Result of FASTA (ccds) for pF1KB5319
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5319, 426 aa
  1>>>pF1KB5319 426 - 426 aa - 426 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.6353+/-0.000916; mu= 2.2241+/- 0.055
 mean_var=170.8892+/-34.510, 0's: 0 Z-trim(112.3): 17  B-trim: 0 in 0/52
 Lambda= 0.098111
 statistics sampled from 13039 (13055) to 13039 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.754), E-opt: 0.2 (0.401), width:  16
 Scan time:  3.290

The best scores are:                                      opt bits E(32554)
CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13          ( 430) 2588 378.2 8.3e-105
CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15         ( 425) 1890 279.4 4.5e-75
CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15         ( 381) 1648 245.1 8.4e-65
CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18         ( 467) 1649 245.3 9.1e-65
CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4           ( 465) 1580 235.6 7.9e-62
CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5          ( 465) 1431 214.5 1.8e-55
CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15         ( 320) 1392 208.9 5.9e-54
CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13         ( 467) 1388 208.4 1.2e-53
CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15         ( 230) 1139 173.0 2.7e-43
CCDS11950.1 SMAD4 gene_id:4089|Hs108|chr18         ( 552)  471 78.6 1.6e-14


>>CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13               (430 aa)
 initn: 2389 init1: 2389 opt: 2588  Z-score: 1995.1  bits: 378.2 E(32554): 8.3e-105
Smith-Waterman score: 2588; 85.4% identity (94.1% similar) in 426 aa overlap (3-426:7-430)

                   10        20        30        40        50      
pF1KB5     MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS
             ..:::::::::::::::::::::::::::::::.::::::::::::.:::.:::
CCDS93 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
               10        20        30        40        50        60

         60        70        80        90       100       110      
pF1KB5 CPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
       ::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
               70        80        90       100       110       120

        120       130       140       150       160        170     
pF1KB5 QKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG-QNEPHMPLNATFPDS
       :::::::::::.:::.::::::::::::::::: ::::.::. . ..:: :: :::.:::
CCDS93 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
              130       140       150       160       170       180

         180       190       200        210       220       230    
pF1KB5 FQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTS-SDPGSPFQMPDVQAVAYEEPKHWCS
       ::::    .: ::. .. .:: ..:  ::::: : :.: ::.:  : . : ::::.::::
CCDS93 FQQPPCSALPPSPSHAFSQSPCTAS--YPHSPGSPSEPESPYQHSDFRPVCYEEPQHWCS
              190       200         210       220       230        

          240       250       260       270       280       290    
pF1KB5 IVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKG
       ..::::::::::.:.::: :::.:::::::::.:::::::::::::::::::::::::::
CCDS93 VAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKG
      240       250       260       270       280       290        

          300       310       320       330       340       350    
pF1KB5 VHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLA
       ::::::::::::::.::::::::::::::.:::::.::::::::::::.:::: ::::::
CCDS93 VHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLA
      300       310       320       330       340       350        

          360       370       380       390       400       410    
pF1KB5 QSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQ
       :::.::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 QSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQ
      360       370       380       390       400       410        

          420      
pF1KB5 MGSPHNPISSVS
       ::::::::::::
CCDS93 MGSPHNPISSVS
      420       430

>>CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15              (425 aa)
 initn: 1042 init1: 913 opt: 1890  Z-score: 1461.2  bits: 279.4 E(32554): 4.5e-75
Smith-Waterman score: 1890; 65.1% identity (82.5% similar) in 435 aa overlap (3-426:1-425)

               10        20           30        40        50       
pF1KB5 MNVTSLFSFTSPAVKRLLGWKQGDE---EEKWAEKAVDALVKKLKKKKGAMEELEKALSC
         ..:.. :: : ::::::::.:..   :::: :::: .:::::::  : ..:::::.. 
CCDS10   MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEKAITT
                 10        20        30        40         50       

        60        70        80        90       100       110       
pF1KB5 PGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQ
        .  ..:.:::::::::::::::::::::::::.::::::.:::::. .: ::: :. :.
CCDS10 QNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKK
        60        70        80        90       100       110       

       120       130       140       150       160       170       
pF1KB5 KEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQ
        :::.:::::.:::.:::::::::::.:  :     :.:  : .    .: :..:: ...
CCDS10 DEVCVNPYHYQRVETPVLPPVLVPRHTEI-P-----AEFPPLDDYSHSIPENTNFPAGIE
       120       130       140             150       160       170 

       180       190       200        210              220         
pF1KB5 QPNSHPFPHSPNSSYPNSPGSSSS-TYPHSPTSSDPG-SPFQM-P-----DVQAVAYEEP
        :.:. .:..:  .: .  : .:.  . ::  ...:. ::  : :     :.: :.: ::
CCDS10 -PQSN-IPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEP
               180       190       200       210       220         

     230       240       250       260       270       280         
pF1KB5 KHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRR
         :::: :::::.::::.::::. :. :::::::::.. :::::::::::::...: :::
CCDS10 AFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRR
     230       240       250       260        270       280        

     290       300       310       320       330       340         
pF1KB5 HIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEF
       :::.::.:::.::::.:::::::.::::: ::: ..:.::.:::::: ::.:::::::::
CCDS10 HIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEF
      290       300       310       320       330       340        

     350       360       370       380       390       400         
pF1KB5 AQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLD
       : :::::::.:::.::.::.::::::::::::::::.:: :::::::::.::.:::::::
CCDS10 AALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLD
      350       360       370       380       390       400        

     410       420      
pF1KB5 KVLTQMGSPHNPISSVS
       :::::::::    ::::
CCDS10 KVLTQMGSPSIRCSSVS
      410       420     

>>CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15              (381 aa)
 initn: 942 init1: 913 opt: 1648  Z-score: 1276.8  bits: 245.1 E(32554): 8.4e-65
Smith-Waterman score: 1648; 66.9% identity (83.3% similar) in 366 aa overlap (69-426:25-381)

       40        50        60        70        80        90        
pF1KB5 KKLKKKKGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQ
                                     ::::::::::::::::::::::.::::::.
CCDS45       MSCLHPRQTWKGAALVHRKAWWMGRSLDGRLQVSHRKGLPHVIYCRLWRWPDLH
                     10        20        30        40        50    

      100       110       120       130       140       150        
pF1KB5 SHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRN
       :::::. .: ::: :. :. :::.:::::.:::.:::::::::::.:  :     :.:  
CCDS45 SHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEI-P-----AEFPP
           60        70        80        90       100              

      160       170       180       190       200        210       
pF1KB5 LGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSS-TYPHSPTSSDPG-SPF
       : .    .: :..:: ... :.:. .:..:  .: .  : .:.  . ::  ...:. :: 
CCDS45 LDDYSHSIPENTNFPAGIE-PQSN-IPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPN
      110       120        130        140       150       160      

              220       230       240       250       260       270
pF1KB5 QM-P-----DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRF
        : :     :.: :.: ::  :::: :::::.::::.::::. :. :::::::::.. ::
CCDS45 PMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSE-RF
        170       180       190       200       210       220      

              280       290       300       310       320       330
pF1KB5 CLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPT
       :::::::::::...: ::::::.::.:::.::::.:::::::.::::: ::: ..:.::.
CCDS45 CLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPA
         230       240       250       260       270       280     

              340       350       360       370       380       390
pF1KB5 TVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDV
       :::::: ::.:::::::::: :::::::.:::.::.::.::::::::::::::::.:: :
CCDS45 TVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTV
         290       300       310       320       330       340     

              400       410       420      
pF1KB5 TSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       ::::::::.::.::::::::::::::::    ::::
CCDS45 TSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
         350       360       370       380 

>>CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18              (467 aa)
 initn: 1739 init1: 908 opt: 1649  Z-score: 1276.3  bits: 245.3 E(32554): 9.1e-65
Smith-Waterman score: 1777; 59.3% identity (75.1% similar) in 469 aa overlap (12-426:10-467)

               10        20                     30        40       
pF1KB5 MNVTSLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKGA
                  :.::::::::             :. .:::: :::: .:::::::  : 
CCDS11   MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKT-GR
                 10        20        30        40        50        

        50        60                                      70       
pF1KB5 MEELEKALSCPGQPSNCVTIP------------------------------RSLDGRLQV
       ..:::::..  .  ..:::::                              :::::::::
CCDS11 LDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQV
        60        70        80        90       100       110       

        80        90       100       110       120       130       
pF1KB5 SHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPP
       :::::::::::::.::::::.:::::: .: ::. :. :. :::.:::::.:::.:::::
CCDS11 SHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPP
       120       130       140       150       160       170       

       140       150       160       170       180       190       
pF1KB5 VLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPG
       ::::::.:      .:...  : .    .: :..:: ... :.:. .:..:  .: .  :
CCDS11 VLVPRHTE------ILTELPPLDDYTHSIPENTNFPAGIE-PQSNYIPETPPPGYISEDG
       180             190       200       210        220       230

       200       210                  220       230       240      
pF1KB5 SSSSTYPHSPTSSDPGSPFQM-P----------DVQAVAYEEPKHWCSIVYYELNNRVGE
        .:.   ..  : : ::: .. :          :.: :.: ::  ::::.:::::.::::
CCDS11 ETSDQQLNQ--SMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGE
                240       250       260       270       280        

        250       260       270       280       290       300      
pF1KB5 AFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYA
       .::::. :. :::::::::.. :::::::::::::.:.: ::::::.::.:::.::::.:
CCDS11 TFHASQPSLTVDGFTDPSNSE-RFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFA
      290       300        310       320       330       340       

        310       320       330       340       350       360      
pF1KB5 ECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYE
       ::::::.::::: ::: ..:.::.:::::: ::.:::::::::: :::::::.:::.::.
CCDS11 ECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQ
       350       360       370       380       390       400       

        370       380       390       400       410       420      
pF1KB5 LTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       ::.::::::::::::::::.:: :::::::::.::.::::::::::::::::    ::.:
CCDS11 LTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
       410       420       430       440       450       460       

>>CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4                (465 aa)
 initn: 2996 init1: 1569 opt: 1580  Z-score: 1223.5  bits: 235.6 E(32554): 7.9e-62
Smith-Waterman score: 2880; 91.5% identity (91.5% similar) in 458 aa overlap (1-419:1-458)

               10        20        30        40        50        60
pF1KB5 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN
              130       140       150       160       170       180

              190       200       210                              
pF1KB5 SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMP---------------------
       :::::::::::::::::::::::::::::::::::::::                     
CCDS37 SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ
              190       200       210       220       230       240

                       220       230       240       250       260 
pF1KB5 ------------------DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
                         ::::::::::::::::::::::::::::::::::::::::::
CCDS37 PMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
              250       260       270       280       290       300

             270       280       290       300       310       320 
pF1KB5 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
              310       320       330       340       350       360

             330       340       350       360       370       380 
pF1KB5 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW
              370       380       390       400       410       420

             390       400       410       420      
pF1KB5 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       ::::::::::::::::::::::::::::::::::::::       
CCDS37 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
              430       440       450       460     

>>CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5               (465 aa)
 initn: 2761 init1: 1399 opt: 1431  Z-score: 1109.5  bits: 214.5 E(32554): 1.8e-55
Smith-Waterman score: 2662; 85.0% identity (88.7% similar) in 460 aa overlap (7-426:8-465)

                10        20        30        40        50         
pF1KB5  MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPG
              :::::::::::::::::::::::::::::::::::::::::::::::::: ::
CCDS75 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB5 QPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKE
       :::.:::::::::::::::::::::::::::::::::::::::::::. :::::::::::
CCDS75 QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB5 VCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQP
       ::::::::::::::::::::::::.:.:::::::.:::::..:::::: ::::::::.::
CCDS75 VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP
              130       140       150       160       170       180

     180       190       200       210                             
pF1KB5 NSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMP--------------------
       :. ::: :::: :: ::  .:::::.::.:: ::::::.:                    
CCDS75 NNTPFPLSPNSPYPPSP--ASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNS
              190         200       210       220       230        

                         220       230       240       250         
pF1KB5 --------------------DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDG
                           ::: ::::::::::::::::::::::::::::::::::::
CCDS75 QPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDG
      240       250       260       270       280       290        

     260       270       280       290       300       310         
pF1KB5 FTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSR
       ::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 FTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSR
      300       310       320       330       340       350        

     320       330       340       350       360       370         
pF1KB5 NCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVK
       :::.::::::::::::::.::::::::::::::::::::::::.::::::::::::::::
CCDS75 NCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVK
      360       370       380       390       400       410        

     380       390       400       410       420      
pF1KB5 GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       ::::::::::::::::::::::::::::::::::::::: :::::::
CCDS75 GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
      420       430       440       450       460     

>>CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15              (320 aa)
 initn: 942 init1: 913 opt: 1392  Z-score: 1082.2  bits: 208.9 E(32554): 5.9e-54
Smith-Waterman score: 1392; 64.4% identity (81.8% similar) in 329 aa overlap (106-426:1-320)

          80        90       100       110       120       130     
pF1KB5 QVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVL
                                     .: ::: :. :. :::.:::::.:::.:::
CCDS53                               MELCEFAFNMKKDEVCVNPYHYQRVETPVL
                                             10        20        30

         140       150       160       170       180       190     
pF1KB5 PPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNS
       ::::::::.:  :     :.:  : .    .: :..:: ... :.:. .:..:  .: . 
CCDS53 PPVLVPRHTEI-P-----AEFPPLDDYSHSIPENTNFPAGIE-PQSN-IPETPPPGYLSE
               40              50        60         70         80  

         200        210              220       230       240       
pF1KB5 PGSSSS-TYPHSPTSSDPG-SPFQM-P-----DVQAVAYEEPKHWCSIVYYELNNRVGEA
        : .:.  . ::  ...:. ::  : :     :.: :.: ::  :::: :::::.::::.
CCDS53 DGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGET
             90       100       110       120       130       140  

       250       260       270       280       290       300       
pF1KB5 FHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAE
       ::::. :. :::::::::.. :::::::::::::...: ::::::.::.:::.::::.::
CCDS53 FHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAE
            150       160        170       180       190       200 

       310       320       330       340       350       360       
pF1KB5 CLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYEL
       :::::.::::: ::: ..:.::.:::::: ::.:::::::::: :::::::.:::.::.:
CCDS53 CLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQL
             210       220       230       240       250       260 

       370       380       390       400       410       420      
pF1KB5 TKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       :.::::::::::::::::.:: :::::::::.::.::::::::::::::::    ::::
CCDS53 TRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
             270       280       290       300       310       320

>>CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13              (467 aa)
 initn: 2556 init1: 1344 opt: 1388  Z-score: 1076.6  bits: 208.4 E(32554): 1.2e-53
Smith-Waterman score: 2498; 79.1% identity (87.0% similar) in 460 aa overlap (6-426:10-467)

                   10        20        30        40        50      
pF1KB5     MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS
                ::::::::::::::::::::::::::::::.::::::::::::.:::.:::
CCDS45 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
               10        20        30        40        50        60

         60        70        80        90       100       110      
pF1KB5 CPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
       ::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
               70        80        90       100       110       120

        120       130       140       150       160        170     
pF1KB5 QKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG-QNEPHMPLNATFPDS
       :::::::::::.:::.::::::::::::::::: ::::.::. . ..:: :: :::.:::
CCDS45 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
              130       140       150       160       170       180

         180       190       200        210                        
pF1KB5 FQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTS-SDPGSPFQ-------MP--------
       ::::    .: ::. .. .:: ..:  ::::: : :.: ::.:       .:        
CCDS45 FQQPPCSALPPSPSHAFSQSPCTAS--YPHSPGSPSEPESPYQHSVDTPPLPYHATEASE
              190       200         210       220       230        

                           220       230       240       250       
pF1KB5 ----------------------DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLV
                             : . : ::::.::::..::::::::::.:.::: :::.
CCDS45 TQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLI
      240       250       260       270       280       290        

       260       270       280       290       300       310       
pF1KB5 DGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQ
       :::::::::.:::::::::::::::::::::::::::::::::::::::::.::::::::
CCDS45 DGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQ
      300       310       320       330       340       350        

       320       330       340       350       360       370       
pF1KB5 SRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSF
       ::::::.:::::.::::::::::::.:::: :::::::::.::::.::::::::::::::
CCDS45 SRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSF
      360       370       380       390       400       410        

       380       390       400       410       420      
pF1KB5 VKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       :::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 VKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
      420       430       440       450       460       

>>CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15              (230 aa)
 initn: 942 init1: 913 opt: 1139  Z-score: 890.8  bits: 173.0 E(32554): 2.7e-43
Smith-Waterman score: 1139; 74.9% identity (88.8% similar) in 223 aa overlap (206-426:9-230)

         180       190       200        210        220       230   
pF1KB5 FQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPT-SSDPGSPFQMP-DVQAVAYEEPKHWC
                                     ::. : .: :: .   :.: :.: ::  ::
CCDS53                       MNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWC
                                     10        20        30        

           240       250       260       270       280       290   
pF1KB5 SIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGK
       :: :::::.::::.::::. :. :::::::::.. :::::::::::::...: ::::::.
CCDS53 SISYYELNQRVGETFHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGR
       40        50        60        70         80        90       

           300       310       320       330       340       350   
pF1KB5 GVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLL
       ::.:::.::::.:::::::.::::: ::: ..:.::.:::::: ::.:::::::::: ::
CCDS53 GVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALL
       100       110       120       130       140       150       

           360       370       380       390       400       410   
pF1KB5 AQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLT
       :::::.:::.::.::.::::::::::::::::.:: :::::::::.::.:::::::::::
CCDS53 AQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLT
       160       170       180       190       200       210       

           420      
pF1KB5 QMGSPHNPISSVS
       :::::    ::::
CCDS53 QMGSPSIRCSSVS
       220       230

>>CCDS11950.1 SMAD4 gene_id:4089|Hs108|chr18              (552 aa)
 initn: 696 init1: 225 opt: 471  Z-score: 374.0  bits: 78.6 E(32554): 1.6e-14
Smith-Waterman score: 712; 34.6% identity (58.4% similar) in 433 aa overlap (14-355:20-449)

                     10        20        30        40        50    
pF1KB5       MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKA
                          :. :.  .:: : : .:..:...::::::.::  .. :  :
CCDS11 MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
               10        20        30        40        50        60

            60        70        80        90       100       110   
pF1KB5 LSCPG-QPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPF
       ..  : .::.:::: :.:::::::. :::.::::: :.::::::... ::: .. :.. :
CCDS11 ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQYAF
               70        80        90       100        110         

           120       130                  140          150         
pF1KB5 GSKQKEVCINPYHYKRVESPVL-----------PPVLVPRHS---EYNPQHSLLAQFRNL
         :   ::.:::::.:: :: .           :  .. .     ... : :: .. ...
CCDS11 DLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSI
     120       130       140       150       160       170         

     160       170                  180         190                
pF1KB5 GQNEPHMPLNATFPDSFQQP-----------NSHPFPHSP--NSSYPNS-----------
        :.  : : : .  .... :           ..  ::. :  ..: : :           
CCDS11 -QTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLL
      180       190       200       210       220       230        

                200              210            220                
pF1KB5 -------PGSSSS-------TYPHSPTSSDPGS---PF--QMPDVQA-------------
              ::....       :: :. :..  ::   :.  ..:  :              
CCDS11 QIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHP
      240       250       260       270       280       290        

                           230       240       250         260     
pF1KB5 ---------VAYEEP-------KHWCSIVYYELNNRVGEAFHASSTS--VLVDGFTDPSN
                .:.. :       ..::::.:.:.. .:::.:.. :.   : :::..:::.
CCDS11 GHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSG
      300       310       320       330       340       350        

         270       280       290       300        310       320    
pF1KB5 NKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECLSDSSIFVQSRNCNYH
       . .::::: ::::.:. .:: .: ::::::.:   : :.:...:::: ..::::   . .
CCDS11 G-DRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDRE
       360       370       380       390       400       410       

           330       340       350       360       370       380   
pF1KB5 HGFHP-TTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGA
        :  :  .: ::  .  .:.:. ..  . . :                            
CCDS11 AGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGG
       420       430       440       450       460       470       

           390       400       410       420                       
pF1KB5 EYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS                 
                                                                   
CCDS11 IAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLD
       480       490       500       510       520       530       




426 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 03:36:42 2016 done: Fri Nov  4 03:36:43 2016
 Total Scan time:  3.290 Total Display time:  0.080

Function used was FASTA [36.3.4 Apr, 2011]
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