Result of FASTA (ccds) for pF1KB5026
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5026, 448 aa
  1>>>pF1KB5026 448 - 448 aa - 448 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.6708+/-0.00136; mu= 5.6779+/- 0.078
 mean_var=229.7659+/-52.864, 0's: 0 Z-trim(106.8): 657  B-trim: 365 in 2/46
 Lambda= 0.084612
 statistics sampled from 8436 (9211) to 8436 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.651), E-opt: 0.2 (0.283), width:  16
 Scan time:  3.090

The best scores are:                                      opt bits E(32554)
CCDS10224.1 MAP2K5 gene_id:5607|Hs108|chr15        ( 448) 3000 380.1 2.5e-105
CCDS55970.1 MAP2K5 gene_id:5607|Hs108|chr15        ( 412) 2691 342.3 5.4e-94
CCDS42051.1 MAP2K5 gene_id:5607|Hs108|chr15        ( 438) 2293 293.8 2.4e-79
CCDS10216.1 MAP2K1 gene_id:5604|Hs108|chr15        ( 393)  808 112.4 8.2e-25
CCDS11686.1 MAP2K6 gene_id:5608|Hs108|chr17        ( 334)  783 109.3 6.1e-24
CCDS12120.1 MAP2K2 gene_id:5605|Hs108|chr19        ( 400)  781 109.1 8.2e-24
CCDS82194.1 MAP2K6 gene_id:5608|Hs108|chr17        ( 278)  764 106.9 2.7e-23
CCDS11218.1 MAP2K3 gene_id:5606|Hs108|chr17        ( 318)  638 91.6 1.3e-18
CCDS11217.1 MAP2K3 gene_id:5606|Hs108|chr17        ( 347)  638 91.6 1.3e-18
CCDS42491.1 MAP2K7 gene_id:5609|Hs108|chr19        ( 419)  618 89.3 8.2e-18
CCDS74277.1 MAP2K7 gene_id:5609|Hs108|chr19        ( 435)  618 89.3 8.4e-18
CCDS2549.1 STK25 gene_id:10494|Hs108|chr2          ( 426)  575 84.0 3.2e-16
CCDS14631.1 STK26 gene_id:51765|Hs108|chrX         ( 416)  573 83.8 3.7e-16
CCDS32001.1 STK24 gene_id:8428|Hs108|chr13         ( 431)  568 83.2 5.8e-16
CCDS9488.1 STK24 gene_id:8428|Hs108|chr13          ( 443)  568 83.2 5.9e-16
CCDS59108.1 STK3 gene_id:6788|Hs108|chr8           ( 519)  566 83.0 7.7e-16
CCDS74278.1 MAP2K7 gene_id:5609|Hs108|chr19        ( 426)  560 82.2 1.1e-15
CCDS47900.1 STK3 gene_id:6788|Hs108|chr8           ( 491)  560 82.3 1.2e-15
CCDS13341.1 STK4 gene_id:6789|Hs108|chr20          ( 487)  558 82.0 1.5e-15
CCDS11162.1 MAP2K4 gene_id:6416|Hs108|chr17        ( 399)  553 81.3 1.9e-15
CCDS62095.1 MAP2K4 gene_id:6416|Hs108|chr17        ( 410)  553 81.3   2e-15
CCDS58707.1 MAP4K3 gene_id:8491|Hs108|chr2         ( 873)  504 75.7   2e-13
CCDS1803.1 MAP4K3 gene_id:8491|Hs108|chr2          ( 894)  504 75.7 2.1e-13
CCDS8250.1 PAK1 gene_id:5058|Hs108|chr11           ( 545)  490 73.8 4.9e-13
CCDS81582.1 MAP4K2 gene_id:5871|Hs108|chr11        ( 812)  484 73.2 1.1e-12
CCDS8082.1 MAP4K2 gene_id:5871|Hs108|chr11         ( 820)  484 73.2 1.1e-12
CCDS34290.1 STK10 gene_id:6793|Hs108|chr5          ( 968)  485 73.5 1.1e-12
CCDS44687.1 PAK1 gene_id:5058|Hs108|chr11          ( 553)  473 71.7 2.1e-12
CCDS3321.1 PAK2 gene_id:5062|Hs108|chr3            ( 524)  465 70.7   4e-12
CCDS13107.1 PAK5 gene_id:57144|Hs108|chr20         ( 719)  462 70.5 6.3e-12
CCDS14554.1 PAK3 gene_id:5063|Hs108|chrX           ( 544)  458 69.9 7.4e-12
CCDS48153.1 PAK3 gene_id:5063|Hs108|chrX           ( 559)  458 69.9 7.5e-12
CCDS48152.1 PAK3 gene_id:5063|Hs108|chrX           ( 565)  458 69.9 7.6e-12
CCDS48151.1 PAK3 gene_id:5063|Hs108|chrX           ( 580)  458 69.9 7.7e-12
CCDS42564.1 MAP4K1 gene_id:11184|Hs108|chr19       ( 821)  457 70.0   1e-11
CCDS59385.1 MAP4K1 gene_id:11184|Hs108|chr19       ( 833)  457 70.0 1.1e-11
CCDS48168.1 STK26 gene_id:51765|Hs108|chrX         ( 339)  438 67.2 2.9e-11
CCDS63200.1 STK25 gene_id:10494|Hs108|chr2         ( 349)  438 67.2   3e-11
CCDS76334.1 SLK gene_id:9748|Hs108|chr10           (1204)  445 68.7 3.7e-11
CCDS63199.1 STK25 gene_id:10494|Hs108|chr2         ( 332)  435 66.8 3.7e-11
CCDS7553.1 SLK gene_id:9748|Hs108|chr10            (1235)  445 68.7 3.8e-11
CCDS56024.1 TAOK1 gene_id:57551|Hs108|chr17        ( 853)  442 68.1 3.8e-11
CCDS32601.1 TAOK1 gene_id:57551|Hs108|chr17        (1001)  442 68.2 4.2e-11
CCDS9188.1 TAOK3 gene_id:51347|Hs108|chr12         ( 898)  438 67.7 5.5e-11
CCDS10662.1 TAOK2 gene_id:9344|Hs108|chr16         (1049)  434 67.3 8.6e-11
CCDS58448.1 TAOK2 gene_id:9344|Hs108|chr16         (1122)  434 67.3   9e-11
CCDS10663.1 TAOK2 gene_id:9344|Hs108|chr16         (1235)  434 67.4 9.6e-11


>>CCDS10224.1 MAP2K5 gene_id:5607|Hs108|chr15             (448 aa)
 initn: 3000 init1: 3000 opt: 3000  Z-score: 2004.4  bits: 380.1 E(32554): 2.5e-105
Smith-Waterman score: 3000; 100.0% identity (100.0% similar) in 448 aa overlap (1-448:1-448)

               10        20        30        40        50        60
pF1KB5 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
              370       380       390       400       410       420

              430       440        
pF1KB5 QFNDGNAAVVSMWVCRALEERRSQQGPP
       ::::::::::::::::::::::::::::
CCDS10 QFNDGNAAVVSMWVCRALEERRSQQGPP
              430       440        

>>CCDS55970.1 MAP2K5 gene_id:5607|Hs108|chr15             (412 aa)
 initn: 2691 init1: 2691 opt: 2691  Z-score: 1800.9  bits: 342.3 E(32554): 5.4e-94
Smith-Waterman score: 2691; 100.0% identity (100.0% similar) in 403 aa overlap (46-448:10-412)

          20        30        40        50        60        70     
pF1KB5 VLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSD
                                     ::::::::::::::::::::::::::::::
CCDS55                      MMEGHFPQSDVIGQVLPEATTTAFEYEDEDGDRITVRSD
                                    10        20        30         

          80        90       100       110       120       130     
pF1KB5 EEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 EEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPA
      40        50        60        70        80        90         

         140       150       160       170       180       190     
pF1KB5 VSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 VSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVK
     100       110       120       130       140       150         

         200       210       220       230       240       250     
pF1KB5 VILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 VILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM
     160       170       180       190       200       210         

         260       270       280       290       300       310     
pF1KB5 PEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 PEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKT
     220       230       240       250       260       270         

         320       330       340       350       360       370     
pF1KB5 YVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 YVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCI
     280       290       300       310       320       330         

         380       390       400       410       420       430     
pF1KB5 VDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 VDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVC
     340       350       360       370       380       390         

         440        
pF1KB5 RALEERRSQQGPP
       :::::::::::::
CCDS55 RALEERRSQQGPP
     400       410  

>>CCDS42051.1 MAP2K5 gene_id:5607|Hs108|chr15             (438 aa)
 initn: 2293 init1: 2293 opt: 2293  Z-score: 1538.0  bits: 293.8 E(32554): 2.4e-79
Smith-Waterman score: 2897; 97.8% identity (97.8% similar) in 448 aa overlap (1-448:1-438)

               10        20        30        40        50        60
pF1KB5 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::          ::
CCDS42 DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFME----------IQ
              310       320       330       340                 350

              370       380       390       400       410       420
pF1KB5 KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
              360       370       380       390       400       410

              430       440        
pF1KB5 QFNDGNAAVVSMWVCRALEERRSQQGPP
       ::::::::::::::::::::::::::::
CCDS42 QFNDGNAAVVSMWVCRALEERRSQQGPP
              420       430        

>>CCDS10216.1 MAP2K1 gene_id:5604|Hs108|chr15             (393 aa)
 initn: 917 init1: 400 opt: 808  Z-score: 558.9  bits: 112.4 E(32554): 8.2e-25
Smith-Waterman score: 885; 42.6% identity (69.7% similar) in 333 aa overlap (146-438:48-379)

         120       130       140       150       160       170     
pF1KB5 NIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHG
                                     :.  : : .    :.....:..  . :: :
CCDS10 SAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAG
        20        30        40        50        60        70       

         180       190       200       210       220       230     
pF1KB5 NGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVEN
       :::.:.:. : ::: ..: :.: :.:   ...::. ::..:..:.: ::.::::::. ..
CCDS10 NGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDG
        80        90       100       110       120       130       

         240       250           260       270        280       290
pF1KB5 RISICTEFMDGGSLD-VYRK---MPEHVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNML
       .:::: : ::::::: : .:   .::..::....::.::::::  . ::.::::::::.:
CCDS10 EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNIL
       140       150       160       170       180       190       

              300       310       320       330       340       350
pF1KB5 VNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELA
       ::.::..:::::::: ::..:.:...::: .::.:::..: .:...::.::.:.:..:.:
CCDS10 VNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMA
       200       210       220       230       240       250       

              360                                          370     
pF1KB5 LGRFPYPQIQKNQGSLM---------------------PL--------------QLLQCI
       .::.: :  . ..  ::                     ::              .::. :
CCDS10 VGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYI
       260       270       280       290       300       310       

         380       390       400       410       420       430     
pF1KB5 VDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVC
       :.:  : :: : ::  :  :...:. :.: ::   ..:: : :: . .:.. .  . :.:
CCDS10 VNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI-KRSDAEEVDFAGWLC
       320       330       340       350       360        370      

         440            
pF1KB5 RALEERRSQQGPP    
        ..              
CCDS10 STIGLNQPSTPTHAAGV
        380       390   

>>CCDS11686.1 MAP2K6 gene_id:5608|Hs108|chr17             (334 aa)
 initn: 765 init1: 195 opt: 783  Z-score: 543.2  bits: 109.3 E(32554): 6.1e-24
Smith-Waterman score: 783; 41.6% identity (67.7% similar) in 334 aa overlap (113-431:6-326)

             90       100       110       120       130       140  
pF1KB5 SYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPS
                                     :..   :::.  .:      .: .:.. : 
CCDS11                          MSQSKGKKRNPGLKIPKEA----FEQPQTSSTPPR
                                        10            20        30 

            150       160       170       180       190       200  
pF1KB5 NSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDIT
       .  .:.   . .   : ... .:..    ::.:  :.: :  :::::.:.::: :   ..
CCDS11 DLDSKACISIGN--QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVN
              40          50        60        70        80         

            210        220       230       240       250           
pF1KB5 LELQKQIMSELEI-LYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK-------
        . ::... .:.: .   :  . . ::::.: :. . :: :.::  ::: . :       
CCDS11 SQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQ
      90       100       110       120       130        140        

           260       270        280       290       300       310  
pF1KB5 -MPEHVLGRIAVAVVKGLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSI
        .:: .::.:::..::.: .: : :...::::::::.:.:. ::::.::::.:  ::.:.
CCDS11 TIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV
      150       160       170       180       190       200        

             320       330           340       350       360       
pF1KB5 AKTY-VGTNAYMAPERISGEQ----YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLM
       :::  .: . :::::::. :     :...::.:::::...:::. ::::     . :.  
CCDS11 AKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD----SWGT--
      210       220       230       240       250           260    

       370       380       390       400       410       420       
pF1KB5 PLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNA
       :.: :. .:.: :: ::. .::  :: : .::..:. ::::.  ::: :::..  .. ..
CCDS11 PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT
            270       280       290       300       310       320  

       430       440        
pF1KB5 AVVSMWVCRALEERRSQQGPP
        :.:                 
CCDS11 DVASFVKLILGD         
            330             

>>CCDS12120.1 MAP2K2 gene_id:5605|Hs108|chr19             (400 aa)
 initn: 712 init1: 388 opt: 781  Z-score: 541.0  bits: 109.1 E(32554): 8.2e-24
Smith-Waterman score: 849; 40.7% identity (68.8% similar) in 337 aa overlap (146-438:52-387)

         120       130       140       150       160       170     
pF1KB5 NIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHG
                                     :.  : : .    :.....:..  . :: :
CCDS12 PSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAG
              30        40        50        60        70        80 

         180       190       200       210       220       230     
pF1KB5 NGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVEN
       :::.: :. : ::: :.: :.: :.:   ...::. ::..:..:.: ::.::::::. ..
CCDS12 NGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDG
              90       100       110       120       130       140 

         240       250           260       270        280       290
pF1KB5 RISICTEFMDGGSLDVY----RKMPEHVLGRIAVAVVKGLTYLW-SLKILHRDVKPSNML
       .:::: : :::::::      ...::..::....::..::.::  . .:.::::::::.:
CCDS12 EISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNIL
             150       160       170       180       190       200 

              300       310       320       330       340       350
pF1KB5 VNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELA
       ::.::..:::::::: ::..:.:...::: .::::::..: .:...::.::.:.:..:::
CCDS12 VNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELA
             210       220       230       240       250       260 

                            360                                370 
pF1KB5 LGRFPYPQ--------------IQKNQG---SLMP----------------------LQL
       .::.: :               .. ..:   :. :                      ..:
CCDS12 VGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFEL
             270       280       290       300       310       320 

             380       390       400       410       420       430 
pF1KB5 LQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVS
       :. ::.:  : :: : :.  : .:...:. :.: ::   . : .: :: . .. . .  .
CCDS12 LDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFI-KRSEVEEVDFA
             330       340       350       360        370       380

             440           
pF1KB5 MWVCRALEERRSQQGPP   
        :.:..:             
CCDS12 GWLCKTLRLNQPGTPTRTAV
              390       400

>>CCDS82194.1 MAP2K6 gene_id:5608|Hs108|chr17             (278 aa)
 initn: 765 init1: 195 opt: 764  Z-score: 531.6  bits: 106.9 E(32554): 2.7e-23
Smith-Waterman score: 764; 46.5% identity (71.3% similar) in 275 aa overlap (172-431:3-270)

             150       160       170       180       190       200 
pF1KB5 SNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDI
                                     ::.:  :.: :  :::::.:.::: :   .
CCDS82                             MELGRGAYGVVEKMRHVPSGQIMAVKRIRATV
                                           10        20        30  

             210        220       230       240       250          
pF1KB5 TLELQKQIMSELEI-LYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK------
       . . ::... .:.: .   :  . . ::::.: :. . :: :.::  ::: . :      
CCDS82 NSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKG
             40        50        60        70         80        90 

            260       270        280       290       300       310 
pF1KB5 --MPEHVLGRIAVAVVKGLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNS
         .:: .::.:::..::.: .: : :...::::::::.:.:. ::::.::::.:  ::.:
CCDS82 QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS
             100       110       120       130       140       150 

              320       330           340       350       360      
pF1KB5 IAKTY-VGTNAYMAPERISGEQ----YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSL
       .:::  .: . :::::::. :     :...::.:::::...:::. ::::     . :. 
CCDS82 VAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD----SWGT-
             160       170       180       190       200           

        370       380       390       400       410       420      
pF1KB5 MPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGN
        :.: :. .:.: :: ::. .::  :: : .::..:. ::::.  ::: :::..  .. .
CCDS82 -PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKG
         210       220       230       240       250       260     

        430       440        
pF1KB5 AAVVSMWVCRALEERRSQQGPP
       . :.:                 
CCDS82 TDVASFVKLILGD         
         270                 

>>CCDS11218.1 MAP2K3 gene_id:5606|Hs108|chr17             (318 aa)
 initn: 733 init1: 188 opt: 638  Z-score: 447.8  bits: 91.6 E(32554): 1.3e-18
Smith-Waterman score: 739; 43.7% identity (68.5% similar) in 302 aa overlap (132-418:2-295)

             110       120       130       140       150       160 
pF1KB5 LQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQM
                                     :.: . .  :  .:  : . .     : ..
CCDS11                              MSKPPAPNPTPPRNLD-SRTFITIGDRNFEV
                                            10         20        30

             170       180       190       200       210        220
pF1KB5 NEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-LYKCD
       . .:.   . ::.:  :.: :. :. :: :.::: :   .. . ::... .:.: .   :
CCDS11 EADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVD
               40        50        60        70        80        90

              230       240       250               260       270  
pF1KB5 SSYIIGFYGAFFVENRISICTEFMDGGSLD-VYRK-------MPEHVLGRIAVAVVKGLT
         : . ::::.: :. . :: :.::  :::  :::       .:: .::.:::..:..: 
CCDS11 CFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALE
              100       110        120       130       140         

             280       290       300       310        320       330
pF1KB5 YLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERISG
       .: : :...::::::::.:.: .:.::.::::.:  ::.:.:::. .: . :::::::. 
CCDS11 HLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINP
     150       160       170       180       190       200         

                  340       350       360       370       380      
pF1KB5 EQ----YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVG
       :     :...::::::::...:.:. ::::    .. :.  :.: :. .:.: :: ::. 
CCDS11 ELNQKGYNVKSDVWSLGITMIEMAILRFPY----ESWGT--PFQQLKQVVEEPSPQLPAD
     210       220       230           240         250       260   

        390       400       410       420       430       440      
pF1KB5 EFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQG
       .::  :: : .::.::.: :: .  ::: :::                            
CCDS11 RFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS     
           270       280       290       300       310             

         
pF1KB5 PP

>>CCDS11217.1 MAP2K3 gene_id:5606|Hs108|chr17             (347 aa)
 initn: 733 init1: 188 opt: 638  Z-score: 447.4  bits: 91.6 E(32554): 1.3e-18
Smith-Waterman score: 741; 41.7% identity (65.9% similar) in 331 aa overlap (106-418:4-324)

          80        90       100       110          120       130  
pF1KB5 EEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKP---PGERNIHGLKVNTRAGPSQHS
                                     : . .:   :  ..    : . :   :  :
CCDS11                            MESPASSQPASMPQSKGKSKRKKDLRI--SCMS
                                          10        20          30 

            140       150       160       170       180       190  
pF1KB5 SPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKIL
       .: . .  :  .:  : . .     : ... .:.   . ::.:  :.: :. :. :: :.
CCDS11 KPPAPNPTPPRNLD-SRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIM
              40         50        60        70        80        90

            200       210        220       230       240       250 
pF1KB5 AVKVILLDITLELQKQIMSELEI-LYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLD-
       ::: :   .. . ::... .:.: .   :  : . ::::.: :. . :: :.::  ::: 
CCDS11 AVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDK
              100       110       120       130       140          

                     260       270        280       290       300  
pF1KB5 VYRK-------MPEHVLGRIAVAVVKGLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDF
        :::       .:: .::.:::..:..: .: : :...::::::::.:.: .:.::.:::
CCDS11 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF
     150       160       170       180       190       200         

            310        320       330           340       350       
pF1KB5 GVSTQLVNSIAKTY-VGTNAYMAPERISGEQ----YGIHSDVWSLGISFMELALGRFPYP
       :.:  ::.:.:::. .: . :::::::. :     :...::::::::...:.:. :::: 
CCDS11 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPY-
     210       220       230       240       250       260         

       360       370       380       390       400       410       
pF1KB5 QIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHP
          .. :.  :.: :. .:.: :: ::. .::  :: : .::.::.: :: .  ::: ::
CCDS11 ---ESWGT--PFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHP
         270         280       290       300       310       320   

       420       430       440        
pF1KB5 FIVQFNDGNAAVVSMWVCRALEERRSQQGPP
       :                              
CCDS11 FFTLHKTKKTDIAAFVKEILGEDS       
           330       340              

>>CCDS42491.1 MAP2K7 gene_id:5609|Hs108|chr19             (419 aa)
 initn: 459 init1: 185 opt: 618  Z-score: 433.2  bits: 89.3 E(32554): 8.2e-18
Smith-Waterman score: 620; 34.5% identity (64.1% similar) in 357 aa overlap (106-443:62-403)

          80        90       100       110        120       130    
pF1KB5 EEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGE-RNIHGLKVNTRAGPSQHSSP
                                     :.   ::.. :.. ::       ::   .:
CCDS42 LDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGL-------PSTLFTP
              40        50        60        70               80    

          140        150       160       170          180       190
pF1KB5 AVSDSLP-SNSLKKSSAELKKILANGQMNEQDIRYRDTLGH-GNG--GTVYKAYHVPSGK
          .:.  ...:..   .   .  .::  . .:   ..::. :.:  : :.:     .:.
CCDS42 RSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGH
           90       100       110       120       130       140    

              200       210        220       230       240         
pF1KB5 ILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIGFYGAFFVENRISICTEFMDGGSL
       ..::: .  . . : .:.:. .:... :  :  ::.  .:.:.... . :  :.:   . 
CCDS42 VIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAE
          150       160       170       180       190       200    

     250           260       270        280       290       300    
pF1KB5 DVYRKM----PEHVLGRIAVAVVKGLTYLWSLK-ILHRDVKPSNMLVNTRGQVKLCDFGV
        . ..:    ::..::...::.::.: ::   . ..::::::::.:.. :::.::::::.
CCDS42 KLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGI
          210       220       230       240       250       260    

          310        320            330       340       350        
pF1KB5 STQLVNSIAKTY-VGTNAYMAPERI-----SGEQYGIHSDVWSLGISFMELALGRFPYPQ
       : .::.: :::  .:  ::::::::     .  .: :..::::::::..::: :.::: .
CCDS42 SGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKN
          270       280       290       300       310       320    

      360       370       380         390       400       410      
pF1KB5 IQKNQGSLMPLQLLQCIVDEDSPVLP--VGEFSEPFVHFITQCMRKQPKERPAPEELMGH
        . .      ...:  ...:. :.::  .: ::  :  :. .:. :. ..::  ..:. :
CCDS42 CKTD------FEVLTKVLQEEPPLLPGHMG-FSGDFQSFVKDCLTKDHRKRPKYNKLLEH
                330       340        350       360       370       

        420       430       440                   
pF1KB5 PFIVQFNDGNAAVVSMWVCRALEERRSQQGPP           
        :: ...  .. :.: :   .. . .:                
CCDS42 SFIKRYETLEVDVAS-WFKDVMAKTESPRTSGVLSQPHLPFFR
       380       390        400       410         




448 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 15:47:11 2016 done: Thu Nov  3 15:47:11 2016
 Total Scan time:  3.090 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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