FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1776, 2809 aa 1>>>pF1KA1776 2809 - 2809 aa - 2809 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7325+/-0.000589; mu= 15.2860+/- 0.036 mean_var=241.5025+/-50.827, 0's: 0 Z-trim(114.7): 580 B-trim: 144 in 2/50 Lambda= 0.082530 statistics sampled from 23944 (24638) to 23944 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.289), width: 16 Scan time: 17.850 The best scores are: opt bits E(85289) XP_016882861 (OMIM: 608529) PREDICTED: fibrillin-3 (2809) 21452 2570.6 0 NP_115823 (OMIM: 608529) fibrillin-3 precursor [Ho (2809) 21452 2570.6 0 NP_001308360 (OMIM: 608529) fibrillin-3 precursor (2809) 21452 2570.6 0 XP_016882863 (OMIM: 608529) PREDICTED: fibrillin-3 (2777) 20377 2442.6 0 XP_016882868 (OMIM: 608529) PREDICTED: fibrillin-3 (2851) 19503 2338.6 0 XP_016882865 (OMIM: 608529) PREDICTED: fibrillin-3 (2766) 15802 1897.9 0 XP_016882862 (OMIM: 608529) PREDICTED: fibrillin-3 (2789) 15655 1880.4 0 XP_016864717 (OMIM: 121050,612570,616118) PREDICTE (2861) 15312 1839.6 0 XP_016882866 (OMIM: 608529) PREDICTED: fibrillin-3 (1948) 14885 1788.5 0 NP_001990 (OMIM: 121050,612570,616118) fibrillin-2 (2912) 14009 1684.4 0 XP_016882864 (OMIM: 608529) PREDICTED: fibrillin-3 (2768) 12827 1543.7 0 NP_000129 (OMIM: 102370,129600,134797,154700,18490 (2871) 12732 1532.4 0 XP_016882867 (OMIM: 608529) PREDICTED: fibrillin-3 (1595) 12180 1466.3 0 NP_000419 (OMIM: 251750,600975,602091,613086,61481 (1821) 1604 207.2 1.9e-51 XP_011535067 (OMIM: 251750,600975,602091,613086,61 (1694) 1475 191.8 7.6e-47 XP_011525680 (OMIM: 604710,613177) PREDICTED: late (1611) 1457 189.6 3.3e-46 XP_011531157 (OMIM: 150390) PREDICTED: latent-tran (1720) 1319 173.2 3e-41 NP_996826 (OMIM: 150390) latent-transforming growt (1721) 1308 171.9 7.4e-41 XP_011531162 (OMIM: 150390) PREDICTED: latent-tran (1666) 1240 163.8 2e-38 XP_011531155 (OMIM: 150390) PREDICTED: latent-tran (1722) 1240 163.8 2e-38 NP_000618 (OMIM: 150390) latent-transforming growt (1395) 1237 163.3 2.3e-38 XP_011525688 (OMIM: 604710,613177) PREDICTED: late (1436) 1225 161.9 6.3e-38 NP_004548 (OMIM: 164951) neurogenic locus notch ho (2003) 1195 158.5 9.2e-37 XP_011525685 (OMIM: 604710,613177) PREDICTED: late (1522) 1170 155.4 6.1e-36 NP_077719 (OMIM: 102500,600275,610205) neurogenic (2471) 1171 155.8 7.6e-36 XP_016882842 (OMIM: 604710,613177) PREDICTED: late (1549) 1167 155.0 7.9e-36 XP_011539821 (OMIM: 102500,600275,610205) PREDICTE (2467) 1170 155.6 8.3e-36 XP_016856861 (OMIM: 102500,600275,610205) PREDICTE (2455) 1169 155.5 9e-36 XP_016882841 (OMIM: 604710,613177) PREDICTED: late (1591) 1163 154.6 1.1e-35 XP_011525683 (OMIM: 604710,613177) PREDICTED: late (1593) 1162 154.5 1.2e-35 XP_016859598 (OMIM: 150390) PREDICTED: latent-tran (1679) 1153 153.4 2.6e-35 XP_011525689 (OMIM: 604710,613177) PREDICTED: late (1421) 1151 153.1 2.8e-35 NP_001036010 (OMIM: 604710,613177) latent-transfor (1557) 1151 153.1 3e-35 NP_003564 (OMIM: 604710,613177) latent-transformin (1587) 1151 153.2 3e-35 XP_011539189 (OMIM: 604266) PREDICTED: multiple ep (1395) 1150 153.0 3e-35 XP_011525681 (OMIM: 604710,613177) PREDICTED: late (1595) 1151 153.2 3e-35 NP_001036009 (OMIM: 604710,613177) latent-transfor (1624) 1151 153.2 3e-35 XP_011525679 (OMIM: 604710,613177) PREDICTED: late (1635) 1151 153.2 3.1e-35 XP_011525678 (OMIM: 604710,613177) PREDICTED: late (1662) 1151 153.2 3.1e-35 XP_011525684 (OMIM: 604710,613177) PREDICTED: late (1554) 1149 152.9 3.5e-35 XP_016856862 (OMIM: 102500,600275,610205) PREDICTE (2432) 1150 153.3 4.3e-35 XP_011539822 (OMIM: 102500,600275,610205) PREDICTE (2432) 1150 153.3 4.3e-35 XP_005270958 (OMIM: 102500,600275,610205) PREDICTE (2432) 1150 153.3 4.3e-35 XP_011525687 (OMIM: 604710,613177) PREDICTED: late (1478) 1146 152.5 4.3e-35 XP_011525686 (OMIM: 604710,613177) PREDICTED: late (1480) 1146 152.5 4.3e-35 XP_011525682 (OMIM: 604710,613177) PREDICTED: late (1593) 1139 151.7 8.1e-35 NP_001159737 (OMIM: 150390) latent-transforming gr (1342) 1137 151.4 8.6e-35 XP_005264374 (OMIM: 150390) PREDICTED: latent-tran (1668) 1137 151.5 9.8e-35 XP_011531161 (OMIM: 150390) PREDICTED: latent-tran (1669) 1137 151.5 9.8e-35 XP_011531160 (OMIM: 150390) PREDICTED: latent-tran (1680) 1132 150.9 1.5e-34 >>XP_016882861 (OMIM: 608529) PREDICTED: fibrillin-3 iso (2809 aa) initn: 21452 init1: 21452 opt: 21452 Z-score: 13814.4 bits: 2570.6 E(85289): 0 Smith-Waterman score: 21452; 99.9% identity (100.0% similar) in 2809 aa overlap (1-2809:1-2809) 10 20 30 40 50 60 pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA1 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA1 DLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA1 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA1 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KA1 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KA1 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KA1 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KA1 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 pF1KA1 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 pF1KA1 GACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 pF1KA1 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 pF1KA1 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 pF1KA1 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC 1990 2000 2010 2020 2030 2040 2050 2060 2070 2080 2090 2100 pF1KA1 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC 2050 2060 2070 2080 2090 2100 2110 2120 2130 2140 2150 2160 pF1KA1 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL 2110 2120 2130 2140 2150 2160 2170 2180 2190 2200 2210 2220 pF1KA1 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA 2170 2180 2190 2200 2210 2220 2230 2240 2250 2260 2270 2280 pF1KA1 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD 2230 2240 2250 2260 2270 2280 2290 2300 2310 2320 2330 2340 pF1KA1 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP 2290 2300 2310 2320 2330 2340 2350 2360 2370 2380 2390 2400 pF1KA1 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA 2350 2360 2370 2380 2390 2400 2410 2420 2430 2440 2450 2460 pF1KA1 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL 2410 2420 2430 2440 2450 2460 2470 2480 2490 2500 2510 2520 pF1KA1 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV 2470 2480 2490 2500 2510 2520 2530 2540 2550 2560 2570 2580 pF1KA1 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG 2530 2540 2550 2560 2570 2580 2590 2600 2610 2620 2630 2640 pF1KA1 SASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: XP_016 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY 2590 2600 2610 2620 2630 2640 2650 2660 2670 2680 2690 2700 pF1KA1 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA 2650 2660 2670 2680 2690 2700 2710 2720 2730 2740 2750 2760 pF1KA1 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS 2710 2720 2730 2740 2750 2760 2770 2780 2790 2800 pF1KA1 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL 2770 2780 2790 2800 >>NP_115823 (OMIM: 608529) fibrillin-3 precursor [Homo s (2809 aa) initn: 21452 init1: 21452 opt: 21452 Z-score: 13814.4 bits: 2570.6 E(85289): 0 Smith-Waterman score: 21452; 99.9% identity (100.0% similar) in 2809 aa overlap (1-2809:1-2809) 10 20 30 40 50 60 pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA1 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA1 DLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA1 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA1 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KA1 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KA1 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KA1 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KA1 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 pF1KA1 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 pF1KA1 GACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 pF1KA1 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 pF1KA1 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 pF1KA1 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC 1990 2000 2010 2020 2030 2040 2050 2060 2070 2080 2090 2100 pF1KA1 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC 2050 2060 2070 2080 2090 2100 2110 2120 2130 2140 2150 2160 pF1KA1 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL 2110 2120 2130 2140 2150 2160 2170 2180 2190 2200 2210 2220 pF1KA1 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA 2170 2180 2190 2200 2210 2220 2230 2240 2250 2260 2270 2280 pF1KA1 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD 2230 2240 2250 2260 2270 2280 2290 2300 2310 2320 2330 2340 pF1KA1 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP 2290 2300 2310 2320 2330 2340 2350 2360 2370 2380 2390 2400 pF1KA1 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA 2350 2360 2370 2380 2390 2400 2410 2420 2430 2440 2450 2460 pF1KA1 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL 2410 2420 2430 2440 2450 2460 2470 2480 2490 2500 2510 2520 pF1KA1 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV 2470 2480 2490 2500 2510 2520 2530 2540 2550 2560 2570 2580 pF1KA1 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG 2530 2540 2550 2560 2570 2580 2590 2600 2610 2620 2630 2640 pF1KA1 SASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: NP_115 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY 2590 2600 2610 2620 2630 2640 2650 2660 2670 2680 2690 2700 pF1KA1 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA 2650 2660 2670 2680 2690 2700 2710 2720 2730 2740 2750 2760 pF1KA1 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS 2710 2720 2730 2740 2750 2760 2770 2780 2790 2800 pF1KA1 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL ::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL 2770 2780 2790 2800 >>NP_001308360 (OMIM: 608529) fibrillin-3 precursor [Hom (2809 aa) initn: 21452 init1: 21452 opt: 21452 Z-score: 13814.4 bits: 2570.6 E(85289): 0 Smith-Waterman score: 21452; 99.9% identity (100.0% similar) in 2809 aa overlap (1-2809:1-2809) 10 20 30 40 50 60 pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA1 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA1 DLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA1 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA1 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KA1 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KA1 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KA1 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KA1 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 pF1KA1 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 pF1KA1 GACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 pF1KA1 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 pF1KA1 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 pF1KA1 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC 1990 2000 2010 2020 2030 2040 2050 2060 2070 2080 2090 2100 pF1KA1 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC 2050 2060 2070 2080 2090 2100 2110 2120 2130 2140 2150 2160 pF1KA1 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL 2110 2120 2130 2140 2150 2160 2170 2180 2190 2200 2210 2220 pF1KA1 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA 2170 2180 2190 2200 2210 2220 2230 2240 2250 2260 2270 2280 pF1KA1 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD 2230 2240 2250 2260 2270 2280 2290 2300 2310 2320 2330 2340 pF1KA1 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP 2290 2300 2310 2320 2330 2340 2350 2360 2370 2380 2390 2400 pF1KA1 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA 2350 2360 2370 2380 2390 2400 2410 2420 2430 2440 2450 2460 pF1KA1 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL 2410 2420 2430 2440 2450 2460 2470 2480 2490 2500 2510 2520 pF1KA1 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV 2470 2480 2490 2500 2510 2520 2530 2540 2550 2560 2570 2580 pF1KA1 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG 2530 2540 2550 2560 2570 2580 2590 2600 2610 2620 2630 2640 pF1KA1 SASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: NP_001 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY 2590 2600 2610 2620 2630 2640 2650 2660 2670 2680 2690 2700 pF1KA1 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA 2650 2660 2670 2680 2690 2700 2710 2720 2730 2740 2750 2760 pF1KA1 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS 2710 2720 2730 2740 2750 2760 2770 2780 2790 2800 pF1KA1 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL 2770 2780 2790 2800 >>XP_016882863 (OMIM: 608529) PREDICTED: fibrillin-3 iso (2777 aa) initn: 20328 init1: 20328 opt: 20377 Z-score: 13122.7 bits: 2442.6 E(85289): 0 Smith-Waterman score: 21122; 98.7% identity (98.9% similar) in 2809 aa overlap (1-2809:1-2777) 10 20 30 40 50 60 pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC ::::::::::::::::::::::::::::::::::::::::::::::::::::::::. XP_016 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRA--- 70 80 90 100 110 130 140 150 160 170 180 pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER ::::::::::::::::::::::::::::::: XP_016 -----------------------------ICDRGCHNGGRCIGPNRCACVYGFMGPQCER 120 130 140 190 200 210 220 230 240 pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI 150 160 170 180 190 200 250 260 270 280 290 300 pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF 210 220 230 240 250 260 310 320 330 340 350 360 pF1KA1 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF 270 280 290 300 310 320 370 380 390 400 410 420 pF1KA1 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL 330 340 350 360 370 380 430 440 450 460 470 480 pF1KA1 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA 390 400 410 420 430 440 490 500 510 520 530 540 pF1KA1 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM 450 460 470 480 490 500 550 560 570 580 590 600 pF1KA1 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG 510 520 530 540 550 560 610 620 630 640 650 660 pF1KA1 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA 570 580 590 600 610 620 670 680 690 700 710 720 pF1KA1 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK 630 640 650 660 670 680 730 740 750 760 770 780 pF1KA1 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC 690 700 710 720 730 740 790 800 810 820 830 840 pF1KA1 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 750 760 770 780 790 800 850 860 870 880 890 900 pF1KA1 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL 810 820 830 840 850 860 910 920 930 940 950 960 pF1KA1 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL 870 880 890 900 910 920 970 980 990 1000 1010 1020 pF1KA1 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD 930 940 950 960 970 980 1030 1040 1050 1060 1070 1080 pF1KA1 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL 990 1000 1010 1020 1030 1040 1090 1100 1110 1120 1130 1140 pF1KA1 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC 1050 1060 1070 1080 1090 1100 1150 1160 1170 1180 1190 1200 pF1KA1 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC 1110 1120 1130 1140 1150 1160 1210 1220 1230 1240 1250 1260 pF1KA1 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS 1170 1180 1190 1200 1210 1220 1270 1280 1290 1300 1310 1320 pF1KA1 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1230 1240 1250 1260 1270 1280 1330 1340 1350 1360 1370 1380 pF1KA1 DLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1290 1300 1310 1320 1330 1340 1390 1400 1410 1420 1430 1440 pF1KA1 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG 1350 1360 1370 1380 1390 1400 1450 1460 1470 1480 1490 1500 pF1KA1 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG 1410 1420 1430 1440 1450 1460 1510 1520 1530 1540 1550 1560 pF1KA1 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI 1470 1480 1490 1500 1510 1520 1570 1580 1590 1600 1610 1620 pF1KA1 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT 1530 1540 1550 1560 1570 1580 1630 1640 1650 1660 1670 1680 pF1KA1 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI 1590 1600 1610 1620 1630 1640 1690 1700 1710 1720 1730 1740 pF1KA1 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ 1650 1660 1670 1680 1690 1700 1750 1760 1770 1780 1790 1800 pF1KA1 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG 1710 1720 1730 1740 1750 1760 1810 1820 1830 1840 1850 1860 pF1KA1 GACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT 1770 1780 1790 1800 1810 1820 1870 1880 1890 1900 1910 1920 pF1KA1 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1830 1840 1850 1860 1870 1880 1930 1940 1950 1960 1970 1980 pF1KA1 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC 1890 1900 1910 1920 1930 1940 1990 2000 2010 2020 2030 2040 pF1KA1 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC 1950 1960 1970 1980 1990 2000 2050 2060 2070 2080 2090 2100 pF1KA1 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC 2010 2020 2030 2040 2050 2060 2110 2120 2130 2140 2150 2160 pF1KA1 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL 2070 2080 2090 2100 2110 2120 2170 2180 2190 2200 2210 2220 pF1KA1 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA 2130 2140 2150 2160 2170 2180 2230 2240 2250 2260 2270 2280 pF1KA1 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD 2190 2200 2210 2220 2230 2240 2290 2300 2310 2320 2330 2340 pF1KA1 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP 2250 2260 2270 2280 2290 2300 2350 2360 2370 2380 2390 2400 pF1KA1 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA 2310 2320 2330 2340 2350 2360 2410 2420 2430 2440 2450 2460 pF1KA1 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL 2370 2380 2390 2400 2410 2420 2470 2480 2490 2500 2510 2520 pF1KA1 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV 2430 2440 2450 2460 2470 2480 2530 2540 2550 2560 2570 2580 pF1KA1 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG 2490 2500 2510 2520 2530 2540 2590 2600 2610 2620 2630 2640 pF1KA1 SASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: XP_016 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY 2550 2560 2570 2580 2590 2600 2650 2660 2670 2680 2690 2700 pF1KA1 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA 2610 2620 2630 2640 2650 2660 2710 2720 2730 2740 2750 2760 pF1KA1 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS 2670 2680 2690 2700 2710 2720 2770 2780 2790 2800 pF1KA1 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL 2730 2740 2750 2760 2770 >>XP_016882868 (OMIM: 608529) PREDICTED: fibrillin-3 iso (2851 aa) initn: 19383 init1: 19383 opt: 19503 Z-score: 12560.2 bits: 2338.6 E(85289): 0 Smith-Waterman score: 21297; 98.4% identity (98.5% similar) in 2841 aa overlap (11-2809:11-2851) 10 20 30 40 50 60 pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI 190 200 210 220 230 240 250 260 270 280 pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACED----------- ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDVNECLSLSGLC 250 260 270 280 290 300 290 300 310 pF1KA1 -------------------------------YRAGACFSVLFGGRCAGDLAGHYTRRQCC ::::::::::::::::::::::::::::: XP_016 SGGDCTNTVGSYVCTCSQGFASSLDGTHCLNYRAGACFSVLFGGRCAGDLAGHYTRRQCC 310 320 330 340 350 360 320 330 340 350 360 370 pF1KA1 CDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPA 370 380 390 400 410 420 380 390 400 410 420 430 pF1KA1 RLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVG 430 440 450 460 470 480 440 450 460 470 480 490 pF1KA1 YTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGG 490 500 510 520 530 540 500 510 520 530 540 550 pF1KA1 LCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCK 550 560 570 580 590 600 560 570 580 590 600 610 pF1KA1 PGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRS 610 620 630 640 650 660 620 630 640 650 660 670 pF1KA1 TCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKNSAEFQALCSSGLGITT :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: XP_016 TCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITT 670 680 690 700 710 720 680 690 700 710 720 730 pF1KA1 DGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNG 730 740 750 760 770 780 740 750 760 770 780 790 pF1KA1 WCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLD 790 800 810 820 830 840 800 810 820 830 840 850 pF1KA1 PSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARG 850 860 870 880 890 900 860 870 880 890 900 910 pF1KA1 FARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCF 910 920 930 940 950 960 920 930 940 950 960 970 pF1KA1 LRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFL 970 980 990 1000 1010 1020 980 990 1000 1010 1020 1030 pF1KA1 SGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDL 1030 1040 1050 1060 1070 1080 1040 1050 1060 1070 1080 1090 pF1KA1 CGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQC 1090 1100 1110 1120 1130 1140 1100 1110 1120 1130 1140 1150 pF1KA1 PPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINE 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 1210 pF1KA1 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGG 1210 1220 1230 1240 1250 1260 1220 1230 1240 1250 1260 1270 pF1KA1 HRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGC 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KA1 SDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECISQEHRCSPRGDC :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: XP_016 SDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDC 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KA1 LNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTED 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KA1 HRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCING :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCING 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KA1 VCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRAS 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 1560 1570 pF1KA1 CCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGD 1570 1580 1590 1600 1610 1620 1580 1590 1600 1610 1620 1630 pF1KA1 CVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQ 1630 1640 1650 1660 1670 1680 1640 1650 1660 1670 1680 1690 pF1KA1 VNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPD 1690 1700 1710 1720 1730 1740 1700 1710 1720 1730 1740 1750 pF1KA1 YQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSIL 1750 1760 1770 1780 1790 1800 1760 1770 1780 1790 1800 1810 pF1KA1 LACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGQNECREIPNVCSH :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: XP_016 LACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSH 1810 1820 1830 1840 1850 1860 1820 1830 1840 1850 1860 1870 pF1KA1 GDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVV 1870 1880 1890 1900 1910 1920 1880 1890 1900 1910 1920 1930 pF1KA1 THNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 THNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAG 1930 1940 1950 1960 1970 1980 1940 1950 1960 1970 1980 1990 pF1KA1 TCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPP 1990 2000 2010 2020 2030 2040 2000 2010 2020 2030 2040 2050 pF1KA1 GFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQ 2050 2060 2070 2080 2090 2100 2060 2070 2080 2090 2100 2110 pF1KA1 EGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLD 2110 2120 2130 2140 2150 2160 2120 2130 2140 2150 2160 2170 pF1KA1 FTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCA 2170 2180 2190 2200 2210 2220 2180 2190 2200 2210 2220 2230 pF1KA1 FRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPP 2230 2240 2250 2260 2270 2280 2240 2250 2260 2270 2280 2290 pF1KA1 GMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQG 2290 2300 2310 2320 2330 2340 2300 2310 2320 2330 2340 2350 pF1KA1 PCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYT 2350 2360 2370 2380 2390 2400 2360 2370 2380 2390 2400 2410 pF1KA1 AEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTF 2410 2420 2430 2440 2450 2460 2420 2430 2440 2450 2460 2470 pF1KA1 LCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQ 2470 2480 2490 2500 2510 2520 2480 2490 2500 2510 2520 2530 pF1KA1 HHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRC 2530 2540 2550 2560 2570 2580 2540 2550 2560 2570 2580 2590 pF1KA1 QHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSG 2590 2600 2610 2620 2630 2640 2600 2610 2620 2630 2640 2650 pF1KA1 FDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGP :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGP 2650 2660 2670 2680 2690 2700 2660 2670 2680 2690 2700 2710 pF1KA1 QDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLATLDSEALLTLGLNLSHLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLATLDSEALLTLGLNLSHLG 2710 2720 2730 2740 2750 2760 2720 2730 2740 2750 2760 2770 pF1KA1 RAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSSLQLGRRRPGPGTYRLEVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSSLQLGRRRPGPGTYRLEVV 2770 2780 2790 2800 2810 2820 2780 2790 2800 pF1KA1 SHMAGPWGVQPEGQPGPWGQALRLKVQLQLL ::::::::::::::::::::::::::::::: XP_016 SHMAGPWGVQPEGQPGPWGQALRLKVQLQLL 2830 2840 2850 >>XP_016882865 (OMIM: 608529) PREDICTED: fibrillin-3 iso (2766 aa) initn: 14479 init1: 14479 opt: 15802 Z-score: 10178.8 bits: 1897.9 E(85289): 0 Smith-Waterman score: 21031; 98.3% identity (98.5% similar) in 2809 aa overlap (1-2809:1-2766) 10 20 30 40 50 60 pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA1 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA1 DLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA1 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA1 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KA1 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KA1 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KA1 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KA1 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 pF1KA1 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 pF1KA1 GACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 pF1KA1 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL :::::::::::::::::::::::::: XP_016 CKNIIGSYNCLCFPGFVVTHNGDCVD---------------------------------- 1870 1880 1930 1940 1950 1960 1970 1980 pF1KA1 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ---------TNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC 1890 1900 1910 1920 1930 1990 2000 2010 2020 2030 2040 pF1KA1 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC 1940 1950 1960 1970 1980 1990 2050 2060 2070 2080 2090 2100 pF1KA1 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC 2000 2010 2020 2030 2040 2050 2110 2120 2130 2140 2150 2160 pF1KA1 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL 2060 2070 2080 2090 2100 2110 2170 2180 2190 2200 2210 2220 pF1KA1 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA 2120 2130 2140 2150 2160 2170 2230 2240 2250 2260 2270 2280 pF1KA1 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD 2180 2190 2200 2210 2220 2230 2290 2300 2310 2320 2330 2340 pF1KA1 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP 2240 2250 2260 2270 2280 2290 2350 2360 2370 2380 2390 2400 pF1KA1 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA 2300 2310 2320 2330 2340 2350 2410 2420 2430 2440 2450 2460 pF1KA1 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL 2360 2370 2380 2390 2400 2410 2470 2480 2490 2500 2510 2520 pF1KA1 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV 2420 2430 2440 2450 2460 2470 2530 2540 2550 2560 2570 2580 pF1KA1 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG 2480 2490 2500 2510 2520 2530 2590 2600 2610 2620 2630 2640 pF1KA1 SASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: XP_016 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY 2540 2550 2560 2570 2580 2590 2650 2660 2670 2680 2690 2700 pF1KA1 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA 2600 2610 2620 2630 2640 2650 2710 2720 2730 2740 2750 2760 pF1KA1 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS 2660 2670 2680 2690 2700 2710 2770 2780 2790 2800 pF1KA1 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL 2720 2730 2740 2750 2760 >>XP_016882862 (OMIM: 608529) PREDICTED: fibrillin-3 iso (2789 aa) initn: 21271 init1: 15632 opt: 15655 Z-score: 10084.1 bits: 1880.4 E(85289): 0 Smith-Waterman score: 21235; 99.1% identity (99.3% similar) in 2809 aa overlap (1-2809:1-2789) 10 20 30 40 50 60 pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA1 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA1 DLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA1 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA1 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KA1 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KA1 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KA1 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KA1 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 pF1KA1 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 pF1KA1 GACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 pF1KA1 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 pF1KA1 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 pF1KA1 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC 1990 2000 2010 2020 2030 2040 2050 2060 2070 2080 2090 2100 pF1KA1 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC :. :::::::::::::::::::::::::::::::::::::: XP_016 CT--------------------AFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC 2050 2060 2070 2080 2110 2120 2130 2140 2150 2160 pF1KA1 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL 2090 2100 2110 2120 2130 2140 2170 2180 2190 2200 2210 2220 pF1KA1 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA 2150 2160 2170 2180 2190 2200 2230 2240 2250 2260 2270 2280 pF1KA1 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD 2210 2220 2230 2240 2250 2260 2290 2300 2310 2320 2330 2340 pF1KA1 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP 2270 2280 2290 2300 2310 2320 2350 2360 2370 2380 2390 2400 pF1KA1 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA 2330 2340 2350 2360 2370 2380 2410 2420 2430 2440 2450 2460 pF1KA1 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL 2390 2400 2410 2420 2430 2440 2470 2480 2490 2500 2510 2520 pF1KA1 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV 2450 2460 2470 2480 2490 2500 2530 2540 2550 2560 2570 2580 pF1KA1 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG 2510 2520 2530 2540 2550 2560 2590 2600 2610 2620 2630 2640 pF1KA1 SASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: XP_016 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY 2570 2580 2590 2600 2610 2620 2650 2660 2670 2680 2690 2700 pF1KA1 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA 2630 2640 2650 2660 2670 2680 2710 2720 2730 2740 2750 2760 pF1KA1 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS 2690 2700 2710 2720 2730 2740 2770 2780 2790 2800 pF1KA1 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL 2750 2760 2770 2780 >>XP_016864717 (OMIM: 121050,612570,616118) PREDICTED: f (2861 aa) initn: 12727 init1: 7367 opt: 15312 Z-score: 9863.3 bits: 1839.6 E(85289): 0 Smith-Waterman score: 15396; 67.3% identity (86.5% similar) in 2811 aa overlap (39-2808:68-2860) 10 20 30 40 50 60 pF1KA1 ARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYC :: .::::::. .:.::::::::::.:: XP_016 PRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLRGPNVCGSRFHSYC 40 50 60 70 80 90 70 80 90 100 110 120 pF1KA1 CPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGG ::::.:.:: .::.::::: .::.::::.::.:::..: .. .:: . . ::: ::::: XP_016 CPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGG 100 110 120 130 140 150 130 140 150 160 170 180 pF1KA1 TCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCF :: : ::::: :: ::::.:. ::.::::::::::::::::: :::::::::::::: XP_016 TCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCF 160 170 180 190 200 210 190 200 210 220 230 240 pF1KA1 GQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDV ::. . :: ::::.::::.:::::.::::: :::.:::::.::::::::::.::::::: XP_016 TQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDV 220 230 240 250 260 270 250 260 270 280 290 300 pF1KA1 DECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFG----GRC :::::.::.::::.:.: ::::.::::.::. :... ::: : :.. : :.: XP_016 DECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCED--IDEC-SIIPGICETGEC 280 290 300 310 320 330 310 320 330 340 350 360 pF1KA1 AGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPL--LPGHPGLFPG .. ..... : : :: : : .:...:: . ::. .:: : :: XP_016 SNTVGSYF----CVCPRGY------VTSTDGSRCIEEYRRLCMDGLPMGGIPGSAGSRPG 340 350 360 370 380 370 380 390 400 pF1KA1 LLGFGSNGMGPPLGPARLNPHGSDARGIP-----SLGPGNSNIGTA----------TLNQ : :.::..: . .: :. :: : : :....:.. ::: XP_016 --GTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQ 390 400 410 420 430 440 410 420 430 440 450 460 pF1KA1 TIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIP :::::.: .::::::::.:: ::::::::.:: ::. :.:::::::::.:: .::::: : XP_016 TIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNGDCVNTP 450 460 470 480 490 500 470 480 490 500 510 520 pF1KA1 GTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGK :.:.:.:. ::: :::.:::.:.:::: .: ::. ::::::.:::::.:::::::. ::: XP_016 GSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGK 510 520 530 540 550 560 530 540 550 560 570 580 pF1KA1 NCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHC :::::.::.:..::.::.:.::::::.:.:::::.:::.:.:: :.:::::::::.:::: XP_016 NCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHC 570 580 590 600 610 620 590 600 610 620 630 640 pF1KA1 TNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANP :.::::::.: ::::: :::::::::.::::::.:.:: :.:::::.::::::::::: XP_016 INSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANP 630 640 650 660 670 680 650 660 670 680 690 700 pF1KA1 DHGFGEPCQLCPAKNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRC :.::::::: :::::::::..:::::.:::.::::::::::::..::::.:::::::::: XP_016 DYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRC 690 700 710 720 730 740 710 720 730 740 750 760 pF1KA1 VCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDV :: ::: :::..: :.::: .: :::::: :.:.::::::.::::. : .:: :.:. XP_016 NCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDI 750 760 770 780 790 800 770 780 790 800 810 820 pF1KA1 DECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQG .:: :.:::.:.::: ::..:.:.:::.:. .: .:.:: ::::::.::.::::::..: XP_016 NECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNING 810 820 830 840 850 860 830 840 850 860 870 880 pF1KA1 ASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVN :.:.:::::::::::::::::::.: :: ::.::. ::::.:::::: :::::::::::: XP_016 ATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVN 870 880 890 900 910 920 890 900 910 920 930 940 pF1KA1 TAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVW . :::.::::::: ::..::.:.:.:.: :.:.:::::: .:::.:::.:::..::.: XP_016 SKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAW 930 940 950 960 970 980 950 960 970 980 990 1000 pF1KA1 GVECEACPDPESLEFASLCPRGLGFASR-DFLSGRPFYKDVNECKVFPGLCTHGTCRNTV :.::: :: : . :. .::::: :::.: : :.:::::::.::::.:::.::.: ::::. XP_016 GTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTI 990 1000 1010 1020 1030 1040 1010 1020 1030 1040 1050 1060 pF1KA1 GSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLM :::.: : .::::: .::::::::::::::::::.: ::::::::::::: :::::::.: XP_016 GSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMM 1050 1060 1070 1080 1090 1100 1070 1080 1090 1100 1110 1120 pF1KA1 KNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPH :::::.::: :.:::::::::.::.::..:.:: ::::. . : ::.::::::.:: . XP_016 KNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRN 1110 1120 1130 1140 1150 1160 1130 1140 1150 1160 1170 1180 pF1KA1 GQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYS :.:::.::..::::. :.:.:::::::.::.:: ..:::::..: :.::::.:::..::. XP_016 GKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYA 1170 1180 1190 1200 1210 1220 1190 1200 1210 1220 1230 1240 pF1KA1 LMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNP ::::::.:::.::::.:: .:: :.:::.:: .::::::::::. ::.::.::.::::: XP_016 LMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNS 1230 1240 1250 1260 1270 1280 1250 1260 1270 1280 1290 1300 pF1KA1 HICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSC .::. :.::::::::.::::::: :.::.:::.::::::.:.:::: :::::::::::.: XP_016 NICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKC 1290 1300 1310 1320 1330 1340 1310 1320 1330 1340 1350 1360 pF1KA1 RCLPGWVGDGFECHDLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDEC : ::.:.:..: ::::: . :.:: ..:.:.::::::.: .::.:::: : : ::: XP_016 SCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDEC 1350 1360 1370 1380 1390 1400 1370 1380 1390 1400 1410 1420 pF1KA1 AENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMF :::..::.::::::.::.::::::::: :. : :.:::.:::. :.:.::.:.:::::: XP_016 AENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMF 1410 1420 1430 1440 1450 1460 1430 1440 1450 1460 1470 1480 pF1KA1 RCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVD .:::. :::::: :::::::.:::::.::.::.:.:::: : :.:: ::.:::.:::::: XP_016 HCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVD 1470 1480 1490 1500 1510 1520 1490 1500 1510 1520 1530 1540 pF1KA1 TRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLC .:.:::.:. :::...::..::::::.:.:::::::.::::::: :: .:.::: ::: XP_016 NRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLC 1530 1540 1550 1560 1570 1580 1550 1560 1570 1580 1590 1600 pF1KA1 PGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDI ::::::.:: ::.::::::::::::::::::.:.::::::::::: ::.::: ::::::: XP_016 PGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDI 1590 1600 1610 1620 1630 1640 1610 1620 1630 1640 1650 1660 pF1KA1 DECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGT-CQNEL ::: .: :.:::::::::::::::.:: ::.:::::.:::::::: :.: :::: :.::: XP_016 DECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENEL 1650 1660 1670 1680 1690 1700 1670 1680 1690 1700 1710 1720 pF1KA1 AFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDEC ::::..::::.::.:.:::.::: :::: . :.. .::: ::: :::::: .::::: XP_016 PFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGN-IPGFTFDIHTGKAVDIDEC 1710 1720 1730 1740 1750 1760 1730 1740 1750 1760 1770 1780 pF1KA1 GEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPG :::.:::::.:::::::::::::.::.::..::.:::.:::.. .. ::.:::::: :: XP_016 KEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPG 1770 1780 1790 1800 1810 1820 1790 1800 1810 1820 1830 1840 pF1KA1 SYRCKCTRGYKLSPGGACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLC ::::.:. :.::::.:::: .::: ::::::::: :.: .:::.:.:: ::.:: :::.: XP_016 SYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMC 1830 1840 1850 1860 1870 1880 1850 1860 1870 1880 1890 1900 pF1KA1 MDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLN ::.:::.:.::::::::: .:::::::.::: .:::.::.:.:::... ::::: :.:.: XP_016 MDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFN 1890 1900 1910 1920 1930 1940 1910 1920 1930 1940 1950 1960 pF1KA1 TAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD :::.:::..:.::: :::::.:::::..: :.: ::::::::::::::::::..:.:. XP_016 EIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSE 1950 1960 1970 1980 1990 2000 1970 1980 1990 2000 2010 2020 pF1KA1 HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGK .::::.::.:.::.::::.:::.::.:::::::::::::::.:::::::::::: :: :: XP_016 NCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGK 2010 2020 2030 2040 2050 2060 2030 2040 2050 2060 2070 2080 pF1KA1 CSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDV :::::::::::..::::: :::::::::::::.. .:::.:::.:::.::. :.:::: XP_016 CSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDV 2070 2080 2090 2100 2110 2120 2090 2100 2110 2120 2130 2140 pF1KA1 NECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVI ::: :.::.:.:: :.:::::::::::.::.::.::. ::::::::.:.:::.::::::: XP_016 NECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVI 2130 2140 2150 2160 2170 2180 2150 2160 2170 2180 2190 2200 pF1KA1 GGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMC :.::: : .::::: ::.::::.::. ::::::::: :: ::: :::: ::.:::: :: XP_016 GSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMC 2190 2200 2210 2220 2230 2240 2210 2220 2230 2240 2250 2260 pF1KA1 RDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVN .:.::::.: .::..::: :::::::: :.::::: : .::::.:.:::...: .: : XP_016 KDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRP-DGEGCVDENECRTKPGICEN 2250 2260 2270 2280 2290 2300 2270 2280 2290 2300 2310 2320 pF1KA1 GRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECC ::::: ::.::.:.:::: : . ::: : ::: ::::::::.:. ::: . ::..::: XP_016 GRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECC 2310 2320 2330 2340 2350 2360 2330 2340 2350 2360 2370 2380 pF1KA1 CGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGS : :::::: .:::::::::. :.:.:::: :::..:::.:::... .::..:.:::..:: XP_016 CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGS 2370 2380 2390 2400 2410 2420 2390 2400 2410 2420 2430 2440 pF1KA1 FRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCK ::: :..::: : ..:.:.:.::::: ::::...::::.::. :::::::.:.:::.::: XP_016 FRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCK 2430 2440 2450 2460 2470 2480 2450 2460 2470 2480 2490 2500 pF1KA1 DLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNT ::::: ..:::::::::::.:.:::.::::::::: ::.::.::..::. :::.: :.:: XP_016 DLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNT 2490 2500 2510 2520 2530 2540 2510 2520 2530 2540 2550 2560 pF1KA1 PGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQ :::: :::..::.: ..: .::::.:::: ::::::::: ::::::.::::. :: :: : XP_016 PGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQ 2550 2560 2570 2580 2590 2600 2570 2580 2590 2600 2610 2620 pF1KA1 CVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSC :::::::. .: .:::::: ::::...:.:::::.::: ..:.::.::.. ..::.:.: XP_016 CVDENECS-NPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGC 2610 2620 2630 2640 2650 2630 2640 2650 2660 2670 2680 pF1KA1 ANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ---DTP-DKEELLSSEACYECKINGL .:: ::.::::: ::.:.::::::::.::. : :: :.:. :: :::::::::: XP_016 SNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEACYECKINGY 2660 2670 2680 2690 2700 2710 2690 2700 2710 2720 2730 pF1KA1 SPRD-RPRRSAHRD-----HQVNLATLDSEALLTLGLNLSHLGRAERILELRPALEGLEG : .: : .:: :. .:..: ..: .. ... .:::::: :.:::::::.. :.. XP_016 SKKDSRQKRSIHEPDPTAVEQISLESVDMDSPVNMKFNLSHLGSKEHILELRPAIQPLNN 2720 2730 2740 2750 2760 2770 2740 2750 2760 2770 2780 2790 pF1KA1 RIRYVIVRGNEQGFFRMHHLRGVSSLQLGRRRPGPGTYRLEVVS---HMAGPWGVQPEGQ .::::: .::... ::.:. :.: :. .... :::: ::..: . :.. XP_016 HIRYVISQGNDDSVFRIHQRNGLSYLHTAKKKLMPGTYTLEITSIPLYKKKELKKLEESN 2780 2790 2800 2810 2820 2830 2800 pF1KA1 P-----GPWGQALRLKVQLQLL : :.:::...:.:: XP_016 EDDYLLGELGEALRMRLQIQLY 2840 2850 2860 >>XP_016882866 (OMIM: 608529) PREDICTED: fibrillin-3 iso (1948 aa) initn: 14885 init1: 14885 opt: 14885 Z-score: 9590.4 bits: 1788.5 E(85289): 0 Smith-Waterman score: 14885; 99.8% identity (100.0% similar) in 1948 aa overlap (862-2809:1-1948) 840 850 860 870 880 890 pF1KA1 SECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGS :::::::::::::::::::::::::::::: XP_016 MTGVTCDDVNECESFPGVCPNGRCVNTAGS 10 20 30 900 910 920 930 940 950 pF1KA1 FRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVEC 40 50 60 70 80 90 960 970 980 990 1000 1010 pF1KA1 EACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHC 100 110 120 130 140 150 1020 1030 1040 1050 1060 1070 pF1KA1 ACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMD 160 170 180 190 200 210 1080 1090 1100 1110 1120 1130 pF1KA1 VDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVN 220 230 240 250 260 270 1140 1150 1160 1170 1180 1190 pF1KA1 VIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDG 280 290 300 310 320 330 1200 1210 1220 1230 1240 1250 pF1KA1 RACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLH 340 350 360 370 380 390 1260 1270 1280 1290 1300 1310 pF1KA1 GDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPG 400 410 420 430 440 450 1320 1330 1340 1350 1360 1370 pF1KA1 WVGDGFECHDLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVD ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_016 WVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVD 460 470 480 490 500 510 1380 1390 1400 1410 1420 1430 pF1KA1 LCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICN 520 530 540 550 560 570 1440 1450 1460 1470 1480 1490 pF1KA1 GGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGN 580 590 600 610 620 630 1500 1510 1520 1530 1540 1550 pF1KA1 CFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEG 640 650 660 670 680 690 1560 1570 1580 1590 1600 1610 pF1KA1 FQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECST 700 710 720 730 740 750 1620 1630 1640 1650 1660 1670 pF1KA1 HSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTR 760 770 780 790 800 810 1680 1690 1700 1710 1720 1730 pF1KA1 KMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAI 820 830 840 850 860 870 1740 1750 1760 1770 1780 1790 pF1KA1 CANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKC 880 890 900 910 920 930 1800 1810 1820 1830 1840 1850 pF1KA1 TRGYKLSPGGACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDEC ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDEC 940 950 960 970 980 990 1860 1870 1880 1890 1900 1910 pF1KA1 DRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFH 1000 1010 1020 1030 1040 1050 1920 1930 1940 1950 1960 1970 pF1KA1 CLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDID 1060 1070 1080 1090 1100 1110 1980 1990 2000 2010 2020 2030 pF1KA1 ECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKA 1120 1130 1140 1150 1160 1170 2040 2050 2060 2070 2080 2090 pF1KA1 FNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAEN 1180 1190 1200 1210 1220 1230 2100 2110 2120 2130 2140 2150 pF1KA1 PGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECA 1240 1250 1260 1270 1280 1290 2160 2170 2180 2190 2200 2210 pF1KA1 CADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDEC 1300 1310 1320 1330 1340 1350 2220 2230 2240 2250 2260 2270 pF1KA1 ADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNT 1360 1370 1380 1390 1400 1410 2280 2290 2300 2310 2320 2330 pF1KA1 AGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRG 1420 1430 1440 1450 1460 1470 2340 2350 2360 2370 2380 2390 pF1KA1 WGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQ 1480 1490 1500 1510 1520 1530 2400 2410 2420 2430 2440 2450 pF1KA1 AGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECT 1540 1550 1560 1570 1580 1590 2460 2470 2480 2490 2500 2510 pF1KA1 SRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRC 1600 1610 1620 1630 1640 1650 2520 2530 2540 2550 2560 2570 pF1KA1 ECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENE 1660 1670 1680 1690 1700 1710 2580 2590 2600 2610 2620 2630 pF1KA1 CALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGG ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: XP_016 CALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGG 1720 1730 1740 1750 1760 1770 2640 2650 2660 2670 2680 2690 pF1KA1 FLCGCPQGYFRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLCGCPQGYFRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSA 1780 1790 1800 1810 1820 1830 2700 2710 2720 2730 2740 2750 pF1KA1 HRDHQVNLATLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRDHQVNLATLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFR 1840 1850 1860 1870 1880 1890 2760 2770 2780 2790 2800 pF1KA1 MHHLRGVSSLQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MHHLRGVSSLQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL 1900 1910 1920 1930 1940 >>NP_001990 (OMIM: 121050,612570,616118) fibrillin-2 pre (2912 aa) initn: 12727 init1: 7367 opt: 14009 Z-score: 9024.8 bits: 1684.4 E(85289): 0 Smith-Waterman score: 15541; 67.1% identity (85.9% similar) in 2849 aa overlap (39-2808:68-2911) 10 20 30 40 50 60 pF1KA1 ARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYC :: .::::::. .:.::::::::::.:: NP_001 PRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLRGPNVCGSRFHSYC 40 50 60 70 80 90 70 80 90 100 110 120 pF1KA1 CPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGG ::::.:.:: .::.::::: .::.::::.::.:::..: .. .:: . . ::: ::::: NP_001 CPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGG 100 110 120 130 140 150 130 140 150 160 170 180 pF1KA1 TCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCF :: : ::::: :: ::::.:. ::.::::::::::::::::: :::::::::::::: NP_001 TCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCF 160 170 180 190 200 210 190 200 210 220 230 240 pF1KA1 GQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDV ::. . :: ::::.::::.:::::.::::: :::.:::::.::::::::::.::::::: NP_001 TQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDV 220 230 240 250 260 270 250 260 270 280 290 pF1KA1 DECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDY------------------ :::::.::.::::.:.: ::::.::::.::. :... ::: NP_001 DECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNT 280 290 300 310 320 330 300 310 320 pF1KA1 ------------------------RAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWA :.: ::: : .:::: .: :..:. ::::. ::::. NP_001 VGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWG 340 350 360 370 380 390 330 340 350 360 370 380 pF1KA1 AGPVPELCPPRGSNEFQQLCAQRLPL--LPGHPGLFPGLLGFGSNGMGPPLGPARLNPHG : .:: :: :::.:...:: . ::. .:: : :: : :.::..: . .: : NP_001 IGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPG--GTGGNGFAPSGNGNGYGPGG 400 410 420 430 440 450 390 400 410 420 pF1KA1 SDARGIP-----SLGPGNSNIGTA----------TLNQTIDICRHFTNLCLNGRCLPTPS . :: : : :....:.. ::::::::.: .::::::::.:: : NP_001 TGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVS 460 470 480 490 500 510 430 440 450 460 470 480 pF1KA1 SYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVD :::::::.:: ::. :.:::::::::.:: .::::: ::.:.:.:. ::: :::.:::.: NP_001 SYRCECNMGYKQDANGDCIDVDECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACID 520 530 540 550 560 570 490 500 510 520 530 540 pF1KA1 VDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNE .:::: .: ::. ::::::.:::::.:::::::. ::::::::.::.:..::.::.:.:: NP_001 IDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINE 580 590 600 610 620 630 550 560 570 580 590 600 pF1KA1 DGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGR ::::.:.:::::.:::.:.:: :.:::::::::.:::: :.::::::.: ::::: ::: NP_001 DGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGR 640 650 660 670 680 690 610 620 630 640 650 660 pF1KA1 VCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKNSAEFQAL ::::::.::::::.:.:: :.:::::.::::::::::::.::::::: :::::::::..: NP_001 VCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGL 700 710 720 730 740 750 670 680 690 700 710 720 pF1KA1 CSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECA ::::.:::.::::::::::::..::::.:::::::::: :: ::: :::..: :.::: NP_001 CSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL 760 770 780 790 800 810 730 740 750 760 770 780 pF1KA1 LNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTC .: :::::: :.:.::::::.::::. : .:: :.:..:: :.:::.:.::: ::..: NP_001 VNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNC 820 830 840 850 860 870 790 800 810 820 830 840 pF1KA1 KCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERC .:.:::.:. .: .:.:: ::::::.::.::::::..::.:.:::::::::::::::::: NP_001 ECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERC 880 890 900 910 920 930 850 860 870 880 890 900 pF1KA1 EIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLC :.: :: ::.::. ::::.:::::: ::::::::::::. :::.::::::: ::..::.: NP_001 ELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVC 940 950 960 970 980 990 910 920 930 940 950 960 pF1KA1 VDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRG .:.:.: :.:.:::::: .:::.:::.:::..::.::.::: :: : . :. .::::: NP_001 LDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRG 1000 1010 1020 1030 1040 1050 970 980 990 1000 1010 1020 pF1KA1 LGFASR-DFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTD :::.: : :.:::::::.::::.:::.::.: ::::.:::.: : .::::: .:::::: NP_001 AGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTD 1060 1070 1080 1090 1100 1110 1030 1040 1050 1060 1070 1080 pF1KA1 IDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCT ::::::::::::.: ::::::::::::: :::::::.::::::.::: :.:::::::::. NP_001 IDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCV 1120 1130 1140 1150 1160 1170 1090 1100 1110 1120 1130 1140 pF1KA1 NTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTP ::.::..:.:: ::::. . : ::.::::::.:: .:.:::.::..::::. :.:.:: NP_001 NTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATP 1180 1190 1200 1210 1220 1230 1150 1160 1170 1180 1190 1200 pF1KA1 DRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCD :::::.::.:: ..:::::..: :.::::.:::..::.::::::.:::.::::.:: .:: NP_001 DRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICD 1240 1250 1260 1270 1280 1290 1210 1220 1230 1240 1250 1260 pF1KA1 QGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLG :.:::.:: .::::::::::. ::.::.::.::::: .::. :.::::::::.:::::: NP_001 GGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLG 1300 1310 1320 1330 1340 1350 1270 1280 1290 1300 1310 1320 pF1KA1 YMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECISQ : :.::.:::.::::::.:.:::: :::::::::::.: : ::.:.:..: ::::: . NP_001 YSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNG 1360 1370 1380 1390 1400 1410 1330 1340 1350 1360 1370 1380 pF1KA1 EHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCE :.:: ..:.:.::::::.: .::.:::: : : ::::::..::.::::::.::.:::: NP_001 THQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCE 1420 1430 1440 1450 1460 1470 1390 1400 1410 1420 1430 1440 pF1KA1 CEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINE ::::: :. : :.:::.:::. :.:.::.:.::::::.:::. :::::: :::::::.: NP_001 CEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDE 1480 1490 1500 1510 1520 1530 1450 1460 1470 1480 1490 1500 pF1KA1 CADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSA ::::.::.::.:.:::: : :.:: ::.:::.::::::.:.:::.:. :::...::.. NP_001 CADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNT 1540 1550 1560 1570 1580 1590 1510 1520 1530 1540 1550 1560 pF1KA1 EIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQ ::::::.:.:::::::.::::::: :: .:.::: :::::::::.:: ::.::::::::: NP_001 EIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQ 1600 1610 1620 1630 1640 1650 1570 1580 1590 1600 1610 1620 pF1KA1 ELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNY :::::::::.:.::::::::::: ::.::: :::::::::: .: :.::::::::::::: NP_001 ELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNY 1660 1670 1680 1690 1700 1710 1630 1640 1650 1660 1670 1680 pF1KA1 TCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGT-CQNELAFNVTRKMCCCSYNIGQAWNRP ::.:: ::.:::::.:::::::: :.: :::: :.::: ::::..::::.::.:.:::.: NP_001 TCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKP 1720 1730 1740 1750 1760 1770 1690 1700 1710 1720 1730 1740 pF1KA1 CEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCE :: :::: . :.. .::: ::: :::::: .::::: :::.:::::.::::::::::: NP_001 CEPCPTPGTADFKTICGN-IPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCE 1780 1790 1800 1810 1820 1830 1750 1760 1770 1780 1790 1800 pF1KA1 CPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGQN ::.::.::..::.:::.:::.. .. ::.:::::: ::::::.:. :.::::.:::: .: NP_001 CPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRN 1840 1850 1860 1870 1880 1890 1810 1820 1830 1840 1850 1860 pF1KA1 ECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGS :: ::::::::: :.: .:::.:.:: ::.:: :::.:::.:::.:.::::::::: .:: NP_001 ECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGS 1900 1910 1920 1930 1940 1950 1870 1880 1890 1900 1910 1920 pF1KA1 YNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNC :::::.::: .:::.::.:.:::... ::::: :.:.: :::.:::..:.::: ::::: NP_001 YNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNC 1960 1970 1980 1990 2000 2010 1930 1940 1950 1960 1970 1980 pF1KA1 VDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTN .:::::..: :.: ::::::::::::::::::..:.:..::::.::.:.::.::::.::: NP_001 IDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTN 2020 2030 2040 2050 2060 2070 1990 2000 2010 2020 2030 2040 pF1KA1 SPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGE .::.:::::::::::::::.:::::::::::: :: :::::::::::::..::::: ::: NP_001 TPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGE 2080 2090 2100 2110 2120 2130 2050 2060 2070 2080 2090 2100 pF1KA1 GWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSF ::::::::::.. .:::.:::.:::.::. :.::::::: :.::.:.:: :.:::::: NP_001 GWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSF 2140 2150 2160 2170 2180 2190 2110 2120 2130 2140 2150 2160 pF1KA1 RCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDI :::::.::.::.::. ::::::::.:.:::.::::::::.::: : .::::: ::.:::: NP_001 RCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDI 2200 2210 2220 2230 2240 2250 2170 2180 2190 2200 2210 2220 pF1KA1 DECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKN .::. ::::::::: :: ::: :::: ::.:::: ::.:.::::.: .::..::: ::: NP_001 NECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKN 2260 2270 2280 2290 2300 2310 2230 2240 2250 2260 2270 2280 pF1KA1 LIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSP ::::: :.::::: : .::::.:.:::...: .: :::::: ::.::.:.:::: : NP_001 LIGTFMCICPPGMARRP-DGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSS 2320 2330 2340 2350 2360 2370 2290 2300 2310 2320 2330 2340 pF1KA1 TLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAY . ::: : ::: ::::::::.:. ::: . ::..:::: :::::: .:::::::::. : NP_001 SGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQY 2380 2390 2400 2410 2420 2430 2350 2360 2370 2380 2390 2400 pF1KA1 RKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMD .:.:::: :::..:::.:::... .::..:.:::..::::: :..::: : ..:.:.:.: NP_001 KKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLD 2440 2450 2460 2470 2480 2490 2410 2420 2430 2440 2450 2460 pF1KA1 ECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGA :::: ::::...::::.::. :::::::.:.:::.:::::::: ..:::::::::::.:. NP_001 ECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGG 2500 2510 2520 2530 2540 2550 2470 2480 2490 2500 2510 2520 pF1KA1 FTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE :::.::::::::: ::.::.::..::. :::.: :.:::::: :::..::.: ..: .:: NP_001 FTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCE 2560 2570 2580 2590 2600 2610 2530 2540 2550 2560 2570 2580 pF1KA1 DVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNT ::.:::: ::::::::: ::::::.::::. :: :: ::::::::. .: .:::::: :: NP_001 DVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECS-NPNACGSASCYNT 2620 2630 2640 2650 2660 2670 2590 2600 2610 2620 2630 2640 pF1KA1 LGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGH ::...:.:::::.::: ..:.::.::.. ..::.:.:.:: ::.::::: ::.:.:::: NP_001 LGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGH 2680 2690 2700 2710 2720 2730 2650 2660 2670 2680 2690 pF1KA1 CVSGLGFSPGPQ---DTP-DKEELLSSEACYECKINGLSPRD-RPRRSAHRD-----HQV ::::.::. : :: :.:. :: :::::::::: : .: : .:: :. .:. NP_001 CVSGMGFNKGQYLSLDTEVDEENALSPEACYECKINGYSKKDSRQKRSIHEPDPTAVEQI 2740 2750 2760 2770 2780 2790 2700 2710 2720 2730 2740 2750 pF1KA1 NLATLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRG .: ..: .. ... .:::::: :.:::::::.. :...::::: .::... ::.:. : NP_001 SLESVDMDSPVNMKFNLSHLGSKEHILELRPAIQPLNNHIRYVISQGNDDSVFRIHQRNG 2800 2810 2820 2830 2840 2850 2760 2770 2780 2790 2800 pF1KA1 VSSLQLGRRRPGPGTYRLEVVS---HMAGPWGVQPEGQP-----GPWGQALRLKVQLQLL .: :. .... :::: ::..: . :.. : :.:::...:.:: NP_001 LSYLHTAKKKLMPGTYTLEITSIPLYKKKELKKLEESNEDDYLLGELGEALRMRLQIQLY 2860 2870 2880 2890 2900 2910 2809 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 20:12:13 2016 done: Thu Nov 3 20:12:16 2016 Total Scan time: 17.850 Total Display time: 2.980 Function used was FASTA [36.3.4 Apr, 2011]