Result of FASTA (omim) for pF1KB5444
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5444, 724 aa
  1>>>pF1KB5444 724 - 724 aa - 724 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 10.3321+/-0.000546; mu= -4.3164+/- 0.034
 mean_var=238.4826+/-48.892, 0's: 0 Z-trim(114.6): 25  B-trim: 748 in 2/52
 Lambda= 0.083051
 statistics sampled from 24514 (24537) to 24514 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.615), E-opt: 0.2 (0.288), width:  16
 Scan time: 12.370

The best scores are:                                      opt bits E(85289)
NP_031381 (OMIM: 140572) heat shock protein HSP 90 ( 724) 4664 572.8 1.6e-162
NP_001258899 (OMIM: 140572) heat shock protein HSP ( 724) 4664 572.8 1.6e-162
NP_001258898 (OMIM: 140572) heat shock protein HSP ( 724) 4664 572.8 1.6e-162
NP_005339 (OMIM: 140571) heat shock protein HSP 90 ( 732) 4122 507.9 5.8e-143
XP_011535020 (OMIM: 140571) PREDICTED: heat shock  ( 853) 4122 507.9 6.7e-143
NP_001017963 (OMIM: 140571) heat shock protein HSP ( 854) 4122 507.9 6.7e-143
NP_001258900 (OMIM: 140572) heat shock protein HSP ( 676) 3911 482.6 2.2e-135
NP_001258901 (OMIM: 140572) heat shock protein HSP ( 714) 3873 478.0 5.5e-134
NP_003290 (OMIM: 191175) endoplasmin precursor [Ho ( 803) 1823 232.4 5.3e-60
XP_011520647 (OMIM: 606219) PREDICTED: heat shock  ( 564)  628 89.2 4.9e-17
NP_001258978 (OMIM: 606219) heat shock protein 75  ( 651)  628 89.2 5.6e-17
NP_057376 (OMIM: 606219) heat shock protein 75 kDa ( 704)  628 89.2   6e-17
XP_016878340 (OMIM: 606219) PREDICTED: heat shock  ( 405)  592 84.8 7.4e-16


>>NP_031381 (OMIM: 140572) heat shock protein HSP 90-bet  (724 aa)
 initn: 4664 init1: 4664 opt: 4664  Z-score: 3038.6  bits: 572.8 E(85289): 1.6e-162
Smith-Waterman score: 4664; 100.0% identity (100.0% similar) in 724 aa overlap (1-724:1-724)

               10        20        30        40        50        60
pF1KB5 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB5 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB5 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB5 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB5 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
              670       680       690       700       710       720

           
pF1KB5 EEVD
       ::::
NP_031 EEVD
           

>>NP_001258899 (OMIM: 140572) heat shock protein HSP 90-  (724 aa)
 initn: 4664 init1: 4664 opt: 4664  Z-score: 3038.6  bits: 572.8 E(85289): 1.6e-162
Smith-Waterman score: 4664; 100.0% identity (100.0% similar) in 724 aa overlap (1-724:1-724)

               10        20        30        40        50        60
pF1KB5 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB5 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB5 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB5 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB5 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
              670       680       690       700       710       720

           
pF1KB5 EEVD
       ::::
NP_001 EEVD
           

>>NP_001258898 (OMIM: 140572) heat shock protein HSP 90-  (724 aa)
 initn: 4664 init1: 4664 opt: 4664  Z-score: 3038.6  bits: 572.8 E(85289): 1.6e-162
Smith-Waterman score: 4664; 100.0% identity (100.0% similar) in 724 aa overlap (1-724:1-724)

               10        20        30        40        50        60
pF1KB5 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB5 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB5 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB5 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB5 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
              670       680       690       700       710       720

           
pF1KB5 EEVD
       ::::
NP_001 EEVD
           

>>NP_005339 (OMIM: 140571) heat shock protein HSP 90-alp  (732 aa)
 initn: 2811 init1: 2811 opt: 4122  Z-score: 2687.6  bits: 507.9 E(85289): 5.8e-143
Smith-Waterman score: 4122; 85.8% identity (96.0% similar) in 732 aa overlap (1-724:1-732)

                    10        20        30        40        50     
pF1KB5 MPEEVHHG-----EEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIR
       ::::..       ::::::::::::::::::::::::::::::::::::::.::::::::
NP_005 MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIR
               10        20        30        40        50        60

          60        70        80        90       100       110     
pF1KB5 YESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFME
       ::::::::::::::::.:..::: :.::::.:::::::::::::::::::::::::::::
NP_005 YESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFME
               70        80        90       100       110       120

         120       130       140       150       160       170     
pF1KB5 ALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPI
       ::::::::::::::::::::::::::::.::::::::::::::::::::::::.: :::.
NP_005 ALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPM
              130       140       150       160       170       180

         180       190       200       210       220       230     
pF1KB5 GRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKG
       ::::::::::::::::::::::.::.::::::::::::::..::::.::.:::::::.. 
NP_005 GRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKED
              190       200       210       220       230       240

            240       250       260       270       280       290  
pF1KB5 ---EKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRN
          :::.:.:..:.::.:::::::::...    ::: :::::::::::::::::::::::
NP_005 KEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRN
              250       260       270       280       290       300

            300       310       320       330       340       350  
pF1KB5 PDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNN
       :::::.::::::::::::::::::::::::::::::::::::.:::::::::::.:::::
NP_005 PDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNN
              310       320       330       340       350       360

            360       370       380       390       400       410  
pF1KB5 IKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKC
       ::::::::::::.:.::::::::::::::::::::::::::::::::::::::::.::::
NP_005 IKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKC
              370       380       390       400       410       420

            420       430       440       450       460       470  
pF1KB5 LELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEY
       ::::.:::::::::::::: ::::.:::::::: ::..:::::::.:: :::::.::..:
NP_005 LELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDY
              430       440       450       460       470       480

            480       490       500       510       520       530  
pF1KB5 VSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKS
        .::::.:: :::::::.:.::::::::::.::.:.::.:: ::::::::::::::.::.
NP_005 CTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKT
              490       500       510       520       530       540

            540       550       560       570       580       590  
pF1KB5 LVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIV
       ::::::::::::::::::::.::.:.:::::::.::.::.::::::..:::::.::::::
NP_005 LVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIV
              550       560       570       580       590       600

            600       610       620       630       640       650  
pF1KB5 TSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVK
       :::::::::::::::::::::::::::: ::::::::::: :.::::::::::::::.::
NP_005 TSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVK
              610       620       630       640       650       660

            660       670       680       690       700       710  
pF1KB5 DLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLE
       :::.::.:::::::::::::::::.::::::::::::::::. .:.. .::: .:.::::
NP_005 DLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLE
              670       680       690       700       710       720

            720    
pF1KB5 GDEDASRMEEVD
       ::.:.:::::::
NP_005 GDDDTSRMEEVD
              730  

>>XP_011535020 (OMIM: 140571) PREDICTED: heat shock prot  (853 aa)
 initn: 2811 init1: 2811 opt: 4122  Z-score: 2686.5  bits: 507.9 E(85289): 6.7e-143
Smith-Waterman score: 4122; 85.8% identity (96.0% similar) in 732 aa overlap (1-724:122-853)

                                                  10        20     
pF1KB5                               MPEEVHHG-----EEEVETFAFQAEIAQLM
                                     ::::..       :::::::::::::::::
XP_011 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
             100       110       120       130       140       150 

          30        40        50        60        70        80     
pF1KB5 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLT
       :::::::::::::::::::::.::::::::::::::::::::::::.:..::: :.::::
XP_011 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
             160       170       180       190       200       210 

          90       100       110       120       130       140     
pF1KB5 LVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVV
       .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_011 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
             220       230       240       250       260       270 

         150       160       170       180       190       200     
pF1KB5 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH
       :::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.::::
XP_011 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
             280       290       300       310       320       330 

         210       220       230          240       250       260  
pF1KB5 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG
       ::::::::::..::::.::.:::::::..    :::.:.:..:.::.:::::::::... 
XP_011 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
             340       350       360       370       380       390 

            270       280       290       300       310       320  
pF1KB5 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS
          ::: ::::::::::::::::::::::::::::.::::::::::::::::::::::::
XP_011 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
             400       410       420       430       440       450 

            330       340       350       360       370       380  
pF1KB5 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD
       ::::::::::::.:::::::::::.:::::::::::::::::.:.:::::::::::::::
XP_011 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
             460       470       480       490       500       510 

            390       400       410       420       430       440  
pF1KB5 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH
       :::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.:::::
XP_011 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
             520       530       540       550       560       570 

            450       460       470       480       490       500  
pF1KB5 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER
       ::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.::::::::::
XP_011 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
             580       590       600       610       620       630 

            510       520       530       540       550       560  
pF1KB5 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN
       .::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.::::
XP_011 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
             640       650       660       670       680       690 

            570       580       590       600       610       620  
pF1KB5 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA
       :::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: :
XP_011 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
             700       710       720       730       740       750 

            630       640       650       660       670       680  
pF1KB5 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
       :::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.:::::
XP_011 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
             760       770       780       790       800       810 

            690       700       710       720    
pF1KB5 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
       :::::::::::. .:.. .::: .:.::::::.:.:::::::
XP_011 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
             820       830       840       850   

>>NP_001017963 (OMIM: 140571) heat shock protein HSP 90-  (854 aa)
 initn: 2811 init1: 2811 opt: 4122  Z-score: 2686.5  bits: 507.9 E(85289): 6.7e-143
Smith-Waterman score: 4122; 85.8% identity (96.0% similar) in 732 aa overlap (1-724:123-854)

                                                  10        20     
pF1KB5                               MPEEVHHG-----EEEVETFAFQAEIAQLM
                                     ::::..       :::::::::::::::::
NP_001 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
            100       110       120       130       140       150  

          30        40        50        60        70        80     
pF1KB5 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLT
       :::::::::::::::::::::.::::::::::::::::::::::::.:..::: :.::::
NP_001 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
            160       170       180       190       200       210  

          90       100       110       120       130       140     
pF1KB5 LVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVV
       .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_001 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
            220       230       240       250       260       270  

         150       160       170       180       190       200     
pF1KB5 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH
       :::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.::::
NP_001 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
            280       290       300       310       320       330  

         210       220       230          240       250       260  
pF1KB5 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG
       ::::::::::..::::.::.:::::::..    :::.:.:..:.::.:::::::::... 
NP_001 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
            340       350       360       370       380       390  

            270       280       290       300       310       320  
pF1KB5 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS
          ::: ::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_001 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
            400       410       420       430       440       450  

            330       340       350       360       370       380  
pF1KB5 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD
       ::::::::::::.:::::::::::.:::::::::::::::::.:.:::::::::::::::
NP_001 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
            460       470       480       490       500       510  

            390       400       410       420       430       440  
pF1KB5 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH
       :::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.:::::
NP_001 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
            520       530       540       550       560       570  

            450       460       470       480       490       500  
pF1KB5 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER
       ::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.::::::::::
NP_001 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
            580       590       600       610       620       630  

            510       520       530       540       550       560  
pF1KB5 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN
       .::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.::::
NP_001 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
            640       650       660       670       680       690  

            570       580       590       600       610       620  
pF1KB5 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA
       :::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: :
NP_001 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
            700       710       720       730       740       750  

            630       640       650       660       670       680  
pF1KB5 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
       :::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.:::::
NP_001 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
            760       770       780       790       800       810  

            690       700       710       720    
pF1KB5 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
       :::::::::::. .:.. .::: .:.::::::.:.:::::::
NP_001 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
            820       830       840       850    

>>NP_001258900 (OMIM: 140572) heat shock protein HSP 90-  (676 aa)
 initn: 3911 init1: 3911 opt: 3911  Z-score: 2551.5  bits: 482.6 E(85289): 2.2e-135
Smith-Waterman score: 4260; 93.4% identity (93.4% similar) in 724 aa overlap (1-724:1-676)

               10        20        30        40        50        60
pF1KB5 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
       :::::::::::::::                                             
NP_001 DPSKLDSGKELKIDI---------------------------------------------
               70                                                  

              130       140       150       160       170       180
pF1KB5 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
          :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ---SMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
             80        90       100       110       120       130  

              190       200       210       220       230       240
pF1KB5 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
            140       150       160       170       180       190  

              250       260       270       280       290       300
pF1KB5 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
            200       210       220       230       240       250  

              310       320       330       340       350       360
pF1KB5 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
            260       270       280       290       300       310  

              370       380       390       400       410       420
pF1KB5 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
            320       330       340       350       360       370  

              430       440       450       460       470       480
pF1KB5 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
            380       390       400       410       420       430  

              490       500       510       520       530       540
pF1KB5 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
            440       450       460       470       480       490  

              550       560       570       580       590       600
pF1KB5 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
            500       510       520       530       540       550  

              610       620       630       640       650       660
pF1KB5 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
            560       570       580       590       600       610  

              670       680       690       700       710       720
pF1KB5 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
            620       630       640       650       660       670  

           
pF1KB5 EEVD
       ::::
NP_001 EEVD
           

>>NP_001258901 (OMIM: 140572) heat shock protein HSP 90-  (714 aa)
 initn: 3873 init1: 3873 opt: 3873  Z-score: 2526.5  bits: 478.0 E(85289): 5.5e-134
Smith-Waterman score: 4571; 98.6% identity (98.6% similar) in 724 aa overlap (1-724:1-714)

               10        20        30        40        50        60
pF1KB5 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::  
NP_001 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQ--
               70        80        90       100       110          

              130       140       150       160       170       180
pF1KB5 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
               ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 --------FGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
              120       130       140       150       160       170

              190       200       210       220       230       240
pF1KB5 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
              180       190       200       210       220       230

              250       260       270       280       290       300
pF1KB5 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
              240       250       260       270       280       290

              310       320       330       340       350       360
pF1KB5 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
              300       310       320       330       340       350

              370       380       390       400       410       420
pF1KB5 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
              360       370       380       390       400       410

              430       440       450       460       470       480
pF1KB5 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
              420       430       440       450       460       470

              490       500       510       520       530       540
pF1KB5 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
              480       490       500       510       520       530

              550       560       570       580       590       600
pF1KB5 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
              540       550       560       570       580       590

              610       620       630       640       650       660
pF1KB5 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
              600       610       620       630       640       650

              670       680       690       700       710       720
pF1KB5 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
              660       670       680       690       700       710

           
pF1KB5 EEVD
       ::::
NP_001 EEVD
           

>>NP_003290 (OMIM: 191175) endoplasmin precursor [Homo s  (803 aa)
 initn: 1677 init1: 447 opt: 1823  Z-score: 1198.2  bits: 232.4 E(85289): 5.3e-60
Smith-Waterman score: 2207; 47.8% identity (75.7% similar) in 737 aa overlap (4-724:65-783)

                                          10        20        30   
pF1KB5                            MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFY
                                     .... .:. : ::::::. ..:.::::..:
NP_003 LGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLY
           40        50        60        70        80        90    

            40        50        60        70        80        90   
pF1KB5 SNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGM
       .:::::::::::::::::::::  :::: . :....:: . :  . ..  : ..:::.::
NP_003 KNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGM
          100       110       120       130       140       150    

           100       110           120        130       140        
pF1KB5 TKADLINNLGTIAKSGTKAFM----EALQAGADIS-MIGQFGVGFYSAYLVAEKVVVITK
       :. .:..::::::::::. :.    :: . : . : .:::::::::::.:::.::.: .:
NP_003 TREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSK
          160       170       180       190       200       210    

      150       160       170        180       190       200       
pF1KB5 HNDDEQYAWESSAGGSFTVRAD-HGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQ
       ::.: :. :::...  :.: :: .:. .:::: . : :::. ..:::   .:..:::.::
NP_003 HNNDTQHIWESDSN-EFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQ
          220        230       240       250       260       270   

       210       220       230       240       250       260       
pF1KB5 FIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKK
       ::..::  :. . . . . .   ::: ...:.:..:::       .. .::..   .:: 
NP_003 FINFPI--YVWSSKTETVEEPMEEEEAAKEEKEESDDE-------AAVEEEEE---EKKP
             280       290       300              310          320 

       270       280       290       300       310       320       
pF1KB5 KTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQL
       ::::...   : : .:  :::: :   .. ..::  ::::.... .: .:  ::..::..
NP_003 KTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEV
             330       340       350       360       370       380 

       330       340         350       360       370       380     
pF1KB5 EFRALLFIPRRAPFDLFEN--KKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSED
        :...::.:  ::  ::..  .::.. :::::::::: :.  ...:.::::..:::::.:
NP_003 TFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDD
             390       400       410       420       430       440 

         390       400       410       420       430       440     
pF1KB5 LPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDS
       ::::.::: ::: :.::::::..:.: :......:.:: :   :.. :. :.:::. :: 
NP_003 LPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYN-DTFWKEFGTNIKLGVIEDH
             450       460       470       480        490       500

         450       460       470       480       490       500     
pF1KB5 TNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRK
       .:: ::..:::...:.   ..:::..:: :::: : .::...: :.... .: ::::. :
NP_003 SNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLK
              510       520       530       540       550       560

         510       520       530       540       550       560     
pF1KB5 RGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCK
       .:.::.:.:::.::::.: : ::::: . .:.:::... :.:. :.. :  . .:: : .
NP_003 KGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLN
              570       580       590       600       610       620

          570       580       590       600       610          620 
pF1KB5 LMKE-ILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQAL---RDNSTMGYMM
        ::.  :  :.::...:.::. ::: .:.: :::..::::::::::    .: ::  :  
NP_003 WMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYAS
              630       640       650       660       670       680

             630       640       650       660       670       680 
pF1KB5 AKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIY
        :: .:::: ::... . .. . :..::.: ::.:.::::: : ::. : : .....:: 
NP_003 QKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIE
              690       700       710       720       730       740

             690           700       710       720                 
pF1KB5 RMIKLGLGIDED----EVAAEEPNAAVPDEIPPLEGDEDASRMEEVD             
       ::..:.:.:: :    :   :::. .. :     : :::    ::.:             
NP_003 RMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDED----EEMDVGTDEEEETAKES
              750       760       770           780       790      

NP_003 TAEKDEL
        800   

>>XP_011520647 (OMIM: 606219) PREDICTED: heat shock prot  (564 aa)
 initn: 736 init1: 289 opt: 628  Z-score: 426.8  bits: 89.2 E(85289): 4.9e-17
Smith-Waterman score: 960; 29.9% identity (61.7% similar) in 629 aa overlap (71-684:1-557)

               50        60        70        80        90       100
pF1KB5 RELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLIN
                                     ..: .  : .. :.:. :::::::. .:..
XP_011                               MEIHLQTNAEKGTITIQDTGIGMTQEELVS
                                             10        20        30

              110       120         130       140       150        
pF1KB5 NLGTIAKSGTKAFMEALQAGADIS--MIGQFGVGFYSAYLVAEKVVVITKHNDDEQ--YA
       ::::::.::.:::..:::  :. :  .:::::::::::..::..: : ..     .  : 
XP_011 NLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQ
               40        50        60        70        80        90

        160       170       180       190       200       210      
pF1KB5 WESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLY
       : :...: : .    :  .  :::.:.::: :  :.  : ::..:: :.:.:...:  ::
XP_011 WLSDGSGVFEIAEASG--VRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFP--LY
              100         110       120       130       140        

        220       230       240       250       260       270      
pF1KB5 LEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKY
       :. .:                                                       
XP_011 LNGRR-------------------------------------------------------
        150                                                        

        280       290       300       310       320       330      
pF1KB5 IDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIP
            .:  . ::  .: :. . .. :::. ...  .    . :..... :..:.....:
XP_011 -----MNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVP
                  160       170       180       190       200      

        340        350       360       370       380       390     
pF1KB5 RRAPFDLFE-NKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREML
          : ..:. ...  ... :: :.:.:. .  ...:..: ::::::::::.:::.:::.:
XP_011 DMKP-SMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELL
        210        220       230       240       250       260     

         400       410       420        430       440         450  
pF1KB5 QQSKILKVIRKNIVKKCLELFSELAE-DKENYKKFYEAFSKNLKLGI--HEDSTNRRRLS
       :.: ... .:  . .. ...: . .. : :.: ::.: ..  .. ::    ..  .. ..
XP_011 QESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIA
         270       280       290       300       310       320     

            460         470       480       490       500       510
pF1KB5 ELLRYHTSQ--SGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEV
       .::::..:   :: ..::::::.:::.   ..:::. . ... . .: . : ..:.  ::
XP_011 KLLRYESSALPSG-QLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEV
         330        340       350       360       370       380    

              520       530       540          550         560     
pF1KB5 VYMTEPIDEYCVQQLKEFDGKSLVSVTKEGL--ELPEDE-EEKKKMEE--SKAKFENLCK
       ..  : .::  . .:.::: :.:.::  . .  .  :.. :...   :  :. . :.:  
XP_011 LFCFEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMA
          390       400       410       420       430       440    

         570       580       590       600       610       620     
pF1KB5 LMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKH
        :...: ..: .: .. :: . :  ...  .:     ..... : :  ..    .. .  
XP_011 WMRNVLGSRVTNVKVTLRLDTHPAMVTVLEMG---AARHFLRMQQLAKTQEERAQLLQPT
          450       460       470          480       490       500 

         630       640       650       660       670       680     
pF1KB5 LEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIK
       ::::: : ... : :   .. .   .. ::  ..:.:....:. ..::..  .:. ... 
XP_011 LEINPRHALIKKLNQLRASEPG--LAQLLVDQIYENAMIAAGL-VDDPRAMVGRLNELLV
             510       520         530       540        550        

         690       700       710       720    
pF1KB5 LGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
                                              
XP_011 KALERH                                 
      560                                     




724 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 22:32:37 2016 done: Thu Nov  3 22:32:38 2016
 Total Scan time: 12.370 Total Display time:  0.240

Function used was FASTA [36.3.4 Apr, 2011]
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