Result of FASTA (omim) for pF1KSDA0842
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA0842, 1019 aa
  1>>>pF1KSDA0842 1019 - 1019 aa - 1019 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.6072+/-0.000397; mu= 6.6747+/- 0.025
 mean_var=192.6076+/-39.082, 0's: 0 Z-trim(118.5): 22  B-trim: 39 in 2/55
 Lambda= 0.092414
 statistics sampled from 31486 (31508) to 31486 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.712), E-opt: 0.2 (0.369), width:  16
 Scan time: 17.170

The best scores are:                                      opt bits E(85289)
NP_055979 (OMIM: 609613) pleckstrin homology domai (1019) 6903 933.8       0
XP_016856246 (OMIM: 609613) PREDICTED: pleckstrin  (1032) 6780 917.4       0
XP_005245848 (OMIM: 609613) PREDICTED: pleckstrin  ( 816) 5472 742.9 1.6e-213
XP_005245847 (OMIM: 609613) PREDICTED: pleckstrin  ( 999) 5330 724.0 9.6e-208
XP_016856247 (OMIM: 609613) PREDICTED: pleckstrin  (1012) 5330 724.0 9.7e-208
XP_011523826 (OMIM: 611466,611497) PREDICTED: plec (1056)  240 45.4  0.0019
NP_055613 (OMIM: 611466,611497) pleckstrin homolog (1056)  240 45.4  0.0019
XP_016880940 (OMIM: 611466,611497) PREDICTED: plec (1056)  240 45.4  0.0019
XP_011523825 (OMIM: 611466,611497) PREDICTED: plec (1056)  240 45.4  0.0019
XP_016880941 (OMIM: 611466,611497) PREDICTED: plec ( 967)  223 43.1  0.0087
XP_011523827 (OMIM: 611466,611497) PREDICTED: plec (1005)  223 43.1   0.009


>>NP_055979 (OMIM: 609613) pleckstrin homology domain-co  (1019 aa)
 initn: 6903 init1: 6903 opt: 6903  Z-score: 4983.9  bits: 933.8 E(85289):    0
Smith-Waterman score: 6903; 100.0% identity (100.0% similar) in 1019 aa overlap (1-1019:1-1019)

               10        20        30        40        50        60
pF1KSD MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD HKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFED
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD RLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGD
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD LTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD LDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD GRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQ
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD LDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD HHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD EPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD FRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDY
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD VSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATM
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD EKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLHY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLHY
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD KAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD FQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFT
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD CHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 CHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDR
              910       920       930       940       950       960

              970       980       990      1000      1010         
pF1KSD LLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
              970       980       990      1000      1010         

>>XP_016856246 (OMIM: 609613) PREDICTED: pleckstrin homo  (1032 aa)
 initn: 6780 init1: 6780 opt: 6780  Z-score: 4895.2  bits: 917.4 E(85289):    0
Smith-Waterman score: 6780; 100.0% identity (100.0% similar) in 999 aa overlap (21-1019:34-1032)

                         10        20        30        40        50
pF1KSD           MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLD
                                     ::::::::::::::::::::::::::::::
XP_016 SCIQQVGACMHPSQDGVGRKCAILTPQTPLLQSYFAACEDEIPAIRNHDKVLQRLCEHLD
            10        20        30        40        50        60   

               60        70        80        90       100       110
pF1KSD HALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYL
            70        80        90       100       110       120   

              120       130       140       150       160       170
pF1KSD RLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYY
           130       140       150       160       170       180   

              180       190       200       210       220       230
pF1KSD KPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPS
           190       200       210       220       230       240   

              240       250       260       270       280       290
pF1KSD VPSTDWEDGDLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPSTDWEDGDLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHT
           250       260       270       280       290       300   

              300       310       320       330       340       350
pF1KSD TSQEKEEAQALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSQEKEEAQALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGD
           310       320       330       340       350       360   

              360       370       380       390       400       410
pF1KSD GDSRNGSPSLGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDSRNGSPSLGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPL
           370       380       390       400       410       420   

              420       430       440       450       460       470
pF1KSD SKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVE
           430       440       450       460       470       480   

              480       490       500       510       520       530
pF1KSD SPSTVTSGGGHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSTVTSGGGHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQ
           490       500       510       520       530       540   

              540       550       560       570       580       590
pF1KSD LSLVREGPVSEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSLVREGPVSEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDN
           550       560       570       580       590       600   

              600       610       620       630       640       650
pF1KSD NHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVE
           610       620       630       640       650       660   

              660       670       680       690       700       710
pF1KSD EAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPP
           670       680       690       700       710       720   

              720       730       740       750       760       770
pF1KSD YPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEG
           730       740       750       760       770       780   

              780       790       800       810       820       830
pF1KSD TITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCR
           790       800       810       820       830       840   

              840       850       860       870       880       890
pF1KSD RANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCC
           850       860       870       880       890       900   

              900       910       920       930       940       950
pF1KSD LVLTDDRLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVLTDDRLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVI
           910       920       930       940       950       960   

              960       970       980       990      1000      1010
pF1KSD YLSCTSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLSCTSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCR
           970       980       990      1000      1010      1020   

                
pF1KSD GRASRDPWC
       :::::::::
XP_016 GRASRDPWC
          1030  

>>XP_005245848 (OMIM: 609613) PREDICTED: pleckstrin homo  (816 aa)
 initn: 5472 init1: 5472 opt: 5472  Z-score: 3954.2  bits: 742.9 E(85289): 1.6e-213
Smith-Waterman score: 5472; 99.1% identity (99.4% similar) in 810 aa overlap (210-1019:7-816)

     180       190       200       210       220       230         
pF1KSD DRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDG
                                     :.    . ::::::::::::::::::::::
XP_005                         MVAPFASGTEEEAADYDFGDVFPAVPSVPSTDWEDG
                                       10        20        30      

     240       250       260       270       280       290         
pF1KSD DLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQ
         40        50        60        70        80        90      

     300       310       320       330       340       350         
pF1KSD ALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPS
        100       110       120       130       140       150      

     360       370       380       390       400       410         
pF1KSD LGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNG
        160       170       180       190       200       210      

     420       430       440       450       460       470         
pF1KSD QLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGG
        220       230       240       250       260       270      

     480       490       500       510       520       530         
pF1KSD GHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPV
        280       290       300       310       320       330      

     540       550       560       570       580       590         
pF1KSD SEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIH
        340       350       360       370       380       390      

     600       610       620       630       640       650         
pF1KSD VFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELD
        400       410       420       430       440       450      

     660       670       680       690       700       710         
pF1KSD YVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDAT
        460       470       480       490       500       510      

     720       730       740       750       760       770         
pF1KSD MEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLH
        520       530       540       550       560       570      

     780       790       800       810       820       830         
pF1KSD YKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPH
        580       590       600       610       620       630      

     840       850       860       870       880       890         
pF1KSD AFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLF
        640       650       660       670       680       690      

     900       910       920       930       940       950         
pF1KSD TCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELD
        700       710       720       730       740       750      

     960       970       980       990      1000      1010         
pF1KSD RLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
        760       770       780       790       800       810      

>>XP_005245847 (OMIM: 609613) PREDICTED: pleckstrin homo  (999 aa)
 initn: 5327 init1: 5327 opt: 5330  Z-score: 3850.6  bits: 724.0 E(85289): 9.6e-208
Smith-Waterman score: 6703; 98.0% identity (98.0% similar) in 1019 aa overlap (1-1019:1-999)

               10        20        30        40        50        60
pF1KSD MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD HKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFED
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD RLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGD
       ::::::::::::::::::::::::::::::::::::::                    ::
XP_005 RLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSED--------------------GD
              190       200       210                           220

              250       260       270       280       290       300
pF1KSD LTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQA
              230       240       250       260       270       280

              310       320       330       340       350       360
pF1KSD LDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSL
              290       300       310       320       330       340

              370       380       390       400       410       420
pF1KSD GRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQ
              350       360       370       380       390       400

              430       440       450       460       470       480
pF1KSD LDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGG
              410       420       430       440       450       460

              490       500       510       520       530       540
pF1KSD HHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVS
              470       480       490       500       510       520

              550       560       570       580       590       600
pF1KSD EPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHV
              530       540       550       560       570       580

              610       620       630       640       650       660
pF1KSD FRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDY
              590       600       610       620       630       640

              670       680       690       700       710       720
pF1KSD VSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATM
              650       660       670       680       690       700

              730       740       750       760       770       780
pF1KSD EKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLHY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLHY
              710       720       730       740       750       760

              790       800       810       820       830       840
pF1KSD KAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHA
              770       780       790       800       810       820

              850       860       870       880       890       900
pF1KSD FQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFT
              830       840       850       860       870       880

              910       920       930       940       950       960
pF1KSD CHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDR
              890       900       910       920       930       940

              970       980       990      1000      1010         
pF1KSD LLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
              950       960       970       980       990         

>>XP_016856247 (OMIM: 609613) PREDICTED: pleckstrin homo  (1012 aa)
 initn: 5327 init1: 5327 opt: 5330  Z-score: 3850.6  bits: 724.0 E(85289): 9.7e-208
Smith-Waterman score: 6580; 98.0% identity (98.0% similar) in 999 aa overlap (21-1019:34-1012)

                         10        20        30        40        50
pF1KSD           MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLD
                                     ::::::::::::::::::::::::::::::
XP_016 SCIQQVGACMHPSQDGVGRKCAILTPQTPLLQSYFAACEDEIPAIRNHDKVLQRLCEHLD
            10        20        30        40        50        60   

               60        70        80        90       100       110
pF1KSD HALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYL
            70        80        90       100       110       120   

              120       130       140       150       160       170
pF1KSD RLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYY
           130       140       150       160       170       180   

              180       190       200       210       220       230
pF1KSD KPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPS
       :::::::::::::::::::::::::::::::::::::::::::::::             
XP_016 KPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSE-------------
           190       200       210       220       230             

              240       250       260       270       280       290
pF1KSD VPSTDWEDGDLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHT
              :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -------DGDLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHT
                     240       250       260       270       280   

              300       310       320       330       340       350
pF1KSD TSQEKEEAQALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSQEKEEAQALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGD
           290       300       310       320       330       340   

              360       370       380       390       400       410
pF1KSD GDSRNGSPSLGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDSRNGSPSLGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPL
           350       360       370       380       390       400   

              420       430       440       450       460       470
pF1KSD SKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVE
           410       420       430       440       450       460   

              480       490       500       510       520       530
pF1KSD SPSTVTSGGGHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSTVTSGGGHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQ
           470       480       490       500       510       520   

              540       550       560       570       580       590
pF1KSD LSLVREGPVSEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSLVREGPVSEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDN
           530       540       550       560       570       580   

              600       610       620       630       640       650
pF1KSD NHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVE
           590       600       610       620       630       640   

              660       670       680       690       700       710
pF1KSD EAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPP
           650       660       670       680       690       700   

              720       730       740       750       760       770
pF1KSD YPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEG
           710       720       730       740       750       760   

              780       790       800       810       820       830
pF1KSD TITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCR
           770       780       790       800       810       820   

              840       850       860       870       880       890
pF1KSD RANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCC
           830       840       850       860       870       880   

              900       910       920       930       940       950
pF1KSD LVLTDDRLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVLTDDRLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVI
           890       900       910       920       930       940   

              960       970       980       990      1000      1010
pF1KSD YLSCTSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLSCTSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCR
           950       960       970       980       990      1000   

                
pF1KSD GRASRDPWC
       :::::::::
XP_016 GRASRDPWC
          1010  

>>XP_011523826 (OMIM: 611466,611497) PREDICTED: pleckstr  (1056 aa)
 initn: 247 init1: 199 opt: 240  Z-score: 182.7  bits: 45.4 E(85289): 0.0019
Smith-Waterman score: 270; 24.8% identity (49.3% similar) in 499 aa overlap (1-446:9-475)

                       10        20        30        40        50  
pF1KSD         MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHA
               ..:  .   : ...  ::: ::. ... .    .. ..:   . .:  :. .
XP_011 MLSVVENGLDPQAAIPVIKKKLVGSVKALQKQYVSLDT---VVTSEDGDANTMCSALEAV
               10        20        30           40        50       

                 60                        70        80        90  
pF1KSD LLYGLQD----LSSG----------------YWVLVVHFTRREAIKQIEVLQHVATNLGR
       ...::.       .:                .: :.   :... :...: :  : :..::
XP_011 FIHGLHAKHIRAEAGGKRKKSAHQKPLPQPVFWPLLKAVTHKHIISELEHLTFVNTDVGR
        60        70        80        90       100       110       

            100       110       120       130       140       150  
pF1KSD SRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFE
        :::: ::::.. .: ::.:. .. . ::.::  .::. . ..  ..:....::  . ::
XP_011 CRAWLRLALNDGLMECYLKLLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFE
       120       130       140       150       160       170       

            160          170       180       190       200         
pF1KSD LDLDAPYLD---LAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVT----STNL
       :.  .  :.   :.:   .   :   ::     : :. :..    .:..:..    : ..
XP_011 LSYKSAILNEWTLTPLALSGLCPLSELD-----PLSTSGAELQRKESLDSISHSSGSEDI
       180       190       200            210       220       230  

         210               220       230          240        250   
pF1KSD EWDDSA--------IAPSSEDYDFGDVFPAVPSVPSTD---WEDGDLT-DTVSGPRSTAS
       :   :.        .. :: . : ..      :. : .    :.:. . :    : :  :
XP_011 EVHHSGHKIRRNQKLTASSLSLDTASSSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDS
            240       250       260       270       280       290  

           260         270       280       290       300       310 
pF1KSD DLTSSKA--STRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELE
       :: ...:  : ::  .    :..  ...:      :..  ::: :    .  :.:   :.
XP_011 DLGTANAEDSDRSLQEVLLEFSKAQVNSV------PTNGLSQETE----IPTPQASLSLH
            300       310       320             330           340  

             320       330       340       350       360        370
pF1KSD VIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSP-DTMLA
                 : . ..    :: : .:  .:   . : ::  .   :     :: : .  
XP_011 ----------GLNTSTYLHCEA-PAEPLPAQAASGTQ-DG-VHVQEPRPQAPSPLDLQQP
                      350        360        370        380         

              380          390       400         410       420     
pF1KSD SPQEEGEGPSSTTESSER---SEPGLLIPEMKDTSMERL--GQPLSKVIDQLNGQLD---
         .  :. ::::.  . :   .  ::   . .: .  .:  ..: :    .  .. :   
XP_011 VESTSGQQPSSTVSETAREVGQGNGLQKAQAHDGAGLKLVVSSPTSPKNKSWISEDDFYR
     390       400       410       420       430       440         

               430       440       450       460       470         
pF1KSD PST---WCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGG
       ::      : .. :  :.: :.::. :                                 
XP_011 PSREQPLESASDHPIASYR-GTPGSRPGLHRHFSQEPRKNCSLGALDQACVPSPGRRQAQ
     450       460        470       480       490       500        

>>NP_055613 (OMIM: 611466,611497) pleckstrin homology do  (1056 aa)
 initn: 247 init1: 199 opt: 240  Z-score: 182.7  bits: 45.4 E(85289): 0.0019
Smith-Waterman score: 270; 24.8% identity (49.3% similar) in 499 aa overlap (1-446:9-475)

                       10        20        30        40        50  
pF1KSD         MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHA
               ..:  .   : ...  ::: ::. ... .    .. ..:   . .:  :. .
NP_055 MLSVVENGLDPQAAIPVIKKKLVGSVKALQKQYVSLDT---VVTSEDGDANTMCSALEAV
               10        20        30           40        50       

                 60                        70        80        90  
pF1KSD LLYGLQD----LSSG----------------YWVLVVHFTRREAIKQIEVLQHVATNLGR
       ...::.       .:                .: :.   :... :...: :  : :..::
NP_055 FIHGLHAKHIRAEAGGKRKKSAHQKPLPQPVFWPLLKAVTHKHIISELEHLTFVNTDVGR
        60        70        80        90       100       110       

            100       110       120       130       140       150  
pF1KSD SRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFE
        :::: ::::.. .: ::.:. .. . ::.::  .::. . ..  ..:....::  . ::
NP_055 CRAWLRLALNDGLMECYLKLLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFE
       120       130       140       150       160       170       

            160          170       180       190       200         
pF1KSD LDLDAPYLD---LAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVT----STNL
       :.  .  :.   :.:   .   :   ::     : :. :..    .:..:..    : ..
NP_055 LSYKSAILNEWTLTPLALSGLCPLSELD-----PLSTSGAELQRKESLDSISHSSGSEDI
       180       190       200            210       220       230  

         210               220       230          240        250   
pF1KSD EWDDSA--------IAPSSEDYDFGDVFPAVPSVPSTD---WEDGDLT-DTVSGPRSTAS
       :   :.        .. :: . : ..      :. : .    :.:. . :    : :  :
NP_055 EVHHSGHKIRRNQKLTASSLSLDTASSSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDS
            240       250       260       270       280       290  

           260         270       280       290       300       310 
pF1KSD DLTSSKA--STRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELE
       :: ...:  : ::  .    :..  ...:      :..  ::: :    .  :.:   :.
NP_055 DLGTANAEDSDRSLQEVLLEFSKAQVNSV------PTNGLSQETE----IPTPQASLSLH
            300       310       320             330           340  

             320       330       340       350       360        370
pF1KSD VIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSP-DTMLA
                 : . ..    :: : .:  .:   . : ::  .   :     :: : .  
NP_055 ----------GLNTSTYLHCEA-PAEPLPAQAASGTQ-DG-VHVQEPRPQAPSPLDLQQP
                      350        360        370        380         

              380          390       400         410       420     
pF1KSD SPQEEGEGPSSTTESSER---SEPGLLIPEMKDTSMERL--GQPLSKVIDQLNGQLD---
         .  :. ::::.  . :   .  ::   . .: .  .:  ..: :    .  .. :   
NP_055 VESTSGQQPSSTVSETAREVGQGNGLQKAQAHDGAGLKLVVSSPTSPKNKSWISEDDFYR
     390       400       410       420       430       440         

               430       440       450       460       470         
pF1KSD PST---WCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGG
       ::      : .. :  :.: :.::. :                                 
NP_055 PSREQPLESASDHPIASYR-GTPGSRPGLHRHFSQEPRKNCSLGALDQACVPSPGRRQAQ
     450       460        470       480       490       500        

>>XP_016880940 (OMIM: 611466,611497) PREDICTED: pleckstr  (1056 aa)
 initn: 247 init1: 199 opt: 240  Z-score: 182.7  bits: 45.4 E(85289): 0.0019
Smith-Waterman score: 270; 24.8% identity (49.3% similar) in 499 aa overlap (1-446:9-475)

                       10        20        30        40        50  
pF1KSD         MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHA
               ..:  .   : ...  ::: ::. ... .    .. ..:   . .:  :. .
XP_016 MLSVVENGLDPQAAIPVIKKKLVGSVKALQKQYVSLDT---VVTSEDGDANTMCSALEAV
               10        20        30           40        50       

                 60                        70        80        90  
pF1KSD LLYGLQD----LSSG----------------YWVLVVHFTRREAIKQIEVLQHVATNLGR
       ...::.       .:                .: :.   :... :...: :  : :..::
XP_016 FIHGLHAKHIRAEAGGKRKKSAHQKPLPQPVFWPLLKAVTHKHIISELEHLTFVNTDVGR
        60        70        80        90       100       110       

            100       110       120       130       140       150  
pF1KSD SRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFE
        :::: ::::.. .: ::.:. .. . ::.::  .::. . ..  ..:....::  . ::
XP_016 CRAWLRLALNDGLMECYLKLLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFE
       120       130       140       150       160       170       

            160          170       180       190       200         
pF1KSD LDLDAPYLD---LAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVT----STNL
       :.  .  :.   :.:   .   :   ::     : :. :..    .:..:..    : ..
XP_016 LSYKSAILNEWTLTPLALSGLCPLSELD-----PLSTSGAELQRKESLDSISHSSGSEDI
       180       190       200            210       220       230  

         210               220       230          240        250   
pF1KSD EWDDSA--------IAPSSEDYDFGDVFPAVPSVPSTD---WEDGDLT-DTVSGPRSTAS
       :   :.        .. :: . : ..      :. : .    :.:. . :    : :  :
XP_016 EVHHSGHKIRRNQKLTASSLSLDTASSSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDS
            240       250       260       270       280       290  

           260         270       280       290       300       310 
pF1KSD DLTSSKA--STRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELE
       :: ...:  : ::  .    :..  ...:      :..  ::: :    .  :.:   :.
XP_016 DLGTANAEDSDRSLQEVLLEFSKAQVNSV------PTNGLSQETE----IPTPQASLSLH
            300       310       320             330           340  

             320       330       340       350       360        370
pF1KSD VIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSP-DTMLA
                 : . ..    :: : .:  .:   . : ::  .   :     :: : .  
XP_016 ----------GLNTSTYLHCEA-PAEPLPAQAASGTQ-DG-VHVQEPRPQAPSPLDLQQP
                      350        360        370        380         

              380          390       400         410       420     
pF1KSD SPQEEGEGPSSTTESSER---SEPGLLIPEMKDTSMERL--GQPLSKVIDQLNGQLD---
         .  :. ::::.  . :   .  ::   . .: .  .:  ..: :    .  .. :   
XP_016 VESTSGQQPSSTVSETAREVGQGNGLQKAQAHDGAGLKLVVSSPTSPKNKSWISEDDFYR
     390       400       410       420       430       440         

               430       440       450       460       470         
pF1KSD PST---WCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGG
       ::      : .. :  :.: :.::. :                                 
XP_016 PSREQPLESASDHPIASYR-GTPGSRPGLHRHFSQEPRKNCSLGALDQACVPSPGRRQAQ
     450       460        470       480       490       500        

>>XP_011523825 (OMIM: 611466,611497) PREDICTED: pleckstr  (1056 aa)
 initn: 247 init1: 199 opt: 240  Z-score: 182.7  bits: 45.4 E(85289): 0.0019
Smith-Waterman score: 270; 24.8% identity (49.3% similar) in 499 aa overlap (1-446:9-475)

                       10        20        30        40        50  
pF1KSD         MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHA
               ..:  .   : ...  ::: ::. ... .    .. ..:   . .:  :. .
XP_011 MLSVVENGLDPQAAIPVIKKKLVGSVKALQKQYVSLDT---VVTSEDGDANTMCSALEAV
               10        20        30           40        50       

                 60                        70        80        90  
pF1KSD LLYGLQD----LSSG----------------YWVLVVHFTRREAIKQIEVLQHVATNLGR
       ...::.       .:                .: :.   :... :...: :  : :..::
XP_011 FIHGLHAKHIRAEAGGKRKKSAHQKPLPQPVFWPLLKAVTHKHIISELEHLTFVNTDVGR
        60        70        80        90       100       110       

            100       110       120       130       140       150  
pF1KSD SRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFE
        :::: ::::.. .: ::.:. .. . ::.::  .::. . ..  ..:....::  . ::
XP_011 CRAWLRLALNDGLMECYLKLLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFE
       120       130       140       150       160       170       

            160          170       180       190       200         
pF1KSD LDLDAPYLD---LAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVT----STNL
       :.  .  :.   :.:   .   :   ::     : :. :..    .:..:..    : ..
XP_011 LSYKSAILNEWTLTPLALSGLCPLSELD-----PLSTSGAELQRKESLDSISHSSGSEDI
       180       190       200            210       220       230  

         210               220       230          240        250   
pF1KSD EWDDSA--------IAPSSEDYDFGDVFPAVPSVPSTD---WEDGDLT-DTVSGPRSTAS
       :   :.        .. :: . : ..      :. : .    :.:. . :    : :  :
XP_011 EVHHSGHKIRRNQKLTASSLSLDTASSSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDS
            240       250       260       270       280       290  

           260         270       280       290       300       310 
pF1KSD DLTSSKA--STRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELE
       :: ...:  : ::  .    :..  ...:      :..  ::: :    .  :.:   :.
XP_011 DLGTANAEDSDRSLQEVLLEFSKAQVNSV------PTNGLSQETE----IPTPQASLSLH
            300       310       320             330           340  

             320       330       340       350       360        370
pF1KSD VIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSP-DTMLA
                 : . ..    :: : .:  .:   . : ::  .   :     :: : .  
XP_011 ----------GLNTSTYLHCEA-PAEPLPAQAASGTQ-DG-VHVQEPRPQAPSPLDLQQP
                      350        360        370        380         

              380          390       400         410       420     
pF1KSD SPQEEGEGPSSTTESSER---SEPGLLIPEMKDTSMERL--GQPLSKVIDQLNGQLD---
         .  :. ::::.  . :   .  ::   . .: .  .:  ..: :    .  .. :   
XP_011 VESTSGQQPSSTVSETAREVGQGNGLQKAQAHDGAGLKLVVSSPTSPKNKSWISEDDFYR
     390       400       410       420       430       440         

               430       440       450       460       470         
pF1KSD PST---WCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGG
       ::      : .. :  :.: :.::. :                                 
XP_011 PSREQPLESASDHPIASYR-GTPGSRPGLHRHFSQEPRKNCSLGALDQACVPSPGRRQAQ
     450       460        470       480       490       500        

>>XP_016880941 (OMIM: 611466,611497) PREDICTED: pleckstr  (967 aa)
 initn: 246 init1: 198 opt: 223  Z-score: 171.0  bits: 43.1 E(85289): 0.0087
Smith-Waterman score: 251; 26.8% identity (50.0% similar) in 406 aa overlap (74-446:10-386)

            50        60        70        80        90       100   
pF1KSD RLCEHLDHALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNE
                                     :. :...: :  : :..:: :::: ::::.
XP_016                      MDWTPRLPSRHIISELEHLTFVNTDVGRCRAWLRLALND
                                    10        20        30         

           110       120       130       140       150       160   
pF1KSD NSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLD--
       . .: ::.:. .. . ::.::  .::. . ..  ..:....::  . :::.  .  :.  
XP_016 GLMECYLKLLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFELSYKSAILNEW
      40        50        60        70        80        90         

              170       180       190       200           210      
pF1KSD -LAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVT----STNLEWDDSA-----
        :.:   .   :   ::     : :. :..    .:..:..    : ..:   :.     
XP_016 TLTPLALSGLCPLSELD-----PLSTSGAELQRKESLDSISHSSGSEDIEVHHSGHKIRR
     100       110            120       130       140       150    

                220       230          240        250       260    
pF1KSD ---IAPSSEDYDFGDVFPAVPSVPSTD---WEDGDLT-DTVSGPRSTASDLTSSKA--ST
          .. :: . : ..      :. : .    :.:. . :    : :  ::: ...:  : 
XP_016 NQKLTASSLSLDTASSSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDSDLGTANAEDSD
          160       170       180       190       200       210    

            270       280       290       300       310       320  
pF1KSD RSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELEVIRVTKKKKIG
       ::  .    :..  ...:      :..  ::: :    .  :.:   :.          :
XP_016 RSLQEVLLEFSKAQVNSV------PTNGLSQETE----IPTPQASLSLH----------G
          220       230             240           250              

            330       340       350       360        370       380 
pF1KSD KKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSP-DTMLASPQEEGEGPSS
        . ..    :: : .:  .:   . : ::  .   :     :: : .    .  :. :::
XP_016 LNTSTYLHCEA-PAEPLPAQAASGTQ-DG-VHVQEPRPQAPSPLDLQQPVESTSGQQPSS
          260        270        280        290       300       310 

                390       400         410       420             430
pF1KSD TTESSER---SEPGLLIPEMKDTSMERL--GQPLSKVIDQLNGQLD---PST---WCSRA
       :.  . :   .  ::   . .: .  .:  ..: :    .  .. :   ::      : .
XP_016 TVSETAREVGQGNGLQKAQAHDGAGLKLVVSSPTSPKNKSWISEDDFYRPSREQPLESAS
             320       330       340       350       360       370 

              440       450       460       470       480       490
pF1KSD EPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGGHHDPAGLGQP
       . :  :.: :.::. :                                            
XP_016 DHPIASYR-GTPGSRPGLHRHFSQEPRKNCSLGALDQACVPSPGRRQAQAAPSQGHKSFR
              380       390       400       410       420       430




1019 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 18:45:49 2016 done: Thu Nov  3 18:45:52 2016
 Total Scan time: 17.170 Total Display time:  0.300

Function used was FASTA [36.3.4 Apr, 2011]
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