Result of FASTA (omim) for pF1KB9486
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9486, 1221 aa
  1>>>pF1KB9486 1221 - 1221 aa - 1221 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.1894+/-0.000451; mu= 18.7151+/- 0.028
 mean_var=119.4182+/-23.738, 0's: 0 Z-trim(114.3): 354  B-trim: 123 in 1/51
 Lambda= 0.117365
 statistics sampled from 23674 (24068) to 23674 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.632), E-opt: 0.2 (0.282), width:  16
 Scan time: 14.000

The best scores are:                                      opt bits E(85289)
NP_955387 (OMIM: 607512,615458) A disintegrin and  (1221) 8724 1489.7       0
XP_011521225 (OMIM: 607512,615458) PREDICTED: A di (1049) 6986 1195.4       0
NP_001313287 (OMIM: 607512,615458) A disintegrin a (1049) 6986 1195.4       0
XP_016878477 (OMIM: 607512,615458) PREDICTED: A di ( 809) 5951 1020.0       0
XP_016878478 (OMIM: 607512,615458) PREDICTED: A di ( 809) 5951 1020.0       0
XP_011521226 (OMIM: 607512,615458) PREDICTED: A di ( 978) 5868 1006.0       0
NP_620687 (OMIM: 607510) A disintegrin and metallo (1224) 5032 864.6       0
XP_011541423 (OMIM: 605008) PREDICTED: A disintegr ( 863) 2312 403.9 2.4e-111
XP_011541419 (OMIM: 605008) PREDICTED: A disintegr ( 966) 2312 403.9 2.6e-111
XP_011541416 (OMIM: 605008) PREDICTED: A disintegr (1117) 2312 404.0 2.8e-111
NP_922932 (OMIM: 605008) A disintegrin and metallo (1117) 2312 404.0 2.8e-111
XP_011541415 (OMIM: 605008) PREDICTED: A disintegr (1117) 2312 404.0 2.8e-111
NP_112217 (OMIM: 606184) A disintegrin and metallo (1594) 2275 397.9 2.8e-109
NP_055087 (OMIM: 605009) A disintegrin and metallo (1686) 2233 390.8 4.1e-107
XP_005254194 (OMIM: 605009) PREDICTED: A disintegr (1689) 2233 390.8 4.1e-107
XP_016865394 (OMIM: 606184) PREDICTED: A disintegr (1631) 2172 380.4 5.1e-104
XP_011541425 (OMIM: 605008) PREDICTED: A disintegr ( 738) 2162 378.4 9.3e-104
XP_016865395 (OMIM: 606184) PREDICTED: A disintegr (1467) 2162 378.7 1.5e-103
NP_891550 (OMIM: 605421) A disintegrin and metallo (1935) 2108 369.7 1.1e-100
XP_016882827 (OMIM: 277600,608990) PREDICTED: A di (1103) 2096 367.4 2.9e-100
NP_112219 (OMIM: 277600,608990) A disintegrin and  (1103) 2096 367.4 2.9e-100
XP_011541426 (OMIM: 605008) PREDICTED: A disintegr ( 673) 1874 329.6 4.2e-89
XP_011537056 (OMIM: 611681) PREDICTED: A disintegr (1911) 1836 323.6 7.7e-87
NP_079279 (OMIM: 611681) A disintegrin and metallo (1910) 1819 320.7 5.6e-86
XP_011541422 (OMIM: 605008) PREDICTED: A disintegr ( 868) 1740 307.0 3.4e-82
XP_011541421 (OMIM: 605008) PREDICTED: A disintegr ( 892) 1740 307.0 3.5e-82
XP_006722980 (OMIM: 277600,608990) PREDICTED: A di ( 784) 1710 301.9 1.1e-80
NP_001305710 (OMIM: 605421) A disintegrin and meta (1907) 1673 296.0 1.6e-78
XP_005254929 (OMIM: 607511,613195) PREDICTED: A di (1122) 1661 293.8 4.3e-78
XP_011541424 (OMIM: 605008) PREDICTED: A disintegr ( 827) 1644 290.8 2.6e-77
XP_016877464 (OMIM: 607511,613195) PREDICTED: A di (1166) 1577 279.6 8.5e-74
XP_016882828 (OMIM: 277600,608990) PREDICTED: A di ( 626) 1549 274.6 1.5e-72
XP_016882829 (OMIM: 277600,608990) PREDICTED: A di ( 624) 1547 274.2 1.8e-72
XP_016875468 (OMIM: 611681) PREDICTED: A disintegr (1506) 1429 254.6 3.6e-66
XP_011530724 (OMIM: 605011) PREDICTED: A disintegr (1177) 1396 248.9 1.4e-64
XP_011530723 (OMIM: 605011) PREDICTED: A disintegr (1186) 1396 248.9 1.5e-64
NP_055058 (OMIM: 605011) A disintegrin and metallo (1205) 1396 248.9 1.5e-64
XP_011541427 (OMIM: 605008) PREDICTED: A disintegr ( 628) 1384 246.6 3.7e-64
XP_011541417 (OMIM: 605008) PREDICTED: A disintegr (1067) 1386 247.2 4.4e-64
XP_011541418 (OMIM: 605008) PREDICTED: A disintegr (1021) 1384 246.8 5.3e-64
NP_001311441 (OMIM: 606184) A disintegrin and meta (1509) 1338 239.2 1.6e-61
XP_016865552 (OMIM: 225410,604539) PREDICTED: A di (1046) 1334 238.4 1.9e-61
NP_055059 (OMIM: 225410,604539) A disintegrin and  (1211) 1334 238.4 2.1e-61
XP_011537602 (OMIM: 607506) PREDICTED: A disintegr (1056) 1317 235.5 1.4e-60
NP_631894 (OMIM: 607506) A disintegrin and metallo (1226) 1312 234.7 2.8e-60
XP_011537605 (OMIM: 607506) PREDICTED: A disintegr ( 820) 1302 232.8 6.9e-60
NP_542453 (OMIM: 607506) A disintegrin and metallo (1223) 1300 232.7 1.2e-59
NP_008969 (OMIM: 605007) A disintegrin and metallo ( 930) 1297 232.1 1.4e-59
XP_011537609 (OMIM: 607506) PREDICTED: A disintegr ( 791) 1285 230.0 4.9e-59
XP_011537608 (OMIM: 607506) PREDICTED: A disintegr ( 791) 1285 230.0 4.9e-59


>>NP_955387 (OMIM: 607512,615458) A disintegrin and meta  (1221 aa)
 initn: 8724 init1: 8724 opt: 8724  Z-score: 7985.7  bits: 1489.7 E(85289):    0
Smith-Waterman score: 8724; 99.8% identity (99.8% similar) in 1221 aa overlap (1-1221:1-1221)

               10        20        30        40        50        60
pF1KB9 MECALLLACAFRAAGSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDD
       ::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 MECALLLACAFPAAGSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 YVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 YVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 HFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 HFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 LPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 LPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 TEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 TEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 ADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 ADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHH
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 ADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 ADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSC
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 TINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 TINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB9 YLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 YLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB9 CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSE
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB9 CSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 CSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB9 KPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 KPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVC
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB9 ELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 ELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB9 ELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 ELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNET
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB9 LVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAIC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 LVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAIC
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB9 LRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 LRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQ
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB9 KKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 KKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB9 SAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: 
NP_955 SAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCS
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB9 EKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 EKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCG
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB9 GGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 GGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQ
             1150      1160      1170      1180      1190      1200

             1210      1220 
pF1KB9 HGVCNHKFYGKQCCKSCTRKI
       :::::::::::::::::::::
NP_955 HGVCNHKFYGKQCCKSCTRKI
             1210      1220 

>>XP_011521225 (OMIM: 607512,615458) PREDICTED: A disint  (1049 aa)
 initn: 6986 init1: 6986 opt: 6986  Z-score: 6396.2  bits: 1195.4 E(85289):    0
Smith-Waterman score: 6986; 99.7% identity (99.8% similar) in 965 aa overlap (257-1221:85-1049)

        230       240       250       260       270       280      
pF1KB9 YSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSA
                                     :. :::::::::::::::::::::::::::
XP_011 PQVTFPMHLRVERQSITIEGCKSSIFVDDARNVYAPKPPTEDTYLRFDEYGSSGRPRRSA
           60        70        80        90       100       110    

        290       300       310       320       330       340      
pF1KB9 GKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLI
          120       130       140       150       160       170    

        350       360       370       380       390       400      
pF1KB9 LLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLG
          180       190       200       210       220       230    

        410       420       430       440       450       460      
pF1KB9 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLT
          240       250       260       270       280       290    

        470       480       490       500       510       520      
pF1KB9 GNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFG
          300       310       320       330       340       350    

        530       540       550       560       570       580      
pF1KB9 AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPR
          360       370       380       390       400       410    

        590       600       610       620       630       640      
pF1KB9 PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNEN
          420       430       440       450       460       470    

        650       660       670       680       690       700      
pF1KB9 SLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTP
          480       490       500       510       520       530    

        710       720       730       740       750       760      
pF1KB9 CSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYP
          540       550       560       570       580       590    

        770       780       790       800       810       820      
pF1KB9 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN
          600       610       620       630       640       650    

        830       840       850       860       870       880      
pF1KB9 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECS
          660       670       680       690       700       710    

        890       900       910       920       930       940      
pF1KB9 VSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKA
          720       730       740       750       760       770    

        950       960       970       980       990      1000      
pF1KB9 CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKT
          780       790       800       810       820       830    

       1010      1020      1030      1040      1050      1060      
pF1KB9 CGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSA
          840       850       860       870       880       890    

       1070      1080      1090      1100      1110      1120      
pF1KB9 TCGLGVRKREMKCREKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAG
       ::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAG
          900       910       920       930       940       950    

       1130      1140      1150      1160      1170      1180      
pF1KB9 WYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDP
          960       970       980       990      1000      1010    

       1190      1200      1210      1220 
pF1KB9 SCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
       :::::::::::::::::::::::::::::::::::
XP_011 SCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
         1020      1030      1040         

>>NP_001313287 (OMIM: 607512,615458) A disintegrin and m  (1049 aa)
 initn: 6986 init1: 6986 opt: 6986  Z-score: 6396.2  bits: 1195.4 E(85289):    0
Smith-Waterman score: 6986; 99.7% identity (99.8% similar) in 965 aa overlap (257-1221:85-1049)

        230       240       250       260       270       280      
pF1KB9 YSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSA
                                     :. :::::::::::::::::::::::::::
NP_001 PQVTFPMHLRVERQSITIEGCKSSIFVDDARNVYAPKPPTEDTYLRFDEYGSSGRPRRSA
           60        70        80        90       100       110    

        290       300       310       320       330       340      
pF1KB9 GKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLI
          120       130       140       150       160       170    

        350       360       370       380       390       400      
pF1KB9 LLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLG
          180       190       200       210       220       230    

        410       420       430       440       450       460      
pF1KB9 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLT
          240       250       260       270       280       290    

        470       480       490       500       510       520      
pF1KB9 GNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFG
          300       310       320       330       340       350    

        530       540       550       560       570       580      
pF1KB9 AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPR
          360       370       380       390       400       410    

        590       600       610       620       630       640      
pF1KB9 PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNEN
          420       430       440       450       460       470    

        650       660       670       680       690       700      
pF1KB9 SLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTP
          480       490       500       510       520       530    

        710       720       730       740       750       760      
pF1KB9 CSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYP
          540       550       560       570       580       590    

        770       780       790       800       810       820      
pF1KB9 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN
          600       610       620       630       640       650    

        830       840       850       860       870       880      
pF1KB9 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECS
          660       670       680       690       700       710    

        890       900       910       920       930       940      
pF1KB9 VSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKA
          720       730       740       750       760       770    

        950       960       970       980       990      1000      
pF1KB9 CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKT
          780       790       800       810       820       830    

       1010      1020      1030      1040      1050      1060      
pF1KB9 CGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSA
          840       850       860       870       880       890    

       1070      1080      1090      1100      1110      1120      
pF1KB9 TCGLGVRKREMKCREKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAG
       ::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAG
          900       910       920       930       940       950    

       1130      1140      1150      1160      1170      1180      
pF1KB9 WYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDP
          960       970       980       990      1000      1010    

       1190      1200      1210      1220 
pF1KB9 SCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
       :::::::::::::::::::::::::::::::::::
NP_001 SCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
         1020      1030      1040         

>>XP_016878477 (OMIM: 607512,615458) PREDICTED: A disint  (809 aa)
 initn: 5951 init1: 5951 opt: 5951  Z-score: 5450.5  bits: 1020.0 E(85289):    0
Smith-Waterman score: 5951; 99.9% identity (99.9% similar) in 809 aa overlap (413-1221:1-809)

            390       400       410       420       430       440  
pF1KB9 HDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNF
                                     ::::::::::::::::::::::::::::::
XP_016                               MCSKYRSCTINEDTGLGLAFTIAHESGHNF
                                             10        20        30

            450       460       470       480       490       500  
pF1KB9 GMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAG
               40        50        60        70        80        90

            510       520       530       540       550       560  
pF1KB9 QYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAE
              100       110       120       130       140       150

            570       580       590       600       610       620  
pF1KB9 GTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ
              160       170       180       190       200       210

            630       640       650       660       670       680  
pF1KB9 YGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRC
              220       230       240       250       260       270

            690       700       710       720       730       740  
pF1KB9 KLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCK
              280       290       300       310       320       330

            750       760       770       780       790       800  
pF1KB9 GDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTG
              340       350       360       370       380       390

            810       820       830       840       850       860  
pF1KB9 GWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPK
              400       410       420       430       440       450

            870       880       890       900       910       920  
pF1KB9 VMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTE
              460       470       480       490       500       510

            930       940       950       960       970       980  
pF1KB9 PKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQ
              520       530       540       550       560       570

            990      1000      1010      1020      1030      1040  
pF1KB9 VQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG
              580       590       600       610       620       630

           1050      1060      1070      1080      1090      1100  
pF1KB9 CVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCREKGFQGKLITFPERRCRNIKKP
       ::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_016 CVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKP
              640       650       660       670       680       690

           1110      1120      1130      1140      1150      1160  
pF1KB9 NLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLL
              700       710       720       730       740       750

           1170      1180      1190      1200      1210      1220 
pF1KB9 HQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
              760       770       780       790       800         

>>XP_016878478 (OMIM: 607512,615458) PREDICTED: A disint  (809 aa)
 initn: 5951 init1: 5951 opt: 5951  Z-score: 5450.5  bits: 1020.0 E(85289):    0
Smith-Waterman score: 5951; 99.9% identity (99.9% similar) in 809 aa overlap (413-1221:1-809)

            390       400       410       420       430       440  
pF1KB9 HDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNF
                                     ::::::::::::::::::::::::::::::
XP_016                               MCSKYRSCTINEDTGLGLAFTIAHESGHNF
                                             10        20        30

            450       460       470       480       490       500  
pF1KB9 GMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAG
               40        50        60        70        80        90

            510       520       530       540       550       560  
pF1KB9 QYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAE
              100       110       120       130       140       150

            570       580       590       600       610       620  
pF1KB9 GTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ
              160       170       180       190       200       210

            630       640       650       660       670       680  
pF1KB9 YGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRC
              220       230       240       250       260       270

            690       700       710       720       730       740  
pF1KB9 KLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCK
              280       290       300       310       320       330

            750       760       770       780       790       800  
pF1KB9 GDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTG
              340       350       360       370       380       390

            810       820       830       840       850       860  
pF1KB9 GWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPK
              400       410       420       430       440       450

            870       880       890       900       910       920  
pF1KB9 VMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTE
              460       470       480       490       500       510

            930       940       950       960       970       980  
pF1KB9 PKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQ
              520       530       540       550       560       570

            990      1000      1010      1020      1030      1040  
pF1KB9 VQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG
              580       590       600       610       620       630

           1050      1060      1070      1080      1090      1100  
pF1KB9 CVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCREKGFQGKLITFPERRCRNIKKP
       ::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_016 CVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKP
              640       650       660       670       680       690

           1110      1120      1130      1140      1150      1160  
pF1KB9 NLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLL
              700       710       720       730       740       750

           1170      1180      1190      1200      1210      1220 
pF1KB9 HQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
              760       770       780       790       800         

>>XP_011521226 (OMIM: 607512,615458) PREDICTED: A disint  (978 aa)
 initn: 6112 init1: 5863 opt: 5868  Z-score: 5373.5  bits: 1006.0 E(85289):    0
Smith-Waterman score: 6314; 92.4% identity (92.5% similar) in 965 aa overlap (257-1221:85-978)

        230       240       250       260       270       280      
pF1KB9 YSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSA
                                     :. :::::::::::::::::::::::::::
XP_011 PQVTFPMHLRVERQSITIEGCKSSIFVDDARNVYAPKPPTEDTYLRFDEYGSSGRPRRSA
           60        70        80        90       100       110    

        290       300       310       320       330       340      
pF1KB9 GKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLI
          120       130       140       150       160       170    

        350       360       370       380       390       400      
pF1KB9 LLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLG
          180       190       200       210       220       230    

        410       420       430       440       450       460      
pF1KB9 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLT
          240       250       260       270       280       290    

        470       480       490       500       510       520      
pF1KB9 GNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFG
          300       310       320       330       340       350    

        530       540       550       560       570       580      
pF1KB9 AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPR
          360       370       380       390       400       410    

        590       600       610       620       630       640      
pF1KB9 PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNEN
          420       430       440       450       460       470    

        650       660       670       680       690       700      
pF1KB9 SLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTP
          480       490       500       510       520       530    

        710       720       730       740       750       760      
pF1KB9 CSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYP
          540       550       560       570       580       590    

        770       780       790       800       810       820      
pF1KB9 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN
          600       610       620       630       640       650    

        830       840       850       860       870       880      
pF1KB9 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECS
          660       670       680       690       700       710    

        890       900       910       920       930       940      
pF1KB9 VSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKA
          720       730       740       750       760       770    

        950       960       970       980       990      1000      
pF1KB9 CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKT
          780       790       800       810       820       830    

       1010      1020      1030      1040      1050      1060      
pF1KB9 CGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::  
XP_011 CGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSEC--
          840       850       860       870       880       890    

       1070      1080      1090      1100      1110      1120      
pF1KB9 TCGLGVRKREMKCREKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAG
                                                                   
XP_011 ------------------------------------------------------------
                                                                   

       1130      1140      1150      1160      1170      1180      
pF1KB9 WYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDP
                :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ---------TVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDP
                     900       910       920       930       940   

       1190      1200      1210      1220 
pF1KB9 SCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
       :::::::::::::::::::::::::::::::::::
XP_011 SCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
           950       960       970        

>>NP_620687 (OMIM: 607510) A disintegrin and metalloprot  (1224 aa)
 initn: 4669 init1: 3042 opt: 5032  Z-score: 4607.2  bits: 864.6 E(85289):    0
Smith-Waterman score: 5032; 56.2% identity (79.6% similar) in 1226 aa overlap (20-1219:9-1221)

               10        20            30        40            50  
pF1KB9 MECALLLACAFRAAGSGPPRGLAGL----GRVAKALQLCCLCCASVAAALAS----DSSS
                          ::::.:    ..::.    : .  :..: .  :       .
NP_620            MKPRARGWRGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPA
                          10        20        30        40         

               60        70        80        90        100         
pF1KB9 GASGLND--DYVFVTPVEVDSAGSYISHDILHNGRKKRSAQNAR-SSLHYRFSAFGQELH
          :  .  .: .:.  :::  :.:.::.:.:. :..:..  ..  ::: :...  ...:
NP_620 ERPGWMEKGEYDLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFH
      50        60        70        80        90       100         

     110        120       130        140       150       160       
pF1KB9 LELKPSA-ILSSHFIVQVLGKDGASETQK-PEVQQCFYQGFIRNDSSSSVAVSTCAGLSG
       ..:. :. ...  ::::.::: :.. .:  :  . ::::: .:.  .::::.::: ::::
NP_620 MDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSG
     110       120       130       140       150       160         

       170       180       190       200       210       220       
pF1KB9 LIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGY
       .:::.. .... :::. :. . . .. ..   ::::::..: .         ..:..   
NP_620 MIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWE--
     170       180       190       200       210       220         

       230        240       250       260       270       280      
pF1KB9 SPSHIP-HASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSA
         .: : :.:. :         :::::::::::: :.:: :: ..  ::: :  : .:: 
NP_620 -LAHQPLHSSDLRLGLP-----QKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSL
        230       240            250       260       270       280 

        290         300       310       320       330       340    
pF1KB9 GKSQKG--LNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVS
        .:...  ::::::::.::::...::. :.:::.::..::::.::::::::..::...:.
NP_620 LRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVG
             290       300       310       320       330       340 

          350       360       370       380       390       400    
pF1KB9 LILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDT
       :::::.:  ::.:.::::..:.:::::::.:.::.: ::::::::::.::::::::::::
NP_620 LILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDT
             350       360       370       380       390       400 

          410       420       430       440       450       460    
pF1KB9 LGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPT
       ::::::::::::::::::::::::::::::::::::::::::::::: :.:.::::::::
NP_620 LGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPT
             410       420       430       440       450       460 

          470       480       490       500       510       520    
pF1KB9 LTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQ
       :.: ::::::: ::::::.::::: :: ::.:.:: . .::::.::::..:::.::::::
NP_620 LAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQ
             470       480       490       500       510       520 

          530       540       550       560       570       580    
pF1KB9 FGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELG
       :: ::::: : : :::::.:::::.:..::::::::::::.:: .:::: :::::.:. :
NP_620 FGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEG
             530       540       550       560       570       580 

          590       600       610       620       630       640    
pF1KB9 PRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCN
       :.: ::.:: ::.:: :::::::::. . : :.::::..:: :: ::.:  .::: . : 
NP_620 PKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCP
             590       600       610       620       630       640 

          650       660       670       680       690       700    
pF1KB9 ENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDG
       ..:.:::: ::::.::. :::  :.:::::.::..: ::::: ::.:.:::..:.:::::
NP_620 RDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDG
             650       660       670       680       690       700 

          710       720       730       740       750       760    
pF1KB9 TPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEY
       :::: .. .:::::.:: ::::. ::: :: :.::::.:.::.: ...::: ..:..:.:
NP_620 TPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQY
             710       720       730       740       750       760 

          770       780       790       800       810       820    
pF1KB9 YPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRS
       : .: ::.:::::.: :..::.::..::.  ..:::.: :..::::.. :.::::.:.::
NP_620 YHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRS
             770       780       790       800       810       820 

          830       840       850       860        870       880   
pF1KB9 FNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKV-MNGTPPATKRPAYTWSIVQS
       .:.:: : : :::::::. :.:.::.:::.::.:..:..  .  :::  .:.:::.::.:
NP_620 YNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPA--QPSYTWAIVRS
             830       840       850       860         870         

           890       900       910       920       930       940   
pF1KB9 ECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTC
       ::::::::: ..:.  : :: . ::: :::. ::.:::    :.. .::  :  :.::.:
NP_620 ECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSAC
     880       890       900       910       920       930         

           950       960       970       980       990      1000   
pF1KB9 SKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQC
       :..:.:: ::: .::...  ...:  :  ::::  .:.. :::::..::: :: :::..:
NP_620 SRTCGGGAQSRPVQCTRRVHYDSEP-VPASLCPQPAPSSRQACNSQSCPPAWSAGPWAEC
     940       950       960        970       980       990        

          1010      1020          1030      1040      1050         
pF1KB9 SKTCGRGVRKRELLCKGSA----AETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVAS
       :.:::.: ::: . ::..     :. ::.. ::: :.:...:.:.: :: : ..:::..:
NP_620 SHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVS
     1000      1010      1020      1030      1040      1050        

    1060      1070      1080      1090      1100      1110         
pF1KB9 SWSECSATCGLGVRKREMKCREKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHP
       .::.::.::  :..:: .:: ::  .::   .  ..: .. ::.:.::..:    :: ::
NP_620 AWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHP
     1060      1070      1080      1090      1100      1110        

    1120           1130      1140      1150      1160      1170    
pF1KB9 VYNMVAG-----WYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNT
        .  .::     :.. ::.:::..::::::::::.:.  :::.:.::::::: .  ::::
NP_620 PFA-AAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNT
     1120       1130      1140      1150      1160      1170       

         1180      1190      1200      1210      1220  
pF1KB9 NFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI 
       .:::  ::. :  : :.:.::.::::::.:.::::::::::.:..   
NP_620 HFCPIAEKK-DAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTCSKSNL
      1180       1190      1200      1210      1220    

>>XP_011541423 (OMIM: 605008) PREDICTED: A disintegrin a  (863 aa)
 initn: 2090 init1: 896 opt: 2312  Z-score: 2120.1  bits: 403.9 E(85289): 2.4e-111
Smith-Waterman score: 2486; 40.9% identity (67.4% similar) in 860 aa overlap (313-1141:16-862)

            290       300       310       320       330       340  
pF1KB9 RRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVV
                                     ..    : :   :. :..:...:. .:..:
XP_011                MATLMLFTKSLPFNNDICMITLIVGFRVAKLYRDSSLGNVVNIIV
                              10        20        30        40     

            350       360       370                380        390  
pF1KB9 VSLILLEQEPGGLLINHHADQSLNSFCQWQSAL---------IGKNG-KRHDHAILLTGF
       . ::.: ..  .: ::::::.::.:::.::...         : .::  .::.:.:.: .
XP_011 ARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRY
          50        60        70        80        90       100     

            400       410       420       430       440       450  
pF1KB9 DICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNP
       :::..::.:: :::.: ..:::   :::.:::: ::: ::::::: :::::: ::: :: 
XP_011 DICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNS
         110       120       130       140       150       160     

               460       470       480       490       500         
pF1KB9 CR---KAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDK
       :    .  ...:.  .:.:.. ::::.:::.:. .::.. .. :: .:: .  .. ::  
XP_011 CGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKR-DFLYPAV
         170       180       190       200       210        220    

     510       520       530       540       550       560         
pF1KB9 LPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLS
        :::.:::: ::..:.:: .. :. :   ..:. :::   ..:: :. .::::::.:  .
XP_011 APGQVYDADEQCRFQYGATSRQCKYG---EVCRELWCLSKSNRCVTNSIPAAEGTLCQTG
          230       240       250          260       270       280 

     570           580       590       600       610       620     
pF1KB9 M----WCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGG
            :: ::.:: ::   :. : : :. :: :.::::::::::. . :::..: :. ::
XP_011 NIEKGWCYQGDCVPFGTW-PQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGG
             290        300       310       320       330       340

         630       640       650       660       670       680     
pF1KB9 LFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLY
        .: :  . :. :: .::  .: ::: .:::.... :::: .:.:::::    .  : : 
XP_011 KYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKP-CALN
              350       360       370       380       390          

         690       700       710       720       730       740     
pF1KB9 CKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDN
       : ::...:.   .  : ::: :. .. :.::.: :. ::::. ::: :  : : :: ::.
XP_011 CLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDG
     400       410       420       430       440       450         

         750       760       770       780       790       800     
pF1KB9 STCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWS
       :::   .:.. ..   . :. :: :: :.  ::..:. .:..:.:..: .. ::..:.:.
XP_011 STCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWT
     460       470       480       490       500       510         

         810       820       830       840       850       860     
pF1KB9 IDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMN
       :::: .:  :::.:.:.:  ..:: : : :::.:.:.  .:.: .: :: .:. .: . .
XP_011 IDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRT
     520       530       540       550       560       570         

         870        880       890       900        910       920   
pF1KB9 GTPPATKRPAYTWS-IVQSECSVSCGGGYINVKAICLR-DQNTQVNSSFCSAKTKPVTEP
       :.  . .. ..::.    ::::..:.::    ...: : :.:. :....:.  .::  . 
XP_011 GS--GDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQ
     580         590       600       610       620       630       

           930       940       950       960       970       980   
pF1KB9 KICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQV
       . ::.  ::  :. :.:  :::.: ::...: . :..:   ..::.. .: : .  :.. 
XP_011 RACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEK
       640       650       660       670       680       690       

           990      1000      1010      1020       1030      1040  
pF1KB9 QACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSA-AETLPESQCTSLPRPELQEG
       . ::...:::::    ::.:.  :: : ..: .:::.:  ..:.: .::    .: ..  
XP_011 EPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIR
       700       710       720       730       740       750       

           1050      1060      1070      1080           1090       
pF1KB9 CVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCREKGFQG-----KLITFP-----
       : :::::     .::...:..::: :::: . : ..:     :.     . .  :     
XP_011 CSLGRCPPP---RWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQC
       760          770       780       790       800       810    

           1100      1110       1120      1130      1140      1150 
pF1KB9 ERRCRNIKKPNLDLEETCNRRA-CPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV
       : .: .    : .  .  :. : ::    ... .  :    :.:  :: :          
XP_011 ESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYF--RQMCCKTCQGH         
          820       830       840       850         860            

            1160      1170      1180      1190      1200      1210 
pF1KB9 QQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGK

>>XP_011541419 (OMIM: 605008) PREDICTED: A disintegrin a  (966 aa)
 initn: 2264 init1: 896 opt: 2312  Z-score: 2119.5  bits: 403.9 E(85289): 2.6e-111
Smith-Waterman score: 2651; 39.4% identity (65.3% similar) in 1006 aa overlap (167-1141:5-965)

        140       150       160       170       180       190      
pF1KB9 KPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAG
                                     :.: :. .:..: :: .   . ...:   :
XP_011                           MKTHGVIATEDEEYFIEPLKNTTEDSKHFSYENG
                                         10        20        30    

        200       210       220       230       240       250      
pF1KB9 HHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGR
       : :::.::..:   .:. . :  :  .   .. :  :   ..  :  .   ... :.  :
XP_011 H-PHVIYKKSA---LQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHR
            40           50        60        70        80        90

        260       270       280       290       300       310      
pF1KB9 RKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTT
       .:. .       .  ::                     ::::::::: ::  ::. ..  
XP_011 QKRSV-------SIERF---------------------VETLVVADKMMVGYHGRKDIEH
                     100                            110       120  

        320       330       340       350       360       370      
pF1KB9 YILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSAL-
       :::.:::.:. :..:...:. .:..:. ::.: ..  .: ::::::.::.:::.::... 
XP_011 YILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSIL
            130       140       150       160       170       180  

                 380        390       400       410       420      
pF1KB9 --------IGKNG-KRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDT
               : .::  .::.:.:.: .:::..::.:: :::.: ..:::   :::.:::: 
XP_011 SHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDI
            190       200       210       220       230       240  

        430       440       450          460       470       480   
pF1KB9 GLGLAFTIAHESGHNFGMIHDGEGNPCR---KAEGNIMSPTLTGNNGVFSWSSCSRQYLK
       ::: ::::::: :::::: ::: :: :    .  ...:.  .:.:.. ::::.:::.:. 
XP_011 GLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYIT
            250       260       270       280       290       300  

           490       500       510       520       530       540   
pF1KB9 KFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKS
       .::.. .. :: .:: .  .. ::   :::.:::: ::..:.:: .. :. :   ..:. 
XP_011 SFLDSGRGTCLDNEPPKR-DFLYPAVAPGQVYDADEQCRFQYGATSRQCKYG---EVCRE
            310       320        330       340       350           

           550       560       570           580       590         
pF1KB9 LWCHRVGHRCETKFMPAAEGTVCGLSM----WCRQGQCVKFGELGPRPIHGQWSAWSKWS
       :::   ..:: :. .::::::.:  .     :: ::.:: ::   :. : : :. :: :.
XP_011 LWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTW-PQSIDGGWGPWSLWG
      360       370       380       390       400        410       

     600       610       620       630       640       650         
pF1KB9 ECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYN
       ::::::::::. . :::..: :. :: .: :  . :. :: .::  .: ::: .:::...
XP_011 ECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFD
       420       430       440       450       460       470       

     660       670       680       690       700       710         
pF1KB9 SKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGV
       . :::: .:.:::::    .  : : : ::...:.   .  : ::: :. .. :.::.: 
XP_011 NMPFRGKYYNWKPYTGGGVKP-CALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGE
       480       490        500       510       520       530      

     720       730       740       750       760       770         
pF1KB9 CELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEI
       :. ::::. ::: :  : : :: ::.:::   .:.. ..   . :. :: :: :.  ::.
XP_011 CKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEV
        540       550       560       570       580       590      

     780       790       800       810       820       830         
pF1KB9 QELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNE
       .:. .:..:.:..: .. ::..:.:.:::: .:  :::.:.:.:  ..:: : : :::.:
XP_011 REVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSE
        600       610       620       630       640       650      

     840       850       860       870        880       890        
pF1KB9 TLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWS-IVQSECSVSCGGGYINVKA
       .:.  .:.: .: :: .:. .: . .:.  . .. ..::.    ::::..:.::    ..
XP_011 NLIVMVLLQEQNLGIRYKFNVPITRTGS--GDNEVGFTWNHQPWSECSATCAGGVQRQEV
        660       670       680         690       700       710    

      900        910       920       930       940       950       
pF1KB9 ICLR-DQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQ
       .: : :.:. :....:.  .::  . . ::.  ::  :. :.:  :::.: ::...: . 
XP_011 VCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVL
          720       730       740       750       760       770    

       960       970       980       990      1000      1010       
pF1KB9 CVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELL
       :..:   ..::.. .: : .  :.. . ::...:::::    ::.:.  :: : ..: .:
XP_011 CIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVL
          780       790       800       810       820       830    

      1020       1030      1040      1050      1060      1070      
pF1KB9 CKGSA-AETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKRE
       ::.:  ..:.: .::    .: ..  : :::::     .::...:..::: :::: . : 
XP_011 CKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPP---RWVTGDWGQCSAQCGLGQQMRT
          840       850       860          870       880       890 

       1080           1090           1100      1110       1120     
pF1KB9 MKCREKGFQG-----KLITFP-----ERRCRNIKKPNLDLEETCNRRA-CPAHPVYNMVA
       ..:     :.     . .  :     : .: .    : .  .  :. : ::    ... .
XP_011 VQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCS
             900       910       920       930       940       950 

        1130      1140      1150      1160      1170      1180     
pF1KB9 GWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKRED
         :    :.:  :: :                                            
XP_011 RAYF--RQMCCKTCQGH                                           
               960                                                 

>>XP_011541416 (OMIM: 605008) PREDICTED: A disintegrin a  (1117 aa)
 initn: 2264 init1: 896 opt: 2312  Z-score: 2118.7  bits: 404.0 E(85289): 2.8e-111
Smith-Waterman score: 2867; 38.6% identity (66.0% similar) in 1123 aa overlap (59-1141:40-1116)

       30        40        50        60        70        80        
pF1KB9 AKALQLCCLCCASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDILHN--GRK
                                     . : .. :..::. :...:  . ..  .:.
XP_011 WILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKNDKHSRR
      10        20        30        40        50        60         

         90            100       110        120       130       140
pF1KB9 KRSA-----QNARSSLHYRFSAFGQELHLELK-PSAILSSHFIVQVLGKDGASETQKPEV
       .::      :.: :.: ...::.:...::.:   . ..:.:: :.  ::::  . ..  .
XP_011 RRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGP-QWKHDFL
      70        80        90       100       110       120         

              150        160       170       180       190         
pF1KB9 QQCFYQGFIRND-SSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHP
       ..: : :..... :...::.:.:.:: :.: :. .:..: :: .   . ...:   :: :
XP_011 DNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGH-P
      130       140       150       160       170       180        

     200       210       220       230       240       250         
pF1KB9 HVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKK
       ::.::..:   .:. . :  :  .   .. :  :   ..  :  .   ... :.  :.:.
XP_011 HVIYKKSA---LQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKR
       190          200       210       220       230       240    

     260       270       280       290       300       310         
pF1KB9 YAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYIL
        .       .  ::                     ::::::::: ::  ::. ..  :::
XP_011 SV-------SIERF---------------------VETLVVADKMMVGYHGRKDIEHYIL
                 250                            260       270      

     320       330       340       350       360       370         
pF1KB9 TVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSAL----
       .:::.:. :..:...:. .:..:. ::.: ..  .: ::::::.::.:::.::...    
XP_011 SVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQ
        280       290       300       310       320       330      

              380        390       400       410       420         
pF1KB9 -----IGKNG-KRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLG
            : .::  .::.:.:.: .:::..::.:: :::.: ..:::   :::.:::: :::
XP_011 SDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLG
        340       350       360       370       380       390      

     430       440       450          460       470       480      
pF1KB9 LAFTIAHESGHNFGMIHDGEGNPCR---KAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFL
        ::::::: :::::: ::: :: :    .  ...:.  .:.:.. ::::.:::.:. .::
XP_011 SAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFL
        400       410       420       430       440       450      

        490       500       510       520       530       540      
pF1KB9 STPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWC
       .. .. :: .:: .  .. ::   :::.:::: ::..:.:: .. :. :   ..:. :::
XP_011 DSGRGTCLDNEPPKR-DFLYPAVAPGQVYDADEQCRFQYGATSRQCKYG---EVCRELWC
        460       470        480       490       500          510  

        550       560       570           580       590       600  
pF1KB9 HRVGHRCETKFMPAAEGTVCGLSM----WCRQGQCVKFGELGPRPIHGQWSAWSKWSECS
          ..:: :. .::::::.:  .     :: ::.:: ::   :. : : :. :: :.:::
XP_011 LSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTW-PQSIDGGWGPWSLWGECS
            520       530       540       550        560       570 

            610       620       630       640       650       660  
pF1KB9 RTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKP
       :::::::. . :::..: :. :: .: :  . :. :: .::  .: ::: .:::.... :
XP_011 RTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMP
             580       590       600       610       620       630 

            670       680       690       700       710       720  
pF1KB9 FRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCEL
       ::: .:.:::::    .  : : : ::...:.   .  : ::: :. .. :.::.: :. 
XP_011 FRGKYYNWKPYTGGGVKP-CALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKH
             640        650       660       670       680       690

            730       740       750       760       770       780  
pF1KB9 VGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQEL
       ::::. ::: :  : : :: ::.:::   .:.. ..   . :. :: :: :.  ::..:.
XP_011 VGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREV
              700       710       720       730       740       750

            790       800       810       820       830       840  
pF1KB9 QVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLV
        .:..:.:..: .. ::..:.:.:::: .:  :::.:.:.:  ..:: : : :::.:.:.
XP_011 AMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLI
              760       770       780       790       800       810

            850       860       870        880       890       900 
pF1KB9 FEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWS-IVQSECSVSCGGGYINVKAICL
         .:.: .: :: .:. .: . .:.  . .. ..::.    ::::..:.::    ...: 
XP_011 VMVLLQEQNLGIRYKFNVPITRTGS--GDNEVGFTWNHQPWSECSATCAGGVQRQEVVCK
              820       830         840       850       860        

              910       920       930       940       950       960
pF1KB9 R-DQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQ
       : :.:. :....:.  .::  . . ::.  ::  :. :.:  :::.: ::...: . :..
XP_011 RLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIR
      870       880       890       900       910       920        

              970       980       990      1000      1010      1020
pF1KB9 KKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG
       :   ..::.. .: : .  :.. . ::...:::::    ::.:.  :: : ..: .:::.
XP_011 KIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKS
      930       940       950       960       970       980        

              1030      1040      1050      1060      1070         
pF1KB9 SA-AETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKC
       :  ..:.: .::    .: ..  : :::::     .::...:..::: :::: . : ..:
XP_011 SDLSKTFPAAQCPEESKPPVRIRCSLGRCPPP---RWVTGDWGQCSAQCGLGQQMRTVQC
      990      1000      1010      1020         1030      1040     

    1080           1090           1100      1110       1120        
pF1KB9 REKGFQG-----KLITFP-----ERRCRNIKKPNLDLEETCNRRA-CPAHPVYNMVAGWY
            :.     . .  :     : .: .    : .  .  :. : ::    ... .  :
XP_011 LSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAY
        1050      1060      1070      1080      1090      1100     

     1130      1140      1150      1160      1170      1180        
pF1KB9 SLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSC
           :.:  :: :                                               
XP_011 FR--QMCCKTCQGH                                              
          1110                                                     




1221 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 23:52:03 2016 done: Thu Nov  3 23:52:05 2016
 Total Scan time: 14.000 Total Display time:  0.460

Function used was FASTA [36.3.4 Apr, 2011]
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