

            30        40        50        60        70        80   
pF1KB6 DISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKK
                                     .: :: :...:: ::::: :::.:::.:::
NP_000 HVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK
           30        40        50        60        70        80    

            90       100       110       120       130       140   
pF1KB6 LHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIM
       :. ::::::::::.::.::::.:::..::.:... .::::  :::.:. :::::::::::
NP_000 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM
           90       100       110       120       130       140    

           150       160       170       180       190       200   
pF1KB6 HLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVN
       ::::::.:::.::..::. ...:::. :..::..:: ::::...:.:. :.. .     :
NP_000 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDN-PN
          150       160       170       180       190       200    

           210          220       230       240       250       260
pF1KB6 NTTCVLNDP---NFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLS
       : ::::.     .:.:.::..::: ::.::..:: :::..:...: .. .   ..   :.
NP_000 NITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLT
           210       220       230       240       250       260   

                    270            280        290       300        
pF1KB6 L------DFLKCCKRNTAE-----EENSANPNQ-DQNARRRKKKERRPRGTMQAINNERK
       .      :   : . . .      ....: ::. :..  :: .     . ..:.:.::..
NP_000 VSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTI--GKKSVQTISNEQR
           270       280       290       300         310       320 

      310       320       330       340       350       360        
pF1KB6 ASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVY
       ::::::::::.::.::::::::::  :::. ::::  .. ::..::::::: ::.:::::
NP_000 ASKVLGIVFFLFLLMWCPFFITNITLVLCD-SCNQTTLQMLLEIFVWIGYVSSGVNPLVY
             330       340       350        360       370       380

      370       380       390       400       410       420        
pF1KB6 TLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKAS
       ::::: .: ::. :. :::.. :                                     
NP_000 TLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPA
              390       400       410       420       430       440

>>NP_001159419 (OMIM: 103780,164230,181500,182135,606788  (387 aa)
 initn: 931 init1: 485 opt: 677  Z-score: 688.2  bits: 136.4 E(85289): 1.4e-31
Smith-Waterman score: 1104; 51.5% identity (75.0% similar) in 344 aa overlap (118-458:55-387)

        90       100       110       120       130       140       
pF1KB6 TNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCA
                                     : ::::  :: ::: :::::::::::::::
NP_001 GTLHQFNYCERCSESQNNKCISCVDPEDKWYRWPLPSKLCAVWIYLDVLFSTASIMHLCA
           30        40        50        60        70        80    

       150       160       170       180       190       200       
pF1KB6 ISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTC
       :::::::::.:::.::::::::::..::  ::.::.:.:.::::.::.:. ::: .. .:
NP_001 ISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVF-KEGSC
           90       100       110       120       130        140   

       210       220       230       240       250       260       
pF1KB6 VLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCC
       .: : :::::::::.:::::::::::: :::  :...: . .     .    :..::   
NP_001 LLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLP--
           150       160       170       180       190       200   

       270       280       290       300       310       320       
pF1KB6 KRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPF
             . . .. .  : . .:.      : :::.:.::.:: ::::::::.:..:::::
NP_001 ------QSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPF
                   210       220       230       240       250     

       330       340       350       360       370       380       
pF1KB6 FITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNY
       :::::..:.:..:::. ..  ::::::::::. :..:::::::::: :: ::: :..:.:
NP_001 FITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQY
         260       270       280       290       300       310     

       390        400       410       420       430         440    
pF1KB6 KVEKKP-PVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEM--QVENLELP
       : .:::  .  .  . : : .. .:...  ..... .  :..::. ..    . .. :  
NP_001 KENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDA--KTTDNDCSMVALGKQHSEEAS
         320       330       340       350         360       370   

          450        
pF1KB6 VNPSSVVSERISSV
        . :. :.:..: :
NP_001 KDNSDGVNEKVSCV
           380       

>>NP_000855 (OMIM: 182133) 5-hydroxytryptamine receptor   (377 aa)
 initn: 562 init1: 228 opt: 623  Z-score: 634.4  bits: 126.4 E(85289): 1.3e-28
Smith-Waterman score: 623; 33.2% identity (64.7% similar) in 334 aa overlap (57-379:42-367)

         30        40        50        60        70        80      
pF1KB6 VSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHN
                                     :. . .: . :. .: .:. .. . .:::.
NP_000 PQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHT
              20        30        40        50        60        70 

         90       100       110       120       130       140      
pF1KB6 ATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLC
        .::.. ::: .:.::..::::.:. :    ..: . . :: .:.: :.   ::::.:::
NP_000 PANYLIGSLATTDLLVSILVMPISI-AYTITHTWNFGQILCDIWLSSDITCCTASILHLC
              80        90        100       110       120       130

        150       160       170       180       190       200      
pF1KB6 AISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTT
       .:.:::: :: . .:.:.  .  .:   ::::::::: .:.: :.  .  . :.  . . 
NP_000 VIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIP-PL--FWRQAKAQEEMSD
              140       150       160       170          180       

        210         220       230       240          250       260 
pF1KB6 CVLNDP--NFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALM---LLHGHTEEPPGLSL
       :..:    .... ..  ::.:: ....: :   ::   :. ..    :.:.      :  
NP_000 CLVNTSQISYTIYSTCGAFYIPSVLLIILYG-RIYRAARNRILNPPSLYGKRFTTAHLIT
       190       200       210        220       230       240      

               270           280       290       300       310     
pF1KB6 DFL--KCCKRNTAEEE----NSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGI
            . :. :.. .:    ....:   .... .       :  ..:   ::::.:.:::
NP_000 GSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAAR-ERKATKILGI
        250       260       270       280       290        300     

         320       330       340       350       360       370     
pF1KB6 VFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIY
       .. .:.: : :::.....  .:. ::   .   :.. :.:.::. : :::..::.::. .
NP_000 ILGAFIICWLPFFVVSLVLPICRDSC--WIHPALFDFFTWLGYLNSLINPIIYTVFNEEF
         310       320       330         340       350       360   

         380       390       400       410       420       430     
pF1KB6 RRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIE
       :.::                                                        
NP_000 RQAFQKIVPFRKAS                                              
           370                                                     

>>NP_000669 (OMIM: 104219) alpha-1D adrenergic receptor   (572 aa)
 initn: 490 init1: 207 opt: 600  Z-score: 609.4  bits: 122.3 E(85289): 3.3e-27
Smith-Waterman score: 603; 29.3% identity (64.0% similar) in 389 aa overlap (60-444:103-470)

      30        40        50        60        70        80         
pF1KB6 VAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATN
                                     .. .:.:...::.:::..:. ...:...::
NP_000 GSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTN
             80        90       100       110       120       130  

      90       100       110       120       130       140         
pF1KB6 YFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAIS
       ::...::.::.:..  :.:.:    .  . : . : .: :: ..:::  ::::. ::.::
NP_000 YFIVNLAVADLLLSATVLPFSATMEVLGF-WAFGRAFCDVWAAVDVLCCTASILSLCTIS
            140       150       160        170       180       190 

     150       160       170       180       190       200         
pF1KB6 LDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTC-V
       .::::..:. ...  . .. ::   .:..:.... :::  :..: .  : :  ..  : .
NP_000 VDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVG-PLLGWK--EPVPPDERFCGI
             200       210       220       230          240        

      210       220       230       240       250       260        
pF1KB6 LNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDF-LKCC
        .. ......:  .:..:....:. ::  .::. :..   :.. ...  : . .  :.  
NP_000 TEEAGYAVFSSVCSFYLPMAVIVVMYC-RVYVVARSTTRSLEAGVKRERGKASEVVLRIH
      250       260       270        280       290       300       

       270       280       290       300         310       320     
pF1KB6 KRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAI--NNERKASKVLGIVFFVFLIMWC
        :..:   ..:.     . :  : .  :   ... .  . :.::.:.:.::  ::.. : 
NP_000 CRGAATGADGAH-----GMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWF
       310            320       330       340       350       360  

         330       340       350       360       370       380     
pF1KB6 PFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC
       :::..  :. :  .    :  : ...:. :.::  : .:::.:   .. ..:::   :::
NP_000 PFFFVLPLGSLFPQ---LKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRC
            370          380       390       400       410         

         390       400       410       420       430       440     
pF1KB6 NYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPV
       . . ...   : . :: .    .   ...  :.   :   ...:  ::  . .  :  : 
NP_000 QCRRRRRR--RPLWRVYGHHWRA---STSGLRQDCAP---SSGDAPPGAPLALTALPDPD
     420         430       440          450          460       470 

         450                                                       
pF1KB6 NPSSVVSERISSV                                               
                                                                   
NP_000 PEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEA
             480       490       500       510       520       530 




458 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 18:48:08 2016 done: Sat Nov  5 18:48:09 2016
 Total Scan time:  7.560 Total Display time:  0.060

Function used was FASTA [36.3.4 Apr, 2011]
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