Result of FASTA (omim) for pF1KB9177
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9177, 1138 aa
  1>>>pF1KB9177 1138 - 1138 aa - 1138 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 12.4872+/-0.000661; mu= -11.2530+/- 0.040
 mean_var=784.6081+/-169.857, 0's: 0 Z-trim(118.7): 756  B-trim: 718 in 1/54
 Lambda= 0.045788
 statistics sampled from 31077 (31907) to 31077 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.697), E-opt: 0.2 (0.374), width:  16
 Scan time: 16.910

The best scores are:                                      opt bits E(85289)
NP_005415 (OMIM: 600222) tyrosine-protein kinase r (1138) 7895 539.0 6.1e-152
NP_001240286 (OMIM: 600222) tyrosine-protein kinas (1093) 7580 518.2 1.1e-145
XP_016857696 (OMIM: 600222) PREDICTED: tyrosine-pr ( 830) 5656 390.9 1.7e-107
XP_005271220 (OMIM: 600222) PREDICTED: tyrosine-pr (1095) 5566 385.1 1.2e-105
XP_006710932 (OMIM: 600222) PREDICTED: tyrosine-pr ( 783) 5269 365.3 8.1e-100
NP_001277007 (OMIM: 600195,600221) angiopoietin-1  ( 976) 1949 146.1 9.6e-34
XP_005251620 (OMIM: 600195,600221) PREDICTED: angi (1080) 1949 146.2   1e-33
NP_001277006 (OMIM: 600195,600221) angiopoietin-1  (1081) 1949 146.2   1e-33
XP_005251618 (OMIM: 600195,600221) PREDICTED: angi (1123) 1949 146.2   1e-33
NP_000450 (OMIM: 600195,600221) angiopoietin-1 rec (1124) 1949 146.2   1e-33
XP_016868719 (OMIM: 101600,123150,136350,147950,16 ( 498)  850 73.1 4.7e-12
NP_075254 (OMIM: 100800,109800,114500,134934,14600 ( 694)  852 73.5 5.1e-12
NP_000133 (OMIM: 100800,109800,114500,134934,14600 ( 806)  852 73.6 5.6e-12
XP_006713935 (OMIM: 100800,109800,114500,134934,14 ( 807)  852 73.6 5.6e-12
NP_001156685 (OMIM: 100800,109800,114500,134934,14 ( 808)  852 73.6 5.6e-12
XP_006713932 (OMIM: 100800,109800,114500,134934,14 ( 810)  852 73.6 5.6e-12
XP_016868717 (OMIM: 101600,123150,136350,147950,16 ( 729)  850 73.4 5.8e-12
NP_075594 (OMIM: 101600,123150,136350,147950,16625 ( 731)  850 73.4 5.8e-12
NP_001167537 (OMIM: 101600,123150,136350,147950,16 ( 733)  850 73.4 5.8e-12
NP_075593 (OMIM: 101600,123150,136350,147950,16625 ( 733)  850 73.4 5.8e-12
XP_006713936 (OMIM: 100800,109800,114500,134934,14 ( 807)  851 73.5 5.9e-12
XP_011511724 (OMIM: 100800,109800,114500,134934,14 ( 808)  851 73.5 5.9e-12
XP_011511722 (OMIM: 100800,109800,114500,134934,14 ( 809)  851 73.5 5.9e-12
XP_006713934 (OMIM: 100800,109800,114500,134934,14 ( 809)  851 73.5 5.9e-12
XP_006713933 (OMIM: 100800,109800,114500,134934,14 ( 810)  851 73.5 5.9e-12
XP_006713931 (OMIM: 100800,109800,114500,134934,14 ( 811)  851 73.5 5.9e-12
XP_016868716 (OMIM: 101600,123150,136350,147950,16 ( 762)  850 73.4   6e-12
XP_016868715 (OMIM: 101600,123150,136350,147950,16 ( 764)  850 73.4   6e-12
XP_011542752 (OMIM: 101600,123150,136350,147950,16 ( 764)  850 73.4   6e-12
NP_001167535 (OMIM: 101600,123150,136350,147950,16 ( 812)  850 73.4 6.2e-12
XP_016868713 (OMIM: 101600,123150,136350,147950,16 ( 818)  850 73.4 6.2e-12
XP_016868714 (OMIM: 101600,123150,136350,147950,16 ( 818)  850 73.4 6.2e-12
NP_001167536 (OMIM: 101600,123150,136350,147950,16 ( 820)  850 73.4 6.2e-12
NP_001167534 (OMIM: 101600,123150,136350,147950,16 ( 820)  850 73.4 6.2e-12
NP_056934 (OMIM: 101600,123150,136350,147950,16625 ( 820)  850 73.4 6.2e-12
NP_075598 (OMIM: 101600,123150,136350,147950,16625 ( 822)  850 73.4 6.2e-12
XP_016868709 (OMIM: 101600,123150,136350,147950,16 ( 851)  850 73.5 6.3e-12
NP_001167538 (OMIM: 101600,123150,136350,147950,16 ( 853)  850 73.5 6.3e-12
XP_011542749 (OMIM: 101600,123150,136350,147950,16 ( 853)  850 73.5 6.3e-12
XP_011542748 (OMIM: 101600,123150,136350,147950,16 ( 855)  850 73.5 6.4e-12
XP_016868718 (OMIM: 101600,123150,136350,147950,16 ( 508)  838 72.4 8.2e-12
XP_011542753 (OMIM: 101600,123150,136350,147950,16 ( 735)  838 72.6   1e-11
XP_006716377 (OMIM: 101600,123150,136350,147950,16 ( 741)  838 72.6   1e-11
XP_006716376 (OMIM: 101600,123150,136350,147950,16 ( 741)  838 72.6   1e-11
XP_006716373 (OMIM: 101600,123150,136350,147950,16 ( 743)  838 72.6   1e-11
XP_006716375 (OMIM: 101600,123150,136350,147950,16 ( 743)  838 72.6   1e-11
XP_006716374 (OMIM: 101600,123150,136350,147950,16 ( 743)  838 72.6   1e-11
XP_011542751 (OMIM: 101600,123150,136350,147950,16 ( 774)  838 72.6   1e-11
XP_011542750 (OMIM: 101600,123150,136350,147950,16 ( 776)  838 72.6   1e-11
XP_006716372 (OMIM: 101600,123150,136350,147950,16 ( 824)  838 72.7 1.1e-11


>>NP_005415 (OMIM: 600222) tyrosine-protein kinase recep  (1138 aa)
 initn: 7895 init1: 7895 opt: 7895  Z-score: 2848.9  bits: 539.0 E(85289): 6.1e-152
Smith-Waterman score: 7895; 100.0% identity (100.0% similar) in 1138 aa overlap (1-1138:1-1138)

               10        20        30        40        50        60
pF1KB9 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB9 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB9 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB9 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB9 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB9 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB9 LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB9 FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB9 INLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 INLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFA
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB9 SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWM
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB9 AIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDD
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130        
pF1KB9 EVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
             1090      1100      1110      1120      1130        

>>NP_001240286 (OMIM: 600222) tyrosine-protein kinase re  (1093 aa)
 initn: 7580 init1: 7580 opt: 7580  Z-score: 2736.6  bits: 518.2 E(85289): 1.1e-145
Smith-Waterman score: 7580; 100.0% identity (100.0% similar) in 1091 aa overlap (48-1138:3-1093)

        20        30        40        50        60        70       
pF1KB9 HVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPPLLLEKDDRIVRTPPGPP
                                     ::::::::::::::::::::::::::::::
NP_001                             MWAGAGRGSDAWGPPLLLEKDDRIVRTPPGPP
                                           10        20        30  

        80        90       100       110       120       130       
pF1KB9 LRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVN
             40        50        60        70        80        90  

       140       150       160       170       180       190       
pF1KB9 KGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATY
            100       110       120       130       140       150  

       200       210       220       230       240       250       
pF1KB9 LEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQ
            160       170       180       190       200       210  

       260       270       280       290       300       310       
pF1KB9 ACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRL
            220       230       240       250       260       270  

       320       330       340       350       360       370       
pF1KB9 QCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGN
            280       290       300       310       320       330  

       380       390       400       410       420       430       
pF1KB9 PFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSR
            340       350       360       370       380       390  

       440       450       460       470       480       490       
pF1KB9 RFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIV
            400       410       420       430       440       450  

       500       510       520       530       540       550       
pF1KB9 VDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVE
            460       470       480       490       500       510  

       560       570       580       590       600       610       
pF1KB9 GTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQ
            520       530       540       550       560       570  

       620       630       640       650       660       670       
pF1KB9 LDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKY
            580       590       600       610       620       630  

       680       690       700       710       720       730       
pF1KB9 VVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTL
            640       650       660       670       680       690  

       740       750       760       770       780       790       
pF1KB9 GNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTF
            700       710       720       730       740       750  

       800       810       820       830       840       850       
pF1KB9 TYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAM
            760       770       780       790       800       810  

       860       870       880       890       900       910       
pF1KB9 IKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAI
            820       830       840       850       860       870  

       920       930       940       950       960       970       
pF1KB9 EYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIH
            880       890       900       910       920       930  

       980       990      1000      1010      1020      1030       
pF1KB9 RDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVW
            940       950       960       970       980       990  

      1040      1050      1060      1070      1080      1090       
pF1KB9 SFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYER
           1000      1010      1020      1030      1040      1050  

      1100      1110      1120      1130        
pF1KB9 PPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
       :::::::::::::::::::::::::::::::::::::::::
NP_001 PPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
           1060      1070      1080      1090   

>>XP_016857696 (OMIM: 600222) PREDICTED: tyrosine-protei  (830 aa)
 initn: 5656 init1: 5656 opt: 5656  Z-score: 2050.9  bits: 390.9 E(85289): 1.7e-107
Smith-Waterman score: 5656; 100.0% identity (100.0% similar) in 803 aa overlap (1-803:1-803)

               10        20        30        40        50        60
pF1KB9 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB9 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB9 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB9 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB9 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB9 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB9 LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT
       :::::::::::::::::::::::                                     
XP_016 LTLVCIRRSCLHRRRTFTYQSGSAFLGSGASLCLHTSLADVLSPAVATCQ          
              790       800       810       820       830          

>>XP_005271220 (OMIM: 600222) PREDICTED: tyrosine-protei  (1095 aa)
 initn: 5324 init1: 5324 opt: 5566  Z-score: 2017.6  bits: 385.1 E(85289): 1.2e-105
Smith-Waterman score: 7438; 96.2% identity (96.2% similar) in 1138 aa overlap (1-1138:1-1095)

               10        20        30        40        50        60
pF1KB9 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL
       ::::                                           :::::::::::::
XP_005 QCQE-------------------------------------------DRIPQILNMASEL
                                                         310       

              370       380       390       400       410       420
pF1KB9 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
       320       330       340       350       360       370       

              430       440       450       460       470       480
pF1KB9 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
       380       390       400       410       420       430       

              490       500       510       520       530       540
pF1KB9 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
       440       450       460       470       480       490       

              550       560       570       580       590       600
pF1KB9 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
       500       510       520       530       540       550       

              610       620       630       640       650       660
pF1KB9 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
       560       570       580       590       600       610       

              670       680       690       700       710       720
pF1KB9 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
       620       630       640       650       660       670       

              730       740       750       760       770       780
pF1KB9 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
       680       690       700       710       720       730       

              790       800       810       820       830       840
pF1KB9 LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT
       740       750       760       770       780       790       

              850       860       870       880       890       900
pF1KB9 FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI
       800       810       820       830       840       850       

              910       920       930       940       950       960
pF1KB9 INLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 INLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFA
       860       870       880       890       900       910       

              970       980       990      1000      1010      1020
pF1KB9 SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWM
       920       930       940       950       960       970       

             1030      1040      1050      1060      1070      1080
pF1KB9 AIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDD
       980       990      1000      1010      1020      1030       

             1090      1100      1110      1120      1130        
pF1KB9 EVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
      1040      1050      1060      1070      1080      1090     

>>XP_006710932 (OMIM: 600222) PREDICTED: tyrosine-protei  (783 aa)
 initn: 5269 init1: 5269 opt: 5269  Z-score: 1913.0  bits: 365.3 E(85289): 8.1e-100
Smith-Waterman score: 5269; 100.0% identity (100.0% similar) in 783 aa overlap (356-1138:1-783)

         330       340       350       360       370       380     
pF1KB9 TCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSI
                                     ::::::::::::::::::::::::::::::
XP_006                               MASELEFNLETMPRINCAAAGNPFPVRGSI
                                             10        20        30

         390       400       410       420       430       440     
pF1KB9 ELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKV
               40        50        60        70        80        90

         450       460       470       480       490       500     
pF1KB9 PPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVT
              100       110       120       130       140       150

         510       520       530       540       550       560     
pF1KB9 LMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVS
              160       170       180       190       200       210

         570       580       590       600       610       620     
pF1KB9 WSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHC
              220       230       240       250       260       270

         630       640       650       660       670       680     
pF1KB9 TLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAG
              280       290       300       310       320       330

         690       700       710       720       730       740     
pF1KB9 GAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEG
              340       350       360       370       380       390

         750       760       770       780       790       800     
pF1KB9 PVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGE
              400       410       420       430       440       450

         810       820       830       840       850       860     
pF1KB9 ETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKM
              460       470       480       490       500       510

         870       880       890       900       910       920     
pF1KB9 NAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNL
              520       530       540       550       560       570

         930       940       950       960       970       980     
pF1KB9 LDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNV
              580       590       600       610       620       630

         990      1000      1010      1020      1030      1040     
pF1KB9 LVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWE
              640       650       660       670       680       690

        1050      1060      1070      1080      1090      1100     
pF1KB9 IVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIAL
              700       710       720       730       740       750

        1110      1120      1130        
pF1KB9 QLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
       :::::::::::::::::::::::::::::::::
XP_006 QLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
              760       770       780   

>>NP_001277007 (OMIM: 600195,600221) angiopoietin-1 rece  (976 aa)
 initn: 2804 init1: 1843 opt: 1949  Z-score: 726.8  bits: 146.1 E(85289): 9.6e-34
Smith-Waterman score: 2951; 47.7% identity (70.0% similar) in 1022 aa overlap (125-1138:18-975)

          100       110       120       130       140       150    
pF1KB9 KPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQT
                                     : .::  .: ::.:::.. .: .    :. 
NP_001              MDSLASLVLCGVSLLLSASFLPATLTMTVDKGDNVNISFKKVLIKEE
                            10        20        30        40       

          160       170       180       190       200       210    
pF1KB9 DVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRG
       :..  .:::.....  ::. :  . ..::..:: ..:.::: :. .. . ::: ::::: 
NP_001 DAVIYKNGSFIHSVPRHEVPDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRR
        50        60         70        80        90       100      

          220       230       240       250       260       270    
pF1KB9 CGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPG
       : : .::: :.. : .:...::::.  :::.::::: :  ::.::.   ::..:.:.: :
NP_001 CEAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSG
        110       120       130       140       150       160      

          280       290       300       310       320       330    
pF1KB9 ISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCV
         ::.. .:::::::::::..::.: ::.:.  :                    :..   
NP_001 QEGCKSYVFCLPDPYGCSCATGWKGLQCNEG-IP--------------------RMT---
        170       180       190                            200     

          340       350       360       370       380       390    
pF1KB9 CPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTV
                       :.:... ...: :   .  : : :.: :.:.   . : ::::::
NP_001 ----------------PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTV
                            210       220        230       240     

          400       410       420       430       440       450    
pF1KB9 LLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPR
       :         . ..: : . :..  ::: : : :.: .:.  . :...::: : :: :: 
NP_001 LHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPN
         250       260       270       280       290       300     

           460       470       480       490       500       510   
pF1KB9 LL-TKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKT
       .. : ..  ..      . :::::.. .: :.: .    :. : :  .: :::  :.:.:
NP_001 VIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRT
         310       320       330       340       350        360    

           520       530       540       550         560       570 
pF1KB9 GYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLV
        : . ::: : ::::::  ::   .::     .  :  .: ..  ..   : ..:. :. 
NP_001 EYELCVQLVRRGEGGEGHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIF
          370       380       390          400       410        420

             580       590       600        610       620       630
pF1KB9 PGPLVGDGFLLRLWDGTRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGP
       :.    : : ...   .  .  ..:.. :   :. ::..: :  .: . ... .    : 
NP_001 PSSE--DDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGE
                430       440       450       460       470        

               640       650       660       670        680        
pF1KB9 ASPPAHV-LLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAG
        :    .  :    :: :.... . .. :   ..:     : :  ::. ... .: :   
NP_001 WSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNE
       480       490       500       510          520       530    

      690       700         710       720       730       740      
pF1KB9 DPLWIDVDRPEETSTI--IRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGP
       :   .::   . : :   ..::.  : :   . :  ...:. :: .    : .  ....:
NP_001 DQH-VDVKIKNATITQYQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP
           540       550       560        570        580       590 

        750       760       770       780       790       800      
pF1KB9 VQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEE
             :. :  ..:..:..::.. ::::.: :.: .. ..:. ..:: . ..:.   ::
NP_001 ------ADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNR--EE
                   600       610       620       630       640     

        810       820       830       840       850       860      
pF1KB9 TILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMN
         .::.::::.:.:. : .:.:  ::::.:.:: :.:.:::::::::..: ::::::.:.
NP_001 PAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMD
           650       660       670       680       690       700   

        870       880       890       900       910       920      
pF1KB9 AAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLL
       :::: .:::::..::::::::::::::::::::::::::::..:::::.::::::.::::
NP_001 AAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLL
           710       720       730       740       750       760   

        930       940       950       960       970       980      
pF1KB9 DFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVL
       ::::::::::::::::  ..:::::::.:::.::.:.: ::.:::.::::::::::::.:
NP_001 DFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNIL
           770       780       790       800       810       820   

        990      1000      1010      1020      1030      1040      
pF1KB9 VGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEI
       :::: ..::::::::::.::::::::::::::::::::::::::::.:::::.:::::::
NP_001 VGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEI
           830       840       850       860       870       880   

       1050      1060      1070      1080      1090      1100      
pF1KB9 VSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQ
       :::::::::::::::::::::::::.:.: :::::::.:::::::..::::: :::: ..
NP_001 VSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVS
           890       900       910       920       930       940   

       1110      1120      1130         
pF1KB9 LGRMLEARKAYVNMSLFENFTYAGIDATAEEA 
       :.:::: ::.::: .:.:.::::::: .:::: 
NP_001 LNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
           950       960       970      

>>XP_005251620 (OMIM: 600195,600221) PREDICTED: angiopoi  (1080 aa)
 initn: 2804 init1: 1843 opt: 1949  Z-score: 726.3  bits: 146.2 E(85289): 1e-33
Smith-Waterman score: 3025; 45.0% identity (68.4% similar) in 1140 aa overlap (13-1138:14-1079)

                10        20        30        40        50         
pF1KB9  MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
                    :.:.. : .:.:: :. .: :..  .  :::...         .: :
XP_005 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
               10        20        30        40                 50 

        60        70        80            90       100       110   
pF1KB9 --PLLLEKDDRIVRTPPGPPLRLA----RNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
         :. . .: . . .    ::...    :. ...:. .   : : . :.. : : . .. 
XP_005 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
              60        70        80        90        100       110

           120       130       140       150       160       170   
pF1KB9 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
        :.  ..    : .::  .: ::.:::.. .: .    :. :..  .:::.....  ::.
XP_005 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
              120       130       140       150       160       170

           180       190       200       210       220       230   
pF1KB9 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
        :  . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
XP_005 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
               180       190       200       210       220         

           240       250       260       270       280       290   
pF1KB9 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
       .::::.  :::.::::: :  ::.::.   ::..:.:.: :  ::.. .:::::::::::
XP_005 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
     230       240       250       260       270       280         

           300       310       320       330       340       350   
pF1KB9 GSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQI
       ..::.: ::.:.           .:          :..                   :.:
XP_005 ATGWKGLQCNEG-----------IQ----------RMT-------------------PKI
     290       300                                                 

           360       370       380       390       400       410   
pF1KB9 LNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEV
       ... ...: :   .  : : :.: :.:.   . : :::::::         . ..: : .
XP_005 VDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTI
     310       320        330       340       350       360        

           420       430       440       450        460       470  
pF1KB9 PRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLVSFS
        :..  ::: : : :.: .:.  . :...::: : :: :: .. : ..  ..      . 
XP_005 HRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYF
      370       380       390       400       410       420        

            480       490       500       510       520       530  
pF1KB9 GDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAW
       :::::.. .: :.: .    :. : :  .: :::  :.:.: : . ::: : ::::::  
XP_005 GDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGEGHP
      430       440       450        460       470       480       

            540       550         560       570       580       590
pF1KB9 GPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRG
       ::   .::     .  :  .: ..  ..   : ..:. :. :.    : : ...   .  
XP_005 GPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERRSVQ
       490          500       510       520          530       540 

              600        610       620       630        640        
pF1KB9 QERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPPAPR
       .  ..:.. :   :. ::..: :  .: . ... .    :  :    .  :    :: :.
XP_005 KSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPPQPE
             550       560       570        580       590       600

      650       660       670        680       690       700       
pF1KB9 HLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETSTI--I
       ... . .. :   ..:     : :  ::. ... .: :   :   .::   . : :   .
XP_005 NIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQYQL
              610          620       630       640        650      

         710       720       730       740       750       760     
pF1KB9 RGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAV
       .::.  : :   . :  ...:. :: .    : .  ....:      :. :  ..:..:.
XP_005 KGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLLIAI
        660       670         680       690             700        

         770       780       790       800       810       820     
pF1KB9 VGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQ
       .::.. ::::.: :.: .. ..:. ..:: . ..:.   ::  .::.::::.:.:. : .
XP_005 LGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNR--EEPAVQFNSGTLALNRKVKNN
      710       720       730       740         750       760      

         830       840       850       860       870       880     
pF1KB9 PEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFA
       :.:  ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:::::..::::::
XP_005 PDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFA
        770       780       790       800       810       820      

         890       900       910       920       930       940     
pF1KB9 GELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREH
       ::::::::::::::::::::::..:::::.::::::.::::::::::::::::::::  .
XP_005 GELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIAN
        830       840       850       860       870       880      

         950       960       970       980       990      1000     
pF1KB9 GTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEE
       .:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..::::::::::.:
XP_005 STASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQE
        890       900       910       920       930       940      

        1010      1020      1030      1040      1050      1060     
pF1KB9 VYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEK
       :::::::::::::::::::::::::::.:::::.::::::::::::::::::::::::::
XP_005 VYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEK
        950       960       970       980       990      1000      

        1070      1080      1090      1100      1110      1120     
pF1KB9 LPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFEN
       ::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: ::.::: .:.:.
XP_005 LPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEK
       1010      1020      1030      1040      1050      1060      

        1130         
pF1KB9 FTYAGIDATAEEA 
       ::::::: .:::: 
XP_005 FTYAGIDCSAEEAA
       1070      1080

>>NP_001277006 (OMIM: 600195,600221) angiopoietin-1 rece  (1081 aa)
 initn: 2804 init1: 1843 opt: 1949  Z-score: 726.3  bits: 146.2 E(85289): 1e-33
Smith-Waterman score: 3025; 45.0% identity (68.3% similar) in 1140 aa overlap (13-1138:14-1080)

                10        20        30        40        50         
pF1KB9  MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
                    :.:.. : .:.:: :. .: :..  .  :::...         .: :
NP_001 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
               10        20        30        40                 50 

        60        70        80            90       100       110   
pF1KB9 --PLLLEKDDRIVRTPPGPPLRLA----RNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
         :. . .: . . .    ::...    :. ...:. .   : : . :.. : : . .. 
NP_001 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
              60        70        80        90        100       110

           120       130       140       150       160       170   
pF1KB9 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
        :.  ..    : .::  .: ::.:::.. .: .    :. :..  .:::.....  ::.
NP_001 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
              120       130       140       150       160       170

           180       190       200       210       220       230   
pF1KB9 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
        :  . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
NP_001 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
               180       190       200       210       220         

           240       250       260       270       280       290   
pF1KB9 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
       .::::.  :::.::::: :  ::.::.   ::..:.:.: :  ::.. .:::::::::::
NP_001 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
     230       240       250       260       270       280         

           300       310       320       330       340       350   
pF1KB9 GSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQI
       ..::.: ::.:.  :                    :..                   :.:
NP_001 ATGWKGLQCNEG-IP--------------------RMT-------------------PKI
     290       300                                                 

           360       370       380       390       400       410   
pF1KB9 LNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEV
       ... ...: :   .  : : :.: :.:.   . : :::::::         . ..: : .
NP_001 VDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTI
     310       320        330       340       350       360        

           420       430       440       450        460       470  
pF1KB9 PRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLVSFS
        :..  ::: : : :.: .:.  . :...::: : :: :: .. : ..  ..      . 
NP_001 HRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYF
      370       380       390       400       410       420        

            480       490       500       510       520       530  
pF1KB9 GDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAW
       :::::.. .: :.: .    :. : :  .: :::  :.:.: : . ::: : ::::::  
NP_001 GDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGEGHP
      430       440       450        460       470       480       

            540       550         560       570       580       590
pF1KB9 GPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRG
       ::   .::     .  :  .: ..  ..   : ..:. :. :.    : : ...   .  
NP_001 GPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERRSVQ
       490          500       510       520          530       540 

              600        610       620       630        640        
pF1KB9 QERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPPAPR
       .  ..:.. :   :. ::..: :  .: . ... .    :  :    .  :    :: :.
NP_001 KSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPPQPE
             550       560       570        580       590       600

      650       660       670        680       690       700       
pF1KB9 HLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETSTI--I
       ... . .. :   ..:     : :  ::. ... .: :   :   .::   . : :   .
NP_001 NIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQYQL
              610          620       630       640        650      

         710       720       730       740       750       760     
pF1KB9 RGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAV
       .::.  : :   . :  ...:. :: .    : .  ....:      :. :  ..:..:.
NP_001 KGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLLIAI
        660       670         680       690             700        

         770       780       790       800       810       820     
pF1KB9 VGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQ
       .::.. ::::.: :.: .. ..:. ..:: . ..:.   ::  .::.::::.:.:. : .
NP_001 LGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQN-VREEPAVQFNSGTLALNRKVKNN
      710       720       730       740        750       760       

         830       840       850       860       870       880     
pF1KB9 PEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFA
       :.:  ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:::::..::::::
NP_001 PDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFA
       770       780       790       800       810       820       

         890       900       910       920       930       940     
pF1KB9 GELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREH
       ::::::::::::::::::::::..:::::.::::::.::::::::::::::::::::  .
NP_001 GELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIAN
       830       840       850       860       870       880       

         950       960       970       980       990      1000     
pF1KB9 GTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEE
       .:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..::::::::::.:
NP_001 STASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQE
       890       900       910       920       930       940       

        1010      1020      1030      1040      1050      1060     
pF1KB9 VYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEK
       :::::::::::::::::::::::::::.:::::.::::::::::::::::::::::::::
NP_001 VYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEK
       950       960       970       980       990      1000       

        1070      1080      1090      1100      1110      1120     
pF1KB9 LPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFEN
       ::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: ::.::: .:.:.
NP_001 LPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEK
      1010      1020      1030      1040      1050      1060       

        1130         
pF1KB9 FTYAGIDATAEEA 
       ::::::: .:::: 
NP_001 FTYAGIDCSAEEAA
      1070      1080 

>>XP_005251618 (OMIM: 600195,600221) PREDICTED: angiopoi  (1123 aa)
 initn: 3040 init1: 1843 opt: 1949  Z-score: 726.2  bits: 146.2 E(85289): 1e-33
Smith-Waterman score: 3335; 46.9% identity (71.0% similar) in 1143 aa overlap (13-1138:14-1122)

                10        20        30        40        50         
pF1KB9  MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
                    :.:.. : .:.:: :. .: :..  .  :::...         .: :
XP_005 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
               10        20        30        40                 50 

        60        70        80            90       100       110   
pF1KB9 --PLLLEKDDRIVRTPPGPPLRLA----RNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
         :. . .: . . .    ::...    :. ...:. .   : : . :.. : : . .. 
XP_005 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
              60        70        80        90        100       110

           120       130       140       150       160       170   
pF1KB9 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
        :.  ..    : .::  .: ::.:::.. .: .    :. :..  .:::.....  ::.
XP_005 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
              120       130       140       150       160       170

           180       190       200       210       220       230   
pF1KB9 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
        :  . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
XP_005 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
               180       190       200       210       220         

           240       250       260       270       280       290   
pF1KB9 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
       .::::.  :::.::::: :  ::.::.   ::..:.:.: :  ::.. .:::::::::::
XP_005 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
     230       240       250       260       270       280         

           300       310       320       330       340         350 
pF1KB9 GSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKS--DRI-
       ..::.: ::.::: :: .: ::.:.:.:.::  ::::.::.:  ::.:..::.   .:. 
XP_005 ATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIQRMT
     290       300       310       320       330       340         

              360       370       380       390       400       410
pF1KB9 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAE
       :.:... ...: :   .  : : :.: :.:.   . : :::::::         . ..: 
XP_005 PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAI
     350       360        370       380       390       400        

              420       430       440       450        460         
pF1KB9 FEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLV
       : . :..  ::: : : :.: .:.  . :...::: : :: :: .. : ..  ..     
XP_005 FTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSE
      410       420       430       440       450       460        

     470       480       490       500       510       520         
pF1KB9 SFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGE
        . :::::.. .: :.: .    :. : :  .: :::  :.:.: : . ::: : :::::
XP_005 PYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGE
      470       480       490        500       510       520       

     530       540       550         560       570       580       
pF1KB9 GAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDG
       :  ::   .::     .  :  .: ..  ..   : ..:. :. :.    : : ...   
XP_005 GHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERR
       530          540       550       560        570         580 

       590       600        610       620       630        640     
pF1KB9 TRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPP
       .  .  ..:.. :   :. ::..: :  .: . ... .    :  :    .  :    ::
XP_005 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPP
             590       600       610        620       630       640

         650       660       670        680       690       700    
pF1KB9 APRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETSTI
        :.... . .. :   ..:     : :  ::. ... .: :   :   .::   . : : 
XP_005 QPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQ
              650       660          670       680        690      

            710       720       730       740       750       760  
pF1KB9 --IRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLI
         ..::.  : :   . :  ...:. :: .    : .  ....:      :. :  ..:.
XP_005 YQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLL
        700       710        720        730             740        

            770       780       790       800       810       820  
pF1KB9 LAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRP
       .:..::.. ::::.: :.: .. ..:. ..:: . ..:.   ::  .::.::::.:.:. 
XP_005 IAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNR--EEPAVQFNSGTLALNRKV
      750       760       770       780         790       800      

            830       840       850       860       870       880  
pF1KB9 KLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHR
       : .:.:  ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:::::..:::
XP_005 KNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHR
        810       820       830       840       850       860      

            890       900       910       920       930       940  
pF1KB9 DFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFA
       :::::::::::::::::::::::::..:::::.::::::.::::::::::::::::::::
XP_005 DFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFA
        870       880       890       900       910       920      

            950       960       970       980       990      1000  
pF1KB9 REHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR
         ..:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..:::::::::
XP_005 IANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR
        930       940       950       960       970       980      

           1010      1020      1030      1040      1050      1060  
pF1KB9 GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAEL
       :.::::::::::::::::::::::::::::.:::::.:::::::::::::::::::::::
XP_005 GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAEL
        990      1000      1010      1020      1030      1040      

           1070      1080      1090      1100      1110      1120  
pF1KB9 YEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSL
       :::::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: ::.::: .:
XP_005 YEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTL
       1050      1060      1070      1080      1090      1100      

           1130         
pF1KB9 FENFTYAGIDATAEEA 
       .:.::::::: .:::: 
XP_005 YEKFTYAGIDCSAEEAA
       1110      1120   

>>NP_000450 (OMIM: 600195,600221) angiopoietin-1 recepto  (1124 aa)
 initn: 3040 init1: 1843 opt: 1949  Z-score: 726.2  bits: 146.2 E(85289): 1e-33
Smith-Waterman score: 3334; 46.9% identity (71.0% similar) in 1143 aa overlap (13-1138:14-1123)

                10        20        30        40        50         
pF1KB9  MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
                    :.:.. : .:.:: :. .: :..  .  :::...         .: :
NP_000 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
               10        20        30        40                 50 

        60        70        80            90       100       110   
pF1KB9 --PLLLEKDDRIVRTPPGPPLRLA----RNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
         :. . .: . . .    ::...    :. ...:. .   : : . :.. : : . .. 
NP_000 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
              60        70        80        90        100       110

           120       130       140       150       160       170   
pF1KB9 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
        :.  ..    : .::  .: ::.:::.. .: .    :. :..  .:::.....  ::.
NP_000 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
              120       130       140       150       160       170

           180       190       200       210       220       230   
pF1KB9 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
        :  . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
NP_000 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
               180       190       200       210       220         

           240       250       260       270       280       290   
pF1KB9 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
       .::::.  :::.::::: :  ::.::.   ::..:.:.: :  ::.. .:::::::::::
NP_000 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
     230       240       250       260       270       280         

           300       310       320       330       340         350 
pF1KB9 GSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSD--RI-
       ..::.: ::.::: :: .: ::.:.:.:.::  ::::.::.:  ::.:..::.    :. 
NP_000 ATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMT
     290       300       310       320       330       340         

              360       370       380       390       400       410
pF1KB9 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAE
       :.:... ...: :   .  : : :.: :.:.   . : :::::::         . ..: 
NP_000 PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAI
     350       360        370       380       390       400        

              420       430       440       450        460         
pF1KB9 FEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLV
       : . :..  ::: : : :.: .:.  . :...::: : :: :: .. : ..  ..     
NP_000 FTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSE
      410       420       430       440       450       460        

     470       480       490       500       510       520         
pF1KB9 SFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGE
        . :::::.. .: :.: .    :. : :  .: :::  :.:.: : . ::: : :::::
NP_000 PYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGE
      470       480       490        500       510       520       

     530       540       550         560       570       580       
pF1KB9 GAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDG
       :  ::   .::     .  :  .: ..  ..   : ..:. :. :.    : : ...   
NP_000 GHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERR
       530          540       550       560        570         580 

       590       600        610       620       630        640     
pF1KB9 TRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPP
       .  .  ..:.. :   :. ::..: :  .: . ... .    :  :    .  :    ::
NP_000 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPP
             590       600       610        620       630       640

         650       660       670        680       690       700    
pF1KB9 APRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETSTI
        :.... . .. :   ..:     : :  ::. ... .: :   :   .::   . : : 
NP_000 QPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQ
              650       660          670       680        690      

            710       720       730       740       750       760  
pF1KB9 --IRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLI
         ..::.  : :   . :  ...:. :: .    : .  ....:      :. :  ..:.
NP_000 YQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLL
        700       710        720        730             740        

            770       780       790       800       810       820  
pF1KB9 LAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRP
       .:..::.. ::::.: :.: .. ..:. ..:: . ..:.   ::  .::.::::.:.:. 
NP_000 IAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQN-VREEPAVQFNSGTLALNRKV
      750       760       770       780        790       800       

            830       840       850       860       870       880  
pF1KB9 KLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHR
       : .:.:  ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:::::..:::
NP_000 KNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHR
       810       820       830       840       850       860       

            890       900       910       920       930       940  
pF1KB9 DFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFA
       :::::::::::::::::::::::::..:::::.::::::.::::::::::::::::::::
NP_000 DFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFA
       870       880       890       900       910       920       

            950       960       970       980       990      1000  
pF1KB9 REHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR
         ..:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..:::::::::
NP_000 IANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR
       930       940       950       960       970       980       

           1010      1020      1030      1040      1050      1060  
pF1KB9 GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAEL
       :.::::::::::::::::::::::::::::.:::::.:::::::::::::::::::::::
NP_000 GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAEL
       990      1000      1010      1020      1030      1040       

           1070      1080      1090      1100      1110      1120  
pF1KB9 YEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSL
       :::::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: ::.::: .:
NP_000 YEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTL
      1050      1060      1070      1080      1090      1100       

           1130         
pF1KB9 FENFTYAGIDATAEEA 
       .:.::::::: .:::: 
NP_000 YEKFTYAGIDCSAEEAA
      1110      1120    




1138 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 23:05:52 2016 done: Thu Nov  3 23:05:54 2016
 Total Scan time: 16.910 Total Display time:  0.500

Function used was FASTA [36.3.4 Apr, 2011]
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