Result of FASTA (omim) for pF1KB8959
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8959, 338 aa
  1>>>pF1KB8959 338 - 338 aa - 338 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.2221+/-0.000402; mu= 13.6023+/- 0.025
 mean_var=143.4455+/-28.976, 0's: 0 Z-trim(116.0): 119  B-trim: 76 in 2/50
 Lambda= 0.107086
 statistics sampled from 26763 (26887) to 26763 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.315), width:  16
 Scan time:  8.190

The best scores are:                                      opt bits E(85289)
NP_002691 (OMIM: 602459,602460) POU domain, class  ( 338) 2257 360.3 3.4e-99
NP_004566 (OMIM: 113725) POU domain, class 4, tran ( 409) 1208 198.3 2.4e-50
NP_006228 (OMIM: 601632) POU domain, class 4, tran ( 419)  996 165.6 1.7e-40
NP_005595 (OMIM: 600494) POU domain, class 3, tran ( 443)  522 92.4   2e-18
NP_006227 (OMIM: 602480) POU domain, class 3, tran ( 500)  512 90.9 6.3e-18
NP_002690 (OMIM: 602479) POU domain, class 3, tran ( 451)  508 90.2   9e-18
NP_000298 (OMIM: 300039,304400) POU domain, class  ( 361)  496 88.3 2.8e-17
XP_016872976 (OMIM: 607394) PREDICTED: POU domain, ( 356)  492 87.6 4.3e-17
XP_011541044 (OMIM: 607394) PREDICTED: POU domain, ( 403)  492 87.7 4.6e-17
XP_011541045 (OMIM: 607394) PREDICTED: POU domain, ( 403)  492 87.7 4.6e-17
XP_011541043 (OMIM: 607394) PREDICTED: POU domain, ( 403)  492 87.7 4.6e-17
XP_011541042 (OMIM: 607394) PREDICTED: POU domain, ( 432)  492 87.7 4.9e-17
XP_011541041 (OMIM: 607394) PREDICTED: POU domain, ( 432)  492 87.7 4.9e-17
NP_055167 (OMIM: 607394) POU domain, class 2, tran ( 436)  492 87.7 4.9e-17
NP_001231611 (OMIM: 607394) POU domain, class 2, t ( 438)  492 87.7 4.9e-17
NP_000297 (OMIM: 173110,613038) pituitary-specific ( 291)  479 85.5 1.5e-16
NP_001116229 (OMIM: 173110,613038) pituitary-speci ( 317)  478 85.4 1.8e-16
XP_011507957 (OMIM: 164175) PREDICTED: POU domain, ( 671)  450 81.5 5.8e-15
NP_001185715 (OMIM: 164175) POU domain, class 2, t ( 703)  450 81.5   6e-15
XP_011507956 (OMIM: 164175) PREDICTED: POU domain, ( 743)  450 81.5 6.3e-15
NP_001185712 (OMIM: 164175) POU domain, class 2, t ( 755)  450 81.5 6.3e-15
NP_002688 (OMIM: 164175) POU domain, class 2, tran ( 766)  450 81.5 6.4e-15
XP_011507955 (OMIM: 164175) PREDICTED: POU domain, ( 769)  450 81.5 6.4e-15
NP_002692 (OMIM: 164177) POU domain, class 5, tran ( 360)  444 80.2 7.3e-15
NP_001272916 (OMIM: 164177) POU domain, class 5, t ( 265)  434 78.5 1.7e-14
NP_001153014 (OMIM: 615739) putative POU domain, c ( 359)  430 78.1 3.3e-14
NP_001159490 (OMIM: 601583,609062) POU domain, cla ( 655)  381 70.8 9.3e-12
NP_976034 (OMIM: 164177) POU domain, class 5, tran ( 190)  335 63.1 5.6e-10
NP_001167002 (OMIM: 164177) POU domain, class 5, t ( 190)  335 63.1 5.6e-10
NP_001193955 (OMIM: 164176) POU domain, class 2, t ( 467)  334 63.4 1.1e-09
NP_001193954 (OMIM: 164176) POU domain, class 2, t ( 479)  334 63.4 1.2e-09
XP_011525343 (OMIM: 164176) PREDICTED: POU domain, ( 501)  334 63.4 1.2e-09
XP_011525345 (OMIM: 164176) PREDICTED: POU domain, ( 537)  334 63.4 1.3e-09
XP_016882385 (OMIM: 164176) PREDICTED: POU domain, ( 600)  334 63.5 1.3e-09
XP_016882384 (OMIM: 164176) PREDICTED: POU domain, ( 602)  334 63.5 1.3e-09
XP_016882383 (OMIM: 164176) PREDICTED: POU domain, ( 602)  334 63.5 1.3e-09
XP_011525342 (OMIM: 164176) PREDICTED: POU domain, ( 624)  334 63.5 1.4e-09
XP_016882381 (OMIM: 164176) PREDICTED: POU domain, ( 701)  334 63.6 1.5e-09
XP_016882375 (OMIM: 164176) PREDICTED: POU domain, ( 711)  334 63.6 1.5e-09
XP_016882376 (OMIM: 164176) PREDICTED: POU domain, ( 711)  334 63.6 1.5e-09
XP_016882377 (OMIM: 164176) PREDICTED: POU domain, ( 711)  334 63.6 1.5e-09
XP_016882378 (OMIM: 164176) PREDICTED: POU domain, ( 711)  334 63.6 1.5e-09
XP_016882379 (OMIM: 164176) PREDICTED: POU domain, ( 711)  334 63.6 1.5e-09
XP_016882373 (OMIM: 164176) PREDICTED: POU domain, ( 723)  334 63.6 1.5e-09
XP_016882374 (OMIM: 164176) PREDICTED: POU domain, ( 723)  334 63.6 1.5e-09
NP_001234923 (OMIM: 164176) POU domain, class 2, t ( 400)  325 61.9 2.7e-09
NP_002689 (OMIM: 164176) POU domain, class 2, tran ( 463)  325 62.0   3e-09
XP_011525344 (OMIM: 164176) PREDICTED: POU domain, ( 485)  325 62.0 3.1e-09
XP_005259067 (OMIM: 164176) PREDICTED: POU domain, ( 586)  325 62.1 3.5e-09
XP_016882382 (OMIM: 164176) PREDICTED: POU domain, ( 608)  325 62.1 3.6e-09


>>NP_002691 (OMIM: 602459,602460) POU domain, class 4, t  (338 aa)
 initn: 2257 init1: 2257 opt: 2257  Z-score: 1901.9  bits: 360.3 E(85289): 3.4e-99
Smith-Waterman score: 2257; 100.0% identity (100.0% similar) in 338 aa overlap (1-338:1-338)

               10        20        30        40        50        60
pF1KB8 MMAMNSKQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MMAMNSKQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEAL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 AAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQGLEGDLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQGLEGDLL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 EHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMSHPHTVAPHSAMPACLSDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMSHPHTVAPHSAMPACLSDV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 ESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFESLTLSHNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFESLTLSHNN
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 MIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPS
              250       260       270       280       290       300

              310       320       330        
pF1KB8 SEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH
       ::::::::::::::::::::::::::::::::::::::
NP_002 SEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH
              310       320       330        

>>NP_004566 (OMIM: 113725) POU domain, class 4, transcri  (409 aa)
 initn: 1377 init1: 979 opt: 1208  Z-score: 1025.0  bits: 198.3 E(85289): 2.4e-50
Smith-Waterman score: 1506; 70.7% identity (86.3% similar) in 335 aa overlap (22-336:78-407)

                        10        20        30        40        50 
pF1KB8          MMAMNSKQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDE
                                     ::  .:::::::.:::.:   .::::..::
NP_004 SSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPP--SNIFGGLDE
        50        60        70        80        90         100     

              60        70                80        90         100 
pF1KB8 SLLARAEALAAVDIVSHGKNH--------PFKPDATYHTMSSVPCTS--TSSTVPISHPA
       ::::::::::::::::..:.:        :::::::::::...::::  .::.::::::.
NP_004 SLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPS
         110       120       130       140       150       160     

                      110       120       130       140       150  
pF1KB8 ALTS---------HPHHAVHQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAM
       ::..         : ::  ::.:::.::::.:: :.......:. .:. .  :  :...:
NP_004 ALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATM
         170       180       190       200       210       220     

             160       170       180       190       200       210 
pF1KB8 GHLHQA-MGMSHPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAA
       . .::: ..:.: : .  : .   :.:::..:::.:::::::::::::::::::::::.:
NP_004 NPMHQAALSMAHAHGLPSHMG---CMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSA
         230       240          250       260       270       280  

             220       230       240       250       260       270 
pF1KB8 LANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNG
       :::::::::::::::::::::::::::::::::::.::::::::: ..::: .:::::::
NP_004 LANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNG
            290       300       310       320       330       340  

             280       290       300       310       320       330 
pF1KB8 SERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKR
       .:.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKR
            350       360       370       380       390       400  

              
pF1KB8 MKYSAVH
       :::::  
NP_004 MKYSAGI
              

>>NP_006228 (OMIM: 601632) POU domain, class 4, transcri  (419 aa)
 initn: 1451 init1: 945 opt: 996  Z-score: 847.9  bits: 165.6 E(85289): 1.7e-40
Smith-Waterman score: 1223; 59.6% identity (69.4% similar) in 376 aa overlap (49-338:50-419)

       20        30        40        50        60         70       
pF1KB8 PKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEALAAVDI-VSHGKNHPFKPD
                                     .::.::::::::::::: ::.::.::::::
NP_006 HKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARAEALAAVDIAVSQGKSHPFKPD
      20        30        40        50        60        70         

        80        90       100       110        120                
pF1KB8 ATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQGLE-GDLLEHIS-PTLSV------
       ::::::.:::::::: :::..:      : ::  ::.:: ::::.::: :.:..      
NP_006 ATYHTMNSVPCTSTS-TVPLAH-----HHHHHHHHQALEPGDLLDHISSPSLALMAGAGG
      80        90        100            110       120       130   

                                            130       140          
pF1KB8 ---------------------------------------SGLGAPEHSVMPAQIHPH-HL
                                              .: :.:  ... .. ::: :.
NP_006 AGAAAGGGGAHDGPGGGGGPGGGGGPGGGPGGGGGGGPGGGGGGPGGGLLGGSAHPHPHM
           140       150       160       170       180       190   

     150                160          170                           
pF1KB8 GAMGHL-HQAM--------GMSHPHTVAP---HSAMPAC---------------------
        ..::: : :         :. ::  ::    :.:  :                      
NP_006 HSLGHLSHPAAAAAMNMPSGLPHPGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAA
           200       210       220       230       240       250   

            180       190       200       210       220       230  
pF1KB8 ----LSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFE
           . : ..:::::::::::::::::::::::::::.::::::::::::::::::::::
NP_006 GLASICDSDTDPRELEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFE
           260       270       280       290       300       310   

            240       250       260       270       280       290  
pF1KB8 SLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAY
       ::::::::::::::.:::::::::.: ::: .:::::::.:.::::::::::::::::::
NP_006 SLTLSHNNMIALKPILQAWLEEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAY
           320       330       340       350       360       370   

            300       310       320       330        
pF1KB8 FAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH
       ::.::::::::::::::::::::::::::::::::::::::.::..
NP_006 FAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKFSATY
           380       390       400       410         

>--
 initn: 215 init1: 172 opt: 225  Z-score: 204.1  bits: 46.5 E(85289): 0.00012
Smith-Waterman score: 225; 67.3% identity (89.8% similar) in 49 aa overlap (1-48:1-49)

                10        20        30        40        50         
pF1KB8 MMAMNSKQP-FGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEA
       ::.:::::: :.:::.: : :. ::::.:::.::.:::.: ::.:.:.:           
NP_006 MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARAEA
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB8 LAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQGLEGDL
                                                                   
NP_006 LAAVDIAVSQGKSHPFKPDATYHTMNSVPCTSTSTVPLAHHHHHHHHHQALEPGDLLDHI
               70        80        90       100       110       120

>>NP_005595 (OMIM: 600494) POU domain, class 3, transcri  (443 aa)
 initn: 535 init1: 364 opt: 522  Z-score: 451.8  bits: 92.4 E(85289): 2e-18
Smith-Waterman score: 537; 43.2% identity (66.9% similar) in 236 aa overlap (117-332:186-412)

         90       100       110       120       130                
pF1KB8 PCTSTSSTVPISHPAALTSHPHHAVHQGLEGDLLEHISPTLSVSGL----GAP----EHS
                                     : :: . .:...:.:.    : :    .:.
NP_005 HHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLL-YSQPSFTVNGMLGAGGQPAGLHHHG
         160       170       180        190       200       210    

      140       150       160       170              180           
pF1KB8 VMPAQIHPHHLGAMGHLHQAMGMSHPHTVAPHS-------AMPACLSDVESD---PR--E
       .  :. .:::     : :     ::::   :         . :.   : .::   :   .
NP_005 LRDAHDEPHHADHHPHPH-----SHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDD
          220       230            240       250       260         

        190       200       210       220       230       240      
pF1KB8 LEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKP
       :: ::..::::::::: :::::: ::..:   : . .::.::::::.: :: .::  :::
NP_005 LEQFAKQFKQRRIKLGFTQADVGLALGTLY--G-NVFSQTTICRFEALQLSFKNMCKLKP
     270       280       290         300        310       320      

        250       260       270       280       290       300      
pF1KB8 VLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAA
       .:. :::::...    .:  ..   .....::::: .  : .::..:   :.::...:..
NP_005 LLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITS
        330       340       350       360       370       380      

        310       320       330                                 
pF1KB8 IAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH                         
       .:..:.:.:.::::::::.:::.:::                               
NP_005 LADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ
        390       400       410       420       430       440   

>>NP_006227 (OMIM: 602480) POU domain, class 3, transcri  (500 aa)
 initn: 542 init1: 362 opt: 512  Z-score: 442.8  bits: 90.9 E(85289): 6.3e-18
Smith-Waterman score: 540; 37.0% identity (61.0% similar) in 305 aa overlap (37-332:176-464)

         10        20        30        40          50        60    
pF1KB8 KQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNI--FGSFDESLLARAEALAAVD
                                     : :  ::.   .:.   .  : : : ::. 
NP_006 GPDVKGGAGRDDLHAGTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAH
         150       160       170       180       190       200     

           70        80           90       100       110        120
pF1KB8 IVSHGKNHPFKPDATYHTMS---SVPCTSTSSTVPISHPAALTSHPHHAVHQGL-EGDLL
       . : . ..   :..  ...    .:    ..   : .  ..  .  .  :: :: .::  
NP_006 LPSMAGGQQPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGD--
         210       220       230       240       250       260     

              130       140       150       160         170        
pF1KB8 EHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMSHP--HTVAPHSAMPACLS
          .: :.       .: . :   ::::  .  :   . : . :  ..  :::   .  :
NP_006 ---TPELAEHH-HHHHHHAHPHPPHPHHAQGPPHHGGGGGGAGPGLNSHDPHSDEDTPTS
              270        280       290       300       310         

      180       190       200       210       220        230       
pF1KB8 DVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSL-SQSTICRFESLTLS
       :      .:: ::..::::::::: :::::: ::..:     :.. ::.::::::.: ::
NP_006 D------DLEQFAKQFKQRRIKLGFTQADVGLALGTL----YGNVFSQTTICRFEALQLS
     320             330       340       350           360         

       240       250       260       270       280       290       
pF1KB8 HNNMIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQP
        .::  :::.:. :::::...    .:  ..   .....::::: .  : .::..:   :
NP_006 FKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCP
     370       380       390       400       410       420         

       300       310       320       330                           
pF1KB8 RPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH                   
       .::...:. .:..:.:.:.::::::::.:::.:::                         
NP_006 KPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQVGTVSADTP
     430       440       450       460       470       480         

NP_006 PPHHGLQTSVQ
     490       500

>>NP_002690 (OMIM: 602479) POU domain, class 3, transcri  (451 aa)
 initn: 550 init1: 352 opt: 508  Z-score: 440.0  bits: 90.2 E(85289): 9e-18
Smith-Waterman score: 523; 44.0% identity (67.1% similar) in 234 aa overlap (108-336:188-401)

        80        90       100       110        120       130      
pF1KB8 ATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQ-GLEGDLLEHISPTLSVSGLGAPE
                                     :::.:. : :..:     : :     ::  
NP_002 LYAQAAYPGGGGGGLAGMLAAGGGGAGPGLHHALHEDGHEAQLEPSPPPHL-----GAHG
       160       170       180       190       200            210  

        140       150          160       170       180       190   
pF1KB8 HSVMPAQIHPHHLG---AMGHLHQAMGMSHPHTVAPHSAMPACLSDVESDPRELEAFAER
       :    :. : :  :   : .::: . : .   .:. ::   :  ::      .:: ::..
NP_002 H----AHGHAHAGGLHAAAAHLHPGAG-GGGSSVGEHSDEDAPSSD------DLEQFAKQ
                220       230        240       250             260 

           200       210       220        230       240       250  
pF1KB8 FKQRRIKLGVTQADVGAALANLKIPGVGSL-SQSTICRFESLTLSHNNMIALKPVLQAWL
       ::::::::: :::::: ::..:     :.. ::.::::::.: :: .::  :::.:. ::
NP_002 FKQRRIKLGFTQADVGLALGTL----YGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWL
             270       280           290       300       310       

            260       270       280       290       300       310  
pF1KB8 EEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLD
       ::....    ..  ..   .....::::: .  : .::..:   :.::...:...:..:.
NP_002 EETDSSSGSPTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLKCPKPSAHEITGLADSLQ
       320       330       340       350       360       370       

            320       330                                          
pF1KB8 LKKNVVRVWFCNQRQKQKRMKYSAVH                                  
       :.:.::::::::.:::.:::  .:                                    
NP_002 LEKEVVRVWFCNRRQKEKRMTPAAGAGHPPMDDVYAPGELGPGGGGASPPSAPPPPPPAA
       380       390       400       410       420       430       

>>NP_000298 (OMIM: 300039,304400) POU domain, class 3, t  (361 aa)
 initn: 519 init1: 357 opt: 496  Z-score: 431.2  bits: 88.3 E(85289): 2.8e-17
Smith-Waterman score: 511; 39.2% identity (62.7% similar) in 268 aa overlap (66-332:101-336)

          40        50        60        70        80        90     
pF1KB8 LPAPQLQGNIFGSFDESLLARAEALAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTV
                                     :.: . :  .:.:     : .:  : .:. 
NP_000 LATSPLDQQDVKPGREDLQLGAIIHHRSPHVAHHSPHTNHPNAW--GASPAPNPSITSS-
               80        90       100       110         120        

         100       110       120       130       140       150     
pF1KB8 PISHPAALTSHPHHAVHQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHL
         ..:  . :.:  .:     . .::: .  :.    .:  .:. :.  .:   : .:  
NP_000 --GQPLNVYSQPGFTV-----SGMLEHGG--LTPPPAAASAQSLHPVLREPPDHGELGS-
         130       140              150       160       170        

         160       170       180       190       200       210     
pF1KB8 HQAMGMSHPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANL
                :    ::   .  ::      ::: ::..::::::::: :::::: ::..:
NP_000 ---------HHCQDHSDEETPTSD------ELEQFAKQFKQRRIKLGFTQADVGLALGTL
                180       190             200       210       220  

         220        230       240       250       260       270    
pF1KB8 KIPGVGSL-SQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNGSER
            :.. ::.::::::.: :: .::  :::.:. :::::...    .:  ..   ...
NP_000 ----YGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRK
                230       240       250       260       270        

          280       290       300       310       320       330    
pF1KB8 KRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKY
       ..::::: .  :  ::..:   :.:....:...:..:.:.:.::::::::.:::.:::  
NP_000 RKKRTSIEVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTP
      280       290       300       310       320       330        

                              
pF1KB8 SAVH                   
                              
NP_000 PGDQQPHEVYSHTVKTDTSCHDL
      340       350       360 

>>XP_016872976 (OMIM: 607394) PREDICTED: POU domain, cla  (356 aa)
 initn: 489 init1: 216 opt: 492  Z-score: 427.9  bits: 87.6 E(85289): 4.3e-17
Smith-Waterman score: 500; 39.8% identity (62.8% similar) in 266 aa overlap (83-332:80-339)

             60        70        80        90           100        
pF1KB8 LLARAEALAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISH----PAALTSHPH
                                     ... :: . .:  :...    :. : :  .
XP_016 LSDSLQQTLSHRPCHLSQGPAMMSGNQMSGLNASPCQDMASLHPLQQLVLVPGHLQSVSQ
      50        60        70        80        90       100         

      110             120       130       140       150       160  
pF1KB8 HAV------HQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMS
         .      .:::. .::    :  . :::  :. .   :.    : :  :   .    .
XP_016 FLLSQTQPGQQGLQPNLLPF--PQQQ-SGLLLPQTGPGLASQAFGHPGLPGSSLEPHLEA
     110       120         130        140       150       160      

            170       180       190       200       210       220  
pF1KB8 HPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGS
         :  .:.    .  .:  :: .::: ::. ::::::::: ::.::: :..  :. : ..
XP_016 SQHLPVPKHLPSSGGADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-ND
        170       180       190       200       210         220    

            230       240       250       260            270       
pF1KB8 LSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKN-----SKPELFNGSERKRK
       .::.:: :::.:.:: .::  :::.:. ::..::..  . .     : : : .   ::::
XP_016 FSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRK
           230       240       250       260       270       280   

        280       290       300       310       320       330      
pF1KB8 -RTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSA
        :::: .  . .::  :  .:.::::.:. :::.:...:.::::::::.:::.::.    
XP_016 KRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPV
           290       300       310       320       330       340   

                    
pF1KB8 VH           
                    
XP_016 ATPIKPPVYNSRL
           350      

>>XP_011541044 (OMIM: 607394) PREDICTED: POU domain, cla  (403 aa)
 initn: 489 init1: 216 opt: 492  Z-score: 427.3  bits: 87.7 E(85289): 4.6e-17
Smith-Waterman score: 500; 39.8% identity (62.8% similar) in 266 aa overlap (83-332:47-306)

             60        70        80        90           100        
pF1KB8 LLARAEALAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISH----PAALTSHPH
                                     ... :: . .:  :...    :. : :  .
XP_011 LSDSLQQTLSHRPCHLSQGPAMMSGNQMSGLNASPCQDMASLHPLQQLVLVPGHLQSVSQ
         20        30        40        50        60        70      

      110             120       130       140       150       160  
pF1KB8 HAV------HQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMS
         .      .:::. .::    :  . :::  :. .   :.    : :  :   .    .
XP_011 FLLSQTQPGQQGLQPNLLPF--PQQQ-SGLLLPQTGPGLASQAFGHPGLPGSSLEPHLEA
         80        90         100        110       120       130   

            170       180       190       200       210       220  
pF1KB8 HPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGS
         :  .:.    .  .:  :: .::: ::. ::::::::: ::.::: :..  :. : ..
XP_011 SQHLPVPKHLPSSGGADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-ND
           140       150       160       170       180          190

            230       240       250       260            270       
pF1KB8 LSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKN-----SKPELFNGSERKRK
       .::.:: :::.:.:: .::  :::.:. ::..::..  . .     : : : .   ::::
XP_011 FSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRK
              200       210       220       230       240       250

        280       290       300       310       320       330      
pF1KB8 -RTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSA
        :::: .  . .::  :  .:.::::.:. :::.:...:.::::::::.:::.::.    
XP_011 KRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPV
              260       270       280       290       300       310

                                                                   
pF1KB8 VH                                                          
                                                                   
XP_011 ATPIKPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSP
              320       330       340       350       360       370

>>XP_011541045 (OMIM: 607394) PREDICTED: POU domain, cla  (403 aa)
 initn: 489 init1: 216 opt: 492  Z-score: 427.3  bits: 87.7 E(85289): 4.6e-17
Smith-Waterman score: 500; 39.8% identity (62.8% similar) in 266 aa overlap (83-332:47-306)

             60        70        80        90           100        
pF1KB8 LLARAEALAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISH----PAALTSHPH
                                     ... :: . .:  :...    :. : :  .
XP_011 LSDSLQQTLSHRPCHLSQGPAMMSGNQMSGLNASPCQDMASLHPLQQLVLVPGHLQSVSQ
         20        30        40        50        60        70      

      110             120       130       140       150       160  
pF1KB8 HAV------HQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMS
         .      .:::. .::    :  . :::  :. .   :.    : :  :   .    .
XP_011 FLLSQTQPGQQGLQPNLLPF--PQQQ-SGLLLPQTGPGLASQAFGHPGLPGSSLEPHLEA
         80        90         100        110       120       130   

            170       180       190       200       210       220  
pF1KB8 HPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGS
         :  .:.    .  .:  :: .::: ::. ::::::::: ::.::: :..  :. : ..
XP_011 SQHLPVPKHLPSSGGADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-ND
           140       150       160       170       180          190

            230       240       250       260            270       
pF1KB8 LSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKN-----SKPELFNGSERKRK
       .::.:: :::.:.:: .::  :::.:. ::..::..  . .     : : : .   ::::
XP_011 FSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRK
              200       210       220       230       240       250

        280       290       300       310       320       330      
pF1KB8 -RTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSA
        :::: .  . .::  :  .:.::::.:. :::.:...:.::::::::.:::.::.    
XP_011 KRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPV
              260       270       280       290       300       310

                                                                   
pF1KB8 VH                                                          
                                                                   
XP_011 ATPIKPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSP
              320       330       340       350       360       370




338 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 16:41:27 2016 done: Fri Nov  4 16:41:28 2016
 Total Scan time:  8.190 Total Display time:  0.030

Function used was FASTA [36.3.4 Apr, 2011]
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