Result of FASTA (omim) for pF1KB4573
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4573, 648 aa
  1>>>pF1KB4573 648 - 648 aa - 648 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.9707+/-0.000656; mu= 0.4953+/- 0.040
 mean_var=774.3879+/-177.500, 0's: 0 Z-trim(116.0): 1475  B-trim: 0 in 0/56
 Lambda= 0.046089
 statistics sampled from 24804 (26793) to 24804 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.655), E-opt: 0.2 (0.314), width:  16
 Scan time: 11.080

The best scores are:                                      opt bits E(85289)
XP_011532276 (OMIM: 164760,611553,611554,615916) P ( 648) 4370 307.4   1e-82
XP_005265412 (OMIM: 164760,611553,611554,615916) P ( 648) 4370 307.4   1e-82
NP_002871 (OMIM: 164760,611553,611554,615916) RAF  ( 648) 4370 307.4   1e-82
XP_011532277 (OMIM: 164760,611553,611554,615916) P ( 567) 3634 258.4 5.2e-68
XP_005265415 (OMIM: 164760,611553,611554,615916) P ( 567) 3634 258.4 5.2e-68
XP_005265416 (OMIM: 164760,611553,611554,615916) P ( 534) 2800 202.9 2.5e-51
XP_005265414 (OMIM: 164760,611553,611554,615916) P ( 615) 2800 203.0 2.7e-51
XP_016862455 (OMIM: 164760,611553,611554,615916) P ( 615) 2800 203.0 2.7e-51
NP_001645 (OMIM: 311010) serine/threonine-protein  ( 606) 2457 180.2 1.9e-44
XP_011542210 (OMIM: 311010) PREDICTED: serine/thre ( 606) 2457 180.2 1.9e-44
XP_006724592 (OMIM: 311010) PREDICTED: serine/thre ( 611) 2451 179.8 2.6e-44
XP_011542208 (OMIM: 311010) PREDICTED: serine/thre ( 611) 2451 179.8 2.6e-44
NP_001243125 (OMIM: 311010) serine/threonine-prote ( 609) 2449 179.6 2.8e-44
NP_004324 (OMIM: 115150,163950,164757,211980,61370 ( 766) 1797 136.5 3.5e-31
XP_005250102 (OMIM: 115150,163950,164757,211980,61 ( 767) 1797 136.5 3.5e-31
XP_011542211 (OMIM: 311010) PREDICTED: serine/thre ( 387) 1744 132.4 2.9e-30
XP_016868047 (OMIM: 115150,163950,164757,211980,61 ( 807) 1738 132.6 5.4e-30
XP_016868048 (OMIM: 115150,163950,164757,211980,61 ( 798) 1581 122.1 7.5e-27
NP_001243126 (OMIM: 311010) serine/threonine-prote ( 186)  645 58.8 2.1e-08
XP_016866143 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537)  535 52.3 5.4e-06
XP_016866139 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537)  535 52.3 5.4e-06
XP_016866140 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537)  535 52.3 5.4e-06
XP_016866142 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537)  535 52.3 5.4e-06
XP_016866141 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537)  535 52.3 5.4e-06
NP_002028 (OMIM: 137025) tyrosine-protein kinase F ( 537)  535 52.3 5.4e-06
XP_016881449 (OMIM: 164880) PREDICTED: tyrosine-pr ( 543)  527 51.8 7.9e-06
NP_005424 (OMIM: 164880) tyrosine-protein kinase Y ( 543)  527 51.8 7.9e-06
XP_011527315 (OMIM: 114500,190090,616937) PREDICTE ( 536)  523 51.5 9.4e-06
NP_005408 (OMIM: 114500,190090,616937) proto-oncog ( 536)  523 51.5 9.4e-06
NP_938033 (OMIM: 114500,190090,616937) proto-oncog ( 536)  523 51.5 9.4e-06
XP_016883516 (OMIM: 114500,190090,616937) PREDICTE ( 542)  523 51.5 9.4e-06
XP_016883513 (OMIM: 114500,190090,616937) PREDICTE ( 542)  523 51.5 9.4e-06
XP_016883515 (OMIM: 114500,190090,616937) PREDICTE ( 542)  523 51.5 9.4e-06
XP_016883514 (OMIM: 114500,190090,616937) PREDICTE ( 542)  523 51.5 9.4e-06
XP_011533958 (OMIM: 606573) PREDICTED: tyrosine-pr ( 392)  517 50.8 1.1e-05
XP_005266947 (OMIM: 137025) PREDICTED: tyrosine-pr ( 534)  519 51.2 1.1e-05
NP_694592 (OMIM: 137025) tyrosine-protein kinase F ( 534)  519 51.2 1.1e-05
XP_005266937 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505)  517 51.0 1.2e-05
XP_011533956 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505)  517 51.0 1.2e-05
XP_005266939 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505)  517 51.0 1.2e-05
NP_002022 (OMIM: 606573) tyrosine-protein kinase F ( 505)  517 51.0 1.2e-05
XP_011533955 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505)  517 51.0 1.2e-05
XP_011533957 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505)  517 51.0 1.2e-05
XP_016866134 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505)  517 51.0 1.2e-05
XP_005266938 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505)  517 51.0 1.2e-05
XP_016874699 (OMIM: 610737) PREDICTED: kinase supp ( 515)  511 50.7 1.6e-05
XP_011536530 (OMIM: 610737) PREDICTED: kinase supp ( 647)  511 50.8 1.8e-05
XP_011536527 (OMIM: 610737) PREDICTED: kinase supp ( 829)  511 51.0   2e-05
NP_775869 (OMIM: 610737) kinase suppressor of Ras  ( 921)  511 51.1 2.1e-05
XP_011536526 (OMIM: 610737) PREDICTED: kinase supp ( 948)  511 51.1 2.1e-05


>>XP_011532276 (OMIM: 164760,611553,611554,615916) PREDI  (648 aa)
 initn: 4370 init1: 4370 opt: 4370  Z-score: 1606.0  bits: 307.4 E(85289): 1e-82
Smith-Waterman score: 4370; 100.0% identity (100.0% similar) in 648 aa overlap (1-648:1-648)

               10        20        30        40        50        60
pF1KB4 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
              550       560       570       580       590       600

              610       620       630       640        
pF1KB4 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
       ::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
              610       620       630       640        

>>XP_005265412 (OMIM: 164760,611553,611554,615916) PREDI  (648 aa)
 initn: 4370 init1: 4370 opt: 4370  Z-score: 1606.0  bits: 307.4 E(85289): 1e-82
Smith-Waterman score: 4370; 100.0% identity (100.0% similar) in 648 aa overlap (1-648:1-648)

               10        20        30        40        50        60
pF1KB4 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
              550       560       570       580       590       600

              610       620       630       640        
pF1KB4 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
       ::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
              610       620       630       640        

>>NP_002871 (OMIM: 164760,611553,611554,615916) RAF prot  (648 aa)
 initn: 4370 init1: 4370 opt: 4370  Z-score: 1606.0  bits: 307.4 E(85289): 1e-82
Smith-Waterman score: 4370; 100.0% identity (100.0% similar) in 648 aa overlap (1-648:1-648)

               10        20        30        40        50        60
pF1KB4 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
              550       560       570       580       590       600

              610       620       630       640        
pF1KB4 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
       ::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
              610       620       630       640        

>>XP_011532277 (OMIM: 164760,611553,611554,615916) PREDI  (567 aa)
 initn: 3634 init1: 3634 opt: 3634  Z-score: 1342.0  bits: 258.4 E(85289): 5.2e-68
Smith-Waterman score: 3634; 100.0% identity (100.0% similar) in 541 aa overlap (108-648:27-567)

        80        90       100       110       120       130       
pF1KB4 LHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLT
                                     ::::::::::::::::::::::::::::::
XP_011     MMANSQILLRQATLSVFSCRTSKEQCKKARLDWNTDAASLIGEELQVDFLDHVPLT
                   10        20        30        40        50      

       140       150       160       170       180       190       
pF1KB4 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFP
         60        70        80        90       100       110      

       200       210       220       230       240       250       
pF1KB4 NSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRS
        120       130       140       150       160       170      

       260       270       280       290       300       310       
pF1KB4 TSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE
        180       190       200       210       220       230      

       320       330       340       350       360       370       
pF1KB4 RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
        240       250       260       270       280       290      

       380       390       400       410       420       430       
pF1KB4 KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
        300       310       320       330       340       350      

       440       450       460       470       480       490       
pF1KB4 TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS
        360       370       380       390       400       410      

       500       510       520       530       540       550       
pF1KB4 GSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
        420       430       440       450       460       470      

       560       570       580       590       600       610       
pF1KB4 IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKIN
        480       490       500       510       520       530      

       620       630       640        
pF1KB4 RSASEPSLHRAAHTEDINACTLTTSPRLPVF
       :::::::::::::::::::::::::::::::
XP_011 RSASEPSLHRAAHTEDINACTLTTSPRLPVF
        540       550       560       

>>XP_005265415 (OMIM: 164760,611553,611554,615916) PREDI  (567 aa)
 initn: 3634 init1: 3634 opt: 3634  Z-score: 1342.0  bits: 258.4 E(85289): 5.2e-68
Smith-Waterman score: 3634; 100.0% identity (100.0% similar) in 541 aa overlap (108-648:27-567)

        80        90       100       110       120       130       
pF1KB4 LHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLT
                                     ::::::::::::::::::::::::::::::
XP_005     MMANSQILLRQATLSVFSCRTSKEQCKKARLDWNTDAASLIGEELQVDFLDHVPLT
                   10        20        30        40        50      

       140       150       160       170       180       190       
pF1KB4 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFP
         60        70        80        90       100       110      

       200       210       220       230       240       250       
pF1KB4 NSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRS
        120       130       140       150       160       170      

       260       270       280       290       300       310       
pF1KB4 TSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE
        180       190       200       210       220       230      

       320       330       340       350       360       370       
pF1KB4 RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
        240       250       260       270       280       290      

       380       390       400       410       420       430       
pF1KB4 KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
        300       310       320       330       340       350      

       440       450       460       470       480       490       
pF1KB4 TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS
        360       370       380       390       400       410      

       500       510       520       530       540       550       
pF1KB4 GSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
        420       430       440       450       460       470      

       560       570       580       590       600       610       
pF1KB4 IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKIN
        480       490       500       510       520       530      

       620       630       640        
pF1KB4 RSASEPSLHRAAHTEDINACTLTTSPRLPVF
       :::::::::::::::::::::::::::::::
XP_005 RSASEPSLHRAAHTEDINACTLTTSPRLPVF
        540       550       560       

>>XP_005265416 (OMIM: 164760,611553,611554,615916) PREDI  (534 aa)
 initn: 3402 init1: 2800 opt: 2800  Z-score: 1042.5  bits: 202.9 E(85289): 2.5e-51
Smith-Waterman score: 3340; 93.7% identity (93.9% similar) in 541 aa overlap (108-648:27-534)

        80        90       100       110       120       130       
pF1KB4 LHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLT
                                     ::::::::::::::::::::::::::::::
XP_005     MMANSQILLRQATLSVFSCRTSKEQCKKARLDWNTDAASLIGEELQVDFLDHVPLT
                   10        20        30        40        50      

       140       150       160       170       180       190       
pF1KB4 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.   
XP_005 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLF---
         60        70        80        90       100       110      

       200       210       220       230       240       250       
pF1KB4 NSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRS
                                     ::::::::::::::::::::::::::::::
XP_005 ------------------------------SQHRYSTPHAFTFNTSSPSSEGSLSQRQRS
                                         120       130       140   

       260       270       280       290       300       310       
pF1KB4 TSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE
           150       160       170       180       190       200   

       320       330       340       350       360       370       
pF1KB4 RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
           210       220       230       240       250       260   

       380       390       400       410       420       430       
pF1KB4 KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
           270       280       290       300       310       320   

       440       450       460       470       480       490       
pF1KB4 TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS
           330       340       350       360       370       380   

       500       510       520       530       540       550       
pF1KB4 GSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
           390       400       410       420       430       440   

       560       570       580       590       600       610       
pF1KB4 IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKIN
           450       460       470       480       490       500   

       620       630       640        
pF1KB4 RSASEPSLHRAAHTEDINACTLTTSPRLPVF
       :::::::::::::::::::::::::::::::
XP_005 RSASEPSLHRAAHTEDINACTLTTSPRLPVF
           510       520       530    

>>XP_005265414 (OMIM: 164760,611553,611554,615916) PREDI  (615 aa)
 initn: 4138 init1: 2800 opt: 2800  Z-score: 1042.0  bits: 203.0 E(85289): 2.7e-51
Smith-Waterman score: 4076; 94.8% identity (94.9% similar) in 648 aa overlap (1-648:1-615)

               10        20        30        40        50        60
pF1KB4 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
       :::::::::::::.                                 :::::::::::::
XP_005 PTMCVDWSNIRQLF---------------------------------SQHRYSTPHAFTF
              190                                        200       

              250       260       270       280       290       300
pF1KB4 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
       210       220       230       240       250       260       

              310       320       330       340       350       360
pF1KB4 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
       270       280       290       300       310       320       

              370       380       390       400       410       420
pF1KB4 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
       330       340       350       360       370       380       

              430       440       450       460       470       480
pF1KB4 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
       390       400       410       420       430       440       

              490       500       510       520       530       540
pF1KB4 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
       450       460       470       480       490       500       

              550       560       570       580       590       600
pF1KB4 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
       510       520       530       540       550       560       

              610       620       630       640        
pF1KB4 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
       ::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
       570       580       590       600       610     

>>XP_016862455 (OMIM: 164760,611553,611554,615916) PREDI  (615 aa)
 initn: 4138 init1: 2800 opt: 2800  Z-score: 1042.0  bits: 203.0 E(85289): 2.7e-51
Smith-Waterman score: 4076; 94.8% identity (94.9% similar) in 648 aa overlap (1-648:1-615)

               10        20        30        40        50        60
pF1KB4 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
       :::::::::::::.                                 :::::::::::::
XP_016 PTMCVDWSNIRQLF---------------------------------SQHRYSTPHAFTF
              190                                        200       

              250       260       270       280       290       300
pF1KB4 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
       210       220       230       240       250       260       

              310       320       330       340       350       360
pF1KB4 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
       270       280       290       300       310       320       

              370       380       390       400       410       420
pF1KB4 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
       330       340       350       360       370       380       

              430       440       450       460       470       480
pF1KB4 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
       390       400       410       420       430       440       

              490       500       510       520       530       540
pF1KB4 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
       450       460       470       480       490       500       

              550       560       570       580       590       600
pF1KB4 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
       510       520       530       540       550       560       

              610       620       630       640        
pF1KB4 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
       ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
       570       580       590       600       610     

>>NP_001645 (OMIM: 311010) serine/threonine-protein kina  (606 aa)
 initn: 2208 init1: 1617 opt: 2457  Z-score: 918.8  bits: 180.2 E(85289): 1.9e-44
Smith-Waterman score: 2457; 62.1% identity (81.1% similar) in 607 aa overlap (50-646:13-606)

      20        30        40        50        60        70         
pF1KB4 AVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLH
                                     .::.. .:..:.:::::::::.::.:::..
NP_001                   MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVY
                                 10        20        30        40  

      80        90       100       110       120       130         
pF1KB4 DCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTH
       : : ::::::::. .::.:.::.   ::.:.   :.:  : : :::: :. :. :::: :
NP_001 DSLDKALKVRGLNQDCCVVYRLI---KGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMH
             50        60           70        80        90         

     140       150       160       170       180       190         
pF1KB4 NFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNS
       ::.::::..:::::.: :::..::::::::::::.:::.::::.::: :. :: .    .
NP_001 NFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQ
     100       110       120       130       140       150         

     200        210       220       230       240       250        
pF1KB4 TI-GDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRST
        . : :     ::   : . : .. .  : . ..  :. : :    :.  ..  :: :::
NP_001 DLSGGSRQHEAPS--NRPLNELLTPQGPSPRTQHCDPEHFPF----PAPANAPLQRIRST
     160       170         180       190           200       210   

      260       270               280       290       300       310
pF1KB4 STPNVHMVSTTLPVDSRMIE--------DAIRSHSESASPSALSSSPNNLSPTGWSQPKT
       ::::::::::: :.:: .:.        ::  :.. : .    : :: ..: .: ..:..
NP_001 STPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVS-SGRKSPHS
           220       230       240       250       260        270  

               320       330       340       350       360         
pF1KB4 PVPA-QRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWH
         :: ::::   : ...:.:..  : :::.::::.  :::.:  :::.::::::..:.::
NP_001 KSPAEQRERK--SLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWH
            280         290       300       310       320       330

     370       380       390       400       410       420         
pF1KB4 GDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSL
       ::::::.::: .:: :: :::.::. :::::::::::::::.::. ..::.:::::::::
NP_001 GDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSL
              340       350       360       370       380       390

     430       440       450       460       470       480         
pF1KB4 YKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGL
       :.:::: .:.:.: ::::.::::::::::::::::::::.::::::::::::::::::::
NP_001 YHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGL
              400       410       420       430       440       450

     490       500       510       520       530       540         
pF1KB4 ATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYS
       ::::.::::.: .:::.::::::: ::::::: ::.:::::::.::.:::::::: ::::
NP_001 ATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYS
              460       470       480       490       500       510

     550       560       570       580       590       600         
pF1KB4 HINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELL
       ::. :::::::::::: ::::::. .::::::.::..::.:  .::::::::::..::::
NP_001 HIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELL
              520       530       540       550       560       570

     610       620       630       640        
pF1KB4 QHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
       :.:::::.::::::::::. ..... :: :...  .:  
NP_001 QRSLPKIERSASEPSLHRT-QADELPACLLSAARLVP  
              580        590       600        

>>XP_011542210 (OMIM: 311010) PREDICTED: serine/threonin  (606 aa)
 initn: 2208 init1: 1617 opt: 2457  Z-score: 918.8  bits: 180.2 E(85289): 1.9e-44
Smith-Waterman score: 2457; 62.1% identity (81.1% similar) in 607 aa overlap (50-646:13-606)

      20        30        40        50        60        70         
pF1KB4 AVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLH
                                     .::.. .:..:.:::::::::.::.:::..
XP_011                   MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVY
                                 10        20        30        40  

      80        90       100       110       120       130         
pF1KB4 DCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTH
       : : ::::::::. .::.:.::.   ::.:.   :.:  : : :::: :. :. :::: :
XP_011 DSLDKALKVRGLNQDCCVVYRLI---KGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMH
             50        60           70        80        90         

     140       150       160       170       180       190         
pF1KB4 NFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNS
       ::.::::..:::::.: :::..::::::::::::.:::.::::.::: :. :: .    .
XP_011 NFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQ
     100       110       120       130       140       150         

     200        210       220       230       240       250        
pF1KB4 TI-GDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRST
        . : :     ::   : . : .. .  : . ..  :. : :    :.  ..  :: :::
XP_011 DLSGGSRQHEAPS--NRPLNELLTPQGPSPRTQHCDPEHFPF----PAPANAPLQRIRST
     160       170         180       190           200       210   

      260       270               280       290       300       310
pF1KB4 STPNVHMVSTTLPVDSRMIE--------DAIRSHSESASPSALSSSPNNLSPTGWSQPKT
       ::::::::::: :.:: .:.        ::  :.. : .    : :: ..: .: ..:..
XP_011 STPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVS-SGRKSPHS
           220       230       240       250       260        270  

               320       330       340       350       360         
pF1KB4 PVPA-QRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWH
         :: ::::   : ...:.:..  : :::.::::.  :::.:  :::.::::::..:.::
XP_011 KSPAEQRERK--SLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWH
            280         290       300       310       320       330

     370       380       390       400       410       420         
pF1KB4 GDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSL
       ::::::.::: .:: :: :::.::. :::::::::::::::.::. ..::.:::::::::
XP_011 GDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSL
              340       350       360       370       380       390

     430       440       450       460       470       480         
pF1KB4 YKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGL
       :.:::: .:.:.: ::::.::::::::::::::::::::.::::::::::::::::::::
XP_011 YHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGL
              400       410       420       430       440       450

     490       500       510       520       530       540         
pF1KB4 ATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYS
       ::::.::::.: .:::.::::::: ::::::: ::.:::::::.::.:::::::: ::::
XP_011 ATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYS
              460       470       480       490       500       510

     550       560       570       580       590       600         
pF1KB4 HINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELL
       ::. :::::::::::: ::::::. .::::::.::..::.:  .::::::::::..::::
XP_011 HIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELL
              520       530       540       550       560       570

     610       620       630       640        
pF1KB4 QHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
       :.:::::.::::::::::. ..... :: :...  .:  
XP_011 QRSLPKIERSASEPSLHRT-QADELPACLLSAARLVP  
              580        590       600        




648 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 15:10:26 2016 done: Thu Nov  3 15:10:27 2016
 Total Scan time: 11.080 Total Display time:  0.150

Function used was FASTA [36.3.4 Apr, 2011]
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