Result of FASTA (omim) for pF1KB3493
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3493, 630 aa
  1>>>pF1KB3493 630 - 630 aa - 630 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.1340+/-0.000399; mu= 8.5315+/- 0.025
 mean_var=226.2065+/-47.007, 0's: 0 Z-trim(120.2): 236  B-trim: 1892 in 1/57
 Lambda= 0.085275
 statistics sampled from 34884 (35161) to 34884 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.742), E-opt: 0.2 (0.412), width:  16
 Scan time: 11.480

The best scores are:                                      opt bits E(85289)
NP_005073 (OMIM: 600453) E3 ubiquitin/ISG15 ligase ( 630) 4285 540.4 7.3e-153
NP_036233 (OMIM: 610658) tripartite motif-containi ( 588)  424 65.3 6.8e-10
XP_011541034 (OMIM: 610658) PREDICTED: tripartite  ( 621)  424 65.4   7e-10
XP_011541031 (OMIM: 610658) PREDICTED: tripartite  ( 622)  424 65.4   7e-10
NP_006461 (OMIM: 609505) tripartite motif-containi ( 564)  394 61.6 8.5e-09
XP_006717401 (OMIM: 606556) PREDICTED: tripartite  ( 392)  321 52.5 3.3e-06
XP_011517546 (OMIM: 606556) PREDICTED: tripartite  ( 285)  315 51.6 4.4e-06
XP_016870841 (OMIM: 606556) PREDICTED: tripartite  ( 442)  317 52.1 5.1e-06
NP_150088 (OMIM: 606556) tripartite motif-containi ( 442)  317 52.1 5.1e-06
XP_016870842 (OMIM: 606556) PREDICTED: tripartite  ( 442)  317 52.1 5.1e-06
NP_055603 (OMIM: 606556) tripartite motif-containi ( 442)  317 52.1 5.1e-06
XP_005252377 (OMIM: 606556) PREDICTED: tripartite  ( 442)  317 52.1 5.1e-06
XP_005258100 (OMIM: 611358,614192) PREDICTED: E3 u ( 251)  305 50.3 9.6e-06
XP_016880712 (OMIM: 611358,614192) PREDICTED: E3 u ( 251)  305 50.3 9.6e-06
NP_001332879 (OMIM: 606125) probable E3 ubiquitin- ( 519)  309 51.1 1.1e-05
NP_258411 (OMIM: 611041) tripartite motif-containi ( 638)  309 51.2 1.3e-05
NP_115698 (OMIM: 611358,614192) E3 ubiquitin-prote ( 432)  305 50.6 1.4e-05
NP_112174 (OMIM: 606125) probable E3 ubiquitin-pro ( 551)  306 50.8 1.5e-05
XP_011517383 (OMIM: 609829) PREDICTED: FSD1-like p ( 311)  287 48.2 5.1e-05
XP_011517382 (OMIM: 609829) PREDICTED: FSD1-like p ( 322)  287 48.2 5.3e-05
XP_016870675 (OMIM: 609829) PREDICTED: FSD1-like p ( 322)  287 48.2 5.3e-05
NP_001274121 (OMIM: 609829) FSD1-like protein isof ( 497)  290 48.8 5.5e-05
XP_016870671 (OMIM: 609829) PREDICTED: FSD1-like p ( 529)  290 48.8 5.8e-05
XP_011517381 (OMIM: 609829) PREDICTED: FSD1-like p ( 542)  290 48.8 5.9e-05
XP_005252317 (OMIM: 609829) PREDICTED: FSD1-like p ( 384)  287 48.3   6e-05
XP_016870673 (OMIM: 609829) PREDICTED: FSD1-like p ( 384)  287 48.3   6e-05
XP_016870672 (OMIM: 609829) PREDICTED: FSD1-like p ( 498)  287 48.4 7.1e-05
NP_001274120 (OMIM: 609829) FSD1-like protein isof ( 508)  287 48.4 7.2e-05
NP_001317668 (OMIM: 609829) FSD1-like protein isof ( 509)  287 48.4 7.2e-05
NP_001138785 (OMIM: 609829) FSD1-like protein isof ( 530)  287 48.4 7.4e-05
XP_005252311 (OMIM: 609829) PREDICTED: FSD1-like p ( 541)  287 48.5 7.6e-05
XP_011517380 (OMIM: 609829) PREDICTED: FSD1-like p ( 543)  287 48.5 7.6e-05
XP_011517379 (OMIM: 609829) PREDICTED: FSD1-like p ( 547)  287 48.5 7.6e-05
NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488)  285 48.2 8.3e-05
XP_011512533 (OMIM: 613591) PREDICTED: butyrophili ( 313)  278 47.1 0.00011
NP_001184168 (OMIM: 613591) butyrophilin subfamily ( 313)  278 47.1 0.00011
NP_976039 (OMIM: 609315) tripartite motif-containi ( 303)  276 46.8 0.00013
NP_976040 (OMIM: 609315) tripartite motif-containi ( 303)  276 46.8 0.00013
XP_016865392 (OMIM: 609315) PREDICTED: tripartite  ( 303)  276 46.8 0.00013
NP_976041 (OMIM: 609315) tripartite motif-containi ( 303)  276 46.8 0.00013
XP_005248855 (OMIM: 613591) PREDICTED: butyrophili ( 407)  278 47.2 0.00013
XP_016865656 (OMIM: 613591) PREDICTED: butyrophili ( 407)  278 47.2 0.00013
NP_853509 (OMIM: 613591) butyrophilin subfamily 2  ( 407)  278 47.2 0.00013
NP_976042 (OMIM: 609315) tripartite motif-containi ( 329)  276 46.9 0.00014
XP_011512531 (OMIM: 613591) PREDICTED: butyrophili ( 461)  278 47.3 0.00015
XP_016865655 (OMIM: 613591) PREDICTED: butyrophili ( 461)  278 47.3 0.00015
XP_005248854 (OMIM: 613591) PREDICTED: butyrophili ( 523)  278 47.3 0.00016
XP_006715016 (OMIM: 613591) PREDICTED: butyrophili ( 523)  278 47.3 0.00016
NP_008926 (OMIM: 613591) butyrophilin subfamily 2  ( 523)  278 47.3 0.00016
XP_011512530 (OMIM: 613591) PREDICTED: butyrophili ( 523)  278 47.3 0.00016


>>NP_005073 (OMIM: 600453) E3 ubiquitin/ISG15 ligase TRI  (630 aa)
 initn: 4285 init1: 4285 opt: 4285  Z-score: 2865.4  bits: 540.4 E(85289): 7.3e-153
Smith-Waterman score: 4285; 99.5% identity (99.7% similar) in 630 aa overlap (1-630:1-630)

               10        20        30        40        50        60
pF1KB3 MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQAR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 PQLHKNTVLCNVVEQFLQADLAREPPADGWTPPARASAPSPNAQVACDHCLKEAAVKTCL
       :::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
NP_005 PQLHKNTVLCNVVEQFLQADLAREPPADVWTPPARASAPSPNAQVACDHCLKEAAVKTCL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 VCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 VEHKACSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQ
       ::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQ
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 LQQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LQQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLT
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 KRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQELTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
NP_005 KRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 EAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYNTAHNKVALSECYTVAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYNTAHNKVALSECYTVAS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 VAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCGVGICYGSMNRQGPES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCGVGICYGSMNRQGPES
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 RLGRNSASWCVEWFNTKISAWHNNVEKTLPSTKATRVGVLLNCDHGFVIFFAVADKVHLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RLGRNSASWCVEWFNTKISAWHNNVEKTLPSTKATRVGVLLNCDHGFVIFFAVADKVHLM
              550       560       570       580       590       600

              610       620       630
pF1KB3 YKFRVDFTEALYPAFWVFSAGATLSICSPK
       ::::::::::::::::::::::::::::::
NP_005 YKFRVDFTEALYPAFWVFSAGATLSICSPK
              610       620       630

>>NP_036233 (OMIM: 610658) tripartite motif-containing p  (588 aa)
 initn: 296 init1: 296 opt: 424  Z-score: 298.7  bits: 65.3 E(85289): 6.8e-10
Smith-Waterman score: 424; 28.7% identity (62.7% similar) in 268 aa overlap (100-358:166-427)

      70        80        90       100       110         120       
pF1KB3 CNVVEQFLQADLAREPPADGWTPPARASAPSPNAQVACDHCL--KEAAVKTCLVCMASFC
                                     : . .: :: :.  :. :::.::::.::::
NP_036 RKPTVSIMEPGETRRNSYPRADTGLFSRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFC
         140       150       160       170       180       190     

       130       140       150       160       170       180       
pF1KB3 QEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICLV-EHKAC
       . ::.::... ::.:: :  :.::.  :::  :..  :.::   . :::..:.  :::  
NP_036 ELHLKPHLEGAAFRDHQLLEPIRDFEARKCPVHGKTMELFCQTDQTCICYLCMFQEHKNH
         200       210       220       230       240       250     

        190       200          210       220       230       240   
pF1KB3 SPASLSQASADLEATL---RHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQ
       : ... .:.:. :. :   ...: .   .:.  ..  .  ..: ..  .:.:.:.  :.:
NP_036 STVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKS--FTTNEKA-ILEQ
         260       270       280       290       300          310  

           250       260       270       280       290       300   
pF1KB3 EYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRD
       .. ..   :. ..      ....:. . ..  .:.. : .. . ..  :.  ::  .  :
NP_036 NFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIMDALDERAKVLHEDKQTREQLHSISD
            320       330       340       350       360       370  

           310       320       330         340       350        360
pF1KB3 EFEFLEKASKLRGISTKPVYIPEVELNHKLIKG--IHQSTIDLKNELKQ-CIGRLQELTP
          ::.. . : .  . :   : .   : :..:  . ::  ..:..: . :. .....  
NP_036 SVLFLQEFGALMSNYSLP---PPLPTYHVLLEGEGLGQSLGNFKDDLLNVCMRHVEKMCK
            380       390          400       410       420         

              370       380       390       400       410       420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
                                                                   
NP_036 ADLSRNFIERNHMENGGDHRYVNNYTNSFGGEWSAPDTMKRYSMYLTPKGGVRTSYQPSS
     430       440       450       460       470       480         

>>XP_011541034 (OMIM: 610658) PREDICTED: tripartite moti  (621 aa)
 initn: 296 init1: 296 opt: 424  Z-score: 298.4  bits: 65.4 E(85289): 7e-10
Smith-Waterman score: 424; 28.7% identity (62.7% similar) in 268 aa overlap (100-358:166-427)

      70        80        90       100       110         120       
pF1KB3 CNVVEQFLQADLAREPPADGWTPPARASAPSPNAQVACDHCL--KEAAVKTCLVCMASFC
                                     : . .: :: :.  :. :::.::::.::::
XP_011 RKPTVSIMEPGETRRNSYPRADTGLFSRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFC
         140       150       160       170       180       190     

       130       140       150       160       170       180       
pF1KB3 QEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICLV-EHKAC
       . ::.::... ::.:: :  :.::.  :::  :..  :.::   . :::..:.  :::  
XP_011 ELHLKPHLEGAAFRDHQLLEPIRDFEARKCPVHGKTMELFCQTDQTCICYLCMFQEHKNH
         200       210       220       230       240       250     

        190       200          210       220       230       240   
pF1KB3 SPASLSQASADLEATL---RHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQ
       : ... .:.:. :. :   ...: .   .:.  ..  .  ..: ..  .:.:.:.  :.:
XP_011 STVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKS--FTTNEKA-ILEQ
         260       270       280       290       300          310  

           250       260       270       280       290       300   
pF1KB3 EYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRD
       .. ..   :. ..      ....:. . ..  .:.. : .. . ..  :.  ::  .  :
XP_011 NFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIMDALDERAKVLHEDKQTREQLHSISD
            320       330       340       350       360       370  

           310       320       330         340       350        360
pF1KB3 EFEFLEKASKLRGISTKPVYIPEVELNHKLIKG--IHQSTIDLKNELKQ-CIGRLQELTP
          ::.. . : .  . :   : .   : :..:  . ::  ..:..: . :. .....  
XP_011 SVLFLQEFGALMSNYSLP---PPLPTYHVLLEGEGLGQSLGNFKDDLLNVCMRHVEKMCK
            380       390          400       410       420         

              370       380       390       400       410       420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
                                                                   
XP_011 ADLSRNFIERNHMENGGDHRYVNNYTNSFGGEWSAPDTMKRYSMYLTPKGGVRTSYQPSS
     430       440       450       460       470       480         

>>XP_011541031 (OMIM: 610658) PREDICTED: tripartite moti  (622 aa)
 initn: 296 init1: 296 opt: 424  Z-score: 298.4  bits: 65.4 E(85289): 7e-10
Smith-Waterman score: 424; 28.7% identity (62.7% similar) in 268 aa overlap (100-358:166-427)

      70        80        90       100       110         120       
pF1KB3 CNVVEQFLQADLAREPPADGWTPPARASAPSPNAQVACDHCL--KEAAVKTCLVCMASFC
                                     : . .: :: :.  :. :::.::::.::::
XP_011 RKPTVSIMEPGETRRNSYPRADTGLFSRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFC
         140       150       160       170       180       190     

       130       140       150       160       170       180       
pF1KB3 QEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICLV-EHKAC
       . ::.::... ::.:: :  :.::.  :::  :..  :.::   . :::..:.  :::  
XP_011 ELHLKPHLEGAAFRDHQLLEPIRDFEARKCPVHGKTMELFCQTDQTCICYLCMFQEHKNH
         200       210       220       230       240       250     

        190       200          210       220       230       240   
pF1KB3 SPASLSQASADLEATL---RHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQ
       : ... .:.:. :. :   ...: .   .:.  ..  .  ..: ..  .:.:.:.  :.:
XP_011 STVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKS--FTTNEKA-ILEQ
         260       270       280       290       300          310  

           250       260       270       280       290       300   
pF1KB3 EYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRD
       .. ..   :. ..      ....:. . ..  .:.. : .. . ..  :.  ::  .  :
XP_011 NFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIMDALDERAKVLHEDKQTREQLHSISD
            320       330       340       350       360       370  

           310       320       330         340       350        360
pF1KB3 EFEFLEKASKLRGISTKPVYIPEVELNHKLIKG--IHQSTIDLKNELKQ-CIGRLQELTP
          ::.. . : .  . :   : .   : :..:  . ::  ..:..: . :. .....  
XP_011 SVLFLQEFGALMSNYSLP---PPLPTYHVLLEGEGLGQSLGNFKDDLLNVCMRHVEKMCK
            380       390          400       410       420         

              370       380       390       400       410       420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
                                                                   
XP_011 ADLSRNFIERNHMENGGDHRYVNNYTNSFGGEWSAPDTMKRYSMYLTPKGGVRTSYQPSS
     430       440       450       460       470       480         

>>NP_006461 (OMIM: 609505) tripartite motif-containing p  (564 aa)
 initn: 558 init1: 326 opt: 394  Z-score: 278.9  bits: 61.6 E(85289): 8.5e-09
Smith-Waterman score: 559; 25.4% identity (54.9% similar) in 548 aa overlap (81-617:51-536)

               60        70        80        90       100       110
pF1KB3 PQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADGWTPPARASAPSPNAQVACDHC
                                     :.::   .      ...  . . .: :: :
NP_006 APLSPDSGSPSPDSGSASPVEEEDVGSSEKLGRETEEQDSDSAEQGDPAGEGKEVLCDFC
               30        40        50        60        70        80

                  120       130       140       150        160     
pF1KB3 LKEA----AVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKC-SQHNRLRE
       : ..    :::.::.::...:.::::::  .  .:.: :  ::.:   : : ..:. :  
NP_006 LDDTRRVKAVKSCLTCMVNYCEEHLQPHQVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSA
               90       100       110       120       130       140

         170       180       190       200       210       220     
pF1KB3 FFCPEHSECICHICLVEHKACSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRN
       : ::.. .:::. :  ::.. . .::. :  : :: :.     .  ...    :.. .. 
NP_006 FCCPDQ-QCICQDCCQEHSGHTIVSLDAARRDKEAELQCTQLDLERKLKLNENAISRLQA
               150       160       170       180       190         

         230       240       250       260       270       280     
pF1KB3 RQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKK
        :..: .....     .... :. : .  ....    ..:.:. . :. . :   :  ..
NP_006 NQKSVLVSVSEVKAVAEMQFGELLAAVRKAQANVMLFLEEKEQAALSQANGIKAHLEYRS
     200       210       220       230       240       250         

         290       300       310       320       330       340     
pF1KB3 SEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLK
       .:..  :.:.:.  .  .  .:::.  :..  .:. . .: :              . ::
NP_006 AEMEKSKQELERMAAISNTVQFLEEYCKFK--NTEDITFPSVY-------------VGLK
     260       270       280         290       300                 

         350       360       370       380       390       400     
pF1KB3 NELKQCIGRLQELTPSSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPT
       ..:.   :  . .: :.                 :. ..  :. .::          :  
NP_006 DKLS---GIRKVITEST-----------------VHLIQLLENYKKK----------LQE
             310                        320       330              

         410        420       430       440       450       460    
pF1KB3 FGAPEQLVDLK-QAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYN
       :.  :.  :.. :..  .  :  .:.:. ..             : ..:.:   . .: .
NP_006 FSKEEEY-DIRTQVSAVVQRKYWTSKPEPST-------------REQFLQYAYDITFDPD
          340        350       360                    370       380

          470        480       490       500       510        520  
pF1KB3 TAHNKVALSE-CYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVEL-QKNN
       :::. . :.:    :....   . :   :.:: .  :::. .      .:.:::.   ..
NP_006 TAHKYLRLQEENRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVEIFGAGT
              390       400       410       420       430       440

            530         540       550       560       570       580
pF1KB3 FCGVGICYGSMNRQGPE--SRLGRNSASWCVEWFNTKISAWHNNVEKTLPSTKATRVGVL
       . :.  : : ..:.: :  : .. :. :: ..: . ...::....:  : .    :.:: 
NP_006 YVGL-TCKG-IDRKGEERNSCISGNNFSWSLQWNGKEFTAWYSDMETPLKAGPFRRLGVY
                450       460       470       480       490        

              590        600       610       620       630         
pF1KB3 LNCDHGFVIFFAVA-DKVHLMYKFRVDFTEALYPAFWVFSAGATLSICSPK         
       ..   :.. :..:  : . :..::   :.: .: :::.                      
NP_006 IDFPGGILSFYGVEYDTMTLVHKFACKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAPS
      500       510       520       530       540       550        

NP_006 LVGTAP
      560    

>>XP_006717401 (OMIM: 606556) PREDICTED: tripartite moti  (392 aa)
 initn: 247 init1: 107 opt: 321  Z-score: 232.4  bits: 52.5 E(85289): 3.3e-06
Smith-Waterman score: 344; 26.1% identity (53.8% similar) in 398 aa overlap (236-616:16-382)

         210       220       230       240       250       260     
pF1KB3 LTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKE
                                     .....:.::  .. :.   ..  .  .:..
XP_006                MTLGKLPHLQMPPLEKNTRKLSQECLKQLAIKKQQHIDNITQIED
                              10        20        30        40     

         270       280       290       300       310       320     
pF1KB3 EEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIP
         ...... ..    :  : .:.. : .: :..:.:.    :..: ..:    :  ::  
XP_006 ATEKLKANAESSKTWLKGKFTELRLLLDE-EEALAKK----FIDKNTQL----TLQVYRE
          50        60        70         80                90      

         330       340       350       360       370       380     
pF1KB3 EVELNHKLIKGIHQSTIDLKNELKQCIGRLQELTPSSGDPGEHDPASTHKSTRPVKKVSK
       ...  ..         .:. :.:.. .  ...  :   :: ..  : :    .  ...: 
XP_006 QADSCRE--------QLDIMNDLSNRVWSISQ-EP---DPVQRLQAYTATEQEMQQQMSL
        100               110       120           130       140    

         390       400       410       420           430       440 
pF1KB3 EEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATS----SHPNSTSLKAKVL
        :    .: :.   : :    :  : . .  :. :.   : .     : :.::.  . .:
XP_006 GELC--HPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTK-PGTLL
            150       160       170       180       190        200 

             450       460       470             480       490     
pF1KB3 ETFLAKSRPELLEYYIKVILDYNTAHNKVALS------ECYTVASVAEMPQNYRPHPQRF
       .:  .  :  ::.:     :: .: : .. ::      .:  ..:.. .:        ::
XP_006 KTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVPV------LRF
             210       220       230       240       250           

         500       510       520         530       540         550 
pF1KB3 TYCSQVLGLHCYKKGIHYWEVELQKNNFCG--VGICYGSMNRQGPES--RLGRNSASWCV
           :::.  :.  : :::::..:. .  :  ::  :.:. :.:  .  ::: :  :::.
XP_006 DALWQVLARDCFATGRHYWEVDVQEAG-AGWWVGAAYASLRRRGASAAARLGCNRQSWCL
         260       270       280        290       300       310    

             560        570       580       590       600       610
pF1KB3 EWFNTKISAWHNNVEKTL-PSTKATRVGVLLNCDHGFVIFFAVADKVHLMYKFRVDFTEA
       . .. .  :.:.. .. : :     :.::.:. . : . :. :.  .  .. ::. : : 
XP_006 KRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEP
          320       330       340       350       360       370    

                620       630
pF1KB3 LYPAF--WVFSAGATLSICSPK
       ::::.  :              
XP_006 LYPALRLWEGAISIPRLP    
          380       390      

>>XP_011517546 (OMIM: 606556) PREDICTED: tripartite moti  (285 aa)
 initn: 247 init1: 107 opt: 315  Z-score: 230.1  bits: 51.6 E(85289): 4.4e-06
Smith-Waterman score: 315; 29.3% identity (54.4% similar) in 270 aa overlap (367-616:14-275)

        340       350       360       370        380       390     
pF1KB3 IHQSTIDLKNELKQCIGRLQELTPSSGDPGEHDPASTHKS-TRPVKKVSKEEKKSKKPPP
                                     : ::..  .. :   ...... . ..   :
XP_011                  MNDLSNRVWSISQEPDPVQRLQAYTATEQEMQQQMSLGELCHP
                                10        20        30        40   

         400         410       420           430       440         
pF1KB3 VPALPSKLPTF--GAPEQLVDLKQAGLEAAAKATS----SHPNSTSLKAKVLETFLAKSR
       ::     . .:  :  : . .  :. :.   : .     : :.::.  . .:.:  .  :
XP_011 VPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTK-PGTLLKTSPSPER
            50        60        70        80         90       100  

     450       460       470             480       490       500   
pF1KB3 PELLEYYIKVILDYNTAHNKVALS------ECYTVASVAEMPQNYRPHPQRFTYCSQVLG
         ::.:     :: .: : .. ::      .:  ..:.. .:        ::    :::.
XP_011 SLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVP------VLRFDALWQVLA
            110       120       130       140             150      

           510       520         530       540         550         
pF1KB3 LHCYKKGIHYWEVELQKNNFCG--VGICYGSMNRQGPES--RLGRNSASWCVEWFNTKIS
         :.  : :::::..:. .  :  ::  :.:. :.:  .  ::: :  :::.. .. .  
XP_011 RDCFATGRHYWEVDVQEAG-AGWWVGAAYASLRRRGASAAARLGCNRQSWCLKRYDLEYW
        160       170        180       190       200       210     

     560        570       580       590       600       610        
pF1KB3 AWHNNVEKTL-PSTKATRVGVLLNCDHGFVIFFAVADKVHLMYKFRVDFTEALYPAF--W
       :.:.. .. : :     :.::.:. . : . :. :.  .  .. ::. : : ::::.  :
XP_011 AFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLW
         220       230       240       250       260       270     

        620       630
pF1KB3 VFSAGATLSICSPK
                     
XP_011 EGAISIPRLP    
         280         

>>XP_016870841 (OMIM: 606556) PREDICTED: tripartite moti  (442 aa)
 initn: 275 init1: 107 opt: 317  Z-score: 229.1  bits: 52.1 E(85289): 5.1e-06
Smith-Waterman score: 377; 25.7% identity (52.8% similar) in 479 aa overlap (156-616:23-432)

         130       140       150       160        170       180    
pF1KB3 FCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQH-NRLREFFCPEHSECICHICLV--E
                                     .: .: .:. :.:: .  .:.: .: :   
XP_016         MAGAATGSRTPGRSELVEGCGWRCPEHGDRVAELFCRRCRRCVCALCPVLGA
                       10        20        30        40        50  

            190        200       210       220       230       240 
pF1KB3 HKACSPASLS-QASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQL
       :..  :..:. .:.. ..   .. :  .  . .     . ....  . .. .:. .   :
XP_016 HRG-HPVGLALEAAVHVQKLSQECLKQLAIKKQQHIDNITQIEDATEKLKANAESSKTWL
              60        70        80        90       100       110 

             250       260       270       280       290       300 
pF1KB3 QQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTK
       . ..::.. :::            ::. . .::       . :.... ::.   ::. . 
XP_016 KGKFTELRLLLD------------EEEALAKKF-------IDKNTQL-TLQVYREQADSC
             120                   130               140       150 

             310        320       330       340       350       360
pF1KB3 RDEFEFLEKAS-KLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQELTP
       :.......  : .. .:: .:  . ..           :.    ..:..: .. : ::  
XP_016 REQLDIMNDLSNRVWSISQEPDPVQRL-----------QAYTATEQEMQQQMS-LGELC-
             160       170                  180       190          

              370       380       390       400       410       420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
              : :.    : .:::.  :          : :. : : :   :   .:..   :
XP_016 -------H-PVPL--SFEPVKSFFKGL--------VEAVESTLQT---P---LDIR---L
              200         210               220             230    

              430       440       450       460       470          
pF1KB3 EAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYNTAHNKVALS------E
       . . .   : :.::.  . .:.:  .  :  ::.:     :: .: : .. ::      .
XP_016 KESINCQLSDPSSTK-PGTLLKTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVR
             240        250       260       270       280       290

          480       490       500       510       520         530  
pF1KB3 CYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCG--VGICYGS
       :  ..:.. .:        ::    :::.  :.  : :::::..:. .  :  ::  :.:
XP_016 CGLLGSLGPVPV------LRFDALWQVLARDCFATGRHYWEVDVQEAG-AGWWVGAAYAS
              300             310       320       330        340   

            540         550       560        570       580         
pF1KB3 MNRQGPES--RLGRNSASWCVEWFNTKISAWHNNVEKTL-PSTKATRVGVLLNCDHGFVI
       . :.:  .  ::: :  :::.. .. .  :.:.. .. : :     :.::.:. . : . 
XP_016 LRRRGASAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLA
           350       360       370       380       390       400   

     590       600       610         620       630
pF1KB3 FFAVADKVHLMYKFRVDFTEALYPAF--WVFSAGATLSICSPK
       :. :.  .  .. ::. : : ::::.  :              
XP_016 FYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIPRLP    
           410       420       430       440      

>>NP_150088 (OMIM: 606556) tripartite motif-containing p  (442 aa)
 initn: 275 init1: 107 opt: 317  Z-score: 229.1  bits: 52.1 E(85289): 5.1e-06
Smith-Waterman score: 377; 25.7% identity (52.8% similar) in 479 aa overlap (156-616:23-432)

         130       140       150       160        170       180    
pF1KB3 FCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQH-NRLREFFCPEHSECICHICLV--E
                                     .: .: .:. :.:: .  .:.: .: :   
NP_150         MAGAATGSRTPGRSELVEGCGWRCPEHGDRVAELFCRRCRRCVCALCPVLGA
                       10        20        30        40        50  

            190        200       210       220       230       240 
pF1KB3 HKACSPASLS-QASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQL
       :..  :..:. .:.. ..   .. :  .  . .     . ....  . .. .:. .   :
NP_150 HRG-HPVGLALEAAVHVQKLSQECLKQLAIKKQQHIDNITQIEDATEKLKANAESSKTWL
              60        70        80        90       100       110 

             250       260       270       280       290       300 
pF1KB3 QQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTK
       . ..::.. :::            ::. . .::       . :.... ::.   ::. . 
NP_150 KGKFTELRLLLD------------EEEALAKKF-------IDKNTQL-TLQVYREQADSC
             120                   130               140       150 

             310        320       330       340       350       360
pF1KB3 RDEFEFLEKAS-KLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQELTP
       :.......  : .. .:: .:  . ..           :.    ..:..: .. : ::  
NP_150 REQLDIMNDLSNRVWSISQEPDPVQRL-----------QAYTATEQEMQQQMS-LGELC-
             160       170                  180       190          

              370       380       390       400       410       420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
              : :.    : .:::.  :          : :. : : :   :   .:..   :
NP_150 -------H-PVPL--SFEPVKSFFKGL--------VEAVESTLQT---P---LDIR---L
              200         210               220             230    

              430       440       450       460       470          
pF1KB3 EAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYNTAHNKVALS------E
       . . .   : :.::.  . .:.:  .  :  ::.:     :: .: : .. ::      .
NP_150 KESINCQLSDPSSTK-PGTLLKTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVR
             240        250       260       270       280       290

          480       490       500       510       520         530  
pF1KB3 CYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCG--VGICYGS
       :  ..:.. .:        ::    :::.  :.  : :::::..:. .  :  ::  :.:
NP_150 CGLLGSLGPVPV------LRFDALWQVLARDCFATGRHYWEVDVQEAG-AGWWVGAAYAS
              300             310       320       330        340   

            540         550       560        570       580         
pF1KB3 MNRQGPES--RLGRNSASWCVEWFNTKISAWHNNVEKTL-PSTKATRVGVLLNCDHGFVI
       . :.:  .  ::: :  :::.. .. .  :.:.. .. : :     :.::.:. . : . 
NP_150 LRRRGASAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLA
           350       360       370       380       390       400   

     590       600       610         620       630
pF1KB3 FFAVADKVHLMYKFRVDFTEALYPAF--WVFSAGATLSICSPK
       :. :.  .  .. ::. : : ::::.  :              
NP_150 FYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIPRLP    
           410       420       430       440      

>>XP_016870842 (OMIM: 606556) PREDICTED: tripartite moti  (442 aa)
 initn: 275 init1: 107 opt: 317  Z-score: 229.1  bits: 52.1 E(85289): 5.1e-06
Smith-Waterman score: 377; 25.7% identity (52.8% similar) in 479 aa overlap (156-616:23-432)

         130       140       150       160        170       180    
pF1KB3 FCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQH-NRLREFFCPEHSECICHICLV--E
                                     .: .: .:. :.:: .  .:.: .: :   
XP_016         MAGAATGSRTPGRSELVEGCGWRCPEHGDRVAELFCRRCRRCVCALCPVLGA
                       10        20        30        40        50  

            190        200       210       220       230       240 
pF1KB3 HKACSPASLS-QASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQL
       :..  :..:. .:.. ..   .. :  .  . .     . ....  . .. .:. .   :
XP_016 HRG-HPVGLALEAAVHVQKLSQECLKQLAIKKQQHIDNITQIEDATEKLKANAESSKTWL
              60        70        80        90       100       110 

             250       260       270       280       290       300 
pF1KB3 QQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTK
       . ..::.. :::            ::. . .::       . :.... ::.   ::. . 
XP_016 KGKFTELRLLLD------------EEEALAKKF-------IDKNTQL-TLQVYREQADSC
             120                   130               140       150 

             310        320       330       340       350       360
pF1KB3 RDEFEFLEKAS-KLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQELTP
       :.......  : .. .:: .:  . ..           :.    ..:..: .. : ::  
XP_016 REQLDIMNDLSNRVWSISQEPDPVQRL-----------QAYTATEQEMQQQMS-LGELC-
             160       170                  180       190          

              370       380       390       400       410       420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
              : :.    : .:::.  :          : :. : : :   :   .:..   :
XP_016 -------H-PVPL--SFEPVKSFFKGL--------VEAVESTLQT---P---LDIR---L
              200         210               220             230    

              430       440       450       460       470          
pF1KB3 EAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYNTAHNKVALS------E
       . . .   : :.::.  . .:.:  .  :  ::.:     :: .: : .. ::      .
XP_016 KESINCQLSDPSSTK-PGTLLKTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVR
             240        250       260       270       280       290

          480       490       500       510       520         530  
pF1KB3 CYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCG--VGICYGS
       :  ..:.. .:        ::    :::.  :.  : :::::..:. .  :  ::  :.:
XP_016 CGLLGSLGPVPV------LRFDALWQVLARDCFATGRHYWEVDVQEAG-AGWWVGAAYAS
              300             310       320       330        340   

            540         550       560        570       580         
pF1KB3 MNRQGPES--RLGRNSASWCVEWFNTKISAWHNNVEKTL-PSTKATRVGVLLNCDHGFVI
       . :.:  .  ::: :  :::.. .. .  :.:.. .. : :     :.::.:. . : . 
XP_016 LRRRGASAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLA
           350       360       370       380       390       400   

     590       600       610         620       630
pF1KB3 FFAVADKVHLMYKFRVDFTEALYPAF--WVFSAGATLSICSPK
       :. :.  .  .. ::. : : ::::.  :              
XP_016 FYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIPRLP    
           410       420       430       440      




630 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 13:25:36 2016 done: Thu Nov  3 13:25:37 2016
 Total Scan time: 11.480 Total Display time:  0.060

Function used was FASTA [36.3.4 Apr, 2011]
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