Result of FASTA (omim) for pF1KB3039
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3039, 1124 aa
  1>>>pF1KB3039 1124 - 1124 aa - 1124 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 16.1452+/-0.000815; mu= -31.6264+/- 0.048
 mean_var=1002.2790+/-218.644, 0's: 0 Z-trim(114.3): 801  B-trim: 0 in 0/55
 Lambda= 0.040512
 statistics sampled from 23210 (24010) to 23210 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.602), E-opt: 0.2 (0.282), width:  16
 Scan time: 10.440

The best scores are:                                      opt bits E(85289)
NP_000450 (OMIM: 600195,600221) angiopoietin-1 rec (1124) 7699 468.1 1.3e-130
XP_005251618 (OMIM: 600195,600221) PREDICTED: angi (1123) 7671 466.5  4e-130
NP_001277006 (OMIM: 600195,600221) angiopoietin-1  (1081) 5451 336.7 4.5e-91
NP_001277007 (OMIM: 600195,600221) angiopoietin-1  ( 976) 5434 335.7 8.4e-91
XP_005251620 (OMIM: 600195,600221) PREDICTED: angi (1080) 5423 335.1 1.4e-90
XP_006710932 (OMIM: 600222) PREDICTED: tyrosine-pr ( 783) 1949 131.9 1.5e-29
NP_001240286 (OMIM: 600222) tyrosine-protein kinas (1093) 1949 132.0 1.9e-29
XP_005271220 (OMIM: 600222) PREDICTED: tyrosine-pr (1095) 1949 132.0 1.9e-29
NP_005415 (OMIM: 600222) tyrosine-protein kinase r (1138) 1949 132.1 1.9e-29
XP_016857696 (OMIM: 600222) PREDICTED: tyrosine-pr ( 830) 1415 100.7 3.9e-20
NP_075254 (OMIM: 100800,109800,114500,134934,14600 ( 694)  851 67.6 2.9e-10
NP_000133 (OMIM: 100800,109800,114500,134934,14600 ( 806)  851 67.7 3.2e-10
XP_006713935 (OMIM: 100800,109800,114500,134934,14 ( 807)  851 67.7 3.2e-10
NP_001156685 (OMIM: 100800,109800,114500,134934,14 ( 808)  851 67.7 3.2e-10
XP_006713932 (OMIM: 100800,109800,114500,134934,14 ( 810)  851 67.7 3.2e-10
XP_006713936 (OMIM: 100800,109800,114500,134934,14 ( 807)  849 67.6 3.4e-10
XP_011511724 (OMIM: 100800,109800,114500,134934,14 ( 808)  849 67.6 3.4e-10
XP_006713934 (OMIM: 100800,109800,114500,134934,14 ( 809)  849 67.6 3.5e-10
XP_011511722 (OMIM: 100800,109800,114500,134934,14 ( 809)  849 67.6 3.5e-10
XP_006713933 (OMIM: 100800,109800,114500,134934,14 ( 810)  849 67.6 3.5e-10
XP_006713931 (OMIM: 100800,109800,114500,134934,14 ( 811)  849 67.6 3.5e-10
NP_001138387 (OMIM: 101200,101400,101600,123150,12 ( 707)  843 67.2   4e-10
NP_001307583 (OMIM: 101200,101400,101600,123150,12 ( 593)  832 66.5 5.6e-10
XP_016868719 (OMIM: 101600,123150,136350,147950,16 ( 498)  829 66.2 5.6e-10
NP_001138391 (OMIM: 101200,101400,101600,123150,12 ( 680)  832 66.5 6.1e-10
XP_016871414 (OMIM: 101200,101400,101600,123150,12 ( 689)  832 66.5 6.2e-10
NP_001138390 (OMIM: 101200,101400,101600,123150,12 ( 704)  832 66.5 6.3e-10
NP_001138389 (OMIM: 101200,101400,101600,123150,12 ( 705)  832 66.5 6.3e-10
NP_001138388 (OMIM: 101200,101400,101600,123150,12 ( 706)  832 66.5 6.3e-10
NP_001138386 (OMIM: 101200,101400,101600,123150,12 ( 709)  832 66.5 6.3e-10
XP_016871413 (OMIM: 101200,101400,101600,123150,12 ( 725)  832 66.6 6.4e-10
XP_006717775 (OMIM: 101200,101400,101600,123150,12 ( 726)  832 66.6 6.4e-10
NP_075418 (OMIM: 101200,101400,101600,123150,12350 ( 732)  832 66.6 6.4e-10
XP_016868718 (OMIM: 101600,123150,136350,147950,16 ( 508)  826 66.0 6.5e-10
XP_016871412 (OMIM: 101200,101400,101600,123150,12 ( 749)  832 66.6 6.5e-10
XP_016871411 (OMIM: 101200,101400,101600,123150,12 ( 750)  832 66.6 6.5e-10
XP_006717774 (OMIM: 101200,101400,101600,123150,12 ( 752)  832 66.6 6.6e-10
NP_001138385 (OMIM: 101200,101400,101600,123150,12 ( 769)  832 66.6 6.6e-10
XP_016871410 (OMIM: 101200,101400,101600,123150,12 ( 804)  832 66.6 6.8e-10
XP_016871409 (OMIM: 101200,101400,101600,123150,12 ( 805)  832 66.6 6.8e-10
XP_006717773 (OMIM: 101200,101400,101600,123150,12 ( 807)  832 66.6 6.9e-10
NP_001307587 (OMIM: 101200,101400,101600,123150,12 ( 819)  832 66.6 6.9e-10
NP_000132 (OMIM: 101200,101400,101600,123150,12350 ( 821)  832 66.6 6.9e-10
NP_075259 (OMIM: 101200,101400,101600,123150,12350 ( 822)  832 66.6 6.9e-10
XP_006717771 (OMIM: 101200,101400,101600,123150,12 ( 839)  832 66.6   7e-10
XP_016868717 (OMIM: 101600,123150,136350,147950,16 ( 729)  829 66.4 7.2e-10
NP_075594 (OMIM: 101600,123150,136350,147950,16625 ( 731)  829 66.4 7.3e-10
NP_001167537 (OMIM: 101600,123150,136350,147950,16 ( 733)  829 66.4 7.3e-10
NP_075593 (OMIM: 101600,123150,136350,147950,16625 ( 733)  829 66.4 7.3e-10
XP_011532767 (OMIM: 134935) PREDICTED: fibroblast  ( 696)  828 66.3 7.3e-10


>>NP_000450 (OMIM: 600195,600221) angiopoietin-1 recepto  (1124 aa)
 initn: 7699 init1: 7699 opt: 7699  Z-score: 2465.9  bits: 468.1 E(85289): 1.3e-130
Smith-Waterman score: 7699; 100.0% identity (100.0% similar) in 1124 aa overlap (1-1124:1-1124)

               10        20        30        40        50        60
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120    
pF1KB3 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
       ::::::::::::::::::::::::::::::::::::::::::::
NP_000 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
             1090      1100      1110      1120    

>>XP_005251618 (OMIM: 600195,600221) PREDICTED: angiopoi  (1123 aa)
 initn: 5600 init1: 5429 opt: 7671  Z-score: 2457.1  bits: 466.5 E(85289): 4e-130
Smith-Waterman score: 7671; 99.8% identity (99.8% similar) in 1124 aa overlap (1-1124:1-1123)

               10        20        30        40        50        60
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE
       ::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_005 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIQRMTPKIVDLPDHIE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
       ::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAQAFQN-REEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
               790       800       810       820       830         

              850       860       870       880       890       900
pF1KB3 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
     840       850       860       870       880       890         

              910       920       930       940       950       960
pF1KB3 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
     900       910       920       930       940       950         

              970       980       990      1000      1010      1020
pF1KB3 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
     960       970       980       990      1000      1010         

             1030      1040      1050      1060      1070      1080
pF1KB3 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
    1020      1030      1040      1050      1060      1070         

             1090      1100      1110      1120    
pF1KB3 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
       ::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
    1080      1090      1100      1110      1120   

>>NP_001277006 (OMIM: 600195,600221) angiopoietin-1 rece  (1081 aa)
 initn: 5235 init1: 5235 opt: 5451  Z-score: 1756.0  bits: 336.7 E(85289): 4.5e-91
Smith-Waterman score: 7239; 96.2% identity (96.2% similar) in 1124 aa overlap (1-1124:1-1081)

               10        20        30        40        50        60
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE
                                                  :::::::::::::::::
NP_001 -------------------------------------------GIPRMTPKIVDLPDHIE
                                                         310       

              370       380       390       400       410       420
pF1KB3 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
       320       330       340       350       360       370       

              430       440       450       460       470       480
pF1KB3 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
       380       390       400       410       420       430       

              490       500       510       520       530       540
pF1KB3 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
       440       450       460       470       480       490       

              550       560       570       580       590       600
pF1KB3 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
       500       510       520       530       540       550       

              610       620       630       640       650       660
pF1KB3 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
       560       570       580       590       600       610       

              670       680       690       700       710       720
pF1KB3 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
       620       630       640       650       660       670       

              730       740       750       760       770       780
pF1KB3 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
       680       690       700       710       720       730       

              790       800       810       820       830       840
pF1KB3 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
       740       750       760       770       780       790       

              850       860       870       880       890       900
pF1KB3 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
       800       810       820       830       840       850       

              910       920       930       940       950       960
pF1KB3 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
       860       870       880       890       900       910       

              970       980       990      1000      1010      1020
pF1KB3 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
       920       930       940       950       960       970       

             1030      1040      1050      1060      1070      1080
pF1KB3 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
       980       990      1000      1010      1020      1030       

             1090      1100      1110      1120    
pF1KB3 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
       ::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
      1040      1050      1060      1070      1080 

>>NP_001277007 (OMIM: 600195,600221) angiopoietin-1 rece  (976 aa)
 initn: 4269 init1: 2976 opt: 5434  Z-score: 1751.2  bits: 335.7 E(85289): 8.4e-91
Smith-Waterman score: 6423; 95.6% identity (95.6% similar) in 1003 aa overlap (122-1124:18-976)

             100       110       120       130       140       150 
pF1KB3 KASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEE
                                     ::::::::::::::::::::::::::::::
NP_001              MDSLASLVLCGVSLLLSASFLPATLTMTVDKGDNVNISFKKVLIKEE
                            10        20        30        40       

             160       170       180       190       200       210 
pF1KB3 DAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRC
        50        60        70        80        90       100       

             220       230       240       250       260       270 
pF1KB3 EAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQ
       110       120       130       140       150       160       

             280       290       300       310       320       330 
pF1KB3 EGCKSYVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLC
       :::::::::::::::::::::::::::::                               
NP_001 EGCKSYVFCLPDPYGCSCATGWKGLQCNE-------------------------------
       170       180       190                                     

             340       350       360       370       380       390 
pF1KB3 SPGWQGLQCEREGIPRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGT
                   ::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------GIPRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGT
                    200       210       220       230       240    

             400       410       420       430       440       450 
pF1KB3 VLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAP
          250       260       270       280       290       300    

             460       470       480       490       500       510 
pF1KB3 NVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRT
          310       320       330       340       350       360    

             520       530       540       550       560       570 
pF1KB3 EYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSE
          370       380       390       400       410       420    

             580       590       600       610       620       630 
pF1KB3 DDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTA
          430       440       450       460       470       480    

             640       650       660       670       680       690 
pF1KB3 WTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKN
          490       500       510       520       530       540    

             700       710       720       730       740       750 
pF1KB3 ATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAI
          550       560       570       580       590       600    

             760       770       780       790       800       810 
pF1KB3 LGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNP
       :::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
NP_001 LGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQN-REEPAVQFNSGTLALNRKVKNNP
          610       620       630       640        650       660   

             820       830       840       850       860       870 
pF1KB3 DPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAG
           670       680       690       700       710       720   

             880       890       900       910       920       930 
pF1KB3 ELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANS
           730       740       750       760       770       780   

             940       950       960       970       980       990 
pF1KB3 TASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEV
           790       800       810       820       830       840   

            1000      1010      1020      1030      1040      1050 
pF1KB3 YVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL
           850       860       870       880       890       900   

            1060      1070      1080      1090      1100      1110 
pF1KB3 PQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKF
           910       920       930       940       950       960   

            1120    
pF1KB3 TYAGIDCSAEEAA
       :::::::::::::
NP_001 TYAGIDCSAEEAA
           970      

>>XP_005251620 (OMIM: 600195,600221) PREDICTED: angiopoi  (1080 aa)
 initn: 5057 init1: 2965 opt: 5423  Z-score: 1747.2  bits: 335.1 E(85289): 1.4e-90
Smith-Waterman score: 7211; 96.0% identity (96.0% similar) in 1124 aa overlap (1-1124:1-1080)

               10        20        30        40        50        60
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE
                                                  :: ::::::::::::::
XP_005 -------------------------------------------GIQRMTPKIVDLPDHIE
                                                         310       

              370       380       390       400       410       420
pF1KB3 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
       320       330       340       350       360       370       

              430       440       450       460       470       480
pF1KB3 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
       380       390       400       410       420       430       

              490       500       510       520       530       540
pF1KB3 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
       440       450       460       470       480       490       

              550       560       570       580       590       600
pF1KB3 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
       500       510       520       530       540       550       

              610       620       630       640       650       660
pF1KB3 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
       560       570       580       590       600       610       

              670       680       690       700       710       720
pF1KB3 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
       620       630       640       650       660       670       

              730       740       750       760       770       780
pF1KB3 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
       680       690       700       710       720       730       

              790       800       810       820       830       840
pF1KB3 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
       ::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAQAFQN-REEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
       740        750       760       770       780       790      

              850       860       870       880       890       900
pF1KB3 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
        800       810       820       830       840       850      

              910       920       930       940       950       960
pF1KB3 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
        860       870       880       890       900       910      

              970       980       990      1000      1010      1020
pF1KB3 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
        920       930       940       950       960       970      

             1030      1040      1050      1060      1070      1080
pF1KB3 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
        980       990      1000      1010      1020      1030      

             1090      1100      1110      1120    
pF1KB3 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
       ::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
       1040      1050      1060      1070      1080

>>XP_006710932 (OMIM: 600222) PREDICTED: tyrosine-protei  (783 aa)
 initn: 2188 init1: 1843 opt: 1949  Z-score: 651.5  bits: 131.9 E(85289): 1.5e-29
Smith-Waterman score: 2348; 51.0% identity (72.4% similar) in 775 aa overlap (370-1123:17-783)

     340       350       360       370       380       390         
pF1KB3 CEREGIPRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFN
                                     : :.: :.:.   . : :::::::      
XP_006               MASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAI
                             10        20        30        40      

     400       410       420       430       440       450         
pF1KB3 HTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHN
          . ..: : . :..  ::: : : :.: .:.  . :...::: : :: :: .. : ..
XP_006 VEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQS
         50        60        70        80        90       100      

     460       470       480       490        500       510        
pF1KB3 FAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQ
         ..      . :::::.. .: :.: .    :. : :  .: :::  :.:.: : . ::
XP_006 RQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQ
         110       120       130       140       150       160     

      520       530          540       550       560        570    
pF1KB3 LVRRGEGGEGHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--D
       : : ::::::  ::   .::     .  :  .: ..  ..   : ..:. :. :.    :
XP_006 LSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGD
         170       180       190       200         210       220   

            580       590       600       610        620       630 
pF1KB3 DFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTA
        : ...   .  .  ..:.. :   :. ::..: :  .: . ... .    :  :    .
XP_006 GFLLRLWDGTRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV
           230       240       250        260       270       280  

             640       650       660          670       680        
pF1KB3 WTLSDILPPQPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDV
         :    :: :.... . .. :   ..:     : :  ::. ... .: :   :   .::
XP_006 -LLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDV
             290       300       310        320       330       340

       690       700       710        720        730               
pF1KB3 KIKNATITQYQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------A
          . : :   ..::.  : :   . :  ...:. :: .    : .  ....:      :
XP_006 DRPEETSTI--IRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAA
                350       360       370       380       390        

     740       750       760       770       780        790        
pF1KB3 DLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVR-EEPAVQFNS
       . :  ..:..:..::.. ::::.: :.: .. ..:. ..:: . ..:.   ::  .::.:
XP_006 EEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSS
      400       410       420       430       440       450        

      800       810       820       830       840       850        
pF1KB3 GTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK
       :::.:.:. : .:.:  ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:
XP_006 GTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLK
      460       470       480       490       500       510        

      860       870       880       890       900       910        
pF1KB3 EYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR
       ::::..::::::::::::::::::::::::::::..:::::.::::::.:::::::::::
XP_006 EYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSR
      520       530       540       550       560       570        

      920       930       940       950       960       970        
pF1KB3 VLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVA
       :::::::::  ..:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..
XP_006 VLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLAS
      580       590       600       610       620       630        

      980       990      1000      1010      1020      1030        
pF1KB3 KIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTP
       ::::::::::.::::::::::::::::::::::::::::.:::::.::::::::::::::
XP_006 KIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTP
      640       650       660       670       680       690        

     1040      1050      1060      1070      1080      1090        
pF1KB3 YCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEE
       ::::::::::::::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: 
XP_006 YCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEA
      700       710       720       730       740       750        

     1100      1110      1120    
pF1KB3 RKTYVNTTLYEKFTYAGIDCSAEEAA
       ::.::: .:.:.::::::: .:::: 
XP_006 RKAYVNMSLFENFTYAGIDATAEEA 
      760       770       780    

>>NP_001240286 (OMIM: 600222) tyrosine-protein kinase re  (1093 aa)
 initn: 3040 init1: 1843 opt: 1949  Z-score: 649.8  bits: 132.0 E(85289): 1.9e-29
Smith-Waterman score: 3298; 47.5% identity (71.5% similar) in 1102 aa overlap (46-1123:9-1093)

          20        30        40        50        60        70     
pF1KB3 LSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRDFEALMNQHQDPLEVT
                                     ...: :  :. . .: . . .    ::.. 
NP_001                       MWAGAGRGSDAWGP--PLLLEKDDRIVRTPPGPPLRL-
                                     10          20        30      

          80        90        100       110       120       130    
pF1KB3 QDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVD
          .:. ...:. .   : : . :.. : : . ..  :.  ..    : .::  .: ::.
NP_001 ---ARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVN
             40        50        60        70        80        90  

          140       150       160       170        180       190   
pF1KB3 KGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDI-LEVHLPHAQPQDAGVYSARY
       :::.. .: .    :. :..  .:::.....  ::. :  . ..::..:: ..:.::: :
NP_001 KGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATY
            100       110       120       130       140       150  

           200       210       220       230       240       250   
pF1KB3 IGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEK
       . .. . ::: ::::: : : .::: :.. : .:...::::.  :::.::::: :  ::.
NP_001 LEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQ
            160       170       180       190       200       210  

           260       270       280       290       300       310   
pF1KB3 ACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKL
       ::.   ::..:.:.: :  ::.. .:::::::::::..::.: ::.::: :: .: ::.:
NP_001 ACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRL
            220       230       240       250       260       270  

           320       330       340       350       360        370  
pF1KB3 RCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIEVNSGKFNPI-CKA
       .:.:.::  ::::.::.:  ::.:..::.    :. :.:... ...: :   .  : : :
NP_001 QCQCQNGGTCDRFSGCVCPSGWHGVHCEKSD--RI-PQILNMASELEFNLETMPRINCAA
            280       290       300          310       320         

            380       390       400       410       420       430  
pF1KB3 SGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGM
       .: :.:.   . : :::::::         . ..: : . :..  ::: : : :.: .:.
NP_001 AGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQ
     330       340       350       360       370       380         

            440       450       460       470       480       490  
pF1KB3 VEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAW
         . :...::: : :: :: .. : ..  ..      . :::::.. .: :.: .    :
NP_001 DSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDW
     390       400       410        420       430       440        

             500       510       520       530          540        
pF1KB3 QHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTT---ASIGLPPPRG
       . : :  .: :::  :.:.: : . ::: : ::::::  ::   .::     .  :  .:
NP_001 STIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEG
      450       460       470       480       490       500        

      550       560        570         580       590       600     
pF1KB3 LNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNL
        ..  ..   : ..:. :. :.    : : ...   .  .  ..:.. :   :. ::..:
NP_001 WHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTA-LLTGL
      510         520       530       540       550       560      

         610        620       630       640       650       660    
pF1KB3 HPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT---I
        :  .: . ... .    :  :    .  :    :: :.... . .. :   ..:     
NP_001 TPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPPAPRHLHAQALSDSEIQLTWKHPEA
         570       580       590        600       610       620    

             670       680        690       700       710          
pF1KB3 LDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQYQLKGLEPETAYQVDIFAE-NNIG
       : :  ::. ... .: :   :   .::   . : :   ..::.  : :   . :  ...:
NP_001 LPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETSTI--IRGLNASTRYLFRMRASIQGLG
           630       640       650         660       670       680 

     720        730             740       750       760       770  
pF1KB3 S-SNPAFSHELVTLPESQAP------ADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQL
       . :: .    : .  ....:      :. :  ..:..:..::.. ::::.: :.: .. .
NP_001 DWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCI
             690       700       710       720       730       740 

            780        790       800       810       820       830 
pF1KB3 KRANVQRRMAQAFQNVR-EEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIG
       .:. ..:: . ..:.   ::  .::.::::.:.:. : .:.:  ::::.:.:: :.:.::
NP_001 RRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIG
             750       760       770       780       790       800 

             840       850       860       870       880       890 
pF1KB3 EGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGA
       :::::::..: ::::::.:.:::: .:::::..:::::::::::::::::::::::::::
NP_001 EGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGA
             810       820       830       840       850       860 

             900       910       920       930       940       950 
pF1KB3 CEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARG
       :..:::::.::::::.::::::::::::::::::::  ..:::::::.:::.::.:.: :
NP_001 CKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANG
             870       880       890       900       910       920 

             960       970       980       990      1000      1010 
pF1KB3 MDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLN
       :.:::.::::::::::::.::::: ..::::::::::.::::::::::::::::::::::
NP_001 MQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLN
             930       940       950       960       970       980 

            1020      1030      1040      1050      1060      1070 
pF1KB3 YSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLM
       ::::::.:::::.::::::::::::::::::::::::::::::::.:.: :::::::.::
NP_001 YSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELM
             990      1000      1010      1020      1030      1040 

            1080      1090      1100      1110      1120    
pF1KB3 RQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
       :::::..::::: :::: ..:.:::: ::.::: .:.:.::::::: .:::: 
NP_001 RQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA 
            1050      1060      1070      1080      1090    

>>XP_005271220 (OMIM: 600222) PREDICTED: tyrosine-protei  (1095 aa)
 initn: 2888 init1: 1843 opt: 1949  Z-score: 649.8  bits: 132.0 E(85289): 1.9e-29
Smith-Waterman score: 3020; 44.9% identity (68.0% similar) in 1143 aa overlap (14-1123:13-1095)

               10        20        30        40                 50 
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
                    :.:.. : .:.:: :. .: :..  .  :::...         .: :
XP_005  MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
                10        20        30        40        50         

              60        70        80        90        100       110
pF1KB3 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
         :. . .: . . .    ::.    ..:. ...:. .   : : . :.. : : . .. 
XP_005 --PLLLEKDDRIVRTPPGPPLR----LARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
        60        70            80        90       100       110   

              120       130       140       150       160       170
pF1KB3 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
        :.  ..    : .::  .: ::.:::.. .: .    :. :..  .:::.....  ::.
XP_005 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
           120       130       140       150       160       170   

               180       190       200       210       220         
pF1KB3 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
        :  . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
XP_005 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
           180       190       200       210       220       230   

     230       240       250       260       270       280         
pF1KB3 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
       .::::.  :::.::::: :  ::.::.   ::..:.:.: :  ::.. .:::::::::::
XP_005 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
           240       250       260       270       280       290   

     290       300       310       320       330       340         
pF1KB3 ATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMT
       ..::.: ::.:                       ::.                       
XP_005 GSGWRGSQCQE-----------------------DRI-----------------------
           300                                                     

     350       360        370       380       390       400        
pF1KB3 PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAI
       :.:... ...: :   .  : : :.: :.:.   . : :::::::         . ..: 
XP_005 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAE
       310       320       330       340       350       360       

      410       420       430       440       450       460        
pF1KB3 FTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSE
       : . :..  ::: : : :.: .:.  . :...::: : :: :: .. : ..  ..     
XP_005 FEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLV
       370       380       390       400       410        420      

      470       480       490        500       510       520       
pF1KB3 PYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGE
        . :::::.. .: :.: .    :. : :  .: :::  :.:.: : . ::: : :::::
XP_005 SFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGE
        430       440       450       460       470       480      

       530          540       550       560        570         580 
pF1KB3 GHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERR
       :  ::   .::     .  :  .: ..  ..   : ..:. :. :.    : : ...   
XP_005 GAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDG
        490       500       510         520       530       540    

             590       600       610        620       630       640
pF1KB3 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPP
       .  .  ..:.. :   :. ::..: :  .: . ... .    :  :    .  :    ::
XP_005 TRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPP
          550       560        570       580       590        600  

              650       660          670       680        690      
pF1KB3 QPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQ
        :.... . .. :   ..:     : :  ::. ... .: :   :   .::   . : : 
XP_005 APRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETST-
            610       620        630       640       650       660 

        700       710        720        730             740        
pF1KB3 YQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLL
         ..::.  : :   . :  ...:. :: .    : .  ....:      :. :  ..:.
XP_005 -IIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLI
               670       680       690       700       710         

      750       760       770       780        790       800       
pF1KB3 IAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVR-EEPAVQFNSGTLALNRKV
       .:..::.. ::::.: :.: .. ..:. ..:: . ..:.   ::  .::.::::.:.:. 
XP_005 LAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRP
     720       730       740       750       760       770         

       810       820       830       840       850       860       
pF1KB3 KNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHR
       : .:.:  ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:::::..:::
XP_005 KLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHR
     780       790       800       810       820       830         

       870       880       890       900       910       920       
pF1KB3 DFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFA
       :::::::::::::::::::::::::..:::::.::::::.::::::::::::::::::::
XP_005 DFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFA
     840       850       860       870       880       890         

       930       940       950       960       970       980       
pF1KB3 IANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR
         ..:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..:::::::::
XP_005 REHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR
     900       910       920       930       940       950         

       990      1000      1010      1020      1030      1040       
pF1KB3 GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAEL
       :.::::::::::::::::::::::::::::.:::::.:::::::::::::::::::::::
XP_005 GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAEL
     960       970       980       990      1000      1010         

      1050      1060      1070      1080      1090      1100       
pF1KB3 YEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTL
       :::::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: ::.::: .:
XP_005 YEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSL
    1020      1030      1040      1050      1060      1070         

      1110      1120    
pF1KB3 YEKFTYAGIDCSAEEAA
       .:.::::::: .:::: 
XP_005 FENFTYAGIDATAEEA 
    1080      1090      

>>NP_005415 (OMIM: 600222) tyrosine-protein kinase recep  (1138 aa)
 initn: 3040 init1: 1843 opt: 1949  Z-score: 649.6  bits: 132.1 E(85289): 1.9e-29
Smith-Waterman score: 3334; 46.9% identity (71.0% similar) in 1143 aa overlap (14-1123:13-1138)

               10        20        30        40                 50 
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
                    :.:.. : .:.:: :. .: :..  .  :::...         .: :
NP_005  MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
                10        20        30        40        50         

              60        70        80        90        100       110
pF1KB3 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
         :. . .: . . .    ::.    ..:. ...:. .   : : . :.. : : . .. 
NP_005 --PLLLEKDDRIVRTPPGPPLR----LARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
        60        70            80        90       100       110   

              120       130       140       150       160       170
pF1KB3 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
        :.  ..    : .::  .: ::.:::.. .: .    :. :..  .:::.....  ::.
NP_005 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
           120       130       140       150       160       170   

               180       190       200       210       220         
pF1KB3 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
        :  . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
NP_005 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
           180       190       200       210       220       230   

     230       240       250       260       270       280         
pF1KB3 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
       .::::.  :::.::::: :  ::.::.   ::..:.:.: :  ::.. .:::::::::::
NP_005 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
           240       250       260       270       280       290   

     290       300       310       320       330       340         
pF1KB3 ATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMT
       ..::.: ::.::: :: .: ::.:.:.:.::  ::::.::.:  ::.:..::.    :. 
NP_005 GSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKS--DRI-
           300       310       320       330       340         350 

     350       360        370       380       390       400        
pF1KB3 PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAI
       :.:... ...: :   .  : : :.: :.:.   . : :::::::         . ..: 
NP_005 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAE
              360       370       380       390       400       410

      410       420       430       440       450       460        
pF1KB3 FTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSE
       : . :..  ::: : : :.: .:.  . :...::: : :: :: .. : ..  ..     
NP_005 FEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLV
              420       430       440       450        460         

      470       480       490        500       510       520       
pF1KB3 PYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGE
        . :::::.. .: :.: .    :. : :  .: :::  :.:.: : . ::: : :::::
NP_005 SFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGE
     470       480       490       500       510       520         

       530          540       550       560        570         580 
pF1KB3 GHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERR
       :  ::   .::     .  :  .: ..  ..   : ..:. :. :.    : : ...   
NP_005 GAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDG
     530       540       550         560       570       580       

             590       600       610        620       630       640
pF1KB3 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPP
       .  .  ..:.. :   :. ::..: :  .: . ... .    :  :    .  :    ::
NP_005 TRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPP
       590       600        610       620       630        640     

              650       660          670       680        690      
pF1KB3 QPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQ
        :.... . .. :   ..:     : :  ::. ... .: :   :   .::   . : : 
NP_005 APRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETST-
         650       660       670        680       690       700    

        700       710        720        730             740        
pF1KB3 YQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLL
         ..::.  : :   . :  ...:. :: .    : .  ....:      :. :  ..:.
NP_005 -IIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLI
            710       720       730       740       750       760  

      750       760       770       780        790       800       
pF1KB3 IAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVR-EEPAVQFNSGTLALNRKV
       .:..::.. ::::.: :.: .. ..:. ..:: . ..:.   ::  .::.::::.:.:. 
NP_005 LAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRP
            770       780       790       800       810       820  

       810       820       830       840       850       860       
pF1KB3 KNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHR
       : .:.:  ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:::::..:::
NP_005 KLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHR
            830       840       850       860       870       880  

       870       880       890       900       910       920       
pF1KB3 DFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFA
       :::::::::::::::::::::::::..:::::.::::::.::::::::::::::::::::
NP_005 DFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFA
            890       900       910       920       930       940  

       930       940       950       960       970       980       
pF1KB3 IANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR
         ..:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..:::::::::
NP_005 REHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR
            950       960       970       980       990      1000  

       990      1000      1010      1020      1030      1040       
pF1KB3 GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAEL
       :.::::::::::::::::::::::::::::.:::::.:::::::::::::::::::::::
NP_005 GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAEL
           1010      1020      1030      1040      1050      1060  

      1050      1060      1070      1080      1090      1100       
pF1KB3 YEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTL
       :::::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: ::.::: .:
NP_005 YEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSL
           1070      1080      1090      1100      1110      1120  

      1110      1120    
pF1KB3 YEKFTYAGIDCSAEEAA
       .:.::::::: .:::: 
NP_005 FENFTYAGIDATAEEA 
           1130         

>>XP_016857696 (OMIM: 600222) PREDICTED: tyrosine-protei  (830 aa)
 initn: 1276 init1: 822 opt: 1415  Z-score: 482.5  bits: 100.7 E(85289): 3.9e-20
Smith-Waterman score: 1508; 33.5% identity (61.5% similar) in 806 aa overlap (14-787:13-801)

               10        20        30        40                 50 
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
                    :.:.. : .:.:: :. .: :..  .  :::...         .: :
XP_016  MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
                10        20        30        40        50         

              60        70        80        90        100       110
pF1KB3 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
         :. . .: . . .    ::...    :. ...:. .   : : . :.. : : . .. 
XP_016 --PLLLEKDDRIVRTPPGPPLRLA----RNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
        60        70        80            90       100       110   

              120       130       140       150       160       170
pF1KB3 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
        :.  ..    : .::  .: ::.:::.. .: .    :. :..  .:::.....  ::.
XP_016 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
           120       130       140       150       160       170   

               180       190       200       210       220         
pF1KB3 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
        :  . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
XP_016 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
           180       190       200       210       220       230   

     230       240       250       260       270       280         
pF1KB3 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
       .::::.  :::.::::: :  ::.::.   ::..:.:.: :  ::.. .:::::::::::
XP_016 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
           240       250       260       270       280       290   

     290       300       310       320       330       340         
pF1KB3 ATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMT
       ..::.: ::.::: :: .: ::.:.:.:.::  ::::.::.:  ::.:..::.    :. 
XP_016 GSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKS--DRI-
           300       310       320       330       340         350 

     350       360        370       380       390       400        
pF1KB3 PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAI
       :.:... ...: :   .  : : :.: :.:.   . : :::::::         . ..: 
XP_016 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAE
              360       370       380       390       400       410

      410       420       430       440       450       460        
pF1KB3 FTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSE
       : . :..  ::: : : :.: .:.  . :...::: : :: :: .. : ..  ..     
XP_016 FEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLV
              420       430       440       450        460         

      470       480       490        500       510       520       
pF1KB3 PYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGE
        . :::::.. .: :.: .    :. : :  .: :::  :.:.: : . ::: : :::::
XP_016 SFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGE
     470       480       490       500       510       520         

       530          540       550       560        570         580 
pF1KB3 GHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERR
       :  ::   .::     .  :  .: ..  ..   : ..:. :. :.    : : ...   
XP_016 GAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDG
     530       540       550         560       570       580       

             590       600       610        620       630       640
pF1KB3 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPP
       .  .  ..:.. :   :. ::..: :  .: . ... .    :  :    .  :    ::
XP_016 TRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPP
       590       600        610       620       630        640     

              650       660          670       680        690      
pF1KB3 QPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQ
        :.... . .. :   ..:     : :  ::. ... .: :   :   .::   . : : 
XP_016 APRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETSTI
         650       660       670        680       690       700    

        700       710        720        730             740        
pF1KB3 YQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLL
         ..::.  : :   . :  ...:. :: .    : .  ....:      :. :  ..:.
XP_016 --IRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLI
            710       720       730       740       750       760  

      750       760       770       780       790       800        
pF1KB3 IAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVK
       .:..::.. ::::.: :.: .. ..:. ..:: . ..:.                     
XP_016 LAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSAFLGSGASLCLHTSLADVL
            770       780       790       800       810       820  

      810       820       830       840       850       860        
pF1KB3 NNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRD
                                                                   
XP_016 SPAVATCQ                                                    
            830                                                    




1124 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 20:33:48 2016 done: Thu Nov  3 20:33:50 2016
 Total Scan time: 10.440 Total Display time:  0.450

Function used was FASTA [36.3.4 Apr, 2011]
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