Result of FASTA (omim) for pF1KB3334
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3334, 770 aa
  1>>>pF1KB3334 770 - 770 aa - 770 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.4921+/-0.000476; mu= 6.1549+/- 0.030
 mean_var=226.5313+/-44.441, 0's: 0 Z-trim(116.2): 104  B-trim: 0 in 0/53
 Lambda= 0.085214
 statistics sampled from 27159 (27263) to 27159 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.656), E-opt: 0.2 (0.32), width:  16
 Scan time: 11.400

The best scores are:                                      opt bits E(85289)
NP_000475 (OMIM: 104300,104760,605714) amyloid bet ( 770) 5160 648.3 3.5e-185
NP_001129602 (OMIM: 104300,104760,605714) amyloid  ( 714) 4648 585.3 2.9e-166
NP_001191230 (OMIM: 104300,104760,605714) amyloid  ( 752) 4294 541.8 3.8e-153
NP_001129488 (OMIM: 104300,104760,605714) amyloid  ( 746) 2674 342.7 3.4e-93
NP_958816 (OMIM: 104300,104760,605714) amyloid bet ( 751) 2674 342.7 3.4e-93
NP_001129601 (OMIM: 104300,104760,605714) amyloid  ( 639) 2653 340.0 1.8e-92
NP_001129603 (OMIM: 104300,104760,605714) amyloid  ( 660) 2653 340.1 1.9e-92
NP_958817 (OMIM: 104300,104760,605714) amyloid bet ( 695) 2653 340.1 1.9e-92
NP_001191231 (OMIM: 104300,104760,605714) amyloid  ( 733) 2431 312.8 3.3e-84
NP_001191232 (OMIM: 104300,104760,605714) amyloid  ( 677) 1977 257.0   2e-67
NP_001315615 (OMIM: 104776) amyloid-like protein 2 ( 730) 1295 173.1 3.6e-42
NP_001633 (OMIM: 104776) amyloid-like protein 2 is ( 763) 1295 173.2 3.7e-42
NP_001315611 (OMIM: 104776) amyloid-like protein 2 ( 707) 1269 169.9 3.2e-41
NP_001135748 (OMIM: 104776) amyloid-like protein 2 ( 751)  985 135.0 1.1e-30
NP_001230228 (OMIM: 104776) amyloid-like protein 2 ( 761)  985 135.0 1.1e-30
NP_001135749 (OMIM: 104776) amyloid-like protein 2 ( 695)  959 131.8 9.5e-30
NP_001135750 (OMIM: 104776) amyloid-like protein 2 ( 522)  949 130.5 1.8e-29
NP_001315613 (OMIM: 104776) amyloid-like protein 2 ( 700)  924 127.5 1.9e-28
NP_001315614 (OMIM: 104776) amyloid-like protein 2 ( 644)  898 124.3 1.6e-27
XP_016882227 (OMIM: 104775) PREDICTED: amyloid-lik ( 597)  695 99.3   5e-20
XP_016882226 (OMIM: 104775) PREDICTED: amyloid-lik ( 598)  695 99.3   5e-20
NP_001019978 (OMIM: 104775) amyloid-like protein 1 ( 651)  685 98.1 1.3e-19
NP_005157 (OMIM: 104775) amyloid-like protein 1 is ( 650)  683 97.9 1.5e-19
NP_001159575 (OMIM: 270420,605124) kunitz-type pro ( 195)  236 42.4  0.0022
NP_066925 (OMIM: 270420,605124) kunitz-type protea ( 252)  236 42.5  0.0026
NP_006643 (OMIM: 613941) kunitz-type protease inhi (  89)  224 40.6  0.0034


>>NP_000475 (OMIM: 104300,104760,605714) amyloid beta A4  (770 aa)
 initn: 5160 init1: 5160 opt: 5160  Z-score: 3445.7  bits: 648.3 E(85289): 3.5e-185
Smith-Waterman score: 5160; 100.0% identity (100.0% similar) in 770 aa overlap (1-770:1-770)

               10        20        30        40        50        60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
              670       680       690       700       710       720

              730       740       750       760       770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
              730       740       750       760       770

>>NP_001129602 (OMIM: 104300,104760,605714) amyloid beta  (714 aa)
 initn: 4648 init1: 4648 opt: 4648  Z-score: 3105.9  bits: 585.3 E(85289): 2.9e-166
Smith-Waterman score: 4648; 100.0% identity (100.0% similar) in 696 aa overlap (75-770:19-714)

           50        60        70        80        90       100    
pF1KB3 MNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQ
                                     ::::::::::::::::::::::::::::::
NP_001             MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQ
                           10        20        30        40        

          110       120       130       140       150       160    
pF1KB3 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
       50        60        70        80        90       100        

          170       180       190       200       210       220    
pF1KB3 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
      110       120       130       140       150       160        

          230       240       250       260       270       280    
pF1KB3 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
      170       180       190       200       210       220        

          290       300       310       320       330       340    
pF1KB3 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
      230       240       250       260       270       280        

          350       360       370       380       390       400    
pF1KB3 MSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
      290       300       310       320       330       340        

          410       420       430       440       450       460    
pF1KB3 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
      350       360       370       380       390       400        

          470       480       490       500       510       520    
pF1KB3 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
      410       420       430       440       450       460        

          530       540       550       560       570       580    
pF1KB3 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
      470       480       490       500       510       520        

          590       600       610       620       630       640    
pF1KB3 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
      530       540       550       560       570       580        

          650       660       670       680       690       700    
pF1KB3 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
      590       600       610       620       630       640        

          710       720       730       740       750       760    
pF1KB3 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
      650       660       670       680       690       700        

          770
pF1KB3 FEQMQN
       ::::::
NP_001 FEQMQN
      710    

>>NP_001191230 (OMIM: 104300,104760,605714) amyloid beta  (752 aa)
 initn: 4294 init1: 4294 opt: 4294  Z-score: 2870.4  bits: 541.8 E(85289): 3.8e-153
Smith-Waterman score: 4993; 97.7% identity (97.7% similar) in 770 aa overlap (1-770:1-752)

               10        20        30        40        50        60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
       ::::::::::::::::::::::::::::::::::::                  ::::::
NP_001 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE------------------GSGLTN
              610       620       630                         640  

              670       680       690       700       710       720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
            650       660       670       680       690       700  

              730       740       750       760       770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
            710       720       730       740       750  

>>NP_001129488 (OMIM: 104300,104760,605714) amyloid beta  (746 aa)
 initn: 2640 init1: 2640 opt: 2674  Z-score: 1794.1  bits: 342.7 E(85289): 3.4e-93
Smith-Waterman score: 4872; 97.3% identity (97.5% similar) in 751 aa overlap (20-770:15-746)

               10        20        30        40        50        60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
                          :::::::::::::::::::::::::::::::::::::::::
NP_001      MDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
                    10        20        30        40        50     

               70        80        90       100       110       120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
          60        70        80        90       100       110     

              130       140       150       160       170       180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
         120       130       140       150       160       170     

              190       200       210       220       230       240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
         180       190       200       210       220       230     

              250       260       270       280       290       300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
         240       250       260       270       280       290     

              310       320       330       340       350       360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
       ::::::::::::::::::::::::::::::::::::::::::::.               
NP_001 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAI---------------
         300       310       320       330       340               

              370       380       390       400       410       420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
           ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
                  350       360       370       380       390      

              430       440       450       460       470       480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
        400       410       420       430       440       450      

              490       500       510       520       530       540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
        460       470       480       490       500       510      

              550       560       570       580       590       600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
        520       530       540       550       560       570      

              610       620       630       640       650       660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
        580       590       600       610       620       630      

              670       680       690       700       710       720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
        640       650       660       670       680       690      

              730       740       750       760       770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
        700       710       720       730       740      

>>NP_958816 (OMIM: 104300,104760,605714) amyloid beta A4  (751 aa)
 initn: 2640 init1: 2640 opt: 2674  Z-score: 1794.1  bits: 342.7 E(85289): 3.4e-93
Smith-Waterman score: 4990; 97.4% identity (97.5% similar) in 770 aa overlap (1-770:1-751)

               10        20        30        40        50        60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
       ::::::::::::::::::::::::::::::::::::::::::::.               
NP_958 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAI---------------
              310       320       330       340                    

              370       380       390       400       410       420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
           ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 ----PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
             350       360       370       380       390       400 

              430       440       450       460       470       480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
             410       420       430       440       450       460 

              490       500       510       520       530       540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
             470       480       490       500       510       520 

              550       560       570       580       590       600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
             530       540       550       560       570       580 

              610       620       630       640       650       660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
             590       600       610       620       630       640 

              670       680       690       700       710       720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
             650       660       670       680       690       700 

              730       740       750       760       770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
             710       720       730       740       750 

>>NP_001129601 (OMIM: 104300,104760,605714) amyloid beta  (639 aa)
 initn: 2759 init1: 2650 opt: 2653  Z-score: 1781.0  bits: 340.0 E(85289): 1.8e-92
Smith-Waterman score: 3944; 89.1% identity (89.2% similar) in 696 aa overlap (75-770:19-639)

           50        60        70        80        90       100    
pF1KB3 MNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQ
                                     ::::::::::::::::::::::::::::::
NP_001             MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQ
                           10        20        30        40        

          110       120       130       140       150       160    
pF1KB3 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
       50        60        70        80        90       100        

          170       180       190       200       210       220    
pF1KB3 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
      110       120       130       140       150       160        

          230       240       250       260       270       280    
pF1KB3 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
      170       180       190       200       210       220        

          290       300       310       320       330       340    
pF1KB3 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
       ::::                                                        
NP_001 EVVR--------------------------------------------------------
      230                                                          

          350       360       370       380       390       400    
pF1KB3 MSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
                          .::::::::::::::::::::::::::::::::::::::::
NP_001 -------------------VPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
                               240       250       260       270   

          410       420       430       440       450       460    
pF1KB3 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
           280       290       300       310       320       330   

          470       480       490       500       510       520    
pF1KB3 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
           340       350       360       370       380       390   

          530       540       550       560       570       580    
pF1KB3 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
           400       410       420       430       440       450   

          590       600       610       620       630       640    
pF1KB3 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
           460       470       480       490       500       510   

          650       660       670       680       690       700    
pF1KB3 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
           520       530       540       550       560       570   

          710       720       730       740       750       760    
pF1KB3 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
           580       590       600       610       620       630   

          770
pF1KB3 FEQMQN
       ::::::
NP_001 FEQMQN
             

>>NP_001129603 (OMIM: 104300,104760,605714) amyloid beta  (660 aa)
 initn: 2650 init1: 2650 opt: 2653  Z-score: 1780.9  bits: 340.1 E(85289): 1.9e-92
Smith-Waterman score: 4234; 89.7% identity (89.8% similar) in 735 aa overlap (36-770:1-660)

          10        20        30        40        50        60     
pF1KB3 ALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDT
                                     ::::::::::::::::::::::::::::::
NP_001                               MFCGRLNMHMNVQNGKWDSDPSGTKTCIDT
                                             10        20        30

          70        80        90       100       110       120     
pF1KB3 KEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSD
               40        50        60        70        80        90

         130       140       150       160       170       180     
pF1KB3 ALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV
              100       110       120       130       140       150

         190       200       210       220       230       240     
pF1KB3 CCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDD
              160       170       180       190       200       210

         250       260       270       280       290       300     
pF1KB3 EDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMIS
       :::::::::::::::::::::::::::::::::::::::::::                 
NP_001 EDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR-----------------
              220       230       240       250                    

         310       320       330       340       350       360     
pF1KB3 RWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLP
                                                                 .:
NP_001 ----------------------------------------------------------VP
                                                                   

         370       380       390       400       410       420     
pF1KB3 TTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPK
         260       270       280       290       300       310     

         430       440       450       460       470       480     
pF1KB3 ADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPP
         320       330       340       350       360       370     

         490       500       510       520       530       540     
pF1KB3 RPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSL
         380       390       400       410       420       430     

         550       560       570       580       590       600     
pF1KB3 SLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVE
         440       450       460       470       480       490     

         610       620       630       640       650       660     
pF1KB3 LLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEE
         500       510       520       530       540       550     

         670       680       690       700       710       720     
pF1KB3 ISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKK
         560       570       580       590       600       610     

         730       740       750       760       770
pF1KB3 KQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       :::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
         620       630       640       650       660

>>NP_958817 (OMIM: 104300,104760,605714) amyloid beta A4  (695 aa)
 initn: 2650 init1: 2650 opt: 2653  Z-score: 1780.6  bits: 340.1 E(85289): 1.9e-92
Smith-Waterman score: 4456; 90.1% identity (90.3% similar) in 770 aa overlap (1-770:1-695)

               10        20        30        40        50        60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
       ::::::::::::::::::::::::::::::::::::::::::::::::            
NP_958 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR------------
              250       260       270       280                    

              310       320       330       340       350       360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
                                                                   
NP_958 ------------------------------------------------------------
                                                                   

              370       380       390       400       410       420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
          .::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 ---VPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
         290       300       310       320       330       340     

              430       440       450       460       470       480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
         350       360       370       380       390       400     

              490       500       510       520       530       540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
         410       420       430       440       450       460     

              550       560       570       580       590       600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
         470       480       490       500       510       520     

              610       620       630       640       650       660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
         530       540       550       560       570       580     

              670       680       690       700       710       720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
         590       600       610       620       630       640     

              730       740       750       760       770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
         650       660       670       680       690     

>>NP_001191231 (OMIM: 104300,104760,605714) amyloid beta  (733 aa)
 initn: 3134 init1: 2401 opt: 2431  Z-score: 1632.8  bits: 312.8 E(85289): 3.3e-84
Smith-Waterman score: 4823; 95.1% identity (95.2% similar) in 770 aa overlap (1-770:1-733)

               10        20        30        40        50        60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
       ::::::::::::::::::::::::::::::::::::::::::::.               
NP_001 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAI---------------
              310       320       330       340                    

              370       380       390       400       410       420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
           ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
             350       360       370       380       390       400 

              430       440       450       460       470       480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
             410       420       430       440       450       460 

              490       500       510       520       530       540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
             470       480       490       500       510       520 

              550       560       570       580       590       600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
             530       540       550       560       570       580 

              610       620       630       640       650       660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
       ::::::::::::::::::::::::::::::::::::                  ::::::
NP_001 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE------------------GSGLTN
             590       600       610                         620   

              670       680       690       700       710       720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
           630       640       650       660       670       680   

              730       740       750       760       770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
           690       700       710       720       730   

>>NP_001191232 (OMIM: 104300,104760,605714) amyloid beta  (677 aa)
 initn: 2710 init1: 1977 opt: 1977  Z-score: 1331.6  bits: 257.0 E(85289): 2e-67
Smith-Waterman score: 4289; 87.8% identity (87.9% similar) in 770 aa overlap (1-770:1-677)

               10        20        30        40        50        60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
       ::::::::::::::::::::::::::::::::::::::::::::::::            
NP_001 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR------------
              250       260       270       280                    

              310       320       330       340       350       360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
                                                                   
NP_001 ------------------------------------------------------------
                                                                   

              370       380       390       400       410       420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
          .::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ---VPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
         290       300       310       320       330       340     

              430       440       450       460       470       480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
         350       360       370       380       390       400     

              490       500       510       520       530       540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
         410       420       430       440       450       460     

              550       560       570       580       590       600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
         470       480       490       500       510       520     

              610       620       630       640       650       660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
       ::::::::::::::::::::::::::::::::::::                  ::::::
NP_001 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE------------------GSGLTN
         530       540       550       560                         

              670       680       690       700       710       720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
       570       580       590       600       610       620       

              730       740       750       760       770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       630       640       650       660       670       




770 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 12:55:04 2016 done: Thu Nov  3 12:55:05 2016
 Total Scan time: 11.400 Total Display time:  0.180

Function used was FASTA [36.3.4 Apr, 2011]
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