Result of FASTA (omim) for pF1KB3863
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3863, 801 aa
  1>>>pF1KB3863 801 - 801 aa - 801 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.9431+/-0.000373; mu= -7.6857+/- 0.023
 mean_var=376.7432+/-76.263, 0's: 0 Z-trim(125.2): 190  B-trim: 947 in 1/61
 Lambda= 0.066077
 statistics sampled from 48284 (48497) to 48284 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.822), E-opt: 0.2 (0.569), width:  16
 Scan time: 15.240

The best scores are:                                      opt bits E(85289)
NP_005095 (OMIM: 601540) bromodomain-containing pr ( 801) 5299 519.2 2.8e-146
NP_001106653 (OMIM: 601540) bromodomain-containing ( 801) 5299 519.2 2.8e-146
NP_001186385 (OMIM: 601540) bromodomain-containing ( 754) 4981 488.9 3.5e-137
NP_001278915 (OMIM: 601540) bromodomain-containing ( 681) 4462 439.4 2.5e-122
NP_001186384 (OMIM: 601540) bromodomain-containing ( 836) 4149 409.6 2.9e-113
XP_016870654 (OMIM: 601541) PREDICTED: bromodomain ( 725) 1971 201.9 8.1e-51
XP_006717354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 1971 201.9 8.1e-51
XP_011517354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 1971 201.9 8.1e-51
NP_031397 (OMIM: 601541) bromodomain-containing pr ( 726) 1971 201.9 8.1e-51
NP_055114 (OMIM: 608749) bromodomain-containing pr ( 722) 1101 119.0 7.5e-26
XP_011526158 (OMIM: 608749) PREDICTED: bromodomain ( 722) 1101 119.0 7.5e-26
NP_001317313 (OMIM: 608749) bromodomain-containing ( 794) 1101 119.0 8.1e-26
XP_011526156 (OMIM: 608749) PREDICTED: bromodomain (1362) 1101 119.2 1.2e-25
NP_490597 (OMIM: 608749) bromodomain-containing pr (1362) 1101 119.2 1.2e-25
XP_016870655 (OMIM: 601541) PREDICTED: bromodomain ( 405)  738 84.2 1.2e-15
NP_001229739 (OMIM: 602144) bromodomain testis-spe ( 874)  738 84.4 2.3e-15
NP_001229736 (OMIM: 602144) bromodomain testis-spe ( 901)  738 84.4 2.3e-15
NP_001229737 (OMIM: 602144) bromodomain testis-spe ( 901)  738 84.4 2.3e-15
NP_001229735 (OMIM: 602144) bromodomain testis-spe ( 951)  708 81.6 1.8e-14
NP_001229734 (OMIM: 602144) bromodomain testis-spe ( 947)  701 80.9 2.8e-14
XP_006710918 (OMIM: 602144) PREDICTED: bromodomain ( 947)  701 80.9 2.8e-14
XP_006710920 (OMIM: 602144) PREDICTED: bromodomain ( 947)  701 80.9 2.8e-14
XP_011540335 (OMIM: 602144) PREDICTED: bromodomain ( 947)  701 80.9 2.8e-14
XP_006710916 (OMIM: 602144) PREDICTED: bromodomain ( 947)  701 80.9 2.8e-14
XP_011540334 (OMIM: 602144) PREDICTED: bromodomain ( 947)  701 80.9 2.8e-14
XP_006710919 (OMIM: 602144) PREDICTED: bromodomain ( 947)  701 80.9 2.8e-14
NP_997072 (OMIM: 602144) bromodomain testis-specif ( 947)  701 80.9 2.8e-14
XP_006710917 (OMIM: 602144) PREDICTED: bromodomain ( 947)  701 80.9 2.8e-14
NP_001717 (OMIM: 602144) bromodomain testis-specif ( 947)  701 80.9 2.8e-14
XP_011540338 (OMIM: 602144) PREDICTED: bromodomain ( 947)  701 80.9 2.8e-14
XP_011540336 (OMIM: 602144) PREDICTED: bromodomain ( 947)  701 80.9 2.8e-14
XP_011540337 (OMIM: 602144) PREDICTED: bromodomain ( 947)  701 80.9 2.8e-14


>>NP_005095 (OMIM: 601540) bromodomain-containing protei  (801 aa)
 initn: 5299 init1: 5299 opt: 5299  Z-score: 2747.3  bits: 519.2 E(85289): 2.8e-146
Smith-Waterman score: 5299; 100.0% identity (100.0% similar) in 801 aa overlap (1-801:1-801)

               10        20        30        40        50        60
pF1KB3 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
              730       740       750       760       770       780

              790       800 
pF1KB3 SDSSSSSSSSSSSDTSDSDSG
       :::::::::::::::::::::
NP_005 SDSSSSSSSSSSSDTSDSDSG
              790       800 

>>NP_001106653 (OMIM: 601540) bromodomain-containing pro  (801 aa)
 initn: 5299 init1: 5299 opt: 5299  Z-score: 2747.3  bits: 519.2 E(85289): 2.8e-146
Smith-Waterman score: 5299; 100.0% identity (100.0% similar) in 801 aa overlap (1-801:1-801)

               10        20        30        40        50        60
pF1KB3 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
              730       740       750       760       770       780

              790       800 
pF1KB3 SDSSSSSSSSSSSDTSDSDSG
       :::::::::::::::::::::
NP_001 SDSSSSSSSSSSSDTSDSDSG
              790       800 

>>NP_001186385 (OMIM: 601540) bromodomain-containing pro  (754 aa)
 initn: 4981 init1: 4981 opt: 4981  Z-score: 2583.8  bits: 488.9 E(85289): 3.5e-137
Smith-Waterman score: 4981; 100.0% identity (100.0% similar) in 754 aa overlap (48-801:1-754)

        20        30        40        50        60        70       
pF1KB3 GLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTN
                                     ::::::::::::::::::::::::::::::
NP_001                               MASVPALQLTPANPPPPEVSNPKKPGRVTN
                                             10        20        30

        80        90       100       110       120       130       
pF1KB3 QLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWA
               40        50        60        70        80        90

       140       150       160       170       180       190       
pF1KB3 ASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHK
              100       110       120       130       140       150

       200       210       220       230       240       250       
pF1KB3 KGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSA
              160       170       180       190       200       210

       260       270       280       290       300       310       
pF1KB3 GPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMR
              220       230       240       250       260       270

       320       330       340       350       360       370       
pF1KB3 RESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVD
              280       290       300       310       320       330

       380       390       400       410       420       430       
pF1KB3 ASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVA
              340       350       360       370       380       390

       440       450       460       470       480       490       
pF1KB3 MARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEE
              400       410       420       430       440       450

       500       510       520       530       540       550       
pF1KB3 DEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKK
              460       470       480       490       500       510

       560       570       580       590       600       610       
pF1KB3 RKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPK
              520       530       540       550       560       570

       620       630       640       650       660       670       
pF1KB3 KATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLR
              580       590       600       610       620       630

       680       690       700       710       720       730       
pF1KB3 DSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELE
              640       650       660       670       680       690

       740       750       760       770       780       790       
pF1KB3 KRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSD
              700       710       720       730       740       750

       800 
pF1KB3 SDSG
       ::::
NP_001 SDSG
           

>>NP_001278915 (OMIM: 601540) bromodomain-containing pro  (681 aa)
 initn: 4462 init1: 4462 opt: 4462  Z-score: 2317.1  bits: 439.4 E(85289): 2.5e-122
Smith-Waterman score: 4462; 100.0% identity (100.0% similar) in 681 aa overlap (121-801:1-681)

              100       110       120       130       140       150
pF1KB3 WKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFT
                                     ::::::::::::::::::::::::::::::
NP_001                               MDMGTIKRRLENNYYWAASECMQDFNTMFT
                                             10        20        30

              160       170       180       190       200       210
pF1KB3 NCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVT
               40        50        60        70        80        90

              220       230       240       250       260       270
pF1KB3 SAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPA
              100       110       120       130       140       150

              280       290       300       310       320       330
pF1KB3 QPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKD
              160       170       180       190       200       210

              340       350       360       370       380       390
pF1KB3 LPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDII
              220       230       240       250       260       270

              400       410       420       430       440       450
pF1KB3 KHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRY
              280       290       300       310       320       330

              460       470       480       490       500       510
pF1KB3 AKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESS
              340       350       360       370       380       390

              520       530       540       550       560       570
pF1KB3 DSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGAD
              400       410       420       430       440       450

              580       590       600       610       620       630
pF1KB3 EDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTG
              460       470       480       490       500       510

              640       650       660       670       680       690
pF1KB3 YDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFET
              520       530       540       550       560       570

              700       710       720       730       740       750
pF1KB3 LKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNST
              580       590       600       610       620       630

              760       770       780       790       800 
pF1KB3 KKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
       :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
              640       650       660       670       680 

>>NP_001186384 (OMIM: 601540) bromodomain-containing pro  (836 aa)
 initn: 4134 init1: 4134 opt: 4149  Z-score: 2154.5  bits: 409.6 E(85289): 2.9e-113
Smith-Waterman score: 5198; 95.8% identity (95.8% similar) in 833 aa overlap (1-798:1-833)

               10        20        30        40        50        60
pF1KB3 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
              550       560       570       580       590       600

              610                                          620     
pF1KB3 GPSGFGPSGGSGTKL-----------------------------------PKKATKTAPP
       :::::::::::::::                                   ::::::::::
NP_001 GPSGFGPSGGSGTKLQAGVQWRDLGLLQPPLLGFKRFSCLSLPSSQDYRLPKKATKTAPP
              610       620       630       640       650       660

         630       640       650       660       670       680     
pF1KB3 ALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIE
              670       680       690       700       710       720

         690       700       710       720       730       740     
pF1KB3 IDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSG
              730       740       750       760       770       780

         750       760       770       780       790       800 
pF1KB3 QLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
       :::::::::::::::::::::::::::::::::::::::::::::::::::::   
NP_001 QLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
              790       800       810       820       830      

>>XP_016870654 (OMIM: 601541) PREDICTED: bromodomain-con  (725 aa)
 initn: 2657 init1: 961 opt: 1971  Z-score: 1033.3  bits: 201.9 E(85289): 8.1e-51
Smith-Waterman score: 2918; 63.6% identity (79.6% similar) in 763 aa overlap (49-799:10-725)

       20        30        40        50        60        70        
pF1KB3 LLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQ
                                     :..::    :.::::::::::.:::: :::
XP_016                      MSTATTVAPAGIPATP-GPVNPPPPEVSNPSKPGRKTNQ
                                    10         20        30        

       80        90       100       110       120       130        
pF1KB3 LQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAA
       :::...::.:.:::::::::: :::::.::.:::::::::.::::::::.::::::::.:
XP_016 LQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSA
       40        50        60        70        80        90        

      140       150       160       170       180       190        
pF1KB3 SECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKK
       :::::::::::::::::::::::::::::.::::::::::.::::: ::.   ::.. .:
XP_016 SECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRK
      100       110       120       130       140       150        

      200       210       220        230         240           250 
pF1KB3 GAKLAALQGSVTSAHQVPAVSSVSH-TALYTPPPEIPTT--VLNIPHPS----VISSPLL
        :  :   :.    .:: ::::::  : . . :: .  :  .   : :.    : : :. 
XP_016 PAAGAQSAGT----QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVP
      160           170       180       190       200       210    

             260       270       280       290       300       310 
pF1KB3 KSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAA
        .     :    : ..::. :..::::::::::::::: .:: :  : . :: : .:: :
XP_016 PAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLS-DPKQA
          220       230       240       250       260        270   

             320       330       340       350       360       370 
pF1KB3 RLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWP
       ..   :. .:::::::.::: :..  ....:::::::.:..:..::.:.:::::::::::
XP_016 KVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWP
           280       290       300       310       320       330   

             380       390       400       410       420       430 
pF1KB3 FYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP
       ::::::: :: :::::::::::::::::::::..:.: ::: ::::::::::::::::::
XP_016 FYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPP
           340       350       360       370       380       390   

             440       450       460       470       480        490
pF1KB3 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES-SSEESSSESS
       ::.:::::::::::::.:.:::::::.:   ::. .:  : ..:..  : :::::::.:.
XP_016 DHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAA--PMVSKGAESSRSSEESSSDSG
           400       410       420       430         440       450 

              500       510       520       530       540       550
pF1KB3 SEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKRE
       :                  :::::::: :::::::::.:::::::::::.:..:::.:.:
XP_016 S------------------SDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKE
                               460       470       480       490   

                 560       570       580       590       600       
pF1KB3 KKEKKKKRK---AEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGP
       ::::.::.:    ::.. .. :.:. :.  :: : .  ..::: .. ..:..        
XP_016 KKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAP-PAKQAQQKKAPAKKANSTTT-------
           500       510       520        530       540            

       610       620       630       640       650       660       
pF1KB3 SGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVH
          .: .: ::. : :     ..::::::::. :::::::::::::::.:::::::::::
XP_016 ---AGRQL-KKGGKQAS----ASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVH
            550            560       570       580       590       

       670       680       690       700       710        720      
pF1KB3 IIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTI-KKPVGKTKE
       :::.::::::::::.:::::::::::.::::::::: :::.:: :::..  :: ..:.::
XP_016 IIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSSGKKQAAKSKE
       600       610       620       630       640       650       

        730       740       750       760       770       780      
pF1KB3 ELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSS
       ::: :::.:::::::::::::.:.::: .:  ::   .:: . . :::: :::::.:.::
XP_016 ELAQEKKKELEKRLQDVSGQLSSSKKPARK--EKP--GSAPSGGPSRLS-SSSSSESGSS
       660       670       680         690         700        710  

        790       800 
pF1KB3 SSSSSSSDTSDSDSG
       :::.::::.:::.  
XP_016 SSSGSSSDSSDSE  
            720       

>>XP_006717354 (OMIM: 601541) PREDICTED: bromodomain-con  (726 aa)
 initn: 2503 init1: 961 opt: 1971  Z-score: 1033.3  bits: 201.9 E(85289): 8.1e-51
Smith-Waterman score: 2918; 63.5% identity (79.5% similar) in 764 aa overlap (49-799:10-726)

       20        30        40        50        60        70        
pF1KB3 LLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQ
                                     :..::    :.::::::::::.:::: :::
XP_006                      MSTATTVAPAGIPATP-GPVNPPPPEVSNPSKPGRKTNQ
                                    10         20        30        

       80        90       100       110       120       130        
pF1KB3 LQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAA
       :::...::.:.:::::::::: :::::.::.:::::::::.::::::::.::::::::.:
XP_006 LQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSA
       40        50        60        70        80        90        

      140       150       160       170       180       190        
pF1KB3 SECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKK
       :::::::::::::::::::::::::::::.::::::::::.::::: ::.   ::.. .:
XP_006 SECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRK
      100       110       120       130       140       150        

      200       210       220        230         240           250 
pF1KB3 GAKLAALQGSVTSAHQVPAVSSVSH-TALYTPPPEIPTT--VLNIPHPS----VISSPLL
        :  :   :.    .:: ::::::  : . . :: .  :  .   : :.    : : :. 
XP_006 PAAGAQSAGT----QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVP
      160           170       180       190       200       210    

             260       270       280       290       300       310 
pF1KB3 KSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAA
        .     :    : ..::. :..::::::::::::::: .:: :  : . :: : .:: :
XP_006 PAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLS-DPKQA
          220       230       240       250       260        270   

             320       330       340       350       360       370 
pF1KB3 RLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWP
       ..   :. .:::::::.::: :..  ....:::::::.:..:..::.:.:::::::::::
XP_006 KVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWP
           280       290       300       310       320       330   

             380       390       400       410       420       430 
pF1KB3 FYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP
       ::::::: :: :::::::::::::::::::::..:.: ::: ::::::::::::::::::
XP_006 FYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPP
           340       350       360       370       380       390   

             440       450       460       470       480        490
pF1KB3 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES-SSEESSSESS
       ::.:::::::::::::.:.:::::::.:   ::. .:  : ..:..  : :::::::.:.
XP_006 DHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAA--PMVSKGAESSRSSEESSSDSG
           400       410       420       430         440       450 

              500       510       520       530       540       550
pF1KB3 SEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKRE
       :                  :::::::: :::::::::.:::::::::::.:..:::.:.:
XP_006 S------------------SDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKE
                               460       470       480       490   

                 560       570       580       590       600       
pF1KB3 KKEKKKKRK---AEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGP
       ::::.::.:    ::.. .. :.:. :.  :: : .  ..::: .. ..:..        
XP_006 KKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAP-PAKQAQQKKAPAKKANSTTT-------
           500       510       520        530       540            

       610       620       630       640       650       660       
pF1KB3 SGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVH
          .: .: ::. : :     ..::::::::. :::::::::::::::.:::::::::::
XP_006 ---AGRQL-KKGGKQAS----ASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVH
            550            560       570       580       590       

       670       680       690       700       710         720     
pF1KB3 IIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTI--KKPVGKTK
       :::.::::::::::.:::::::::::.::::::::: :::.:: :::..   :: ..:.:
XP_006 IIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSK
       600       610       620       630       640       650       

         730       740       750       760       770       780     
pF1KB3 EELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSS
       :::: :::.:::::::::::::.:.::: .:  ::   .:: . . :::: :::::.:.:
XP_006 EELAQEKKKELEKRLQDVSGQLSSSKKPARK--EKP--GSAPSGGPSRLS-SSSSSESGS
       660       670       680         690         700        710  

         790       800 
pF1KB3 SSSSSSSSDTSDSDSG
       ::::.::::.:::.  
XP_006 SSSSGSSSDSSDSE  
            720        

>>XP_011517354 (OMIM: 601541) PREDICTED: bromodomain-con  (726 aa)
 initn: 2503 init1: 961 opt: 1971  Z-score: 1033.3  bits: 201.9 E(85289): 8.1e-51
Smith-Waterman score: 2918; 63.5% identity (79.5% similar) in 764 aa overlap (49-799:10-726)

       20        30        40        50        60        70        
pF1KB3 LLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQ
                                     :..::    :.::::::::::.:::: :::
XP_011                      MSTATTVAPAGIPATP-GPVNPPPPEVSNPSKPGRKTNQ
                                    10         20        30        

       80        90       100       110       120       130        
pF1KB3 LQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAA
       :::...::.:.:::::::::: :::::.::.:::::::::.::::::::.::::::::.:
XP_011 LQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSA
       40        50        60        70        80        90        

      140       150       160       170       180       190        
pF1KB3 SECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKK
       :::::::::::::::::::::::::::::.::::::::::.::::: ::.   ::.. .:
XP_011 SECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRK
      100       110       120       130       140       150        

      200       210       220        230         240           250 
pF1KB3 GAKLAALQGSVTSAHQVPAVSSVSH-TALYTPPPEIPTT--VLNIPHPS----VISSPLL
        :  :   :.    .:: ::::::  : . . :: .  :  .   : :.    : : :. 
XP_011 PAAGAQSAGT----QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVP
      160           170       180       190       200       210    

             260       270       280       290       300       310 
pF1KB3 KSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAA
        .     :    : ..::. :..::::::::::::::: .:: :  : . :: : .:: :
XP_011 PAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLS-DPKQA
          220       230       240       250       260        270   

             320       330       340       350       360       370 
pF1KB3 RLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWP
       ..   :. .:::::::.::: :..  ....:::::::.:..:..::.:.:::::::::::
XP_011 KVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWP
           280       290       300       310       320       330   

             380       390       400       410       420       430 
pF1KB3 FYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP
       ::::::: :: :::::::::::::::::::::..:.: ::: ::::::::::::::::::
XP_011 FYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPP
           340       350       360       370       380       390   

             440       450       460       470       480        490
pF1KB3 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES-SSEESSSESS
       ::.:::::::::::::.:.:::::::.:   ::. .:  : ..:..  : :::::::.:.
XP_011 DHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAA--PMVSKGAESSRSSEESSSDSG
           400       410       420       430         440       450 

              500       510       520       530       540       550
pF1KB3 SEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKRE
       :                  :::::::: :::::::::.:::::::::::.:..:::.:.:
XP_011 S------------------SDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKE
                               460       470       480       490   

                 560       570       580       590       600       
pF1KB3 KKEKKKKRK---AEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGP
       ::::.::.:    ::.. .. :.:. :.  :: : .  ..::: .. ..:..        
XP_011 KKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAP-PAKQAQQKKAPAKKANSTTT-------
           500       510       520        530       540            

       610       620       630       640       650       660       
pF1KB3 SGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVH
          .: .: ::. : :     ..::::::::. :::::::::::::::.:::::::::::
XP_011 ---AGRQL-KKGGKQAS----ASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVH
            550            560       570       580       590       

       670       680       690       700       710         720     
pF1KB3 IIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTI--KKPVGKTK
       :::.::::::::::.:::::::::::.::::::::: :::.:: :::..   :: ..:.:
XP_011 IIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSK
       600       610       620       630       640       650       

         730       740       750       760       770       780     
pF1KB3 EELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSS
       :::: :::.:::::::::::::.:.::: .:  ::   .:: . . :::: :::::.:.:
XP_011 EELAQEKKKELEKRLQDVSGQLSSSKKPARK--EKP--GSAPSGGPSRLS-SSSSSESGS
       660       670       680         690         700        710  

         790       800 
pF1KB3 SSSSSSSSDTSDSDSG
       ::::.::::.:::.  
XP_011 SSSSGSSSDSSDSE  
            720        

>>NP_031397 (OMIM: 601541) bromodomain-containing protei  (726 aa)
 initn: 2503 init1: 961 opt: 1971  Z-score: 1033.3  bits: 201.9 E(85289): 8.1e-51
Smith-Waterman score: 2918; 63.5% identity (79.5% similar) in 764 aa overlap (49-799:10-726)

       20        30        40        50        60        70        
pF1KB3 LLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQ
                                     :..::    :.::::::::::.:::: :::
NP_031                      MSTATTVAPAGIPATP-GPVNPPPPEVSNPSKPGRKTNQ
                                    10         20        30        

       80        90       100       110       120       130        
pF1KB3 LQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAA
       :::...::.:.:::::::::: :::::.::.:::::::::.::::::::.::::::::.:
NP_031 LQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSA
       40        50        60        70        80        90        

      140       150       160       170       180       190        
pF1KB3 SECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKK
       :::::::::::::::::::::::::::::.::::::::::.::::: ::.   ::.. .:
NP_031 SECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRK
      100       110       120       130       140       150        

      200       210       220        230         240           250 
pF1KB3 GAKLAALQGSVTSAHQVPAVSSVSH-TALYTPPPEIPTT--VLNIPHPS----VISSPLL
        :  :   :.    .:: ::::::  : . . :: .  :  .   : :.    : : :. 
NP_031 PAAGAQSAGT----QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVP
      160           170       180       190       200       210    

             260       270       280       290       300       310 
pF1KB3 KSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAA
        .     :    : ..::. :..::::::::::::::: .:: :  : . :: : .:: :
NP_031 PAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLS-DPKQA
          220       230       240       250       260        270   

             320       330       340       350       360       370 
pF1KB3 RLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWP
       ..   :. .:::::::.::: :..  ....:::::::.:..:..::.:.:::::::::::
NP_031 KVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWP
           280       290       300       310       320       330   

             380       390       400       410       420       430 
pF1KB3 FYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP
       ::::::: :: :::::::::::::::::::::..:.: ::: ::::::::::::::::::
NP_031 FYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPP
           340       350       360       370       380       390   

             440       450       460       470       480        490
pF1KB3 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES-SSEESSSESS
       ::.:::::::::::::.:.:::::::.:   ::. .:  : ..:..  : :::::::.:.
NP_031 DHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAA--PMVSKGAESSRSSEESSSDSG
           400       410       420       430         440       450 

              500       510       520       530       540       550
pF1KB3 SEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKRE
       :                  :::::::: :::::::::.:::::::::::.:..:::.:.:
NP_031 S------------------SDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKE
                               460       470       480       490   

                 560       570       580       590       600       
pF1KB3 KKEKKKKRK---AEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGP
       ::::.::.:    ::.. .. :.:. :.  :: : .  ..::: .. ..:..        
NP_031 KKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAP-PAKQAQQKKAPAKKANSTTT-------
           500       510       520        530       540            

       610       620       630       640       650       660       
pF1KB3 SGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVH
          .: .: ::. : :     ..::::::::. :::::::::::::::.:::::::::::
NP_031 ---AGRQL-KKGGKQAS----ASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVH
            550            560       570       580       590       

       670       680       690       700       710         720     
pF1KB3 IIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTI--KKPVGKTK
       :::.::::::::::.:::::::::::.::::::::: :::.:: :::..   :: ..:.:
NP_031 IIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSK
       600       610       620       630       640       650       

         730       740       750       760       770       780     
pF1KB3 EELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSS
       :::: :::.:::::::::::::.:.::: .:  ::   .:: . . :::: :::::.:.:
NP_031 EELAQEKKKELEKRLQDVSGQLSSSKKPARK--EKP--GSAPSGGPSRLS-SSSSSESGS
       660       670       680         690         700        710  

         790       800 
pF1KB3 SSSSSSSSDTSDSDSG
       ::::.::::.:::.  
NP_031 SSSSGSSSDSSDSE  
            720        

>>NP_055114 (OMIM: 608749) bromodomain-containing protei  (722 aa)
 initn: 2481 init1: 898 opt: 1101  Z-score: 585.1  bits: 119.0 E(85289): 7.5e-26
Smith-Waterman score: 2486; 54.8% identity (72.9% similar) in 764 aa overlap (27-754:5-721)

               10        20        30        40        50          
pF1KB3 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPAL-QLTPA
                                 ..:: :.:.  .. .:.:.  :... :  :  ::
NP_055                       MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPA
                                     10        20        30        

      60             70        80        90       100       110    
pF1KB3 N-----PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYH
       :     :::::.:::.:: : ::::::: .::.:.::::::::::.::::::::.::::.
NP_055 NAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYY
       40        50        60        70        80        90        

          120       130       140       150       160       170    
pF1KB3 KIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFL
       :::: ::::::::.:::::::: :.::.:::::::::::::::: :::::::..:::.::
NP_055 KIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFL
      100       110       120       130       140       150        

          180       190       200       210       220       230    
pF1KB3 QKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIP
       ::.  .: :: :....  :.  .   . .. . .:... ..  .:.  .:   :: :. :
NP_055 QKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQ--TPQPN-P
      160       170       180       190       200         210      

          240              250           260       270             
pF1KB3 TTVLNIPHPS-------VISSPLLKSLH----SAGPPLLAVTAAPPA-------------
         :   :::        ....:..  .     .. ::.      :::             
NP_055 PPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPII
         220       230       240       250       260       270     

                  280       290        300       310       320     
pF1KB3 ----QPLAKKKGVKRKADTTTPTPT-AILAPGSPASPPGSLEPKAARLPPMRRESGRPIK
           ::.  ::::::::::::::    :  :  :. ::   :::...:  .::::.::.:
NP_055 AATPQPVKTKKGVKRKADTTTPTTIDPIHEP--PSLPP---EPKTTKLG-QRRESSRPVK
         280       290       300         310           320         

         330       340       350       360       370       380     
pF1KB3 PPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHD
       ::.::.:::::.    :..:.::::: :.:::::...:::::::::::::::. ::::::
NP_055 PPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHD
     330       340       350       360       370       380         

         390       400       410       420       430       440     
pF1KB3 YHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDV
       : ::::::::.::.: :.: :.:::::::.::::::::::::::::::.:::::::::::
NP_055 YCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDV
     390       400       410       420       430       440         

         450       460       470       480       490       500     
pF1KB3 FEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEE
       ::.:.::::::: ::     : :.::  .:  .  :: .:::.:::            . 
NP_055 FEMRFAKMPDEPEEPVVAVSSPAVPPP-TKVVAPPSSSDSSSDSSS------------DS
     450       460       470        480       490                  

         510       520       530       540        550       560    
pF1KB3 ESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRK-REKKEKKKKRKAEKHR
       .: ..:::::::.:::::::::.:::::::::::   .:::.: ..::::::    :::.
NP_055 DSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKK----EKHK
        500       510       520       530       540           550  

          570       580       590       600       610       620    
pF1KB3 GRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAP
        :    :..:  .: .:: :::.:: ..:... .   :.   :             :. :
NP_055 -RKEEVEENKKSKAKEPP-PKKTKKNNSSNSNVSKKEPA---P------------MKSKP
             560        570       580          590                 

          630       640       650       660       670       680    
pF1KB3 PALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEI
       :  :: :.::::.. .::::.:::::::::::::::::::::::::.:::::..:::.::
NP_055 P--PT-YESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEI
            600       610       620       630       640       650  

          690       700       710       720       730       740    
pF1KB3 EIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVS
       ::::::::::::::::::: :::::: ::: . :  :   . ..   .. : :.  .. :
NP_055 EIDFETLKPSTLRELERYVTSCLRKK-RKPQAEKVDVIAGSSKMKGFSSSESESSSESSS
            660       670        680       690       700       710 

          750       760       770       780       790       800 
pF1KB3 GQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
       .. ....  :                                               
NP_055 SDSEDSETGPA                                              
             720                                                




801 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 14:05:30 2016 done: Thu Nov  3 14:05:32 2016
 Total Scan time: 15.240 Total Display time:  0.240

Function used was FASTA [36.3.4 Apr, 2011]
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