Result of FASTA (omim) for pF1KB8156
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8156, 404 aa
  1>>>pF1KB8156 404 - 404 aa - 404 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.8441+/-0.000402; mu= 16.1369+/- 0.025
 mean_var=105.6701+/-21.307, 0's: 0 Z-trim(113.6): 68  B-trim: 0 in 0/53
 Lambda= 0.124767
 statistics sampled from 22950 (23008) to 22950 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.638), E-opt: 0.2 (0.27), width:  16
 Scan time:  5.100

The best scores are:                                      opt bits E(85289)
NP_055241 (OMIM: 605937) sorting nexin-5 isoform a ( 404) 2600 478.8  1e-134
NP_689413 (OMIM: 605937) sorting nexin-5 isoform a ( 404) 2600 478.8  1e-134
NP_001269383 (OMIM: 605937) sorting nexin-5 isofor ( 299) 1903 353.2 4.7e-97
NP_689419 (OMIM: 606098) sorting nexin-6 isoform b ( 418) 1772 329.8 7.6e-90
XP_006720287 (OMIM: 606098) PREDICTED: sorting nex ( 381) 1409 264.4 3.3e-70
NP_067072 (OMIM: 606098) sorting nexin-6 isoform a ( 290) 1253 236.2 7.7e-62
NP_001265128 (OMIM: 605929) sorting nexin-2 isofor ( 402)  201 47.0 9.8e-05
NP_003091 (OMIM: 605929) sorting nexin-2 isoform 1 ( 519)  201 47.1 0.00012
XP_006710741 (OMIM: 614904) PREDICTED: sorting nex ( 387)  179 43.0  0.0015
XP_016856915 (OMIM: 614904) PREDICTED: sorting nex ( 387)  179 43.0  0.0015
XP_016856914 (OMIM: 614904) PREDICTED: sorting nex ( 387)  179 43.0  0.0015
XP_011539866 (OMIM: 614904) PREDICTED: sorting nex ( 387)  179 43.0  0.0015
XP_016856916 (OMIM: 614904) PREDICTED: sorting nex ( 387)  179 43.0  0.0015
NP_003090 (OMIM: 601272) sorting nexin-1 isoform a ( 522)  180 43.3  0.0016
NP_057060 (OMIM: 614904) sorting nexin-7 isoform a ( 451)  179 43.1  0.0017
NP_001229862 (OMIM: 601272) sorting nexin-1 isofor ( 557)  180 43.3  0.0017
XP_005254668 (OMIM: 601272) PREDICTED: sorting nex ( 399)  169 41.2  0.0053
NP_683758 (OMIM: 601272) sorting nexin-1 isoform b ( 457)  169 41.3  0.0059


>>NP_055241 (OMIM: 605937) sorting nexin-5 isoform a [Ho  (404 aa)
 initn: 2600 init1: 2600 opt: 2600  Z-score: 2539.7  bits: 478.8 E(85289): 1e-134
Smith-Waterman score: 2600; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:1-404)

               10        20        30        40        50        60
pF1KB8 MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 PEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 FAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 EMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 ADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYML
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 NIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEE
              310       320       330       340       350       360

              370       380       390       400    
pF1KB8 LINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN
       ::::::::::::::::::::::::::::::::::::::::::::
NP_055 LINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN
              370       380       390       400    

>>NP_689413 (OMIM: 605937) sorting nexin-5 isoform a [Ho  (404 aa)
 initn: 2600 init1: 2600 opt: 2600  Z-score: 2539.7  bits: 478.8 E(85289): 1e-134
Smith-Waterman score: 2600; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:1-404)

               10        20        30        40        50        60
pF1KB8 MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 PEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 PEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 FAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 FAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 EMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 EMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 ADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 ADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYML
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 NIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 NIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEE
              310       320       330       340       350       360

              370       380       390       400    
pF1KB8 LINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN
       ::::::::::::::::::::::::::::::::::::::::::::
NP_689 LINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN
              370       380       390       400    

>>NP_001269383 (OMIM: 605937) sorting nexin-5 isoform b   (299 aa)
 initn: 1903 init1: 1903 opt: 1903  Z-score: 1863.3  bits: 353.2 E(85289): 4.7e-97
Smith-Waterman score: 1903; 100.0% identity (100.0% similar) in 299 aa overlap (106-404:1-299)

          80        90       100       110       120       130     
pF1KB8 HDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAV
                                     ::::::::::::::::::::::::::::::
NP_001                               MQKLGEGEGSMTKEEFAKMKQELEAEYLAV
                                             10        20        30

         140       150       160       170       180       190     
pF1KB8 FKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSAD
               40        50        60        70        80        90

         200       210       220       230       240       250     
pF1KB8 EVLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLA
              100       110       120       130       140       150

         260       270       280       290       300       310     
pF1KB8 LEEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKA
              160       170       180       190       200       210

         320       330       340       350       360       370     
pF1KB8 LIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKN
              220       230       240       250       260       270

         380       390       400    
pF1KB8 LIEMSELEIKHARNNVSLLQSCIDLFKNN
       :::::::::::::::::::::::::::::
NP_001 LIEMSELEIKHARNNVSLLQSCIDLFKNN
              280       290         

>>NP_689419 (OMIM: 606098) sorting nexin-6 isoform b [Ho  (418 aa)
 initn: 1767 init1: 1739 opt: 1772  Z-score: 1734.0  bits: 329.8 E(85289): 7.6e-90
Smith-Waterman score: 1772; 64.5% identity (90.0% similar) in 400 aa overlap (5-404:21-417)

                               10        20        30        40    
pF1KB8                 MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDK
                           :..:  .::::. :....:::. : .::.:: ::::::::
NP_689 MRACAGPRLGAAMMEGLDDGPDFL--SEEDRG-LKAINVDLQSDAALQVDISDALSERDK
               10        20          30         40        50       

           50        60        70        80        90       100    
pF1KB8 VKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPRE
       ::::::::..::.:.. ::::.::::.:.::::...:. :::: :::::: .::::. ::
NP_689 VKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASRE
        60        70        80        90       100       110       

          110       120       130       140       150       160    
pF1KB8 KMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHV
       :.:::::::::::::::.::::::::::::.:::::. ::::: :...::.: .: ::::
NP_689 KLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHV
       120       130       140       150       160       170       

          170       180       190       200       210       220    
pF1KB8 FLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIK
       ::::.:::::: :: :: .  :::..::::: :. .:::.::::::.:..::..:.::.:
NP_689 FLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVK
       180       190       200       210       220       230       

          230       240       250       260       270       280    
pF1KB8 DSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVS
       :. .:.:.::::::..:::: . .. :..:. .. : : :..:::.:::.: ::.:.:::
NP_689 DASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVS
       240       250       260       270       280       290       

          290       300       310       320       330       340    
pF1KB8 SDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQ
       .::::::..::.::. . .:::::::::...:.::::.:::::::: :.:::  ::. ::
NP_689 ADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQ
       300       310       320       330       340       350       

          350       360       370       380       390       400    
pF1KB8 ECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN
        ::::::..:::::.:::.:: .:::::::::.:..:::.:::..:..:::.:. .....
NP_689 LCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGD
       360       370       380       390       400       410       

NP_689 T
        

>>XP_006720287 (OMIM: 606098) PREDICTED: sorting nexin-6  (381 aa)
 initn: 1561 init1: 1409 opt: 1409  Z-score: 1381.4  bits: 264.4 E(85289): 3.3e-70
Smith-Waterman score: 1510; 59.0% identity (81.5% similar) in 400 aa overlap (5-404:21-380)

                               10        20        30        40    
pF1KB8                 MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDK
                           :..:  .::::. :....:::. : .::.:: ::::::::
XP_006 MRACAGPRLGAAMMEGLDDGPDFL--SEEDRG-LKAINVDLQSDAALQVDISDALSERDK
               10        20          30         40        50       

           50        60        70        80        90       100    
pF1KB8 VKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPRE
       ::::::::                                     ::::: .::::. ::
XP_006 VKFTVHTK-------------------------------------IPPAPPRPDFDASRE
        60                                             70        80

          110       120       130       140       150       160    
pF1KB8 KMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHV
       :.:::::::::::::::.::::::::::::.:::::. ::::: :...::.: .: ::::
XP_006 KLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHV
               90       100       110       120       130       140

          170       180       190       200       210       220    
pF1KB8 FLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIK
       ::::.:::::: :: :: .  :::..::::: :. .:::.::::::.:..::..:.::.:
XP_006 FLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVK
              150       160       170       180       190       200

          230       240       250       260       270       280    
pF1KB8 DSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVS
       :. .:.:.::::::..:::: . .. :..:. .. : : :..:::.:::.: ::.:.:::
XP_006 DASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVS
              210       220       230       240       250       260

          290       300       310       320       330       340    
pF1KB8 SDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQ
       .::::::..::.::. . .:::::::::...:.::::.:::::::: :.:::  ::. ::
XP_006 ADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQ
              270       280       290       300       310       320

          350       360       370       380       390       400    
pF1KB8 ECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN
        ::::::..:::::.:::.:: .:::::::::.:..:::.:::..:..:::.:. .....
XP_006 LCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGD
              330       340       350       360       370       380

XP_006 T
        

>>NP_067072 (OMIM: 606098) sorting nexin-6 isoform a [Ho  (290 aa)
 initn: 1253 init1: 1253 opt: 1253  Z-score: 1231.2  bits: 236.2 E(85289): 7.7e-62
Smith-Waterman score: 1253; 63.7% identity (90.0% similar) in 289 aa overlap (116-404:1-289)

          90       100       110       120       130       140     
pF1KB8 AGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEV
                                     ::::::.::::::::::::.:::::. :::
NP_067                               MTKEEFTKMKQELEAEYLAIFKKTVAMHEV
                                             10        20        30

         150       160       170       180       190       200     
pF1KB8 FLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFTGVKEV
       :: :...::.: .: ::::::::.:::::: :: :: .  :::..::::: :. .:::.:
NP_067 FLCRVAAHPILRRDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDV
               40        50        60        70        80        90

         210       220       230       240       250       260     
pF1KB8 DDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKY
       :::::.:..::..:.::.::. .:.:.::::::..:::: . .. :..:. .. : : :.
NP_067 DDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKF
              100       110       120       130       140       150

         270       280       290       300       310       320     
pF1KB8 LLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKA
       .:::.:::.: ::.:.:::.::::::..::.::. . .:::::::::...:.::::.:::
NP_067 FLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKA
              160       170       180       190       200       210

         330       340       350       360       370       380     
pF1KB8 LDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIK
       ::::: :.:::  ::. :: ::::::..:::::.:::.:: .:::::::::.:..:::.:
NP_067 LDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELK
              220       230       240       250       260       270

         390       400     
pF1KB8 HARNNVSLLQSCIDLFKNN 
       ::..:..:::.:. ..... 
NP_067 HAKGNLQLLQNCLAVLNGDT
              280       290

>>NP_001265128 (OMIM: 605929) sorting nexin-2 isoform 2   (402 aa)
 initn: 236 init1: 149 opt: 201  Z-score: 206.0  bits: 47.0 E(85289): 9.8e-05
Smith-Waterman score: 360; 26.8% identity (57.6% similar) in 396 aa overlap (14-381:8-378)

               10        20         30        40            50     
pF1KB8 MAAVPELLQQQEEDRSKLRSVSVDLNVDP-SLQIDIPDALSERDKVK----FTVHTKTTL
                    :::. . .  . : :  ...: . :  .  : ..    . : :::.:
NP_001       MSAPVIFDRSR-EEIEEEANGDIFDIEIGVSDPEKVGDGMNAYMAYRVTTKTSL
                     10         20        30        40        50   

          60        70        80        90       100       110     
pF1KB8 PTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGS
         :.. :::: :.  ::. ::. :     ..: :.:::: : .. :    : :.  :. .
NP_001 SMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEK-SIVG----MTKVKVGKED
            60        70        80        90            100        

         120       130       140       150       160       170     
pF1KB8 MTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVR
        .. ::.. ..              .. : .:::  .::.: .: ... ::: ...:  :
NP_001 SSSTEFVEKRR--------------AALERYLQRTVKHPTLLQDPDLRQFLE-SSELP-R
      110                     120       130       140        150   

         180        190       200         210       220       230  
pF1KB8 RKNTKEMFG-GFFKSVVKSADEVLFTGVK--EVDDFFEQEKNFLINYYNRIKDSCVKADK
         ::. . : :... : :.:: :    .:  : : .::.... . :  ....   :... 
NP_001 AVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHVSVEA
            160       170       180       190       200       210  

            240       250           260       270       280        
pF1KB8 MTRSHKNVADDYIHTAACLHSLAL----EEPTVIKKYLLKVAELFEKLRKVEGRVSSDED
       ..  .:... .   :::  .: :.    :. :.... : ..::. ::. ... . .  . 
NP_001 LVCHRKELSAN---TAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADF
            220          230       240       250       260         

      290       300       310       320                       330  
pF1KB8 LKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKAL----------------DKARLK
         ..:::  :.  : :.: .. .: :    .:... .:                :: .  
NP_001 YMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQA
     270       280       290       300       310       320         

            340       350       360       370       380       390  
pF1KB8 SKDVKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVS
       .....  ::. :.  . :::.:.. ..:.  :...::  :.  .:.. :           
NP_001 KNEIREWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIK
     330       340       350       360       370       380         

            400     
pF1KB8 LLQSCIDLFKNN 
                    
NP_001 YWEAFLPEAKAIA
     390       400  

>>NP_003091 (OMIM: 605929) sorting nexin-2 isoform 1 [Ho  (519 aa)
 initn: 236 init1: 149 opt: 201  Z-score: 204.5  bits: 47.1 E(85289): 0.00012
Smith-Waterman score: 360; 26.8% identity (57.6% similar) in 396 aa overlap (14-381:125-495)

                                10        20         30        40  
pF1KB8                  MAAVPELLQQQEEDRSKLRSVSVDLNVDP-SLQIDIPDALSER
                                     :::. . .  . : :  ...: . :  .  
NP_003 EPSPAVTPVTPTTLIAPRIESKSMSAPVIFDRSR-EEIEEEANGDIFDIEIGVSDPEKVG
          100       110       120        130       140       150   

                 50        60        70        80        90        
pF1KB8 DKVK----FTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPD
       : ..    . : :::.:  :.. :::: :.  ::. ::. :     ..: :.:::: : .
NP_003 DGMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEK-S
           160       170       180       190       200       210   

      100       110       120       130       140       150        
pF1KB8 FDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSK
       . :    : :.  :. . .. ::.. ..              .. : .:::  .::.: .
NP_003 IVG----MTKVKVGKEDSSSTEFVEKRR--------------AALERYLQRTVKHPTLLQ
                220       230                     240       250    

      160       170       180        190       200         210     
pF1KB8 DRNFHVFLEYDQDLSVRRKNTKEMFG-GFFKSVVKSADEVLFTGVK--EVDDFFEQEKNF
       : ... ::: ...:  :  ::. . : :... : :.:: :    .:  : : .::.... 
NP_003 DPDLRQFLE-SSELP-RAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQ
          260         270       280       290       300       310  

         220       230       240       250           260       270 
pF1KB8 LINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLAL----EEPTVIKKYLLKVAE
       . :  ....   :... ..  .:... .   :::  .: :.    :. :.... : ..::
NP_003 FENLDQQLRKLHVSVEALVCHRKELSAN---TAAFAKSAAMLGNSEDHTALSRALSQLAE
            320       330       340          350       360         

             280       290       300       310       320           
pF1KB8 LFEKLRKVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKAL-----
       . ::. ... . .  .   ..:::  :.  : :.: .. .: :    .:... .:     
NP_003 VEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKRE
     370       380       390       400       410       420         

                   330       340       350       360       370     
pF1KB8 -----------DKARLKSKDVKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKN
                  :: .  .....  ::. :.  . :::.:.. ..:.  :...::  :.  
NP_003 AEAKMMVANKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTV
     430       440       450       460       470       480         

         380       390       400     
pF1KB8 LIEMSELEIKHARNNVSLLQSCIDLFKNN 
       .:.. :                        
NP_003 IIKYLESLVQTQQQLIKYWEAFLPEAKAIA
     490       500       510         

>>XP_006710741 (OMIM: 614904) PREDICTED: sorting nexin-7  (387 aa)
 initn: 213 init1:  95 opt: 179  Z-score: 184.8  bits: 43.0 E(85289): 0.0015
Smith-Waterman score: 219; 21.5% identity (53.5% similar) in 391 aa overlap (9-396:20-369)

                          10        20        30        40         
pF1KB8            MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTV
                          : . ::.  :... . .. .:  ..   ...     . . .
XP_006 MDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVD-EPESHVTTIETF-----ITYRI
               10        20        30         40             50    

      50        60        70        80        90       100         
pF1KB8 HTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKL
        :::.   :.: :: : :...::.::.  : :.  .  ::::: : :    :  :..   
XP_006 ITKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEA--HPTLIIPPLPEKFIVKGMVERF---
           60        70        80          90       100            

     110       120       130       140       150       160         
pF1KB8 GEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYD
               ...:      .:..  :. :        ::.:...::.:. ...:..::  .
XP_006 --------NDDF------IETRRKALHK--------FLNRIADHPTLTFNEDFKIFLTAQ
             110             120               130       140       

     170        180       190       200       210       220        
pF1KB8 Q-DLSVRRKNTKEMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIKDSCV
         .:: ..:.   ... . ..:   :. .   :::.  . : . .::.  . ..:.    
XP_006 AWELSSHKKQGPGLLSRMGQTVRAVASSM--RGVKNRPEEFMEMNNFIELFSQKINLIDK
       150       160       170         180       190       200     

      230       240       250         260       270       280      
pF1KB8 KADKMTRSHKNVADDYIHTAACLHSL--ALEEPTVIKKYLLKVAELFEKLRKVEGRVSSD
        .... . ...  :. ..  . .: :  : ::  :    :  ::  ...  :.  .  : 
XP_006 ISQRIYKEEREYFDE-MKEYGPIHILWSASEEDLV--DTLKDVASCIDRCCKATEKRMSG
         210       220        230         240       250       260  

        290       300       310       320       330       340      
pF1KB8 EDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQEC
        .  :  ... :.:  :    .. :: .   . ... ..:     :. :. :   .  . 
XP_006 LSEALLPVVHEYVLYSEMLMGVMKRRDQIQAELDSKVEVL---TYKKADTDLLPEEIGKL
            270       280       290       300          310         

        350       360       370       380       390       400      
pF1KB8 CQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN  
        .: :  ... : .   .:..    ..  . .:.: .:.. .. ..  .:          
XP_006 EDKVECANNALKADWERWKQNMQNDIKLAFTDMAEENIHYYEQCLATWESFLTSQTNLHL
     320       330       340       350       360       370         

XP_006 EEASEDKP
     380       

>>XP_016856915 (OMIM: 614904) PREDICTED: sorting nexin-7  (387 aa)
 initn: 213 init1:  95 opt: 179  Z-score: 184.8  bits: 43.0 E(85289): 0.0015
Smith-Waterman score: 219; 21.5% identity (53.5% similar) in 391 aa overlap (9-396:20-369)

                          10        20        30        40         
pF1KB8            MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTV
                          : . ::.  :... . .. .:  ..   ...     . . .
XP_016 MDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVD-EPESHVTTIETF-----ITYRI
               10        20        30         40             50    

      50        60        70        80        90       100         
pF1KB8 HTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKL
        :::.   :.: :: : :...::.::.  : :.  .  ::::: : :    :  :..   
XP_016 ITKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEA--HPTLIIPPLPEKFIVKGMVERF---
           60        70        80          90       100            

     110       120       130       140       150       160         
pF1KB8 GEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYD
               ...:      .:..  :. :        ::.:...::.:. ...:..::  .
XP_016 --------NDDF------IETRRKALHK--------FLNRIADHPTLTFNEDFKIFLTAQ
             110             120               130       140       

     170        180       190       200       210       220        
pF1KB8 Q-DLSVRRKNTKEMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIKDSCV
         .:: ..:.   ... . ..:   :. .   :::.  . : . .::.  . ..:.    
XP_016 AWELSSHKKQGPGLLSRMGQTVRAVASSM--RGVKNRPEEFMEMNNFIELFSQKINLIDK
       150       160       170         180       190       200     

      230       240       250         260       270       280      
pF1KB8 KADKMTRSHKNVADDYIHTAACLHSL--ALEEPTVIKKYLLKVAELFEKLRKVEGRVSSD
        .... . ...  :. ..  . .: :  : ::  :    :  ::  ...  :.  .  : 
XP_016 ISQRIYKEEREYFDE-MKEYGPIHILWSASEEDLV--DTLKDVASCIDRCCKATEKRMSG
         210       220        230         240       250       260  

        290       300       310       320       330       340      
pF1KB8 EDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQEC
        .  :  ... :.:  :    .. :: .   . ... ..:     :. :. :   .  . 
XP_016 LSEALLPVVHEYVLYSEMLMGVMKRRDQIQAELDSKVEVL---TYKKADTDLLPEEIGKL
            270       280       290       300          310         

        350       360       370       380       390       400      
pF1KB8 CQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN  
        .: :  ... : .   .:..    ..  . .:.: .:.. .. ..  .:          
XP_016 EDKVECANNALKADWERWKQNMQNDIKLAFTDMAEENIHYYEQCLATWESFLTSQTNLHL
     320       330       340       350       360       370         

XP_016 EEASEDKP
     380       




404 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 10:04:30 2016 done: Fri Nov  4 10:04:31 2016
 Total Scan time:  5.100 Total Display time:  0.020

Function used was FASTA [36.3.4 Apr, 2011]
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