Result of FASTA (omim) for pF1KB8363
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8363, 503 aa
  1>>>pF1KB8363 503 - 503 aa - 503 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.1007+/-0.000444; mu= 19.2995+/- 0.027
 mean_var=68.1099+/-14.460, 0's: 0 Z-trim(109.7): 150  B-trim: 1059 in 1/48
 Lambda= 0.155406
 statistics sampled from 17776 (17950) to 17776 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.557), E-opt: 0.2 (0.21), width:  16
 Scan time:  8.070

The best scores are:                                      opt bits E(85289)
NP_112503 (OMIM: 107910,139300,613546) aromatase [ ( 503) 3319 753.7 2.8e-217
NP_000094 (OMIM: 107910,139300,613546) aromatase [ ( 503) 3319 753.7 2.8e-217
XP_005254248 (OMIM: 107910,139300,613546) PREDICTE ( 503) 3319 753.7 2.8e-217
XP_016883180 (OMIM: 126065,143880) PREDICTED: 1,25 ( 514)  348 87.6 9.3e-17
XP_005260361 (OMIM: 126065,143880) PREDICTED: 1,25 ( 514)  348 87.6 9.3e-17
XP_016883181 (OMIM: 126065,143880) PREDICTED: 1,25 ( 514)  348 87.6 9.3e-17
NP_000773 (OMIM: 126065,143880) 1,25-dihydroxyvita ( 514)  348 87.6 9.3e-17
XP_016863526 (OMIM: 210370,608614) PREDICTED: cyto ( 393)  335 84.6 5.7e-16
NP_997235 (OMIM: 210370,608614) cytochrome P450 4V ( 525)  335 84.7 7.1e-16
XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524)  325 82.5 3.4e-15
XP_011534666 (OMIM: 604087) PREDICTED: cholesterol ( 490)  321 81.6 5.9e-15
XP_016876422 (OMIM: 604087) PREDICTED: cholesterol ( 462)  307 78.4   5e-14
NP_006659 (OMIM: 604087) cholesterol 24-hydroxylas ( 500)  307 78.4 5.3e-14
NP_001265850 (OMIM: 606534) cytochrome P450 3A43 i ( 393)  303 77.4 8.2e-14
NP_476436 (OMIM: 606534) cytochrome P450 3A43 isof ( 503)  303 77.5 9.9e-14
XP_016868034 (OMIM: 606534) PREDICTED: cytochrome  ( 360)  293 75.2 3.6e-13
XP_016868033 (OMIM: 606534) PREDICTED: cytochrome  ( 360)  293 75.2 3.6e-13
XP_016868031 (OMIM: 606534) PREDICTED: cytochrome  ( 394)  293 75.2 3.9e-13
XP_016868032 (OMIM: 606534) PREDICTED: cytochrome  ( 394)  293 75.2 3.9e-13
NP_073731 (OMIM: 606534) cytochrome P450 3A43 isof ( 504)  293 75.3 4.7e-13
NP_001139624 (OMIM: 601637) lanosterol 14-alpha de ( 404)  289 74.3 7.4e-13
XP_011534667 (OMIM: 604087) PREDICTED: cholesterol ( 347)  286 73.6   1e-12
XP_005267331 (OMIM: 604087) PREDICTED: cholesterol ( 355)  286 73.6 1.1e-12
NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503)  286 73.7 1.4e-12
NP_000764 (OMIM: 124040) cytochrome P450 2E1 precu ( 493)  285 73.5 1.6e-12
NP_085079 (OMIM: 608054) cytochrome P450 2A7 isofo ( 443)  283 73.0   2e-12
NP_001185783 (OMIM: 601129) cytochrome P450 2C8 is ( 388)  282 72.7 2.1e-12
NP_000755 (OMIM: 608054) cytochrome P450 2A7 isofo ( 494)  283 73.0 2.2e-12
NP_001185784 (OMIM: 601129) cytochrome P450 2C8 is ( 420)  282 72.8 2.3e-12
NP_001185782 (OMIM: 601129) cytochrome P450 2C8 is ( 420)  282 72.8 2.3e-12
NP_000761 (OMIM: 601129) cytochrome P450 2C8 isofo ( 490)  282 72.8 2.5e-12
NP_898898 (OMIM: 610670,615030) cytochrome P450 2U ( 544)  281 72.6 3.2e-12
XP_005262774 (OMIM: 610670,615030) PREDICTED: cyto ( 562)  281 72.6 3.3e-12
XP_016872682 (OMIM: 600081,608713) PREDICTED: vita ( 386)  279 72.1 3.4e-12
XP_016872683 (OMIM: 600081,608713) PREDICTED: vita ( 386)  279 72.1 3.4e-12
XP_011518197 (OMIM: 600081,608713) PREDICTED: vita ( 386)  279 72.1 3.4e-12
XP_011518200 (OMIM: 600081,608713) PREDICTED: vita ( 386)  279 72.1 3.4e-12
XP_016872680 (OMIM: 600081,608713) PREDICTED: vita ( 386)  279 72.1 3.4e-12
XP_016872681 (OMIM: 600081,608713) PREDICTED: vita ( 386)  279 72.1 3.4e-12
XP_016872684 (OMIM: 600081,608713) PREDICTED: vita ( 386)  279 72.1 3.4e-12
XP_016867271 (OMIM: 145500,605325) PREDICTED: cyto ( 322)  278 71.8 3.4e-12
NP_001189784 (OMIM: 124010) cytochrome P450 3A4 is ( 502)  280 72.4 3.5e-12
NP_059488 (OMIM: 124010) cytochrome P450 3A4 isofo ( 503)  280 72.4 3.5e-12
XP_016872679 (OMIM: 600081,608713) PREDICTED: vita ( 446)  279 72.1 3.8e-12
XP_005252846 (OMIM: 600081,608713) PREDICTED: vita ( 447)  279 72.1 3.8e-12
XP_005252845 (OMIM: 600081,608713) PREDICTED: vita ( 453)  279 72.1 3.8e-12
XP_016867270 (OMIM: 145500,605325) PREDICTED: cyto ( 389)  278 71.8 3.9e-12
XP_011514145 (OMIM: 145500,605325) PREDICTED: cyto ( 389)  278 71.8 3.9e-12
NP_001278758 (OMIM: 145500,605325) cytochrome P450 ( 389)  278 71.8 3.9e-12
NP_078790 (OMIM: 600081,608713) vitamin D 25-hydro ( 501)  279 72.1 4.1e-12


>>NP_112503 (OMIM: 107910,139300,613546) aromatase [Homo  (503 aa)
 initn: 3319 init1: 3319 opt: 3319  Z-score: 4022.0  bits: 753.7 E(85289): 2.8e-217
Smith-Waterman score: 3319; 99.4% identity (99.4% similar) in 503 aa overlap (1-503:1-503)

               10        20        30        40        50        60
pF1KB8 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEGTLIISKSSSMFHIMKHNHYSSRFGSKL
       :::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::
NP_112 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 ESGYVDVLTLLRRVMLDTSNTLFLRISLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
       :::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_112 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB8 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDSSLH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_112 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
              430       440       450       460       470       480

              490       500   
pF1KB8 PDETKNMLEMIFTPRNSDRCLEH
       :::::::::::::::::::::::
NP_112 PDETKNMLEMIFTPRNSDRCLEH
              490       500   

>>NP_000094 (OMIM: 107910,139300,613546) aromatase [Homo  (503 aa)
 initn: 3319 init1: 3319 opt: 3319  Z-score: 4022.0  bits: 753.7 E(85289): 2.8e-217
Smith-Waterman score: 3319; 99.4% identity (99.4% similar) in 503 aa overlap (1-503:1-503)

               10        20        30        40        50        60
pF1KB8 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEGTLIISKSSSMFHIMKHNHYSSRFGSKL
       :::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::
NP_000 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 ESGYVDVLTLLRRVMLDTSNTLFLRISLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
       :::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_000 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB8 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDSSLH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_000 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
              430       440       450       460       470       480

              490       500   
pF1KB8 PDETKNMLEMIFTPRNSDRCLEH
       :::::::::::::::::::::::
NP_000 PDETKNMLEMIFTPRNSDRCLEH
              490       500   

>>XP_005254248 (OMIM: 107910,139300,613546) PREDICTED: a  (503 aa)
 initn: 3319 init1: 3319 opt: 3319  Z-score: 4022.0  bits: 753.7 E(85289): 2.8e-217
Smith-Waterman score: 3319; 99.4% identity (99.4% similar) in 503 aa overlap (1-503:1-503)

               10        20        30        40        50        60
pF1KB8 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEGTLIISKSSSMFHIMKHNHYSSRFGSKL
       :::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::
XP_005 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 ESGYVDVLTLLRRVMLDTSNTLFLRISLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
       :::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_005 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB8 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDSSLH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
XP_005 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
              430       440       450       460       470       480

              490       500   
pF1KB8 PDETKNMLEMIFTPRNSDRCLEH
       :::::::::::::::::::::::
XP_005 PDETKNMLEMIFTPRNSDRCLEH
              490       500   

>>XP_016883180 (OMIM: 126065,143880) PREDICTED: 1,25-dih  (514 aa)
 initn: 258 init1:  98 opt: 348  Z-score: 421.9  bits: 87.6 E(85289): 9.3e-17
Smith-Waterman score: 364; 21.2% identity (56.9% similar) in 480 aa overlap (42-495:53-514)

              20        30        40        50        60        70 
pF1KB8 NITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIG
                                     ......:::     .: :.   ..:: : :
XP_016 QPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLL---QILWKG-G
             30        40        50        60        70            

                   80        90       100        110       120     
pF1KB8 SACNY-----YNRVYGEFMRVWISGEGTLIISKSSSMFHIMK-HNHYSSRFGSKLGLQCI
          ..     :.. ::...:. ...  .. ...   .  ... .. : .:.  :      
XP_016 LKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYR
       80        90       100       110       120       130        

         130        140       150        160       170       180   
pF1KB8 GMHEKGI-IFNNNPELWKTTRPFFMKALSGPGLV-RMVTVCAESLKTHLDRLEEVTNESG
        ....:  ..  . : :. .:  :.: :  :: : .. .   : :   . :..:. .: :
XP_016 DYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERG
      140       150       160       170       180       190        

            190               200       210        220       230   
pF1KB8 YV-DVLTLLRR--------VMLDTSNTLFLRISLDESA-IVVKIQGYFDAWQALLIKPDI
       .: :. . : .        :. .    :. . . ::.. ... :. .....  ... :  
XP_016 HVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVE
      200       210       220       230       240       250        

             240       250       260       270       280       290 
pF1KB8 FFKI--SWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL
       . :   . ... .  .   .  .... : .. .. : . .     ::  . :  ..:  :
XP_016 LHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPS----ADFLCD-IYHQNR--L
      260       270       280       290           300        310   

             300       310       320       330       340        350
pF1KB8 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDI-KIDDI
       .....   . :. .:: .: . ::...:. ....:.:.. ..::::.:. : .. . .:.
XP_016 SKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDL
             320       330       340       350       360       370 

              360       370       380       390       400          
pF1KB8 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPK
       ...  ..  . ::::  : : .. :   .  :.  : . ::: ..::   .   :  :  
XP_016 RNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFED
             380       390       400       410       420       430 

     410           420       430       440       450       460     
pF1KB8 PNEFT----LENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG
        ..:     :..  :  :. .. ::: : : : :. .: ....  :  ..:.. ... ..
XP_016 SSQFRPERWLQEKEKINPFAHL-PFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDN
             440       450        460       470       480       490

         470       480       490       500   
pF1KB8 QCVESIQKIHDSSLHPDETKNMLEMIFTPRNSDRCLEH
          : .. .:...: :..    : . :  :        
XP_016 ---EPVEMLHSGTLVPSRE---LPIAFCQR        
                 500          510            

>>XP_005260361 (OMIM: 126065,143880) PREDICTED: 1,25-dih  (514 aa)
 initn: 258 init1:  98 opt: 348  Z-score: 421.9  bits: 87.6 E(85289): 9.3e-17
Smith-Waterman score: 364; 21.2% identity (56.9% similar) in 480 aa overlap (42-495:53-514)

              20        30        40        50        60        70 
pF1KB8 NITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIG
                                     ......:::     .: :.   ..:: : :
XP_005 QPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLL---QILWKG-G
             30        40        50        60        70            

                   80        90       100        110       120     
pF1KB8 SACNY-----YNRVYGEFMRVWISGEGTLIISKSSSMFHIMK-HNHYSSRFGSKLGLQCI
          ..     :.. ::...:. ...  .. ...   .  ... .. : .:.  :      
XP_005 LKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYR
       80        90       100       110       120       130        

         130        140       150        160       170       180   
pF1KB8 GMHEKGI-IFNNNPELWKTTRPFFMKALSGPGLV-RMVTVCAESLKTHLDRLEEVTNESG
        ....:  ..  . : :. .:  :.: :  :: : .. .   : :   . :..:. .: :
XP_005 DYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERG
      140       150       160       170       180       190        

            190               200       210        220       230   
pF1KB8 YV-DVLTLLRR--------VMLDTSNTLFLRISLDESA-IVVKIQGYFDAWQALLIKPDI
       .: :. . : .        :. .    :. . . ::.. ... :. .....  ... :  
XP_005 HVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVE
      200       210       220       230       240       250        

             240       250       260       270       280       290 
pF1KB8 FFKI--SWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL
       . :   . ... .  .   .  .... : .. .. : . .     ::  . :  ..:  :
XP_005 LHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPS----ADFLCD-IYHQNR--L
      260       270       280       290           300        310   

             300       310       320       330       340        350
pF1KB8 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDI-KIDDI
       .....   . :. .:: .: . ::...:. ....:.:.. ..::::.:. : .. . .:.
XP_005 SKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDL
             320       330       340       350       360       370 

              360       370       380       390       400          
pF1KB8 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPK
       ...  ..  . ::::  : : .. :   .  :.  : . ::: ..::   .   :  :  
XP_005 RNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFED
             380       390       400       410       420       430 

     410           420       430       440       450       460     
pF1KB8 PNEFT----LENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG
        ..:     :..  :  :. .. ::: : : : :. .: ....  :  ..:.. ... ..
XP_005 SSQFRPERWLQEKEKINPFAHL-PFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDN
             440       450        460       470       480       490

         470       480       490       500   
pF1KB8 QCVESIQKIHDSSLHPDETKNMLEMIFTPRNSDRCLEH
          : .. .:...: :..    : . :  :        
XP_005 ---EPVEMLHSGTLVPSRE---LPIAFCQR        
                 500          510            

>>XP_016883181 (OMIM: 126065,143880) PREDICTED: 1,25-dih  (514 aa)
 initn: 258 init1:  98 opt: 348  Z-score: 421.9  bits: 87.6 E(85289): 9.3e-17
Smith-Waterman score: 364; 21.2% identity (56.9% similar) in 480 aa overlap (42-495:53-514)

              20        30        40        50        60        70 
pF1KB8 NITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIG
                                     ......:::     .: :.   ..:: : :
XP_016 QPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLL---QILWKG-G
             30        40        50        60        70            

                   80        90       100        110       120     
pF1KB8 SACNY-----YNRVYGEFMRVWISGEGTLIISKSSSMFHIMK-HNHYSSRFGSKLGLQCI
          ..     :.. ::...:. ...  .. ...   .  ... .. : .:.  :      
XP_016 LKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYR
       80        90       100       110       120       130        

         130        140       150        160       170       180   
pF1KB8 GMHEKGI-IFNNNPELWKTTRPFFMKALSGPGLV-RMVTVCAESLKTHLDRLEEVTNESG
        ....:  ..  . : :. .:  :.: :  :: : .. .   : :   . :..:. .: :
XP_016 DYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERG
      140       150       160       170       180       190        

            190               200       210        220       230   
pF1KB8 YV-DVLTLLRR--------VMLDTSNTLFLRISLDESA-IVVKIQGYFDAWQALLIKPDI
       .: :. . : .        :. .    :. . . ::.. ... :. .....  ... :  
XP_016 HVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVE
      200       210       220       230       240       250        

             240       250       260       270       280       290 
pF1KB8 FFKI--SWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL
       . :   . ... .  .   .  .... : .. .. : . .     ::  . :  ..:  :
XP_016 LHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPS----ADFLCD-IYHQNR--L
      260       270       280       290           300        310   

             300       310       320       330       340        350
pF1KB8 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDI-KIDDI
       .....   . :. .:: .: . ::...:. ....:.:.. ..::::.:. : .. . .:.
XP_016 SKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDL
             320       330       340       350       360       370 

              360       370       380       390       400          
pF1KB8 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPK
       ...  ..  . ::::  : : .. :   .  :.  : . ::: ..::   .   :  :  
XP_016 RNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFED
             380       390       400       410       420       430 

     410           420       430       440       450       460     
pF1KB8 PNEFT----LENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG
        ..:     :..  :  :. .. ::: : : : :. .: ....  :  ..:.. ... ..
XP_016 SSQFRPERWLQEKEKINPFAHL-PFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDN
             440       450        460       470       480       490

         470       480       490       500   
pF1KB8 QCVESIQKIHDSSLHPDETKNMLEMIFTPRNSDRCLEH
          : .. .:...: :..    : . :  :        
XP_016 ---EPVEMLHSGTLVPSRE---LPIAFCQR        
                 500          510            

>>NP_000773 (OMIM: 126065,143880) 1,25-dihydroxyvitamin   (514 aa)
 initn: 258 init1:  98 opt: 348  Z-score: 421.9  bits: 87.6 E(85289): 9.3e-17
Smith-Waterman score: 364; 21.2% identity (56.9% similar) in 480 aa overlap (42-495:53-514)

              20        30        40        50        60        70 
pF1KB8 NITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIG
                                     ......:::     .: :.   ..:: : :
NP_000 QPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLL---QILWKG-G
             30        40        50        60        70            

                   80        90       100        110       120     
pF1KB8 SACNY-----YNRVYGEFMRVWISGEGTLIISKSSSMFHIMK-HNHYSSRFGSKLGLQCI
          ..     :.. ::...:. ...  .. ...   .  ... .. : .:.  :      
NP_000 LKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYR
       80        90       100       110       120       130        

         130        140       150        160       170       180   
pF1KB8 GMHEKGI-IFNNNPELWKTTRPFFMKALSGPGLV-RMVTVCAESLKTHLDRLEEVTNESG
        ....:  ..  . : :. .:  :.: :  :: : .. .   : :   . :..:. .: :
NP_000 DYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERG
      140       150       160       170       180       190        

            190               200       210        220       230   
pF1KB8 YV-DVLTLLRR--------VMLDTSNTLFLRISLDESA-IVVKIQGYFDAWQALLIKPDI
       .: :. . : .        :. .    :. . . ::.. ... :. .....  ... :  
NP_000 HVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVE
      200       210       220       230       240       250        

             240       250       260       270       280       290 
pF1KB8 FFKI--SWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL
       . :   . ... .  .   .  .... : .. .. : . .     ::  . :  ..:  :
NP_000 LHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPS----ADFLCD-IYHQNR--L
      260       270       280       290           300        310   

             300       310       320       330       340        350
pF1KB8 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDI-KIDDI
       .....   . :. .:: .: . ::...:. ....:.:.. ..::::.:. : .. . .:.
NP_000 SKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDL
             320       330       340       350       360       370 

              360       370       380       390       400          
pF1KB8 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPK
       ...  ..  . ::::  : : .. :   .  :.  : . ::: ..::   .   :  :  
NP_000 RNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFED
             380       390       400       410       420       430 

     410           420       430       440       450       460     
pF1KB8 PNEFT----LENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG
        ..:     :..  :  :. .. ::: : : : :. .: ....  :  ..:.. ... ..
NP_000 SSQFRPERWLQEKEKINPFAHL-PFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDN
             440       450        460       470       480       490

         470       480       490       500   
pF1KB8 QCVESIQKIHDSSLHPDETKNMLEMIFTPRNSDRCLEH
          : .. .:...: :..    : . :  :        
NP_000 ---EPVEMLHSGTLVPSRE---LPIAFCQR        
                 500          510            

>>XP_016863526 (OMIM: 210370,608614) PREDICTED: cytochro  (393 aa)
 initn: 199 init1: 105 opt: 335  Z-score: 407.8  bits: 84.6 E(85289): 5.7e-16
Smith-Waterman score: 343; 29.0% identity (62.4% similar) in 255 aa overlap (233-464:114-362)

            210       220       230       240       250       260  
pF1KB8 FLRISLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEK
                                     ..:: .: .::   :.. :.   . .:::.
XP_016 DSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKK---SLQILHTFTNSVIAER
            90       100       110       120          130       140

            270                     280       290        300       
pF1KB8 RRRISTEE--------------KLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAA
         .....:              : .  .:.   : ... .:. :..:.. . .  ... .
XP_016 ANEMNANEDCRGDGRGSAPSKNKRRAFLDLL--LSVTDDEGNRLSHEDIREEVDTFMFEG
              150       160       170         180       190        

       310       320       330       340         350       360     
pF1KB8 PDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMR
        :: .... . :.:....:.:.. . .:.. :.:. :    ..:..::. .:  : :..:
XP_016 HDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLR
      200       210       220       230       240       250        

         370       380       390       400        410        420   
pF1KB8 YQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENF-AKNV-
         : : :  :.. ::  . :: : :::. ..    .::  ..::.:.::  : :  .:. 
XP_016 LFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQ
      260       270       280       290       300       310        

               430       440       450       460       470         
pF1KB8 ---PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDSSL
          :: :  ::. :::.: :. .:..  :.::  .::.: ... :               
XP_016 GRHPYAYV-PFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRP
      320        330       340       350       360       370       

     480       490       500   
pF1KB8 HPDETKNMLEMIFTPRNSDRCLEH
                               
XP_016 SNGIWIKLKRRNADER        
       380       390           

>>NP_997235 (OMIM: 210370,608614) cytochrome P450 4V2 [H  (525 aa)
 initn: 227 init1: 105 opt: 335  Z-score: 406.0  bits: 84.7 E(85289): 7.1e-16
Smith-Waterman score: 343; 29.0% identity (62.4% similar) in 255 aa overlap (233-464:246-494)

            210       220       230       240       250       260  
pF1KB8 FLRISLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEK
                                     ..:: .: .::   :.. :.   . .:::.
NP_997 DSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKK---SLQILHTFTNSVIAER
         220       230       240       250          260       270  

            270                     280       290        300       
pF1KB8 RRRISTEE--------------KLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAA
         .....:              : .  .:.   : ... .:. :..:.. . .  ... .
NP_997 ANEMNANEDCRGDGRGSAPSKNKRRAFLDLL--LSVTDDEGNRLSHEDIREEVDTFMFEG
            280       290       300         310       320       330

       310       320       330       340         350       360     
pF1KB8 PDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMR
        :: .... . :.:....:.:.. . .:.. :.:. :    ..:..::. .:  : :..:
NP_997 HDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLR
              340       350       360       370       380       390

         370       380       390       400        410        420   
pF1KB8 YQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENF-AKNV-
         : : :  :.. ::  . :: : :::. ..    .::  ..::.:.::  : :  .:. 
NP_997 LFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQ
              400       410       420       430       440       450

               430       440       450       460       470         
pF1KB8 ---PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDSSL
          :: :  ::. :::.: :. .:..  :.::  .::.: ... :               
NP_997 GRHPYAYV-PFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRP
               460       470       480       490       500         

     480       490       500   
pF1KB8 HPDETKNMLEMIFTPRNSDRCLEH
                               
NP_997 SNGIWIKLKRRNADER        
     510       520             

>>XP_005262992 (OMIM: 210370,608614) PREDICTED: cytochro  (524 aa)
 initn: 186 init1: 105 opt: 325  Z-score: 393.9  bits: 82.5 E(85289): 3.4e-15
Smith-Waterman score: 333; 29.0% identity (62.4% similar) in 255 aa overlap (233-464:246-493)

            210       220       230       240       250       260  
pF1KB8 FLRISLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEK
                                     ..:: .: .::   :.. :.   . .:::.
XP_005 DSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKK---SLQILHTFTNSVIAER
         220       230       240       250          260       270  

            270                     280       290        300       
pF1KB8 RRRISTEE--------------KLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAA
         .....:              : .  .:.   : ... .:. :..:.. . .  ... .
XP_005 ANEMNANEDCRGDGRGSAPSKNKRRAFLDLL--LSVTDDEGNRLSHEDIREEVDTFMFEG
            280       290       300         310       320       330

       310       320       330       340         350       360     
pF1KB8 PDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMR
        :: .... . :.:....:.:.. . .:.. :.:. :    ..:..::. .:  : :..:
XP_005 HDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLR
              340       350       360       370       380       390

         370       380       390       400        410        420   
pF1KB8 YQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENF-AKNV-
         : : :  :.. ::  . :: : :::. ..    .::  ..::.:.::  : :  .:. 
XP_005 LFPSVPLFARSVSEDCEV-GYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQ
              400        410       420       430       440         

               430       440       450       460       470         
pF1KB8 ---PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDSSL
          :: :  ::. :::.: :. .:..  :.::  .::.: ... :               
XP_005 GRHPYAYV-PFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRP
     450        460       470       480       490       500        

     480       490       500   
pF1KB8 HPDETKNMLEMIFTPRNSDRCLEH
                               
XP_005 SNGIWIKLKRRNADER        
      510       520            




503 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 12:15:17 2016 done: Fri Nov  4 12:15:19 2016
 Total Scan time:  8.070 Total Display time:  0.080

Function used was FASTA [36.3.4 Apr, 2011]
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