Result of FASTA (ccds) for pF1KB3334
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3334, 770 aa
  1>>>pF1KB3334 770 - 770 aa - 770 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.7925+/-0.00113; mu= 4.5811+/- 0.068
 mean_var=210.0723+/-41.158, 0's: 0 Z-trim(108.8): 49  B-trim: 0 in 0/51
 Lambda= 0.088489
 statistics sampled from 10408 (10445) to 10408 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.321), width:  16
 Scan time:  3.800

The best scores are:                                      opt bits E(32554)
CCDS13576.1 APP gene_id:351|Hs108|chr21            ( 770) 5160 672.3 7.8e-193
CCDS46639.1 APP gene_id:351|Hs108|chr21            ( 714) 4648 607.0 3.5e-173
CCDS56213.1 APP gene_id:351|Hs108|chr21            ( 752) 4294 561.8 1.5e-159
CCDS56212.1 APP gene_id:351|Hs108|chr21            ( 746) 2674 355.0 2.6e-97
CCDS33523.1 APP gene_id:351|Hs108|chr21            ( 751) 2674 355.0 2.6e-97
CCDS46638.1 APP gene_id:351|Hs108|chr21            ( 639) 2653 352.2 1.5e-96
CCDS56211.1 APP gene_id:351|Hs108|chr21            ( 660) 2653 352.2 1.5e-96
CCDS13577.1 APP gene_id:351|Hs108|chr21            ( 695) 2653 352.3 1.6e-96
CCDS8486.1 APLP2 gene_id:334|Hs108|chr11           ( 763) 1295 178.9 2.6e-44
CCDS44773.1 APLP2 gene_id:334|Hs108|chr11          ( 751)  985 139.3 2.1e-32
CCDS58196.1 APLP2 gene_id:334|Hs108|chr11          ( 761)  985 139.3 2.1e-32
CCDS44774.1 APLP2 gene_id:334|Hs108|chr11          ( 695)  959 136.0   2e-31
CCDS44775.1 APLP2 gene_id:334|Hs108|chr11          ( 522)  949 134.6 3.9e-31
CCDS32997.1 APLP1 gene_id:333|Hs108|chr19          ( 651)  685 101.0 6.4e-21


>>CCDS13576.1 APP gene_id:351|Hs108|chr21                 (770 aa)
 initn: 5160 init1: 5160 opt: 5160  Z-score: 3575.5  bits: 672.3 E(32554): 7.8e-193
Smith-Waterman score: 5160; 100.0% identity (100.0% similar) in 770 aa overlap (1-770:1-770)

               10        20        30        40        50        60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
              670       680       690       700       710       720

              730       740       750       760       770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
              730       740       750       760       770

>>CCDS46639.1 APP gene_id:351|Hs108|chr21                 (714 aa)
 initn: 4648 init1: 4648 opt: 4648  Z-score: 3222.7  bits: 607.0 E(32554): 3.5e-173
Smith-Waterman score: 4648; 100.0% identity (100.0% similar) in 696 aa overlap (75-770:19-714)

           50        60        70        80        90       100    
pF1KB3 MNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQ
                                     ::::::::::::::::::::::::::::::
CCDS46             MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQ
                           10        20        30        40        

          110       120       130       140       150       160    
pF1KB3 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
       50        60        70        80        90       100        

          170       180       190       200       210       220    
pF1KB3 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
      110       120       130       140       150       160        

          230       240       250       260       270       280    
pF1KB3 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
      170       180       190       200       210       220        

          290       300       310       320       330       340    
pF1KB3 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
      230       240       250       260       270       280        

          350       360       370       380       390       400    
pF1KB3 MSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 MSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
      290       300       310       320       330       340        

          410       420       430       440       450       460    
pF1KB3 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
      350       360       370       380       390       400        

          470       480       490       500       510       520    
pF1KB3 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
      410       420       430       440       450       460        

          530       540       550       560       570       580    
pF1KB3 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
      470       480       490       500       510       520        

          590       600       610       620       630       640    
pF1KB3 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
      530       540       550       560       570       580        

          650       660       670       680       690       700    
pF1KB3 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
      590       600       610       620       630       640        

          710       720       730       740       750       760    
pF1KB3 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
      650       660       670       680       690       700        

          770
pF1KB3 FEQMQN
       ::::::
CCDS46 FEQMQN
      710    

>>CCDS56213.1 APP gene_id:351|Hs108|chr21                 (752 aa)
 initn: 4294 init1: 4294 opt: 4294  Z-score: 2978.2  bits: 561.8 E(32554): 1.5e-159
Smith-Waterman score: 4993; 97.7% identity (97.7% similar) in 770 aa overlap (1-770:1-752)

               10        20        30        40        50        60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
       ::::::::::::::::::::::::::::::::::::                  ::::::
CCDS56 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE------------------GSGLTN
              610       620       630                         640  

              670       680       690       700       710       720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
            650       660       670       680       690       700  

              730       740       750       760       770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
            710       720       730       740       750  

>>CCDS56212.1 APP gene_id:351|Hs108|chr21                 (746 aa)
 initn: 2640 init1: 2640 opt: 2674  Z-score: 1860.5  bits: 355.0 E(32554): 2.6e-97
Smith-Waterman score: 4872; 97.3% identity (97.5% similar) in 751 aa overlap (20-770:15-746)

               10        20        30        40        50        60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
                          :::::::::::::::::::::::::::::::::::::::::
CCDS56      MDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
                    10        20        30        40        50     

               70        80        90       100       110       120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
          60        70        80        90       100       110     

              130       140       150       160       170       180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
         120       130       140       150       160       170     

              190       200       210       220       230       240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
         180       190       200       210       220       230     

              250       260       270       280       290       300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
         240       250       260       270       280       290     

              310       320       330       340       350       360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
       ::::::::::::::::::::::::::::::::::::::::::::.               
CCDS56 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAI---------------
         300       310       320       330       340               

              370       380       390       400       410       420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
           ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ----PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
                  350       360       370       380       390      

              430       440       450       460       470       480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
        400       410       420       430       440       450      

              490       500       510       520       530       540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
        460       470       480       490       500       510      

              550       560       570       580       590       600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
        520       530       540       550       560       570      

              610       620       630       640       650       660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
        580       590       600       610       620       630      

              670       680       690       700       710       720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
        640       650       660       670       680       690      

              730       740       750       760       770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
        700       710       720       730       740      

>>CCDS33523.1 APP gene_id:351|Hs108|chr21                 (751 aa)
 initn: 2640 init1: 2640 opt: 2674  Z-score: 1860.5  bits: 355.0 E(32554): 2.6e-97
Smith-Waterman score: 4990; 97.4% identity (97.5% similar) in 770 aa overlap (1-770:1-751)

               10        20        30        40        50        60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
       ::::::::::::::::::::::::::::::::::::::::::::.               
CCDS33 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAI---------------
              310       320       330       340                    

              370       380       390       400       410       420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
           ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 ----PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
             350       360       370       380       390       400 

              430       440       450       460       470       480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
             410       420       430       440       450       460 

              490       500       510       520       530       540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
             470       480       490       500       510       520 

              550       560       570       580       590       600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
             530       540       550       560       570       580 

              610       620       630       640       650       660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
             590       600       610       620       630       640 

              670       680       690       700       710       720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
             650       660       670       680       690       700 

              730       740       750       760       770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
             710       720       730       740       750 

>>CCDS46638.1 APP gene_id:351|Hs108|chr21                 (639 aa)
 initn: 2759 init1: 2650 opt: 2653  Z-score: 1846.9  bits: 352.2 E(32554): 1.5e-96
Smith-Waterman score: 3944; 89.1% identity (89.2% similar) in 696 aa overlap (75-770:19-639)

           50        60        70        80        90       100    
pF1KB3 MNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQ
                                     ::::::::::::::::::::::::::::::
CCDS46             MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQ
                           10        20        30        40        

          110       120       130       140       150       160    
pF1KB3 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
       50        60        70        80        90       100        

          170       180       190       200       210       220    
pF1KB3 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
      110       120       130       140       150       160        

          230       240       250       260       270       280    
pF1KB3 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
      170       180       190       200       210       220        

          290       300       310       320       330       340    
pF1KB3 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
       ::::                                                        
CCDS46 EVVR--------------------------------------------------------
      230                                                          

          350       360       370       380       390       400    
pF1KB3 MSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
                          .::::::::::::::::::::::::::::::::::::::::
CCDS46 -------------------VPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
                               240       250       260       270   

          410       420       430       440       450       460    
pF1KB3 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
           280       290       300       310       320       330   

          470       480       490       500       510       520    
pF1KB3 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
           340       350       360       370       380       390   

          530       540       550       560       570       580    
pF1KB3 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
           400       410       420       430       440       450   

          590       600       610       620       630       640    
pF1KB3 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
           460       470       480       490       500       510   

          650       660       670       680       690       700    
pF1KB3 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
           520       530       540       550       560       570   

          710       720       730       740       750       760    
pF1KB3 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
           580       590       600       610       620       630   

          770
pF1KB3 FEQMQN
       ::::::
CCDS46 FEQMQN
             

>>CCDS56211.1 APP gene_id:351|Hs108|chr21                 (660 aa)
 initn: 2650 init1: 2650 opt: 2653  Z-score: 1846.7  bits: 352.2 E(32554): 1.5e-96
Smith-Waterman score: 4234; 89.7% identity (89.8% similar) in 735 aa overlap (36-770:1-660)

          10        20        30        40        50        60     
pF1KB3 ALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDT
                                     ::::::::::::::::::::::::::::::
CCDS56                               MFCGRLNMHMNVQNGKWDSDPSGTKTCIDT
                                             10        20        30

          70        80        90       100       110       120     
pF1KB3 KEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSD
               40        50        60        70        80        90

         130       140       150       160       170       180     
pF1KB3 ALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV
              100       110       120       130       140       150

         190       200       210       220       230       240     
pF1KB3 CCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 CCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDD
              160       170       180       190       200       210

         250       260       270       280       290       300     
pF1KB3 EDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMIS
       :::::::::::::::::::::::::::::::::::::::::::                 
CCDS56 EDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR-----------------
              220       230       240       250                    

         310       320       330       340       350       360     
pF1KB3 RWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLP
                                                                 .:
CCDS56 ----------------------------------------------------------VP
                                                                   

         370       380       390       400       410       420     
pF1KB3 TTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 TTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPK
         260       270       280       290       300       310     

         430       440       450       460       470       480     
pF1KB3 ADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPP
         320       330       340       350       360       370     

         490       500       510       520       530       540     
pF1KB3 RPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 RPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSL
         380       390       400       410       420       430     

         550       560       570       580       590       600     
pF1KB3 SLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 SLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVE
         440       450       460       470       480       490     

         610       620       630       640       650       660     
pF1KB3 LLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 LLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEE
         500       510       520       530       540       550     

         670       680       690       700       710       720     
pF1KB3 ISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKK
         560       570       580       590       600       610     

         730       740       750       760       770
pF1KB3 KQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       :::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
         620       630       640       650       660

>>CCDS13577.1 APP gene_id:351|Hs108|chr21                 (695 aa)
 initn: 2650 init1: 2650 opt: 2653  Z-score: 1846.4  bits: 352.3 E(32554): 1.6e-96
Smith-Waterman score: 4456; 90.1% identity (90.3% similar) in 770 aa overlap (1-770:1-695)

               10        20        30        40        50        60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
       ::::::::::::::::::::::::::::::::::::::::::::::::            
CCDS13 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR------------
              250       260       270       280                    

              310       320       330       340       350       360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
                                                                   
CCDS13 ------------------------------------------------------------
                                                                   

              370       380       390       400       410       420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
          .::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 ---VPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
         290       300       310       320       330       340     

              430       440       450       460       470       480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
         350       360       370       380       390       400     

              490       500       510       520       530       540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
         410       420       430       440       450       460     

              550       560       570       580       590       600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
         470       480       490       500       510       520     

              610       620       630       640       650       660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
         530       540       550       560       570       580     

              670       680       690       700       710       720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
         590       600       610       620       630       640     

              730       740       750       760       770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
         650       660       670       680       690     

>>CCDS8486.1 APLP2 gene_id:334|Hs108|chr11                (763 aa)
 initn: 2195 init1: 925 opt: 1295  Z-score: 908.9  bits: 178.9 E(32554): 2.6e-44
Smith-Waterman score: 2497; 50.5% identity (74.1% similar) in 798 aa overlap (5-769:15-762)

                         10        20                30        40  
pF1KB3           MLPGLALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLN
                     : ::::.. :: :: .        .:::    .::::::::::.::
CCDS84 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
               10        20        30        40        50        60

             50        60        70        80        90       100  
pF1KB3 MHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGR
       ::.:.:.:::. ::.:::.:..::: .::::::.:::::::::.:::: :.:.:::.: .
CCDS84 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
               70        80        90       100       110       120

            110       120       130       140       150       160  
pF1KB3 KQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKS
       ::::..  :: :..:::::::::.::::.::.:.:.:::.:::.: :::::.::.:  ..
CCDS84 KQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQG
                130       140       150       160       170        

            170       180       190       200       210       220  
pF1KB3 TNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSE
        .:..::::::::.:.:.:.:.:::: ..   .:.. . :::. .      . :: :  .
CCDS84 MTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYK
      180       190       200       210       220       230        

            230       240       250       260             270      
pF1KB3 DKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEE------ATERTTSIATTT
       ..    :. :. .:.  .:  ::::.:.:.:: :. .  :.         :  :  ..  
CCDS84 SEFPTEADLEDFTEAAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDG
       240       250         260       270       280       290     

        280       290       300       310       320       330      
pF1KB3 TTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEY
       : . . . . :. :::..: ::::::.. :::::...:::. :.:::::::::::..:.:
CCDS84 TMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDY
         300       310       320       330       340       350     

        340       350       360       370       380       390      
pF1KB3 CMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKE
       ::::: . .          :    :. :::      . :: :.:: .:.::::.::::::
CCDS84 CMAVCKAMI----------P----PTPLPT------NDVDVYFETSADDNEHARFQKAKE
         360                     370             380       390     

        400       410       420       430       440       450      
pF1KB3 RLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVET
       .:: .::.::..: .:::::: ::::::::.....:::::  :..::.:::.:.::::::
CCDS84 QLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVET
         400       410       420       430       440       450     

        460       470       480       490       500       510      
pF1KB3 HMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVR
       :.::::::::::::.:::::..:::. ::::..... :..:::::.::: ::..:..:: 
CCDS84 HLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVL
         460       470       480       490       500       510     

        520       530       540       550       560       570      
pF1KB3 MVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDV
        :::.::::..:::::::.:: :: ::::::::.:: ::.:::.:.:::::...      
CCDS84 AVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQR------
         520       530       540       550       560               

        580       590       600       610       620       630      
pF1KB3 LANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE
        :.:          : .  :..:: . :.   :..: : ... :.: :     ::  :::
CCDS84 -ADM----------DQFTASISETPVDVR---VSSEES-EEIPPFHPF--HPFPALPENE
      570                 580          590        600         610  

         640       650       660        670       680       690    
pF1KB3 -VEPVDARPAADRGLTTRPGSGLTNIKTEEI-SEVKMDAEFRHDSGYEVHHQKLVFFAED
        ..:   .:    . . .  .:: . . . : :. :.: ..  :   .:  ....: :: 
CCDS84 DTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDV--KEMIFNAER
            620       630       640       650       660         670

                           700       710       720       730       
pF1KB3 VGS-----------------NKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVE
       ::.                 ...:.:::.: .:.:::::::.::::.:.:: .: ::.::
CCDS84 VGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVE
              680       690       700       710       720       730

       740       750       760       770
pF1KB3 VDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
       ::  .:::::::.:::..::::::::..:::: 
CCDS84 VDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
              740       750       760   

>>CCDS44773.1 APLP2 gene_id:334|Hs108|chr11               (751 aa)
 initn: 2195 init1: 925 opt: 985  Z-score: 695.1  bits: 139.3 E(32554): 2.1e-32
Smith-Waterman score: 2498; 50.9% identity (75.1% similar) in 784 aa overlap (5-769:15-750)

                         10        20                30        40  
pF1KB3           MLPGLALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLN
                     : ::::.. :: :: .        .:::    .::::::::::.::
CCDS44 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
               10        20        30        40        50        60

             50        60        70        80        90       100  
pF1KB3 MHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGR
       ::.:.:.:::. ::.:::.:..::: .::::::.:::::::::.:::: :.:.:::.: .
CCDS44 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
               70        80        90       100       110       120

            110       120       130       140       150       160  
pF1KB3 KQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKS
       ::::..  :: :..:::::::::.::::.::.:.:.:::.:::.: :::::.::.:  ..
CCDS44 KQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQG
                130       140       150       160       170        

            170       180       190       200       210       220  
pF1KB3 TNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSE
        .:..::::::::.:.:.:.:.:::: ..   .:.. . :::. .      . :: :  .
CCDS44 MTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYK
      180       190       200       210       220       230        

            230       240       250       260             270      
pF1KB3 DKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEE------ATERTTSIATTT
       ..    :. :. .:.  .:  ::::.:.:.:: :. .  :.         :  :  ..  
CCDS44 SEFPTEADLEDFTEAAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDG
       240       250         260       270       280       290     

        280       290       300       310       320       330      
pF1KB3 TTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEY
       : . . . . :. :::..: ::::::.. :::::...:::. :.:::::::::::..:.:
CCDS44 TMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDY
         300       310       320       330       340       350     

        340       350       360       370       380       390      
pF1KB3 CMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKE
       ::::: . .          :    :. :::      . :: :.:: .:.::::.::::::
CCDS44 CMAVCKAMI----------P----PTPLPT------NDVDVYFETSADDNEHARFQKAKE
         360                     370             380       390     

        400       410       420       430       440       450      
pF1KB3 RLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVET
       .:: .::.::..: .:::::: ::::::::.....:::::  :..::.:::.:.::::::
CCDS44 QLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVET
         400       410       420       430       440       450     

        460       470       480       490       500       510      
pF1KB3 HMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVR
       :.::::::::::::.:::::..:::. ::::..... :..:::::.::: ::..:..:: 
CCDS44 HLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVL
         460       470       480       490       500       510     

        520       530       540       550       560       570      
pF1KB3 MVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDV
        :::.::::..:::::::.:: :: ::::::::.:: ::.:::.:.:::::...      
CCDS44 AVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQR------
         520       530       540       550       560               

        580       590       600       610       620       630      
pF1KB3 LANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE
        :.:          : .  :..:: . :.   :..: : ... :.: :     ::  :::
CCDS44 -ADM----------DQFTASISETPVDVR---VSSEES-EEIPPFHPF--HPFPALPENE
      570                 580          590        600         610  

        640           650       660       670        680       690 
pF1KB3 VEPVDARPA----ADRGLTTRPGSGLTNIKTEEISEVK-MDAEFRHDSGYEVHHQKLVFF
          :  . .    :.. . .  ..   :.  .:  .:: :  . .. .: : .....  .
CCDS44 GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPL
            620       630       640       650       660       670  

             700       710       720       730       740       750 
pF1KB3 AEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSK
        :: . ...:.:::.: .:.:::::::.::::.:.:: .: ::.::::  .:::::::.:
CCDS44 REDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNK
            680       690       700       710       720       730  

             760       770
pF1KB3 MQQNGYENPTYKFFEQMQN
       ::..::::::::..:::: 
CCDS44 MQNHGYENPTYKYLEQMQI
            740       750 




770 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 12:55:03 2016 done: Thu Nov  3 12:55:04 2016
 Total Scan time:  3.800 Total Display time:  0.230

Function used was FASTA [36.3.4 Apr, 2011]
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