Result of FASTA (omim) for pF1KB3244
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3244, 2162 aa
  1>>>pF1KB3244 2162 - 2162 aa - 2162 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.4512+/-0.000527; mu= 5.2020+/- 0.032
 mean_var=227.3942+/-47.073, 0's: 0 Z-trim(115.3): 45  B-trim: 0 in 0/54
 Lambda= 0.085052
 statistics sampled from 25597 (25633) to 25597 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.301), width:  16
 Scan time: 19.400

The best scores are:                                      opt bits E(85289)
NP_001293008 (OMIM: 114010,616457) CAD protein iso (2162) 14382 1779.9       0
XP_006712164 (OMIM: 114010,616457) PREDICTED: CAD  (2179) 12026 1490.8       0
NP_004332 (OMIM: 114010,616457) CAD protein isofor (2225) 10262 1274.4       0
XP_005264612 (OMIM: 114010,616457) PREDICTED: CAD  (2242) 7906 985.3       0
NP_001116106 (OMIM: 237300,608307,615371) carbamoy (1049) 2170 281.2 4.2e-74
XP_011508945 (OMIM: 237300,608307,615371) PREDICTE (1500) 2170 281.3 5.6e-74
XP_011508946 (OMIM: 237300,608307,615371) PREDICTE (1500) 2170 281.3 5.6e-74
XP_011508943 (OMIM: 237300,608307,615371) PREDICTE (1500) 2170 281.3 5.6e-74
XP_011508944 (OMIM: 237300,608307,615371) PREDICTE (1500) 2170 281.3 5.6e-74
NP_001866 (OMIM: 237300,608307,615371) carbamoyl-p (1500) 2170 281.3 5.6e-74
NP_001116105 (OMIM: 237300,608307,615371) carbamoy (1506) 2170 281.3 5.6e-74
XP_011508942 (OMIM: 237300,608307,615371) PREDICTE (1511) 2170 281.3 5.6e-74
NP_000522 (OMIM: 300461,311250) ornithine carbamoy ( 354)  333 55.5 1.3e-06
XP_016885045 (OMIM: 300461,311250) PREDICTED: orni ( 311)  272 48.0  0.0002


>>NP_001293008 (OMIM: 114010,616457) CAD protein isoform  (2162 aa)
 initn: 14382 init1: 14382 opt: 14382  Z-score: 9545.2  bits: 1779.9 E(85289):    0
Smith-Waterman score: 14382; 100.0% identity (100.0% similar) in 2162 aa overlap (1-2162:1-2162)

               10        20        30        40        50        60
pF1KB3 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 GIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 TRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 LDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 SEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 TDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 TAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAI
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 KALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQT
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 ALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 AQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEI
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 EYEVVRDAYGNCVTYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYEVVRDAYGNCVTYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVT
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 GGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMV
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 DENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRI
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 IAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQI
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 DTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLR
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 KMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNM
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 AMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGY
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 PCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASD
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB3 GVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQL
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB3 IAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKV
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB3 PQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYK
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KB3 NKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQ
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KB3 LAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQI
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KB3 GPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAM
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KB3 PNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETF
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KB3 SELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILL
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KB3 IKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCF
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KB3 ASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLP
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KB3 PQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPP
             1690      1700      1710      1720      1730      1740

             1750      1760      1770      1780      1790      1800
pF1KB3 GYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGL
             1750      1760      1770      1780      1790      1800

             1810      1820      1830      1840      1850      1860
pF1KB3 PAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSLVG
             1810      1820      1830      1840      1850      1860

             1870      1880      1890      1900      1910      1920
pF1KB3 QHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAAA
             1870      1880      1890      1900      1910      1920

             1930      1940      1950      1960      1970      1980
pF1KB3 MARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRPVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRPVI
             1930      1940      1950      1960      1970      1980

             1990      2000      2010      2020      2030      2040
pF1KB3 NAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSLRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSLRY
             1990      2000      2010      2020      2030      2040

             2050      2060      2070      2080      2090      2100
pF1KB3 VAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEACFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEACFG
             2050      2060      2070      2080      2090      2100

             2110      2120      2130      2140      2150      2160
pF1KB3 QFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLG
             2110      2120      2130      2140      2150      2160

         
pF1KB3 RF
       ::
NP_001 RF
         

>>XP_006712164 (OMIM: 114010,616457) PREDICTED: CAD prot  (2179 aa)
 initn: 12018 init1: 12018 opt: 12026  Z-score: 7982.8  bits: 1490.8 E(85289):    0
Smith-Waterman score: 14338; 99.2% identity (99.2% similar) in 2179 aa overlap (1-2162:1-2179)

               10        20        30        40        50        60
pF1KB3 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 GIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 TRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 LDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 SEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 TDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 TAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAI
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 KALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQT
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 ALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 AQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEI
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 EYEVVRDAYGNCVTYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EYEVVRDAYGNCVTYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVT
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 GGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMV
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 DENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRI
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 IAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQI
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 DTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLR
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 KMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNM
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 AMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGY
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 PCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASD
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB3 GVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQL
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB3 IAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKV
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB3 PQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYK
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KB3 NKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQ
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KB3 LAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQI
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KB3 GPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAM
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KB3 PNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETF
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KB3 SELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILL
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KB3 IKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCF
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KB3 ASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLP
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KB3 PQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPP
             1690      1700      1710      1720      1730      1740

             1750      1760      1770      1780      1790      1800
pF1KB3 GYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGL
             1750      1760      1770      1780      1790      1800

                              1810      1820      1830      1840   
pF1KB3 PA-----------------EEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGT
       ::                 :::::::::::::::::::::::::::::::::::::::::
XP_006 PAVFLRPGAGIPRGSRAWAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGT
             1810      1820      1830      1840      1850      1860

          1850      1860      1870      1880      1890      1900   
pF1KB3 PGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMA
             1870      1880      1890      1900      1910      1920

          1910      1920      1930      1940      1950      1960   
pF1KB3 SMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHP
             1930      1940      1950      1960      1970      1980

          1970      1980      1990      2000      2010      2020   
pF1KB3 QPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRT
             1990      2000      2010      2020      2030      2040

          2030      2040      2050      2060      2070      2080   
pF1KB3 VHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTR
             2050      2060      2070      2080      2090      2100

          2090      2100      2110      2120      2130      2140   
pF1KB3 IQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQ
             2110      2120      2130      2140      2150      2160

          2150      2160  
pF1KB3 AENGMYIRMALLATVLGRF
       :::::::::::::::::::
XP_006 AENGMYIRMALLATVLGRF
             2170         

>>NP_004332 (OMIM: 114010,616457) CAD protein isoform 1   (2225 aa)
 initn: 10262 init1: 10262 opt: 10262  Z-score: 6812.8  bits: 1274.4 E(85289):    0
Smith-Waterman score: 14055; 97.1% identity (97.1% similar) in 2194 aa overlap (32-2162:32-2225)

              10        20        30        40        50        60 
pF1KB3 AALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYG
                                     ::::::::::::::::::::::::::::::
NP_004 AALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYG
              10        20        30        40        50        60 

              70        80        90       100       110       120 
pF1KB3 IPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDT
              70        80        90       100       110       120 

             130       140       150       160       170       180 
pF1KB3 RELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILAL
             130       140       150       160       170       180 

             190       200       210       220       230       240 
pF1KB3 DCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLS
             190       200       210       220       230       240 

             250       260       270       280       290       300 
pF1KB3 EPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVET
             250       260       270       280       290       300 

             310       320       330       340       350       360 
pF1KB3 DSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEAT
             310       320       330       340       350       360 

             370       380       390       400       410       420 
pF1KB3 AGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIK
             370       380       390       400       410       420 

             430       440       450       460       470       480 
pF1KB3 ALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTA
             430       440       450       460       470       480 

             490       500       510       520       530       540 
pF1KB3 LNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQA
             490       500       510       520       530       540 

             550       560       570       580       590       600 
pF1KB3 QAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIE
             550       560       570       580       590       600 

             610                                                   
pF1KB3 YEVVRDAYGNCVT-----------------------------------------------
       :::::::::::::                                               
NP_004 YEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLGI
             610       620       630       640       650       660 

                          620       630       640       650        
pF1KB3 ----------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNS
                       ::::::::::::::::::::::::::::::::::::::::::::
NP_004 VGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNS
             670       680       690       700       710       720 

      660       670       680       690       700       710        
pF1KB3 VTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALR
             730       740       750       760       770       780 

      720       730       740       750       760       770        
pF1KB3 MVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMK
             790       800       810       820       830       840 

      780       790       800       810       820       830        
pF1KB3 RIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVK
             850       860       870       880       890       900 

      840       850       860       870       880       890        
pF1KB3 QIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQ
             910       920       930       940       950       960 

      900       910       920       930       940       950        
pF1KB3 LRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPN
             970       980       990      1000      1010      1020 

      960       970       980       990      1000      1010        
pF1KB3 NMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTV
            1030      1040      1050      1060      1070      1080 

     1020      1030      1040      1050      1060      1070        
pF1KB3 GYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVA
            1090      1100      1110      1120      1130      1140 

     1080      1090      1100      1110      1120      1130        
pF1KB3 SDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNL
            1150      1160      1170      1180      1190      1200 

     1140      1150      1160      1170      1180      1190        
pF1KB3 QLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGV
            1210      1220      1230      1240      1250      1260 

     1200      1210      1220      1230      1240      1250        
pF1KB3 KVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGS
            1270      1280      1290      1300      1310      1320 

     1260      1270      1280      1290      1300      1310        
pF1KB3 YKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSIL
            1330      1340      1350      1360      1370      1380 

     1320      1330      1340      1350      1360      1370        
pF1KB3 EQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALG
            1390      1400      1410      1420      1430      1440 

     1380      1390      1400      1410      1420      1430        
pF1KB3 QIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVC
            1450      1460      1470      1480      1490      1500 

     1440      1450      1460      1470      1480      1490        
pF1KB3 AMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNE
            1510      1520      1530      1540      1550      1560 

     1500      1510      1520      1530      1540      1550        
pF1KB3 TFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEI
            1570      1580      1590      1600      1610      1620 

     1560      1570      1580      1590      1600      1610        
pF1KB3 LLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVID
            1630      1640      1650      1660      1670      1680 

     1620      1630      1640      1650      1660      1670        
pF1KB3 CFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFH
            1690      1700      1710      1720      1730      1740 

     1680      1690      1700      1710      1720      1730        
pF1KB3 LPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLV
            1750      1760      1770      1780      1790      1800 

     1740      1750      1760      1770      1780      1790        
pF1KB3 PPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDP
            1810      1820      1830      1840      1850      1860 

     1800      1810      1820      1830      1840      1850        
pF1KB3 GLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSL
            1870      1880      1890      1900      1910      1920 

     1860      1870      1880      1890      1900      1910        
pF1KB3 VGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFA
            1930      1940      1950      1960      1970      1980 

     1920      1930      1940      1950      1960      1970        
pF1KB3 AAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRP
            1990      2000      2010      2020      2030      2040 

     1980      1990      2000      2010      2020      2030        
pF1KB3 VINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSL
            2050      2060      2070      2080      2090      2100 

     2040      2050      2060      2070      2080      2090        
pF1KB3 RYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEAC
            2110      2120      2130      2140      2150      2160 

     2100      2110      2120      2130      2140      2150        
pF1KB3 FGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATV
            2170      2180      2190      2200      2210      2220 

     2160  
pF1KB3 LGRF
       ::::
NP_004 LGRF
           

>>XP_005264612 (OMIM: 114010,616457) PREDICTED: CAD prot  (2242 aa)
 initn: 7898 init1: 7898 opt: 7906  Z-score: 5250.4  bits: 985.3 E(85289):    0
Smith-Waterman score: 14011; 96.4% identity (96.4% similar) in 2211 aa overlap (32-2162:32-2242)

              10        20        30        40        50        60 
pF1KB3 AALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYG
                                     ::::::::::::::::::::::::::::::
XP_005 AALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYG
              10        20        30        40        50        60 

              70        80        90       100       110       120 
pF1KB3 IPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDT
              70        80        90       100       110       120 

             130       140       150       160       170       180 
pF1KB3 RELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILAL
             130       140       150       160       170       180 

             190       200       210       220       230       240 
pF1KB3 DCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLS
             190       200       210       220       230       240 

             250       260       270       280       290       300 
pF1KB3 EPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVET
             250       260       270       280       290       300 

             310       320       330       340       350       360 
pF1KB3 DSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEAT
             310       320       330       340       350       360 

             370       380       390       400       410       420 
pF1KB3 AGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIK
             370       380       390       400       410       420 

             430       440       450       460       470       480 
pF1KB3 ALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTA
             430       440       450       460       470       480 

             490       500       510       520       530       540 
pF1KB3 LNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQA
             490       500       510       520       530       540 

             550       560       570       580       590       600 
pF1KB3 QAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIE
             550       560       570       580       590       600 

             610                                                   
pF1KB3 YEVVRDAYGNCVT-----------------------------------------------
       :::::::::::::                                               
XP_005 YEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLGI
             610       620       630       640       650       660 

                          620       630       640       650        
pF1KB3 ----------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNS
                       ::::::::::::::::::::::::::::::::::::::::::::
XP_005 VGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNS
             670       680       690       700       710       720 

      660       670       680       690       700       710        
pF1KB3 VTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALR
             730       740       750       760       770       780 

      720       730       740       750       760       770        
pF1KB3 MVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMK
             790       800       810       820       830       840 

      780       790       800       810       820       830        
pF1KB3 RIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVK
             850       860       870       880       890       900 

      840       850       860       870       880       890        
pF1KB3 QIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQ
             910       920       930       940       950       960 

      900       910       920       930       940       950        
pF1KB3 LRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPN
             970       980       990      1000      1010      1020 

      960       970       980       990      1000      1010        
pF1KB3 NMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTV
            1030      1040      1050      1060      1070      1080 

     1020      1030      1040      1050      1060      1070        
pF1KB3 GYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVA
            1090      1100      1110      1120      1130      1140 

     1080      1090      1100      1110      1120      1130        
pF1KB3 SDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNL
            1150      1160      1170      1180      1190      1200 

     1140      1150      1160      1170      1180      1190        
pF1KB3 QLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGV
            1210      1220      1230      1240      1250      1260 

     1200      1210      1220      1230      1240      1250        
pF1KB3 KVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGS
            1270      1280      1290      1300      1310      1320 

     1260      1270      1280      1290      1300      1310        
pF1KB3 YKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSIL
            1330      1340      1350      1360      1370      1380 

     1320      1330      1340      1350      1360      1370        
pF1KB3 EQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALG
            1390      1400      1410      1420      1430      1440 

     1380      1390      1400      1410      1420      1430        
pF1KB3 QIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVC
            1450      1460      1470      1480      1490      1500 

     1440      1450      1460      1470      1480      1490        
pF1KB3 AMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNE
            1510      1520      1530      1540      1550      1560 

     1500      1510      1520      1530      1540      1550        
pF1KB3 TFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEI
            1570      1580      1590      1600      1610      1620 

     1560      1570      1580      1590      1600      1610        
pF1KB3 LLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVID
            1630      1640      1650      1660      1670      1680 

     1620      1630      1640      1650      1660      1670        
pF1KB3 CFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFH
            1690      1700      1710      1720      1730      1740 

     1680      1690      1700      1710      1720      1730        
pF1KB3 LPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLV
            1750      1760      1770      1780      1790      1800 

     1740      1750      1760      1770      1780      1790        
pF1KB3 PPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDP
            1810      1820      1830      1840      1850      1860 

     1800                       1810      1820      1830      1840 
pF1KB3 GLPA-----------------EEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNL
       ::::                 :::::::::::::::::::::::::::::::::::::::
XP_005 GLPAVFLRPGAGIPRGSRAWAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNL
            1870      1880      1890      1900      1910      1920 

            1850      1860      1870      1880      1890      1900 
pF1KB3 GTPGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTPGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKV
            1930      1940      1950      1960      1970      1980 

            1910      1920      1930      1940      1950      1960 
pF1KB3 MASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLR
            1990      2000      2010      2020      2030      2040 

            1970      1980      1990      2000      2010      2020 
pF1KB3 HPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHG
            2050      2060      2070      2080      2090      2100 

            2030      2040      2050      2060      2070      2080 
pF1KB3 RTVHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTVHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYM
            2110      2120      2130      2140      2150      2160 

            2090      2100      2110      2120      2130      2140 
pF1KB3 TRIQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TRIQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYF
            2170      2180      2190      2200      2210      2220 

            2150      2160  
pF1KB3 RQAENGMYIRMALLATVLGRF
       :::::::::::::::::::::
XP_005 RQAENGMYIRMALLATVLGRF
            2230      2240  

>>NP_001116106 (OMIM: 237300,608307,615371) carbamoyl-ph  (1049 aa)
 initn: 2868 init1: 1545 opt: 2170  Z-score: 1451.4  bits: 281.2 E(85289): 4.2e-74
Smith-Waterman score: 3069; 48.8% identity (73.2% similar) in 1037 aa overlap (423-1377:1-1026)

            400       410       420       430       440            
pF1KB3 PRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQ-GL--ADK
                                     .::::..:.:.:::::.:::.. ::  :: 
NP_001                               MKEENVKTVLMNPNIASVQTNEVGLKQADT
                                             10        20        30

     450       460       470       480       490       500         
pF1KB3 VYFLPITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETI
       ::::::::..::.::. :.:::..: .:::::::::::: : ::: .:::.:::: ::.:
NP_001 VYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESI
               40        50        60        70        80        90

     510       520       530       540       550       560         
pF1KB3 ELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFAS
         ::::. :. .. ::.:..::: :..:.:.:  ::. .::::..:.:.::::::::.  
NP_001 MATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICP
              100       110       120       130       140       150

     570       580       590       600       610                   
pF1KB3 NREELSALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVT---------------
       ::: :  : . ::: :.:.::.::. :::::::::::::  ::::               
NP_001 NRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTG
              160       170       180       190       200       210

                                                          620      
pF1KB3 ------------------------------------------------YYIIEVNARLSR
                                                       : ::::::::::
NP_001 DSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSR
              220       230       240       250       260       270

        630       640       650       660        670       680     
pF1KB3 SSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLSKF
       ::::::::::::::..:::.::::::::..: :.: :.: ::::.:: :.:::::::..:
NP_001 SSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRF
              280       290       300       310       320       330

         690       700       710       720       730               
pF1KB3 LRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVS-------DM-
         .:..::: ::::::::.:::.:::.:::::::   .  ::   . :..       :. 
NP_001 HGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLDLR
              340       350       360       370        380         

        740       750       760       770       780       790      
pF1KB3 -ELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLP
        ::  :.. ::...: :.  ..:.:.. .:: ::.:::..:. :.   . :.   .. . 
NP_001 KELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMT
     390       400       410       420       430       440         

        800       810       820       830       840       850      
pF1KB3 PDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYL
        . :..:: .:::::::.  .  ::  .:.:: . .: : ::::::.:::.:. :::::.
NP_001 EETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYV
     450       460       470       480       490       500         

        860       870       880       890       900       910      
pF1KB3 TYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETV
       :: :  ::..:    ..::: : :.::::::::::::. :. ::..: ::..:: :::::
NP_001 TYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETV
     510       520       530       540       550       560         

        920       930       940       950       960       970      
pF1KB3 STDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSP
       :::.: ::.:::.:.:.: ..:::. :   : :.:.:::.:::.:. :...  ...::::
NP_001 STDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSP
     570       580       590       600       610       620         

        980       990      1000      1010      1020      1030      
pF1KB3 EAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMN
         :: ::.:  :: .:: . ..:  :. .. :. : .: ..: :::..::::::::.:::
NP_001 LQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMN
     630       640       650       660       670       680         

       1040      1050      1060      1070      1080      1090      
pF1KB3 VAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAG
       :.... ....::  :. ::.:::::..::.. :.:...:::..:: : . :::::::.::
NP_001 VVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAG
     690       700       710       720       730       740         

       1100      1110      1120      1130      1140      1150      
pF1KB3 VHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRV
       ::::::::. : : :.  ..:..:  .. ... . ..::::.:...: ... :::::.:.
NP_001 VHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRA
     750       760       770       780       790       800         

       1160      1170      1180      1190            1200      1210
pF1KB3 SRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMT------GSGVVGVKVPQFSFSRLAG
       ::::::::::::::.. .::.:..::.:.   : :       .  :..:.:.::. ::  
NP_001 SRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRD
     810       820       830       840       850       860         

             1220      1230      1240      1250      1260      1270
pF1KB3 ADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVR
       :: .:  ::.:::::: :::.   :.::::::::::::.:.::. : . . . ..: ...
NP_001 ADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGI-QQSFRPRFLGVAE
     870       880       890       900       910        920        

             1280      1290      1300      1310      1320      1330
pF1KB3 LLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVI
        :.. :..:.:. .:.:. . ..: .: : :  .:   :. :   :: . . . ...:::
NP_001 QLHNEGFKLFATEATSDWLNANNVPATPVAWPSQE---GQNPSLSSIRKLIRDGSIDLVI
      930       940       950       960          970       980     

             1340      1350      1360      1370      1380      1390
pF1KB3 NLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHV
       ::   .      ..::  .:  :: :.: ..::. ... ::::.::.             
NP_001 NLPNNN------TKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFH
         990            1000      1010      1020      1030         

             1400      1410      1420      1430      1440      1450
pF1KB3 DCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDA
                                                                   
NP_001 YRQYSAGKAA                                                  
    1040                                                           

>>XP_011508945 (OMIM: 237300,608307,615371) PREDICTED: c  (1500 aa)
 initn: 3922 init1: 1545 opt: 2170  Z-score: 1449.1  bits: 281.3 E(85289): 5.6e-74
Smith-Waterman score: 4311; 48.5% identity (73.5% similar) in 1432 aa overlap (29-1377:73-1477)

                 10        20        30        40        50        
pF1KB3   MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIG
                                     :.::. :::::.:::.::.:::... :.::
XP_011 AQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIG
             50        60        70        80        90       100  

       60         70        80        90       100       110       
pF1KB3 NYGIPPDE-MDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQ
       : : :    .::.:: :..::.::.:..:.: .     .:: ::..: .:::.. .:.. 
XP_011 NGGAPDTTALDELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIY
            110       120       130       140       150       160  

       120       130       140       150       160       170       
pF1KB3 GVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPR
       ::::: ::: .:..:..:::.  .: .:  . :.::: . :. ::: :  .:.. :.  .
XP_011 GVDTRMLTKIIRDKGTMLGKIEFEG-QP--VDFVDPNKQNLIAEVSTKDVKVYGKGNPTK
            170       180          190       200       210         

       180       190       200       210       220       230       
pF1KB3 ILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLS
       ..:.:::.: : :: : .::::: .:::.: . ..::.:.....:::.::    ..... 
XP_011 VVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVR
     220       230       240       250       260       270         

       240       250       260       270       280       290       
pF1KB3 RVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGF
       ..:     .:.:::  :. . .:: ::::::: ..:::.::: : . . . :.:.::::.
XP_011 KILESDRKEPLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGY
     280       290       300       310       320       330         

       300       310       320       330       340       350       
pF1KB3 AVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETV
       :.. ..::: : :::.:.:: .::::.:.: :::.::::::   :: : : ::: :.  .
XP_011 ALD-NTLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLI
     340        350       360       370       380       390        

       360       370       380       390       400       410       
pF1KB3 KEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGS
       :.. : .         .:  :  :.. .    .    :::::::::::::::::::::::
XP_011 KKGKATT---------ITSVLPKPALVASRVEVS---KVLILGSGGLSIGQAGEFDYSGS
      400                410       420          430       440      

       420       430       440          450       460       470    
pF1KB3 QAIKALKEENIQTLLINPNIATVQTSQ-GL--ADKVYFLPITPHYVTQVIRNERPDGVLL
       ::.::.::::..:.:.:::::.:::.. ::  :: ::::::::..::.::. :.:::..:
XP_011 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLIL
        450       460       470       480       490       500      

          480       490       500       510       520       530    
pF1KB3 TFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEA
        .:::::::::::: : ::: .:::.:::: ::.:  ::::. :. .. ::.:..::: :
XP_011 GMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFA
        510       520       530       540       550       560      

          540       550       560       570       580       590    
pF1KB3 ANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSL
       ..:.:.:  ::. .::::..:.:.::::::::.  ::: :  : . ::: :.:.::.::.
XP_011 VESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSV
        570       580       590       600       610       620      

          600       610                                            
pF1KB3 KGWKEIEYEVVRDAYGNCVT----------------------------------------
        :::::::::::::  ::::                                        
XP_011 TGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSIN
        630       640       650       660       670       680      

                                 620       630       640       650 
pF1KB3 -----------------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIP
                              : ::::::::::::::::::::::::..:::.:::::
XP_011 VVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIP
        690       700       710       720       730       740      

             660        670       680       690       700       710
pF1KB3 LPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFE
       :::..: :.: :.: ::::.:: :.:::::::..:  .:..::: ::::::::.:::.::
XP_011 LPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFE
        750       760       770       780       790       800      

              720       730                740       750       760 
pF1KB3 EAFQKALRMVDENCVGFDHTVKPVS-------DM--ELETPTDKRIFVVAAALWAGYSVD
       :.:::::::   .  ::   . :..       :.  ::  :.. ::...: :.  ..:.:
XP_011 ESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLD
        810       820        830       840       850       860     

             770       780       790       800       810       820 
pF1KB3 RLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTE
       .. .:: ::.:::..:. :.   . :.   .. .  . :..:: .:::::::.  .  ::
XP_011 EIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTE
         870       880       890       900       910       920     

             830       840       850       860       870       880 
pF1KB3 LAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYR
         .:.:: . .: : ::::::.:::.:. :::::.:: :  ::..:    ..::: : :.
XP_011 AQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYH
         930       940       950       960       970       980     

             890       900       910       920       930       940 
pF1KB3 IGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYE
       ::::::::::::. :. ::..: ::..:: ::::::::.: ::.:::.:.:.: ..:::.
XP_011 IGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYH
         990      1000      1010      1020      1030      1040     

             950       960       970       980       990      1000 
pF1KB3 LENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQ
        :   : :.:.:::.:::.:. :...  ...::::  :: ::.:  :: .:: . ..:  
XP_011 QEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP
        1050      1060      1070      1080      1090      1100     

            1010      1020      1030      1040      1050      1060 
pF1KB3 WRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVV
       :. .. :. : .: ..: :::..::::::::.::::.... ....::  :. ::.:::::
XP_011 WKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVV
        1110      1120      1130      1140      1150      1160     

            1070      1080      1090      1100      1110      1120 
pF1KB3 ISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKA
       ..::.. :.:...:::..:: : . :::::::.::::::::::. : : :.  ..:..: 
XP_011 LTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKD
        1170      1180      1190      1200      1210      1220     

            1130      1140      1150      1160      1170      1180 
pF1KB3 IVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMG
        .. ... . ..::::.:...: ... :::::.:.::::::::::::::.. .::.:..:
XP_011 ATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIG
        1230      1240      1250      1260      1270      1280     

            1190            1200      1210      1220      1230     
pF1KB3 EEVEPVGLMT------GSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEA
       :.:.   : :       .  :..:.:.::. ::  :: .:  ::.:::::: :::.   :
XP_011 ENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTA
        1290      1300      1310      1320      1330      1340     

        1240      1250      1260      1270      1280      1290     
pF1KB3 YLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVK
       .::::::::::::.:.::. : . . . ..: ... :.. :..:.:. .:.:. . ..: 
XP_011 FLKAMLSTGFKIPQKGILIGI-QQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVP
        1350      1360       1370      1380      1390      1400    

        1300      1310      1320      1330      1340      1350     
pF1KB3 VTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRL
       .: : :  .:   :. :   :: . . . ...:::::   .      ..::  .:  :: 
XP_011 ATPVAWPSQE---GQNPSLSSIRKLIRDGSIDLVINLPNNN------TKFVHDNYVIRRT
         1410         1420      1430      1440            1450     

        1360      1370      1380      1390      1400      1410     
pF1KB3 AADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPG
       :.: ..::. ... ::::.::.                                      
XP_011 AVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA               
        1460      1470      1480      1490      1500               

>>XP_011508946 (OMIM: 237300,608307,615371) PREDICTED: c  (1500 aa)
 initn: 3922 init1: 1545 opt: 2170  Z-score: 1449.1  bits: 281.3 E(85289): 5.6e-74
Smith-Waterman score: 4311; 48.5% identity (73.5% similar) in 1432 aa overlap (29-1377:73-1477)

                 10        20        30        40        50        
pF1KB3   MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIG
                                     :.::. :::::.:::.::.:::... :.::
XP_011 AQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIG
             50        60        70        80        90       100  

       60         70        80        90       100       110       
pF1KB3 NYGIPPDE-MDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQ
       : : :    .::.:: :..::.::.:..:.: .     .:: ::..: .:::.. .:.. 
XP_011 NGGAPDTTALDELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIY
            110       120       130       140       150       160  

       120       130       140       150       160       170       
pF1KB3 GVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPR
       ::::: ::: .:..:..:::.  .: .:  . :.::: . :. ::: :  .:.. :.  .
XP_011 GVDTRMLTKIIRDKGTMLGKIEFEG-QP--VDFVDPNKQNLIAEVSTKDVKVYGKGNPTK
            170       180          190       200       210         

       180       190       200       210       220       230       
pF1KB3 ILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLS
       ..:.:::.: : :: : .::::: .:::.: . ..::.:.....:::.::    ..... 
XP_011 VVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVR
     220       230       240       250       260       270         

       240       250       260       270       280       290       
pF1KB3 RVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGF
       ..:     .:.:::  :. . .:: ::::::: ..:::.::: : . . . :.:.::::.
XP_011 KILESDRKEPLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGY
     280       290       300       310       320       330         

       300       310       320       330       340       350       
pF1KB3 AVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETV
       :.. ..::: : :::.:.:: .::::.:.: :::.::::::   :: : : ::: :.  .
XP_011 ALD-NTLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLI
     340        350       360       370       380       390        

       360       370       380       390       400       410       
pF1KB3 KEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGS
       :.. : .         .:  :  :.. .    .    :::::::::::::::::::::::
XP_011 KKGKATT---------ITSVLPKPALVASRVEVS---KVLILGSGGLSIGQAGEFDYSGS
      400                410       420          430       440      

       420       430       440          450       460       470    
pF1KB3 QAIKALKEENIQTLLINPNIATVQTSQ-GL--ADKVYFLPITPHYVTQVIRNERPDGVLL
       ::.::.::::..:.:.:::::.:::.. ::  :: ::::::::..::.::. :.:::..:
XP_011 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLIL
        450       460       470       480       490       500      

          480       490       500       510       520       530    
pF1KB3 TFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEA
        .:::::::::::: : ::: .:::.:::: ::.:  ::::. :. .. ::.:..::: :
XP_011 GMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFA
        510       520       530       540       550       560      

          540       550       560       570       580       590    
pF1KB3 ANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSL
       ..:.:.:  ::. .::::..:.:.::::::::.  ::: :  : . ::: :.:.::.::.
XP_011 VESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSV
        570       580       590       600       610       620      

          600       610                                            
pF1KB3 KGWKEIEYEVVRDAYGNCVT----------------------------------------
        :::::::::::::  ::::                                        
XP_011 TGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSIN
        630       640       650       660       670       680      

                                 620       630       640       650 
pF1KB3 -----------------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIP
                              : ::::::::::::::::::::::::..:::.:::::
XP_011 VVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIP
        690       700       710       720       730       740      

             660        670       680       690       700       710
pF1KB3 LPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFE
       :::..: :.: :.: ::::.:: :.:::::::..:  .:..::: ::::::::.:::.::
XP_011 LPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFE
        750       760       770       780       790       800      

              720       730                740       750       760 
pF1KB3 EAFQKALRMVDENCVGFDHTVKPVS-------DM--ELETPTDKRIFVVAAALWAGYSVD
       :.:::::::   .  ::   . :..       :.  ::  :.. ::...: :.  ..:.:
XP_011 ESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLD
        810       820        830       840       850       860     

             770       780       790       800       810       820 
pF1KB3 RLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTE
       .. .:: ::.:::..:. :.   . :.   .. .  . :..:: .:::::::.  .  ::
XP_011 EIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTE
         870       880       890       900       910       920     

             830       840       850       860       870       880 
pF1KB3 LAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYR
         .:.:: . .: : ::::::.:::.:. :::::.:: :  ::..:    ..::: : :.
XP_011 AQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYH
         930       940       950       960       970       980     

             890       900       910       920       930       940 
pF1KB3 IGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYE
       ::::::::::::. :. ::..: ::..:: ::::::::.: ::.:::.:.:.: ..:::.
XP_011 IGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYH
         990      1000      1010      1020      1030      1040     

             950       960       970       980       990      1000 
pF1KB3 LENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQ
        :   : :.:.:::.:::.:. :...  ...::::  :: ::.:  :: .:: . ..:  
XP_011 QEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP
        1050      1060      1070      1080      1090      1100     

            1010      1020      1030      1040      1050      1060 
pF1KB3 WRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVV
       :. .. :. : .: ..: :::..::::::::.::::.... ....::  :. ::.:::::
XP_011 WKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVV
        1110      1120      1130      1140      1150      1160     

            1070      1080      1090      1100      1110      1120 
pF1KB3 ISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKA
       ..::.. :.:...:::..:: : . :::::::.::::::::::. : : :.  ..:..: 
XP_011 LTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKD
        1170      1180      1190      1200      1210      1220     

            1130      1140      1150      1160      1170      1180 
pF1KB3 IVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMG
        .. ... . ..::::.:...: ... :::::.:.::::::::::::::.. .::.:..:
XP_011 ATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIG
        1230      1240      1250      1260      1270      1280     

            1190            1200      1210      1220      1230     
pF1KB3 EEVEPVGLMT------GSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEA
       :.:.   : :       .  :..:.:.::. ::  :: .:  ::.:::::: :::.   :
XP_011 ENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTA
        1290      1300      1310      1320      1330      1340     

        1240      1250      1260      1270      1280      1290     
pF1KB3 YLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVK
       .::::::::::::.:.::. : . . . ..: ... :.. :..:.:. .:.:. . ..: 
XP_011 FLKAMLSTGFKIPQKGILIGI-QQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVP
        1350      1360       1370      1380      1390      1400    

        1300      1310      1320      1330      1340      1350     
pF1KB3 VTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRL
       .: : :  .:   :. :   :: . . . ...:::::   .      ..::  .:  :: 
XP_011 ATPVAWPSQE---GQNPSLSSIRKLIRDGSIDLVINLPNNN------TKFVHDNYVIRRT
         1410         1420      1430      1440            1450     

        1360      1370      1380      1390      1400      1410     
pF1KB3 AADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPG
       :.: ..::. ... ::::.::.                                      
XP_011 AVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA               
        1460      1470      1480      1490      1500               

>>XP_011508943 (OMIM: 237300,608307,615371) PREDICTED: c  (1500 aa)
 initn: 3922 init1: 1545 opt: 2170  Z-score: 1449.1  bits: 281.3 E(85289): 5.6e-74
Smith-Waterman score: 4311; 48.5% identity (73.5% similar) in 1432 aa overlap (29-1377:73-1477)

                 10        20        30        40        50        
pF1KB3   MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIG
                                     :.::. :::::.:::.::.:::... :.::
XP_011 AQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIG
             50        60        70        80        90       100  

       60         70        80        90       100       110       
pF1KB3 NYGIPPDE-MDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQ
       : : :    .::.:: :..::.::.:..:.: .     .:: ::..: .:::.. .:.. 
XP_011 NGGAPDTTALDELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIY
            110       120       130       140       150       160  

       120       130       140       150       160       170       
pF1KB3 GVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPR
       ::::: ::: .:..:..:::.  .: .:  . :.::: . :. ::: :  .:.. :.  .
XP_011 GVDTRMLTKIIRDKGTMLGKIEFEG-QP--VDFVDPNKQNLIAEVSTKDVKVYGKGNPTK
            170       180          190       200       210         

       180       190       200       210       220       230       
pF1KB3 ILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLS
       ..:.:::.: : :: : .::::: .:::.: . ..::.:.....:::.::    ..... 
XP_011 VVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVR
     220       230       240       250       260       270         

       240       250       260       270       280       290       
pF1KB3 RVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGF
       ..:     .:.:::  :. . .:: ::::::: ..:::.::: : . . . :.:.::::.
XP_011 KILESDRKEPLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGY
     280       290       300       310       320       330         

       300       310       320       330       340       350       
pF1KB3 AVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETV
       :.. ..::: : :::.:.:: .::::.:.: :::.::::::   :: : : ::: :.  .
XP_011 ALD-NTLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLI
     340        350       360       370       380       390        

       360       370       380       390       400       410       
pF1KB3 KEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGS
       :.. : .         .:  :  :.. .    .    :::::::::::::::::::::::
XP_011 KKGKATT---------ITSVLPKPALVASRVEVS---KVLILGSGGLSIGQAGEFDYSGS
      400                410       420          430       440      

       420       430       440          450       460       470    
pF1KB3 QAIKALKEENIQTLLINPNIATVQTSQ-GL--ADKVYFLPITPHYVTQVIRNERPDGVLL
       ::.::.::::..:.:.:::::.:::.. ::  :: ::::::::..::.::. :.:::..:
XP_011 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLIL
        450       460       470       480       490       500      

          480       490       500       510       520       530    
pF1KB3 TFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEA
        .:::::::::::: : ::: .:::.:::: ::.:  ::::. :. .. ::.:..::: :
XP_011 GMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFA
        510       520       530       540       550       560      

          540       550       560       570       580       590    
pF1KB3 ANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSL
       ..:.:.:  ::. .::::..:.:.::::::::.  ::: :  : . ::: :.:.::.::.
XP_011 VESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSV
        570       580       590       600       610       620      

          600       610                                            
pF1KB3 KGWKEIEYEVVRDAYGNCVT----------------------------------------
        :::::::::::::  ::::                                        
XP_011 TGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSIN
        630       640       650       660       670       680      

                                 620       630       640       650 
pF1KB3 -----------------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIP
                              : ::::::::::::::::::::::::..:::.:::::
XP_011 VVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIP
        690       700       710       720       730       740      

             660        670       680       690       700       710
pF1KB3 LPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFE
       :::..: :.: :.: ::::.:: :.:::::::..:  .:..::: ::::::::.:::.::
XP_011 LPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFE
        750       760       770       780       790       800      

              720       730                740       750       760 
pF1KB3 EAFQKALRMVDENCVGFDHTVKPVS-------DM--ELETPTDKRIFVVAAALWAGYSVD
       :.:::::::   .  ::   . :..       :.  ::  :.. ::...: :.  ..:.:
XP_011 ESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLD
        810       820        830       840       850       860     

             770       780       790       800       810       820 
pF1KB3 RLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTE
       .. .:: ::.:::..:. :.   . :.   .. .  . :..:: .:::::::.  .  ::
XP_011 EIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTE
         870       880       890       900       910       920     

             830       840       850       860       870       880 
pF1KB3 LAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYR
         .:.:: . .: : ::::::.:::.:. :::::.:: :  ::..:    ..::: : :.
XP_011 AQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYH
         930       940       950       960       970       980     

             890       900       910       920       930       940 
pF1KB3 IGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYE
       ::::::::::::. :. ::..: ::..:: ::::::::.: ::.:::.:.:.: ..:::.
XP_011 IGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYH
         990      1000      1010      1020      1030      1040     

             950       960       970       980       990      1000 
pF1KB3 LENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQ
        :   : :.:.:::.:::.:. :...  ...::::  :: ::.:  :: .:: . ..:  
XP_011 QEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP
        1050      1060      1070      1080      1090      1100     

            1010      1020      1030      1040      1050      1060 
pF1KB3 WRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVV
       :. .. :. : .: ..: :::..::::::::.::::.... ....::  :. ::.:::::
XP_011 WKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVV
        1110      1120      1130      1140      1150      1160     

            1070      1080      1090      1100      1110      1120 
pF1KB3 ISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKA
       ..::.. :.:...:::..:: : . :::::::.::::::::::. : : :.  ..:..: 
XP_011 LTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKD
        1170      1180      1190      1200      1210      1220     

            1130      1140      1150      1160      1170      1180 
pF1KB3 IVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMG
        .. ... . ..::::.:...: ... :::::.:.::::::::::::::.. .::.:..:
XP_011 ATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIG
        1230      1240      1250      1260      1270      1280     

            1190            1200      1210      1220      1230     
pF1KB3 EEVEPVGLMT------GSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEA
       :.:.   : :       .  :..:.:.::. ::  :: .:  ::.:::::: :::.   :
XP_011 ENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTA
        1290      1300      1310      1320      1330      1340     

        1240      1250      1260      1270      1280      1290     
pF1KB3 YLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVK
       .::::::::::::.:.::. : . . . ..: ... :.. :..:.:. .:.:. . ..: 
XP_011 FLKAMLSTGFKIPQKGILIGI-QQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVP
        1350      1360       1370      1380      1390      1400    

        1300      1310      1320      1330      1340      1350     
pF1KB3 VTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRL
       .: : :  .:   :. :   :: . . . ...:::::   .      ..::  .:  :: 
XP_011 ATPVAWPSQE---GQNPSLSSIRKLIRDGSIDLVINLPNNN------TKFVHDNYVIRRT
         1410         1420      1430      1440            1450     

        1360      1370      1380      1390      1400      1410     
pF1KB3 AADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPG
       :.: ..::. ... ::::.::.                                      
XP_011 AVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA               
        1460      1470      1480      1490      1500               

>>XP_011508944 (OMIM: 237300,608307,615371) PREDICTED: c  (1500 aa)
 initn: 3922 init1: 1545 opt: 2170  Z-score: 1449.1  bits: 281.3 E(85289): 5.6e-74
Smith-Waterman score: 4311; 48.5% identity (73.5% similar) in 1432 aa overlap (29-1377:73-1477)

                 10        20        30        40        50        
pF1KB3   MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIG
                                     :.::. :::::.:::.::.:::... :.::
XP_011 AQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIG
             50        60        70        80        90       100  

       60         70        80        90       100       110       
pF1KB3 NYGIPPDE-MDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQ
       : : :    .::.:: :..::.::.:..:.: .     .:: ::..: .:::.. .:.. 
XP_011 NGGAPDTTALDELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIY
            110       120       130       140       150       160  

       120       130       140       150       160       170       
pF1KB3 GVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPR
       ::::: ::: .:..:..:::.  .: .:  . :.::: . :. ::: :  .:.. :.  .
XP_011 GVDTRMLTKIIRDKGTMLGKIEFEG-QP--VDFVDPNKQNLIAEVSTKDVKVYGKGNPTK
            170       180          190       200       210         

       180       190       200       210       220       230       
pF1KB3 ILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLS
       ..:.:::.: : :: : .::::: .:::.: . ..::.:.....:::.::    ..... 
XP_011 VVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVR
     220       230       240       250       260       270         

       240       250       260       270       280       290       
pF1KB3 RVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGF
       ..:     .:.:::  :. . .:: ::::::: ..:::.::: : . . . :.:.::::.
XP_011 KILESDRKEPLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGY
     280       290       300       310       320       330         

       300       310       320       330       340       350       
pF1KB3 AVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETV
       :.. ..::: : :::.:.:: .::::.:.: :::.::::::   :: : : ::: :.  .
XP_011 ALD-NTLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLI
     340        350       360       370       380       390        

       360       370       380       390       400       410       
pF1KB3 KEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGS
       :.. : .         .:  :  :.. .    .    :::::::::::::::::::::::
XP_011 KKGKATT---------ITSVLPKPALVASRVEVS---KVLILGSGGLSIGQAGEFDYSGS
      400                410       420          430       440      

       420       430       440          450       460       470    
pF1KB3 QAIKALKEENIQTLLINPNIATVQTSQ-GL--ADKVYFLPITPHYVTQVIRNERPDGVLL
       ::.::.::::..:.:.:::::.:::.. ::  :: ::::::::..::.::. :.:::..:
XP_011 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLIL
        450       460       470       480       490       500      

          480       490       500       510       520       530    
pF1KB3 TFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEA
        .:::::::::::: : ::: .:::.:::: ::.:  ::::. :. .. ::.:..::: :
XP_011 GMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFA
        510       520       530       540       550       560      

          540       550       560       570       580       590    
pF1KB3 ANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSL
       ..:.:.:  ::. .::::..:.:.::::::::.  ::: :  : . ::: :.:.::.::.
XP_011 VESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSV
        570       580       590       600       610       620      

          600       610                                            
pF1KB3 KGWKEIEYEVVRDAYGNCVT----------------------------------------
        :::::::::::::  ::::                                        
XP_011 TGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSIN
        630       640       650       660       670       680      

                                 620       630       640       650 
pF1KB3 -----------------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIP
                              : ::::::::::::::::::::::::..:::.:::::
XP_011 VVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIP
        690       700       710       720       730       740      

             660        670       680       690       700       710
pF1KB3 LPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFE
       :::..: :.: :.: ::::.:: :.:::::::..:  .:..::: ::::::::.:::.::
XP_011 LPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFE
        750       760       770       780       790       800      

              720       730                740       750       760 
pF1KB3 EAFQKALRMVDENCVGFDHTVKPVS-------DM--ELETPTDKRIFVVAAALWAGYSVD
       :.:::::::   .  ::   . :..       :.  ::  :.. ::...: :.  ..:.:
XP_011 ESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLD
        810       820        830       840       850       860     

             770       780       790       800       810       820 
pF1KB3 RLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTE
       .. .:: ::.:::..:. :.   . :.   .. .  . :..:: .:::::::.  .  ::
XP_011 EIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTE
         870       880       890       900       910       920     

             830       840       850       860       870       880 
pF1KB3 LAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYR
         .:.:: . .: : ::::::.:::.:. :::::.:: :  ::..:    ..::: : :.
XP_011 AQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYH
         930       940       950       960       970       980     

             890       900       910       920       930       940 
pF1KB3 IGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYE
       ::::::::::::. :. ::..: ::..:: ::::::::.: ::.:::.:.:.: ..:::.
XP_011 IGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYH
         990      1000      1010      1020      1030      1040     

             950       960       970       980       990      1000 
pF1KB3 LENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQ
        :   : :.:.:::.:::.:. :...  ...::::  :: ::.:  :: .:: . ..:  
XP_011 QEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP
        1050      1060      1070      1080      1090      1100     

            1010      1020      1030      1040      1050      1060 
pF1KB3 WRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVV
       :. .. :. : .: ..: :::..::::::::.::::.... ....::  :. ::.:::::
XP_011 WKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVV
        1110      1120      1130      1140      1150      1160     

            1070      1080      1090      1100      1110      1120 
pF1KB3 ISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKA
       ..::.. :.:...:::..:: : . :::::::.::::::::::. : : :.  ..:..: 
XP_011 LTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKD
        1170      1180      1190      1200      1210      1220     

            1130      1140      1150      1160      1170      1180 
pF1KB3 IVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMG
        .. ... . ..::::.:...: ... :::::.:.::::::::::::::.. .::.:..:
XP_011 ATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIG
        1230      1240      1250      1260      1270      1280     

            1190            1200      1210      1220      1230     
pF1KB3 EEVEPVGLMT------GSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEA
       :.:.   : :       .  :..:.:.::. ::  :: .:  ::.:::::: :::.   :
XP_011 ENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTA
        1290      1300      1310      1320      1330      1340     

        1240      1250      1260      1270      1280      1290     
pF1KB3 YLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVK
       .::::::::::::.:.::. : . . . ..: ... :.. :..:.:. .:.:. . ..: 
XP_011 FLKAMLSTGFKIPQKGILIGI-QQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVP
        1350      1360       1370      1380      1390      1400    

        1300      1310      1320      1330      1340      1350     
pF1KB3 VTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRL
       .: : :  .:   :. :   :: . . . ...:::::   .      ..::  .:  :: 
XP_011 ATPVAWPSQE---GQNPSLSSIRKLIRDGSIDLVINLPNNN------TKFVHDNYVIRRT
         1410         1420      1430      1440            1450     

        1360      1370      1380      1390      1400      1410     
pF1KB3 AADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPG
       :.: ..::. ... ::::.::.                                      
XP_011 AVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA               
        1460      1470      1480      1490      1500               

>>NP_001866 (OMIM: 237300,608307,615371) carbamoyl-phosp  (1500 aa)
 initn: 3922 init1: 1545 opt: 2170  Z-score: 1449.1  bits: 281.3 E(85289): 5.6e-74
Smith-Waterman score: 4311; 48.5% identity (73.5% similar) in 1432 aa overlap (29-1377:73-1477)

                 10        20        30        40        50        
pF1KB3   MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIG
                                     :.::. :::::.:::.::.:::... :.::
NP_001 AQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIG
             50        60        70        80        90       100  

       60         70        80        90       100       110       
pF1KB3 NYGIPPDE-MDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQ
       : : :    .::.:: :..::.::.:..:.: .     .:: ::..: .:::.. .:.. 
NP_001 NGGAPDTTALDELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIY
            110       120       130       140       150       160  

       120       130       140       150       160       170       
pF1KB3 GVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPR
       ::::: ::: .:..:..:::.  .: .:  . :.::: . :. ::: :  .:.. :.  .
NP_001 GVDTRMLTKIIRDKGTMLGKIEFEG-QP--VDFVDPNKQNLIAEVSTKDVKVYGKGNPTK
            170       180          190       200       210         

       180       190       200       210       220       230       
pF1KB3 ILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLS
       ..:.:::.: : :: : .::::: .:::.: . ..::.:.....:::.::    ..... 
NP_001 VVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVR
     220       230       240       250       260       270         

       240       250       260       270       280       290       
pF1KB3 RVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGF
       ..:     .:.:::  :. . .:: ::::::: ..:::.::: : . . . :.:.::::.
NP_001 KILESDRKEPLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGY
     280       290       300       310       320       330         

       300       310       320       330       340       350       
pF1KB3 AVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETV
       :.. ..::: : :::.:.:: .::::.:.: :::.::::::   :: : : ::: :.  .
NP_001 ALD-NTLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLI
     340        350       360       370       380       390        

       360       370       380       390       400       410       
pF1KB3 KEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGS
       :.. : .         .:  :  :.. .    .    :::::::::::::::::::::::
NP_001 KKGKATT---------ITSVLPKPALVASRVEVS---KVLILGSGGLSIGQAGEFDYSGS
      400                410       420          430       440      

       420       430       440          450       460       470    
pF1KB3 QAIKALKEENIQTLLINPNIATVQTSQ-GL--ADKVYFLPITPHYVTQVIRNERPDGVLL
       ::.::.::::..:.:.:::::.:::.. ::  :: ::::::::..::.::. :.:::..:
NP_001 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLIL
        450       460       470       480       490       500      

          480       490       500       510       520       530    
pF1KB3 TFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEA
        .:::::::::::: : ::: .:::.:::: ::.:  ::::. :. .. ::.:..::: :
NP_001 GMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFA
        510       520       530       540       550       560      

          540       550       560       570       580       590    
pF1KB3 ANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSL
       ..:.:.:  ::. .::::..:.:.::::::::.  ::: :  : . ::: :.:.::.::.
NP_001 VESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSV
        570       580       590       600       610       620      

          600       610                                            
pF1KB3 KGWKEIEYEVVRDAYGNCVT----------------------------------------
        :::::::::::::  ::::                                        
NP_001 TGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSIN
        630       640       650       660       670       680      

                                 620       630       640       650 
pF1KB3 -----------------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIP
                              : ::::::::::::::::::::::::..:::.:::::
NP_001 VVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIP
        690       700       710       720       730       740      

             660        670       680       690       700       710
pF1KB3 LPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFE
       :::..: :.: :.: ::::.:: :.:::::::..:  .:..::: ::::::::.:::.::
NP_001 LPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFE
        750       760       770       780       790       800      

              720       730                740       750       760 
pF1KB3 EAFQKALRMVDENCVGFDHTVKPVS-------DM--ELETPTDKRIFVVAAALWAGYSVD
       :.:::::::   .  ::   . :..       :.  ::  :.. ::...: :.  ..:.:
NP_001 ESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLD
        810       820        830       840       850       860     

             770       780       790       800       810       820 
pF1KB3 RLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTE
       .. .:: ::.:::..:. :.   . :.   .. .  . :..:: .:::::::.  .  ::
NP_001 EIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTE
         870       880       890       900       910       920     

             830       840       850       860       870       880 
pF1KB3 LAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYR
         .:.:: . .: : ::::::.:::.:. :::::.:: :  ::..:    ..::: : :.
NP_001 AQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYH
         930       940       950       960       970       980     

             890       900       910       920       930       940 
pF1KB3 IGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYE
       ::::::::::::. :. ::..: ::..:: ::::::::.: ::.:::.:.:.: ..:::.
NP_001 IGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYH
         990      1000      1010      1020      1030      1040     

             950       960       970       980       990      1000 
pF1KB3 LENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQ
        :   : :.:.:::.:::.:. :...  ...::::  :: ::.:  :: .:: . ..:  
NP_001 QEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP
        1050      1060      1070      1080      1090      1100     

            1010      1020      1030      1040      1050      1060 
pF1KB3 WRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVV
       :. .. :. : .: ..: :::..::::::::.::::.... ....::  :. ::.:::::
NP_001 WKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVV
        1110      1120      1130      1140      1150      1160     

            1070      1080      1090      1100      1110      1120 
pF1KB3 ISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKA
       ..::.. :.:...:::..:: : . :::::::.::::::::::. : : :.  ..:..: 
NP_001 LTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKD
        1170      1180      1190      1200      1210      1220     

            1130      1140      1150      1160      1170      1180 
pF1KB3 IVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMG
        .. ... . ..::::.:...: ... :::::.:.::::::::::::::.. .::.:..:
NP_001 ATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIG
        1230      1240      1250      1260      1270      1280     

            1190            1200      1210      1220      1230     
pF1KB3 EEVEPVGLMT------GSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEA
       :.:.   : :       .  :..:.:.::. ::  :: .:  ::.:::::: :::.   :
NP_001 ENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTA
        1290      1300      1310      1320      1330      1340     

        1240      1250      1260      1270      1280      1290     
pF1KB3 YLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVK
       .::::::::::::.:.::. : . . . ..: ... :.. :..:.:. .:.:. . ..: 
NP_001 FLKAMLSTGFKIPQKGILIGI-QQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVP
        1350      1360       1370      1380      1390      1400    

        1300      1310      1320      1330      1340      1350     
pF1KB3 VTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRL
       .: : :  .:   :. :   :: . . . ...:::::   .      ..::  .:  :: 
NP_001 ATPVAWPSQE---GQNPSLSSIRKLIRDGSIDLVINLPNNN------TKFVHDNYVIRRT
         1410         1420      1430      1440            1450     

        1360      1370      1380      1390      1400      1410     
pF1KB3 AADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPG
       :.: ..::. ... ::::.::.                                      
NP_001 AVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA               
        1460      1470      1480      1490      1500               




2162 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 20:51:54 2016 done: Thu Nov  3 20:51:57 2016
 Total Scan time: 19.400 Total Display time:  1.260

Function used was FASTA [36.3.4 Apr, 2011]
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