Result of FASTA (omim) for pF1KB9340
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9340, 766 aa
  1>>>pF1KB9340 766 - 766 aa - 766 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.0742+/-0.00043; mu= 12.7859+/- 0.027
 mean_var=139.0844+/-29.448, 0's: 0 Z-trim(114.4): 514  B-trim: 317 in 1/56
 Lambda= 0.108751
 statistics sampled from 23698 (24247) to 23698 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.638), E-opt: 0.2 (0.284), width:  16
 Scan time: 11.580

The best scores are:                                      opt bits E(85289)
XP_011518857 (OMIM: 609311,611104) PREDICTED: FYVE ( 766) 5085 810.2       0
NP_640334 (OMIM: 609311,611104) FYVE, RhoGEF and P ( 766) 5085 810.2       0
XP_011518858 (OMIM: 609311,611104) PREDICTED: FYVE ( 766) 5085 810.2       0
NP_001291410 (OMIM: 609311,611104) FYVE, RhoGEF an ( 851) 5085 810.3       0
XP_011518856 (OMIM: 609311,611104) PREDICTED: FYVE ( 864) 5085 810.3       0
NP_001291409 (OMIM: 609311,611104) FYVE, RhoGEF an ( 878) 5085 810.3       0
XP_005253361 (OMIM: 609311,611104) PREDICTED: FYVE ( 930) 5085 810.3       0
XP_016874292 (OMIM: 609311,611104) PREDICTED: FYVE ( 914) 4888 779.4       0
NP_001317302 (OMIM: 609311,611104) FYVE, RhoGEF an ( 673) 4478 715.0 2.6e-205
XP_005253366 (OMIM: 609311,611104) PREDICTED: FYVE ( 673) 4478 715.0 2.6e-205
XP_005253365 (OMIM: 609311,611104) PREDICTED: FYVE ( 673) 4478 715.0 2.6e-205
NP_001317303 (OMIM: 609311,611104) FYVE, RhoGEF an ( 673) 4478 715.0 2.6e-205
XP_016874294 (OMIM: 609311,611104) PREDICTED: FYVE ( 582) 3791 607.1 6.5e-173
XP_011518859 (OMIM: 609311,611104) PREDICTED: FYVE ( 582) 3791 607.1 6.5e-173
XP_011518860 (OMIM: 609311,611104) PREDICTED: FYVE ( 567) 3781 605.6 1.9e-172
XP_005253367 (OMIM: 609311,611104) PREDICTED: FYVE ( 518) 3474 557.4 5.6e-158
XP_011518861 (OMIM: 609311,611104) PREDICTED: FYVE ( 511) 3295 529.3 1.6e-149
NP_001291412 (OMIM: 609311,611104) FYVE, RhoGEF an ( 471) 2903 467.7 4.8e-131
NP_001291413 (OMIM: 609311,611104) FYVE, RhoGEF an ( 422) 2842 458.1 3.4e-128
NP_775829 (OMIM: 605091) FYVE, RhoGEF and PH domai ( 655) 2026 330.3 1.6e-89
NP_004454 (OMIM: 300546,305400) FYVE, RhoGEF and P ( 961) 1809 296.3 3.9e-79
XP_016865918 (OMIM: 605091) PREDICTED: FYVE, RhoGE ( 662) 1514 249.9 2.5e-65
XP_011512675 (OMIM: 605091) PREDICTED: FYVE, RhoGE ( 398) 1057 178.1 6.5e-44
NP_060821 (OMIM: 613520) FYVE, RhoGEF and PH domai (1430)  975 165.6 1.3e-39
XP_011512674 (OMIM: 605091) PREDICTED: FYVE, RhoGE ( 401)  910 155.0 5.8e-37
XP_011531725 (OMIM: 614788) PREDICTED: FYVE, RhoGE (1421)  630 111.5 2.6e-23
XP_011531724 (OMIM: 614788) PREDICTED: FYVE, RhoGE (1464)  630 111.5 2.6e-23
NP_001307205 (OMIM: 614788) FYVE, RhoGEF and PH do (1419)  628 111.2 3.2e-23
NP_689749 (OMIM: 614788) FYVE, RhoGEF and PH domai (1462)  628 111.2 3.3e-23
XP_016875801 (OMIM: 602654) PREDICTED: FERM, RhoGE (1045)  480 87.8 2.5e-16
NP_005757 (OMIM: 602654) FERM, RhoGEF and pleckstr (1045)  480 87.8 2.5e-16
NP_060568 (OMIM: 600586) protein ECT2 isoform b [H ( 883)  364 69.6 6.5e-11
NP_001245245 (OMIM: 600586) protein ECT2 isoform b ( 883)  364 69.6 6.5e-11
XP_006713587 (OMIM: 600586) PREDICTED: protein ECT ( 889)  364 69.6 6.5e-11
XP_016861323 (OMIM: 600586) PREDICTED: protein ECT ( 914)  364 69.6 6.7e-11
XP_016861325 (OMIM: 600586) PREDICTED: protein ECT ( 914)  364 69.6 6.7e-11
XP_016861324 (OMIM: 600586) PREDICTED: protein ECT ( 914)  364 69.6 6.7e-11
NP_001245244 (OMIM: 600586) protein ECT2 isoform a ( 914)  364 69.6 6.7e-11
XP_005247233 (OMIM: 600586) PREDICTED: protein ECT ( 927)  364 69.6 6.7e-11
XP_016861322 (OMIM: 600586) PREDICTED: protein ECT ( 927)  364 69.6 6.7e-11
XP_011510818 (OMIM: 600586) PREDICTED: protein ECT ( 927)  364 69.6 6.7e-11
XP_016861321 (OMIM: 600586) PREDICTED: protein ECT ( 927)  364 69.6 6.7e-11
XP_011510816 (OMIM: 600586) PREDICTED: protein ECT ( 958)  364 69.6 6.9e-11
XP_006713586 (OMIM: 600586) PREDICTED: protein ECT ( 958)  364 69.6 6.9e-11
XP_016861319 (OMIM: 600586) PREDICTED: protein ECT ( 958)  364 69.6 6.9e-11
XP_011510817 (OMIM: 600586) PREDICTED: protein ECT ( 958)  364 69.6 6.9e-11
NP_065871 (OMIM: 606905) phosphatidylinositol 3,4, (1659)  367 70.3 7.6e-11
XP_016861327 (OMIM: 600586) PREDICTED: protein ECT ( 854)  361 69.1 8.8e-11
XP_016861326 (OMIM: 600586) PREDICTED: protein ECT ( 854)  361 69.1 8.8e-11
XP_016861320 (OMIM: 600586) PREDICTED: protein ECT ( 929)  361 69.1 9.4e-11


>>XP_011518857 (OMIM: 609311,611104) PREDICTED: FYVE, Rh  (766 aa)
 initn: 5085 init1: 5085 opt: 5085  Z-score: 4320.9  bits: 810.2 E(85289):    0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:1-766)

               10        20        30        40        50        60
pF1KB9 MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB9 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB9 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB9 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB9 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF
              670       680       690       700       710       720

              730       740       750       760      
pF1KB9 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
       ::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
              730       740       750       760      

>>NP_640334 (OMIM: 609311,611104) FYVE, RhoGEF and PH do  (766 aa)
 initn: 5085 init1: 5085 opt: 5085  Z-score: 4320.9  bits: 810.2 E(85289):    0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:1-766)

               10        20        30        40        50        60
pF1KB9 MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB9 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB9 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB9 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB9 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF
              670       680       690       700       710       720

              730       740       750       760      
pF1KB9 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
       ::::::::::::::::::::::::::::::::::::::::::::::
NP_640 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
              730       740       750       760      

>>XP_011518858 (OMIM: 609311,611104) PREDICTED: FYVE, Rh  (766 aa)
 initn: 5085 init1: 5085 opt: 5085  Z-score: 4320.9  bits: 810.2 E(85289):    0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:1-766)

               10        20        30        40        50        60
pF1KB9 MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB9 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB9 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB9 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB9 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF
              670       680       690       700       710       720

              730       740       750       760      
pF1KB9 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
       ::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
              730       740       750       760      

>>NP_001291410 (OMIM: 609311,611104) FYVE, RhoGEF and PH  (851 aa)
 initn: 5085 init1: 5085 opt: 5085  Z-score: 4320.2  bits: 810.3 E(85289):    0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:86-851)

                                             10        20        30
pF1KB9                               MEEIKPASASCVSKEKPSKVSDLISRFEGG
                                     ::::::::::::::::::::::::::::::
NP_001 PPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEGG
          60        70        80        90       100       110     

               40        50        60        70        80        90
pF1KB9 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
         120       130       140       150       160       170     

              100       110       120       130       140       150
pF1KB9 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
         180       190       200       210       220       230     

              160       170       180       190       200       210
pF1KB9 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
         240       250       260       270       280       290     

              220       230       240       250       260       270
pF1KB9 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
         300       310       320       330       340       350     

              280       290       300       310       320       330
pF1KB9 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
         360       370       380       390       400       410     

              340       350       360       370       380       390
pF1KB9 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
         420       430       440       450       460       470     

              400       410       420       430       440       450
pF1KB9 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
         480       490       500       510       520       530     

              460       470       480       490       500       510
pF1KB9 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
         540       550       560       570       580       590     

              520       530       540       550       560       570
pF1KB9 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
         600       610       620       630       640       650     

              580       590       600       610       620       630
pF1KB9 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
         660       670       680       690       700       710     

              640       650       660       670       680       690
pF1KB9 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
         720       730       740       750       760       770     

              700       710       720       730       740       750
pF1KB9 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
         780       790       800       810       820       830     

              760      
pF1KB9 PATLDDHPEPKKKSEC
       ::::::::::::::::
NP_001 PATLDDHPEPKKKSEC
         840       850 

>>XP_011518856 (OMIM: 609311,611104) PREDICTED: FYVE, Rh  (864 aa)
 initn: 5085 init1: 5085 opt: 5085  Z-score: 4320.1  bits: 810.3 E(85289):    0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:99-864)

                                             10        20        30
pF1KB9                               MEEIKPASASCVSKEKPSKVSDLISRFEGG
                                     ::::::::::::::::::::::::::::::
XP_011 PPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEGG
       70        80        90       100       110       120        

               40        50        60        70        80        90
pF1KB9 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
      130       140       150       160       170       180        

              100       110       120       130       140       150
pF1KB9 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
      190       200       210       220       230       240        

              160       170       180       190       200       210
pF1KB9 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
      250       260       270       280       290       300        

              220       230       240       250       260       270
pF1KB9 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
      310       320       330       340       350       360        

              280       290       300       310       320       330
pF1KB9 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
      370       380       390       400       410       420        

              340       350       360       370       380       390
pF1KB9 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
      430       440       450       460       470       480        

              400       410       420       430       440       450
pF1KB9 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
      490       500       510       520       530       540        

              460       470       480       490       500       510
pF1KB9 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
      550       560       570       580       590       600        

              520       530       540       550       560       570
pF1KB9 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
      610       620       630       640       650       660        

              580       590       600       610       620       630
pF1KB9 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
      670       680       690       700       710       720        

              640       650       660       670       680       690
pF1KB9 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
      730       740       750       760       770       780        

              700       710       720       730       740       750
pF1KB9 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
      790       800       810       820       830       840        

              760      
pF1KB9 PATLDDHPEPKKKSEC
       ::::::::::::::::
XP_011 PATLDDHPEPKKKSEC
      850       860    

>>NP_001291409 (OMIM: 609311,611104) FYVE, RhoGEF and PH  (878 aa)
 initn: 5085 init1: 5085 opt: 5085  Z-score: 4320.0  bits: 810.3 E(85289):    0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:113-878)

                                             10        20        30
pF1KB9                               MEEIKPASASCVSKEKPSKVSDLISRFEGG
                                     ::::::::::::::::::::::::::::::
NP_001 PPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEGG
             90       100       110       120       130       140  

               40        50        60        70        80        90
pF1KB9 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
            150       160       170       180       190       200  

              100       110       120       130       140       150
pF1KB9 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
            210       220       230       240       250       260  

              160       170       180       190       200       210
pF1KB9 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
            270       280       290       300       310       320  

              220       230       240       250       260       270
pF1KB9 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
            330       340       350       360       370       380  

              280       290       300       310       320       330
pF1KB9 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
            390       400       410       420       430       440  

              340       350       360       370       380       390
pF1KB9 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
            450       460       470       480       490       500  

              400       410       420       430       440       450
pF1KB9 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
            510       520       530       540       550       560  

              460       470       480       490       500       510
pF1KB9 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
            570       580       590       600       610       620  

              520       530       540       550       560       570
pF1KB9 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
            630       640       650       660       670       680  

              580       590       600       610       620       630
pF1KB9 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
            690       700       710       720       730       740  

              640       650       660       670       680       690
pF1KB9 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
            750       760       770       780       790       800  

              700       710       720       730       740       750
pF1KB9 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
            810       820       830       840       850       860  

              760      
pF1KB9 PATLDDHPEPKKKSEC
       ::::::::::::::::
NP_001 PATLDDHPEPKKKSEC
            870        

>>XP_005253361 (OMIM: 609311,611104) PREDICTED: FYVE, Rh  (930 aa)
 initn: 5085 init1: 5085 opt: 5085  Z-score: 4319.7  bits: 810.3 E(85289):    0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:165-930)

                                             10        20        30
pF1KB9                               MEEIKPASASCVSKEKPSKVSDLISRFEGG
                                     ::::::::::::::::::::::::::::::
XP_005 PPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEGG
          140       150       160       170       180       190    

               40        50        60        70        80        90
pF1KB9 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
          200       210       220       230       240       250    

              100       110       120       130       140       150
pF1KB9 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
          260       270       280       290       300       310    

              160       170       180       190       200       210
pF1KB9 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
          320       330       340       350       360       370    

              220       230       240       250       260       270
pF1KB9 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
          380       390       400       410       420       430    

              280       290       300       310       320       330
pF1KB9 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
          440       450       460       470       480       490    

              340       350       360       370       380       390
pF1KB9 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
          500       510       520       530       540       550    

              400       410       420       430       440       450
pF1KB9 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
          560       570       580       590       600       610    

              460       470       480       490       500       510
pF1KB9 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
          620       630       640       650       660       670    

              520       530       540       550       560       570
pF1KB9 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
          680       690       700       710       720       730    

              580       590       600       610       620       630
pF1KB9 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
          740       750       760       770       780       790    

              640       650       660       670       680       690
pF1KB9 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
          800       810       820       830       840       850    

              700       710       720       730       740       750
pF1KB9 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
          860       870       880       890       900       910    

              760      
pF1KB9 PATLDDHPEPKKKSEC
       ::::::::::::::::
XP_005 PATLDDHPEPKKKSEC
          920       930

>>XP_016874292 (OMIM: 609311,611104) PREDICTED: FYVE, Rh  (914 aa)
 initn: 4888 init1: 4888 opt: 4888  Z-score: 4152.8  bits: 779.4 E(85289):    0
Smith-Waterman score: 4888; 100.0% identity (100.0% similar) in 740 aa overlap (1-740:165-904)

                                             10        20        30
pF1KB9                               MEEIKPASASCVSKEKPSKVSDLISRFEGG
                                     ::::::::::::::::::::::::::::::
XP_016 PPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEGG
          140       150       160       170       180       190    

               40        50        60        70        80        90
pF1KB9 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
          200       210       220       230       240       250    

              100       110       120       130       140       150
pF1KB9 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
          260       270       280       290       300       310    

              160       170       180       190       200       210
pF1KB9 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
          320       330       340       350       360       370    

              220       230       240       250       260       270
pF1KB9 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
          380       390       400       410       420       430    

              280       290       300       310       320       330
pF1KB9 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
          440       450       460       470       480       490    

              340       350       360       370       380       390
pF1KB9 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
          500       510       520       530       540       550    

              400       410       420       430       440       450
pF1KB9 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
          560       570       580       590       600       610    

              460       470       480       490       500       510
pF1KB9 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
          620       630       640       650       660       670    

              520       530       540       550       560       570
pF1KB9 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
          680       690       700       710       720       730    

              580       590       600       610       620       630
pF1KB9 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
          740       750       760       770       780       790    

              640       650       660       670       680       690
pF1KB9 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
          800       810       820       830       840       850    

              700       710       720       730       740       750
pF1KB9 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::          
XP_016 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTERAERNKIRN
          860       870       880       890       900       910    

              760      
pF1KB9 PATLDDHPEPKKKSEC

>>NP_001317302 (OMIM: 609311,611104) FYVE, RhoGEF and PH  (673 aa)
 initn: 4478 init1: 4478 opt: 4478  Z-score: 3806.9  bits: 715.0 E(85289): 2.6e-205
Smith-Waterman score: 4478; 100.0% identity (100.0% similar) in 673 aa overlap (94-766:1-673)

            70        80        90       100       110       120   
pF1KB9 QKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLL
                                     ::::::::::::::::::::::::::::::
NP_001                               MAAQNQMECEEEKAATLSSDTSIQASEPLL
                                             10        20        30

           130       140       150       160       170       180   
pF1KB9 DTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQEREN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQEREN
               40        50        60        70        80        90

           190       200       210       220       230       240   
pF1KB9 GESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRG
              100       110       120       130       140       150

           250       260       270       280       290       300   
pF1KB9 SFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYV
              160       170       180       190       200       210

           310       320       330       340       350       360   
pF1KB9 KGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYL
              220       230       240       250       260       270

           370       380       390       400       410       420   
pF1KB9 RKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNEL
              280       290       300       310       320       330

           430       440       450       460       470       480   
pF1KB9 IKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQN
              340       350       360       370       380       390

           490       500       510       520       530       540   
pF1KB9 EEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSE
              400       410       420       430       440       450

           550       560       570       580       590       600   
pF1KB9 VSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYD
              460       470       480       490       500       510

           610       620       630       640       650       660   
pF1KB9 GGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAW
              520       530       540       550       560       570

           670       680       690       700       710       720   
pF1KB9 CVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAAD
              580       590       600       610       620       630

           730       740       750       760      
pF1KB9 SEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
       :::::::::::::::::::::::::::::::::::::::::::
NP_001 SEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
              640       650       660       670   

>>XP_005253366 (OMIM: 609311,611104) PREDICTED: FYVE, Rh  (673 aa)
 initn: 4478 init1: 4478 opt: 4478  Z-score: 3806.9  bits: 715.0 E(85289): 2.6e-205
Smith-Waterman score: 4478; 100.0% identity (100.0% similar) in 673 aa overlap (94-766:1-673)

            70        80        90       100       110       120   
pF1KB9 QKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLL
                                     ::::::::::::::::::::::::::::::
XP_005                               MAAQNQMECEEEKAATLSSDTSIQASEPLL
                                             10        20        30

           130       140       150       160       170       180   
pF1KB9 DTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQEREN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQEREN
               40        50        60        70        80        90

           190       200       210       220       230       240   
pF1KB9 GESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRG
              100       110       120       130       140       150

           250       260       270       280       290       300   
pF1KB9 SFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYV
              160       170       180       190       200       210

           310       320       330       340       350       360   
pF1KB9 KGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYL
              220       230       240       250       260       270

           370       380       390       400       410       420   
pF1KB9 RKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNEL
              280       290       300       310       320       330

           430       440       450       460       470       480   
pF1KB9 IKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQN
              340       350       360       370       380       390

           490       500       510       520       530       540   
pF1KB9 EEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSE
              400       410       420       430       440       450

           550       560       570       580       590       600   
pF1KB9 VSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYD
              460       470       480       490       500       510

           610       620       630       640       650       660   
pF1KB9 GGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAW
              520       530       540       550       560       570

           670       680       690       700       710       720   
pF1KB9 CVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAAD
              580       590       600       610       620       630

           730       740       750       760      
pF1KB9 SEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
       :::::::::::::::::::::::::::::::::::::::::::
XP_005 SEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
              640       650       660       670   




766 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 23:10:22 2016 done: Thu Nov  3 23:10:23 2016
 Total Scan time: 11.580 Total Display time:  0.220

Function used was FASTA [36.3.4 Apr, 2011]
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