Result of FASTA (omim) for pF1KB7322
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7322, 2352 aa
  1>>>pF1KB7322 2352 - 2352 aa - 2352 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 16.6597+/-0.000575; mu= -26.6452+/- 0.036
 mean_var=792.5601+/-163.990, 0's: 0 Z-trim(122.3): 428  B-trim: 0 in 0/61
 Lambda= 0.045557
 statistics sampled from 39780 (40254) to 39780 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.733), E-opt: 0.2 (0.472), width:  16
 Scan time: 20.020

The best scores are:                                      opt bits E(85289)
NP_942592 (OMIM: 615929) ankyrin repeat domain-con (2352) 15375 1028.1       0
XP_005265728 (OMIM: 615929) PREDICTED: ankyrin rep (2351) 15358 1027.0       0
XP_016863501 (OMIM: 615929) PREDICTED: ankyrin rep (2239) 14514 971.5       0
XP_016863502 (OMIM: 615929) PREDICTED: ankyrin rep (2238) 14497 970.4       0
NP_001273700 (OMIM: 615929) ankyrin repeat domain- (2490) 10338 697.1 7.3e-199
NP_115593 (OMIM: 615929) ankyrin repeat domain-con (2603) 10338 697.1 7.6e-199
XP_016863500 (OMIM: 615929) PREDICTED: ankyrin rep (2489) 10333 696.7 9.2e-199
NP_056389 (OMIM: 615929) ankyrin repeat domain-con (2602) 10333 696.7 9.5e-199
XP_016863505 (OMIM: 615929) PREDICTED: ankyrin rep (1229) 7847 533.1 8.3e-150
XP_016863506 (OMIM: 615929) PREDICTED: ankyrin rep (1116) 6986 476.5 8.3e-133
XP_016863503 (OMIM: 615929) PREDICTED: ankyrin rep (1479) 5066 350.4   1e-94
XP_005265730 (OMIM: 615929) PREDICTED: ankyrin rep (1480) 5066 350.4   1e-94
XP_005265729 (OMIM: 615929) PREDICTED: ankyrin rep (1543) 5066 350.4   1e-94
XP_016863504 (OMIM: 615929) PREDICTED: ankyrin rep (1367) 4205 293.8   1e-77
NP_060217 (OMIM: 610500) ankyrin repeat and KH dom (2542) 3796 267.1   2e-69
NP_078944 (OMIM: 610500) ankyrin repeat and KH dom ( 627) 2991 213.7 5.9e-54
NP_001183959 (OMIM: 610500) ankyrin repeat and KH  ( 581) 2750 197.8 3.3e-49
NP_060448 (OMIM: 610500) ankyrin repeat and KH dom ( 616) 2600 188.0 3.2e-46
XP_016863601 (OMIM: 106410,600919) PREDICTED: anky (1689)  847 73.1 3.3e-11
XP_016863597 (OMIM: 106410,600919) PREDICTED: anky (1772)  847 73.1 3.4e-11
XP_016863600 (OMIM: 106410,600919) PREDICTED: anky (1755)  842 72.8 4.3e-11
XP_016863599 (OMIM: 106410,600919) PREDICTED: anky (1763)  842 72.8 4.3e-11
XP_016863598 (OMIM: 106410,600919) PREDICTED: anky (1770)  842 72.8 4.3e-11
XP_016863594 (OMIM: 106410,600919) PREDICTED: anky (1810)  842 72.8 4.4e-11
XP_016863592 (OMIM: 106410,600919) PREDICTED: anky (1816)  842 72.8 4.4e-11
XP_016863593 (OMIM: 106410,600919) PREDICTED: anky (1818)  842 72.8 4.4e-11
XP_016863590 (OMIM: 106410,600919) PREDICTED: anky (1839)  842 72.8 4.4e-11
XP_016863588 (OMIM: 106410,600919) PREDICTED: anky (1850)  842 72.8 4.4e-11
XP_016863587 (OMIM: 106410,600919) PREDICTED: anky (1851)  842 72.8 4.4e-11
XP_016863585 (OMIM: 106410,600919) PREDICTED: anky (1862)  842 72.8 4.5e-11
NP_001120965 (OMIM: 106410,600919) ankyrin-2 isofo (1863)  842 72.8 4.5e-11
XP_016863583 (OMIM: 106410,600919) PREDICTED: anky (1871)  842 72.8 4.5e-11
XP_016863584 (OMIM: 106410,600919) PREDICTED: anky (1871)  842 72.8 4.5e-11
NP_066187 (OMIM: 106410,600919) ankyrin-2 isoform  (1872)  842 72.8 4.5e-11
XP_016863582 (OMIM: 106410,600919) PREDICTED: anky (1881)  842 72.8 4.5e-11
XP_016863581 (OMIM: 106410,600919) PREDICTED: anky (1882)  842 72.8 4.5e-11
XP_016863579 (OMIM: 106410,600919) PREDICTED: anky (1886)  842 72.8 4.5e-11
XP_016863578 (OMIM: 106410,600919) PREDICTED: anky (1887)  842 72.8 4.5e-11
XP_016863577 (OMIM: 106410,600919) PREDICTED: anky (1893)  842 72.8 4.5e-11
XP_016863576 (OMIM: 106410,600919) PREDICTED: anky (1898)  842 72.8 4.5e-11
XP_016863575 (OMIM: 106410,600919) PREDICTED: anky (1899)  842 72.8 4.5e-11
XP_016863574 (OMIM: 106410,600919) PREDICTED: anky (1902)  842 72.8 4.5e-11
XP_016863573 (OMIM: 106410,600919) PREDICTED: anky (1915)  842 72.8 4.6e-11
XP_016863572 (OMIM: 106410,600919) PREDICTED: anky (1917)  842 72.8 4.6e-11
XP_016863571 (OMIM: 106410,600919) PREDICTED: anky (1926)  842 72.8 4.6e-11
XP_016863570 (OMIM: 106410,600919) PREDICTED: anky (1931)  842 72.8 4.6e-11
XP_016863569 (OMIM: 106410,600919) PREDICTED: anky (1970)  842 72.8 4.7e-11
XP_016863568 (OMIM: 106410,600919) PREDICTED: anky (2006)  842 72.9 4.7e-11
XP_016863567 (OMIM: 106410,600919) PREDICTED: anky (2020)  842 72.9 4.7e-11
XP_016863596 (OMIM: 106410,600919) PREDICTED: anky (1797)  839 72.6   5e-11


>>NP_942592 (OMIM: 615929) ankyrin repeat domain-contain  (2352 aa)
 initn: 15375 init1: 15375 opt: 15375  Z-score: 5480.7  bits: 1028.1 E(85289):    0
Smith-Waterman score: 15375; 100.0% identity (100.0% similar) in 2352 aa overlap (1-2352:1-2352)

               10        20        30        40        50        60
pF1KB7 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB7 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB7 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB7 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB7 GRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 GRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB7 AGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 AGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB7 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB7 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB7 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB7 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB7 AAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 AAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAE
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB7 ANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 ANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFE
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KB7 LQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 LQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKN
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KB7 RKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 RKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNS
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KB7 SRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLSTCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 SRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLSTCT
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KB7 KSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 KSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAI
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KB7 REFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 REFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKS
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KB7 SSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 SSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVN
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KB7 NVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 NVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRP
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KB7 LSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 LSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSS
             1690      1700      1710      1720      1730      1740

             1750      1760      1770      1780      1790      1800
pF1KB7 PSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 PSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ
             1750      1760      1770      1780      1790      1800

             1810      1820      1830      1840      1850      1860
pF1KB7 PGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 PGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQP
             1810      1820      1830      1840      1850      1860

             1870      1880      1890      1900      1910      1920
pF1KB7 PGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 PGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTP
             1870      1880      1890      1900      1910      1920

             1930      1940      1950      1960      1970      1980
pF1KB7 KMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSACQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 KMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSACQ
             1930      1940      1950      1960      1970      1980

             1990      2000      2010      2020      2030      2040
pF1KB7 NSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 NSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYL
             1990      2000      2010      2020      2030      2040

             2050      2060      2070      2080      2090      2100
pF1KB7 PNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 PNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQM
             2050      2060      2070      2080      2090      2100

             2110      2120      2130      2140      2150      2160
pF1KB7 YGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPLGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 YGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPLGS
             2110      2120      2130      2140      2150      2160

             2170      2180      2190      2200      2210      2220
pF1KB7 EKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 EKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDK
             2170      2180      2190      2200      2210      2220

             2230      2240      2250      2260      2270      2280
pF1KB7 VDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 VDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGM
             2230      2240      2250      2260      2270      2280

             2290      2300      2310      2320      2330      2340
pF1KB7 PFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGPWA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_942 PFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGPWA
             2290      2300      2310      2320      2330      2340

             2350  
pF1KB7 PHMNSVHMNQLG
       ::::::::::::
NP_942 PHMNSVHMNQLG
             2350  

>>XP_005265728 (OMIM: 615929) PREDICTED: ankyrin repeat   (2351 aa)
 initn: 10334 init1: 10334 opt: 15358  Z-score: 5474.7  bits: 1027.0 E(85289):    0
Smith-Waterman score: 15358; 100.0% identity (100.0% similar) in 2352 aa overlap (1-2352:1-2351)

               10        20        30        40        50        60
pF1KB7 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB7 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB7 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB7 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
XP_005 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNK-VS
              730       740       750       760       770          

              790       800       810       820       830       840
pF1KB7 GRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC
     780       790       800       810       820       830         

              850       860       870       880       890       900
pF1KB7 AGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD
     840       850       860       870       880       890         

              910       920       930       940       950       960
pF1KB7 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS
     900       910       920       930       940       950         

              970       980       990      1000      1010      1020
pF1KB7 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL
     960       970       980       990      1000      1010         

             1030      1040      1050      1060      1070      1080
pF1KB7 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG
    1020      1030      1040      1050      1060      1070         

             1090      1100      1110      1120      1130      1140
pF1KB7 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM
    1080      1090      1100      1110      1120      1130         

             1150      1160      1170      1180      1190      1200
pF1KB7 AAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAE
    1140      1150      1160      1170      1180      1190         

             1210      1220      1230      1240      1250      1260
pF1KB7 ANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFE
    1200      1210      1220      1230      1240      1250         

             1270      1280      1290      1300      1310      1320
pF1KB7 LQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKN
    1260      1270      1280      1290      1300      1310         

             1330      1340      1350      1360      1370      1380
pF1KB7 RKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNS
    1320      1330      1340      1350      1360      1370         

             1390      1400      1410      1420      1430      1440
pF1KB7 SRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLSTCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLSTCT
    1380      1390      1400      1410      1420      1430         

             1450      1460      1470      1480      1490      1500
pF1KB7 KSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAI
    1440      1450      1460      1470      1480      1490         

             1510      1520      1530      1540      1550      1560
pF1KB7 REFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKS
    1500      1510      1520      1530      1540      1550         

             1570      1580      1590      1600      1610      1620
pF1KB7 SSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVN
    1560      1570      1580      1590      1600      1610         

             1630      1640      1650      1660      1670      1680
pF1KB7 NVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRP
    1620      1630      1640      1650      1660      1670         

             1690      1700      1710      1720      1730      1740
pF1KB7 LSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSS
    1680      1690      1700      1710      1720      1730         

             1750      1760      1770      1780      1790      1800
pF1KB7 PSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ
    1740      1750      1760      1770      1780      1790         

             1810      1820      1830      1840      1850      1860
pF1KB7 PGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQP
    1800      1810      1820      1830      1840      1850         

             1870      1880      1890      1900      1910      1920
pF1KB7 PGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTP
    1860      1870      1880      1890      1900      1910         

             1930      1940      1950      1960      1970      1980
pF1KB7 KMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSACQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSACQ
    1920      1930      1940      1950      1960      1970         

             1990      2000      2010      2020      2030      2040
pF1KB7 NSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYL
    1980      1990      2000      2010      2020      2030         

             2050      2060      2070      2080      2090      2100
pF1KB7 PNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQM
    2040      2050      2060      2070      2080      2090         

             2110      2120      2130      2140      2150      2160
pF1KB7 YGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPLGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPLGS
    2100      2110      2120      2130      2140      2150         

             2170      2180      2190      2200      2210      2220
pF1KB7 EKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDK
    2160      2170      2180      2190      2200      2210         

             2230      2240      2250      2260      2270      2280
pF1KB7 VDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGM
    2220      2230      2240      2250      2260      2270         

             2290      2300      2310      2320      2330      2340
pF1KB7 PFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGPWA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGPWA
    2280      2290      2300      2310      2320      2330         

             2350  
pF1KB7 PHMNSVHMNQLG
       ::::::::::::
XP_005 PHMNSVHMNQLG
    2340      2350 

>>XP_016863501 (OMIM: 615929) PREDICTED: ankyrin repeat   (2239 aa)
 initn: 14514 init1: 14514 opt: 14514  Z-score: 5175.2  bits: 971.5 E(85289):    0
Smith-Waterman score: 14514; 99.9% identity (100.0% similar) in 2226 aa overlap (127-2352:14-2239)

        100       110       120       130       140       150      
pF1KB7 GGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLS
                                     :.. ::::::::::::::::::::::::::
XP_016                  MVETAAEMEAYVLEDILEVESFILDQDDLENPMLETASKLLLS
                                10        20        30        40   

        160       170       180       190       200       210      
pF1KB7 GTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAA
            50        60        70        80        90       100   

        220       230       240       250       260       270      
pF1KB7 AALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACS
           110       120       130       140       150       160   

        280       290       300       310       320       330      
pF1KB7 AGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNT
           170       180       190       200       210       220   

        340       350       360       370       380       390      
pF1KB7 ALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH
           230       240       250       260       270       280   

        400       410       420       430       440       450      
pF1KB7 SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS
           290       300       310       320       330       340   

        460       470       480       490       500       510      
pF1KB7 GAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV
           350       360       370       380       390       400   

        520       530       540       550       560       570      
pF1KB7 ALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH
           410       420       430       440       450       460   

        580       590       600       610       620       630      
pF1KB7 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK
           470       480       490       500       510       520   

        640       650       660       670       680       690      
pF1KB7 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD
           530       540       550       560       570       580   

        700       710       720       730       740       750      
pF1KB7 GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVV
           590       600       610       620       630       640   

        760       770       780       790       800       810      
pF1KB7 PPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAML
           650       660       670       680       690       700   

        820       830       840       850       860       870      
pF1KB7 PIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAG
           710       720       730       740       750       760   

        880       890       900       910       920       930      
pF1KB7 HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL
           770       780       790       800       810       820   

        940       950       960       970       980       990      
pF1KB7 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ
           830       840       850       860       870       880   

       1000      1010      1020      1030      1040      1050      
pF1KB7 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK
           890       900       910       920       930       940   

       1060      1070      1080      1090      1100      1110      
pF1KB7 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD
           950       960       970       980       990      1000   

       1120      1130      1140      1150      1160      1170      
pF1KB7 VVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITD
          1010      1020      1030      1040      1050      1060   

       1180      1190      1200      1210      1220      1230      
pF1KB7 KEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEK
          1070      1080      1090      1100      1110      1120   

       1240      1250      1260      1270      1280      1290      
pF1KB7 RRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISAT
          1130      1140      1150      1160      1170      1180   

       1300      1310      1320      1330      1340      1350      
pF1KB7 WTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSS
          1190      1200      1210      1220      1230      1240   

       1360      1370      1380      1390      1400      1410      
pF1KB7 TSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSV
          1250      1260      1270      1280      1290      1300   

       1420      1430      1440      1450      1460      1470      
pF1KB7 SGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRS
          1310      1320      1330      1340      1350      1360   

       1480      1490      1500      1510      1520      1530      
pF1KB7 KKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQ
          1370      1380      1390      1400      1410      1420   

       1540      1550      1560      1570      1580      1590      
pF1KB7 LINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQ
          1430      1440      1450      1460      1470      1480   

       1600      1610      1620      1630      1640      1650      
pF1KB7 TATALTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TATALTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPR
          1490      1500      1510      1520      1530      1540   

       1660      1670      1680      1690      1700      1710      
pF1KB7 LPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTS
          1550      1560      1570      1580      1590      1600   

       1720      1730      1740      1750      1760      1770      
pF1KB7 SPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNA
          1610      1620      1630      1640      1650      1660   

       1780      1790      1800      1810      1820      1830      
pF1KB7 TYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVET
          1670      1680      1690      1700      1710      1720   

       1840      1850      1860      1870      1880      1890      
pF1KB7 TNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPV
          1730      1740      1750      1760      1770      1780   

       1900      1910      1920      1930      1940      1950      
pF1KB7 AVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNH
          1790      1800      1810      1820      1830      1840   

       1960      1970      1980      1990      2000      2010      
pF1KB7 IKRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHA
          1850      1860      1870      1880      1890      1900   

       2020      2030      2040      2050      2060      2070      
pF1KB7 FWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDS
          1910      1920      1930      1940      1950      1960   

       2080      2090      2100      2110      2120      2130      
pF1KB7 PYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASND
          1970      1980      1990      2000      2010      2020   

       2140      2150      2160      2170      2180      2190      
pF1KB7 SSAQSVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSAQSVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIG
          2030      2040      2050      2060      2070      2080   

       2200      2210      2220      2230      2240      2250      
pF1KB7 SNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGI
          2090      2100      2110      2120      2130      2140   

       2260      2270      2280      2290      2300      2310      
pF1KB7 VTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWN
          2150      2160      2170      2180      2190      2200   

       2320      2330      2340      2350  
pF1KB7 SLIKMVSSSTENNGPQTVWTGPWAPHMNSVHMNQLG
       ::::::::::::::::::::::::::::::::::::
XP_016 SLIKMVSSSTENNGPQTVWTGPWAPHMNSVHMNQLG
          2210      2220      2230         

>>XP_016863502 (OMIM: 615929) PREDICTED: ankyrin repeat   (2238 aa)
 initn: 14495 init1: 10328 opt: 14497  Z-score: 5169.1  bits: 970.4 E(85289):    0
Smith-Waterman score: 14497; 99.8% identity (99.9% similar) in 2226 aa overlap (127-2352:14-2238)

        100       110       120       130       140       150      
pF1KB7 GGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLS
                                     :.. ::::::::::::::::::::::::::
XP_016                  MVETAAEMEAYVLEDILEVESFILDQDDLENPMLETASKLLLS
                                10        20        30        40   

        160       170       180       190       200       210      
pF1KB7 GTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAA
            50        60        70        80        90       100   

        220       230       240       250       260       270      
pF1KB7 AALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACS
           110       120       130       140       150       160   

        280       290       300       310       320       330      
pF1KB7 AGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNT
           170       180       190       200       210       220   

        340       350       360       370       380       390      
pF1KB7 ALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH
           230       240       250       260       270       280   

        400       410       420       430       440       450      
pF1KB7 SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS
           290       300       310       320       330       340   

        460       470       480       490       500       510      
pF1KB7 GAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV
           350       360       370       380       390       400   

        520       530       540       550       560       570      
pF1KB7 ALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH
           410       420       430       440       450       460   

        580       590       600       610       620       630      
pF1KB7 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK
           470       480       490       500       510       520   

        640       650       660       670       680       690      
pF1KB7 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD
           530       540       550       560       570       580   

        700       710       720       730       740       750      
pF1KB7 GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVV
           590       600       610       620       630       640   

        760       770       780       790       800       810      
pF1KB7 PPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAML
       ::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
XP_016 PPQEPDKPPANVATTLPIRNK-VSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAML
           650       660        670       680       690       700  

        820       830       840       850       860       870      
pF1KB7 PIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAG
            710       720       730       740       750       760  

        880       890       900       910       920       930      
pF1KB7 HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL
            770       780       790       800       810       820  

        940       950       960       970       980       990      
pF1KB7 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ
            830       840       850       860       870       880  

       1000      1010      1020      1030      1040      1050      
pF1KB7 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK
            890       900       910       920       930       940  

       1060      1070      1080      1090      1100      1110      
pF1KB7 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD
            950       960       970       980       990      1000  

       1120      1130      1140      1150      1160      1170      
pF1KB7 VVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITD
           1010      1020      1030      1040      1050      1060  

       1180      1190      1200      1210      1220      1230      
pF1KB7 KEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEK
           1070      1080      1090      1100      1110      1120  

       1240      1250      1260      1270      1280      1290      
pF1KB7 RRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISAT
           1130      1140      1150      1160      1170      1180  

       1300      1310      1320      1330      1340      1350      
pF1KB7 WTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSS
           1190      1200      1210      1220      1230      1240  

       1360      1370      1380      1390      1400      1410      
pF1KB7 TSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSV
           1250      1260      1270      1280      1290      1300  

       1420      1430      1440      1450      1460      1470      
pF1KB7 SGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRS
           1310      1320      1330      1340      1350      1360  

       1480      1490      1500      1510      1520      1530      
pF1KB7 KKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQ
           1370      1380      1390      1400      1410      1420  

       1540      1550      1560      1570      1580      1590      
pF1KB7 LINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQ
           1430      1440      1450      1460      1470      1480  

       1600      1610      1620      1630      1640      1650      
pF1KB7 TATALTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TATALTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPR
           1490      1500      1510      1520      1530      1540  

       1660      1670      1680      1690      1700      1710      
pF1KB7 LPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTS
           1550      1560      1570      1580      1590      1600  

       1720      1730      1740      1750      1760      1770      
pF1KB7 SPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNA
           1610      1620      1630      1640      1650      1660  

       1780      1790      1800      1810      1820      1830      
pF1KB7 TYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVET
           1670      1680      1690      1700      1710      1720  

       1840      1850      1860      1870      1880      1890      
pF1KB7 TNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPV
           1730      1740      1750      1760      1770      1780  

       1900      1910      1920      1930      1940      1950      
pF1KB7 AVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNH
           1790      1800      1810      1820      1830      1840  

       1960      1970      1980      1990      2000      2010      
pF1KB7 IKRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHA
           1850      1860      1870      1880      1890      1900  

       2020      2030      2040      2050      2060      2070      
pF1KB7 FWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDS
           1910      1920      1930      1940      1950      1960  

       2080      2090      2100      2110      2120      2130      
pF1KB7 PYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASND
           1970      1980      1990      2000      2010      2020  

       2140      2150      2160      2170      2180      2190      
pF1KB7 SSAQSVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSAQSVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIG
           2030      2040      2050      2060      2070      2080  

       2200      2210      2220      2230      2240      2250      
pF1KB7 SNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGI
           2090      2100      2110      2120      2130      2140  

       2260      2270      2280      2290      2300      2310      
pF1KB7 VTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWN
           2150      2160      2170      2180      2190      2200  

       2320      2330      2340      2350  
pF1KB7 SLIKMVSSSTENNGPQTVWTGPWAPHMNSVHMNQLG
       ::::::::::::::::::::::::::::::::::::
XP_016 SLIKMVSSSTENNGPQTVWTGPWAPHMNSVHMNQLG
           2210      2220      2230        

>>NP_001273700 (OMIM: 615929) ankyrin repeat domain-cont  (2490 aa)
 initn: 10333 init1: 10333 opt: 10338  Z-score: 3691.2  bits: 697.1 E(85289): 7.3e-199
Smith-Waterman score: 13449; 89.5% identity (89.5% similar) in 2384 aa overlap (220-2352:107-2490)

     190       200       210       220       230       240         
pF1KB7 ADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA
                                     ::::::::::::::::::::::::::::::
NP_001 ADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA
         80        90       100       110       120       130      

     250       260       270       280       290       300         
pF1KB7 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA
        140       150       160       170       180       190      

     310       320       330       340       350       360         
pF1KB7 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT
        200       210       220       230       240       250      

     370       380       390       400       410       420         
pF1KB7 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEH
        260       270       280       290       300       310      

     430       440       450       460       470       480         
pF1KB7 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER
        320       330       340       350       360       370      

     490       500       510       520       530       540         
pF1KB7 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV
        380       390       400       410       420       430      

     550       560       570       580       590       600         
pF1KB7 ADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGH
        440       450       460       470       480       490      

     610       620       630       640       650       660         
pF1KB7 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLS
        500       510       520       530       540       550      

     670       680       690       700       710       720         
pF1KB7 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPP
        560       570       580       590       600       610      

     730       740       750       760       770                   
pF1KB7 DVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKA-----------
       :::::::::::::::::::::::::::::::::::::::::::::::::           
NP_001 DVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHLP
        620       630       640       650       660       670      

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
NP_001 ANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIE
        680       690       700       710       720       730      

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
NP_001 ELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQHL
        740       750       760       770       780       790      

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
NP_001 GLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGPL
        800       810       820       830       840       850      

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
NP_001 PPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAA
        860       870       880       890       900       910      

      780       790       800       810       820       830        
pF1KB7 VSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTL
        920       930       940       950       960       970      

      840       850       860       870       880       890        
pF1KB7 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT
        980       990      1000      1010      1020      1030      

      900       910       920       930       940       950        
pF1KB7 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI
       1040      1050      1060      1070      1080      1090      

      960       970       980       990      1000      1010        
pF1KB7 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS
       1100      1110      1120      1130      1140      1150      

     1020      1030      1040      1050      1060      1070        
pF1KB7 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD
       1160      1170      1180      1190      1200      1210      

     1080      1090      1100      1110      1120      1130        
pF1KB7 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP
       1220      1230      1240      1250      1260      1270      

     1140      1150      1160      1170      1180      1190        
pF1KB7 LMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQA
       1280      1290      1300      1310      1320      1330      

     1200      1210      1220      1230      1240      1250        
pF1KB7 AEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKEN
       1340      1350      1360      1370      1380      1390      

     1260      1270      1280      1290      1300      1310        
pF1KB7 FELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKR
       1400      1410      1420      1430      1440      1450      

     1320      1330      1340      1350      1360      1370        
pF1KB7 KNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNS
       1460      1470      1480      1490      1500      1510      

     1380      1390      1400      1410      1420      1430        
pF1KB7 NSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLST
       1520      1530      1540      1550      1560      1570      

     1440      1450      1460      1470      1480      1490        
pF1KB7 CTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNIN
       1580      1590      1600      1610      1620      1630      

     1500      1510      1520      1530      1540      1550        
pF1KB7 AIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRL
       1640      1650      1660      1670      1680      1690      

     1560      1570      1580      1590      1600      1610        
pF1KB7 KSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNP
       1700      1710      1720      1730      1740      1750      

     1620      1630      1640      1650      1660      1670        
pF1KB7 VNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPV
       1760      1770      1780      1790      1800      1810      

     1680      1690      1700      1710      1720      1730        
pF1KB7 RPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSP
       1820      1830      1840      1850      1860      1870      

     1740      1750      1760      1770      1780      1790        
pF1KB7 SSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPP
       1880      1890      1900      1910      1920      1930      

     1800      1810      1820      1830      1840      1850        
pF1KB7 AQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQ
       1940      1950      1960      1970      1980      1990      

     1860      1870      1880      1890      1900      1910        
pF1KB7 QPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQP
       2000      2010      2020      2030      2040      2050      

     1920      1930      1940      1950      1960      1970        
pF1KB7 TPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSA
       2060      2070      2080      2090      2100      2110      

     1980      1990      2000      2010      2020      2030        
pF1KB7 CQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSS
       2120      2130      2140      2150      2160      2170      

     2040      2050      2060      2070      2080      2090        
pF1KB7 YLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGG
       2180      2190      2200      2210      2220      2230      

     2100      2110      2120      2130      2140      2150        
pF1KB7 QMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPL
       2240      2250      2260      2270      2280      2290      

     2160      2170      2180      2190      2200      2210        
pF1KB7 GSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQ
       2300      2310      2320      2330      2340      2350      

     2220      2230      2240      2250      2260      2270        
pF1KB7 DKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVG
       2360      2370      2380      2390      2400      2410      

     2280      2290      2300      2310      2320      2330        
pF1KB7 GMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGP
       2420      2430      2440      2450      2460      2470      

     2340      2350  
pF1KB7 WAPHMNSVHMNQLG
       ::::::::::::::
NP_001 WAPHMNSVHMNQLG
       2480      2490

>--
 initn: 553 init1: 553 opt: 553  Z-score: 215.5  bits: 53.9 E(85289): 2.9e-05
Smith-Waterman score: 553; 96.8% identity (98.9% similar) in 93 aa overlap (127-219:14-106)

        100       110       120       130       140       150      
pF1KB7 GGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLS
                                     :.. ::::::::::::::::::::::::::
NP_001                  MVETAAEMEAYVLEDILEVESFILDQDDLENPMLETASKLLLS
                                10        20        30        40   

        160       170       180       190       200       210      
pF1KB7 GTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAA
            50        60        70        80        90       100   

        220       230       240       250       260       270      
pF1KB7 AALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACS
       :::                                                         
NP_001 AALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACS
           110       120       130       140       150       160   

>>NP_115593 (OMIM: 615929) ankyrin repeat domain-contain  (2603 aa)
 initn: 10333 init1: 10333 opt: 10338  Z-score: 3690.9  bits: 697.1 E(85289): 7.6e-199
Smith-Waterman score: 13449; 89.5% identity (89.5% similar) in 2384 aa overlap (220-2352:220-2603)

     190       200       210       220       230       240         
pF1KB7 ADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA
                                     ::::::::::::::::::::::::::::::
NP_115 ADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA
     190       200       210       220       230       240         

     250       260       270       280       290       300         
pF1KB7 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA
     250       260       270       280       290       300         

     310       320       330       340       350       360         
pF1KB7 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT
     310       320       330       340       350       360         

     370       380       390       400       410       420         
pF1KB7 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEH
     370       380       390       400       410       420         

     430       440       450       460       470       480         
pF1KB7 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER
     430       440       450       460       470       480         

     490       500       510       520       530       540         
pF1KB7 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV
     490       500       510       520       530       540         

     550       560       570       580       590       600         
pF1KB7 ADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 ADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGH
     550       560       570       580       590       600         

     610       620       630       640       650       660         
pF1KB7 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLS
     610       620       630       640       650       660         

     670       680       690       700       710       720         
pF1KB7 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPP
     670       680       690       700       710       720         

     730       740       750       760       770                   
pF1KB7 DVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKA-----------
       :::::::::::::::::::::::::::::::::::::::::::::::::           
NP_115 DVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHLP
     730       740       750       760       770       780         

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
NP_115 ANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIE
     790       800       810       820       830       840         

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
NP_115 ELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQHL
     850       860       870       880       890       900         

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
NP_115 GLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGPL
     910       920       930       940       950       960         

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
NP_115 PPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAA
     970       980       990      1000      1010      1020         

      780       790       800       810       820       830        
pF1KB7 VSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 VSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTL
    1030      1040      1050      1060      1070      1080         

      840       850       860       870       880       890        
pF1KB7 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT
    1090      1100      1110      1120      1130      1140         

      900       910       920       930       940       950        
pF1KB7 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI
    1150      1160      1170      1180      1190      1200         

      960       970       980       990      1000      1010        
pF1KB7 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS
    1210      1220      1230      1240      1250      1260         

     1020      1030      1040      1050      1060      1070        
pF1KB7 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD
    1270      1280      1290      1300      1310      1320         

     1080      1090      1100      1110      1120      1130        
pF1KB7 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP
    1330      1340      1350      1360      1370      1380         

     1140      1150      1160      1170      1180      1190        
pF1KB7 LMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQA
    1390      1400      1410      1420      1430      1440         

     1200      1210      1220      1230      1240      1250        
pF1KB7 AEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 AEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKEN
    1450      1460      1470      1480      1490      1500         

     1260      1270      1280      1290      1300      1310        
pF1KB7 FELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 FELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKR
    1510      1520      1530      1540      1550      1560         

     1320      1330      1340      1350      1360      1370        
pF1KB7 KNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNS
    1570      1580      1590      1600      1610      1620         

     1380      1390      1400      1410      1420      1430        
pF1KB7 NSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 NSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLST
    1630      1640      1650      1660      1670      1680         

     1440      1450      1460      1470      1480      1490        
pF1KB7 CTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 CTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNIN
    1690      1700      1710      1720      1730      1740         

     1500      1510      1520      1530      1540      1550        
pF1KB7 AIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 AIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRL
    1750      1760      1770      1780      1790      1800         

     1560      1570      1580      1590      1600      1610        
pF1KB7 KSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNP
    1810      1820      1830      1840      1850      1860         

     1620      1630      1640      1650      1660      1670        
pF1KB7 VNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 VNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPV
    1870      1880      1890      1900      1910      1920         

     1680      1690      1700      1710      1720      1730        
pF1KB7 RPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 RPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSP
    1930      1940      1950      1960      1970      1980         

     1740      1750      1760      1770      1780      1790        
pF1KB7 SSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPP
    1990      2000      2010      2020      2030      2040         

     1800      1810      1820      1830      1840      1850        
pF1KB7 AQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 AQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQ
    2050      2060      2070      2080      2090      2100         

     1860      1870      1880      1890      1900      1910        
pF1KB7 QPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 QPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQP
    2110      2120      2130      2140      2150      2160         

     1920      1930      1940      1950      1960      1970        
pF1KB7 TPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSA
    2170      2180      2190      2200      2210      2220         

     1980      1990      2000      2010      2020      2030        
pF1KB7 CQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 CQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSS
    2230      2240      2250      2260      2270      2280         

     2040      2050      2060      2070      2080      2090        
pF1KB7 YLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 YLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGG
    2290      2300      2310      2320      2330      2340         

     2100      2110      2120      2130      2140      2150        
pF1KB7 QMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 QMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPL
    2350      2360      2370      2380      2390      2400         

     2160      2170      2180      2190      2200      2210        
pF1KB7 GSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQ
    2410      2420      2430      2440      2450      2460         

     2220      2230      2240      2250      2260      2270        
pF1KB7 DKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 DKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVG
    2470      2480      2490      2500      2510      2520         

     2280      2290      2300      2310      2320      2330        
pF1KB7 GMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGP
    2530      2540      2550      2560      2570      2580         

     2340      2350  
pF1KB7 WAPHMNSVHMNQLG
       ::::::::::::::
NP_115 WAPHMNSVHMNQLG
    2590      2600   

>--
 initn: 1414 init1: 1414 opt: 1414  Z-score: 521.0  bits: 110.5 E(85289): 2.8e-22
Smith-Waterman score: 1414; 100.0% identity (100.0% similar) in 219 aa overlap (1-219:1-219)

               10        20        30        40        50        60
pF1KB7 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
       :::::::::::::::::::::::::::::::::::::::                     
NP_115 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
                                                                   
NP_115 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
              250       260       270       280       290       300

>>XP_016863500 (OMIM: 615929) PREDICTED: ankyrin repeat   (2489 aa)
 initn: 10333 init1: 10333 opt: 10333  Z-score: 3689.4  bits: 696.7 E(85289): 9.2e-199
Smith-Waterman score: 13456; 89.5% identity (89.5% similar) in 2384 aa overlap (219-2352:106-2489)

      190       200       210       220       230       240        
pF1KB7 TADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVN
                                     ::::::::::::::::::::::::::::::
XP_016 TADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVN
          80        90       100       110       120       130     

      250       260       270       280       290       300        
pF1KB7 AVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAA
         140       150       160       170       180       190     

      310       320       330       340       350       360        
pF1KB7 ANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGH
         200       210       220       230       240       250     

      370       380       390       400       410       420        
pF1KB7 TPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQE
         260       270       280       290       300       310     

      430       440       450       460       470       480        
pF1KB7 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE
         320       330       340       350       360       370     

      490       500       510       520       530       540        
pF1KB7 RGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLE
         380       390       400       410       420       430     

      550       560       570       580       590       600        
pF1KB7 VADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENG
         440       450       460       470       480       490     

      610       620       630       640       650       660        
pF1KB7 HTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVL
         500       510       520       530       540       550     

      670       680       690       700       710       720        
pF1KB7 SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPP
         560       570       580       590       600       610     

      730       740       750       760       770                  
pF1KB7 PDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKA----------
       ::::::::::::::::::::::::::::::::::::::::::::::::::          
XP_016 PDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHL
         620       630       640       650       660       670     

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
XP_016 PANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKI
         680       690       700       710       720       730     

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
XP_016 EELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQH
         740       750       760       770       780       790     

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
XP_016 LGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGP
         800       810       820       830       840       850     

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
XP_016 LPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMA
         860       870       880       890       900       910     

      780       790       800       810       820       830        
pF1KB7 VSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTL
         920       930       940       950       960       970     

      840       850       860       870       880       890        
pF1KB7 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT
         980       990      1000      1010      1020      1030     

      900       910       920       930       940       950        
pF1KB7 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI
        1040      1050      1060      1070      1080      1090     

      960       970       980       990      1000      1010        
pF1KB7 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS
        1100      1110      1120      1130      1140      1150     

     1020      1030      1040      1050      1060      1070        
pF1KB7 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD
        1160      1170      1180      1190      1200      1210     

     1080      1090      1100      1110      1120      1130        
pF1KB7 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP
        1220      1230      1240      1250      1260      1270     

     1140      1150      1160      1170      1180      1190        
pF1KB7 LMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQA
        1280      1290      1300      1310      1320      1330     

     1200      1210      1220      1230      1240      1250        
pF1KB7 AEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKEN
        1340      1350      1360      1370      1380      1390     

     1260      1270      1280      1290      1300      1310        
pF1KB7 FELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKR
        1400      1410      1420      1430      1440      1450     

     1320      1330      1340      1350      1360      1370        
pF1KB7 KNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNS
        1460      1470      1480      1490      1500      1510     

     1380      1390      1400      1410      1420      1430        
pF1KB7 NSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLST
        1520      1530      1540      1550      1560      1570     

     1440      1450      1460      1470      1480      1490        
pF1KB7 CTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNIN
        1580      1590      1600      1610      1620      1630     

     1500      1510      1520      1530      1540      1550        
pF1KB7 AIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRL
        1640      1650      1660      1670      1680      1690     

     1560      1570      1580      1590      1600      1610        
pF1KB7 KSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNP
        1700      1710      1720      1730      1740      1750     

     1620      1630      1640      1650      1660      1670        
pF1KB7 VNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPV
        1760      1770      1780      1790      1800      1810     

     1680      1690      1700      1710      1720      1730        
pF1KB7 RPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSP
        1820      1830      1840      1850      1860      1870     

     1740      1750      1760      1770      1780      1790        
pF1KB7 SSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPP
        1880      1890      1900      1910      1920      1930     

     1800      1810      1820      1830      1840      1850        
pF1KB7 AQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQ
        1940      1950      1960      1970      1980      1990     

     1860      1870      1880      1890      1900      1910        
pF1KB7 QPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQP
        2000      2010      2020      2030      2040      2050     

     1920      1930      1940      1950      1960      1970        
pF1KB7 TPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSA
        2060      2070      2080      2090      2100      2110     

     1980      1990      2000      2010      2020      2030        
pF1KB7 CQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSS
        2120      2130      2140      2150      2160      2170     

     2040      2050      2060      2070      2080      2090        
pF1KB7 YLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGG
        2180      2190      2200      2210      2220      2230     

     2100      2110      2120      2130      2140      2150        
pF1KB7 QMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPL
        2240      2250      2260      2270      2280      2290     

     2160      2170      2180      2190      2200      2210        
pF1KB7 GSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQ
        2300      2310      2320      2330      2340      2350     

     2220      2230      2240      2250      2260      2270        
pF1KB7 DKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVG
        2360      2370      2380      2390      2400      2410     

     2280      2290      2300      2310      2320      2330        
pF1KB7 GMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGP
        2420      2430      2440      2450      2460      2470     

     2340      2350  
pF1KB7 WAPHMNSVHMNQLG
       ::::::::::::::
XP_016 WAPHMNSVHMNQLG
        2480         

>--
 initn: 548 init1: 548 opt: 548  Z-score: 213.7  bits: 53.6 E(85289): 3.6e-05
Smith-Waterman score: 548; 96.7% identity (98.9% similar) in 92 aa overlap (127-218:14-105)

        100       110       120       130       140       150      
pF1KB7 GGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLS
                                     :.. ::::::::::::::::::::::::::
XP_016                  MVETAAEMEAYVLEDILEVESFILDQDDLENPMLETASKLLLS
                                10        20        30        40   

        160       170       180       190       200       210      
pF1KB7 GTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAA
            50        60        70        80        90       100   

        220       230       240       250       260       270      
pF1KB7 AALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACS
       ::                                                          
XP_016 AALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACS
           110       120       130       140       150       160   

>>NP_056389 (OMIM: 615929) ankyrin repeat domain-contain  (2602 aa)
 initn: 10333 init1: 10333 opt: 10333  Z-score: 3689.2  bits: 696.7 E(85289): 9.5e-199
Smith-Waterman score: 13456; 89.5% identity (89.5% similar) in 2384 aa overlap (219-2352:219-2602)

      190       200       210       220       230       240        
pF1KB7 TADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVN
                                     ::::::::::::::::::::::::::::::
NP_056 TADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVN
      190       200       210       220       230       240        

      250       260       270       280       290       300        
pF1KB7 AVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAA
      250       260       270       280       290       300        

      310       320       330       340       350       360        
pF1KB7 ANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGH
      310       320       330       340       350       360        

      370       380       390       400       410       420        
pF1KB7 TPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQE
      370       380       390       400       410       420        

      430       440       450       460       470       480        
pF1KB7 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE
      430       440       450       460       470       480        

      490       500       510       520       530       540        
pF1KB7 RGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 RGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLE
      490       500       510       520       530       540        

      550       560       570       580       590       600        
pF1KB7 VADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENG
      550       560       570       580       590       600        

      610       620       630       640       650       660        
pF1KB7 HTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVL
      610       620       630       640       650       660        

      670       680       690       700       710       720        
pF1KB7 SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPP
      670       680       690       700       710       720        

      730       740       750       760       770                  
pF1KB7 PDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKA----------
       ::::::::::::::::::::::::::::::::::::::::::::::::::          
NP_056 PDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHL
      730       740       750       760       770       780        

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
NP_056 PANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKI
      790       800       810       820       830       840        

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
NP_056 EELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQH
      850       860       870       880       890       900        

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
NP_056 LGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGP
      910       920       930       940       950       960        

                                                                   
pF1KB7 ------------------------------------------------------------
                                                                   
NP_056 LPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMA
      970       980       990      1000      1010      1020        

      780       790       800       810       820       830        
pF1KB7 VSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTL
     1030      1040      1050      1060      1070      1080        

      840       850       860       870       880       890        
pF1KB7 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT
     1090      1100      1110      1120      1130      1140        

      900       910       920       930       940       950        
pF1KB7 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI
     1150      1160      1170      1180      1190      1200        

      960       970       980       990      1000      1010        
pF1KB7 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS
     1210      1220      1230      1240      1250      1260        

     1020      1030      1040      1050      1060      1070        
pF1KB7 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD
     1270      1280      1290      1300      1310      1320        

     1080      1090      1100      1110      1120      1130        
pF1KB7 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP
     1330      1340      1350      1360      1370      1380        

     1140      1150      1160      1170      1180      1190        
pF1KB7 LMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQA
     1390      1400      1410      1420      1430      1440        

     1200      1210      1220      1230      1240      1250        
pF1KB7 AEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKEN
     1450      1460      1470      1480      1490      1500        

     1260      1270      1280      1290      1300      1310        
pF1KB7 FELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKR
     1510      1520      1530      1540      1550      1560        

     1320      1330      1340      1350      1360      1370        
pF1KB7 KNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNS
     1570      1580      1590      1600      1610      1620        

     1380      1390      1400      1410      1420      1430        
pF1KB7 NSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLST
     1630      1640      1650      1660      1670      1680        

     1440      1450      1460      1470      1480      1490        
pF1KB7 CTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 CTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNIN
     1690      1700      1710      1720      1730      1740        

     1500      1510      1520      1530      1540      1550        
pF1KB7 AIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRL
     1750      1760      1770      1780      1790      1800        

     1560      1570      1580      1590      1600      1610        
pF1KB7 KSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNP
     1810      1820      1830      1840      1850      1860        

     1620      1630      1640      1650      1660      1670        
pF1KB7 VNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPV
     1870      1880      1890      1900      1910      1920        

     1680      1690      1700      1710      1720      1730        
pF1KB7 RPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 RPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSP
     1930      1940      1950      1960      1970      1980        

     1740      1750      1760      1770      1780      1790        
pF1KB7 SSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPP
     1990      2000      2010      2020      2030      2040        

     1800      1810      1820      1830      1840      1850        
pF1KB7 AQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQ
     2050      2060      2070      2080      2090      2100        

     1860      1870      1880      1890      1900      1910        
pF1KB7 QPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQP
     2110      2120      2130      2140      2150      2160        

     1920      1930      1940      1950      1960      1970        
pF1KB7 TPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSA
     2170      2180      2190      2200      2210      2220        

     1980      1990      2000      2010      2020      2030        
pF1KB7 CQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 CQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSS
     2230      2240      2250      2260      2270      2280        

     2040      2050      2060      2070      2080      2090        
pF1KB7 YLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 YLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGG
     2290      2300      2310      2320      2330      2340        

     2100      2110      2120      2130      2140      2150        
pF1KB7 QMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPL
     2350      2360      2370      2380      2390      2400        

     2160      2170      2180      2190      2200      2210        
pF1KB7 GSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQ
     2410      2420      2430      2440      2450      2460        

     2220      2230      2240      2250      2260      2270        
pF1KB7 DKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVG
     2470      2480      2490      2500      2510      2520        

     2280      2290      2300      2310      2320      2330        
pF1KB7 GMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGP
     2530      2540      2550      2560      2570      2580        

     2340      2350  
pF1KB7 WAPHMNSVHMNQLG
       ::::::::::::::
NP_056 WAPHMNSVHMNQLG
     2590      2600  

>--
 initn: 1409 init1: 1409 opt: 1409  Z-score: 519.3  bits: 110.2 E(85289): 3.5e-22
Smith-Waterman score: 1409; 100.0% identity (100.0% similar) in 218 aa overlap (1-218:1-218)

               10        20        30        40        50        60
pF1KB7 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
       ::::::::::::::::::::::::::::::::::::::                      
NP_056 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
                                                                   
NP_056 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
              250       260       270       280       290       300

>>XP_016863505 (OMIM: 615929) PREDICTED: ankyrin repeat   (1229 aa)
 initn: 7847 init1: 7847 opt: 7847  Z-score: 2810.5  bits: 533.1 E(85289): 8.3e-150
Smith-Waterman score: 7847; 100.0% identity (100.0% similar) in 1216 aa overlap (1-1216:1-1216)

               10        20        30        40        50        60
pF1KB7 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB7 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB7 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB7 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB7 GRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB7 AGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB7 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB7 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB7 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB7 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB7 AAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAE
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB7 ANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFE
       ::::::::::::::::                                            
XP_016 ANKNASILLEELDLEKADYNIIPIYSHGE                               
             1210      1220                                        

>>XP_016863506 (OMIM: 615929) PREDICTED: ankyrin repeat   (1116 aa)
 initn: 6986 init1: 6986 opt: 6986  Z-score: 2505.3  bits: 476.5 E(85289): 8.3e-133
Smith-Waterman score: 6986; 99.7% identity (99.9% similar) in 1090 aa overlap (127-1216:14-1103)

        100       110       120       130       140       150      
pF1KB7 GGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLS
                                     :.. ::::::::::::::::::::::::::
XP_016                  MVETAAEMEAYVLEDILEVESFILDQDDLENPMLETASKLLLS
                                10        20        30        40   

        160       170       180       190       200       210      
pF1KB7 GTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAA
            50        60        70        80        90       100   

        220       230       240       250       260       270      
pF1KB7 AALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACS
           110       120       130       140       150       160   

        280       290       300       310       320       330      
pF1KB7 AGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNT
           170       180       190       200       210       220   

        340       350       360       370       380       390      
pF1KB7 ALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH
           230       240       250       260       270       280   

        400       410       420       430       440       450      
pF1KB7 SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS
           290       300       310       320       330       340   

        460       470       480       490       500       510      
pF1KB7 GAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV
           350       360       370       380       390       400   

        520       530       540       550       560       570      
pF1KB7 ALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH
           410       420       430       440       450       460   

        580       590       600       610       620       630      
pF1KB7 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK
           470       480       490       500       510       520   

        640       650       660       670       680       690      
pF1KB7 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD
           530       540       550       560       570       580   

        700       710       720       730       740       750      
pF1KB7 GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVV
           590       600       610       620       630       640   

        760       770       780       790       800       810      
pF1KB7 PPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAML
           650       660       670       680       690       700   

        820       830       840       850       860       870      
pF1KB7 PIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAG
           710       720       730       740       750       760   

        880       890       900       910       920       930      
pF1KB7 HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL
           770       780       790       800       810       820   

        940       950       960       970       980       990      
pF1KB7 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ
           830       840       850       860       870       880   

       1000      1010      1020      1030      1040      1050      
pF1KB7 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK
           890       900       910       920       930       940   

       1060      1070      1080      1090      1100      1110      
pF1KB7 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD
           950       960       970       980       990      1000   

       1120      1130      1140      1150      1160      1170      
pF1KB7 VVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITD
          1010      1020      1030      1040      1050      1060   

       1180      1190      1200      1210      1220      1230      
pF1KB7 KEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEK
       ::::::::::::::::::::::::::::::::::::::::                    
XP_016 KEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKADYNIIPIYSHGE       
          1070      1080      1090      1100      1110             

       1240      1250      1260      1270      1280      1290      
pF1KB7 RRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISAT




2352 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 13:32:25 2016 done: Sat Nov  5 13:32:28 2016
 Total Scan time: 20.020 Total Display time:  1.640

Function used was FASTA [36.3.4 Apr, 2011]
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