Result of FASTA (omim) for
pF1KB3281
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3281, 787 aa
1>>>pF1KB3281 787 - 787 aa - 787 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5600+/-0.000485; mu= 9.9675+/- 0.030
mean_var=148.6897+/-30.628, 0's: 0 Z-trim(113.1): 88 B-trim: 511 in 3/52
Lambda= 0.105180
statistics sampled from 22271 (22359) to 22271 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.262), width: 16
Scan time: 9.960
The best scores are: opt bits E(85289)
NP_036580 (OMIM: 245590,604260) signal transducer ( 787) 5262 811.3 0
NP_003143 (OMIM: 601511) signal transducer and act ( 794) 4851 748.9 1.9e-215
NP_001275647 (OMIM: 601511) signal transducer and ( 794) 4851 748.9 1.9e-215
XP_016880466 (OMIM: 245590,604260) PREDICTED: sign ( 693) 4622 714.2 4.8e-205
XP_005257681 (OMIM: 601511) PREDICTED: signal tran ( 761) 4344 672.0 2.6e-192
NP_001275648 (OMIM: 601511) signal transducer and ( 764) 4080 631.9 3e-180
XP_005257683 (OMIM: 245590,604260) PREDICTED: sign ( 497) 3207 499.3 1.6e-140
NP_001275649 (OMIM: 601511) signal transducer and ( 763) 2857 446.4 2.2e-124
NP_003144 (OMIM: 601512) signal transducer and act ( 847) 1456 233.8 2.4e-60
XP_006719638 (OMIM: 601512) PREDICTED: signal tran ( 847) 1456 233.8 2.4e-60
NP_001171550 (OMIM: 601512) signal transducer and ( 847) 1456 233.8 2.4e-60
NP_001171549 (OMIM: 601512) signal transducer and ( 847) 1456 233.8 2.4e-60
NP_001171552 (OMIM: 601512) signal transducer and ( 737) 1451 233.0 3.6e-60
NP_001171551 (OMIM: 601512) signal transducer and ( 737) 1451 233.0 3.6e-60
XP_011537005 (OMIM: 601512) PREDICTED: signal tran ( 865) 968 159.8 4.7e-38
XP_011537008 (OMIM: 601512) PREDICTED: signal tran ( 865) 968 159.8 4.7e-38
XP_011537006 (OMIM: 601512) PREDICTED: signal tran ( 865) 968 159.8 4.7e-38
XP_011537007 (OMIM: 601512) PREDICTED: signal tran ( 865) 968 159.8 4.7e-38
XP_011537009 (OMIM: 601512) PREDICTED: signal tran ( 865) 968 159.8 4.7e-38
XP_011537011 (OMIM: 601512) PREDICTED: signal tran ( 755) 963 159.0 7.1e-38
XP_011537010 (OMIM: 601512) PREDICTED: signal tran ( 755) 963 159.0 7.1e-38
NP_644805 (OMIM: 102582,147060,615952) signal tran ( 770) 916 151.8 1e-35
XP_005257674 (OMIM: 102582,147060,615952) PREDICTE ( 770) 916 151.8 1e-35
XP_011523447 (OMIM: 102582,147060,615952) PREDICTE ( 770) 916 151.8 1e-35
XP_016880461 (OMIM: 102582,147060,615952) PREDICTE ( 722) 908 150.6 2.2e-35
XP_011523448 (OMIM: 102582,147060,615952) PREDICTE ( 722) 908 150.6 2.2e-35
NP_998827 (OMIM: 102582,147060,615952) signal tran ( 722) 908 150.6 2.2e-35
XP_016880463 (OMIM: 102582,147060,615952) PREDICTE ( 721) 907 150.4 2.5e-35
XP_016880465 (OMIM: 102582,147060,615952) PREDICTE ( 721) 907 150.4 2.5e-35
XP_016880462 (OMIM: 102582,147060,615952) PREDICTE ( 721) 907 150.4 2.5e-35
XP_005257673 (OMIM: 102582,147060,615952) PREDICTE ( 769) 907 150.5 2.6e-35
XP_016880464 (OMIM: 102582,147060,615952) PREDICTE ( 769) 907 150.5 2.6e-35
NP_003141 (OMIM: 102582,147060,615952) signal tran ( 769) 907 150.5 2.6e-35
NP_009330 (OMIM: 600555,613796,614162,614892) sign ( 750) 828 138.5 1e-31
XP_006712781 (OMIM: 600555,613796,614162,614892) P ( 750) 828 138.5 1e-31
XP_016860272 (OMIM: 600555,613796,614162,614892) P ( 752) 828 138.5 1e-31
NP_644671 (OMIM: 600555,613796,614162,614892) sign ( 712) 817 136.8 3.2e-31
XP_011510007 (OMIM: 600558,612253) PREDICTED: sign ( 748) 775 130.4 2.7e-29
NP_003142 (OMIM: 600558,612253) signal transducer ( 748) 775 130.4 2.7e-29
NP_001230764 (OMIM: 600558,612253) signal transduc ( 748) 775 130.4 2.7e-29
XP_006712782 (OMIM: 600558,612253) PREDICTED: sign ( 748) 775 130.4 2.7e-29
XP_011536999 (OMIM: 600556,616636) PREDICTED: sign ( 859) 614 106.0 6.9e-22
XP_011537000 (OMIM: 600556,616636) PREDICTED: sign ( 855) 613 105.9 7.7e-22
NP_938146 (OMIM: 600556,616636) signal transducer ( 847) 606 104.8 1.6e-21
NP_005410 (OMIM: 600556,616636) signal transducer ( 851) 583 101.3 1.8e-20
XP_011537002 (OMIM: 600556,616636) PREDICTED: sign ( 615) 518 91.4 1.3e-17
XP_016875393 (OMIM: 600556,616636) PREDICTED: sign ( 607) 496 88.0 1.3e-16
XP_011537001 (OMIM: 600556,616636) PREDICTED: sign ( 592) 469 83.9 2.2e-15
XP_016860273 (OMIM: 600558,612253) PREDICTED: sign ( 500) 297 57.8 1.4e-07
>>NP_036580 (OMIM: 245590,604260) signal transducer and (787 aa)
initn: 5262 init1: 5262 opt: 5262 Z-score: 4326.2 bits: 811.3 E(85289): 0
Smith-Waterman score: 5262; 99.9% identity (100.0% similar) in 787 aa overlap (1-787:1-787)
10 20 30 40 50 60
pF1KB3 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 LKRIKRSDRRGAKSVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ
730 740 750 760 770 780
pF1KB3 WIPHAQS
:::::::
NP_036 WIPHAQS
>>NP_003143 (OMIM: 601511) signal transducer and activat (794 aa)
initn: 4858 init1: 4344 opt: 4851 Z-score: 3989.1 bits: 748.9 E(85289): 1.9e-215
Smith-Waterman score: 4851; 93.7% identity (97.0% similar) in 779 aa overlap (1-779:1-774)
10 20 30 40 50 60
pF1KB3 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
:: :::::::::.::.:::.::::::::::::::.:::::: ::..::::::. .::::
NP_003 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
:::::::::::::::::::::::::::::::::::.::::::.:::::::::::::::::
NP_003 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
::::: ::::: :.::::::::::::::::::::::::::::::::::::::::::::::
NP_003 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::. ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::. ::::::::::::::::::::::::::::
NP_003 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 LKRIKRSDRRGAKSVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
::::::.:::::.::::::::.:::::::::.:::::::::::::::::::::::.::::
NP_003 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK
::::::::::::::::::::::::: :::::::::::::::::: :::::::::::::::
NP_003 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL
::::::::::::::::::::::::::::::::::: :: .::: ::::::::::::::::
NP_003 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG
:::.::::::::::::::.::::::: ::::::::::::::::::::::::::::
NP_003 GDLSYLIYVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVNASADAGG
670 680 690 700 710
730 740 750 760 770 780
pF1KB3 GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ
.::::::::::::::::: ::::::::: ::: ::.:::..::::::.::::: :::::
NP_003 SSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSL
720 730 740 750 760 770
pF1KB3 WIPHAQS
NP_003 DSRLSPPAGLFTSARGSLS
780 790
>>NP_001275647 (OMIM: 601511) signal transducer and acti (794 aa)
initn: 4858 init1: 4344 opt: 4851 Z-score: 3989.1 bits: 748.9 E(85289): 1.9e-215
Smith-Waterman score: 4851; 93.7% identity (97.0% similar) in 779 aa overlap (1-779:1-774)
10 20 30 40 50 60
pF1KB3 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
:: :::::::::.::.:::.::::::::::::::.:::::: ::..::::::. .::::
NP_001 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
:::::::::::::::::::::::::::::::::::.::::::.:::::::::::::::::
NP_001 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
::::: ::::: :.::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::. ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::. ::::::::::::::::::::::::::::
NP_001 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 LKRIKRSDRRGAKSVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
::::::.:::::.::::::::.:::::::::.:::::::::::::::::::::::.::::
NP_001 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK
::::::::::::::::::::::::: :::::::::::::::::: :::::::::::::::
NP_001 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL
::::::::::::::::::::::::::::::::::: :: .::: ::::::::::::::::
NP_001 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG
:::.::::::::::::::.::::::: ::::::::::::::::::::::::::::
NP_001 GDLSYLIYVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVNASADAGG
670 680 690 700 710
730 740 750 760 770 780
pF1KB3 GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ
.::::::::::::::::: ::::::::: ::: ::.:::..::::::.::::: :::::
NP_001 SSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSL
720 730 740 750 760 770
pF1KB3 WIPHAQS
NP_001 DSRLSPPAGLFTSARGSLS
780 790
>>XP_016880466 (OMIM: 245590,604260) PREDICTED: signal t (693 aa)
initn: 4622 init1: 4622 opt: 4622 Z-score: 3802.2 bits: 714.2 E(85289): 4.8e-205
Smith-Waterman score: 4622; 99.9% identity (100.0% similar) in 692 aa overlap (96-787:2-693)
70 80 90 100 110 120
pF1KB3 QELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANN
::::::::::::::::::::::::::::::
XP_016 MNTYDRCPMELVRCIRHILYNEQRLVREANN
10 20 30
130 140 150 160 170 180
pF1KB3 GSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQ
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB3 FGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQT
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB3 IILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPI
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB3 PGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMN
220 230 240 250 260 270
370 380 390 400 410 420
pF1KB3 PPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIK
280 290 300 310 320 330
430 440 450 460 470 480
pF1KB3 RSDRRGAKSVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWD
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWD
340 350 360 370 380 390
490 500 510 520 530 540
pF1KB3 NAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHL
400 410 420 430 440 450
550 560 570 580 590 600
pF1KB3 EDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHD
460 470 480 490 500 510
610 620 630 640 650 660
pF1KB3 LLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNY
520 530 540 550 560 570
670 680 690 700 710 720
pF1KB3 LIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGGGSATY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGGGSATY
580 590 600 610 620 630
730 740 750 760 770 780
pF1KB3 MDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHA
640 650 660 670 680 690
pF1KB3 QS
::
XP_016 QS
>>XP_005257681 (OMIM: 601511) PREDICTED: signal transduc (761 aa)
initn: 4344 init1: 4344 opt: 4344 Z-score: 3573.6 bits: 672.0 E(85289): 2.6e-192
Smith-Waterman score: 4344; 95.0% identity (98.1% similar) in 686 aa overlap (1-686:1-686)
10 20 30 40 50 60
pF1KB3 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
:: :::::::::.::.:::.::::::::::::::.:::::: ::..::::::. .::::
XP_005 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
:::::::::::::::::::::::::::::::::::.::::::.:::::::::::::::::
XP_005 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
::::: ::::: :.::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::. ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::. ::::::::::::::::::::::::::::
XP_005 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 LKRIKRSDRRGAKSVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
::::::.:::::.::::::::.:::::::::.:::::::::::::::::::::::.::::
XP_005 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK
::::::::::::::::::::::::: :::::::::::::::::: :::::::::::::::
XP_005 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL
::::::::::::::::::::::::::::::::::: :: .::: ::::::::::::::::
XP_005 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG
:::.::::::::::::::.:::::::
XP_005 GDLSYLIYVFPDRPKDEVFSKYYTPVLALTMYSIRMENSTWMRPWMWPGTWRNSYADQWT
670 680 690 700 710 720
>>NP_001275648 (OMIM: 601511) signal transducer and acti (764 aa)
initn: 4648 init1: 3573 opt: 4080 Z-score: 3357.1 bits: 631.9 E(85289): 3e-180
Smith-Waterman score: 4588; 90.2% identity (93.3% similar) in 779 aa overlap (1-779:1-744)
10 20 30 40 50 60
pF1KB3 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
:: :::::::::.::.:::.::::::::::::::.:::::: ::..::::::. .::::
NP_001 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
::::::::::::::::::::::::::::::::::: :
NP_001 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQ-----C-------------------
70 80 90
130 140 150 160 170 180
pF1KB3 REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
::::: :.::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------SSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB3 RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::. ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::. ::::::::::::::::::::::::::::
NP_001 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB3 LKRIKRSDRRGAKSVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
::::::.:::::.::::::::.:::::::::.:::::::::::::::::::::::.::::
NP_001 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB3 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB3 SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK
::::::::::::::::::::::::: :::::::::::::::::: :::::::::::::::
NP_001 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
520 530 540 550 560 570
610 620 630 640 650 660
pF1KB3 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL
::::::::::::::::::::::::::::::::::: :: .::: ::::::::::::::::
NP_001 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
580 590 600 610 620 630
670 680 690 700 710 720
pF1KB3 GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG
:::.::::::::::::::.::::::: ::::::::::::::::::::::::::::
NP_001 GDLSYLIYVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVNASADAGG
640 650 660 670 680
730 740 750 760 770 780
pF1KB3 GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ
.::::::::::::::::: ::::::::: ::: ::.:::..::::::.::::: :::::
NP_001 SSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSL
690 700 710 720 730 740
pF1KB3 WIPHAQS
NP_001 DSRLSPPAGLFTSARGSLS
750 760
>>XP_005257683 (OMIM: 245590,604260) PREDICTED: signal t (497 aa)
initn: 3207 init1: 3207 opt: 3207 Z-score: 2643.8 bits: 499.3 E(85289): 1.6e-140
Smith-Waterman score: 3207; 99.8% identity (100.0% similar) in 491 aa overlap (1-491:1-491)
10 20 30 40 50 60
pF1KB3 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 LKRIKRSDRRGAKSVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
:::::::::::
XP_005 TVLWDNAFAEPNIGFDC
490
>>NP_001275649 (OMIM: 601511) signal transducer and acti (763 aa)
initn: 4649 init1: 2857 opt: 2857 Z-score: 2354.1 bits: 446.4 E(85289): 2.2e-124
Smith-Waterman score: 4584; 89.9% identity (93.1% similar) in 779 aa overlap (1-779:1-743)
10 20 30 40 50 60
pF1KB3 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
:: :::::::::.::.:::.::::::::::::::.:::::: ::..::::::. .::::
NP_001 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
:::::::::::::::::::::::::::::::::::.::::::.:::::::::::::::::
NP_001 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
::::: ::::: :.::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::. ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::. ::::::::::::::::::::::::::::
NP_001 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 LKRIKRSDRRGAKSVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
::::::.:::::.::::::::.:::::::::.::::::::
NP_001 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVK--------------------
430 440 450 460
490 500 510 520 530 540
pF1KB3 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -----------GRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
470 480 490 500
550 560 570 580 590 600
pF1KB3 SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK
::::::::::::::::::::::::: :::::::::::::::::: :::::::::::::::
NP_001 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
510 520 530 540 550 560
610 620 630 640 650 660
pF1KB3 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL
::::::::::::::::::::::::::::::::::: :: .::: ::::::::::::::::
NP_001 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
570 580 590 600 610 620
670 680 690 700 710 720
pF1KB3 GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG
:::.::::::::::::::.::::::: ::::::::::::::::::::::::::::
NP_001 GDLSYLIYVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVNASADAGG
630 640 650 660 670 680
730 740 750 760 770 780
pF1KB3 GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ
.::::::::::::::::: ::::::::: ::: ::.:::..::::::.::::: :::::
NP_001 SSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSL
690 700 710 720 730 740
pF1KB3 WIPHAQS
NP_001 DSRLSPPAGLFTSARGSLS
750 760
>>NP_003144 (OMIM: 601512) signal transducer and activat (847 aa)
initn: 1446 init1: 948 opt: 1456 Z-score: 1204.5 bits: 233.8 E(85289): 2.4e-60
Smith-Waterman score: 1576; 38.9% identity (64.9% similar) in 792 aa overlap (1-771:1-720)
10 20 30 40 50
pF1KB3 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDS-VDLDNPQENIKATQ
:..: .... : ..: :: . :: ..:: :..:.::: :. : : :. :.
NP_003 MSLWGLVSKMPPE---KVQRLYVD-FPQHLRHLLGDWLESQPWEFLVGSDAFCCNL-ASA
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 LLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRL
:: ::.:: .. .: :: . .:. : .: :.. :.: :..:: .:.:: .:..
NP_003 LLSDTVQHLQASVGEQ-GEGSTILQ----HIST-LESIYQRDPLKLVATFRQILQGEKKA
60 70 80 90 100
120 130 140 150 160 170
pF1KB3 VREANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQES
: : :..: . . ..::: .. .
NP_003 VMEQ------------------------FRHLPMPFHWKQEELK------------FKTG
110 120 130
180 190 200 210 220 230
pF1KB3 LR-IQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQ
:: .: . : . : : . . . . ::::.. .. :. .. :: :.:
NP_003 LRRLQHRVGEIHLL----REALQKGAEAGQVSLHSLIETPANGTGPSEA-LAMLLQETTG
140 150 160 170 180
240 250 260 270 280 290
pF1KB3 LLRKQQTIILDDELIQ-WKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAE
:. ....: . :: :::.:::::::.: : :: :: ::.:..: : .:.. :
NP_003 ELEAAKALVL--KRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAA-
190 200 210 220 230 240
300 310 320 330 340 350
pF1KB3 HLCQQLPIPGPVE-EMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLV
: .: . : ... . ... .:::: :..:::::::::::::: : ::.:.
NP_003 --------GGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLL
250 260 270 280 290
360 370 380 390 400 410
pF1KB3 GGK-LNVHMNPPQVKATIISEQQAK--SLLKNENTRNDYSGEILNNCCVMEYHQATGTLS
: . :.. .:: :.: ...:.::. :. .. .. . .:::.:: .: . :
NP_003 GLRFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCS
300 310 320 330 340 350
420 430 440 450 460 470
pF1KB3 AHFRNMSLKRIKRSDRRGAKSVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGS
: :.:. ::.::: .:.:..:::::: ..:: ..:..: ..: .:...::::.::::::.
NP_003 ALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGN
360 370 380 390 400 410
480 490 500 510 520 530
pF1KB3 QDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFL
::::: ::.::::::.: ::::.: ..: : ..::.::.:: ::: .:::: :...::
NP_003 QDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFL
420 430 440 450 460 470
540 550 560 570 580 590
pF1KB3 AQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGA
:::.::..: .: .. ::::::::.: : ::..:::::::::... :. :. .:.:
NP_003 AQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRL
480 490 500 510 520 530
600 610 620 630 640 650
pF1KB3 ILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQER--MFWNLMPFTTRDF
:.::..:: . .::.:.:::::::::::::::::::: . .:. .. :..::...:.
NP_003 IIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDL
540 550 560 570 580 590
660 670 680 690 700
pF1KB3 SIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVV---
:::::.::. :: : ..: .::::.. ..: : .: ::: ::..:
NP_003 SIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKP----EQMGKDGRGYVPATIKMTVERD
600 610 620 630 640 650
710 720 730 740 750
pF1KB3 -----PEF----VNASADAGGGSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDL
::. . : : : . . :.. .: . :: .:: . :. .: ..
NP_003 QPLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQ----VYPPHSHSIPPYQG-LSP
660 670 680 690 700
760 770 780
pF1KB3 EDTMDVARRVEELLGRPMDSQWIPHAQS
:....: .:
NP_003 EESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMV
710 720 730 740 750 760
>>XP_006719638 (OMIM: 601512) PREDICTED: signal transduc (847 aa)
initn: 1446 init1: 948 opt: 1456 Z-score: 1204.5 bits: 233.8 E(85289): 2.4e-60
Smith-Waterman score: 1576; 38.9% identity (64.9% similar) in 792 aa overlap (1-771:1-720)
10 20 30 40 50
pF1KB3 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDS-VDLDNPQENIKATQ
:..: .... : ..: :: . :: ..:: :..:.::: :. : : :. :.
XP_006 MSLWGLVSKMPPE---KVQRLYVD-FPQHLRHLLGDWLESQPWEFLVGSDAFCCNL-ASA
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 LLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRL
:: ::.:: .. .: :: . .:. : .: :.. :.: :..:: .:.:: .:..
XP_006 LLSDTVQHLQASVGEQ-GEGSTILQ----HIST-LESIYQRDPLKLVATFRQILQGEKKA
60 70 80 90 100
120 130 140 150 160 170
pF1KB3 VREANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQES
: : :..: . . ..::: .. .
XP_006 VMEQ------------------------FRHLPMPFHWKQEELK------------FKTG
110 120 130
180 190 200 210 220 230
pF1KB3 LR-IQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQ
:: .: . : . : : . . . . ::::.. .. :. .. :: :.:
XP_006 LRRLQHRVGEIHLL----REALQKGAEAGQVSLHSLIETPANGTGPSEA-LAMLLQETTG
140 150 160 170 180
240 250 260 270 280 290
pF1KB3 LLRKQQTIILDDELIQ-WKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAE
:. ....: . :: :::.:::::::.: : :: :: ::.:..: : .:.. :
XP_006 ELEAAKALVL--KRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAA-
190 200 210 220 230 240
300 310 320 330 340 350
pF1KB3 HLCQQLPIPGPVE-EMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLV
: .: . : ... . ... .:::: :..:::::::::::::: : ::.:.
XP_006 --------GGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLL
250 260 270 280 290
360 370 380 390 400 410
pF1KB3 GGK-LNVHMNPPQVKATIISEQQAK--SLLKNENTRNDYSGEILNNCCVMEYHQATGTLS
: . :.. .:: :.: ...:.::. :. .. .. . .:::.:: .: . :
XP_006 GLRFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCS
300 310 320 330 340 350
420 430 440 450 460 470
pF1KB3 AHFRNMSLKRIKRSDRRGAKSVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGS
: :.:. ::.::: .:.:..:::::: ..:: ..:..: ..: .:...::::.::::::.
XP_006 ALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGN
360 370 380 390 400 410
480 490 500 510 520 530
pF1KB3 QDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFL
::::: ::.::::::.: ::::.: ..: : ..::.::.:: ::: .:::: :...::
XP_006 QDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFL
420 430 440 450 460 470
540 550 560 570 580 590
pF1KB3 AQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGA
:::.::..: .: .. ::::::::.: : ::..:::::::::... :. :. .:.:
XP_006 AQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRL
480 490 500 510 520 530
600 610 620 630 640 650
pF1KB3 ILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQER--MFWNLMPFTTRDF
:.::..:: . .::.:.:::::::::::::::::::: . .:. .. :..::...:.
XP_006 IIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDL
540 550 560 570 580 590
660 670 680 690 700
pF1KB3 SIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVV---
:::::.::. :: : ..: .::::.. ..: : .: ::: ::..:
XP_006 SIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKP----EQMGKDGRGYVPATIKMTVERD
600 610 620 630 640 650
710 720 730 740 750
pF1KB3 -----PEF----VNASADAGGGSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDL
::. . : : : . . :.. .: . :: .:: . :. .: ..
XP_006 QPLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQ----VYPPHSHSIPPYQG-LSP
660 670 680 690 700
760 770 780
pF1KB3 EDTMDVARRVEELLGRPMDSQWIPHAQS
:....: .:
XP_006 EESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMV
710 720 730 740 750 760
787 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 12:42:49 2016 done: Thu Nov 3 12:42:51 2016
Total Scan time: 9.960 Total Display time: 0.220
Function used was FASTA [36.3.4 Apr, 2011]