Result of FASTA (omim) for pF1KB8186
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8186, 303 aa
  1>>>pF1KB8186 303 - 303 aa - 303 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.3819+/-0.000348; mu= 15.4001+/- 0.022
 mean_var=74.5576+/-14.717, 0's: 0 Z-trim(115.2): 9  B-trim: 83 in 1/53
 Lambda= 0.148535
 statistics sampled from 25505 (25510) to 25505 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.299), width:  16
 Scan time:  6.400

The best scores are:                                      opt bits E(85289)
NP_001668 (OMIM: 145500,182330) sodium/potassium-t ( 303) 2095 458.1 9.8e-129
NP_001669 (OMIM: 182331) sodium/potassium-transpor ( 290)  512 118.9 1.2e-26
NP_000696 (OMIM: 137217) potassium-transporting AT ( 291)  389 92.5 1.1e-18
NP_001670 (OMIM: 601867) sodium/potassium-transpor ( 279)  317 77.1 4.5e-14
NP_001290192 (OMIM: 182331) sodium/potassium-trans ( 208)  257 64.1 2.7e-10


>>NP_001668 (OMIM: 145500,182330) sodium/potassium-trans  (303 aa)
 initn: 2095 init1: 2095 opt: 2095  Z-score: 2432.2  bits: 458.1 E(85289): 9.8e-129
Smith-Waterman score: 2095; 100.0% identity (100.0% similar) in 303 aa overlap (1-303:1-303)

               10        20        30        40        50        60
pF1KB8 MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIE
              250       260       270       280       290       300

          
pF1KB8 VKS
       :::
NP_001 VKS
          

>>NP_001669 (OMIM: 182331) sodium/potassium-transporting  (290 aa)
 initn: 661 init1: 347 opt: 512  Z-score: 599.2  bits: 118.9 E(85289): 1.2e-26
Smith-Waterman score: 729; 39.5% identity (67.4% similar) in 304 aa overlap (4-301:11-287)

                      10        20        30        40        50   
pF1KB8        MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGT
                 :.. ::  ::.:.:: . ..:.:::: ::  :::::..::: :...:  :
NP_001 MVIQKEKKSCGQVVEE--WKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLT
               10          20        30        40        50        

            60        70        80        90       100       110   
pF1KB8 IQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYK
       . ::: :.:.  : ::::.: :::   :. .. ..    .: .:.. .: .. .::: :.
NP_001 MWVMLQTVSDHTPKYQDRLATPGLMIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYN
       60        70        80        90       100       110        

             120         130       140       150       160         
pF1KB8 DS--AQRDDMIFEDC--GDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDET-YG
       ::  ::..:.    :  :    .: . : .:. .   ..:.:.   ::::::..: : ::
NP_001 DSIQAQKNDV----CRPGRYYEQP-DNGVLNYPK---RACQFNRTQLGNCSGIGDSTHYG
      120           130        140          150       160       170

      170       180       190       200       210       220        
pF1KB8 YKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVE
       :. :.::..::.:::..:      :.:..             : :.:::::: ...::  
NP_001 YSTGQPCVFIKMNRVINFYAG--ANQSMN-------------VTCAGKRDEDAENLGNFV
              180       190                      200       210     

      230       240       250       260       270       280        
pF1KB8 YFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYS-E
       .:  ...  . :.:.::::: .. .: :::.::.: :.: ..:. .::.  . ::. . :
NP_001 MFPANGN--IDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDE
         220         230       240       250       260       270   

       290       300    
pF1KB8 KDRFQGRFDVKIEVKS 
       .:.: ::   :...   
NP_001 RDKFAGRVAFKLRINKT
           280       290

>>NP_000696 (OMIM: 137217) potassium-transporting ATPase  (291 aa)
 initn: 477 init1: 194 opt: 389  Z-score: 456.7  bits: 92.5 E(85289): 1.1e-18
Smith-Waterman score: 522; 30.1% identity (61.8% similar) in 306 aa overlap (4-302:11-290)

                      10        20        30        40        50   
pF1KB8        MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGT
                 :.  ::  .... :: .  ..:::: . :  : :.:: ::  ..:.:   
NP_000 MAALQEKKTCGQRMEE--FQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALC
               10          20        30        40        50        

            60        70        80           90       100       110
pF1KB8 IQVMLLTISEFKPTYQDRVAPPGLTQIPQI---QKTEISFRPNDPKSYEAYVLNIVRFLE
       . :.. :.. . : :::..  ::.:  :..   .  :: .  .: ...   . ..  :: 
NP_000 LYVLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLA
       60        70        80        90       100       110        

              120       130       140       150       160       170
pF1KB8 KYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYK
        :. .::.:..   .: .     .:  .:      .  :.:  . : ::::: : ..:..
NP_000 GYSPAAQEDSI---NCTSEQYFFQE--SFRAPNHTKFSCKFTADMLQNCSGLADPNFGFE
      120          130       140         150       160       170   

              180       190       200       210       220          
pF1KB8 EGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGN---V
       :::::.:::.::.. : :.               : ..  :.:.   :. .. .:.   :
NP_000 EGKPCFIIKMNRIVKFLPS---------------NGSAPRVDCAFL-DQPRE-LGQPLQV
           180       190                      200         210      

       230       240       250       260       270       280       
pF1KB8 EYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSE
       .:.  ...  : :.:.:::::  ::.: .::.:... :.  ..:. : ::...:.. ...
NP_000 KYYPPNGT--FSLHYFPYYGKKAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNN
        220         230       240       250       260       270    

        290       300   
pF1KB8 -KDRFQGRFDVKIEVKS
        .: ..:. . :.... 
NP_000 PHDPYEGKVEFKLKIEK
          280       290 

>>NP_001670 (OMIM: 601867) sodium/potassium-transporting  (279 aa)
 initn: 580 init1: 241 opt: 317  Z-score: 373.6  bits: 77.1 E(85289): 4.5e-14
Smith-Waterman score: 603; 36.6% identity (60.4% similar) in 298 aa overlap (12-303:16-279)

                   10        20        30        40        50      
pF1KB8     MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQV
                      :: ::.:    ::::::. ::  :::::..::: ::..:  :. :
NP_001 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV
               10        20        30        40        50        60

         60        70        80         90       100       110     
pF1KB8 MLLTISEFKPTYQDRVAPPGLTQIPQ-IQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDS
       :: :...  : :.:..  :::  .:. .   : .:  .:: :: .:. .. .::. :   
NP_001 MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE
               70        80        90       100       110       120

         120       130       140        150       160       170    
pF1KB8 AQRDDMIFEDCGDVPSEPKERGDFNHERGERKV-CRFKLEWLGNCSGLNDETYGYKEGKP
        :..  .   : :        : . ...:   : :.: .  :  :::.::  .::..:.:
NP_001 EQKNLTV---CPD--------GALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNP
                 130               140       150       160         

          180       190       200       210       220       230    
pF1KB8 CIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGN
       ::..:.::..:.::        :  :          ..:..: .::  .:.   . :.  
NP_001 CILVKMNRIIGLKP--------EGVPR---------IDCVSK-NEDIPNVAVYPHNGM--
     170       180                        190        200           

          240       250       260       270         280         290
pF1KB8 SPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDT--EIRIECKAYGE-NI-GYSEKDR
          . :.:.::::: :.  :::::.::: .    .:  :. .:::  :  :. . ...:.
NP_001 ---IDLKYFPYYGKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDK
        210       220       230       240       250       260      

              300   
pF1KB8 FQGRFDVKIEVKS
       : ::   :: ...
NP_001 FLGRVMFKITARA
        270         

>>NP_001290192 (OMIM: 182331) sodium/potassium-transport  (208 aa)
 initn: 359 init1: 141 opt: 257  Z-score: 305.9  bits: 64.1 E(85289): 2.7e-10
Smith-Waterman score: 456; 35.8% identity (64.6% similar) in 226 aa overlap (81-301:4-205)

               60        70        80        90       100       110
pF1KB8 IGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLE
                                     :. .. ..    .: .:.. .: .. .:::
NP_001                            MIRPKTENLDVIVNVSDTESWDQHVQKLNKFLE
                                          10        20        30   

                120       130       140       150       160        
pF1KB8 KYKDS--AQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDET-Y
        :.::  ::..:.    :   :..  :. : .     ...:.:.   ::::::..: : :
NP_001 PYNDSIQAQKNDV----C--RPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHY
            40              50        60        70        80       

       170       180       190       200       210       220       
pF1KB8 GYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNV
       ::. :.::..::.:::..:      :.:..             : :.:::::: ...:: 
NP_001 GYSTGQPCVFIKMNRVINFYAGA--NQSMN-------------VTCAGKRDEDAENLGNF
        90       100       110                      120       130  

       230        240       250       260       270       280      
pF1KB8 EYFGL-GNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYS
        .:   ::   . :.:.::::: .. .: :::.::.: :.: ..:. .::.  . ::. .
NP_001 VMFPANGN---IDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATD
            140          150       160       170       180         

         290       300    
pF1KB8 -EKDRFQGRFDVKIEVKS 
        :.:.: ::   :...   
NP_001 DERDKFAGRVAFKLRINKT
     190       200        




303 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 10:19:28 2016 done: Fri Nov  4 10:19:29 2016
 Total Scan time:  6.400 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]
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