Result of FASTA (omim) for pF1KB4447
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4447, 427 aa
  1>>>pF1KB4447 427 - 427 aa - 427 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.2629+/-0.000454; mu= 6.1408+/- 0.028
 mean_var=499.6810+/-111.058, 0's: 0 Z-trim(120.8): 1795  B-trim: 0 in 0/57
 Lambda= 0.057376
 statistics sampled from 33917 (36424) to 33917 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.766), E-opt: 0.2 (0.427), width:  16
 Scan time:  9.340

The best scores are:                                      opt bits E(85289)
NP_057360 (OMIM: 607589) serine/threonine-protein  ( 427) 2981 261.6 2.7e-69
NP_001186193 (OMIM: 607589) serine/threonine-prote ( 367) 2506 222.2 1.7e-57
NP_733794 (OMIM: 607589) serine/threonine-protein  ( 367) 2506 222.2 1.7e-57
NP_005618 (OMIM: 602958) serine/threonine-protein  ( 431) 1818 165.4 2.6e-40
NP_001137150 (OMIM: 602958) serine/threonine-prote ( 445) 1818 165.4 2.6e-40
NP_001137149 (OMIM: 602958) serine/threonine-prote ( 459) 1818 165.4 2.7e-40
NP_001137148 (OMIM: 602958) serine/threonine-prote ( 526) 1818 165.5 2.8e-40
XP_011534373 (OMIM: 602958) PREDICTED: serine/thre ( 526) 1818 165.5 2.8e-40
NP_001028750 (OMIM: 607591) serine/threonine-prote ( 496) 1691 155.0   4e-37
NP_037389 (OMIM: 607591) serine/threonine-protein  ( 496) 1691 155.0   4e-37
NP_001278924 (OMIM: 602958) serine/threonine-prote ( 387) 1252 118.4 3.1e-26
XP_016855474 (OMIM: 611223,615937) PREDICTED: RAC- ( 418) 1140 109.2   2e-23
NP_001193658 (OMIM: 611223,615937) RAC-gamma serin ( 465) 1140 109.3 2.1e-23
NP_859029 (OMIM: 611223,615937) RAC-gamma serine/t ( 465) 1140 109.3 2.1e-23
XP_005273052 (OMIM: 611223,615937) PREDICTED: RAC- ( 479) 1140 109.3 2.1e-23
NP_005456 (OMIM: 611223,615937) RAC-gamma serine/t ( 479) 1140 109.3 2.1e-23
XP_005273051 (OMIM: 611223,615937) PREDICTED: RAC- ( 479) 1140 109.3 2.1e-23
NP_001229956 (OMIM: 125853,164731,240900) RAC-beta ( 419) 1128 108.2   4e-23
NP_001229957 (OMIM: 125853,164731,240900) RAC-beta ( 419) 1128 108.2   4e-23
XP_011524918 (OMIM: 125853,164731,240900) PREDICTE ( 481) 1128 108.3 4.2e-23
XP_011524921 (OMIM: 125853,164731,240900) PREDICTE ( 481) 1128 108.3 4.2e-23
NP_001617 (OMIM: 125853,164731,240900) RAC-beta se ( 481) 1128 108.3 4.2e-23
XP_011524916 (OMIM: 125853,164731,240900) PREDICTE ( 481) 1128 108.3 4.2e-23
XP_016881959 (OMIM: 125853,164731,240900) PREDICTE ( 481) 1128 108.3 4.2e-23
XP_011524922 (OMIM: 125853,164731,240900) PREDICTE ( 481) 1128 108.3 4.2e-23
XP_011524920 (OMIM: 125853,164731,240900) PREDICTE ( 481) 1128 108.3 4.2e-23
XP_011524917 (OMIM: 125853,164731,240900) PREDICTE ( 481) 1128 108.3 4.2e-23
NP_001014432 (OMIM: 114480,114500,164730,167000,17 ( 480) 1117 107.4   8e-23
NP_005154 (OMIM: 114480,114500,164730,167000,17692 ( 480) 1117 107.4   8e-23
XP_005267458 (OMIM: 114480,114500,164730,167000,17 ( 480) 1117 107.4   8e-23
NP_001014431 (OMIM: 114480,114500,164730,167000,17 ( 480) 1117 107.4   8e-23
XP_011542314 (OMIM: 611223,615937) PREDICTED: RAC- ( 435) 1058 102.5 2.2e-21
NP_003943 (OMIM: 608939) ribosomal protein S6 kina ( 482) 1023 99.7 1.8e-20
XP_016876566 (OMIM: 114480,114500,164730,167000,17 ( 530) 1014 99.0 3.1e-20
XP_016876567 (OMIM: 114480,114500,164730,167000,17 ( 530) 1014 99.0 3.1e-20
XP_016876564 (OMIM: 114480,114500,164730,167000,17 ( 530) 1014 99.0 3.1e-20
XP_016876565 (OMIM: 114480,114500,164730,167000,17 ( 530) 1014 99.0 3.1e-20
NP_001258972 (OMIM: 608938) ribosomal protein S6 k ( 451) 1011 98.6 3.4e-20
NP_001258973 (OMIM: 608938) ribosomal protein S6 k ( 472) 1011 98.6 3.5e-20
NP_001258989 (OMIM: 608938) ribosomal protein S6 k ( 502) 1011 98.7 3.6e-20
NP_003152 (OMIM: 608938) ribosomal protein S6 kina ( 525) 1011 98.7 3.6e-20
NP_733827 (OMIM: 607591) serine/threonine-protein  ( 464) 1009 98.5 3.9e-20
XP_011531285 (OMIM: 176975) PREDICTED: protein kin ( 436) 1002 97.8 5.6e-20
XP_006712113 (OMIM: 176975) PREDICTED: protein kin ( 460) 1002 97.9 5.7e-20
XP_011531284 (OMIM: 176975) PREDICTED: protein kin ( 497) 1002 97.9 5.9e-20
XP_016859978 (OMIM: 176975) PREDICTED: protein kin ( 587) 1002 98.1 6.4e-20
XP_011531283 (OMIM: 176975) PREDICTED: protein kin ( 587) 1002 98.1 6.4e-20
XP_016859979 (OMIM: 176975) PREDICTED: protein kin ( 587) 1002 98.1 6.4e-20
XP_016859980 (OMIM: 176975) PREDICTED: protein kin ( 587) 1002 98.1 6.4e-20
XP_011531282 (OMIM: 176975) PREDICTED: protein kin ( 587) 1002 98.1 6.4e-20


>>NP_057360 (OMIM: 607589) serine/threonine-protein kina  (427 aa)
 initn: 2981 init1: 2981 opt: 2981  Z-score: 1365.1  bits: 261.6 E(85289): 2.7e-69
Smith-Waterman score: 2981; 100.0% identity (100.0% similar) in 427 aa overlap (1-427:1-427)

               10        20        30        40        50        60
pF1KB4 MQGLLTSGRKPSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MQGLLTSGRKPSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE
              370       380       390       400       410       420

              
pF1KB4 DDDILDC
       :::::::
NP_057 DDDILDC
              

>>NP_001186193 (OMIM: 607589) serine/threonine-protein k  (367 aa)
 initn: 2506 init1: 2506 opt: 2506  Z-score: 1153.1  bits: 222.2 E(85289): 1.7e-57
Smith-Waterman score: 2506; 100.0% identity (100.0% similar) in 367 aa overlap (61-427:1-367)

               40        50        60        70        80        90
pF1KB4 PWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNA
                                     ::::::::::::::::::::::::::::::
NP_001                               MNSSPAGTPSPQPSRANGNINLGPSANPNA
                                             10        20        30

              100       110       120       130       140       150
pF1KB4 QPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKN
               40        50        60        70        80        90

              160       170       180       190       200       210
pF1KB4 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL
              100       110       120       130       140       150

              220       230       240       250       260       270
pF1KB4 HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEP
              160       170       180       190       200       210

              280       290       300       310       320       330
pF1KB4 YDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLH
              220       230       240       250       260       270

              340       350       360       370       380       390
pF1KB4 KDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEA
              280       290       300       310       320       330

              400       410       420       
pF1KB4 VSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC
       :::::::::::::::::::::::::::::::::::::
NP_001 VSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC
              340       350       360       

>>NP_733794 (OMIM: 607589) serine/threonine-protein kina  (367 aa)
 initn: 2506 init1: 2506 opt: 2506  Z-score: 1153.1  bits: 222.2 E(85289): 1.7e-57
Smith-Waterman score: 2506; 100.0% identity (100.0% similar) in 367 aa overlap (61-427:1-367)

               40        50        60        70        80        90
pF1KB4 PWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNA
                                     ::::::::::::::::::::::::::::::
NP_733                               MNSSPAGTPSPQPSRANGNINLGPSANPNA
                                             10        20        30

              100       110       120       130       140       150
pF1KB4 QPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 QPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKN
               40        50        60        70        80        90

              160       170       180       190       200       210
pF1KB4 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL
              100       110       120       130       140       150

              220       230       240       250       260       270
pF1KB4 HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEP
              160       170       180       190       200       210

              280       290       300       310       320       330
pF1KB4 YDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 YDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLH
              220       230       240       250       260       270

              340       350       360       370       380       390
pF1KB4 KDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 KDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEA
              280       290       300       310       320       330

              400       410       420       
pF1KB4 VSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC
       :::::::::::::::::::::::::::::::::::::
NP_733 VSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC
              340       350       360       

>>NP_005618 (OMIM: 602958) serine/threonine-protein kina  (431 aa)
 initn: 1816 init1: 1712 opt: 1818  Z-score: 844.8  bits: 165.4 E(85289): 2.6e-40
Smith-Waterman score: 1818; 68.6% identity (88.4% similar) in 388 aa overlap (41-425:52-431)

               20        30        40        50        60        70
pF1KB4 PSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPS
                                     : .. .:    :. :.    ::..:  .: 
NP_005 AILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPEL---MNANP--SPP
              30        40        50        60           70        

               80        90       100       110       120       130
pF1KB4 PQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKS
       :.::.   .::::::.::.:.:.:: ::::::::..::::::..:.. .::::::::::.
NP_005 PSPSQ---QINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKA
         80           90       100       110       120       130   

              140       150       160       170       180       190
pF1KB4 ILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERR
       ::::::..:::.::.::::::.:::::::..:::: .::::::::.::::::.:::::: 
NP_005 ILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERC
           140       150       160       170       180       190   

              200       210       220       230       240       250
pF1KB4 FLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDT
       ::::::::::::.:::.::::::::.:::::::::::: :::.::::::::::..: ..:
NP_005 FLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNST
           200       210       220       230       240       250   

              260       270       280       290       300       310
pF1KB4 TSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQP
       ::::::::::::::::.:.::::.::::::::::::::.:::::::.....::.:::..:
NP_005 TSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKP
           260       270       280       290       300       310   

              320       330       340       350       360       370
pF1KB4 LQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFN
       ::.  . : .:  ::..::.::. .:::.: ::.:::.::::: :::::: .:..:::::
NP_005 LQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFN
           320       330       340       350       360       370   

              380       390       400          410       420       
pF1KB4 PNVTGPADLKHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSYAPEDDDILDC
       :::.:: ::.:::::::.: : .::: .::.:   :: . :. :::::::::  :..:  
NP_005 PNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL  
           380       390       400       410       420       430   

>>NP_001137150 (OMIM: 602958) serine/threonine-protein k  (445 aa)
 initn: 1816 init1: 1712 opt: 1818  Z-score: 844.6  bits: 165.4 E(85289): 2.6e-40
Smith-Waterman score: 1818; 68.6% identity (88.4% similar) in 388 aa overlap (41-425:66-445)

               20        30        40        50        60        70
pF1KB4 PSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPS
                                     : .. .:    :. :.    ::..:  .: 
NP_001 LSGLAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPEL---MNANP--SPP
          40        50        60        70        80             90

               80        90       100       110       120       130
pF1KB4 PQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKS
       :.::.   .::::::.::.:.:.:: ::::::::..::::::..:.. .::::::::::.
NP_001 PSPSQ---QINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKA
                 100       110       120       130       140       

              140       150       160       170       180       190
pF1KB4 ILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERR
       ::::::..:::.::.::::::.:::::::..:::: .::::::::.::::::.:::::: 
NP_001 ILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERC
       150       160       170       180       190       200       

              200       210       220       230       240       250
pF1KB4 FLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDT
       ::::::::::::.:::.::::::::.:::::::::::: :::.::::::::::..: ..:
NP_001 FLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNST
       210       220       230       240       250       260       

              260       270       280       290       300       310
pF1KB4 TSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQP
       ::::::::::::::::.:.::::.::::::::::::::.:::::::.....::.:::..:
NP_001 TSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKP
       270       280       290       300       310       320       

              320       330       340       350       360       370
pF1KB4 LQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFN
       ::.  . : .:  ::..::.::. .:::.: ::.:::.::::: :::::: .:..:::::
NP_001 LQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFN
       330       340       350       360       370       380       

              380       390       400          410       420       
pF1KB4 PNVTGPADLKHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSYAPEDDDILDC
       :::.:: ::.:::::::.: : .::: .::.:   :: . :. :::::::::  :..:  
NP_001 PNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL  
       390       400       410       420       430       440       

>>NP_001137149 (OMIM: 602958) serine/threonine-protein k  (459 aa)
 initn: 1816 init1: 1712 opt: 1818  Z-score: 844.5  bits: 165.4 E(85289): 2.7e-40
Smith-Waterman score: 1818; 68.6% identity (88.4% similar) in 388 aa overlap (41-425:80-459)

               20        30        40        50        60        70
pF1KB4 PSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPS
                                     : .. .:    :. :.    ::..:  .: 
NP_001 PPLKAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPEL---MNANP--SPP
      50        60        70        80        90          100      

               80        90       100       110       120       130
pF1KB4 PQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKS
       :.::.   .::::::.::.:.:.:: ::::::::..::::::..:.. .::::::::::.
NP_001 PSPSQ---QINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKA
             110       120       130       140       150       160 

              140       150       160       170       180       190
pF1KB4 ILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERR
       ::::::..:::.::.::::::.:::::::..:::: .::::::::.::::::.:::::: 
NP_001 ILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERC
             170       180       190       200       210       220 

              200       210       220       230       240       250
pF1KB4 FLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDT
       ::::::::::::.:::.::::::::.:::::::::::: :::.::::::::::..: ..:
NP_001 FLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNST
             230       240       250       260       270       280 

              260       270       280       290       300       310
pF1KB4 TSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQP
       ::::::::::::::::.:.::::.::::::::::::::.:::::::.....::.:::..:
NP_001 TSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKP
             290       300       310       320       330       340 

              320       330       340       350       360       370
pF1KB4 LQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFN
       ::.  . : .:  ::..::.::. .:::.: ::.:::.::::: :::::: .:..:::::
NP_001 LQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFN
             350       360       370       380       390       400 

              380       390       400          410       420       
pF1KB4 PNVTGPADLKHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSYAPEDDDILDC
       :::.:: ::.:::::::.: : .::: .::.:   :: . :. :::::::::  :..:  
NP_001 PNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL  
             410       420       430       440       450           

>>NP_001137148 (OMIM: 602958) serine/threonine-protein k  (526 aa)
 initn: 1840 init1: 1712 opt: 1818  Z-score: 844.0  bits: 165.5 E(85289): 2.8e-40
Smith-Waterman score: 1818; 68.6% identity (88.4% similar) in 388 aa overlap (41-425:147-526)

               20        30        40        50        60        70
pF1KB4 PSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPS
                                     : .. .:    :. :.    ::..:  .: 
NP_001 NDDPAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPEL---MNANP--SPP
        120       130       140       150       160            170 

               80        90       100       110       120       130
pF1KB4 PQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKS
       :.::.   .::::::.::.:.:.:: ::::::::..::::::..:.. .::::::::::.
NP_001 PSPSQ---QINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKA
                180       190       200       210       220        

              140       150       160       170       180       190
pF1KB4 ILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERR
       ::::::..:::.::.::::::.:::::::..:::: .::::::::.::::::.:::::: 
NP_001 ILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERC
      230       240       250       260       270       280        

              200       210       220       230       240       250
pF1KB4 FLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDT
       ::::::::::::.:::.::::::::.:::::::::::: :::.::::::::::..: ..:
NP_001 FLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNST
      290       300       310       320       330       340        

              260       270       280       290       300       310
pF1KB4 TSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQP
       ::::::::::::::::.:.::::.::::::::::::::.:::::::.....::.:::..:
NP_001 TSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKP
      350       360       370       380       390       400        

              320       330       340       350       360       370
pF1KB4 LQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFN
       ::.  . : .:  ::..::.::. .:::.: ::.:::.::::: :::::: .:..:::::
NP_001 LQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFN
      410       420       430       440       450       460        

              380       390       400          410       420       
pF1KB4 PNVTGPADLKHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSYAPEDDDILDC
       :::.:: ::.:::::::.: : .::: .::.:   :: . :. :::::::::  :..:  
NP_001 PNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL  
      470       480       490       500       510       520        

>>XP_011534373 (OMIM: 602958) PREDICTED: serine/threonin  (526 aa)
 initn: 1840 init1: 1712 opt: 1818  Z-score: 844.0  bits: 165.5 E(85289): 2.8e-40
Smith-Waterman score: 1818; 68.6% identity (88.4% similar) in 388 aa overlap (41-425:147-526)

               20        30        40        50        60        70
pF1KB4 PSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPS
                                     : .. .:    :. :.    ::..:  .: 
XP_011 NDDPAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPEL---MNANP--SPP
        120       130       140       150       160            170 

               80        90       100       110       120       130
pF1KB4 PQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKS
       :.::.   .::::::.::.:.:.:: ::::::::..::::::..:.. .::::::::::.
XP_011 PSPSQ---QINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKA
                180       190       200       210       220        

              140       150       160       170       180       190
pF1KB4 ILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERR
       ::::::..:::.::.::::::.:::::::..:::: .::::::::.::::::.:::::: 
XP_011 ILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERC
      230       240       250       260       270       280        

              200       210       220       230       240       250
pF1KB4 FLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDT
       ::::::::::::.:::.::::::::.:::::::::::: :::.::::::::::..: ..:
XP_011 FLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNST
      290       300       310       320       330       340        

              260       270       280       290       300       310
pF1KB4 TSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQP
       ::::::::::::::::.:.::::.::::::::::::::.:::::::.....::.:::..:
XP_011 TSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKP
      350       360       370       380       390       400        

              320       330       340       350       360       370
pF1KB4 LQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFN
       ::.  . : .:  ::..::.::. .:::.: ::.:::.::::: :::::: .:..:::::
XP_011 LQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFN
      410       420       430       440       450       460        

              380       390       400          410       420       
pF1KB4 PNVTGPADLKHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSYAPEDDDILDC
       :::.:: ::.:::::::.: : .::: .::.:   :: . :. :::::::::  :..:  
XP_011 PNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL  
      470       480       490       500       510       520        

>>NP_001028750 (OMIM: 607591) serine/threonine-protein k  (496 aa)
 initn: 1695 init1: 1632 opt: 1691  Z-score: 787.4  bits: 155.0 E(85289): 4e-37
Smith-Waterman score: 1691; 69.4% identity (88.9% similar) in 350 aa overlap (79-425:146-495)

       50        60        70        80        90       100        
pF1KB4 PVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGK
                                     :::::::.::.:.:::::::::::::..::
NP_001 FLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGK
         120       130       140       150       160       170     

      110       120       130       140       150       160        
pF1KB4 VLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEK
       ::::::: :: :::::::::: .:..:::.::::::.::::::.:::::::.::::: ::
NP_001 VLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEK
         180       190       200       210       220       230     

      170       180       190       200       210       220        
pF1KB4 LYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLD
       ::::::.:::::::::::::: : : ::::::::.:::.:::::..:.::::::::::::
NP_001 LYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLD
         240       250       260       270       280       290     

      230       240       250       260       270       280        
pF1KB4 CQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEML
         ::::::::::::::.   :::.:::::::::::::.::.::: .::::::::::::::
NP_001 SVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEML
         300       310       320       330       340       350     

      290       300       310       320       330       340        
pF1KB4 HGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKN
       .:::::: .::..::.::::.::..  : ...: ..:. ::.::...:::.: :::::.:
NP_001 YGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQN
         360       370       380       390       400       410     

      350       360       370       380       390       400        
pF1KB4 HVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPD-TVASSS-
       : ::  ..: :: .:.. :::::::.:: :...::  ::.:.:  :.  . : .....: 
NP_001 HPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASV
         420       430       440       450       460       470     

         410       420       
pF1KB4 -GASSAFLGFSYAPEDDDILDC
         :..::.:::::: ..:..  
NP_001 LEADDAFVGFSYAPPSEDLFL 
         480       490       

>>NP_037389 (OMIM: 607591) serine/threonine-protein kina  (496 aa)
 initn: 1695 init1: 1632 opt: 1691  Z-score: 787.4  bits: 155.0 E(85289): 4e-37
Smith-Waterman score: 1691; 69.4% identity (88.9% similar) in 350 aa overlap (79-425:146-495)

       50        60        70        80        90       100        
pF1KB4 PVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGK
                                     :::::::.::.:.:::::::::::::..::
NP_037 FLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGK
         120       130       140       150       160       170     

      110       120       130       140       150       160        
pF1KB4 VLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEK
       ::::::: :: :::::::::: .:..:::.::::::.::::::.:::::::.::::: ::
NP_037 VLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEK
         180       190       200       210       220       230     

      170       180       190       200       210       220        
pF1KB4 LYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLD
       ::::::.:::::::::::::: : : ::::::::.:::.:::::..:.::::::::::::
NP_037 LYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLD
         240       250       260       270       280       290     

      230       240       250       260       270       280        
pF1KB4 CQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEML
         ::::::::::::::.   :::.:::::::::::::.::.::: .::::::::::::::
NP_037 SVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEML
         300       310       320       330       340       350     

      290       300       310       320       330       340        
pF1KB4 HGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKN
       .:::::: .::..::.::::.::..  : ...: ..:. ::.::...:::.: :::::.:
NP_037 YGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQN
         360       370       380       390       400       410     

      350       360       370       380       390       400        
pF1KB4 HVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPD-TVASSS-
       : ::  ..: :: .:.. :::::::.:: :...::  ::.:.:  :.  . : .....: 
NP_037 HPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASV
         420       430       440       450       460       470     

         410       420       
pF1KB4 -GASSAFLGFSYAPEDDDILDC
         :..::.:::::: ..:..  
NP_037 LEADDAFVGFSYAPPSEDLFL 
         480       490       




427 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 15:03:05 2016 done: Thu Nov  3 15:03:06 2016
 Total Scan time:  9.340 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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