Result of FASTA (omim) for pF1KA1343
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA1343, 495 aa
  1>>>pF1KA1343 495 - 495 aa - 495 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 13.8855+/-0.000443; mu= -21.0178+/- 0.028
 mean_var=495.8669+/-101.354, 0's: 0 Z-trim(123.0): 47  B-trim: 0 in 0/60
 Lambda= 0.057596
 statistics sampled from 41944 (41991) to 41944 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.782), E-opt: 0.2 (0.492), width:  16
 Scan time: 11.560

The best scores are:                                      opt bits E(85289)
NP_775858 (OMIM: 616019) REST corepressor 2 [Homo  ( 523) 1674 153.5 1.4e-36
XP_005273989 (OMIM: 616019) PREDICTED: REST corepr ( 477) 1280 120.7 9.4e-27
NP_055971 (OMIM: 607675) REST corepressor 1 [Homo  ( 485)  909 89.9 1.8e-17


>>NP_775858 (OMIM: 616019) REST corepressor 2 [Homo sapi  (523 aa)
 initn: 1570 init1: 756 opt: 1674  Z-score: 777.7  bits: 153.5 E(85289): 1.4e-36
Smith-Waterman score: 1898; 60.3% identity (80.2% similar) in 491 aa overlap (1-485:46-513)

                                             10         20         
pF1KA1                               MRVGAEYQARIPEFDP-GATKYTDKDNGGM
                                     .:::..::: :::  : . ..:..:.  ::
NP_775 SRSRAKTVPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGM
          20        30        40        50        60        70     

      30        40        50        60        70        80         
pF1KA1 LVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEW
       ::::: : . :::::.:::.::::::::.:::::::.::::..::::::: :::::::::
NP_775 LVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEW
          80        90       100       110       120       130     

      90       100       110       120       130       140         
pF1KA1 TVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLAN
       ::::::::::::.:::: :.::::::::: : :::::::::::::::::.::::::.:..
NP_775 TVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGG
         140       150       160       170       180       190     

     150       160       170        180       190       200        
pF1KA1 RHNQGDSDDDVEETHPMDGNDSDYDPKK-EAKKEGNTEQPVQTSKIGLGRREYQSLQHRH
       :... :::. .:: .   :. :. .:   . :.:    .:.. .. : :..: :  :.::
NP_775 RKDKEDSDE-LEEGR---GGVSEGEPDPADPKREPLPSRPLN-ARPGPGKKEVQVSQYRH
         200           210       220       230        240       250

      210       220       230       240       250       260        
pF1KA1 HSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQ
       :  :.. ::::::::. : ..::: ::. ::  :: :: .:::::::::. ::.::.:.:
NP_775 HPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQ
              260       270       280       290       300       310

      270       280       290       300       310       320        
pF1KA1 KMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFF
        .::::. ..:::.: :.:.::::.:::::::..:.::::: :::.::::::. :::.::
NP_775 ALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFF
              320       330       340       350       360       370

      330       340       350       360       370       380        
pF1KA1 VNYRRRFNLEEVLQEWEAEQGTQASNGDASTLGEETKSASNVPSGKSTDEEEEAQ----T
       :.::::::::::::::::::  ... : : .  ::.. .. .:.  . .:..:.:    .
NP_775 VSYRRRFNLEEVLQEWEAEQ--DGAPG-APVPMEEARRGAPLPA-PALEEDDEVQITSVS
              380       390          400       410        420      

          390       400       410       420       430       440    
pF1KA1 PQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQPPPLQQQARFIQP
        ..::.. :.:: :   : ::    .:.:::::::: ::.::.: :::::::: .::.::
NP_775 TSVPRSVPPAPPPP---PPPT----SLSQPPPLLRPPLPTAPTLLRQPPPLQQ-GRFLQP
        430       440              450       460       470         

          450       460       470       480       490     
pF1KA1 RPTLNQPPPPLIRPANSMPPRLNPRPVLSTVGGQQPPSLIGIQTDSQSSLH
       : . ::::::::::: . : : . ::     : : ::.:::          
NP_775 RLAPNQPPPPLIRPALAAP-RHSARP-----GPQPPPTLIGTPLEPPAPSL
      480       490        500            510       520   

>>XP_005273989 (OMIM: 616019) PREDICTED: REST corepresso  (477 aa)
 initn: 1363 init1: 756 opt: 1280  Z-score: 601.3  bits: 120.7 E(85289): 9.4e-27
Smith-Waterman score: 1337; 49.2% identity (69.5% similar) in 465 aa overlap (1-459:46-465)

                                             10         20         
pF1KA1                               MRVGAEYQARIPEFDP-GATKYTDKDNGGM
                                     .:::..::: :::  : . ..:..:.  ::
XP_005 SRSRAKTVPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGM
          20        30        40        50        60        70     

      30        40        50        60        70        80         
pF1KA1 LVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEW
       ::::: : . :::::.:::.::::::::.:::::::.::::..::::::: :::::::::
XP_005 LVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEW
          80        90       100       110       120       130     

      90       100       110       120       130       140         
pF1KA1 TVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLAN
       ::::::::::::.:::: :.::::::::: : :::::::::::::::::.::::::.:..
XP_005 TVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGG
         140       150       160       170       180       190     

     150       160       170        180       190       200        
pF1KA1 RHNQGDSDDDVEETHPMDGNDSDYDPKK-EAKKEGNTEQPVQTSKIGLGRREYQSLQHRH
       :... :::. .:: .   :. :. .:   . :.:    .:.. .. : :..: :  :.::
XP_005 RKDKEDSDE-LEEGR---GGVSEGEPDPADPKREPLPSRPLN-ARPGPGKKEVQVSQYRH
         200           210       220       230        240       250

      210       220       230       240       250       260        
pF1KA1 HSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQ
       :  :.. ::::::::. : ..::: ::. ::  :: :: .:::::::::. ::.::.:.:
XP_005 HPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQ
              260       270       280       290       300       310

      270       280       290       300       310       320        
pF1KA1 KMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFF
        .::::. ..:::.: :.:.::::.::::::::            : :: .. . ..   
XP_005 ALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQG-----------PDYIGLHVRAPIS---
              320       330       340                  350         

      330       340       350       360       370       380        
pF1KA1 VNYRRRFNLEEVLQEWEAEQGTQASNGDASTLGEETKSASNVPSGKSTDEEEEAQTPQA-
                           .  :.. ..: :     ..  .:....:  .   ..: : 
XP_005 --------------------APCATTPSTSHL-----AVPATPAAEATFAHGSHSAPTAT
                            360            370       380       390 

       390       400        410       420       430       440      
pF1KA1 PRTLGPSPPAPSST-PTPTAPIATLNQPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRP
       : . :: ::::..  :.:::     .  ::  ::  :.::.     :    ..  ..:  
XP_005 PTAAGPLPPAPAGPQPAPTASHPPRSGCPPPQRPPWPSAPTHPDWNPSGAPSTLTLSP-D
             400       410       420       430       440        450

        450         460       470       480       490     
pF1KA1 TLNQP--PPPLIRPANSMPPRLNPRPVLSTVGGQQPPSLIGIQTDSQSSLH
       .:.::  : ::  :.                                    
XP_005 VLHQPRAPGPLCWPSPGISGVTEDRRD                        
              460       470                               

>>NP_055971 (OMIM: 607675) REST corepressor 1 [Homo sapi  (485 aa)
 initn: 1567 init1: 759 opt: 909  Z-score: 434.6  bits: 89.9 E(85289): 1.8e-17
Smith-Waterman score: 1616; 64.6% identity (84.4% similar) in 384 aa overlap (1-382:105-474)

                                             10          20        
pF1KA1                               MRVGAEYQARIPEFDPG--ATKYTDKDNGG
                                     :::: .::: .:.:::.  : .  ..:: :
NP_055 AAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLG
           80        90       100       110       120       130    

       30        40        50        60        70        80        
pF1KA1 MLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDE
       :::::: ... .:::::::::::::::::.::::::::::::::::::::::::::::::
NP_055 MLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDE
          140       150       160       170       180       190    

       90       100       110       120       130       140        
pF1KA1 WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLA
       ::::::::::::::::::.:::::::::::.::::::.::::::::..::.:::.:::  
NP_055 WTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARK--
          200       210       220       230       240       250    

      150       160       170       180       190       200        
pF1KA1 NRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRH
       ..... .:.:..::..  .  : . : .::.:::     :..:  .   ..: .: : ..
NP_055 QKREREESEDELEEANGNNPIDIEVDQNKESKKE---VPPTET--VPQVKKEKHSTQAKN
            260       270       280          290         300       

      210       220       230       240       250       260        
pF1KA1 HSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQ
          :.: .:::::.:.:::: ::: . .::.:.::::::::.:.:::.:: ::.:::::.
NP_055 ---RAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKE
          310       320       330       340       350       360    

      270       280       290       300       310       320        
pF1KA1 KMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFF
       :..:::: .. ::  :: ::::::::::::::..::::.:::::.::::::.: ::::::
NP_055 KLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFF
          370       380       390       400       410       420    

      330       340       350       360       370       380        
pF1KA1 VNYRRRFNLEEVLQEWEAEQGTQASNGDASTLGEETKSASNVPSGKSTDEEEEAQTPQAP
       ::::::::..:::::::::.: . .:: ..   . .:: .:  : :  .::.::      
NP_055 VNYRRRFNIDEVLQEWEAEHGKEETNGPSNQ--KPVKSPDN--SIKMPEEEDEAPVLDVR
          430       440       450         460         470       480

      390       400       410       420       430       440        
pF1KA1 RTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRPTL
                                                                   
NP_055 YASAS                                                       
                                                                   




495 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 01:29:21 2016 done: Fri Nov  4 01:29:23 2016
 Total Scan time: 11.560 Total Display time:  0.010

Function used was FASTA [36.3.4 Apr, 2011]
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