Result of FASTA (omim) for pF1KB5053
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5053, 780 aa
  1>>>pF1KB5053 780 - 780 aa - 780 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.6739+/-0.000435; mu= 18.5914+/- 0.027
 mean_var=74.0253+/-15.048, 0's: 0 Z-trim(111.0): 68  B-trim: 632 in 1/52
 Lambda= 0.149068
 statistics sampled from 19424 (19463) to 19424 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.588), E-opt: 0.2 (0.228), width:  16
 Scan time:  9.170

The best scores are:                                      opt bits E(85289)
NP_001089 (OMIM: 100850,614559,616289) aconitate h ( 780) 5255 1140.2       0
XP_016884301 (OMIM: 100850,614559,616289) PREDICTE ( 747) 5047 1095.5       0
XP_005251533 (OMIM: 100880) PREDICTED: cytoplasmic ( 889)  352 85.8 8.9e-16
NP_002188 (OMIM: 100880) cytoplasmic aconitate hyd ( 889)  352 85.8 8.9e-16
NP_001265281 (OMIM: 100880) cytoplasmic aconitate  ( 889)  352 85.8 8.9e-16
XP_011516190 (OMIM: 100880) PREDICTED: cytoplasmic ( 889)  352 85.8 8.9e-16
NP_001307870 (OMIM: 147582) iron-responsive elemen ( 713)  325 79.9 4.1e-14
NP_001307871 (OMIM: 147582) iron-responsive elemen ( 906)  325 80.0   5e-14
NP_004127 (OMIM: 147582) iron-responsive element-b ( 963)  325 80.0 5.3e-14
NP_001307872 (OMIM: 147582) iron-responsive elemen ( 343)  170 46.4 0.00024


>>NP_001089 (OMIM: 100850,614559,616289) aconitate hydra  (780 aa)
 initn: 5255 init1: 5255 opt: 5255  Z-score: 6103.8  bits: 1140.2 E(85289):    0
Smith-Waterman score: 5255; 100.0% identity (100.0% similar) in 780 aa overlap (1-780:1-780)

               10        20        30        40        50        60
pF1KB5 MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 RPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 PSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILEN
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 YAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 WSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 HRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 VAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 EQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRN
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB5 DANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB5 QDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB5 GPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVI
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB5 GDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB5 VDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
              730       740       750       760       770       780

>>XP_016884301 (OMIM: 100850,614559,616289) PREDICTED: a  (747 aa)
 initn: 5047 init1: 5047 opt: 5047  Z-score: 5862.3  bits: 1095.5 E(85289):    0
Smith-Waterman score: 5047; 100.0% identity (100.0% similar) in 747 aa overlap (34-780:1-747)

            10        20        30        40        50        60   
pF1KB5 YSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLNRPL
                                     ::::::::::::::::::::::::::::::
XP_016                               MSHFEPNEYIHYDLLEKNINIVRKRLNRPL
                                             10        20        30

            70        80        90       100       110       120   
pF1KB5 TLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPST
               40        50        60        70        80        90

           130       140       150       160       170       180   
pF1KB5 IHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAY
              100       110       120       130       140       150

           190       200       210       220       230       240   
pF1KB5 PGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSS
              160       170       180       190       200       210

           250       260       270       280       290       300   
pF1KB5 PKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRM
              220       230       240       250       260       270

           310       320       330       340       350       360   
pF1KB5 KKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAE
              280       290       300       310       320       330

           370       380       390       400       410       420   
pF1KB5 VGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQI
              340       350       360       370       380       390

           430       440       450       460       470       480   
pF1KB5 RATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDAN
              400       410       420       430       440       450

           490       500       510       520       530       540   
pF1KB5 PETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDT
              460       470       480       490       500       510

           550       560       570       580       590       600   
pF1KB5 YQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPW
              520       530       540       550       560       570

           610       620       630       640       650       660   
pF1KB5 LKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDE
              580       590       600       610       620       630

           670       680       690       700       710       720   
pF1KB5 NYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDK
              640       650       660       670       680       690

           730       740       750       760       770       780
pF1KB5 LTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
              700       710       720       730       740       

>>XP_005251533 (OMIM: 100880) PREDICTED: cytoplasmic aco  (889 aa)
 initn: 689 init1: 303 opt: 352  Z-score: 404.3  bits: 85.8 E(85289): 8.9e-16
Smith-Waterman score: 737; 28.5% identity (54.4% similar) in 744 aa overlap (91-709:78-818)

               70        80        90       100       110          
pF1KB5 RPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQF--ISSGLSKV
                                     ..: :: .:: :.  :...:  . ....:.
XP_005 RNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKL
        50        60        70        80        90       100       

               120       130        140           150        160   
pF1KB5 A---------VPSTIHCDHLIEAQVGGEKD-LRRAKDI----NQEVYNFLATAG-AKYGV
       .          :. .  :: :... . . : :.. .:.    :.: ..::  .. : ...
XP_005 GGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNM
       110       120       130       140       150       160       

           170                 180       190       200       210   
pF1KB5 GFWKPGSGIIHQIILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADA
        .  ::::::::. ::          .: ::  : .::::::    ::: .  :::: .:
XP_005 RIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSL-VGTDSHTTMIDGLGILGWGVGGIEA
       170       180       190       200        210       220      

           220       230       240       250       260       270   
pF1KB5 VDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVD
         :: : :  .  :.::: .: :.     .  :..: ..  :   : .: .::. :::: 
XP_005 EAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVA
        230       240       250       260       270       280      

           280       290       300       310               320     
pF1KB5 SISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRED--------IANLADEFKDH
       ..: .  ::: ::  : :::.. :: ..    :: .:::..          . .  :.: 
XP_005 QLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDF
        290       300       310       320       330       340      

         330       340       350       360            370          
pF1KB5 LVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGK-----VAEKEGW------P
         :.    . :..:..:. . :  .::  :.    :... :     .. :.:.      :
XP_005 NDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAP
        350       360       370       380       390       400      

                              380       390        400       410   
pF1KB5 ----------LD----------IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKS-
                  :          . .. : ::::.:  ..  .:.. ::.:.  ::.    
XP_005 EHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPY
        410       420       430       440       450       460      

             420       430       440       450             460     
pF1KB5 -QFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDR------KDIKKGEK
        . ...:::  .   ....:    : .::  :.. .:  :::.         . : .:. 
XP_005 IKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDL
        470       480       490       500       510       520      

          470       480        490       500       510        520  
pF1KB5 NTI-VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDYL-TGTDGKKF
        .. : : :::: ::  ..:.:.: ...:: .: : :::::.... : . : ... :.. 
XP_005 VAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQV
        530       540         550       560       570       580    

              530          540         550       560               
pF1KB5 RLEA--PDADELPKGEFD---PG--QDTYQHPPKDSSGQHVDVSPT-------SQRLQLL
        :.   :  ::.   : .   ::  ...::.    . . .. ..:.       :.   . 
XP_005 FLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIK
          590       600       610       620       630       640    

      570              580       590       600                     
pF1KB5 EP-------FDKWDGKDLEDLQILIKVKGKCTTDHISAAG------PWLKF---RG----
        :       .:    :.. :  .:...  . :::::: ::      :  ..   ::    
XP_005 SPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPR
          650       660       670       680       690       700    

      610       620                    630       640       650     
pF1KB5 HLDNISNNLLIGAI-------NIE------NGKANSVRNAVTQEFGPVPDTARYYKKHGI
       .... ..     :.       ::.      : .: .. .  . :.  : :.:. :.. :.
XP_005 EFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGL
          710       720       730       740       750       760    

         660       670       680       690       700       710     
pF1KB5 RWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADY
         .:.. ..:: ::::. ::  :  :: .:....:. :::..::  .:..:: .      
XP_005 PLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENA
          770       780       790       800       810       820    

         720       730       740       750       760       770     
pF1KB5 NKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRM
                                                                   
XP_005 DALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMI
          830       840       850       860       870       880    

>>NP_002188 (OMIM: 100880) cytoplasmic aconitate hydrata  (889 aa)
 initn: 689 init1: 303 opt: 352  Z-score: 404.3  bits: 85.8 E(85289): 8.9e-16
Smith-Waterman score: 737; 28.5% identity (54.4% similar) in 744 aa overlap (91-709:78-818)

               70        80        90       100       110          
pF1KB5 RPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQF--ISSGLSKV
                                     ..: :: .:: :.  :...:  . ....:.
NP_002 RNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKL
        50        60        70        80        90       100       

               120       130        140           150        160   
pF1KB5 A---------VPSTIHCDHLIEAQVGGEKD-LRRAKDI----NQEVYNFLATAG-AKYGV
       .          :. .  :: :... . . : :.. .:.    :.: ..::  .. : ...
NP_002 GGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNM
       110       120       130       140       150       160       

           170                 180       190       200       210   
pF1KB5 GFWKPGSGIIHQIILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADA
        .  ::::::::. ::          .: ::  : .::::::    ::: .  :::: .:
NP_002 RIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSL-VGTDSHTTMIDGLGILGWGVGGIEA
       170       180       190       200        210       220      

           220       230       240       250       260       270   
pF1KB5 VDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVD
         :: : :  .  :.::: .: :.     .  :..: ..  :   : .: .::. :::: 
NP_002 EAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVA
        230       240       250       260       270       280      

           280       290       300       310               320     
pF1KB5 SISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRED--------IANLADEFKDH
       ..: .  ::: ::  : :::.. :: ..    :: .:::..          . .  :.: 
NP_002 QLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDF
        290       300       310       320       330       340      

         330       340       350       360            370          
pF1KB5 LVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGK-----VAEKEGW------P
         :.    . :..:..:. . :  .::  :.    :... :     .. :.:.      :
NP_002 NDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAP
        350       360       370       380       390       400      

                              380       390        400       410   
pF1KB5 ----------LD----------IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKS-
                  :          . .. : ::::.:  ..  .:.. ::.:.  ::.    
NP_002 EHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPY
        410       420       430       440       450       460      

             420       430       440       450             460     
pF1KB5 -QFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDR------KDIKKGEK
        . ...:::  .   ....:    : .::  :.. .:  :::.         . : .:. 
NP_002 IKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDL
        470       480       490       500       510       520      

          470       480        490       500       510        520  
pF1KB5 NTI-VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDYL-TGTDGKKF
        .. : : :::: ::  ..:.:.: ...:: .: : :::::.... : . : ... :.. 
NP_002 VAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQV
        530       540         550       560       570       580    

              530          540         550       560               
pF1KB5 RLEA--PDADELPKGEFD---PG--QDTYQHPPKDSSGQHVDVSPT-------SQRLQLL
        :.   :  ::.   : .   ::  ...::.    . . .. ..:.       :.   . 
NP_002 FLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIK
          590       600       610       620       630       640    

      570              580       590       600                     
pF1KB5 EP-------FDKWDGKDLEDLQILIKVKGKCTTDHISAAG------PWLKF---RG----
        :       .:    :.. :  .:...  . :::::: ::      :  ..   ::    
NP_002 SPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPR
          650       660       670       680       690       700    

      610       620                    630       640       650     
pF1KB5 HLDNISNNLLIGAI-------NIE------NGKANSVRNAVTQEFGPVPDTARYYKKHGI
       .... ..     :.       ::.      : .: .. .  . :.  : :.:. :.. :.
NP_002 EFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGL
          710       720       730       740       750       760    

         660       670       680       690       700       710     
pF1KB5 RWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADY
         .:.. ..:: ::::. ::  :  :: .:....:. :::..::  .:..:: .      
NP_002 PLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENA
          770       780       790       800       810       820    

         720       730       740       750       760       770     
pF1KB5 NKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRM
                                                                   
NP_002 DALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMI
          830       840       850       860       870       880    

>>NP_001265281 (OMIM: 100880) cytoplasmic aconitate hydr  (889 aa)
 initn: 689 init1: 303 opt: 352  Z-score: 404.3  bits: 85.8 E(85289): 8.9e-16
Smith-Waterman score: 737; 28.5% identity (54.4% similar) in 744 aa overlap (91-709:78-818)

               70        80        90       100       110          
pF1KB5 RPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQF--ISSGLSKV
                                     ..: :: .:: :.  :...:  . ....:.
NP_001 RNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKL
        50        60        70        80        90       100       

               120       130        140           150        160   
pF1KB5 A---------VPSTIHCDHLIEAQVGGEKD-LRRAKDI----NQEVYNFLATAG-AKYGV
       .          :. .  :: :... . . : :.. .:.    :.: ..::  .. : ...
NP_001 GGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNM
       110       120       130       140       150       160       

           170                 180       190       200       210   
pF1KB5 GFWKPGSGIIHQIILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADA
        .  ::::::::. ::          .: ::  : .::::::    ::: .  :::: .:
NP_001 RIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSL-VGTDSHTTMIDGLGILGWGVGGIEA
       170       180       190       200        210       220      

           220       230       240       250       260       270   
pF1KB5 VDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVD
         :: : :  .  :.::: .: :.     .  :..: ..  :   : .: .::. :::: 
NP_001 EAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVA
        230       240       250       260       270       280      

           280       290       300       310               320     
pF1KB5 SISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRED--------IANLADEFKDH
       ..: .  ::: ::  : :::.. :: ..    :: .:::..          . .  :.: 
NP_001 QLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDF
        290       300       310       320       330       340      

         330       340       350       360            370          
pF1KB5 LVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGK-----VAEKEGW------P
         :.    . :..:..:. . :  .::  :.    :... :     .. :.:.      :
NP_001 NDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAP
        350       360       370       380       390       400      

                              380       390        400       410   
pF1KB5 ----------LD----------IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKS-
                  :          . .. : ::::.:  ..  .:.. ::.:.  ::.    
NP_001 EHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPY
        410       420       430       440       450       460      

             420       430       440       450             460     
pF1KB5 -QFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDR------KDIKKGEK
        . ...:::  .   ....:    : .::  :.. .:  :::.         . : .:. 
NP_001 IKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDL
        470       480       490       500       510       520      

          470       480        490       500       510        520  
pF1KB5 NTI-VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDYL-TGTDGKKF
        .. : : :::: ::  ..:.:.: ...:: .: : :::::.... : . : ... :.. 
NP_001 VAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQV
        530       540         550       560       570       580    

              530          540         550       560               
pF1KB5 RLEA--PDADELPKGEFD---PG--QDTYQHPPKDSSGQHVDVSPT-------SQRLQLL
        :.   :  ::.   : .   ::  ...::.    . . .. ..:.       :.   . 
NP_001 FLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIK
          590       600       610       620       630       640    

      570              580       590       600                     
pF1KB5 EP-------FDKWDGKDLEDLQILIKVKGKCTTDHISAAG------PWLKF---RG----
        :       .:    :.. :  .:...  . :::::: ::      :  ..   ::    
NP_001 SPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPR
          650       660       670       680       690       700    

      610       620                    630       640       650     
pF1KB5 HLDNISNNLLIGAI-------NIE------NGKANSVRNAVTQEFGPVPDTARYYKKHGI
       .... ..     :.       ::.      : .: .. .  . :.  : :.:. :.. :.
NP_001 EFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGL
          710       720       730       740       750       760    

         660       670       680       690       700       710     
pF1KB5 RWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADY
         .:.. ..:: ::::. ::  :  :: .:....:. :::..::  .:..:: .      
NP_001 PLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENA
          770       780       790       800       810       820    

         720       730       740       750       760       770     
pF1KB5 NKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRM
                                                                   
NP_001 DALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMI
          830       840       850       860       870       880    

>>XP_011516190 (OMIM: 100880) PREDICTED: cytoplasmic aco  (889 aa)
 initn: 689 init1: 303 opt: 352  Z-score: 404.3  bits: 85.8 E(85289): 8.9e-16
Smith-Waterman score: 737; 28.5% identity (54.4% similar) in 744 aa overlap (91-709:78-818)

               70        80        90       100       110          
pF1KB5 RPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQF--ISSGLSKV
                                     ..: :: .:: :.  :...:  . ....:.
XP_011 RNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKL
        50        60        70        80        90       100       

               120       130        140           150        160   
pF1KB5 A---------VPSTIHCDHLIEAQVGGEKD-LRRAKDI----NQEVYNFLATAG-AKYGV
       .          :. .  :: :... . . : :.. .:.    :.: ..::  .. : ...
XP_011 GGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNM
       110       120       130       140       150       160       

           170                 180       190       200       210   
pF1KB5 GFWKPGSGIIHQIILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADA
        .  ::::::::. ::          .: ::  : .::::::    ::: .  :::: .:
XP_011 RIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSL-VGTDSHTTMIDGLGILGWGVGGIEA
       170       180       190       200        210       220      

           220       230       240       250       260       270   
pF1KB5 VDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVD
         :: : :  .  :.::: .: :.     .  :..: ..  :   : .: .::. :::: 
XP_011 EAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVA
        230       240       250       260       270       280      

           280       290       300       310               320     
pF1KB5 SISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRED--------IANLADEFKDH
       ..: .  ::: ::  : :::.. :: ..    :: .:::..          . .  :.: 
XP_011 QLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDF
        290       300       310       320       330       340      

         330       340       350       360            370          
pF1KB5 LVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGK-----VAEKEGW------P
         :.    . :..:..:. . :  .::  :.    :... :     .. :.:.      :
XP_011 NDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAP
        350       360       370       380       390       400      

                              380       390        400       410   
pF1KB5 ----------LD----------IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKS-
                  :          . .. : ::::.:  ..  .:.. ::.:.  ::.    
XP_011 EHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPY
        410       420       430       440       450       460      

             420       430       440       450             460     
pF1KB5 -QFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDR------KDIKKGEK
        . ...:::  .   ....:    : .::  :.. .:  :::.         . : .:. 
XP_011 IKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDL
        470       480       490       500       510       520      

          470       480        490       500       510        520  
pF1KB5 NTI-VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDYL-TGTDGKKF
        .. : : :::: ::  ..:.:.: ...:: .: : :::::.... : . : ... :.. 
XP_011 VAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQV
        530       540         550       560       570       580    

              530          540         550       560               
pF1KB5 RLEA--PDADELPKGEFD---PG--QDTYQHPPKDSSGQHVDVSPT-------SQRLQLL
        :.   :  ::.   : .   ::  ...::.    . . .. ..:.       :.   . 
XP_011 FLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIK
          590       600       610       620       630       640    

      570              580       590       600                     
pF1KB5 EP-------FDKWDGKDLEDLQILIKVKGKCTTDHISAAG------PWLKF---RG----
        :       .:    :.. :  .:...  . :::::: ::      :  ..   ::    
XP_011 SPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPR
          650       660       670       680       690       700    

      610       620                    630       640       650     
pF1KB5 HLDNISNNLLIGAI-------NIE------NGKANSVRNAVTQEFGPVPDTARYYKKHGI
       .... ..     :.       ::.      : .: .. .  . :.  : :.:. :.. :.
XP_011 EFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGL
          710       720       730       740       750       760    

         660       670       680       690       700       710     
pF1KB5 RWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADY
         .:.. ..:: ::::. ::  :  :: .:....:. :::..::  .:..:: .      
XP_011 PLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENA
          770       780       790       800       810       820    

         720       730       740       750       760       770     
pF1KB5 NKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRM
                                                                   
XP_011 DALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMI
          830       840       850       860       870       880    

>>NP_001307870 (OMIM: 147582) iron-responsive element-bi  (713 aa)
 initn: 495 init1: 283 opt: 325  Z-score: 374.3  bits: 79.9 E(85289): 4.1e-14
Smith-Waterman score: 571; 28.2% identity (52.4% similar) in 639 aa overlap (173-709:10-643)

            150       160       170         180       190       200
pF1KB5 AKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILE--NYAYPGVLLIGTDSHTPNGGG
                                     . ....:  .  .:  . .:::::    .:
NP_001                      MAHQINLEYLSRVVFEEKDLLFPDSV-VGTDSHITMVNG
                                    10        20         30        

              210       220       230       240       250       260
pF1KB5 LGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGG
       :: .  :::: ..  :: :.:  :  :.:.: .:::: . . .  ::.: ..  :   : 
NP_001 LGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGV
       40        50        60        70        80        90        

              270       280       290       300       310          
pF1KB5 TGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTG--------R
       .: .::. : ::...: .  .:: ::  : ::  : :: ..   :.: .::         
NP_001 AGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESM
      100       110       120       130       140       150        

            320       330       340       350                  360 
pF1KB5 EDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTP-----------DLAHPV
       :   . .  :..    .   .:.:.:.:::. . : ..::  :           :.   .
NP_001 ETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACL
      160       170       180       190       200       210        

                   370                     380       390        400
pF1KB5 AE-VG-----KVAEK---------EG--WPLD---IRVGLIGSCTNSSYEDMGRSAAV-A
        : ::      .:::         ::  . :.   . .. . ::::.   ..  .:.. :
NP_001 NEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLA
      220       230       240       250       260       270        

              410         420       430       440       450        
pF1KB5 KQALAHGLKCKSQF--TITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQW-DR
       :.:.  ::. :  .  ...::: ..   .  .:    :  ::  ... .:. :.:.    
NP_001 KKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPL
      280       290       300       310       320       330        

            460        470       480       490       500       510 
pF1KB5 KD-----IKKGEKNTI-VTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPET
       .:     .:.:.  :  . : :.:: ::   .     ...:: .:.: :::::.... .:
NP_001 SDAVLNAVKQGDLVTCGILSGNKNFEGRL-CDCVRANYLASPPLVVAYAIAGTVNIDFQT
      340       350       360        370       380       390       

               520         530               540               550 
pF1KB5 DYLTGTD--GKKFRLEA--PDADELPKGE--------FDPGQDTYQHPPK--------DS
       . : :::  ::.. :.   :. .:. . :        :   .:  .   :        ::
NP_001 EPL-GTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDS
       400        410       420       430       440       450      

             560       570            580       590       600      
pF1KB5 SGQHVDVSPTSQRLQLLEPFDKWDGKDL-----EDLQILIKVKGKCTTDHISAAGPWLKF
            :.. :  :   .  :::   . .     :. ..:. .  . :::::: ::   . 
NP_001 VLFPWDLKSTYIRCPSF--FDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARN
        460       470         480       490       500       510    

        610           620        630         640                   
pF1KB5 RGHLDNISNNLL----IGAINIENGK-ANSVRN--AVTQEFG-----PVPDT--------
        .    ..:  :    ... . . :. :  .:.  :  . :.     :.: :        
NP_001 SAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQT
          520       530       540       550       560       570    

              650       660       670       680       690       700
pF1KB5 ------ARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLK
             :. :.:.::  .... ..:: :.::. ::  :  :: .:....:. .::. .: 
NP_001 LDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLI
          580       590       600       610       620       630    

              710       720       730       740       750       760
pF1KB5 KQGLLPLTFADPADYNKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNE
         :. :: :                                                   
NP_001 GIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDV
          640       650       660       670       680       690    

>>NP_001307871 (OMIM: 147582) iron-responsive element-bi  (906 aa)
 initn: 571 init1: 283 opt: 325  Z-score: 372.7  bits: 80.0 E(85289): 5e-14
Smith-Waterman score: 600; 28.3% identity (52.1% similar) in 674 aa overlap (147-709:168-836)

        120       130       140       150       160        170     
pF1KB5 KVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKY-GVGFWKPGSGIIHQ
                                     :.:  .:.  ..  . .:.   ::.:. ::
NP_001 ENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQ
       140       150       160       170       180       190       

                   180       190       200       210       220     
pF1KB5 IILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELK
       : ::          .  .:  . .:::::    .::: .  :::: ..  :: :.:  : 
NP_001 INLEYLSRVVFEEKDLLFPDSV-VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLT
       200       210        220       230       240       250      

         230       240       250       260       270       280     
pF1KB5 CPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICN
        :.:.: .:::: . . .  ::.: ..  :   : .: .::. : ::...: .  .:: :
NP_001 LPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIAN
        260       270       280       290       300       310      

         290       300       310               320       330       
pF1KB5 MGAEIGATTSVFPYNHRMKKYLSKTG--------REDIANLADEFKDHLVPDPGCHYDQL
       :  : ::  : :: ..   :.: .::         :   . .  :..    .   .:.:.
NP_001 MCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQV
        320       330       340       350       360       370      

       340       350                  360             370          
pF1KB5 IEINLSELKPHINGPFTP-----------DLAHPVAE-VG-----KVAEK---------E
       :.:::. . : ..::  :           :.   . : ::      .:::         :
NP_001 IQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYE
        380       390       400       410       420       430      

                  380       390        400       410         420   
pF1KB5 G--WPLD---IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKSQF--TITPGSEQI
       :  . :.   . .. . ::::.   ..  .:.. ::.:.  ::. :  .  ...::: ..
NP_001 GSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMV
        440       450       460       470       480       490      

           430       440       450             460        470      
pF1KB5 RATIERDGYAQILRDLGGIVLANACGPCIGQW-DRKD-----IKKGEKNTI-VTSYNRNF
          .  .:    :  ::  ... .:. :.:.    .:     .:.:.  :  . : :.::
NP_001 THYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNF
        500       510       520       530       540       550      

        480       490       500       510         520         530  
pF1KB5 TGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTD--GKKFRLEA--PDADEL
        ::   .     ...:: .:.: :::::.... .:. : :::  ::.. :.   :. .:.
NP_001 EGRL-CDCVRANYLASPPLVVAYAIAGTVNIDFQTEPL-GTDPTGKNIYLHDIWPSREEV
        560        570       580       590        600       610    

                    540               550       560       570      
pF1KB5 PKGE--------FDPGQDTYQHPPK--------DSSGQHVDVSPTSQRLQLLEPFDKWDG
        . :        :   .:  .   :        ::     :.. :  :   .  :::   
NP_001 HRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSF--FDKLTK
          620       630       640       650       660         670  

             580       590       600       610           620       
pF1KB5 KDL-----EDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLL----IGAINIENG
       . .     :. ..:. .  . :::::: ::   .  .    ..:  :    ... . . :
NP_001 EPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRG
            680       690       700       710       720       730  

        630         640                          650       660     
pF1KB5 K-ANSVRN--AVTQEFG-----PVPDT--------------ARYYKKHGIRWVVIGDENY
       . :  .:.  :  . :.     :.: :              :. :.:.::  .... ..:
NP_001 NDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKY
            740       750       760       770       780       790  

         670       680       690       700       710       720     
pF1KB5 GEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLT
       : :.::. ::  :  :: .:....:. .::. .:   :. :: :                
NP_001 GSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRET
            800       810       820       830       840       850  

         730       740       750       760       770       780
pF1KB5 IQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
                                                              
NP_001 FSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKFS 
            860       870       880       890       900       

>>NP_004127 (OMIM: 147582) iron-responsive element-bindi  (963 aa)
 initn: 571 init1: 283 opt: 325  Z-score: 372.3  bits: 80.0 E(85289): 5.3e-14
Smith-Waterman score: 600; 28.3% identity (52.1% similar) in 674 aa overlap (147-709:225-893)

        120       130       140       150       160        170     
pF1KB5 KVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKY-GVGFWKPGSGIIHQ
                                     :.:  .:.  ..  . .:.   ::.:. ::
NP_004 ENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQ
          200       210       220       230       240       250    

                   180       190       200       210       220     
pF1KB5 IILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELK
       : ::          .  .:  . .:::::    .::: .  :::: ..  :: :.:  : 
NP_004 INLEYLSRVVFEEKDLLFPDSV-VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLT
          260       270        280       290       300       310   

         230       240       250       260       270       280     
pF1KB5 CPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICN
        :.:.: .:::: . . .  ::.: ..  :   : .: .::. : ::...: .  .:: :
NP_004 LPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIAN
           320       330       340       350       360       370   

         290       300       310               320       330       
pF1KB5 MGAEIGATTSVFPYNHRMKKYLSKTG--------REDIANLADEFKDHLVPDPGCHYDQL
       :  : ::  : :: ..   :.: .::         :   . .  :..    .   .:.:.
NP_004 MCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQV
           380       390       400       410       420       430   

       340       350                  360             370          
pF1KB5 IEINLSELKPHINGPFTP-----------DLAHPVAE-VG-----KVAEK---------E
       :.:::. . : ..::  :           :.   . : ::      .:::         :
NP_004 IQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYE
           440       450       460       470       480       490   

                  380       390        400       410         420   
pF1KB5 G--WPLD---IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKSQF--TITPGSEQI
       :  . :.   . .. . ::::.   ..  .:.. ::.:.  ::. :  .  ...::: ..
NP_004 GSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMV
           500       510       520       530       540       550   

           430       440       450             460        470      
pF1KB5 RATIERDGYAQILRDLGGIVLANACGPCIGQW-DRKD-----IKKGEKNTI-VTSYNRNF
          .  .:    :  ::  ... .:. :.:.    .:     .:.:.  :  . : :.::
NP_004 THYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNF
           560       570       580       590       600       610   

        480       490       500       510         520         530  
pF1KB5 TGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTD--GKKFRLEA--PDADEL
        ::   .     ...:: .:.: :::::.... .:. : :::  ::.. :.   :. .:.
NP_004 EGRL-CDCVRANYLASPPLVVAYAIAGTVNIDFQTEPL-GTDPTGKNIYLHDIWPSREEV
            620       630       640       650        660       670 

                    540               550       560       570      
pF1KB5 PKGE--------FDPGQDTYQHPPK--------DSSGQHVDVSPTSQRLQLLEPFDKWDG
        . :        :   .:  .   :        ::     :.. :  :   .  :::   
NP_004 HRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSF--FDKLTK
             680       690       700       710       720           

             580       590       600       610           620       
pF1KB5 KDL-----EDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLL----IGAINIENG
       . .     :. ..:. .  . :::::: ::   .  .    ..:  :    ... . . :
NP_004 EPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRG
     730       740       750       760       770       780         

        630         640                          650       660     
pF1KB5 K-ANSVRN--AVTQEFG-----PVPDT--------------ARYYKKHGIRWVVIGDENY
       . :  .:.  :  . :.     :.: :              :. :.:.::  .... ..:
NP_004 NDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKY
     790       800       810       820       830       840         

         670       680       690       700       710       720     
pF1KB5 GEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLT
       : :.::. ::  :  :: .:....:. .::. .:   :. :: :                
NP_004 GSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRET
     850       860       870       880       890       900         

         730       740       750       760       770       780
pF1KB5 IQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
                                                              
NP_004 FSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKFS 
     910       920       930       940       950       960    

>>NP_001307872 (OMIM: 147582) iron-responsive element-bi  (343 aa)
 initn: 240 init1: 164 opt: 170  Z-score: 199.0  bits: 46.4 E(85289): 0.00024
Smith-Waterman score: 199; 33.6% identity (58.0% similar) in 119 aa overlap (147-254:225-342)

        120       130       140       150       160        170     
pF1KB5 KVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKY-GVGFWKPGSGIIHQ
                                     :.:  .:.  ..  . .:.   ::.:. ::
NP_001 ENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQ
          200       210       220       230       240       250    

                   180       190       200       210       220     
pF1KB5 IILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELK
       : ::          .  .:  . .:::::    .::: .  :::: ..  :: :.:  : 
NP_001 INLEYLSRVVFEEKDLLFPDSV-VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLT
          260       270        280       290       300       310   

         230       240       250       260       270       280     
pF1KB5 CPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICN
        :.:.: .:::: . . .  ::.: .. .                               
NP_001 LPEVVGCELTGSSNPFVTSIDVVLGITKVS                              
           320       330       340                                 




780 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 15:50:10 2016 done: Thu Nov  3 15:50:12 2016
 Total Scan time:  9.170 Total Display time:  0.190

Function used was FASTA [36.3.4 Apr, 2011]
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